Seema Naik, MD - Penn State Cancer Institute
Researcher Profile
Seema Naik, MD
Associate Professor, Department of Medicine
Division of Hematology and Oncology
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Bone Marrow Transplantation Team
Cancer Institute, Leukemia and Lymphoma Team
Cancer Institute, Leukemia and Lymphoma Team
Research Interests
- Transplants
- Burkitt Lymphoma
- Cell Transplantation
- Survival
- Bone Marrow
- Neoplasms
- Acute Myeloid Leukemia
- Quality of Life
- T-Lymphocytes
- Transplantation
- Hematopoietic Stem Cell Transplantation
- Tissue Donors
Clinical Trials
A Randomized, Open Label Phase 3 Study Evaluating Safety and Efficacy of Venetoclax in combination with Azacitidine after allogeneic Stem Cell Transplantation in Subjects with Acute Myeloid Leukemia (AML)(M19-063)
EAA173 Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM)
A Phase 2, Open-Label Trial to Evaluate Safety of Epcoritamab Monotherapy in Subjects with Relapsed or Refractory Diffuse Large B-Cell Lymphoma and Follicular Lymphoma Grade 1-3a when Administered in the Outpatient Setting
A Phase Ib/II Study of Venetoclax (ABT-199) in Combination with Liposomal Vincristine in Patients with Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
A Multi-Institutional Retrospective Study of Patient Characteristics, Treatment Patterns and Outcomes in Older Patients with Primary Central Nervous System Lymphoma
bcr-abl PCR response to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia in Stable Chronic Phase.
An Open-Label, Randomized, Multicenter, Phase Ib/II Trial Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) In Combination with Polatuzumab Vedotin in Patients with B-Cell Non-Hodgkin Lymphoma
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
Assessment of Allogeneic Hematopoietic Cell Transplantation in Medicare Beneficiaries with Multiple Myeloma: A Study to Develop Evidence of Effectiveness for the Centers for Medicare and Medicaid Services (CMS)
Recent Publications
2023
Potiaumpai, M, Schmitz, KH, Mineishi, S, Naik, S, Wirk, B, Rakszawski, K, Ehmann, WC, Claxton, D, Nickolich, M, Zemel, BS & Zheng, H 2023, 'IMPROVE-BMT: A protocol for a pilot randomised controlled trial of prehabilitation exercise for adult haematopoietic stem cell transplant recipients', BMJ open, vol. 13, no. 1, e066841. https://doi.org/10.1136/bmjopen-2022-066841
2022
Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2023, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology, vol. 102, no. 3, pp. 613-620. https://doi.org/10.1007/s00277-022-05077-2
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Phelan, R, Im, A, Hunter, RL, Inamoto, Y, Lupo-Stanghellini, MT, Rovo, A, Badawy, SM, Burns, L, Eissa, H, Murthy, HS, Prasad, P, Sharma, A, Suelzer, E, Agrawal, V, Aljurf, M, Baker, K, Basak, GW, Buchbinder, D, DeFilipp, Z, Grkovic, LD, Dias, A, Einsele, H, Eisenberg, ML, Epperla, N, Farhadfar, N, Flatau, A, Gale, RP, Greinix, H, Hamilton, BK, Hashmi, S, Hematti, P, Jamani, K, Maharaj, D, Murray, J, Naik, S, Nathan, S, Pavletic, S, Peric, Z, Pulanic, D, Ross, R, Salonia, A, Sanchez-Ortega, I, Savani, BN, Schechter, T, Shah, AJ, Smith, SM, Snowden, JA, Steinberg, A, Tremblay, D, Vij, SC, Walker, L, Wolff, D, Yared, JA, Schoemans, H & Tichelli, A 2022, 'Male-Specific Late Effects in Adult Hematopoietic Cell Transplantation Recipients: A Systematic Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation', Transplantation and Cellular Therapy, vol. 28, no. 6, pp. 335.e1-335.e17. https://doi.org/10.1016/j.jtct.2021.10.013
Phelan, R, Im, A, Hunter, RL, Inamoto, Y, Lupo-Stanghellini, MT, Rovo, A, Badawy, SM, Burns, L, Eissa, H, Murthy, HS, Prasad, P, Sharma, A, Suelzer, E, Agrawal, V, Aljurf, M, Baker, K, Basak, GW, Buchbinder, D, DeFilipp, Z, Grkovic, LD, Dias, A, Einsele, H, Eisenberg, ML, Epperla, N, Farhadfar, N, Flatau, A, Gale, RP, Greinix, H, Hamilton, BK, Hashmi, S, Hematti, P, Jamani, K, Maharaj, D, Murray, J, Naik, S, Nathan, S, Pavletic, S, Peric, Z, Pulanic, D, Ross, R, Salonia, A, Sanchez-Ortega, I, Savani, BN, Schechter, T, Shah, AJ, Smith, SM, Snowden, JA, Steinberg, A, Tremblay, D, Vij, SC, Walker, L, Wolff, D, Yared, JA, Schoemans, H & Tichelli, A 2022, 'Male-specific late effects in adult hematopoietic cell transplantation recipients: a systematic review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation', Bone Marrow Transplantation, vol. 57, no. 7, pp. 1150-1163. https://doi.org/10.1038/s41409-022-01591-z
Pizzola, CJ, Cioccio, J, Rakszawski, KL, Nickolich, M, Ehmann, WC, Rybka, WB, Wirk, B, Naik, S, Zheng, H, Silar, B, Shike, H, Zhou, S, Mineishi, S, Minagawa, K & Claxton, DF 2022, 'Non-myeloablative allogeneic stem cell transplant with fludarabine and reduced dose cyclophosphamide in acute myeloid leukemia for older adults with comorbidities', Bone Marrow Transplantation, vol. 57, no. 11, pp. 1743-1745. https://doi.org/10.1038/s41409-022-01821-4
Zhao, C, Bartock, M, Jia, B, Shah, N, Claxton, DF, Wirk, B, Rakszawski, KL, Nickolich, MS, Naik, SG, Rybka, WB, Ehmann, WCC, Hohl, RJ, Valentin, J, Bernas-Peterson, M, Gerber, EM, Zimmerman, M, Mierski, JA, Mineishi, S & Zheng, H 2022, 'Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant', Journal of Hematology and Oncology, vol. 15, no. 1, 64. https://doi.org/10.1186/s13045-022-01287-3
2021
The Burkitt Lymphoma International Prognostic Index Consortium 2021, 'Burkitt Lymphoma International Prognostic Index', Journal of Clinical Oncology, vol. 39, no. 10, pp. 1129-1138. https://doi.org/10.1200/JCO.20.03288
Evens, AM, Danilov, A, Jagadeesh, D, Sperling, A, Kim, SH, Vaca, R, Wei, C, Rector, D, Sundaram, S, Reddy, N, Lin, Y, Farooq, U, D'Angelo, C, Bond, DA, Berg, S, Churnetski, MC, Godara, A, Khan, N, Choi, YK, Yazdy, M, Rabinovich, E, Varma, G, Karmali, R, Mian, A, Savani, M, Burkart, M, Martin, P, Ren, A, Chauhan, A, Diefenbach, C, Straker-Edwards, A, Klein, AK, Blum, KA, Boughan, KM, Smith, SE, Haverkos, BM, Orellana-Noia, VM, Kenkre, VP, Zayac, A, Ramdial, J, Maliske, SM, Epperla, N, Venugopal, P, Feldman, TA, Smith, SD, Stadnik, A, David, KA, Naik, S, Lossos, IS, Lunning, MA, Caimi, P, Kamdar, M, Palmisiano, N, Bachanova, V, Portell, CA, Phillips, T, Olszewski, AJ & Alderuccio, JP 2021, 'Burkitt lymphoma in the modern era: Real-world outcomes and prognostication across 30 US cancer centers', Blood, vol. 137, no. 3, pp. 374-386. https://doi.org/10.1182/blood.2020006926
Alderuccio, JP, Olszewski, AJ, Evens, AM, Collins, GP, Danilov, AV, Bower, M, Jagadeesh, D, Zhu, C, Sperling, A, Kim, SH, Vaca, R, Wei, C, Sundaram, S, Reddy, N, Pria, AD, D'Angelo, C, Farooq, U, Bond, DA, Berg, S, Churnetski, MC, Godara, A, Khan, N, Choi, YK, Kassam, S, Yazdy, M, Rabinovich, E, Post, FA, Varma, G, Karmali, R, Burkart, M, Martin, P, Ren, A, Chauhan, A, Diefenbach, C, Straker-Edwards, A, Klein, A, Blum, KA, Boughan, KM, Mian, A, Haverkos, BM, Orellana-Noia, VM, Kenkre, VP, Zayac, A, Maliske, SM, Epperla, N, Caimi, P, Smith, SE, Kamdar, M, Venugopal, P, Feldman, TA, Rector, D, Smith, SD, Stadnik, A, Portell, CA, Lin, Y, Naik, S, Montoto, S, Lossos, IS & Cwynarski, K 2021, 'HIV-associated Burkitt lymphoma: Outcomes from a US-UK collaborative analysis', Blood Advances, vol. 5, no. 14, pp. 2852-2862. https://doi.org/10.1182/bloodadvances.2021004458
Shah, N, Rakszawski, K, Nickolich, M, Ehmann, C, Wirk, B, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Mackey, G, Greiner, R, Brown, V, Claxton, D, Mineishi, S & Minagawa, K 2021, 'Improved outcome in AML relapse after allogeneic transplant with high-intensity chemotherapy followed by 2nd allogeneic stem cell transplant or donor lymphocyte infusion', Annals of Hematology, vol. 100, no. 10, pp. 2585-2592. https://doi.org/10.1007/s00277-021-04616-7
Zayac, AS, Evens, AM, Danilov, A, Smith, SD, Jagadeesh, D, Leslie, LA, Wei, C, Kim, SH, Naik, S, Sundaram, S, Reddy, N, Farooq, U, Kenkre, VP, Epperla, N, Blum, KA, Khan, N, Singh, D, Alderuccio, JP, Godara, A, Yazdy, MS, Diefenbach, C, Rabinovich, E, Varma, G, Karmali, R, Shao, Y, Trabolsi, A, Burkart, M, Martin, P, Stettner, S, Chauhan, A, Choi, YK, Straker-Edwards, A, Klein, A, Churnetski, MC, Boughan, KM, Berg, S, Haverkos, BM, Orellana-Noia, VM, D'Angelo, C, Bond, DA, Maliske, SM, Vaca, R, Magarelli, G, Sperling, A, Gordon, MJ, David, KA, Savani, M, Caimi, P, Kamdar, M, Lunning, MA, Palmisiano, N, Venugopal, P, Portell, CA, Bachanova, V, Phillips, T, Lossos, IS & Olszewski, AJ 2021, 'Outcomes of Burkitt lymphoma with central nervous system involvement: Evidence from a large multicenter cohort study', Haematologica, vol. 106, no. 7, pp. 1932-1942. https://doi.org/10.3324/haematol.2020.270876
Gvozdjan, K, Casey, H, Mowery, C, Kumer, L, Fisher, C, Tyler, J, Bayerl, MG, Malysz, J, Naik, S, Rybka, W, Ehmann, C, Claxton, D, Mineishi, S, Baker, M, Hong, Z & Shike, H 2021, 'Unexpected Short-Tandem-Repeat Patterns in Post-Transplant Chimerism Testing: Investigation of 3 Cases with Help from Forensic Science', Laboratory Medicine, vol. 51, no. 6, pp. 635-641. https://doi.org/10.1093/LABMED/LMAA022
2020
Zheng, H, Mineishi, S, Claxton, D, Zhu, J, Zhao, C, Jia, B, Ehmann, WC, Rybka, WB, Naik, S, Songdej, N, Drabick, JJ & Hohl, RJ 2021, 'A phase I clinical trial of avelumab in combination with decitabine as first line treatment of unfit patients with acute myeloid leukemia', American Journal of Hematology, vol. 96, no. 2, pp. E46-E50. https://doi.org/10.1002/ajh.26043
2019
Kilari, D, D'Souza, A, Fraser, R, Qayed, M, Davila, O, Agrawal, V, Diaz, MA, Chhabra, S, Cerny, J, Copelan, E, Farhadfar, N, Freytes, CO, Gale, RP, Ganguly, S, Hildebrandt, GC, Holmberg, L, Kamble, RT, Kapoor, P, Lazarus, H, Lee, C, Murthy, HS, Naik, S, Nishihori, T, Saad, A, Savani, BN, Seo, S, Warwick, A, Wirk, B, Yared, JA, Nieto, Y & Hari, P 2019, 'Autologous Hematopoietic Stem Cell Transplantation for Male Germ Cell Tumors: Improved Outcomes Over 3 Decades', Biology of Blood and Marrow Transplantation, vol. 25, no. 6, pp. 1099-1106. https://doi.org/10.1016/j.bbmt.2019.02.015
Zhao, C, Jia, B, Wang, M, Schell, TD, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Naik, S, Songdej, N, Sivik, JM, Hohl, RJ, Zeng, H & Zheng, H 2020, 'Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML', British Journal of Haematology, vol. 188, no. 5, pp. 674-684. https://doi.org/10.1111/bjh.16228
Naik, S, Riches, M, Hari, P, Kim, S, Chen, M, Bachier, C, Shaughnessy, P, Hill, J, Ljungman, P, Battiwalla, M, Chhabra, S, Daly, A, Storek, J, Ustun, C, Diaz, MA, Cerny, J, Beitinjaneh, A, Yared, J, Brown, V, Page, K, Dahi, PB, Ganguly, S, Seo, S, Chao, N, Freytes, CO, Saad, A, Savani, BN, Woo Ahn, K, Boeckh, M, Heslop, HE, Lazarus, HM, Auletta, JJ & Kamble, RT 2019, 'Survival outcomes of allogeneic hematopoietic cell transplants with EBV-positive or EBV-negative post-transplant lymphoproliferative disorder, A CIBMTR study', Transplant Infectious Disease, vol. 21, no. 5, e13145. https://doi.org/10.1111/tid.13145