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Researcher Profile

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Seema Naik, MD

Seema Naik, MD

Associate Professor, Department of Medicine
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Bone Marrow Transplantation Team
Cancer Institute, Leukemia and Lymphoma Team
SUN198@psu.edu

Research Interests

  • Transplants
  • Burkitt Lymphoma
  • Cell Transplantation
  • Survival
  • Bone Marrow
  • Neoplasms
  • Acute Myeloid Leukemia
  • Quality of Life
  • T-Lymphocytes
  • Transplantation
  • Hematopoietic Stem Cell Transplantation
  • Tissue Donors

Clinical Trials

EAA173 Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM)
A Phase 2, Open-Label Trial to Evaluate Safety of Epcoritamab Monotherapy in Subjects with Relapsed or Refractory Diffuse Large B-Cell Lymphoma and Classic Follicular Lymphoma (Previously Grade 1-3a) when Administered in the Outpatient Setting
Phase III study of daratumumab/rHuPH20 (NSC- 810307) + lenalidomide or lenalidomide as post-autologous stem cell transplant maintenance therapy in patients with multiple myeloma (MM) using minimal residual disease to direct therapy duration (DRAMMATIC Study)
A Single-Arm, Open-Label Pharmacokinetic, Safety, and Efficacy Study of ASTX727 in Combination with Venetoclax in Adult Patients with Acute Myeloid Leukemia
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
A Phase 3 Randomized, Open-Label, Multicenter Study Evaluating the Efficacy of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Subjects with Relapsed/Refractory Follicular Lymphoma
A Multi-Institutional Retrospective Study of Patient Characteristics, Treatment Patterns and Outcomes in Older Patients with Primary Central Nervous System Lymphoma
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
Assessment of Allogeneic Hematopoietic Cell Transplantation in Medicare Beneficiaries with Multiple Myeloma: A Study to Develop Evidence of Effectiveness for the Centers for Medicare and Medicaid Services (CMS)

Recent Publications

2024

Naik, S, Rakszawski, K, Zheng, H, Claxton, D, Minagawa, K & Mineishi, S 2024, 'Clofarabine Preconditioning followed by Allogeneic Transplant Using TBI and Post-Transplant Cyclophosphamide for Relapsed Refractory Leukemia', International journal of molecular sciences, vol. 25, no. 2, 957. https://doi.org/10.3390/ijms25020957
Guare, EG, Hale, CM, Sivik, J, Lehman, E, Inoue, Y, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Claxton, D, Rybka, W, Hohl, R, Mineishi, S, Minagawa, K & Paules, CI 2024, 'The addition of doxycycline to fluoroquinolones for bacterial prophylaxis in autologous stem cell transplantation for multiple myeloma', Transplant Infectious Disease. https://doi.org/10.1111/tid.14241

2023

Zhou, H, Jia, B, Annageldiyev, C, Minagawa, K, Zhao, C, Mineishi, S, Ehmann, WC, Naik, SG, Cioccio, J, Wirk, B, Songdej, N, Rakszawski, KL, Nickolich, MS, Shen, J & Zheng, H 2023, 'CD26lowPD-1+ CD8 T cells are terminally exhausted and associated with leukemia progression in acute myeloid leukemia', Frontiers in immunology, vol. 14, 1169144. https://doi.org/10.3389/fimmu.2023.1169144
Agrawal, P, David, KA, Chen, Z, Sundaram, S, Kim, SH, Vaca, R, Lin, Y, Singer, S, Malecek, MK, Carter, J, Zayac, A, Kim, MS, Reddy, N, Ney, D, Habib, A, Strouse, C, Graber, J, Bachanova, V, Salman, S, Vendiola, JA, Hossain, N, Tsang, M, Major, A, Gandhi, MK, Keane, C, Bond, DA, Folstad, M, Chang, J, Mier-Hicks, A, Torka, P, Rajakumar, P, Venugopal, P, Berg, S, Glantz, M, Goldlust, SA, Matnani, R, Kumar, P, Ollila, TA, Cai, J, Spurgeon, SE, Sieg, AG, Cleveland, J, Epperla, N, Karmali, R, Naik, S, Smith, SM, Rubenstein, JL, Kahl, BS, Chadburn, A, Evens, AM & Martin, P 2023, 'EBV-positive PCNSL in older patients: incidence, characteristics, tumor pathology, and outcomes across a large multicenter cohort', Leukemia and Lymphoma, vol. 64, no. 5, pp. 1026-1034. https://doi.org/10.1080/10428194.2023.2191152
Zayac, AS, Landsburg, DJ, Hughes, ME, Bock, AM, Nowakowski, GS, Ayers, EC, Girton, M, Hu, M, Beckman, AK, Li, S, Medeiros, LJ, Chang, JE, Stepanovic, A, Kurt, H, Sandoval-Sus, J, Ansari-Lari, MA, Kothari, SK, Kress, A, Xu, ML, Torka, P, Sundaram, S, Smith, SD, Naresh, KN, Karimi, YH, Epperla, N, Bond, DA, Farooq, U, Saad, M, Evens, AM, Pandya, K, Naik, SG, Kamdar, M, Haverkos, B, Karmali, R, Oh, TS, Vose, JM, Nutsch, H, Rubinstein, PG, Chaudhry, A & Olszewski, AJ 2023, 'High-grade B-cell lymphoma, not otherwise specified: a multi-institutional retrospective study', Blood Advances, vol. 7, no. 21, pp. 6381-6394. https://doi.org/10.1182/bloodadvances.2023009731
Potiaumpai, M, Schmitz, KH, Mineishi, S, Naik, S, Wirk, B, Rakszawski, K, Ehmann, WC, Claxton, D, Nickolich, M, Zemel, BS & Zheng, H 2023, 'IMPROVE-BMT: A protocol for a pilot randomised controlled trial of prehabilitation exercise for adult haematopoietic stem cell transplant recipients', BMJ open, vol. 13, no. 1, e066841. https://doi.org/10.1136/bmjopen-2022-066841
Budde, LE, Olszewski, AJ, Assouline, S, Lossos, IS, Diefenbach, C, Kamdar, M, Ghosh, N, Modi, D, Sabry, W, Naik, S, Mehta, A, Nakhoda, SK, Smith, SD, Dorritie, K, Jia, T, Pham, S, Huw, LY, Jing, J, Wu, H, Ead, WS, To, I, Batlevi, CL, Wei, MC & Chavez, JC 2024, 'Mosunetuzumab with polatuzumab vedotin in relapsed or refractory aggressive large B cell lymphoma: a phase 1b/2 trial', Nature Medicine, vol. 30, no. 1, pp. 229-239. https://doi.org/10.1038/s41591-023-02726-5
David, KA, Sundaram, S, Kim, SH, Vaca, R, Lin, Y, Singer, S, Malecek, MK, Carter, J, Zayac, A, Kim, MS, Reddy, N, Ney, D, Habib, A, Strouse, C, Graber, J, Bachanova, V, Salman, S, Vendiola, JA, Hossain, N, Tsang, M, Major, A, Bond, DA, Agrawal, P, Mier-Hicks, A, Torka, P, Rajakumar, P, Venugopal, P, Berg, S, Glantz, M, Goldlust, SA, Folstad, M, Kumar, P, Ollila, TA, Cai, J, Spurgeon, S, Sieg, A, Cleveland, J, Chang, J, Epperla, N, Karmali, R, Naik, S, Martin, P, Smith, SM, Rubenstein, J, Kahl, B & Evens, AM 2023, 'Older patients with primary central nervous system lymphoma: Survival and prognostication across 20 U.S. cancer centers', American Journal of Hematology, vol. 98, no. 6, pp. 900-912. https://doi.org/10.1002/ajh.26919
McKenna, M, Epperla, N, Ghobadi, A, Liu, J, Lazaryan, A, Ibrahim, U, Jacobson, CA, Naik, SG, Nastoupil, L, Chowdhury, SM, Voorhees, TJ, Jacobs, MT, Farooq, U, Osman, K, Olszewski, AJ, Ahmed, S & Evens, AM 2023, 'Real-world evidence of the safety and survival with CD19 CAR-T cell therapy for relapsed/refractory solid organ transplant-related PTLD', British Journal of Haematology, vol. 202, no. 2, pp. 248-255. https://doi.org/10.1111/bjh.18828

2022

Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2023, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology, vol. 102, no. 3, pp. 613-620. https://doi.org/10.1007/s00277-022-05077-2
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Phelan, R, Im, A, Hunter, RL, Inamoto, Y, Lupo-Stanghellini, MT, Rovo, A, Badawy, SM, Burns, L, Eissa, H, Murthy, HS, Prasad, P, Sharma, A, Suelzer, E, Agrawal, V, Aljurf, M, Baker, K, Basak, GW, Buchbinder, D, DeFilipp, Z, Grkovic, LD, Dias, A, Einsele, H, Eisenberg, ML, Epperla, N, Farhadfar, N, Flatau, A, Gale, RP, Greinix, H, Hamilton, BK, Hashmi, S, Hematti, P, Jamani, K, Maharaj, D, Murray, J, Naik, S, Nathan, S, Pavletic, S, Peric, Z, Pulanic, D, Ross, R, Salonia, A, Sanchez-Ortega, I, Savani, BN, Schechter, T, Shah, AJ, Smith, SM, Snowden, JA, Steinberg, A, Tremblay, D, Vij, SC, Walker, L, Wolff, D, Yared, JA, Schoemans, H & Tichelli, A 2022, 'Male-Specific Late Effects in Adult Hematopoietic Cell Transplantation Recipients: A Systematic Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation', Transplantation and Cellular Therapy, vol. 28, no. 6, pp. 335.e1-335.e17. https://doi.org/10.1016/j.jtct.2021.10.013
Phelan, R, Im, A, Hunter, RL, Inamoto, Y, Lupo-Stanghellini, MT, Rovo, A, Badawy, SM, Burns, L, Eissa, H, Murthy, HS, Prasad, P, Sharma, A, Suelzer, E, Agrawal, V, Aljurf, M, Baker, K, Basak, GW, Buchbinder, D, DeFilipp, Z, Grkovic, LD, Dias, A, Einsele, H, Eisenberg, ML, Epperla, N, Farhadfar, N, Flatau, A, Gale, RP, Greinix, H, Hamilton, BK, Hashmi, S, Hematti, P, Jamani, K, Maharaj, D, Murray, J, Naik, S, Nathan, S, Pavletic, S, Peric, Z, Pulanic, D, Ross, R, Salonia, A, Sanchez-Ortega, I, Savani, BN, Schechter, T, Shah, AJ, Smith, SM, Snowden, JA, Steinberg, A, Tremblay, D, Vij, SC, Walker, L, Wolff, D, Yared, JA, Schoemans, H & Tichelli, A 2022, 'Male-specific late effects in adult hematopoietic cell transplantation recipients: a systematic review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation', Bone Marrow Transplantation, vol. 57, no. 7, pp. 1150-1163. https://doi.org/10.1038/s41409-022-01591-z
Pizzola, CJ, Cioccio, J, Rakszawski, KL, Nickolich, M, Ehmann, WC, Rybka, WB, Wirk, B, Naik, S, Zheng, H, Silar, B, Shike, H, Zhou, S, Mineishi, S, Minagawa, K & Claxton, DF 2022, 'Non-myeloablative allogeneic stem cell transplant with fludarabine and reduced dose cyclophosphamide in acute myeloid leukemia for older adults with comorbidities', Bone Marrow Transplantation, vol. 57, no. 11, pp. 1743-1745. https://doi.org/10.1038/s41409-022-01821-4
Zhao, C, Bartock, M, Jia, B, Shah, N, Claxton, DF, Wirk, B, Rakszawski, KL, Nickolich, MS, Naik, SG, Rybka, WB, Ehmann, WCC, Hohl, RJ, Valentin, J, Bernas-Peterson, M, Gerber, EM, Zimmerman, M, Mierski, JA, Mineishi, S & Zheng, H 2022, 'Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant', Journal of Hematology and Oncology, vol. 15, no. 1, 64. https://doi.org/10.1186/s13045-022-01287-3

2021

The Burkitt Lymphoma International Prognostic Index Consortium 2021, 'Burkitt Lymphoma International Prognostic Index', Journal of Clinical Oncology, vol. 39, no. 10, pp. 1129-1138. https://doi.org/10.1200/JCO.20.03288
Evens, AM, Danilov, A, Jagadeesh, D, Sperling, A, Kim, SH, Vaca, R, Wei, C, Rector, D, Sundaram, S, Reddy, N, Lin, Y, Farooq, U, D'Angelo, C, Bond, DA, Berg, S, Churnetski, MC, Godara, A, Khan, N, Choi, YK, Yazdy, M, Rabinovich, E, Varma, G, Karmali, R, Mian, A, Savani, M, Burkart, M, Martin, P, Ren, A, Chauhan, A, Diefenbach, C, Straker-Edwards, A, Klein, AK, Blum, KA, Boughan, KM, Smith, SE, Haverkos, BM, Orellana-Noia, VM, Kenkre, VP, Zayac, A, Ramdial, J, Maliske, SM, Epperla, N, Venugopal, P, Feldman, TA, Smith, SD, Stadnik, A, David, KA, Naik, S, Lossos, IS, Lunning, MA, Caimi, P, Kamdar, M, Palmisiano, N, Bachanova, V, Portell, CA, Phillips, T, Olszewski, AJ & Alderuccio, JP 2021, 'Burkitt lymphoma in the modern era: Real-world outcomes and prognostication across 30 US cancer centers', Blood, vol. 137, no. 3, pp. 374-386. https://doi.org/10.1182/blood.2020006926
Alderuccio, JP, Olszewski, AJ, Evens, AM, Collins, GP, Danilov, AV, Bower, M, Jagadeesh, D, Zhu, C, Sperling, A, Kim, SH, Vaca, R, Wei, C, Sundaram, S, Reddy, N, Pria, AD, D'Angelo, C, Farooq, U, Bond, DA, Berg, S, Churnetski, MC, Godara, A, Khan, N, Choi, YK, Kassam, S, Yazdy, M, Rabinovich, E, Post, FA, Varma, G, Karmali, R, Burkart, M, Martin, P, Ren, A, Chauhan, A, Diefenbach, C, Straker-Edwards, A, Klein, A, Blum, KA, Boughan, KM, Mian, A, Haverkos, BM, Orellana-Noia, VM, Kenkre, VP, Zayac, A, Maliske, SM, Epperla, N, Caimi, P, Smith, SE, Kamdar, M, Venugopal, P, Feldman, TA, Rector, D, Smith, SD, Stadnik, A, Portell, CA, Lin, Y, Naik, S, Montoto, S, Lossos, IS & Cwynarski, K 2021, 'HIV-associated Burkitt lymphoma: Outcomes from a US-UK collaborative analysis', Blood Advances, vol. 5, no. 14, pp. 2852-2862. https://doi.org/10.1182/bloodadvances.2021004458
Shah, N, Rakszawski, K, Nickolich, M, Ehmann, C, Wirk, B, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Mackey, G, Greiner, R, Brown, V, Claxton, D, Mineishi, S & Minagawa, K 2021, 'Improved outcome in AML relapse after allogeneic transplant with high-intensity chemotherapy followed by 2nd allogeneic stem cell transplant or donor lymphocyte infusion', Annals of Hematology, vol. 100, no. 10, pp. 2585-2592. https://doi.org/10.1007/s00277-021-04616-7
Zayac, AS, Evens, AM, Danilov, A, Smith, SD, Jagadeesh, D, Leslie, LA, Wei, C, Kim, SH, Naik, S, Sundaram, S, Reddy, N, Farooq, U, Kenkre, VP, Epperla, N, Blum, KA, Khan, N, Singh, D, Alderuccio, JP, Godara, A, Yazdy, MS, Diefenbach, C, Rabinovich, E, Varma, G, Karmali, R, Shao, Y, Trabolsi, A, Burkart, M, Martin, P, Stettner, S, Chauhan, A, Choi, YK, Straker-Edwards, A, Klein, A, Churnetski, MC, Boughan, KM, Berg, S, Haverkos, BM, Orellana-Noia, VM, D'Angelo, C, Bond, DA, Maliske, SM, Vaca, R, Magarelli, G, Sperling, A, Gordon, MJ, David, KA, Savani, M, Caimi, P, Kamdar, M, Lunning, MA, Palmisiano, N, Venugopal, P, Portell, CA, Bachanova, V, Phillips, T, Lossos, IS & Olszewski, AJ 2021, 'Outcomes of Burkitt lymphoma with central nervous system involvement: Evidence from a large multicenter cohort study', Haematologica, vol. 106, no. 7, pp. 1932-1942. https://doi.org/10.3324/haematol.2020.270876
Gvozdjan, K, Casey, H, Mowery, C, Kumer, L, Fisher, C, Tyler, J, Bayerl, MG, Malysz, J, Naik, S, Rybka, W, Ehmann, C, Claxton, D, Mineishi, S, Baker, M, Hong, Z & Shike, H 2021, 'Unexpected Short-Tandem-Repeat Patterns in Post-Transplant Chimerism Testing: Investigation of 3 Cases with Help from Forensic Science', Laboratory Medicine, vol. 51, no. 6, pp. 635-641. https://doi.org/10.1093/LABMED/LMAA022

2020

Zheng, H, Mineishi, S, Claxton, D, Zhu, J, Zhao, C, Jia, B, Ehmann, WC, Rybka, WB, Naik, S, Songdej, N, Drabick, JJ & Hohl, RJ 2021, 'A phase I clinical trial of avelumab in combination with decitabine as first line treatment of unfit patients with acute myeloid leukemia', American Journal of Hematology, vol. 96, no. 2, pp. E46-E50. https://doi.org/10.1002/ajh.26043