Hong Zheng, MD, PhD - Penn State Cancer Institute
Researcher Profile
Hong Zheng, MD, PhD
Professor, Department of Medicine
Division of Hematology and Oncology
Professor, Department of Molecular and Precision Medicine
Division of Hematology and Oncology
Professor, Department of Molecular and Precision Medicine
Scientific Program:Mechanisms of Carcinogenesis
Disease Teams:
Cancer Institute, Bone Marrow Transplantation Team
Cancer Institute, Immunotherapy Team
Cancer Institute, Leukemia and Lymphoma Team
Cancer Institute, Immunotherapy Team
Cancer Institute, Leukemia and Lymphoma Team
Clinical Trials
Myelomatch, Master Screening And Reassessment Protocol (MSRP) For Tier Advancement In The NCI Myelomatch Clinical Trials
Difference in care and trends in outcomes of adolescent and young adult AML patients treated in pediatric and adult centers
Effective Quadruplet Utilization After Treatment Evaluation (EQUATE): A Randomized Phase 3 Trial for Newly Diagnosed Multiple Myeloma Not Intended for Early Autologous Transplantation
Integration of Differently Regulated Pathways of Selective Targeting of Leukemia Stem Cells in Models of Human Acute Myeloid Leukemia
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adult Patients With Relapsed/Refractory Mantle Cell Lymphoma.
Blood and Bone Marrow Collection from Patients with Hematological Malignancies for Study of Anti-Tumor Immunity
A Randomized Phase II Study of Venetoclax and HMA-based Therapies for the Treatment of Older and Unfit Adults with Newly Diagnosed FLT3-mutated Acute Myeloid Leukemia (AML): A MyeloMATCH Treatment Trial
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
A Randomized Phase II Study Comparing Cytarabine + Daunorubicin (7+3) Vs (Daunorubicin And Cytarabine) Liposome, Cytarabine + Daunorubicin + Venetoclax, Azacitidine + Venetoclax, And (Daunorubicin And Cytarabine) Liposome + Venetoclax In Patients Aged 59 Or Younger Who Are Considered High-Risk (Adverse) Acute Myeloid Leukemia As Determined By Myelomatch; A Myelomatch Clinical Trial
Intermediate-Size Population Expanded Access Program (EAP) for Ciltacabtagene autoleucel (cila-cel) Out-of-Specification (OOS) in patients with Multiple Myeloma
A Phase 3 Randomized Study Comparing Talquetamab in Combination with Pomalidomide (Tal-P),Talquetamab in Combination with Teclistamab (Tal-Tec), and Investigator s Choice of Either Elotuzumab, Pomalidomide, and Dexamethasone (EPd) or Pomalidomide, Bortezomib, and Dexamethasone (PVd) in Participants with Relapsed or Refractory Myeloma who Have Received 1 to 4 Prior Lines of Therapy Including an Anti-CD38 Antibody and Lenalidomide. MonumenTAL-6
Open-Label, Multicenter, Phase 1 Study to Assess the Safety of P-CD19CD20-ALLO1 in Subjects with Selected Relapsed/Refractory B cell Malignancies
MM1YA-CTG01 A Measurable Residual Disease (MRD) Focused, Phase II Study Of Venetoclax Plus Chemotherapy For Newly Diagnosed Younger Patients With Intermediate Risk Acute Myeloid Leukemia: A Tier 1 Myelomatch Clinical Trial
A Phase 3 Randomized, Open-Label, Multicenter Study of Sonrotoclax Plus Anti-CD20 Antibody Therapies Versus Venetoclax Plus Rituximab in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
T-Cell Exhaustion in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.
Assessment of Allogeneic Hematopoietic Cell Transplantation in Medicare Beneficiaries with Multiple Myeloma: A Study to Develop Evidence of Effectiveness for the Centers for Medicare and Medicaid Services (CMS)
Recent Publications
2025
Qian, F, Sarkar, D, Arner, BE, Peduzzi, VM, Bai, Y, Ruan, B, Jia, B, Zheng, H, Paulson, RF & Prabhu, KS 2025, 'Androgen receptor signaling as a new target for intervention in acute myeloid leukemia', Blood Advances, vol. 9, no. 24, pp. 6326-6339. https://doi.org/10.1182/bloodadvances.2024012639
Zhao, C, Jia, B, Jiang, Y, Shike, H, Annageldiyev, C, Cioccio, J, Minagawa, K, Mineishi, S, Ehmann, WC, Schell, TD, Cheng, H & Zheng, H 2025, 'Cytotoxic lymphocytes induced by engineered human dendritic cells mediate potent anti-leukemia activity', Cancer Immunology, Immunotherapy, vol. 74, no. 4, 117. https://doi.org/10.1007/s00262-025-03971-y
Velasco, CM, Inoue, Y, Cioccio, J, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Ehmann, C, Mierski, J, Silar, B, Vajdic, C, Greiner, R, Brown, V, Mineishi, S, Shike, H & Minagawa, K 2025, 'Prior status of graft-versus-host disease affects donor lymphocyte infusion outcomes in patients with relapsed haematological malignancies after allogeneic stem cell transplantation', British Journal of Haematology, vol. 207, no. 2, pp. 515-524. https://doi.org/10.1111/bjh.20215
Venugopal, N, McGowan, A, Inoue, Y, Zheng, H, Cioccio, J, Rakszawski, K, Songdej, N, Nickolich, M, Naik, S, Ehmann, C, Sivik, J, Mierski, J, Silar, B, Vajdic, C, Shike, H, Mineishi, S & Minagawa, K 2025, 'Safety and feasibility of intermediate-dose post-transplant cyclophosphamide for graft-versus-host disease prophylaxis', Annals of Hematology, vol. 104, no. 12, pp. 6451-6462. https://doi.org/10.1007/s00277-025-06657-8
2024
Wang, X, Jia, B, Lee, K, Davis, B, Wen, C, Wang, Y, Zheng, H & Wang, Y 2024, 'Biomimetic Bacterial Capsule for Enhanced Aptamer Display and Cell Recognition', Journal of the American Chemical Society, vol. 146, no. 1, pp. 868-877. https://doi.org/10.1021/jacs.3c11208
Naik, S, Rakszawski, K, Zheng, H, Claxton, D, Minagawa, K & Mineishi, S 2024, 'Clofarabine Preconditioning followed by Allogeneic Transplant Using TBI and Post-Transplant Cyclophosphamide for Relapsed Refractory Leukemia', International journal of molecular sciences, vol. 25, no. 2, 957. https://doi.org/10.3390/ijms25020957
Zulch, E, Inoue, Y, Cioccio, J, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Rybka, W, Ehmann, C, Sivik, J, Mierski, J, Silar, B, Vajdic, C, Greiner, R, Brown, V, Hohl, R, Claxton, D, Shike, H, Paules, CI, Mineishi, S & Minagawa, K 2024, 'Impact of post-transplant cyclophosphamide and splenomegaly on primary graft failure and multi-lineage cytopenia after allogeneic hematopoietic cell transplantation', Leukemia Research, vol. 143, 107530. https://doi.org/10.1016/j.leukres.2024.107530
Lim, ZF, Wu, X, Zhu, L, Albandar, H, Hafez, M, Zhao, C, Almubarak, M, Smolkin, M, Zheng, H, Wen, S & Ma, PC 2024, 'Quantitative peripheral live single T-cell dynamic polyfunctionality profiling predicts lung cancer checkpoint immunotherapy treatment response and clinical outcomes', Translational Lung Cancer Research, vol. 13, no. 12, pp. 3323-3343. https://doi.org/10.21037/tlcr-24-260
Khosla, A, Inoue, Y, Cioccio, J, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Ehmann, C, Claxton, D, Rybka, W, Sivik, J, Mierski, J, Silar, B, Vajdic, C, Hohl, R, Shike, H, Mineishi, S & Minagawa, K 2024, 'Recurrent disease after a matched sibling hematopoietic transplant in an aplastic anemia patient with a disease risk allele, HLA-B*40:02', Blood Transfusion, vol. 22, no. 6, pp. 525-528. https://doi.org/10.2450/BloodTransfus.674
Zhang, R, Shang, Y, Cioccio, J, Rakszawski, K, Nickolich, M, Ehmann, C, Inoue, Y, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Liao, J, Greiner, R, Brown, V, Claxton, D, Ning, J, Zhou, S, Mineishi, S, Minagawa, K & Shike, H 2024, 'Sensitivity and Specificity of Chimerism Tests in Predicting Leukemia Relapse Using Increasing Mixed Chimerism', Journal of Molecular Diagnostics, vol. 26, no. 12, pp. 1159-1170. https://doi.org/10.1016/j.jmoldx.2024.09.003
Guare, EG, Hale, CM, Sivik, J, Lehman, E, Inoue, Y, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Claxton, D, Rybka, W, Hohl, R, Mineishi, S, Minagawa, K & Paules, CI 2024, 'The addition of doxycycline to fluoroquinolones for bacterial prophylaxis in autologous stem cell transplantation for multiple myeloma', Transplant Infectious Disease, vol. 26, no. 2, e14241. https://doi.org/10.1111/tid.14241
2023
Jia, B, Zhao, C, Minagawa, K, Shike, H, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Wang, M, Schell, TD, Prabhu, KS, Paulson, RF, Zhang, Y, Shultz, LD & Zheng, H 2023, 'Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model', Journal of Immunology, vol. 211, no. 9, pp. 1426-1437. https://doi.org/10.4049/jimmunol.2300111
Zhou, H, Jia, B, Annageldiyev, C, Minagawa, K, Zhao, C, Mineishi, S, Ehmann, WC, Naik, SG, Cioccio, J, Wirk, B, Songdej, N, Rakszawski, KL, Nickolich, MS, Shen, J & Zheng, H 2023, 'CD26lowPD-1+ CD8 T cells are terminally exhausted and associated with leukemia progression in acute myeloid leukemia', Frontiers in immunology, vol. 14, 1169144. https://doi.org/10.3389/fimmu.2023.1169144
Wang, X, Wang, Y, Lee, K, Davis, B, Wen, C, Jia, B, Zheng, H, Dong, C & Wang, Y 2024, 'Display of Polyvalent Hybrid Antibodies on the Cell Surface for Enhanced Cell Recognition', Small Methods, vol. 8, no. 9, 2301331. https://doi.org/10.1002/smtd.202301331
Potiaumpai, M, Schmitz, KH, Mineishi, S, Naik, S, Wirk, B, Rakszawski, K, Ehmann, WC, Claxton, D, Nickolich, M, Zemel, BS & Zheng, H 2023, 'IMPROVE-BMT: A protocol for a pilot randomised controlled trial of prehabilitation exercise for adult haematopoietic stem cell transplant recipients', BMJ open, vol. 13, no. 1, e066841. https://doi.org/10.1136/bmjopen-2022-066841
Wang, B, Zhu, L, Jia, B, Zhao, C, Zhang, J, Li, F, Li, J, Ding, N, Zhang, C, Hao, Y, Tong, S, Wang, J, Li, G, Fan, Y, Zhang, H, Li, R, Du, J, Kong, Y, Zhang, Y, Yang, X, Han, J, Yu, Z, Du, Z, Zheng, H, Kosan, C, Li, A, Chen, C, Ma, Y & Zeng, H 2023, 'Sepsis induces non-classic innate immune memory in granulocytes', Cell Reports, vol. 42, no. 9, 113044. https://doi.org/10.1016/j.celrep.2023.113044
2022
Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2023, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology, vol. 102, no. 3, pp. 613-620. https://doi.org/10.1007/s00277-022-05077-2
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Pizzola, CJ, Cioccio, J, Rakszawski, KL, Nickolich, M, Ehmann, WC, Rybka, WB, Wirk, B, Naik, S, Zheng, H, Silar, B, Shike, H, Zhou, S, Mineishi, S, Minagawa, K & Claxton, DF 2022, 'Non-myeloablative allogeneic stem cell transplant with fludarabine and reduced dose cyclophosphamide in acute myeloid leukemia for older adults with comorbidities', Bone Marrow Transplantation, vol. 57, no. 11, pp. 1743-1745. https://doi.org/10.1038/s41409-022-01821-4
Zhao, C, Bartock, M, Jia, B, Shah, N, Claxton, DF, Wirk, B, Rakszawski, KL, Nickolich, MS, Naik, SG, Rybka, WB, Ehmann, WCC, Hohl, RJ, Valentin, J, Bernas-Peterson, M, Gerber, EM, Zimmerman, M, Mierski, JA, Mineishi, S & Zheng, H 2022, 'Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant', Journal of Hematology and Oncology, vol. 15, no. 1, 64. https://doi.org/10.1186/s13045-022-01287-3
Xu, J, Song, F, Lyu, H, Kobayashi, M, Zhang, B, Zhao, Z, Hou, Y, Wang, X, Luan, Y, Jia, B, Stasiak, L, Wong, JHY, Wang, Q, Jin, Q, Jin, Q, Fu, Y, Yang, H, Hardison, RC, Dovat, S, Platanias, LC, Diao, Y, Yang, Y, Yamada, T, Viny, AD, Levine, RL, Claxton, D, Broach, JR, Zheng, H & Yue, F 2022, 'Subtype-specific 3D genome alteration in acute myeloid leukaemia', Nature, vol. 611, no. 7935, pp. 387-398. https://doi.org/10.1038/s41586-022-05365-x