Researcher Profile

Researcher Profile

David Claxton, MD

David Claxton, MD

Professor, Department of Medicine
Division of Hematology and Oncology
Scientific Program:Experimental Therapeutics
Disease Teams:
Bone Marrow Transplantation
Immunotherapy
Leukemia and Lymphoma
dfc10@psu.edu

Research Interests

Dr. David Claxton has longstanding interests in leukemia biology and therapeutics. Leukemia molecular genetics and diagnostics are ongoing interests. Acute myeloid leukemia and related disorders are his principal foci. Leukemia therapeutics are particular interests, including drug development and clinical studies, blood and marrow transplantation, and clinical supportive care. He has a laboratory which has banked many samples of human leukemias and lymphomas. These are viably cryopreserved, used in studies and available to collaborators.

  • Acute Myeloid Leukemia
  • Therapeutics
  • Leukemia
  • Neoplasms
  • Bone Marrow
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Genes
  • T-Lymphocytes
  • Proteins
  • Drug Therapy
  • Stem Cells
  • Transplants

Clinical Trials

Blood and Bone Marrow Collection from Patients with Hematological Malignancies for Study of Anti-Tumor Immunity
Biologic Studies of Experimental Anti-Cancer Therapeutics in Human Leukemia Cells
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
T-Cell Exhaustion in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
Protocol for a Research Database for Hematopoietic Cell Transplantation, other Cellular Therapies and Marrow Toxic Injuries.

Recent Publications

2019

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Kempin, S, Sun, Z, Kay, NE, Paietta, EM, Mazza, JJ, Ketterling, RP, Frankfurt, O, Claxton, D, Saltzman, JN, Srkalovic, G, Callander, NS, Gross, G & Tallman, MS 2019, 'Pentostatin, Cyclophosphamide, and Rituximab Followed by Alemtuzumab for Relapsed or Refractory Chronic Lymphocytic Leukemia: A Phase 2 Trial of the ECOG-Acrin Cancer Research Group (E2903)', Acta Haematologica. https://doi.org/10.1159/000500164
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2018

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Kokolus, KM, Haley, JS, Koubek, EJ, Gowda, R, Dinavahi, SS, Sharma, A, Claxton, D, Helm, K, Drabick, J, Robertson, G, Neighbors, J, Hohl, R & Schell, T 2019, 'Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity', OncoImmunology, vol. 8, no. 2, e1539614. https://doi.org/10.1080/2162402X.2018.1539614
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McGill, CM, Tomco, PL, Ondrasik, RM, Belknap, KC, Dwyer, GK, Quinlan, DJ, Kircher, TA, Andam, CP, Brown, TJ, Claxton, D & Barth, BM 2018, 'Therapeutic effect of Northern Labrador tea extracts for acute myeloid leukemia' Phytotherapy Research, vol. 32, no. 8, pp. 1636-1641. https://doi.org/10.1002/ptr.6091
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2017

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Hengst, J, Dick, TE, Sharma, A, Doi, K, Hegde, S, Tan, SF, Geffert, L, Fox, TE, Sharma, AK, Desai, D, Amin, S, Kester, M, Loughran, TP, Paulson, R, Claxton, D, Wang, H-G & Yun, J 2017, 'SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models' Cancer Translational Medicine, vol. 3, no. 4, pp. 109-121.
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2016

Kirschbaum, MH, Frankel, P, Synold, TW, Zain, J, Claxton, D, Tuscano, J, Newman, EM, Gandara, DR & Lara, PN 2018, 'A phase II study of vascular endothelial growth factor trap (Aflibercept, NSC 724770) in patients with myelodysplastic syndrome: a California Cancer Consortium Study', British Journal of Haematology, vol. 180, no. 3, pp. 445-448. https://doi.org/10.1111/bjh.14333
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2015

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Robuccio, A, Ssentongo, P, Sather, M, Claxton, D & Gilliam, FG 2015, 'Intractable myoclonic seizures in an allogeneic stem cell transplant recipient: A rare case of myoclonic epilepsy', Epilepsy and Behavior Case Reports, vol. 4, pp. 48-51. https://doi.org/10.1016/j.ebcr.2015.06.005
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Abbi, KKS, Rybka, W, Ehmann, WC & Claxton, D 2015, 'Phase I/II study of clofarabine, etoposide, and mitoxantrone in patients with refractory or relapsed acute leukemia' Clinical Lymphoma, Myeloma and Leukemia, vol. 15, no. 1, pp. 41-46. https://doi.org/10.1016/j.clml.2014.06.005

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)