Researcher Profile

Researcher Profile

Witold Rybka, MD, FRCPC

Witold Rybka, MD, FRCPC

Professor, Department of Medicine
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Bone Marrow Transplantation
Leukemia and Lymphoma
Survivorship
wbr2@psu.edu

Research Interests

  • Transplants
  • Bone Marrow
  • Therapeutics
  • Acute Myeloid Leukemia
  • Bone Marrow Transplantation
  • T-Lymphocytes
  • Tissue Donors
  • Stem Cells
  • Allogeneic Cells
  • Drug Therapy
  • Cyclophosphamide
  • Recurrence

Clinical Trials

Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.
Blood and Bone Marrow Collection from Patients with Hematological Malignancies for Study of Anti-Tumor Immunity
bcr-abl PCR response to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia in Stable Chronic Phase.
Assessment of Allogeneic Hematopoietic Cell Transplantation in Medicare Beneficiaries with Multiple Myeloma: A Study to Develop Evidence of Effectiveness for the Centers for Medicare and Medicaid Services (CMS)
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
T-Cell Exhaustion in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia

Recent Publications

2022

Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2022, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology. https://doi.org/10.1007/s00277-022-05077-2
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Pizzola, CJ, Cioccio, J, Rakszawski, KL, Nickolich, M, Ehmann, WC, Rybka, WB, Wirk, B, Naik, S, Zheng, H, Silar, B, Shike, H, Zhou, S, Mineishi, S, Minagawa, K & Claxton, DF 2022, 'Non-myeloablative allogeneic stem cell transplant with fludarabine and reduced dose cyclophosphamide in acute myeloid leukemia for older adults with comorbidities', Bone Marrow Transplantation, vol. 57, no. 11, pp. 1743-1745. https://doi.org/10.1038/s41409-022-01821-4
Gregory, GP, Kumar, S, Wang, D, Mahadevan, D, Walker, P, Wagner-Johnston, N, Escobar, C, Bannerji, R, Bhutani, D, Chang, J, Hernandez-Ilizaliturri, FJ, Klein, A, Pagel, JM, Rybka, W, Yee, AJ, Mohrbacher, A, Huang, M, Farooqui, M, Marinello, P & Quach, H 2022, 'Pembrolizumab plus dinaciclib in patients with hematologic malignancies: the phase 1b KEYNOTE-155 study', Blood Advances, vol. 6, no. 4, pp. 1232-1242. https://doi.org/10.1182/bloodadvances.2021005872
Zhao, C, Bartock, M, Jia, B, Shah, N, Claxton, DF, Wirk, B, Rakszawski, KL, Nickolich, MS, Naik, SG, Rybka, WB, Ehmann, WCC, Hohl, RJ, Valentin, J, Bernas-Peterson, M, Gerber, EM, Zimmerman, M, Mierski, JA, Mineishi, S & Zheng, H 2022, 'Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant', Journal of Hematology and Oncology, vol. 15, no. 1, 64. https://doi.org/10.1186/s13045-022-01287-3

2021

Percival, ME, Wang, HL, Zhang, MJ, Saber, W, de Lima, M, Litzow, M, Kebriaei, P, Abdel-Azim, H, Adekola, K, Aljurf, M, Bacher, U, Badawy, SM, Beitinjaneh, A, Bejanyan, N, Bhatt, V, Byrne, M, Cahn, JY, Castillo, P, Chao, N, Chhabra, S, Copelan, E, Cutler, C, DeFilipp, Z, Dias, A, Diaz, MA, Estey, E, Farhadfar, N, Frangoul, HA, Freytes, CO, Gale, RP, Ganguly, S, Gowda, L, Grunwald, M, Hossain, N, Kamble, RT, Kanakry, CG, Kansagra, A, Kharfan-Dabaja, MA, Krem, M, Lazarus, HM, Lee, JW, Liesveld, JL, Lin, R, Liu, H, McGuirk, J, Munker, R, Murthy, HS, Nathan, S, Nishihori, T, Olsson, RF, Palmisiano, N, Passweg, JR, Prestidge, T, Ringdén, O, Rizzieri, DA, Rybka, WB, Savoie, ML, Schultz, KR, Seo, S, Sharma, A, Solh, M, Strair, R, van der Poel, M, Verdonck, LF, Yared, JA, Weisdorf, D & Sandmaier, BM 2021, 'Correction to: Impact of depth of clinical response on outcomes of acute myeloid leukemia patients in first complete remission who undergo allogeneic hematopoietic cell transplantation (Bone Marrow Transplantation, (2021), 56, 9, (2108-2117), 10.1038/s41409-021-01261-6)', Bone Marrow Transplantation, vol. 56, no. 9, pp. 2319. https://doi.org/10.1038/s41409-021-01353-3
Percival, ME, Wang, HL, Zhang, MJ, Saber, W, de Lima, M, Litzow, M, Kebriaei, P, Abdel-Azim, H, Adekola, K, Aljurf, M, Bacher, U, Badawy, SM, Beitinjaneh, A, Bejanyan, N, Bhatt, V, Byrne, M, Cahn, JY, Castillo, P, Chao, N, Chhabra, S, Copelan, E, Cutler, C, DeFilipp, Z, Dias, A, Diaz, MA, Estey, E, Farhadfar, N, Frangoul, HA, Freytes, CO, Gale, RP, Ganguly, S, Gowda, L, Grunwald, M, Hossain, N, Kamble, RT, Kanakry, CG, Kansagra, A, Kharfan-Dabaja, MA, Krem, M, Lazarus, HM, Lee, JW, Liesveld, JL, Lin, R, Liu, H, McGuirk, J, Munker, R, Murthy, HS, Nathan, S, Nishihori, T, Olsson, RF, Palmisiano, N, Passweg, JR, Prestidge, T, Ringdén, O, Rizzieri, DA, Rybka, WB, Savoie, ML, Schultz, KR, Seo, S, Sharma, A, Solh, M, Strair, R, van der Poel, M, Verdonck, LF, Yared, JA, Weisdorf, D & Sandmaier, BM 2021, 'Impact of depth of clinical response on outcomes of acute myeloid leukemia patients in first complete remission who undergo allogeneic hematopoietic cell transplantation', Bone Marrow Transplantation, vol. 56, no. 9, pp. 2108-2117. https://doi.org/10.1038/s41409-021-01261-6
Shah, N, Rakszawski, K, Nickolich, M, Ehmann, C, Wirk, B, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Mackey, G, Greiner, R, Brown, V, Claxton, D, Mineishi, S & Minagawa, K 2021, 'Improved outcome in AML relapse after allogeneic transplant with high-intensity chemotherapy followed by 2nd allogeneic stem cell transplant or donor lymphocyte infusion', Annals of Hematology, vol. 100, no. 10, pp. 2585-2592. https://doi.org/10.1007/s00277-021-04616-7
Luger, SM, Wang, VX, Rowe, JM, Litzow, MR, Paietta, E, Ketterling, RP, Lazarus, H, Rybka, WB, Craig, MD, Karp, J, Cooper, BW, Makary, AZ, Kaminer, LS, Appelbaum, FR, Larson, RA & Tallman, MS 2021, 'Tipifarnib as maintenance therapy did not improve disease-free survival in patients with acute myelogenous leukemia at high risk of relapse: Results of the phase III randomized E2902 trial', Leukemia Research, vol. 111, 106736. https://doi.org/10.1016/j.leukres.2021.106736
Gvozdjan, K, Casey, H, Mowery, C, Kumer, L, Fisher, C, Tyler, J, Bayerl, MG, Malysz, J, Naik, S, Rybka, W, Ehmann, C, Claxton, D, Mineishi, S, Baker, M, Hong, Z & Shike, H 2021, 'Unexpected Short-Tandem-Repeat Patterns in Post-Transplant Chimerism Testing: Investigation of 3 Cases with Help from Forensic Science', Laboratory Medicine, vol. 51, no. 6, pp. 635-641. https://doi.org/10.1093/LABMED/LMAA022

2020

Strickland, SA, Wang, XV, Cerny, J, Rowe, JM, Rybka, W, Tallman, MS, Litzow, M & Lazarus, HM 2020, 'A novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia', Leukemia and Lymphoma, vol. 61, no. 9, pp. 2191-2199. https://doi.org/10.1080/10428194.2020.1762878
Zheng, H, Mineishi, S, Claxton, D, Zhu, J, Zhao, C, Jia, B, Ehmann, WC, Rybka, WB, Naik, S, Songdej, N, Drabick, JJ & Hohl, RJ 2021, 'A phase I clinical trial of avelumab in combination with decitabine as first line treatment of unfit patients with acute myeloid leukemia', American Journal of Hematology, vol. 96, no. 2, pp. E46-E50. https://doi.org/10.1002/ajh.26043

2019

Pulsipher, MA, Logan, BR, Chitphakdithai, P, Kiefer, DM, Riches, ML, Rizzo, JD, Anderlini, P, Leitman, SF, Varni, JW, Kobusingye, H, Besser, RAM, Miller, JP, Drexler, RJ, Abdel-Mageed, A, Ahmed, IA, Akard, LP, Artz, AS, Ball, ED, Bayer, RL, Bigelow, C, Bolwell, BJ, Broun, ER, Bunin, NJ, Delgado, DC, Duckworth, K, Dvorak, CC, Hahn, TE, Haight, AE, Hari, PN, Hayes-Lattin, BM, Jacobsohn, DA, Jakubowski, AA, Kasow, KA, Lazarus, HM, Liesveld, JL, Linenberger, M, Litzow, MR, Longo, W, Magalhaes-Silverman, M, McCarty, JM, McGuirk, JP, Mori, S, Prasad, VK, Rowley, SD, Rybka, WB, Sahdev, I, Schriber, JR, Selby, GB, Shaughnessy, PJ, Shenoy, S, Spitzer, T, Tse, WT, Uberti, JP, Vusirikala, M, Waller, EK, Weisdorf, DJ, Yanik, GA, Navarro, WH, Horowitz, MM, Switzer, GE, Shaw, BE & Confer, DL 2019, 'Effect of Aging and Predonation Comorbidities on the Related Peripheral Blood Stem Cell Donor Experience: Report from the Related Donor Safety Study', Biology of Blood and Marrow Transplantation, vol. 25, no. 4, pp. 699-711. https://doi.org/10.1016/j.bbmt.2018.11.004
Jia, B, Zhao, C, Rakszawski, KL, Claxton, DF, Christopher Ehmann, W, Rybka, WB, Mineishi, S, Wang, M, Shike, H, Bayerl, MG, Sivik, JM, Schell, TD, Drabick, JJ, Hohl, RJ & Zheng, H 2019, 'Eomes+T-betlow CD8+ T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia', Cancer Research, vol. 79, no. 7, pp. 1635-1645. https://doi.org/10.1158/0008-5472.CAN-18-3107
Zhao, C, Jia, B, Wang, M, Schell, TD, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Naik, S, Songdej, N, Sivik, JM, Hohl, RJ, Zeng, H & Zheng, H 2020, 'Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML', British Journal of Haematology, vol. 188, no. 5, pp. 674-684. https://doi.org/10.1111/bjh.16228
Pulsipher, MA, Logan, BR, Kiefer, DM, Chitphakdithai, P, Riches, ML, Rizzo, JD, Anderlini, P, Leitman, SF, Kobusingye, H, Besser, RM, Miller, JP, Drexler, RJ, Abdel-Mageed, A, Ahmed, IA, Akard, LP, Artz, AS, Ball, ED, Bayer, RL, Bigelow, C, Bolwell, BJ, Broun, ER, Delgado, DC, Duckworth, K, Dvorak, CC, Hahn, TE, Haight, AE, Hari, PN, Hayes-Lattin, BM, Jacobsohn, DA, Jakubowski, AA, Kasow, KA, Lazarus, HM, Liesveld, JL, Linenberger, M, Litzow, MR, Longo, W, Magalhaes-Silverman, M, McCarty, JM, McGuirk, JP, Mori, S, Parameswaran, V, Prasad, VK, Rowley, SD, Rybka, WB, Sahdev, I, Schriber, JR, Selby, GB, Shaughnessy, PJ, Shenoy, S, Spitzer, T, Tse, WT, Uberti, JP, Vusirikala, M, Waller, EK, Weisdorf, DJ, Yanik, GA, Navarro, WH, Horowitz, MM, Switzer, GE, Confer, DL & Shaw, BE 2019, 'Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors', Haematologica, vol. 104, no. 4, pp. 844-854. https://doi.org/10.3324/haematol.2018.200121

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)