Researcher Profile

Researcher Profile

Shin Mineishi, MD

Shin Mineishi, MD

Professor, Department of Medicine
Division of Hematology and Oncology
Scientific Program:Experimental Therapeutics
Disease Teams:
Bone Marrow Transplantation
Immunotherapy
Leukemia and Lymphoma
szm328@psu.edu

Research Interests

  • Transplants
  • Hematopoietic Stem Cell Transplantation
  • Stem Cell Transplantation
  • Therapeutics
  • Graft vs Host Disease
  • T-Lymphocytes
  • Tissue Donors
  • Stem Cells
  • Busulfan
  • Leukemia
  • Recurrence
  • Transplantation

Recent Publications

2019

McCune, JS, Wang, T, Bo-Subait, K, Aljurf, M, Beitinjaneh, A, Bubalo, J, Cahn, JY, Cerny, J, Chhabra, S, Cumpston, A, Dupuis, LL, Lazarus, HM, Marks, DI, Maziarz, RT, Norkin, M, Prestidge, T, Mineishi, S, Krem, MM, Pasquini, M & Martin, PJ 2019, 'Association of Antiepileptic Medications with Outcomes after Allogeneic Hematopoietic Cell Transplantation with Busulfan/Cyclophosphamide Conditioning', Biology of Blood and Marrow Transplantation, vol. 25, no. 7, pp. 1424-1431. https://doi.org/10.1016/j.bbmt.2019.03.001
Yu, H, Tian, Y, Wang, Y, Mineishi, S & Zhang, Y 2019, 'Dendritic Cell Regulation of Graft Vs.-Host Disease: Immunostimulation and Tolerance Immunostimulation', Frontiers in immunology, vol. 10, no. FEB, 93. https://doi.org/10.3389/fimmu.2019.00093
Jia, B, Zhao, C, Rakszawski, KL, Claxton, D, Ehmann, WC, Rybka, W, Mineishi, S, Wang, M, Shike, H, Bayerl, M, Sivik, JM, Schell, T, Drabick, J, Hohl, R & Zheng, H 2019, 'Eomes+T-betlow CD8+ T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia', Cancer Research, vol. 79, no. 7, pp. 1635-1645. https://doi.org/10.1158/0008-5472.CAN-18-3107
Thakar, MS, Broglie, L, Logan, B, Artz, A, Bunin, N, Burroughs, LM, Fretham, C, Jacobsohn, DA, Loren, AW, Kurtzberg, J, Martinez, CA, Mineishi, S, Nelson, AS, Woolfrey, A, Pasquini, MC & Sorror, ML 2019, 'The Hematopoietic Cell Transplant Comorbidity Index predicts survival after allogeneic transplant for nonmalignant diseases', Blood, vol. 133, no. 7, pp. 754-762. https://doi.org/10.1182/blood-2018-09-876284

2018

Jia, B, Wang, L, Claxton, D, Ehmann, WC, Rybka, W, Mineishi, S, Rizvi, S, Shike, H, Bayerl, M, Schell, T, Hohl, R & Zheng, H 2018, 'Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients', Blood Cancer Journal, vol. 8, no. 3, 34. https://doi.org/10.1038/s41408-018-0069-4
Rakszawski, K, Miki, K, Claxton, D, Wagner, H, Shike, H, Mineishi, S & Naik, S 2018, 'Clofarabine followed by haploidentical stem cell transplant using fludarabine, busulfan, and total-body irradiation with post-transplant cyclophosphamide in non-remission AML', International journal of hematology, vol. 108, no. 3, pp. 348-350. https://doi.org/10.1007/s12185-018-2431-5
Harris, AC, Boelens, JJ, Ahn, KW, Fei, M, Abraham, A, Artz, A, Dvorak, C, Frangoul, H, Freytes, C, Gale, RP, Hong, S, Lazarus, HM, Loren, A, Mineishi, S, Nishihori, T, O'Brien, T, Williams, K, Pasquini, MC & Levine, JE 2018, 'Comparison of pediatric allogeneic transplant outcomes using myeloablative busulfan with cyclophosphamide or fludarabine', Blood advances, vol. 2, no. 11, pp. 1198-1206. https://doi.org/10.1182/bloodadvances.2018016956
Brunstein, CG, Pasquini, MC, Kim, S, Fei, M, Adekola, K, Ahmed, I, Aljurf, M, Agrawal, V, Auletta, JJ, Battiwalla, M, Bejanyan, N, Bubalo, J, Cerny, J, Chee, L, Ciurea, SO, Freytes, C, Gadalla, SM, Gale, RP, Ganguly, S, Hashmi, SK, Hematti, P, Hildebrandt, G, Holmberg, LA, Lahoud, OB, Landau, H, Lazarus, HM, de Lima, M, Mathews, V, Maziarz, R, Nishihori, T, Norkin, M, Olsson, R, Reshef, R, Rotz, S, Savani, B, Schouten, HC, Seo, S, Wirk, B, Yared, J, Mineishi, S, Rogosheske, J & Perales, MA 2019, 'Effect of Conditioning Regimen Dose Reduction in Obese Patients Undergoing Autologous Hematopoietic Cell Transplantation', Biology of Blood and Marrow Transplantation, vol. 25, no. 3, pp. 480-487. https://doi.org/10.1016/j.bbmt.2018.11.005
Saad, A, Taneja, A, Di Stasi, A, Sarmad, R, Kukkamalla, R, Costa, L, Salzman, D, Innis-Shelton, R, Chewning, JH, Meredith, RF, Hauptfeld, V, Langford, S, Plessala, KA, Bhatia, R, Lamb, LS & Mineishi, S 2018, 'Impact of high-dose steroid premedication on the outcome of myeloablative T-cell replete haploidentical peripheral blood stem cell transplant', Bone Marrow Transplantation, vol. 53, no. 10, pp. 1345-1348. https://doi.org/10.1038/s41409-018-0185-6
Sullivan, KM, Goldmuntz, EA, Keyes-Elstein, L, McSweeney, PA, Pinckney, A, Welch, B, Mayes, MD, Nash, RA, Crofford, LJ, Eggleston, B, Castina, S, Griffith, LM, Goldstein, JS, Wallace, D, Craciunescu, O, Khanna, D, Folz, RJ, Goldin, J, Clair, EW, Seibold, JR, Phillips, K, Mineishi, S, Simms, RW, Ballen, K, Wener, MH, Georges, GE, Heimfeld, S, Hosing, C, Forman, S, Kafaja, S, Silver, RM, Griffing, L, Storek, J, LeClercq, S, Brasington, R, Csuka, ME, Bredeson, C, Keever-Taylor, C, Domsic, RT, Kahaleh, MB, Medsger, T & Furst, DE 2018, 'Myeloablative autologous stem-cell transplantation for severe scleroderma', New England Journal of Medicine, vol. 378, no. 1, pp. 35-47. https://doi.org/10.1056/NEJMoa1703327
Wang, L, Jia, B, Claxton, D, Ehmann, WC, Rybka, W, Mineishi, S, Naik, S, Khawaja, MR, Sivik, J, Han, J, Hohl, R & Zheng, H 2018, 'VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML' OncoImmunology, vol. 7, no. 9, e1469594. https://doi.org/10.1080/2162402X.2018.1469594

2017

Khalaf, AM, Hashim, MA, Alsharabati, M, Fallon, K, Cure, JK, Pappas, P, Mineishi, S & Saad, A 2017, 'Late-onset cerebral toxoplasmosis after allogeneic hematopoietic stem cell transplantation', American Journal of Case Reports, vol. 18, 899687, pp. 246-250. https://doi.org/10.12659/AJCR.899687
Haverkos, BM, Abbott, D, Hamadani, M, Armand, P, Flowers, ME, Merryman, R, Kamdar, M, Kanate, AS, Saad, A, Mehta, A, Ganguly, S, Fenske, TS, Hari, P, Lowsky, R, Andritsos, L, Jagasia, M, Bashey, A, Brown, S, Bachanova, V, Stephens, D, Mineishi, S, Nakamura, R, Chen, YB, Blazar, BR, Gutman, J & Devine, SM 2017, 'PD-1 blockade for relapsed lymphoma post-allogeneic hematopoietic cell transplant: High response rate but frequent GVHD', Blood, vol. 130, no. 2, pp. 221-228. https://doi.org/10.1182/blood-2017-01-761346

2016

Magenau, J, Westervelt, P, Khaled, S, McGuirk, J, Hari, P, Eapen, M, Becker, PS, Parkin, B, Braun, T, Logan, B, Wang, H, Jagasia, M, Rowley, SD, Kim, DDH, Schechter, T, Frey, N, Scott, B, Churay, T, Lieland, S, Forman, S & Mineishi, S 2017, 'A multicenter trial of myeloablative clofarabine and busulfan conditioning for relapsed or primary induction failure AML not in remission at the time of allogeneic hematopoietic stem cell transplantation', Bone Marrow Transplantation, vol. 52, no. 1, pp. 59-65. https://doi.org/10.1038/bmt.2016.188
Khan, M, Ubogu, E, Alsharabati, M, Salzman, D, Mineishi, S & Saad, A 2016, 'Acute myofascitis as a manifestation of chronic graft-versus-host disease', Muscle and Nerve, vol. 53, no. 2, pp. 327-329. https://doi.org/10.1002/mus.24937
Flowers, CR, Costa, LJ, Pasquini, MC, Le-Rademacher, J, Lill, M, Shore, TB, Vaughan, W, Craig, M, Freytes, CO, Shea, TC, Horwitz, ME, Fay, JW, Mineishi, S, Rondelli, D, Mason, J, Braunschweig, I, Ai, W, Yeh, RF, Rodriguez, TE, Flinn, I, Comeau, T, Yeager, AM, Pulsipher, MA, Bence-Bruckler, I, Laneuville, P, Bierman, P, Chen, AI, Kato, K, Wang, Y, Xu, C, Smith, AJ & Waller, EK 2016, 'Efficacy of Pharmacokinetics-Directed Busulfan, Cyclophosphamide, and Etoposide Conditioning and Autologous Stem Cell Transplantation for Lymphoma: Comparison of a Multicenter Phase II Study and CIBMTR Outcomes', Biology of Blood and Marrow Transplantation, vol. 22, no. 7, pp. 1197-1205. https://doi.org/10.1016/j.bbmt.2016.03.018
Minagawa, K, Jamil, MO, Al-Obaidi, M, Pereboeva, L, Salzman, D, Erba, HP, Lamb, LS, Bhatia, R, Mineishi, S & Di Stasi, A 2016, 'In vitro pre-clinical validation of suicide gene modified anti-CD33 redirected chimeric antigen receptor T-cells for acute myeloid leukemia', PloS one, vol. 11, no. 12, e0166891. https://doi.org/10.1371/journal.pone.0166891
Pasquini, MC, Le-Rademacher, J, Zhu, X, Artz, A, DiPersio, J, Fernandez, HF, Mineishi, S, Kamishohara, M, Mehta, J, Nakamura, Y, Ratanatharathorn, V, Sobecks, R, Burkart, J & Bredeson, C 2016, 'Intravenous Busulfan-Based Myeloablative Conditioning Regimens Prior to Hematopoietic Cell Transplantation for Hematologic Malignancies', Biology of Blood and Marrow Transplantation, vol. 22, no. 8, pp. 1424-1430. https://doi.org/10.1016/j.bbmt.2016.04.013
Richardson, PG, Riches, ML, Kernan, NA, Brochstein, JA, Mineishi, S, Termuhlen, AM, Arai, S, Grupp, SA, Guinan, EC, Martin, PL, Steinbach, G, Krishnan, A, Nemecek, ER, Giralt, S, Rodriguez, T, Duerst, R, Doyle, J, Antin, JH, Smith, A, Lehmann, L, Champlin, R, Gillio, A, Bajwa, R, D'Agostino, RB, Massaro, J, Warren, D, Miloslavsky, M, Hume, RL, Iacobelli, M, Nejadnik, B, Hannah, AL & Soiffer, RJ 2016, 'Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure', Blood, vol. 127, no. 13, pp. 1656-1665. https://doi.org/10.1182/blood-2015-10-676924
Al Malki, MM, Horowitz, M, Handgretinger, R, Leung, W, Roy, DC, Huang, XJ, Fuchs, E, Locatelli, F, Blaise, D, Mineishi, S, Martelli, M, Miller, J, June, C, Ai, HS, Luznik, L, Mavilio, D, Lugli, E, van den Brink, MRM, Champlin, RE & Ciurea, SO 2016, 'Proceedings from the Second Haploidentical Stem Cell Transplantation Symposium-Haplo2014, San Francisco, California, December 4, 2014', Biology of Blood and Marrow Transplantation, vol. 22, no. 4, pp. 594-604. https://doi.org/10.1016/j.bbmt.2016.01.001
Mochizuki, K, Meng, L, Mochizuki, I, Tong, Q, He, S, Liu, Y, Purushe, J, Fung, H, Zaidi, MR, Zhang, Y, Reshef, R, Blazar, BR, Yagita, H, Mineishi, S & Zhang, Y 2016, 'Programming of donor T cells using allogeneic δ-like ligand 4-positive dendritic cells to reduce GVHD in mice', Blood, vol. 127, no. 25, pp. 3270-3280. https://doi.org/10.1182/blood-2015-05-644476
Pawarode, A, Mineishi, S, Reddy, P, Braun, TM, Khaled, YA, Choi, SW, Magenau, JM, Harris, AC, Connelly, JA, Kitko, CL, Parkin, BL, Goldstein, SC, Yanik, GA, Levine, JE, Ferrara, JL & Couriel, DR 2016, 'Reducing Treatment-Related Mortality Did Not Improve Outcomes of Allogeneic Myeloablative Hematopoietic Cell Transplantation for High-Risk Multiple Myeloma: A University of Michigan Prospective Series', Biology of Blood and Marrow Transplantation, vol. 22, no. 1, pp. 54-60. https://doi.org/10.1016/j.bbmt.2015.07.021
Borate, UM, Mineishi, S & Costa, LJ 2016, 'Reply to a note on the magnitude of hazard ratios', Cancer, vol. 122, no. 8, pp. 1299-1300. https://doi.org/10.1002/cncr.29923
Aboul Nour, H, Patil, N, Chewning, JH, Di Stasi, A, Salzman, D, Innis-Shelton, R, Lamb, L, Mineishi, S & Saad, A 2017, 'Safety of repeated un-manipulated peripheral blood stem cell haploidentical transplant for graft failure', Bone Marrow Transplantation, vol. 52, no. 1, pp. 157-158. https://doi.org/10.1038/bmt.2016.208
Meng, L, Bai, Z, He, S, Mochizuki, K, Liu, Y, Purushe, J, Sun, H, Wang, J, Yagita, H, Mineishi, S, Fung, H, Yanik, GA, Caricchio, R, Fan, X, Crisalli, LM, Hexner, EO, Reshef, R, Zhang, Y & Zhang, Y 2016, 'The notch ligand DLL4 defines a capability of human dendritic cells in regulating Th1 and Th17 differentiation', Journal of Immunology, vol. 196, no. 3, pp. 1070-1080. https://doi.org/10.4049/jimmunol.1501310
Mineishi, S 2016, 'Update on stem cell transplantation for acute leukemias', [Rinsho ketsueki] The Japanese journal of clinical hematology, vol. 57, no. 10, pp. 2218-2223.

2015

Magenau, JM, Braun, T, Reddy, P, Parkin, B, Pawarode, A, Mineishi, S, Choi, S, Levine, J, Li, Y, Yanik, G, Kitko, C, Churay, T, Frame, D, Riwes, MM, Harris, A, Bixby, D, Couriel, DR & Goldstein, SC 2015, 'Allogeneic transplantation with myeloablative FluBu4 conditioning improves survival compared to reduced intensity FluBu2 conditioning for acute myeloid leukemia in remission', Annals of Hematology, vol. 94, no. 6, pp. 1033-1041. https://doi.org/10.1007/s00277-015-2349-4
Borate, UM, Mineishi, S & Costa, LJ 2015, 'Nonbiological factors affecting survival in younger patients with acute myeloid leukemia', Cancer, vol. 121, no. 21, pp. 3877-3884. https://doi.org/10.1002/cncr.29436
Innis-Shelton, RD, Davis, RS, Lamb, L & Mineishi, S 2015, 'Paradigm shifts in the management of poor-risk chronic lymphocytic leukemia', Leukemia and Lymphoma, vol. 56, no. 6, pp. 1626-1635. https://doi.org/10.3109/10428194.2014.974041
Minagawa, K, Zhou, X, Mineishi, S & Di Stasi, A 2015, 'Seatbelts in CAR therapy: How safe are CARS?', Pharmaceuticals, vol. 8, no. 2, pp. 230-249. https://doi.org/10.3390/ph8020230
Jamil, MO & Mineishi, S 2015, 'State-of-the-art acute and chronic GVHD treatment', International Journal of Hematology, vol. 101, no. 5, pp. 452-466. https://doi.org/10.1007/s12185-015-1785-1
Saad, A, Mineishi, S & Innis-Shelton, R 2015, 'Telomere length in hematopoietic stem cell transplantation for severe aplastic anemia is it ready for "prime time"?', JAMA - Journal of the American Medical Association, vol. 313, no. 6, pp. 571-572. https://doi.org/10.1001/jama.2015.8

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