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Researcher Profile

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Dawit Aregawi, MD

Dawit Aregawi, MD

Assistant Professor, Department of Neurosurgery
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Brain and Central Nervous System Cancer Team
DXA22@psu.edu

Research Interests

  • Therapeutics
  • Polycystic Ovary Syndrome
  • Glioblastoma
  • Neoplasms
  • Diet
  • Metformin
  • Glioma
  • Mutation
  • Thrombophilia
  • Radiation
  • Drug Therapy
  • Weights and Measures

Clinical Trials

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Enzastaurin Added to Temozolomide During and Following Radiation Therapy in Newly Diagnosed Glioblastoma Patients Who Possess the Novel Genomic Biomarker DGM1
Phase II Pilot RCT to assess feasibility of supra-marginal surgical resection of malignant glioma (G-SUMIT: Glioma Supra Marginal Incision Trial)
3D-PREDICT Registry: 3D Prediction of patient-specific Response using ex vivo Interrogation of live cells from tumors
Maintenance Obinutuzumab for Primary Central Nervous System Lymphoma Complete Responders
An open-label phase II study to investigate the efficacy, safety, and pharmacokinetics of tirabrutinib in patients with Primary Central Nervous System Lymphoma (PCNSL)

Recent Publications

2022

Yee, PP, Wang, J, Chih, SY, Aregawi, DG, Glantz, MJ, Zacharia, BE, Thamburaj, K & Li, W 2022, 'Temporal radiographic and histological study of necrosis development in a mouse glioblastoma model', Frontiers in Oncology, vol. 12, 993649. https://doi.org/10.3389/fonc.2022.993649

2021

Fu, S, Piccioni, DE, Liu, H, Lukas, RV, Kesari, S, Aregawi, D, Hong, DS, Yamaguchi, K, Whicher, K, Zhang, Y, Chen, YL, Poola, N, Eddy, J & Blum, D 2021, 'A phase I study of the WT2725 dosing emulsion in patients with advanced malignancies', Scientific reports, vol. 11, no. 1, 22355. https://doi.org/10.1038/s41598-021-01707-3
Khristov, V, Shenoy, G, Mau, C, Mrowczynski, O, Rizk, E, Pu, C, Specht, CS & Aregawi, D 2022, 'Myxopapillary Ependymoma with Anaplastic Features: A Case Series and Review of the Literature', World neurosurgery, vol. 158, pp. e735-e745. https://doi.org/10.1016/j.wneu.2021.11.053

2020

Yee, PP, Wei, Y, Kim, SY, Lu, T, Chih, SY, Lawson, C, Tang, M, Liu, Z, Anderson, B, Thamburaj, K, Young, MM, Aregawi, DG, Glantz, MJ, Zacharia, BE, Specht, CS, Wang, HG & Li, W 2020, 'Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression', Nature communications, vol. 11, no. 1, 5424. https://doi.org/10.1038/s41467-020-19193-y

2019

Payne, R, Mrowczynski, OD, Slagle-Webb, B, Bourcier, A, Mau, C, Aregawi, D, Madhankumar, AB, Lee, SY, Harbaugh, K, Connor, J & Rizk, EB 2019, 'MLN8237 treatment in an orthoxenograft murine model for malignant peripheral nerve sheath tumors', Journal of neurosurgery, vol. 130, no. 2, pp. 465-475. https://doi.org/10.3171/2017.8.JNS17765
Brown, TJ, Bota, DA, Van Den Bent, MJ, Brown, PD, Maher, E, Aregawi, D, Liau, LM, Buckner, JC, Weller, M, Berger, MS & Glantz, M 2019, 'Management of low-grade glioma: A systematic review and meta-Analysis', Neuro-Oncology Practice, vol. 6, no. 4, npy034, pp. 249-258. https://doi.org/10.1093/nop/npy034