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Researcher Profile

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Shin Mineishi, MD

Shin Mineishi, MD

Professor, Department of Medicine
Director of Bone Marrow Transplantation, Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Bone Marrow Transplantation Team
Cancer Institute, Immunotherapy Team
Cancer Institute, Leukemia and Lymphoma Team
SZM328@psu.edu

Research Interests

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  • Transplants
  • Hematopoietic Stem Cell Transplantation
  • Therapeutics
  • Stem Cell Transplantation
  • Graft vs Host Disease
  • T-Lymphocytes
  • Tissue Donors
  • Stem Cells
  • Allogeneic Cells
  • Recurrence
  • Busulfan
  • Leukemia
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Recent Publications

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2023

Potiaumpai, M, Schmitz, KH, Mineishi, S, Naik, S, Wirk, B, Rakszawski, K, Ehmann, WC, Claxton, D, Nickolich, M, Zemel, BS & Zheng, H 2023, 'IMPROVE-BMT: A protocol for a pilot randomised controlled trial of prehabilitation exercise for adult haematopoietic stem cell transplant recipients', BMJ open, vol. 13, no. 1, e066841. https://doi.org/10.1136/bmjopen-2022-066841

2022

Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2023, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology, vol. 102, no. 3, pp. 613-620. https://doi.org/10.1007/s00277-022-05077-2
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Pizzola, CJ, Cioccio, J, Rakszawski, KL, Nickolich, M, Ehmann, WC, Rybka, WB, Wirk, B, Naik, S, Zheng, H, Silar, B, Shike, H, Zhou, S, Mineishi, S, Minagawa, K & Claxton, DF 2022, 'Non-myeloablative allogeneic stem cell transplant with fludarabine and reduced dose cyclophosphamide in acute myeloid leukemia for older adults with comorbidities', Bone Marrow Transplantation, vol. 57, no. 11, pp. 1743-1745. https://doi.org/10.1038/s41409-022-01821-4
Jamy, O, Arora, S, Meredith, R, Salzman, D, Di Stasi, A, Minagawa, K, Mineishi, S & Saad, A 2022, 'Phase II study of myeloablative allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia in adults using fludarabine and total body irradiation 12 Gy', Bone Marrow Transplantation, vol. 57, no. 10, pp. 1597-1599. https://doi.org/10.1038/s41409-022-01757-9
Zhao, C, Bartock, M, Jia, B, Shah, N, Claxton, DF, Wirk, B, Rakszawski, KL, Nickolich, MS, Naik, SG, Rybka, WB, Ehmann, WCC, Hohl, RJ, Valentin, J, Bernas-Peterson, M, Gerber, EM, Zimmerman, M, Mierski, JA, Mineishi, S & Zheng, H 2022, 'Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant', Journal of Hematology and Oncology, vol. 15, no. 1, 64. https://doi.org/10.1186/s13045-022-01287-3

2021

Jia, B, Zhao, C, Bayerl, M, Shike, H, Claxton, DF, Ehmann, WC, Mineishi, S, Schell, TD, Zheng, P, Zhang, Y, Shultz, LD, Prabhu, KS, Paulson, RF & Zheng, H 2022, 'A novel clinically relevant graft-versus-leukemia model in humanized mice', Journal of Leukocyte Biology, vol. 111, no. 2, pp. 427-437. https://doi.org/10.1002/JLB.5AB0820-542RR
Mochizuki, K, Kobayashi, S, Takahashi, N, Sugimoto, K, Sano, H, Ohara, Y, Mineishi, S, Zhang, Y & Kikuta, A 2021, 'Alloantigen-activated (AAA) CD4+ T cells reinvigorate host endogenous T cell immunity to eliminate pre-established tumors in mice', Journal of Experimental and Clinical Cancer Research, vol. 40, no. 1, 314. https://doi.org/10.1186/s13046-021-02102-6
Tian, Y, Meng, L, Wang, Y, Li, B, Yu, H, Zhou, Y, Bui, T, Abraham, C, Li, A, Zhang, Y, Wang, J, Zhao, C, Mineishi, S, Gallucci, S, Porter, D, Hexner, E, Zheng, H, Zhang, Y, Hu, S & Zhang, Y 2021, 'Graft-versus-host disease depletes plasmacytoid dendritic cell progenitors to impair tolerance induction', Journal of Clinical Investigation, vol. 131, no. 1, e136774. https://doi.org/10.1172/JCI136774
Shah, N, Rakszawski, K, Nickolich, M, Ehmann, C, Wirk, B, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Mackey, G, Greiner, R, Brown, V, Claxton, D, Mineishi, S & Minagawa, K 2021, 'Improved outcome in AML relapse after allogeneic transplant with high-intensity chemotherapy followed by 2nd allogeneic stem cell transplant or donor lymphocyte infusion', Annals of Hematology, vol. 100, no. 10, pp. 2585-2592. https://doi.org/10.1007/s00277-021-04616-7
Jamy, O, Innis-Shelton, R, Bal, S, Paluri, R, Salzman, D, Di Stasi, A, Costa, L, Meredith, R, Lamb, L, Minagawa, K, Mineishi, S & Saad, A 2021, 'Phase II clinical trial of one dose of post-transplant cyclophosphamide for graft versus host disease prevention following myeloablative, peripheral blood stem cell, matched-unrelated donor transplantation', American Journal of Hematology, vol. 96, no. 10, pp. E396-E398. https://doi.org/10.1002/ajh.26296
Gvozdjan, K, Casey, H, Mowery, C, Kumer, L, Fisher, C, Tyler, J, Bayerl, MG, Malysz, J, Naik, S, Rybka, W, Ehmann, C, Claxton, D, Mineishi, S, Baker, M, Hong, Z & Shike, H 2021, 'Unexpected Short-Tandem-Repeat Patterns in Post-Transplant Chimerism Testing: Investigation of 3 Cases with Help from Forensic Science', Laboratory Medicine, vol. 51, no. 6, pp. 635-641. https://doi.org/10.1093/LABMED/LMAA022

2020

Zheng, H, Mineishi, S, Claxton, D, Zhu, J, Zhao, C, Jia, B, Ehmann, WC, Rybka, WB, Naik, S, Songdej, N, Drabick, JJ & Hohl, RJ 2021, 'A phase I clinical trial of avelumab in combination with decitabine as first line treatment of unfit patients with acute myeloid leukemia', American Journal of Hematology, vol. 96, no. 2, pp. E46-E50. https://doi.org/10.1002/ajh.26043

2019

McCune, JS, Wang, T, Bo-Subait, K, Aljurf, M, Beitinjaneh, A, Bubalo, J, Cahn, JY, Cerny, J, Chhabra, S, Cumpston, A, Dupuis, LL, Lazarus, HM, Marks, DI, Maziarz, RT, Norkin, M, Prestidge, T, Mineishi, S, Krem, MM, Pasquini, M & Martin, PJ 2019, 'Association of Antiepileptic Medications with Outcomes after Allogeneic Hematopoietic Cell Transplantation with Busulfan/Cyclophosphamide Conditioning', Biology of Blood and Marrow Transplantation, vol. 25, no. 7, pp. 1424-1431. https://doi.org/10.1016/j.bbmt.2019.03.001
Sabloff, M, Chhabra, S, Wang, T, Fretham, C, Kekre, N, Abraham, A, Adekola, K, Auletta, JJ, Barker, C, Beitinjaneh, AM, Bredeson, C, Cahn, JY, Diaz, MA, Freytes, C, Gale, RP, Ganguly, S, Gergis, U, Guinan, E, Hamilton, BK, Hashmi, S, Hematti, P, Hildebrandt, G, Holmberg, L, Hong, S, Lazarus, HM, Martino, R, Muffly, L, Nishihori, T, Perales, MA, Yared, J, Mineishi, S, Stadtmauer, EA, Pasquini, MC & Loren, AW 2019, 'Comparison of High Doses of Total Body Irradiation in Myeloablative Conditioning before Hematopoietic Cell Transplantation', Biology of Blood and Marrow Transplantation, vol. 25, no. 12, pp. 2398-2407. https://doi.org/10.1016/j.bbmt.2019.08.012
Yu, H, Tian, Y, Wang, Y, Mineishi, S & Zhang, Y 2019, 'Dendritic Cell Regulation of Graft Vs.-Host Disease: Immunostimulation and Tolerance Immunostimulation', Frontiers in immunology, vol. 10, no. FEB, 93. https://doi.org/10.3389/fimmu.2019.00093
Jia, B, Zhao, C, Rakszawski, KL, Claxton, DF, Christopher Ehmann, W, Rybka, WB, Mineishi, S, Wang, M, Shike, H, Bayerl, MG, Sivik, JM, Schell, TD, Drabick, JJ, Hohl, RJ & Zheng, H 2019, 'Eomes+T-betlow CD8+ T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia', Cancer Research, vol. 79, no. 7, pp. 1635-1645. https://doi.org/10.1158/0008-5472.CAN-18-3107
Zhao, C, Jia, B, Wang, M, Schell, TD, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Naik, S, Songdej, N, Sivik, JM, Hohl, RJ, Zeng, H & Zheng, H 2020, 'Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML', British Journal of Haematology, vol. 188, no. 5, pp. 674-684. https://doi.org/10.1111/bjh.16228
Thakar, MS, Broglie, L, Logan, B, Artz, A, Bunin, N, Burroughs, LM, Fretham, C, Jacobsohn, DA, Loren, AW, Kurtzberg, J, Martinez, CA, Mineishi, S, Nelson, AS, Woolfrey, A, Pasquini, MC & Sorror, ML 2019, 'The Hematopoietic Cell Transplant Comorbidity Index predicts survival after allogeneic transplant for nonmalignant diseases', Blood, vol. 133, no. 7, pp. 754-762. https://doi.org/10.1182/blood-2018-09-876284
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