Brain Cancer Research

Brain Cancer Research

Research into brain cancer at Penn State Cancer Institute is conducted by the central nervous system cancer team. See current clinical trials and members of that team here.

Clinical Trials

A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens including Rare Pediatric Tumors.
Protocol for the Enrollment on the Official COG Registry, the Childhood Cancer Research Network (CCRN)
A COG Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens
Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1-21 years
Umbrella Long-term Follow-up Protocol
Neuropsychological, Social, Emotional, and Behavioral Outcomes in Children with Cancer
An Open-Label, Single-Arm, Phase II Study of Pertuzumab with High-Dose Trastuzumab for the Treatment of Central Nervous System Progression Post-Radiotherapy in Patients with HER2-Positive Metastatic Breast Cancer (PATRICIA)
A Phase III randomized double-blind, controlled study of ICT-107 with maintenance temozolomide (TMZ) in newly diagnosed glioblastoma following resection and concomitant TMZ chemoradiotherapy
NeMeRe, a Multi-Institutional Retrospective and Prospective Registry of Neoplastic Meningitis in Adults
A Phase 3, Randomized, Adaptive Study Comparing the Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients Undergoing Hematopoietic Stem Cell Transplant
Phase 1B, Multicenter, Open-Label Study of Marizomib Combined with Temozolomide and Radiotherapy in Patients with Newly Diagnosed WHO Grade IV Malignant Glioma
Headstart 4 - Newly Diagnosed Children (Less than 10 years old) with Medulloblastoma and OtherCentral Nervous System Embryonal Tumors
LEAHRN (Late Effects After High-Risk Neuroblastoma) Study
A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-RiskWNT-Driven Medulloblastoma Patients
Children's Lives Include Moments of Bravery (CLIMB)
TRPM2 Expression in Neuroblastoma and the Importance of Different Isoforms in Tumor Growth and Response to Chemotherapy
A Phase II Trial of Nifurtimox for Refractory or Relapsed Neuroblastoma or Medulloblastoma.
Length of Life versus Quality of Life in Patients with Glioblastoma: What Patients, Caregivers, and Providers Value; and Whose Wishes are Honored.
Utilizing Response-and Biology-Based Risk Factors to Guide Therapy in Patients with Non-High-Risk Neuroblastoma
A Pilot Study Using Molecular Guided Therapy with Induction Chemotherapy Followed by Maintenance with DFMO for Subjects with Newly Diagnosed High-Risk Neuroblastoma
A Phase I/II, Multicenter, Open-Label, Dose Escalation Study of the Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Patients with Previously Treated Solid Tumors
The Project: Every Child Protocol: A Registry, Eligibility Screening, Biology and Outcome Study
A Randomized, Placebo Controlled Phase 2b/3 Study of ABT-414 With Concurrent Chemoradiation and Adjuvant Temozolomide in Subjects With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification (Intellance 1)
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.

Disease Team Members

First Name Last Name Title Role
Dawit Aregawi, MD Dawit Aregawi MD View Profile
Ayodele Ayoola, MD Ayodele Ayoola MD View Profile
Joseph Drabick, MD, FACP Joseph Drabick MD, FACP View Profile
Matthew Evans, MD Matthew Evans MD View Profile
Elana Farace, PhD, MA Elana Farace PhD, MA View Profile
Michael Glantz, MD, PhD Michael Glantz MD, PhD View Profile
Kimberly Harbaugh, MD Kimberly Harbaugh MD View Profile
Robert Harbaugh, MD, FAANS, FACS, FAHA Robert Harbaugh MD, FAANS, FACS, FAHA View Profile
Kenneth Hill Jr., MD Kenneth Hill Jr. MD View Profile
Heath Mackley, MD, FACRO Heath Mackley MD, FACRO View Profile
James McInerney, MD James McInerney MD View Profile
G. Timothy Reiter, MD G. Timothy Reiter MD View Profile
Elias Rizk, MD, MSc Elias Rizk MD, MSc View Profile
Jennifer Rosenberg, MD Jennifer Rosenberg MD View Profile
Marc Rovito, MD Marc Rovito MD View Profile
Michael Sather, MD Michael Sather MD View Profile
Leonard Tuanquin, MD Leonard Tuanquin MD View Profile
Henry Wagner Jr., MD Henry Wagner Jr. MD View Profile
Brad Zacharia, MD, MS Brad Zacharia MD, MS View Profile
Research into brain cancer at Penn State Cancer Institute is conducted by the central nervous system cancer team. See current clinical trials and members of that team here.
A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens including Rare Pediatric Tumors.
Protocol for the Enrollment on the Official COG Registry, the Childhood Cancer Research Network (CCRN)
A COG Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens
Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1-21 years
Umbrella Long-term Follow-up Protocol
Neuropsychological, Social, Emotional, and Behavioral Outcomes in Children with Cancer
An Open-Label, Single-Arm, Phase II Study of Pertuzumab with High-Dose Trastuzumab for the Treatment of Central Nervous System Progression Post-Radiotherapy in Patients with HER2-Positive Metastatic Breast Cancer (PATRICIA)
A Phase III randomized double-blind, controlled study of ICT-107 with maintenance temozolomide (TMZ) in newly diagnosed glioblastoma following resection and concomitant TMZ chemoradiotherapy
NeMeRe, a Multi-Institutional Retrospective and Prospective Registry of Neoplastic Meningitis in Adults
A Phase 3, Randomized, Adaptive Study Comparing the Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients Undergoing Hematopoietic Stem Cell Transplant
Phase 1B, Multicenter, Open-Label Study of Marizomib Combined with Temozolomide and Radiotherapy in Patients with Newly Diagnosed WHO Grade IV Malignant Glioma
Headstart 4 - Newly Diagnosed Children (Less than 10 years old) with Medulloblastoma and OtherCentral Nervous System Embryonal Tumors
LEAHRN (Late Effects After High-Risk Neuroblastoma) Study
A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-RiskWNT-Driven Medulloblastoma Patients
Children's Lives Include Moments of Bravery (CLIMB)
TRPM2 Expression in Neuroblastoma and the Importance of Different Isoforms in Tumor Growth and Response to Chemotherapy
A Phase II Trial of Nifurtimox for Refractory or Relapsed Neuroblastoma or Medulloblastoma.
Length of Life versus Quality of Life in Patients with Glioblastoma: What Patients, Caregivers, and Providers Value; and Whose Wishes are Honored.
Utilizing Response-and Biology-Based Risk Factors to Guide Therapy in Patients with Non-High-Risk Neuroblastoma
A Pilot Study Using Molecular Guided Therapy with Induction Chemotherapy Followed by Maintenance with DFMO for Subjects with Newly Diagnosed High-Risk Neuroblastoma
A Phase I/II, Multicenter, Open-Label, Dose Escalation Study of the Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Patients with Previously Treated Solid Tumors
The Project: Every Child Protocol: A Registry, Eligibility Screening, Biology and Outcome Study
A Randomized, Placebo Controlled Phase 2b/3 Study of ABT-414 With Concurrent Chemoradiation and Adjuvant Temozolomide in Subjects With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification (Intellance 1)
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.
First Name Last Name Title Role
Dawit Aregawi, MD Dawit Aregawi MD View Profile
Ayodele Ayoola, MD Ayodele Ayoola MD View Profile
Joseph Drabick, MD, FACP Joseph Drabick MD, FACP View Profile
Matthew Evans, MD Matthew Evans MD View Profile
Elana Farace, PhD, MA Elana Farace PhD, MA View Profile
Michael Glantz, MD, PhD Michael Glantz MD, PhD View Profile
Kimberly Harbaugh, MD Kimberly Harbaugh MD View Profile
Robert Harbaugh, MD, FAANS, FACS, FAHA Robert Harbaugh MD, FAANS, FACS, FAHA View Profile
Kenneth Hill Jr., MD Kenneth Hill Jr. MD View Profile
Heath Mackley, MD, FACRO Heath Mackley MD, FACRO View Profile
James McInerney, MD James McInerney MD View Profile
G. Timothy Reiter, MD G. Timothy Reiter MD View Profile
Elias Rizk, MD, MSc Elias Rizk MD, MSc View Profile
Jennifer Rosenberg, MD Jennifer Rosenberg MD View Profile
Marc Rovito, MD Marc Rovito MD View Profile
Michael Sather, MD Michael Sather MD View Profile
Leonard Tuanquin, MD Leonard Tuanquin MD View Profile
Henry Wagner Jr., MD Henry Wagner Jr. MD View Profile
Brad Zacharia, MD, MS Brad Zacharia MD, MS View Profile

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)