Researcher Profile

Researcher Profile

Witold Rybka, MD, FRCPC

Witold Rybka, MD, FRCPC

Professor, Department of Medicine
Division of Hematology and Oncology
Scientific Program:Experimental Therapeutics
Disease Teams:
Bone Marrow Transplantation
Leukemia and Lymphoma
Survivorship
wbr2@psu.edu

Research Interests

  • Bone Marrow Transplantation
  • Bone Marrow
  • Transplants
  • Therapeutics
  • T-Lymphocytes
  • Leukemia
  • Tissue Donors
  • Cyclophosphamide
  • Acute Myeloid Leukemia
  • Stem Cells
  • Transplantation
  • Drug Therapy

Clinical Trials

MATCH Treatment Subprotocol C2: Crizotinib in Patients with Tumors with MET Exon 14 Deletion
MATCH Treatment Subprotocol E: AZD9291 in Patients with Tumors Having EGFR T790M Mutations (Except Non-Small Cell Lung Cancer) or Rare Activating Mutations of EGFR
MATCH Treatment Subprotocol F: Crizotinib in Patients with Tumors (Other Than Adenocarcinoma of Lung or ALCL) with ALK Rearrangements
MATCH Treatment Subprotocol G: Phase II Study of Crizotinib in Patients with ROS1 Translocations (Other Than Patients with Non-Small Cell Lung Cancer)
MATCH Treatment Subprotocol L: Phase II Study of MLN0128 (TAK-228) in Patients with Tumors with mTOR Mutations
MATCH Treatment Subprotocol M: Phase II Study of MLN0128 (TAK-228) in Patients with Tumors with TSC1 or TSC2 Mutations
MATCH Treatment Subprotocol T: GDC-0449 (vismodegib) in Patients with Tumors (except basal cell skin carcinoma) with Smoothened (SMO) or Patched 1 (PTCH1) Mutations
MATCH Treatment Subprotocol V: Phase II Study of Sunitinib in Patients with Tumors with c-Kit Mutations (Excluding GIST, Renal Cell Carcinoma or Pancreatic Neuroendocrine Tumor).
Blood and Bone Marrow Collection from Patients with Hematological Malignancies for Study of Anti-Tumor Immunity
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
T-Cell Exhaustion in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.

Recent Publications

2019

Pulsipher, MA, Logan, BR, Chitphakdithai, P, Kiefer, DM, Riches, ML, Rizzo, JD, Anderlini, P, Leitman, SF, Varni, JW, Kobusingye, H, Besser, RAM, Miller, JP, Drexler, RJ, Abdel-Mageed, A, Ahmed, IA, Akard, LP, Artz, AS, Ball, ED, Bayer, RL, Bigelow, C, Bolwell, BJ, Broun, ER, Bunin, NJ, Delgado, DC, Duckworth, K, Dvorak, CC, Hahn, TE, Haight, AE, Hari, PN, Hayes-Lattin, BM, Jacobsohn, DA, Jakubowski, AA, Kasow, KA, Lazarus, HM, Liesveld, JL, Linenberger, M, Litzow, MR, Longo, W, Magalhaes-Silverman, M, McCarty, JM, McGuirk, JP, Mori, S, Prasad, VK, Rowley, SD, Rybka, W, Sahdev, I, Schriber, JR, Selby, GB, Shaughnessy, PJ, Shenoy, S, Spitzer, T, Tse, WT, Uberti, JP, Vusirikala, M, Waller, EK, Weisdorf, DJ, Yanik, GA, Navarro, WH, Horowitz, MM, Switzer, GE, Shaw, BE & Confer, DL 2019, 'Effect of Aging and Predonation Comorbidities on the Related Peripheral Blood Stem Cell Donor Experience: Report from the Related Donor Safety Study', Biology of Blood and Marrow Transplantation, vol. 25, no. 4, pp. 699-711. https://doi.org/10.1016/j.bbmt.2018.11.004
Jia, B, Zhao, C, Rakszawski, KL, Claxton, D, Ehmann, WC, Rybka, W, Mineishi, S, Wang, M, Shike, H, Bayerl, M, Sivik, JM, Schell, T, Drabick, J, Hohl, R & Zheng, H 2019, 'Eomes+T-betlow CD8+ T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia', Cancer Research, vol. 79, no. 7, pp. 1635-1645. https://doi.org/10.1158/0008-5472.CAN-18-3107
Pulsipher, MA, Logan, BR, Kiefer, DM, Chitphakdithai, P, Riches, ML, Rizzo, JD, Anderlini, P, Leitman, SF, Kobusingye, H, Besser, RM, Miller, JP, Drexler, RJ, Abdel-Mageed, A, Ahmed, IA, Akard, LP, Artz, AS, Ball, ED, Bayer, RL, Bigelow, C, Bolwell, BJ, Broun, ER, Delgado, DC, Duckworth, K, Dvorak, CC, Hahn, TE, Haight, AE, Hari, PN, Hayes-Lattin, BM, Jacobsohn, DA, Jakubowski, AA, Kasow, KA, Lazarus, HM, Liesveld, JL, Linenberger, M, Litzow, MR, Longo, W, Magalhaes-Silverman, M, McCarty, JM, McGuirk, JP, Mori, S, Parameswaran, V, Prasad, VK, Rowley, SD, Rybka, W, Sahdev, I, Schriber, JR, Selby, GB, Shaughnessy, PJ, Shenoy, S, Spitzer, T, Tse, WT, Uberti, JP, Vusirikala, M, Waller, EK, Weisdorf, DJ, Yanik, GA, Navarro, WH, Horowitz, MM, Switzer, GE, Confer, DL & Shaw, BE 2019, 'Related peripheral blood stem cell donors experience more severe symptoms and less complete recovery at one year compared to unrelated donors', Haematologica, vol. 104, no. 4, pp. 844-854. https://doi.org/10.3324/haematol.2018.200121

2018

Litzow, MR, Wang, XV, Carroll, MP, Karp, JE, Ketterling, RP, Zhang, Y, Kaufmann, SH, Lazarus, HM, Luger, SM, Paietta, EM, Pratz, KW, Tun, HW, Altman, JK, Broun, ER, Rybka, W, Rowe, JM & Tallman, MS 2019, 'A randomized trial of three novel regimens for recurrent acute myeloid leukemia demonstrates the continuing challenge of treating this difficult disease', American Journal of Hematology, vol. 94, no. 1, pp. 111-117. https://doi.org/10.1002/ajh.25333
Jia, B, Wang, L, Claxton, D, Ehmann, WC, Rybka, W, Mineishi, S, Rizvi, S, Shike, H, Bayerl, M, Schell, T, Hohl, R & Zheng, H 2018, 'Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients', Blood Cancer Journal, vol. 8, no. 3, 34. https://doi.org/10.1038/s41408-018-0069-4
Norkin, M, Shaw, BE, Brazauskas, R, Tecca, HR, Leather, HL, Gea-Banacloche, J, T. Kamble, R, DeFilipp, Z, Jacobsohn, DA, Ringden, O, Inamoto, Y, A. Kasow, K, Buchbinder, D, Shaw, P, Hematti, P, Schears, R, Badawy, SM, Lazarus, HM, Bhatt, N, Horn, B, Chhabra, S, M. Page, K, Hamilton, B, Hildebrandt, GC, Yared, JA, Agrawal, V, M. Beitinjaneh, A, Majhail, N, Kindwall-Keller, T, Olsson, RF, Schoemans, H, Gale, RP, Ganguly, S, A. Ahmed, I, Schouten, HC, L. Liesveld, J, Khera, N, Steinberg, A, Shah, AJ, Solh, M, Marks, DI, Rybka, W, Aljurf, M, Dietz, AC, Gergis, U, George, B, Seo, S, Flowers, MED, Battiwalla, M, Savani, BN, Riches, ML & Wingard, JR 2019, 'Characteristics of Late Fatal Infections after Allogeneic Hematopoietic Cell Transplantation', Biology of Blood and Marrow Transplantation, vol. 25, no. 2, pp. 362-368. https://doi.org/10.1016/j.bbmt.2018.09.031
Gooptu, M, Kim, HT, Chen, YB, Rybka, W, Artz, A, Boyer, M, Johnston, L, McGuirk, J, Shea, TC, Jagasia, M, Shaughnessy, PJ, Reynolds, CG, Fields, M, Alyea, EP, Ho, VT, Glavin, F, Dipersio, JF, Westervelt, P, Ritz, J & Soiffer, RJ 2018, 'Effect of Antihuman T Lymphocyte Globulin on Immune Recovery after Myeloablative Allogeneic Stem Cell Transplantation with Matched Unrelated Donors: Analysis of Immune Reconstitution in a Double-Blind Randomized Controlled Trial', Biology of Blood and Marrow Transplantation, vol. 24, no. 11, pp. 2216-2223. https://doi.org/10.1016/j.bbmt.2018.07.002
V212 Protocol 001 Trial Team 2018, 'Inactivated varicella zoster vaccine in autologous haemopoietic stem-cell transplant recipients: an international, multicentre, randomised, double-blind, placebo-controlled trial', The Lancet, vol. 391, no. 10135, pp. 2116-2127. https://doi.org/10.1016/S0140-6736(18)30631-7
Wang, L, Jia, B, Claxton, D, Ehmann, WC, Rybka, W, Mineishi, S, Naik, S, Khawaja, MR, Sivik, J, Han, J, Hohl, R & Zheng, H 2018, 'VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML' OncoImmunology, vol. 7, no. 9, e1469594. https://doi.org/10.1080/2162402X.2018.1469594

2017

Zhu, L, Kong, Y, Zhang, J, Claxton, D, Ehmann, WC, Rybka, W, Palmisiano, ND, Wang, M, Jia, B, Bayerl, M, Schell, T, Hohl, R, Zeng, H & Zheng, H 2017, 'Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia', Journal of Hematology and Oncology, vol. 10, no. 1, 124. https://doi.org/10.1186/s13045-017-0486-z
Teye, EK, Sido, A, Xin, P, Finnberg, NK, Gokare, P, Imamura, Y, Salzberg, AC, Shimko, S, Bayerl, M, Ehmann, WC, Claxton, D, Rybka, W, Drabick, J, Wang, H-G, Abraham, T, El-Deiry, WS, Brodsky, RA, J.Hohl, R & Pu, J 2017, 'PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features' Oncotarget, vol. 8, no. 18, pp. 29887-29905. https://doi.org/10.18632/oncotarget.15136
Soiffer, RJ, Kim, HT, McGuirk, J, Horwitz, ME, Johnston, L, Patnaik, MM, Rybka, W, Artz, A, Porter, DL, Shea, TC, Boyer, MW, Maziarz, RT, Shaughnessy, PJ, Gergis, U, Safah, H, Reshef, R, Dipersio, JF, Stiff, PJ, Vusirikala, M, Szer, J, Holter, J, Levine, JD, Martin, PJ, Pidala, JA, Lewis, ID, Ho, VT, Alyea, EP, Ritz, J, Glavin, F, Westervelt, P, Jagasia, MH & Chen, YB 2017, 'Prospective, randomized, double-blind, phase III clinical trial of anti-T-lymphocyte globulin to assess impact on chronic graft-versus-host disease-free survival in patients undergoing HLA-matched unrelated myeloablative hematopoietic cell transplantation', Journal of Clinical Oncology, vol. 35, no. 36, pp. 4003-4011. https://doi.org/10.1200/JCO.2017.75.8177

2016

Santos, MA, Ehmann, WC & Rybka, W 2016, 'Keep Your Eyes Peeled: Chemosis and Proptosis from Relapsed Leukemia' American Journal of Medicine, vol. 129, no. 7, pp. e69-e70. https://doi.org/10.1016/j.amjmed.2016.01.040
Kong, Y, Zhu, L, Schell, T, Zhang, J, Claxton, D, Ehmann, WC, Rybka, W, George, M, Zeng, H & Zheng, H 2016, 'T-cell immunoglobulin and ITIM domain (TIGIT) associates with CD8+ T-cell exhaustion and poor clinical outcome in AML patients', Clinical Cancer Research, vol. 22, no. 12, pp. 3057-3066. https://doi.org/10.1158/1078-0432.CCR-15-2626

2015

Kong, Y, Zhang, J, Claxton, D, Ehmann, WC, Rybka, W, Zhu, L, Zeng, H, Schell, T & Zheng, H 2015, ' PD-1 hi TIM-3 + T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation ', Blood Cancer Journal, vol. 5, no. 7, e330. https://doi.org/10.1038/bcj.2015.58
Abbi, KKS, Rybka, W, Ehmann, WC & Claxton, D 2015, 'Phase I/II study of clofarabine, etoposide, and mitoxantrone in patients with refractory or relapsed acute leukemia' Clinical Lymphoma, Myeloma and Leukemia, vol. 15, no. 1, pp. 41-46. https://doi.org/10.1016/j.clml.2014.06.005

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)