Researcher Profile

Researcher Profile

Shin Mineishi, MD

Shin Mineishi, MD

Professor, Department of Medicine
Director of Bone Marrow Transplantation, Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Bone Marrow Transplantation
Immunotherapy
Leukemia and Lymphoma
szm328@psu.edu

Research Interests

  • Transplants
  • Hematopoietic Stem Cell Transplantation
  • Therapeutics
  • Stem Cell Transplantation
  • Graft vs Host Disease
  • T-Lymphocytes
  • Tissue Donors
  • Stem Cells
  • Allogeneic Cells
  • Recurrence
  • Busulfan
  • Leukemia

Recent Publications

2022

Jamy, O, Arora, S, Meredith, R, Salzman, D, Di Stasi, A, Minagawa, K, Mineishi, S & Saad, A 2022, 'Phase II study of myeloablative allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia in adults using fludarabine and total body irradiation 12 Gy', Bone Marrow Transplantation. https://doi.org/10.1038/s41409-022-01757-9
Zhao, C, Bartock, M, Jia, B, Shah, N, Claxton, DF, Wirk, B, Rakszawski, KL, Nickolich, MS, Naik, SG, Rybka, WB, Ehmann, WCC, Hohl, RJ, Valentin, J, Bernas-Peterson, M, Gerber, EM, Zimmerman, M, Mierski, JA, Mineishi, S & Zheng, H 2022, 'Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant', Journal of Hematology and Oncology, vol. 15, no. 1, 64. https://doi.org/10.1186/s13045-022-01287-3

2021

Jia, B, Zhao, C, Bayerl, M, Shike, H, Claxton, DF, Ehmann, WC, Mineishi, S, Schell, TD, Zheng, P, Zhang, Y, Shultz, LD, Prabhu, KS, Paulson, RF & Zheng, H 2022, 'A novel clinically relevant graft-versus-leukemia model in humanized mice', Journal of Leukocyte Biology, vol. 111, no. 2, pp. 427-437. https://doi.org/10.1002/JLB.5AB0820-542RR
Mochizuki, K, Kobayashi, S, Takahashi, N, Sugimoto, K, Sano, H, Ohara, Y, Mineishi, S, Zhang, Y & Kikuta, A 2021, 'Alloantigen-activated (AAA) CD4+ T cells reinvigorate host endogenous T cell immunity to eliminate pre-established tumors in mice', Journal of Experimental and Clinical Cancer Research, vol. 40, no. 1, 314. https://doi.org/10.1186/s13046-021-02102-6
Tian, Y, Meng, L, Wang, Y, Li, B, Yu, H, Zhou, Y, Bui, T, Abraham, C, Li, A, Zhang, Y, Wang, J, Zhao, C, Mineishi, S, Gallucci, S, Porter, D, Hexner, E, Zheng, H, Zhang, Y, Hu, S & Zhang, Y 2021, 'Graft-versus-host disease depletes plasmacytoid dendritic cell progenitors to impair tolerance induction', Journal of Clinical Investigation, vol. 131, no. 1, e136774. https://doi.org/10.1172/JCI136774
Shah, N, Rakszawski, K, Nickolich, M, Ehmann, C, Wirk, B, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Mackey, G, Greiner, R, Brown, V, Claxton, D, Mineishi, S & Minagawa, K 2021, 'Improved outcome in AML relapse after allogeneic transplant with high-intensity chemotherapy followed by 2nd allogeneic stem cell transplant or donor lymphocyte infusion', Annals of Hematology, vol. 100, no. 10, pp. 2585-2592. https://doi.org/10.1007/s00277-021-04616-7
Jamy, O, Innis-Shelton, R, Bal, S, Paluri, R, Salzman, D, Di Stasi, A, Costa, L, Meredith, R, Lamb, L, Minagawa, K, Mineishi, S & Saad, A 2021, 'Phase II clinical trial of one dose of post-transplant cyclophosphamide for graft versus host disease prevention following myeloablative, peripheral blood stem cell, matched-unrelated donor transplantation', American Journal of Hematology, vol. 96, no. 10, pp. E396-E398. https://doi.org/10.1002/ajh.26296
Gvozdjan, K, Casey, H, Mowery, C, Kumer, L, Fisher, C, Tyler, J, Bayerl, MG, Malysz, J, Naik, S, Rybka, W, Ehmann, C, Claxton, D, Mineishi, S, Baker, M, Hong, Z & Shike, H 2021, 'Unexpected Short-Tandem-Repeat Patterns in Post-Transplant Chimerism Testing: Investigation of 3 Cases with Help from Forensic Science', Laboratory Medicine, vol. 51, no. 6, pp. 635-641. https://doi.org/10.1093/LABMED/LMAA022

2020

Zheng, H, Mineishi, S, Claxton, D, Zhu, J, Zhao, C, Jia, B, Ehmann, WC, Rybka, WB, Naik, S, Songdej, N, Drabick, JJ & Hohl, RJ 2021, 'A phase I clinical trial of avelumab in combination with decitabine as first line treatment of unfit patients with acute myeloid leukemia', American Journal of Hematology, vol. 96, no. 2, pp. E46-E50. https://doi.org/10.1002/ajh.26043

2019

McCune, JS, Wang, T, Bo-Subait, K, Aljurf, M, Beitinjaneh, A, Bubalo, J, Cahn, JY, Cerny, J, Chhabra, S, Cumpston, A, Dupuis, LL, Lazarus, HM, Marks, DI, Maziarz, RT, Norkin, M, Prestidge, T, Mineishi, S, Krem, MM, Pasquini, M & Martin, PJ 2019, 'Association of Antiepileptic Medications with Outcomes after Allogeneic Hematopoietic Cell Transplantation with Busulfan/Cyclophosphamide Conditioning', Biology of Blood and Marrow Transplantation, vol. 25, no. 7, pp. 1424-1431. https://doi.org/10.1016/j.bbmt.2019.03.001
Sabloff, M, Chhabra, S, Wang, T, Fretham, C, Kekre, N, Abraham, A, Adekola, K, Auletta, JJ, Barker, C, Beitinjaneh, AM, Bredeson, C, Cahn, JY, Diaz, MA, Freytes, C, Gale, RP, Ganguly, S, Gergis, U, Guinan, E, Hamilton, BK, Hashmi, S, Hematti, P, Hildebrandt, G, Holmberg, L, Hong, S, Lazarus, HM, Martino, R, Muffly, L, Nishihori, T, Perales, MA, Yared, J, Mineishi, S, Stadtmauer, EA, Pasquini, MC & Loren, AW 2019, 'Comparison of High Doses of Total Body Irradiation in Myeloablative Conditioning before Hematopoietic Cell Transplantation', Biology of Blood and Marrow Transplantation, vol. 25, no. 12, pp. 2398-2407. https://doi.org/10.1016/j.bbmt.2019.08.012
Yu, H, Tian, Y, Wang, Y, Mineishi, S & Zhang, Y 2019, 'Dendritic Cell Regulation of Graft Vs.-Host Disease: Immunostimulation and Tolerance Immunostimulation', Frontiers in immunology, vol. 10, no. FEB, 93. https://doi.org/10.3389/fimmu.2019.00093
Jia, B, Zhao, C, Rakszawski, KL, Claxton, DF, Christopher Ehmann, W, Rybka, WB, Mineishi, S, Wang, M, Shike, H, Bayerl, MG, Sivik, JM, Schell, TD, Drabick, JJ, Hohl, RJ & Zheng, H 2019, 'Eomes+T-betlow CD8+ T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia', Cancer Research, vol. 79, no. 7, pp. 1635-1645. https://doi.org/10.1158/0008-5472.CAN-18-3107
Zhao, C, Jia, B, Wang, M, Schell, TD, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Naik, S, Songdej, N, Sivik, JM, Hohl, RJ, Zeng, H & Zheng, H 2020, 'Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML', British Journal of Haematology, vol. 188, no. 5, pp. 674-684. https://doi.org/10.1111/bjh.16228
Thakar, MS, Broglie, L, Logan, B, Artz, A, Bunin, N, Burroughs, LM, Fretham, C, Jacobsohn, DA, Loren, AW, Kurtzberg, J, Martinez, CA, Mineishi, S, Nelson, AS, Woolfrey, A, Pasquini, MC & Sorror, ML 2019, 'The Hematopoietic Cell Transplant Comorbidity Index predicts survival after allogeneic transplant for nonmalignant diseases', Blood, vol. 133, no. 7, pp. 754-762. https://doi.org/10.1182/blood-2018-09-876284

2018

Jia, B, Wang, L, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Rizvi, S, Shike, H, Bayerl, M, Schell, TD, Hohl, RJ & Zheng, H 2018, 'Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients', Blood Cancer Journal, vol. 8, no. 3, 34. https://doi.org/10.1038/s41408-018-0069-4
Rakszawski, K, Miki, K, Claxton, D, Wagner Jr., H, Shike, H, Mineishi, S & Naik, S 2018, 'Clofarabine followed by haploidentical stem cell transplant using fludarabine, busulfan, and total-body irradiation with post-transplant cyclophosphamide in non-remission AML', International journal of hematology, vol. 108, no. 3, pp. 348-350. https://doi.org/10.1007/s12185-018-2431-5
Harris, AC, Boelens, JJ, Ahn, KW, Fei, M, Abraham, A, Artz, A, Dvorak, C, Frangoul, H, Freytes, C, Gale, RP, Hong, S, Lazarus, HM, Loren, A, Mineishi, S, Nishihori, T, O’Brien, T, Williams, K, Pasquini, MC & Levine, JE 2018, 'Comparison of pediatric allogeneic transplant outcomes using myeloablative busulfan with cyclophosphamide or fludarabine', Blood Advances, vol. 2, no. 11, pp. 1198-1206. https://doi.org/10.1182/bloodadvances.2018016956
Brunstein, CG, Pasquini, MC, Kim, S, Fei, M, Adekola, K, Ahmed, I, Aljurf, M, Agrawal, V, Auletta, JJ, Battiwalla, M, Bejanyan, N, Bubalo, J, Cerny, J, Chee, L, Ciurea, SO, Freytes, C, Gadalla, SM, Gale, RP, Ganguly, S, Hashmi, SK, Hematti, P, Hildebrandt, G, Holmberg, LA, Lahoud, OB, Landau, H, Lazarus, HM, de Lima, M, Mathews, V, Maziarz, R, Nishihori, T, Norkin, M, Olsson, R, Reshef, R, Rotz, S, Savani, B, Schouten, HC, Seo, S, Wirk, BM, Yared, J, Mineishi, S, Rogosheske, J & Perales, MA 2019, 'Effect of Conditioning Regimen Dose Reduction in Obese Patients Undergoing Autologous Hematopoietic Cell Transplantation', Biology of Blood and Marrow Transplantation, vol. 25, no. 3, pp. 480-487. https://doi.org/10.1016/j.bbmt.2018.11.005
Saad, A, Taneja, A, Di Stasi, A, Sarmad, R, Kukkamalla, R, Costa, L, Salzman, D, Innis-Shelton, R, Chewning, JH, Meredith, RF, Hauptfeld, V, Langford, S, Plessala, KA, Bhatia, R, Lamb, LS & Mineishi, S 2018, 'Impact of high-dose steroid premedication on the outcome of myeloablative T-cell replete haploidentical peripheral blood stem cell transplant', Bone Marrow Transplantation, vol. 53, no. 10, pp. 1345-1348. https://doi.org/10.1038/s41409-018-0185-6
Sullivan, KM, Goldmuntz, EA, Keyes-Elstein, L, McSweeney, PA, Pinckney, A, Welch, B, Mayes, MD, Nash, RA, Crofford, LJ, Eggleston, B, Castina, S, Griffith, LM, Goldstein, JS, Wallace, D, Craciunescu, O, Khanna, D, Folz, RJ, Goldin, J, Clair, EW, Seibold, JR, Phillips, K, Mineishi, S, Simms, RW, Ballen, K, Wener, MH, Georges, GE, Heimfeld, S, Hosing, C, Forman, S, Kafaja, S, Silver, RM, Griffing, L, Storek, J, LeClercq, S, Brasington, R, Csuka, ME, Bredeson, C, Keever-Taylor, C, Domsic, RT, Kahaleh, MB, Medsger, T & Furst, DE 2018, 'Myeloablative autologous stem-cell transplantation for severe scleroderma', New England Journal of Medicine, vol. 378, no. 1, pp. 35-47. https://doi.org/10.1056/NEJMoa1703327
Wang, L, Jia, B, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Naik, S, Khawaja, MR, Sivik, J, Han, J, Hohl, RJ & Zheng, H 2018, 'VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML', OncoImmunology, vol. 7, no. 9, e1469594. https://doi.org/10.1080/2162402X.2018.1469594

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)