Dawit Aregawi, MD - Penn State Cancer Institute
Researcher Profile
Dawit Aregawi, MD
Assistant Professor, Department of Neurosurgery
Penn State Neuroscience Institute
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Brain and Central Nervous System Cancer Team
Clinical Trials
Integration of CSF proteogenomics in the diagnosis and management of diffuse gliomas
A Randomized, Open-label, Multicentric, Two-arm Pivotal Trial of SonoCloud-9 Combined With Carboplatin (CBDCA) vs Standard of Care Lomustine (CCNU) or Temozolomide (TMZ) in Patients Undergoing Planned Resection for First Recurrence Glioblastoma
3D-PREDICT Registry: 3D Prediction of patient-specific Response using ex vivo Interrogation of live cells from tumors
Maintenance Obinutuzumab for Primary Central Nervous System Lymphoma Complete or Partial Responders
An open-label phase II study to investigate the efficacy, safety, and pharmacokinetics of tirabrutinib in patients with Primary Central Nervous System Lymphoma (PCNSL)
Recent Publications
2025
Tuohy, K, Dowd, R, Ali, A, Badani, A, Sichinga, K, Zacharia, BE, Mansouri, SA, Aregawi, D & Glantz, M 2025, 'Medical Therapy Alone for Ommaya Reservoir–Associated Bacterial Meningitis: When It Works and When It Fails', Neurosurgery. https://doi.org/10.1227/neu.0000000000003310
2024
Lu, T, Yee, PP, Chih, SY, Tang, M, Chen, H, Aregawi, DG, Glantz, MJ, Zacharia, BE, Wang, H-G & Li, W 2024, 'LC3-associated phagocytosis of neutrophils triggers tumor ferroptotic cell death in glioblastoma', EMBO Journal, vol. 43, no. 13, pp. 2582-2605. https://doi.org/10.1038/s44318-024-00130-4
Mikolajewicz, N, Yee, PP, Bhanja, D, Trifoi, M, Miller, AM, Metellus, P, Bagley, SJ, Balaj, L, De MacEdo Filho, LJM, Zacharia, BE, Aregawi, D, Glantz, M, Weller, M, Ahluwalia, MS, Kislinger, T & Mansouri, SA 2024, 'Systematic Review of Cerebrospinal Fluid Biomarker Discovery in Neuro-Oncology: A Roadmap to Standardization and Clinical Application', Journal of Clinical Oncology, vol. 42, no. 16, pp. 1961-1974. https://doi.org/10.1200/JCO.23.01621
Demirsoy, S, Tran, H, Liu, J, Li, Y, Yang, S, Aregawi, D, Glantz, MJ, Jacob, NK, Walter, V, Schell, TD & Olmez, I 2024, 'Targeting Tyro3, Axl, and MerTK Receptor Tyrosine Kinases Significantly Sensitizes Triple-Negative Breast Cancer to CDK4/6 Inhibition', Cancers, vol. 16, no. 12, 2253. https://doi.org/10.3390/cancers16122253
2023
Ranjan, T, Sengupta, S, Glantz, MJ, Green, RM, Yu, A, Aregawi, D, Chaudhary, R, Chen, R, Zuccarello, M, Lu-Emerson, C, Moulding, HD, Belman, N, Glass, J, Mammoser, A, Anderson, M, Valluri, J, Marko, N, Schroeder, J, Jubelirer, S, Chow, F, Claudio, PP, Alberico, AM, Lirette, ST, Denning, KL & Howard, CM 2023, 'Cancer stem cell assay-guided chemotherapy improves survival of patients with recurrent glioblastoma in a randomized trial', Cell Reports Medicine, vol. 4, no. 5, 101025. https://doi.org/10.1016/j.xcrm.2023.101025
Hertler, C, Felsberg, J, Gramatzki, D, Le Rhun, E, Clarke, J, Soffietti, R, Wick, W, Chinot, O, Ducray, F, Roth, P, McDonald, K, Hau, P, Hottinger, AF, Reijneveld, J, Schnell, O, Marosi, C, Glantz, M, Darlix, A, Lombardi, G, Krex, D, Glas, M, Reardon, DA, van den Bent, M, Lefranc, F, Herrlinger, U, Razis, E, Carpentier, AF, Phillips, S, Rudà, R, Wick, A, Tabouret, E, Meyronet, D, Maurage, CA, Rushing, E, Rapkins, R, Bumes, E, Hegi, M, Weyerbrock, A, Aregawi, D, Gonzalez-Gomez, C, Pellerino, A, Klein, M, Preusser, M, Bendszus, M, Golfinopoulos, V, von Deimling, A, Gorlia, T, Wen, PY, Reifenberger, G & Weller, M 2023, 'Long-term survival with IDH wildtype glioblastoma: first results from the ETERNITY Brain Tumor Funders’ Collaborative Consortium (EORTC 1419)', European Journal of Cancer, vol. 189, 112913. https://doi.org/10.1016/j.ejca.2023.05.002
2022
Yee, PP, Wang, J, Chih, SY, Aregawi, DG, Glantz, MJ, Zacharia, BE, Thamburaj, K & Li, W 2022, 'Temporal radiographic and histological study of necrosis development in a mouse glioblastoma model', Frontiers in Oncology, vol. 12, 993649. https://doi.org/10.3389/fonc.2022.993649
2021
Fu, S, Piccioni, DE, Liu, H, Lukas, RV, Kesari, S, Aregawi, D, Hong, DS, Yamaguchi, K, Whicher, K, Zhang, Y, Chen, YL, Poola, N, Eddy, J & Blum, D 2021, 'A phase I study of the WT2725 dosing emulsion in patients with advanced malignancies', Scientific reports, vol. 11, no. 1, 22355. https://doi.org/10.1038/s41598-021-01707-3
Khristov, V, Shenoy, G, Mau, C, Mrowczynski, O, Rizk, E, Pu, C, Specht, CS & Aregawi, D 2022, 'Myxopapillary Ependymoma with Anaplastic Features: A Case Series and Review of the Literature', World neurosurgery, vol. 158, pp. e735-e745. https://doi.org/10.1016/j.wneu.2021.11.053
Mrowczynski, OD, Vasekar, M, Fox, E, Harbaugh, K, Aregawi, D, Pameijer, CR, Zaorsky, N, Payne, R & Rizk, E 2021, 'Spontaneous Hip Dislocation Complicating the Management of Malignant Peripheral Nerve Sheath Tumor Arising Within a Plexiform Neurofibroma', Cureus, vol. 13, no. 7, e16320. https://doi.org/10.7759/cureus.16320
Mansouri, A, Padmanaban, V, Aregawi, D & Glantz, M 2021, 'VEGF and Immune Checkpoint Inhibition for Prevention of Brain Metastases: Systematic Review and Meta-analysis', Neurology, vol. 97, no. 15, pp. E1484-E1492. https://doi.org/10.1212/WNL.0000000000012642