Leukemia Research

Leukemia Research

Research into leukemia at Penn State Cancer Institute is conducted by the leukemia and lymphoma team. See current clinical trials and members of that team here.

Clinical Trials

Blood and Bone Marrow Sampling for Tissue Banking
A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens including Rare Pediatric Tumors.
Protocol for the Enrollment on the Official COG Registry, the Childhood Cancer Research Network (CCRN)
Umbrella Long-term Follow-up Protocol
A Multi-Center, Open-Label, Study to Evaluate the Safety and Efficacy of Ublituximab (TG-1101) in Combination with TGR-1202 for Patients Previously Enrolled in Protocol UTX-TGR-304
A Phase 3, Randomized, Adaptive Study Comparing the Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients Undergoing Hematopoietic Stem Cell Transplant
Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome
A Phase III Study for Patients With Newly Diagnosed Acute Promyelocytic Leukemia (APL) Using Arsenic Trioxide and All-trans Retinoic Acid
A Phase 1/2 Open-label Rollover Study for Subjects Who Have Participated in an Astellas Sponsored ASP2215 Trial
A Phase II Study of Pevonedistat (MLN4924, TAK924) and Azacitidine as Maintenance Therapy after Allogeneic Stem Cell Transplantation for Non-Remission Acute Myelogenous Leukemia
A Groupwide Pilot Study to Test the Tolerability and Biologic Activity of the Addition of Azacitidine (IND# 133688, NSC# 102816) to Chemotherapy in Infants with Acute Lymphoblastic Leukemia (ALL) and KMT2A (MLL) Gene Rearrangement
Biologic Studies of Experimental Anti-Cancer Therapeutics in Human Leukemia Cells
A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum
Describe the Safety of Early Discharge After AML Induction Chemotherapy
Determinants of Survival in Allogenic Marrow and Stem Cell Transplant at Hershey Medical Center (HMC)
T-Cell Exhaustion in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia
Evaluation of Toxicity in Older Adult Acute Lymphoblastic Leukemia (ALL) Patients Using Pegaspargase (Cap vs No Cap) vs L-Asparaginase
A Phase III Randomized Trial Investigating Bortezomib (NSC# 681239) on a Modified Augmented BFM (ABFM) Backbone in Newly Diagnosed T- Lymphoblastic Leukemia (T-ALL) and T- Lymphoblastic Lymphoma (T-LLy)
A Phase III Randomized, Open Label, Multi-Center Study of the Safety and Efficacy of Apixaban for Thromboembolism Prevention versus No Systemic Anticoagulant Prophylaxis during Induction Chemotherapy in Children with Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) or Lymphoma (T or B cell) Treated with Pegylated Asparaginase
Phase I Study of Carfilzomib in Combination with Cyclophosphamide and Etoposide for Children with Relapsed and Refractory Solid Tumors and Leukemias
The Project: Every Child Protocol: A Registry, Eligibility Screening, Biology and Outcome Study
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.

Disease Team Members

First Name Last Name Title Role
David Claxton, MD David Claxton MD View Profile
W. Christopher Ehmann, MD W. Christopher Ehmann MD View Profile
Raymond Hohl, MD, PhD Raymond Hohl MD, PhD View Profile
Muhammad Khawaja, MD Muhammad Khawaja MD View Profile
Heath Mackley, MD, FACRO Heath Mackley MD, FACRO View Profile
Shin Mineishi, MD Shin Mineishi MD View Profile
Seema Naik, MD Seema Naik MD View Profile
Witold Rybka, MD, FRCPC Witold Rybka MD, FRCPC View Profile
Henry Wagner Jr., MD Henry Wagner Jr. MD View Profile
Hong Zheng, MD, PhD Hong Zheng MD, PhD View Profile
Research into leukemia at Penn State Cancer Institute is conducted by the leukemia and lymphoma team. See current clinical trials and members of that team here.
Blood and Bone Marrow Sampling for Tissue Banking
A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens including Rare Pediatric Tumors.
Protocol for the Enrollment on the Official COG Registry, the Childhood Cancer Research Network (CCRN)
Umbrella Long-term Follow-up Protocol
A Multi-Center, Open-Label, Study to Evaluate the Safety and Efficacy of Ublituximab (TG-1101) in Combination with TGR-1202 for Patients Previously Enrolled in Protocol UTX-TGR-304
A Phase 3, Randomized, Adaptive Study Comparing the Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients Undergoing Hematopoietic Stem Cell Transplant
Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome
A Phase III Study for Patients With Newly Diagnosed Acute Promyelocytic Leukemia (APL) Using Arsenic Trioxide and All-trans Retinoic Acid
A Phase 1/2 Open-label Rollover Study for Subjects Who Have Participated in an Astellas Sponsored ASP2215 Trial
A Phase II Study of Pevonedistat (MLN4924, TAK924) and Azacitidine as Maintenance Therapy after Allogeneic Stem Cell Transplantation for Non-Remission Acute Myelogenous Leukemia
A Groupwide Pilot Study to Test the Tolerability and Biologic Activity of the Addition of Azacitidine (IND# 133688, NSC# 102816) to Chemotherapy in Infants with Acute Lymphoblastic Leukemia (ALL) and KMT2A (MLL) Gene Rearrangement
Biologic Studies of Experimental Anti-Cancer Therapeutics in Human Leukemia Cells
A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND# 73789, NSC# 606869) in the Very High Risk Stratum
Describe the Safety of Early Discharge After AML Induction Chemotherapy
Determinants of Survival in Allogenic Marrow and Stem Cell Transplant at Hershey Medical Center (HMC)
T-Cell Exhaustion in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia
Evaluation of Toxicity in Older Adult Acute Lymphoblastic Leukemia (ALL) Patients Using Pegaspargase (Cap vs No Cap) vs L-Asparaginase
A Phase III Randomized Trial Investigating Bortezomib (NSC# 681239) on a Modified Augmented BFM (ABFM) Backbone in Newly Diagnosed T- Lymphoblastic Leukemia (T-ALL) and T- Lymphoblastic Lymphoma (T-LLy)
A Phase III Randomized, Open Label, Multi-Center Study of the Safety and Efficacy of Apixaban for Thromboembolism Prevention versus No Systemic Anticoagulant Prophylaxis during Induction Chemotherapy in Children with Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) or Lymphoma (T or B cell) Treated with Pegylated Asparaginase
Phase I Study of Carfilzomib in Combination with Cyclophosphamide and Etoposide for Children with Relapsed and Refractory Solid Tumors and Leukemias
The Project: Every Child Protocol: A Registry, Eligibility Screening, Biology and Outcome Study
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.
First Name Last Name Title Role
David Claxton, MD David Claxton MD View Profile
W. Christopher Ehmann, MD W. Christopher Ehmann MD View Profile
Raymond Hohl, MD, PhD Raymond Hohl MD, PhD View Profile
Muhammad Khawaja, MD Muhammad Khawaja MD View Profile
Heath Mackley, MD, FACRO Heath Mackley MD, FACRO View Profile
Shin Mineishi, MD Shin Mineishi MD View Profile
Seema Naik, MD Seema Naik MD View Profile
Witold Rybka, MD, FRCPC Witold Rybka MD, FRCPC View Profile
Henry Wagner Jr., MD Henry Wagner Jr. MD View Profile
Hong Zheng, MD, PhD Hong Zheng MD, PhD View Profile

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)