Head and Neck Cancer Research

Head and Neck Cancer Research

Research into head and neck cancer at Penn State Cancer Institute is conducted by the dedicated head and neck cancer team. See current clinical trials and members of that team here.

Clinical Trials

Exercise in Radiation Therapy (EXERT)
Physical Activity Training in Adolescents and Young Adults with Cancer: A Feasibility Study
A Phase II, randomized, open-label three-arm clinical study to evaluate the safety and efficacy of lenvatinib (E7080/MK-7902) in combination with pembrolizumab (MK-3475) versus standard of care chemotherapy and lenvatinib monotherapy in participants with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) that have progressed after platinum therapy and immunotherapy (PD-1/PD-L1 inhibitors) (LEAP-009)
NRG-HN005 - A Randomized Phase II/III Trial of De-intensified Radiation Therapy for Patients with Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer
A Phase II/III Randomized Study of Maintenance Nivolumab versus Observation in Patients with Locally Advanced, Intermediate Risk HPV Positive OPCA
The COVID-19 and Cancer Consortium (CCC19) Registry
NCI COVID-19 in Cancer Patients Study (N-CCaPS): A Longitudinal Natural History Study
Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer
Randomized Phase II/III Trial of Adjuvant Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck
COVID-19 Vaccination in Cancer Patients COVID-19 Vaccination Behavior and Outcomes in Cancer Patients
Head and Neck Cells: Tissue Repository
Understanding Factors that Impact Thyroid Cancer Incidence in Women
Research into head and neck cancer at Penn State Cancer Institute is conducted by the dedicated head and neck cancer team. See current clinical trials and members of that team here.
Exercise in Radiation Therapy (EXERT)
Physical Activity Training in Adolescents and Young Adults with Cancer: A Feasibility Study
A Phase II, randomized, open-label three-arm clinical study to evaluate the safety and efficacy of lenvatinib (E7080/MK-7902) in combination with pembrolizumab (MK-3475) versus standard of care chemotherapy and lenvatinib monotherapy in participants with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) that have progressed after platinum therapy and immunotherapy (PD-1/PD-L1 inhibitors) (LEAP-009)
NRG-HN005 - A Randomized Phase II/III Trial of De-intensified Radiation Therapy for Patients with Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer
A Phase II/III Randomized Study of Maintenance Nivolumab versus Observation in Patients with Locally Advanced, Intermediate Risk HPV Positive OPCA
The COVID-19 and Cancer Consortium (CCC19) Registry
NCI COVID-19 in Cancer Patients Study (N-CCaPS): A Longitudinal Natural History Study
Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer
Randomized Phase II/III Trial of Adjuvant Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck
COVID-19 Vaccination in Cancer Patients COVID-19 Vaccination Behavior and Outcomes in Cancer Patients
Head and Neck Cells: Tissue Repository
Understanding Factors that Impact Thyroid Cancer Incidence in Women

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)