Researcher Profile

Researcher Profile

Seema Naik, MD

Seema Naik, MD

Associate Professor, Department of Medicine
Division of Hematology and Oncology
Disease Teams:
Bone Marrow Transplantation
Leukemia and Lymphoma
sun198@psu.edu

Research Interests

  • Transplants
  • Acute Myeloid Leukemia
  • Cell Transplantation
  • Bone Marrow
  • Hematopoietic Stem Cell Transplantation
  • Quality of Life
  • Lymphoproliferative Disorders
  • Proxy
  • Transplant Recipients
  • Burkitt Lymphoma
  • T-Lymphocytes
  • Survival

Clinical Trials

Effect of Omega-3 Fatty Acid, Eicosapentaenoic Acid, and its Metabolites in Combination with Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia in Stable Chronic Phase
bcr-abl PCR response to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia in Stable Chronic Phase.
Clofarabine followed by Fludarabine, Busulfan, Total-Body Irradiation and Hematopoietic Stem Cell Transplant with Post-Transplant Cyclophosphamide for Non-remission Acute Myeloid Leukemia
WT-1 monitoring for leukemia patients with allogenic transplant
A Phase Ib/II Study of Venetoclax (ABT-199) in Combination with Liposomal Vincristine in Patients with Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia
An Open-Label, Randomized, Multicenter, Phase Ib/II Trial Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) In Combination with Polatuzumab Vedotin in Patients with B-Cell Non-Hodgkin Lymphoma
Randomized Trial of Gilteritinib vs Midostaurin in FLT3 Mutated Acute Myeloid Leukemia (AML)
The Effects of a Prehabilitation Exercise Program in Adults Receiving a Hematopoietic Stem Cell Transplant
EA9161: A Randomized Phase III Study of the Addition of Venetoclax to Ibrutinib and Obinutuzumab versus Ibrutinib and Obinutuzumab in Untreated Younger Patients with Chronic Lymphocytic Leukemia (CLL)
Assessment of Allogeneic Hematopoietic Cell Transplantation in Medicare Beneficiaries with Multiple Myeloma: A Study to Develop Evidence of Effectiveness for the Centers for Medicare and Medicaid Services (CMS)
Burkitt Lymphoma: A Retrospective Review of Treatment and Outcomes
Phase II Study of Bendamustine and Rituximab plus Venetoclax in Untreated Mantle Cell Lymphoma over 60 Years of Age
Phase III study of daratumumab/rHuPH20 (NSC- 810307) + lenalidomide or lenalidomide as post-autologous stem cell transplant maintenance therapy in patients with multiple myeloma (MM) using minimal residual disease to direct therapy duration (DRAMMATIC Study)
A Randomized, Double blind, Placebo-controlled, Multi-center, Phase III Study of CD24Fc for Prevention of Acute Graft-versus-Host Disease Following Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation
A Multi-Institutional Retrospective Study of Patient Characteristics, Treatment Patterns and Outcomes in Older Patients with Primary Central Nervous System Lymphoma
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications

Recent Publications

2020

Zheng, H, Mineishi, S, Claxton, D, Zhu, J, Zhao, C, Jia, B, Ehmann, WC, Rybka, WB, Naik, S, Songdej, N, Drabick, JJ & Hohl, RJ 2020, 'A phase I clinical trial of avelumab in combination with decitabine as first line treatment of unfit patients with acute myeloid leukemia', American Journal of Hematology. https://doi.org/10.1002/ajh.26043

2019

Kilari, D, D'Souza, A, Fraser, R, Qayed, M, Davila, O, Agrawal, V, Diaz, MA, Chhabra, S, Cerny, J, Copelan, E, Farhadfar, N, Freytes, CO, Gale, RP, Ganguly, S, Hildebrandt, GC, Holmberg, L, Kamble, RT, Kapoor, P, Lazarus, H, Lee, C, Murthy, HS, Naik, S, Nishihori, T, Saad, A, Savani, BN, Seo, S, Warwick, A, Wirk, B, Yared, JA, Nieto, Y & Hari, P 2019, 'Autologous Hematopoietic Stem Cell Transplantation for Male Germ Cell Tumors: Improved Outcomes Over 3 Decades', Biology of Blood and Marrow Transplantation, vol. 25, no. 6, pp. 1099-1106. https://doi.org/10.1016/j.bbmt.2019.02.015
Zhao, C, Jia, B, Wang, M, Schell, TD, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Naik, S, Songdej, N, Sivik, JM, Hohl, RJ, Zeng, H & Zheng, H 2020, 'Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML', British Journal of Haematology, vol. 188, no. 5, pp. 674-684. https://doi.org/10.1111/bjh.16228
Naik, S, Riches, M, Hari, P, Kim, S, Chen, M, Bachier, C, Shaughnessy, P, Hill, J, Ljungman, P, Battiwalla, M, Chhabra, S, Daly, A, Storek, J, Ustun, C, Diaz, MA, Cerny, J, Beitinjaneh, A, Yared, J, Brown, V, Page, K, Dahi, PB, Ganguly, S, Seo, S, Chao, N, Freytes, CO, Saad, A, Savani, BN, Woo Ahn, K, Boeckh, M, Heslop, HE, Lazarus, HM, Auletta, JJ & Kamble, RT 2019, 'Survival outcomes of allogeneic hematopoietic cell transplants with EBV-positive or EBV-negative post-transplant lymphoproliferative disorder, A CIBMTR study', Transplant Infectious Disease, vol. 21, no. 5, e13145. https://doi.org/10.1111/tid.13145

2018

Naik, S 2018, Burkitt’s lymphoma: Etioloy, pathology, prognosis and treatment. in Advances in Health and Disease. vol. 4, Nova Science Publishers, Inc., pp. 173-194.
Rakszawski, K, Miki, K, Claxton, D, Wagner Jr., H, Shike, H, Mineishi, S & Naik, S 2018, 'Clofarabine followed by haploidentical stem cell transplant using fludarabine, busulfan, and total-body irradiation with post-transplant cyclophosphamide in non-remission AML', International journal of hematology, vol. 108, no. 3, pp. 348-350. https://doi.org/10.1007/s12185-018-2431-5
Buchbinder, D, Kelly, DL, Duarte, RF, Auletta, JJ, Bhatt, N, Byrne, M, Defilipp, Z, Gabriel, M, Mahindra, A, Norkin, M, Schoemans, H, Shah, AJ, Ahmed, I, Atsuta, Y, Basak, GW, Beattie, S, Bhella, S, Bredeson, C, Bunin, N, Dalal, J, Daly, A, Gajewski, J, Gale, RP, Galvin, J, Hamadani, M, Hayashi, RJ, Adekola, K, Law, J, Lee, CJ, Liesveld, J, Malone, AK, Nagler, A, Naik, S, Nishihori, T, Parsons, SK, Scherwath, A, Schofield, HL, Soiffer, R, Szer, J, Twist, I, Warwick, AB, Wirk, BM, Yi, J, Battiwalla, M, Flowers, MDE, Savani, B & Shaw, BE 2018, 'Neurocognitive dysfunction in hematopoietic cell transplant recipients: Expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT', Bone Marrow Transplantation, vol. 53, no. 5, pp. 535-555. https://doi.org/10.1038/s41409-017-0055-7
Wang, L, Jia, B, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Naik, S, Khawaja, MR, Sivik, J, Han, J, Hohl, RJ & Zheng, H 2018, 'VISTA is highly expressed on MDSCs and mediates an inhibition of T cell response in patients with AML', OncoImmunology, vol. 7, no. 9, e1469594. https://doi.org/10.1080/2162402X.2018.1469594

2017

Kelly, DL, Buchbinder, D, Duarte, RF, Auletta, JJ, Bhatt, N, Byrne, M, DeFilipp, Z, Gabriel, M, Mahindra, A, Norkin, M, Schoemans, H, Shah, AJ, Ahmed, I, Atsuta, Y, Basak, GW, Beattie, S, Bhella, S, Bredeson, C, Bunin, N, Dalal, J, Daly, A, Gajewski, J, Gale, RP, Galvin, J, Hamadani, M, Hayashi, RJ, Adekola, K, Law, J, Lee, CJ, Liesveld, J, Malone, AK, Nagler, A, Naik, S, Nishihori, T, Parsons, SK, Scherwath, A, Schofield, HL, Soiffer, R, Szer, J, Twist, I, Warwick, A, Wirk, BM, Yi, J, Battiwalla, M, Flowers, ME, Savani, B & Shaw, BE 2018, 'Neurocognitive Dysfunction in Hematopoietic Cell Transplant Recipients: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Complications and Quality of Life Working Party of the European Society for Blood and Marrow Transplantation', Biology of Blood and Marrow Transplantation, vol. 24, no. 2, pp. 228-241. https://doi.org/10.1016/j.bbmt.2017.09.004

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)