Researcher Profile

Researcher Profile

Raymond Hohl, MD, PhD

Raymond Hohl, MD, PhD

University Professorship in Oncology, Department of Medicine
Professor, Department of Pharmacology
Scientific Program:Next-Generation Therapies
Disease Teams:
Bone Marrow Transplantation
Leukemia and Lymphoma
rjh35@psu.edu
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Research Interests

  • Neoplasms
  • Terpenes
  • Therapeutics
  • Lovastatin
  • Proteins
  • Prenylation
  • Diphosphonates
  • Leukemia
  • farnesyl pyrophosphate
  • geranylgeranyl pyrophosphate
  • Pharmacokinetics
  • Protein Prenylation

Clinical Trials

Blood and Bone Marrow Collection from Patients with Hematological Malignancies for Study of Anti-Tumor Immunity
Clofarabine followed by Fludarabine, Busulfan, Total-Body Irradiation and Hematopoietic Stem Cell Transplant with Post-Transplant Cyclophosphamide for Non-remission Acute Myeloid Leukemia
A Phase Ib/II Study of Venetoclax (ABT-199) in Combination with Liposomal Vincristine in Patients with Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia
An Open-Label, Randomized, Multicenter, Phase Ib/II Trial Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) In Combination with Polatuzumab Vedotin in Patients with B-Cell Non-Hodgkin Lymphoma
Assessment of Allogeneic Hematopoietic Cell Transplantation in Medicare Beneficiaries with Multiple Myeloma: A Study to Develop Evidence of Effectiveness for the Centers for Medicare and Medicaid Services (CMS)
Managed Access Program (MAP) to provide access to CTL019, for acute lymphoblastic leukemia (ALL) or large B-cell lymphoma patients with out of specification leukapheresis product and/or manufactured tisagenlecleucel out of specification for commercial release
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation

Recent Publications

2020

Zheng, H, Mineishi, S, Claxton, D, Zhu, J, Zhao, C, Jia, B, Ehmann, WC, Rybka, WB, Naik, S, Songdej, N, Drabick, JJ & Hohl, RJ 2021, 'A phase I clinical trial of avelumab in combination with decitabine as first line treatment of unfit patients with acute myeloid leukemia', American Journal of Hematology, vol. 96, no. 2, pp. E46-E50. https://doi.org/10.1002/ajh.26043
Bluethmann, SM, Wang, M, Wasserman, E, Chen, C, Zaorsky, NG, Hohl, RJ & McDonald, AC 2020, 'Prostate cancer in Pennsylvania: The role of older age at diagnosis, aggressiveness, and environmental risk factors on treatment and mortality using data from the Pennsylvania Cancer Registry', Cancer medicine, vol. 9, no. 10, pp. 3623-3633. https://doi.org/10.1002/cam4.3003
McDonald, AC, Wasserman, E, Lengerich, EJ, Raman, JD, Geyer, NR, Hohl, RJ & Wang, M 2020, 'Prostate cancer incidence and aggressiveness in appalachia versus non-appalachia populations in Pennsylvania by urban-rural regions, 2004–2014', Cancer Epidemiology Biomarkers and Prevention, vol. 29, no. 7, pp. 1365-1373. https://doi.org/10.1158/1055-9965.EPI-19-1232
Wang, M, Wasserman, E, Geyer, N, Carroll, RM, Zhao, S, Zhang, L, Hohl, R, Lengerich, EJ & McDonald, AC 2020, 'Spatial patterns in prostate Cancer-specific mortality in Pennsylvania using Pennsylvania Cancer registry data, 2004-2014', BMC Cancer, vol. 20, no. 1, 394. https://doi.org/10.1186/s12885-020-06902-5

2019

Huang, X, Sterling, NW, Du, G, Sun, D, Stetter, C, Kong, L, Zhu, Y, Neighbors, J, Lewis, MM, Chen, H, Hohl, RJ & Mailman, RB 2019, 'Brain cholesterol metabolism and Parkinson's disease', Movement Disorders, vol. 34, no. 3, pp. 386-395. https://doi.org/10.1002/mds.27609
Weissenrieder, JS, Neighbors, JD, Mailman, RB & Hohl, RJ 2019, 'Cancer and the dopamine D2 receptor: A pharmacological perspective', Journal of Pharmacology and Experimental Therapeutics, vol. 370, no. 1, pp. 111-126. https://doi.org/10.1124/jpet.119.256818
Jia, B, Zhao, C, Rakszawski, KL, Claxton, DF, Christopher Ehmann, W, Rybka, WB, Mineishi, S, Wang, M, Shike, H, Bayerl, MG, Sivik, JM, Schell, TD, Drabick, JJ, Hohl, RJ & Zheng, H 2019, 'Eomes+T-betlow CD8+ T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia', Cancer Research, vol. 79, no. 7, pp. 1635-1645. https://doi.org/10.1158/0008-5472.CAN-18-3107
Allen, BG, Bodeker, KL, Smith, MC, Monga, V, Sandhu, S, Hohl, R, Carlisle, T, Brown, H, Hollenbeck, N, Vollstedt, S, Greenlee, JD, Howard, MA, Mapuskar, KA, Seyedin, SN, Caster, JM, Jones, KA, Cullen, JJ, Berg, D, Wagner, BA, Buettner, GR, TenNapel, MJ, Smith, BJ, Spitz, DR & Buatti, JM 2019, 'First-in-human phase I clinical trial of pharmacologic ascorbate combined with radiation and temozolomide for newly diagnosed glioblastoma', Clinical Cancer Research, vol. 25, no. 22, pp. 6590-6597. https://doi.org/10.1158/1078-0432.CCR-19-0594
Larson-Casey, JL, Vaid, M, Gu, L, He, C, Cai, GQ, Ding, Q, Davis, D, Berryhill, TF, Wilson, LS, Barnes, S, Neighbors, JD, Hohl, RJ, Zimmerman, KA, Yoder, BK, Longhini, ALF, Hanumanthu, VS, Surolia, R, Antony, VB & Brent Carter, A 2019, 'Increased flux through the mevalonate pathway mediates fibrotic repair without injury', Journal of Clinical Investigation, vol. 129, no. 11, pp. 4962-4978. https://doi.org/10.1172/JCI127959
Zhao, C, Jia, B, Wang, M, Schell, TD, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Naik, S, Songdej, N, Sivik, JM, Hohl, RJ, Zeng, H & Zheng, H 2020, 'Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML', British Journal of Haematology, vol. 188, no. 5, pp. 674-684. https://doi.org/10.1111/bjh.16228
Weissenrieder, JS, Reed, JL, Green, MV, Moldovan, GL, Koubek, EJ, Neighbors, JD & Hohl, RJ 2020, 'The Dopamine D2 Receptor Contributes to the Spheroid Formation Behavior of U87 Glioblastoma Cells', Pharmacology, vol. 105, no. 1-2, pp. 19-27. https://doi.org/10.1159/000502562

2018

Jia, B, Wang, L, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Rizvi, S, Shike, H, Bayerl, M, Schell, TD, Hohl, RJ & Zheng, H 2018, 'Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients', Blood Cancer Journal, vol. 8, no. 3, 34. https://doi.org/10.1038/s41408-018-0069-4
Weissenrieder, JS, Reilly, JE, Neighbors, JD & Hohl, RJ 2019, 'Inhibiting geranylgeranyl diphosphate synthesis reduces nuclear androgen receptor signaling and neuroendocrine differentiation in prostate cancer cell models', Prostate, vol. 79, no. 1, pp. 21-30. https://doi.org/10.1002/pros.23707
Kokolus, KM, Haley, JS, Koubek, EJ, Gowda, R, Dinavahi, SS, Sharma, A, Claxton, DF, Helm, KF, Drabick, JJ, Robertson, GP, Neighbors, JD, Hohl, RJ & Schell, TD 2019, 'Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity', OncoImmunology, vol. 8, no. 2, e1539614. https://doi.org/10.1080/2162402X.2018.1539614
Koubek, EJ, Weissenrieder, JS, Neighbors, JD & Hohl, RJ 2018, 'Schweinfurthins: Lipid Modulators with Promising Anticancer Activity', Lipids, vol. 53, no. 8, pp. 767-784. https://doi.org/10.1002/lipd.12088
Wang, L, Jia, B, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Naik, S, Khawaja, MR, Sivik, J, Han, J, Hohl, RJ & Zheng, H 2018, 'VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML', OncoImmunology, vol. 7, no. 9, e1469594. https://doi.org/10.1080/2162402X.2018.1469594

2017

Zhu, L, Kong, Y, Zhang, J, Claxton, DF, Ehmann, WC, Rybka, WB, Palmisiano, ND, Wang, M, Jia, B, Bayerl, M, Schell, TD, Hohl, RJ, Zeng, H & Zheng, H 2017, 'Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia', Journal of Hematology and Oncology, vol. 10, no. 1, 124. https://doi.org/10.1186/s13045-017-0486-z
Lee, JSH, Blumenthal, GM, Hohl, RJ & Huang, SM 2017, 'Cancer Therapy: Shooting for the Moon', Clinical pharmacology and therapeutics, vol. 101, no. 5, pp. 552-558. https://doi.org/10.1002/cpt.655
Schoenfeld, JD, Sibenaller, ZA, Mapuskar, KA, Wagner, BA, Cramer-Morales, KL, Furqan, M, Sandhu, S, Carlisle, TL, Smith, MC, Abu Hejleh, T, Berg, DJ, Zhang, J, Keech, J, Parekh, KR, Bhatia, S, Monga, V, Bodeker, KL, Ahmann, L, Vollstedt, S, Brown, H, Shanahan Kauffman, EP, Schall, ME, Hohl, RJ, Clamon, GH, Greenlee, JD, Howard, MA, Shultz, MK, Smith, BJ, Riley, DP, Domann, FE, Cullen, JJ, Buettner, GR, Buatti, JM, Spitz, DR & Allen, BG 2017, 'O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate', Cancer Cell, vol. 31, no. 4, pp. 487-500.e8. https://doi.org/10.1016/j.ccell.2017.02.018
Teye, EK, Sido, A, Xin, P, Finnberg, NK, Gokare, P, Kawasawa, YI, Salzberg, AC, Shimko, S, Bayerl, M, Ehmann, WC, Claxton, DF, Rybka, WB, Drabick, JJ, Wang, HG, Abraham, T, El-Deiry, WS, Brodsky, RA, J.Hohl, R & Pu, JJ 2017, 'PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features', Oncotarget, vol. 8, no. 18, pp. 29887-29905. https://doi.org/10.18632/oncotarget.15136
Reilly, JE, Neighbors, JD & Hohl, RJ 2017, 'Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis', Cancer Biology and Therapy, vol. 18, no. 11, pp. 872-882. https://doi.org/10.1080/15384047.2016.1219817

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)