David Claxton, MD - Penn State Cancer Institute
Researcher Profile
David Claxton, MD
Professor, Department of Medicine
Division of Hematology and Oncology
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Immunotherapy Team
Cancer Institute, Leukemia and Lymphoma Team
Cancer Institute, Leukemia and Lymphoma Team
Clinical Trials
Blood and Bone Marrow Collection from Patients with Hematological Malignancies for Study of Anti-Tumor Immunity
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
T-Cell Exhaustion in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.
Biologic Studies of Experimental Anti-Cancer Therapeutics in Human Leukemia Cells
Assessment of Allogeneic Hematopoietic Cell Transplantation in Medicare Beneficiaries with Multiple Myeloma: A Study to Develop Evidence of Effectiveness for the Centers for Medicare and Medicaid Services (CMS)
Recent Publications
2025
Hamamoto, K, Zhu, G, Lai, Q, Lesperance, J, Luo, H, Li, Y, Nigam, N, Sharma, A, Yang, FC, Claxton, D, Qiu, Y, Aplan, PD, Xu, M & Huang, S 2025, 'HoxBlinc lncRNA reprograms CTCF-independent TADs to drive leukemic transcription and HSC dysregulation in NUP98-rearranged leukemia', Journal of Clinical Investigation, vol. 135, no. 7, e184743. https://doi.org/10.1172/JCI184743
2024
Pu, JJ, Berger, KN, Zheng, C, Do, N, Claxton, DF, Ehmann, WC, Drabick, JJ, Li, H, Loughran, TP & Epner, EM 2024, 'A phase I study using bortezomib (Velcade), cladribine, and rituximab in treating patients over 50 years old with mantle cell lymphoma', Frontiers in Oncology, vol. 14, 1449401. https://doi.org/10.3389/fonc.2024.1449401
Paudel, BB, Tan, SF, Fox, TE, Ung, J, Golla, U, Shaw, JJP, Dunton, W, Lee, I, Fares, WA, Patel, S, Sharma, A, Viny, AD, Barth, BM, Tallman, MS, Cabot, M, Garrett-Bakelman, FE, Levine, RL, Kester, M, Feith, DJ, Claxton, D, Janes, KA & Loughran, TP 2024, 'Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes', Blood Advances, vol. 8, no. 5, pp. 1137-1142. https://doi.org/10.1182/bloodadvances.2023010535
Brow, D, Shike, H, Kendrick, J, Pettersson, L, Mineishi, S, Claxton, DF, Wirk, B, Cioccio, J, Greiner, RJ, Viswanatha, D, Kharfan-Dabaja, MA, Li, Z, Tyler, J & Elrefaei, M 2024, 'Assessment of chimerism by next generation sequencing: A comparison to STR/qPCR methods', Human Immunology, vol. 85, no. 3, 110794. https://doi.org/10.1016/j.humimm.2024.110794
Naik, S, Rakszawski, K, Zheng, H, Claxton, D, Minagawa, K & Mineishi, S 2024, 'Clofarabine Preconditioning followed by Allogeneic Transplant Using TBI and Post-Transplant Cyclophosphamide for Relapsed Refractory Leukemia', International journal of molecular sciences, vol. 25, no. 2, 957. https://doi.org/10.3390/ijms25020957
Zhang, A, Macecevic, S, Thomas, D, Allen, J, Mandley, S, Kawczak, P, Jurcago, R, Tyler, J, Casey, H, Bosler, D, Sobecks, R, Hamilton, B, Sauter, C, Mineishi, S, Claxton, D & Shike, H 2024, 'Engraftment and Measurable Residual Disease Monitoring after Hematopoietic Stem Cell Transplantation: Comparison of Two Chimerism Test Strategies, Next-Generation Sequencing versus a Combination of Short-Tandem Repeats and Quantitative PCR', Journal of Molecular Diagnostics, vol. 26, no. 4, pp. 233-244. https://doi.org/10.1016/j.jmoldx.2024.01.007
Golla, U, Patel, S, Shah, N, Talamo, S, Bhalodia, R, Claxton, D, Dovat, S & Sharma, A 2024, 'From Deworming to Cancer Therapy: Benzimidazoles in Hematological Malignancies', Cancers, vol. 16, no. 20, 3454. https://doi.org/10.3390/cancers16203454
Zulch, E, Inoue, Y, Cioccio, J, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Rybka, W, Ehmann, C, Sivik, J, Mierski, J, Silar, B, Vajdic, C, Greiner, R, Brown, V, Hohl, R, Claxton, D, Shike, H, Paules, CI, Mineishi, S & Minagawa, K 2024, 'Impact of post-transplant cyclophosphamide and splenomegaly on primary graft failure and multi-lineage cytopenia after allogeneic hematopoietic cell transplantation', Leukemia Research, vol. 143, 107530. https://doi.org/10.1016/j.leukres.2024.107530
Khosla, A, Inoue, Y, Cioccio, J, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Ehmann, C, Claxton, D, Rybka, W, Sivik, J, Mierski, J, Silar, B, Vajdic, C, Hohl, R, Shike, H, Mineishi, S & Minagawa, K 2024, 'Recurrent disease after a matched sibling hematopoietic transplant in an aplastic anemia patient with a disease risk allele, HLA-B*40:02', Blood Transfusion, vol. 22, no. 6, pp. 525-528. https://doi.org/10.2450/BloodTransfus.674
Zhang, R, Shang, Y, Cioccio, J, Rakszawski, K, Nickolich, M, Ehmann, C, Inoue, Y, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Liao, J, Greiner, R, Brown, V, Claxton, D, Ning, J, Zhou, S, Mineishi, S, Minagawa, K & Shike, H 2024, 'Sensitivity and Specificity of Chimerism Tests in Predicting Leukemia Relapse Using Increasing Mixed Chimerism', Journal of Molecular Diagnostics, vol. 26, no. 12, pp. 1159-1170. https://doi.org/10.1016/j.jmoldx.2024.09.003
Guare, EG, Hale, CM, Sivik, J, Lehman, E, Inoue, Y, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Claxton, D, Rybka, W, Hohl, R, Mineishi, S, Minagawa, K & Paules, CI 2024, 'The addition of doxycycline to fluoroquinolones for bacterial prophylaxis in autologous stem cell transplantation for multiple myeloma', Transplant Infectious Disease, vol. 26, no. 2, e14241. https://doi.org/10.1111/tid.14241
2023
Garcia-Manero, G, Podoltsev, NA, Othus, M, Pagel, JM, Radich, JP, Fang, M, Rizzieri, DA, Marcucci, G, Strickland, SA, Litzow, MR, Savoie, ML, Medeiros, BC, Sekeres, MA, Lin, TL, Uy, GL, Powell, BL, Kolitz, JE, Larson, RA, Stone, RM, Claxton, D, Essell, J, Luger, SM, Mohan, SR, Moseley, A, Appelbaum, FR & Erba, HP 2023, 'A randomized phase III study of standard versus high-dose cytarabine with or without vorinostat for AML', Leukemia. https://doi.org/10.1038/s41375-023-02073-x
Ung, J, Tan, SF, Fox, TE, Shaw, JJP, Taori, M, Horton, BJ, Golla, U, Sharma, A, Szulc, ZM, Wang, H-G, Chalfant, CE, Cabot, MC, Claxton, DF, Loughran, TP & Feith, DJ 2023, 'Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia', Cancers, vol. 15, no. 24, 5866. https://doi.org/10.3390/cancers15245866
Qian, F, Nettleford, SK, Zhou, J, Arner, BE, Hall, MA, Sharma, A, Annageldiyev, C, Rossi, RM, Tukaramrao, DB, Sarkar, D, Hegde, S, Gandhi, UH, Finch, ER, Goodfield, L, Quickel, MD, Claxton, DF, Paulson, RF & Prabhu, KS 2023, 'Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells', Cell Reports, vol. 42, no. 7, 112794. https://doi.org/10.1016/j.celrep.2023.112794
Jia, B, Zhao, C, Minagawa, K, Shike, H, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Wang, M, Schell, TD, Prabhu, KS, Paulson, RF, Zhang, Y, Shultz, LD & Zheng, H 2023, 'Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model', Journal of Immunology, vol. 211, no. 9, pp. 1426-1437. https://doi.org/10.4049/jimmunol.2300111
Potiaumpai, M, Schmitz, KH, Mineishi, S, Naik, S, Wirk, B, Rakszawski, K, Ehmann, WC, Claxton, D, Nickolich, M, Zemel, BS & Zheng, H 2023, 'IMPROVE-BMT: A protocol for a pilot randomised controlled trial of prehabilitation exercise for adult haematopoietic stem cell transplant recipients', BMJ open, vol. 13, no. 1, e066841. https://doi.org/10.1136/bmjopen-2022-066841
Levy, B, Baughn, LB, Akkari, Y, Chartrand, S, LaBarge, B, Claxton, D, Lennon, PA, Cujar, C, Kolhe, R, Kroeger, K, Pitel, B, Sahajpal, N, Sathanoori, M, Vlad, G, Zhang, L, Fang, M, Kanagal-Shamanna, R & Broach, JR 2023, 'Optical genome mapping in acute myeloid leukemia: a multicenter evaluation', Blood Advances, vol. 7, no. 7, pp. 1297-1307. https://doi.org/10.1182/bloodadvances.2022007583
Fisher-Wellman, KH, Kassai, M, Hagen, JT, Neufer, PD, Kester, M, Loughran, TP, Chalfant, CE, Feith, DJ, Tan, SF, Fox, TE, Ung, J, Fabrias, G, Abad, JL, Sharma, A, Golla, U, Claxton, DF, Shaw, JJP, Bhowmick, D & Cabot, MC 2023, 'Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia', Cancers, vol. 15, no. 6, 1883. https://doi.org/10.3390/cancers15061883
Aldoss, I, Yin, J, Wall, A, Mrózek, K, Liedtke, M, Claxton, DF, Foster, MC, Appelbaum, FR, Erba, HP, Litzow, MR, Tallman, MS, Stone, RM, Larson, RA, Advani, AS, Stock, W & Luger, SM 2023, 'The impact of early PEG-asparaginase discontinuation in young adults with ALL: a post hoc analysis of the CALGB 10403 study', Blood Advances, vol. 7, no. 2, pp. 196-204. https://doi.org/10.1182/bloodadvances.2022007791
2022
Long, NA, Golla, U, Sharma, A & Claxton, DF 2022, 'Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications', Stem Cell Reviews and Reports, vol. 18, no. 4, pp. 1211-1226. https://doi.org/10.1007/s12015-021-10308-6
Fisher-Wellman, KH, Hagen, JT, Kassai, M, Kao, LP, Nelson, MAM, McLaughlin, KL, Coalson, HS, Fox, TE, Tan, SF, Feith, DJ, Kester, M, Loughran, TP, Claxton, DF & Cabot, MC 2022, 'Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia', FASEB Journal, vol. 36, no. 1, e22094. https://doi.org/10.1096/fj.202101194RRR
Claxton, DF 2022, 'Beware clonal haematopoiesis following chronic lymphocytic leukaemia treatment', British Journal of Haematology, vol. 198, no. 1, pp. 9-10. https://doi.org/10.1111/bjh.18174
Khokhlatchev, AV, Sharma, A, Deering, TG, Shaw, JJP, Costa-Pinheiro, P, Golla, U, Annageldiyev, C, Cabot, MC, Conaway, MR, Tan, SF, Ung, J, Feith, DJ, Loughran, TP, Claxton, DF, Fox, TE & Kester, M 2022, 'Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia', FASEB Journal, vol. 36, no. 10, e22514. https://doi.org/10.1096/fj.202200765R
Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2023, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology, vol. 102, no. 3, pp. 613-620. https://doi.org/10.1007/s00277-022-05077-2
Ung, J, Tan, SF, Fox, TE, Shaw, JJP, Vass, LR, Costa-Pinheiro, P, Garrett-Bakelman, FE, Keng, MK, Sharma, A, Claxton, DF, Levine, RL, Tallman, MS, Cabot, MC, Kester, M, Feith, DJ & Loughran, TP 2022, 'Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia', Blood Reviews, vol. 55, 100950. https://doi.org/10.1016/j.blre.2022.100950
Qian, F, Arner, BE, Kelly, KM, Annageldiyev, C, Sharma, A, Claxton, DF, Paulson, RF & Prabhu, KS 2022, 'Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia', FASEB Journal, vol. 36, no. 5, e22328. https://doi.org/10.1096/fj.202200251R
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Pizzola, CJ, Cioccio, J, Rakszawski, KL, Nickolich, M, Ehmann, WC, Rybka, WB, Wirk, B, Naik, S, Zheng, H, Silar, B, Shike, H, Zhou, S, Mineishi, S, Minagawa, K & Claxton, DF 2022, 'Non-myeloablative allogeneic stem cell transplant with fludarabine and reduced dose cyclophosphamide in acute myeloid leukemia for older adults with comorbidities', Bone Marrow Transplantation, vol. 57, no. 11, pp. 1743-1745. https://doi.org/10.1038/s41409-022-01821-4
Zhao, C, Bartock, M, Jia, B, Shah, N, Claxton, DF, Wirk, B, Rakszawski, KL, Nickolich, MS, Naik, SG, Rybka, WB, Ehmann, WCC, Hohl, RJ, Valentin, J, Bernas-Peterson, M, Gerber, EM, Zimmerman, M, Mierski, JA, Mineishi, S & Zheng, H 2022, 'Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant', Journal of Hematology and Oncology, vol. 15, no. 1, 64. https://doi.org/10.1186/s13045-022-01287-3
Xu, J, Song, F, Lyu, H, Kobayashi, M, Zhang, B, Zhao, Z, Hou, Y, Wang, X, Luan, Y, Jia, B, Stasiak, L, Wong, JHY, Wang, Q, Jin, Q, Jin, Q, Fu, Y, Yang, H, Hardison, RC, Dovat, S, Platanias, LC, Diao, Y, Yang, Y, Yamada, T, Viny, AD, Levine, RL, Claxton, D, Broach, JR, Zheng, H & Yue, F 2022, 'Subtype-specific 3D genome alteration in acute myeloid leukaemia', Nature, vol. 611, no. 7935, pp. 387-398. https://doi.org/10.1038/s41586-022-05365-x
Ehudin, MA, Golla, U, Trivedi, D, Potlakayala, SD, Rudrabhatla, SV, Desai, D, Dovat, S, Claxton, D & Sharma, A 2022, 'Therapeutic Benefits of Selenium in Hematological Malignancies', International journal of molecular sciences, vol. 23, no. 14, 7972. https://doi.org/10.3390/ijms23147972
2021
Jia, B, Zhao, C, Bayerl, M, Shike, H, Claxton, DF, Ehmann, WC, Mineishi, S, Schell, TD, Zheng, P, Zhang, Y, Shultz, LD, Prabhu, KS, Paulson, RF & Zheng, H 2022, 'A novel clinically relevant graft-versus-leukemia model in humanized mice', Journal of Leukocyte Biology, vol. 111, no. 2, pp. 427-437. https://doi.org/10.1002/JLB.5AB0820-542RR
Advani, AS, Larsen, E, Laumann, K, Luger, SM, Liedtke, M, Devidas, M, Chen, Z, Yin, J, Foster, MC, Claxton, D, Coffan, K, Tallman, MS, Appelbaum, FR, Erba, H, Stone, RM, Hunger, SP, McNeer, JL, Loh, ML, Raetz, E, Winick, N, Carroll, W, Larson, RA & Stock, W 2021, 'Comparison of CALGB 10403 (Alliance) and COG AALL0232 toxicity results in young adults with acute lymphoblastic leukemia', Blood Advances, vol. 5, no. 2, pp. 504-512. https://doi.org/10.1182/bloodadvances.2020002439
Golla, U, Ehudin, MA, Annageldiyev, C, Zeng, Z, Bastihalli Tukaramrao, D, Tarren, A, Date, AA, Elcheva, I, Berg, A, Amin, S, Loughran, TP, Kester, M, Desai, D, Dovat, S, Claxton, D & Sharma, A 2021, 'Dj4 targets the rho-associated protein kinase pathway and attenuates disease progression in preclinical murine models of acute myeloid leukemia', Cancers, vol. 13, no. 19, 4889. https://doi.org/10.3390/cancers13194889
Zhu, G, Luo, H, Feng, Y, Guryanova, OA, Xu, J, Chen, S, Lai, Q, Sharma, A, Xu, B, Zhao, Z, Feng, R, Ni, H, Claxton, D, Guo, Y, Mesa, RA, Qiu, Y, Yang, FC, Li, W, Nimer, SD, Huang, S & Xu, M 2021, 'HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia', Nature communications, vol. 12, no. 1, 1956. https://doi.org/10.1038/s41467-021-22095-2
Shah, N, Rakszawski, K, Nickolich, M, Ehmann, C, Wirk, B, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Mackey, G, Greiner, R, Brown, V, Claxton, D, Mineishi, S & Minagawa, K 2021, 'Improved outcome in AML relapse after allogeneic transplant with high-intensity chemotherapy followed by 2nd allogeneic stem cell transplant or donor lymphocyte infusion', Annals of Hematology, vol. 100, no. 10, pp. 2585-2592. https://doi.org/10.1007/s00277-021-04616-7
List, AF, Sun, Z, Verma, A, Bennett, JM, Komrokji, RS, McGraw, K, Maciejewski, J, Altman, JK, Cheema, PS, Claxton, DF, Luger, SM, Mattison, RJ, Wassenaar, TR, Artz, AS, Schiffer, CA, Litzow, MR & Tallman, MS 2021, 'Lenalidomide-Epoetin Alfa Versus Lenalidomide Monotherapy in Myelodysplastic Syndromes Refractory to Recombinant Erythropoietin', Journal of Clinical Oncology, vol. 39, no. 9, pp. 1001-1009. https://doi.org/10.1200/JCO.20.01691
Klink, M, Rahman, MA, Song, C, Dhanyamraju, PK, Ehudin, M, Ding, Y, Steffens, S, Bhadauria, P, Iyer, S, Aliaga, C, Desai, D, Huang, S, Claxton, D, Sharma, A & Gowda, C 2021, 'Mechanistic basis for in vivo therapeutic efficacy of ck2 inhibitor cx-4945 in acute myeloid leukemia', Cancers, vol. 13, no. 5, 1127, pp. 1-21. https://doi.org/10.3390/cancers13051127
Kantarjian, HM, Begna, KH, Altman, JK, Goldberg, SL, Sekeres, MA, Strickland, SA, Arellano, ML, Claxton, DF, Baer, MR, Gautier, M, Berman, E, Seiter, K, Solomon, SR, Schiller, GJ, Luger, SM, Butrym, A, Gaidano, G, Thomas, XG, Montesinos, P, Rizzieri, DA, Quick, DP, Venugopal, P, Gaur, R, Maness, LJ, Kadia, TM, Ravandi, F, Buyse, ME & Chiao, JH 2021, 'Results of a randomized phase 3 study of oral sapacitabine in elderly patients with newly diagnosed acute myeloid leukemia (SEAMLESS)', Cancer, vol. 127, no. 23, pp. 4421-4431. https://doi.org/10.1002/cncr.33828
Gvozdjan, K, Casey, H, Mowery, C, Kumer, L, Fisher, C, Tyler, J, Bayerl, MG, Malysz, J, Naik, S, Rybka, W, Ehmann, C, Claxton, D, Mineishi, S, Baker, M, Hong, Z & Shike, H 2021, 'Unexpected Short-Tandem-Repeat Patterns in Post-Transplant Chimerism Testing: Investigation of 3 Cases with Help from Forensic Science', Laboratory Medicine, vol. 51, no. 6, pp. 635-641. https://doi.org/10.1093/LABMED/LMAA022