Researcher Profile

Researcher Profile

Witold Rybka, MD, FRCPC

Witold Rybka, MD, FRCPC

Professor, Department of Medicine
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Bone Marrow Transplantation
Leukemia and Lymphoma
Survivorship
wbr2@psu.edu

Research Interests

  • Bone Marrow
  • Transplants
  • Therapeutics
  • Bone Marrow Transplantation
  • Acute Myeloid Leukemia
  • T-Lymphocytes
  • Drug Therapy
  • Tissue Donors
  • Stem Cells
  • Cyclophosphamide
  • Breast Neoplasms
  • Leukemia

Clinical Trials

Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.
Blood and Bone Marrow Collection from Patients with Hematological Malignancies for Study of Anti-Tumor Immunity
bcr-abl PCR response to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia in Stable Chronic Phase.
Assessment of Allogeneic Hematopoietic Cell Transplantation in Medicare Beneficiaries with Multiple Myeloma: A Study to Develop Evidence of Effectiveness for the Centers for Medicare and Medicaid Services (CMS)
Managed Access Program (MAP) to provide access to CTL019, for acute lymphoblastic leukemia (ALL) or large B-cell lymphoma patients with out of specification leukapheresis product and/or manufactured tisagenlecleucel out of specification for commercial release
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
T-Cell Exhaustion in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation

Recent Publications

2021

Gvozdjan, K, Casey, H, Mowery, C, Kumer, L, Fisher, C, Tyler, J, Bayerl, MG, Malysz, J, Naik, S, Rybka, W, Ehmann, C, Claxton, D, Mineishi, S, Baker, M, Hong, Z & Shike, H 2021, 'Unexpected Short-Tandem-Repeat Patterns in Post-Transplant Chimerism Testing: Investigation of 3 Cases with Help from Forensic Science', Laboratory Medicine, vol. 51, no. 6, pp. 635-641. https://doi.org/10.1093/LABMED/LMAA022

2020

Strickland, SA, Wang, XV, Cerny, J, Rowe, JM, Rybka, W, Tallman, MS, Litzow, M & Lazarus, HM 2020, 'A novel PrECOG (PrE0901) dose-escalation trial using eltrombopag: enhanced platelet recovery during consolidation therapy in acute myeloid leukemia', Leukemia and Lymphoma, vol. 61, no. 9, pp. 2191-2199. https://doi.org/10.1080/10428194.2020.1762878
Zheng, H, Mineishi, S, Claxton, D, Zhu, J, Zhao, C, Jia, B, Ehmann, WC, Rybka, WB, Naik, S, Songdej, N, Drabick, JJ & Hohl, RJ 2021, 'A phase I clinical trial of avelumab in combination with decitabine as first line treatment of unfit patients with acute myeloid leukemia', American Journal of Hematology, vol. 96, no. 2, pp. E46-E50. https://doi.org/10.1002/ajh.26043

2019

Pulsipher, MA, Logan, BR, Chitphakdithai, P, Kiefer, DM, Riches, ML, Rizzo, JD, Anderlini, P, Leitman, SF, Varni, JW, Kobusingye, H, Besser, RAM, Miller, JP, Drexler, RJ, Abdel-Mageed, A, Ahmed, IA, Akard, LP, Artz, AS, Ball, ED, Bayer, RL, Bigelow, C, Bolwell, BJ, Broun, ER, Bunin, NJ, Delgado, DC, Duckworth, K, Dvorak, CC, Hahn, TE, Haight, AE, Hari, PN, Hayes-Lattin, BM, Jacobsohn, DA, Jakubowski, AA, Kasow, KA, Lazarus, HM, Liesveld, JL, Linenberger, M, Litzow, MR, Longo, W, Magalhaes-Silverman, M, McCarty, JM, McGuirk, JP, Mori, S, Prasad, VK, Rowley, SD, Rybka, WB, Sahdev, I, Schriber, JR, Selby, GB, Shaughnessy, PJ, Shenoy, S, Spitzer, T, Tse, WT, Uberti, JP, Vusirikala, M, Waller, EK, Weisdorf, DJ, Yanik, GA, Navarro, WH, Horowitz, MM, Switzer, GE, Shaw, BE & Confer, DL 2019, 'Effect of Aging and Predonation Comorbidities on the Related Peripheral Blood Stem Cell Donor Experience: Report from the Related Donor Safety Study', Biology of Blood and Marrow Transplantation, vol. 25, no. 4, pp. 699-711. https://doi.org/10.1016/j.bbmt.2018.11.004
Jia, B, Zhao, C, Rakszawski, KL, Claxton, DF, Christopher Ehmann, W, Rybka, WB, Mineishi, S, Wang, M, Shike, H, Bayerl, MG, Sivik, JM, Schell, TD, Drabick, JJ, Hohl, RJ & Zheng, H 2019, 'Eomes+T-betlow CD8+ T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia', Cancer Research, vol. 79, no. 7, pp. 1635-1645. https://doi.org/10.1158/0008-5472.CAN-18-3107
Zhao, C, Jia, B, Wang, M, Schell, TD, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Naik, S, Songdej, N, Sivik, JM, Hohl, RJ, Zeng, H & Zheng, H 2020, 'Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML', British Journal of Haematology, vol. 188, no. 5, pp. 674-684. https://doi.org/10.1111/bjh.16228
Pulsipher, MA, Logan, BR, Kiefer, DM, Chitphakdithai, P, Riches, ML, Rizzo, JD, Anderlini, P, Leitman, SF, Kobusingye, H, Besser, RM, Miller, JP, Drexler, RJ, Abdel-Mageed, A, Ahmed, IA, Akard, LP, Artz, AS, Ball, ED, Bayer, RL, Bigelow, C, Bolwell, BJ, Broun, ER, Delgado, DC, Duckworth, K, Dvorak, CC, Hahn, TE, Haight, AE, Hari, PN, Hayes-Lattin, BM, Jacobsohn, DA, Jakubowski, AA, Kasow, KA, Lazarus, HM, Liesveld, JL, Linenberger, M, Litzow, MR, Longo, W, Magalhaes-Silverman, M, McCarty, JM, McGuirk, JP, Mori, S, Parameswaran, V, Prasad, VK, Rowley, SD, Rybka, WB, Sahdev, I, Schriber, JR, Selby, GB, Shaughnessy, PJ, Shenoy, S, Spitzer, T, Tse, WT, Uberti, JP, Vusirikala, M, Waller, EK, Weisdorf, DJ, Yanik, GA, Navarro, WH, Horowitz, MM, Switzer, GE, Confer, DL & Shaw, BE 2019, 'Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors', Haematologica, vol. 104, no. 4, pp. 844-854. https://doi.org/10.3324/haematol.2018.200121

2018

Litzow, MR, Wang, XV, Carroll, MP, Karp, JE, Ketterling, RP, Zhang, Y, Kaufmann, SH, Lazarus, HM, Luger, SM, Paietta, EM, Pratz, KW, Tun, HW, Altman, JK, Broun, ER, Rybka, WB, Rowe, JM & Tallman, MS 2019, 'A randomized trial of three novel regimens for recurrent acute myeloid leukemia demonstrates the continuing challenge of treating this difficult disease', American Journal of Hematology, vol. 94, no. 1, pp. 111-117. https://doi.org/10.1002/ajh.25333
Jia, B, Wang, L, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Rizvi, S, Shike, H, Bayerl, M, Schell, TD, Hohl, RJ & Zheng, H 2018, 'Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients', Blood Cancer Journal, vol. 8, no. 3, 34. https://doi.org/10.1038/s41408-018-0069-4
Norkin, M, Shaw, BE, Brazauskas, R, Tecca, HR, Leather, HL, Gea-Banacloche, J, T. Kamble, R, DeFilipp, Z, Jacobsohn, DA, Ringden, O, Inamoto, Y, A. Kasow, K, Buchbinder, D, Shaw, P, Hematti, P, Schears, R, Badawy, SM, Lazarus, HM, Bhatt, N, Horn, B, Chhabra, S, M. Page, K, Hamilton, B, Hildebrandt, GC, Yared, JA, Agrawal, V, M. Beitinjaneh, A, Majhail, N, Kindwall-Keller, T, Olsson, RF, Schoemans, H, Gale, RP, Ganguly, S, A. Ahmed, I, Schouten, HC, L. Liesveld, J, Khera, N, Steinberg, A, Shah, AJ, Solh, M, Marks, DI, Rybka, W, Aljurf, M, Dietz, AC, Gergis, U, George, B, Seo, S, Flowers, MED, Battiwalla, M, Savani, BN, Riches, ML & Wingard, JR 2019, 'Characteristics of Late Fatal Infections after Allogeneic Hematopoietic Cell Transplantation', Biology of Blood and Marrow Transplantation, vol. 25, no. 2, pp. 362-368. https://doi.org/10.1016/j.bbmt.2018.09.031
Gooptu, M, Kim, HT, Chen, YB, Rybka, W, Artz, A, Boyer, M, Johnston, L, McGuirk, J, Shea, TC, Jagasia, M, Shaughnessy, PJ, Reynolds, CG, Fields, M, Alyea, EP, Ho, VT, Glavin, F, Dipersio, JF, Westervelt, P, Ritz, J & Soiffer, RJ 2018, 'Effect of Antihuman T Lymphocyte Globulin on Immune Recovery after Myeloablative Allogeneic Stem Cell Transplantation with Matched Unrelated Donors: Analysis of Immune Reconstitution in a Double-Blind Randomized Controlled Trial', Biology of Blood and Marrow Transplantation, vol. 24, no. 11, pp. 2216-2223. https://doi.org/10.1016/j.bbmt.2018.07.002
V212 Protocol 001 Trial Team 2018, 'Inactivated varicella zoster vaccine in autologous haemopoietic stem-cell transplant recipients: an international, multicentre, randomised, double-blind, placebo-controlled trial', The Lancet, vol. 391, no. 10135, pp. 2116-2127. https://doi.org/10.1016/S0140-6736(18)30631-7
Wang, L, Jia, B, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Naik, S, Khawaja, MR, Sivik, J, Han, J, Hohl, RJ & Zheng, H 2018, 'VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML', OncoImmunology, vol. 7, no. 9, e1469594. https://doi.org/10.1080/2162402X.2018.1469594

2017

Zhu, L, Kong, Y, Zhang, J, Claxton, DF, Ehmann, WC, Rybka, WB, Palmisiano, ND, Wang, M, Jia, B, Bayerl, M, Schell, TD, Hohl, RJ, Zeng, H & Zheng, H 2017, 'Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia', Journal of Hematology and Oncology, vol. 10, no. 1, 124. https://doi.org/10.1186/s13045-017-0486-z
Teye, EK, Sido, A, Xin, P, Finnberg, NK, Gokare, P, Kawasawa, YI, Salzberg, AC, Shimko, S, Bayerl, M, Ehmann, WC, Claxton, DF, Rybka, WB, Drabick, JJ, Wang, HG, Abraham, T, El-Deiry, WS, Brodsky, RA, J.Hohl, R & Pu, JJ 2017, 'PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features', Oncotarget, vol. 8, no. 18, pp. 29887-29905. https://doi.org/10.18632/oncotarget.15136
Soiffer, RJ, Kim, HT, McGuirk, J, Horwitz, ME, Johnston, L, Patnaik, MM, Rybka, W, Artz, A, Porter, DL, Shea, TC, Boyer, MW, Maziarz, RT, Shaughnessy, PJ, Gergis, U, Safah, H, Reshef, R, Dipersio, JF, Stiff, PJ, Vusirikala, M, Szer, J, Holter, J, Levine, JD, Martin, PJ, Pidala, JA, Lewis, ID, Ho, VT, Alyea, EP, Ritz, J, Glavin, F, Westervelt, P, Jagasia, MH & Chen, YB 2017, 'Prospective, randomized, double-blind, phase III clinical trial of anti-T-lymphocyte globulin to assess impact on chronic graft-versus-host disease-free survival in patients undergoing HLA-matched unrelated myeloablative hematopoietic cell transplantation', Journal of Clinical Oncology, vol. 35, no. 36, pp. 4003-4011. https://doi.org/10.1200/JCO.2017.75.8177

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)