Researcher Profile

Researcher Profile

Joseph Drabick, MD

Joseph Drabick, MD

Rose Dunlap Division Chief Chair in Hematology/Oncology, Department of Medicine
Chief, Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Central Nervous System Cancer
Genitourinary Cancer
Immunotherapy
Melanoma and Skin Cancer
Sarcoma Cancer
jjd25@psu.edu

Research Interests

  • Therapeutics
  • Neoplasms
  • Melanoma
  • Survival
  • Haiti
  • United Nations
  • Vaccines
  • Infection
  • Skin
  • Drug Therapy
  • Antibodies
  • Immunotherapy

Clinical Trials

Development and Validation of a Gene Expression Assay to Predict the Risk of Recurrent Disease in Cutaneous Squamous Cell Carcinoma
Single Arm Phase Ib/II Study of Durvalumab and Guadecitabine in Advanced Kidney Cancer: Big Ten Cancer Research Consortium BTCRC-GU16-043
A Phase III Randomized Study Comparing Perioperative Nivolumab vs. Observation in Patients with Localized Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC)
A Phase 1b-2 Study to Evaluate Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Erdafitinib plus JNJ-63723283 (Cetrelimab), an Anti-PD-1 Monoclonal Antibody, in Subjects with Metastatic or Locally Advanced Urothelial Cancer with Selected FGFR Gene Alterations
Targeting PIM1 and CDK4/6 Kinases in Renal Cell Carcinoma (PICKRCC): A Phase Ib study of Abemaciclib in Combination with Sunitinib in metastatic RCC
Performance of the DecisionDx-Melanoma Gene Expression Profile Test for Prognosis of Recurrence Risk
STAMP: Surgically Treated Adjuvant Merkel cell carcinoma with Pembrolizumab, a Phase III Trial
Phase III Randomized Trial Of Concurrent Chemoradiotherapy With or Without Atezoluzumab in Localized Muscle Invasive Bladder Cancer
General Protocol for the Acquisition of Whole Blood for the Detection and Characterization of Circulating Tumor Cells and/or Tumor Specific Immunity/Immune Cell Activation for any Malignancy at any Stage of Disease
Enhancing Patient Resilience During Multimodal Therapy for Bladder Cancer
Definition of Somatic Variants Corresponding to Immune Targets in Patients with Metastatic Melanoma
A Retrospective Evaluation to Understand how â-adrenergic Antagonism Impacts the Progression of Melanoma and the Efficacy of Standard Treatments Intended to Eliminate the Cancer
Observational Study to Determine the Differences in Molecular Characterization between Smokers vs. Non-smokers in Patients with Stage IV Bladder Cancer and their Correlation with Clinical Outcome

Recent Publications

2020

Rao, P, Segel, JE, McGregor, LM, Lengerich, EJ, Drabick, JJ & Miller, B 2020, 'Attendance at National Cancer Institute and Children's Oncology Group Facilities for Children, Adolescents, and Young Adults with Cancer in Pennsylvania: A Population-Based Study', Journal of Adolescent and Young Adult Oncology, vol. 9, no. 1, pp. 47-54. https://doi.org/10.1089/jayao.2019.0045
Liu, J, Xu, C, Zhu, J, Sivik, J, Drabick, JJ & Mackley, HB 2020, 'Identifying the optimal fractionation schedules for improved response rates and survival in patients with metastatic melanoma treated with ipilimumab and radiotherapy', Current Cancer Therapy Reviews, vol. 16, no. 1, pp. 78-85. https://doi.org/10.2174/2542584601666180326111906
Hendriksen, BS, Stahl, KA, Hollenbeak, CS, Taylor, MD, Vasekar, MK, Drabick, JJ, Conte, JV, Soleimani, B & Reed, MF 2020, 'Postoperative chemotherapy and radiation improve survival following cardiac sarcoma resection', Journal of Thoracic and Cardiovascular Surgery. https://doi.org/10.1016/j.jtcvs.2019.10.016

2019

Willumsen, N, Ali, SM, Leitzel, K, Drabick, JJ, Yee, N, Polimera, HV, Nagabhairu, V, Krecko, L, Ali, A, Maddukuri, A, Moku, P, Ali, A, Poulose, J, Menon, H, Pancholy, N, Costa, L, Karsdal, MA & Lipton, A 2019, 'Collagen fragments quantified in serum as measures of desmoplasia associate with survival outcome in patients with advanced pancreatic cancer', Scientific reports, vol. 9, no. 1, 19761. https://doi.org/10.1038/s41598-019-56268-3
Zhu, J, Hussain, M, Joshi, A, Truica, CI, Nesterova, D, Collins, J, Saunders, EFH, Hayes, M, Drabick, JJ & Joshi, M 2020, 'Effect of creative writing on mood in patients with cancer', BMJ Supportive and Palliative Care, vol. 10, no. 1, pp. 64-67. https://doi.org/10.1136/bmjspcare-2018-001710
Jia, B, Zhao, C, Rakszawski, KL, Claxton, DF, Christopher Ehmann, W, Rybka, WB, Mineishi, S, Wang, M, Shike, H, Bayerl, MG, Sivik, JM, Schell, TD, Drabick, JJ, Hohl, RJ & Zheng, H 2019, 'Eomes+T-betlow CD8+ T cells are functionally impaired and are associated with poor clinical outcome in patients with acute myeloid leukemia', Cancer Research, vol. 79, no. 7, pp. 1635-1645. https://doi.org/10.1158/0008-5472.CAN-18-3107
Cummings, M, Lehrer, EJ, Drabick, J, Gusani, NJ, Trifiletti, DM & Zaorsky, N 2019, 'Exceptional responders in oncology: A systematic review and meta-analysis of patient level data', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 42, no. 8, pp. 624-635. https://doi.org/10.1097/COC.0000000000000572
Zaleski, M, Gogoj, A, Walter, V, Raman, JD, Kaag, M, Merrill, SB, Drabick, J, Joshi, M, Holder, S, DeGraff, DJ & Warrick, JI 2019, 'Mitotic activity in noninvasive papillary urothelial carcinoma: its value in predicting tumor recurrence and comparison with the contemporary 2-tier grading system', Human Pathology, vol. 84, pp. 275-282. https://doi.org/10.1016/j.humpath.2018.10.008
Joshi, M, Warrick, JI, Yin, M, Holder, SL & Drabick, JJ 2019, 'Need for a personalized approach for muscle invasive bladder cancer: Role of tumor biology in response to neoadjuvant chemotherapy', Translational Andrology and Urology, vol. 8, pp. S99-S103. https://doi.org/10.21037/tau.2018.12.04

2018

Yin, M, Grivas, P, Emamekhoo, H, Mendiratta, P, Ali, S, Hsu, JA, Vasekar, M, Drabick, JJ, Pal, S & Joshi, M 2018, 'ATM/RB1 mutations predict shorter overall survival in urothelial cancer', Oncotarget, vol. 9, no. 24, pp. 16891-16898. https://doi.org/10.18632/oncotarget.24738
Sivik, JM, Davidson, J, Hale, CM, Drabick, JJ & Talamo, G 2018, 'Addition of doxycycline to ciprofloxacin for infection prophylaxis during autologous stem cell transplants for multiple myeloma', Supportive Care in Cancer, vol. 26, no. 9, pp. 3055-3061. https://doi.org/10.1007/s00520-018-4165-6
Tian, Y, Fox, E, Drabick, J & Pameijer, C 2018, 'Isolated limb infusion as a treatment option for malignant granular cell tumour', BMJ case reports, vol. 2018, 224618. https://doi.org/10.1136/bcr-2018-224618
Dinavahi, SS, Noory, MA, Gowda, R, Drabick, J, Berg, A, Neves, R & Robertson, G 2018, 'Moving synergistically acting drug combinations to the clinic by comparing sequential versus simultaneous drug administrations', Molecular pharmacology, vol. 93, no. 3, pp. 190-196. https://doi.org/10.1124/mol.117.110759
Patel, UH, Drabick, JJ, Malysz, J & Talamo, G 2018, 'Nonsecretory and Light Chain Escape in Patients With Multiple Myeloma', Clinical Lymphoma, Myeloma and Leukemia, vol. 18, no. 12, pp. e515-e519. https://doi.org/10.1016/j.clml.2018.06.028
Kokolus, KM, Haley, JS, Koubek, EJ, Gowda, R, Dinavahi, SS, Sharma, A, Claxton, DF, Helm, KF, Drabick, JJ, Robertson, GP, Neighbors, JD, Hohl, RJ & Schell, TD 2019, 'Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity', OncoImmunology, vol. 8, no. 2, e1539614. https://doi.org/10.1080/2162402X.2018.1539614
Ribas, A, Medina, T, Kummar, S, Amin, A, Kalbasi, A, Drabick, JJ, Barve, M, Daniels, GA, Wong, DJ, Schmidt, EV, Candia, AF, Coffman, RL, Leung, ACF & Janssen, RS 2018, 'Sd-101 in combination with pembrolizumab in advanced melanoma: Results of a phase ib, multicenter study', Cancer Discovery, vol. 8, no. 10. https://doi.org/10.1158/2159-8290.CD-18-0280

2017

Kokolus, KM, Zhang, Y, Sivik, JM, Schmeck, C, Zhu, J, Repasky, EA, Drabick, JJ & Schell, TD 2018, 'Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice', OncoImmunology, vol. 7, no. 3, e1405205. https://doi.org/10.1080/2162402X.2017.1405205
Kuzu, OF, Gowda, R, Sharma, A, Noory, MA, Kardos, G, Madhunapantula, SRV, Drabick, JJ & Robertson, GP 2018, 'Identification of WEE1 as a target to make AKT inhibition more effective in melanoma', Cancer Biology and Therapy, vol. 19, no. 1, pp. 53-62. https://doi.org/10.1080/15384047.2017.1360446
Koller, KM, Mackley, HB, Liu, J, Wagner, H, Talamo, G, Schell, TD, Pameijer, C, Neves, RI, Anderson, B, Kokolus, KM, Mallon, CA & Drabick, JJ 2017, 'Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone', Cancer Biology and Therapy, vol. 18, no. 1, pp. 36-42. https://doi.org/10.1080/15384047.2016.1264543
Kuzu, OF, Gowda, R, Sharma, A, Noory, MA, Dinavahi, SS, Kardos, G, Drabick, JJ & Robertson, GP 2017, 'Improving pharmacological targeting of AKT in melanoma', Cancer Letters, vol. 404, pp. 29-36. https://doi.org/10.1016/j.canlet.2017.07.001
Teye, EK, Sido, A, Xin, P, Finnberg, NK, Gokare, P, Kawasawa, YI, Salzberg, AC, Shimko, S, Bayerl, M, Ehmann, WC, Claxton, DF, Rybka, WB, Drabick, JJ, Wang, HG, Abraham, T, El-Deiry, WS, Brodsky, RA, J.Hohl, R & Pu, JJ 2017, 'PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features', Oncotarget, vol. 8, no. 18, pp. 29887-29905. https://doi.org/10.18632/oncotarget.15136
Yin, M, Wang, W, Drabick, J & Harvey, H 2017, 'Prognosis and treatment of non-metastatic primary and secondary breast angiosarcoma: A comparative study', BMC Cancer, vol. 17, no. 1, 295. https://doi.org/10.1186/s12885-017-3292-7

2016

Matthew, EM, Zhou, L, Yang, Z, Dicker, DT, Holder, SL, Lim, B, Harouaka, R, Zheng, SY, Drabick, JJ, Lamparella, NE, Truica, CI & El-Deiry, WS 2016, 'A multiplexed marker-based algorithm for diagnosis of carcinoma of unknown primary using circulating tumor cells', Oncotarget, vol. 7, no. 4, pp. 3662-3676. https://doi.org/10.18632/oncotarget.6657
Baker, MJ, Goldstein, AM, Gordon, PL, Harbaugh, KS, Mackley, HB, Glantz, MJ & Drabick, JJ 2016, 'An interstitial deletion within 9p21.3 and extending beyond CDKN2A predisposes to melanoma, neural system tumours and possible haematological malignancies', Journal of medical genetics, vol. 53, no. 11, pp. 721-727. https://doi.org/10.1136/jmedgenet-2015-103446
Al-Marrawi, MY, Mackley, HB, Ali, S, Wagner, H, Joshi, M, Holder, S, Kaag, M, Mallon, C, Talamo, G & Drabick, JJ 2016, 'Consolidation With Radiation or Concurrent Chemo-Radiation After Chemotherapy Results in Durable Complete Remissions of Isolated Nodal Recurrences of Urothelial Cancer: A Case Series and Review', Clinical Genitourinary Cancer, vol. 14, no. 4, pp. e393-e399. https://doi.org/10.1016/j.clgc.2016.01.004
Koller, KM, Wang, W, Schell, T, Cozza, EM, Kokolus, KM, Neves, R, Mackley, H, Pameijer, CR, Leung, A, Anderson, B, Mallon, CA, Robertson, G & Drabick, J 2016, 'Malignant melanoma—The cradle of anti-neoplastic immunotherapy', Critical Reviews in Oncology/Hematology, vol. 106, pp. 25-54. https://doi.org/10.1016/j.critrevonc.2016.04.010
Joshi, M, Millis, SZ, Arguello, D, Holder, SL, Lamm, D, Reddy, S, Belani, C, Drabick, JJ & Vogelzang, NJ 2018, 'Molecular Characterization of Bladder Cancer in Smokers versus Nonsmokers', European Urology Focus, vol. 4, no. 1, pp. 94-97. https://doi.org/10.1016/j.euf.2016.06.011
Yin, M, Joshi, M, Meijer, RP, Glantz, M, Holder, S, Harvey, HA, Kaag, M, Van De Putte, EEF, Horenblas, S & Drabick, JJ 2016, 'Neoadjuvant chemotherapy for muscle-invasive bladder cancer: A systematic review and two-step meta-analysis', Oncologist, vol. 21, no. 6, pp. 708-715. https://doi.org/10.1634/theoncologist.2015-0440
Joshi, M, Pal, SK & Drabick, JJ 2016, 'Novel approaches in cancer immunotherapy - A light at the end of the tunnel', Discovery Medicine, vol. 21, no. 118.
Yin, M, MacKley, HB, Drabick, JJ & Harvey, HA 2016, 'Primary female breast sarcoma: Clinicopathological features, treatment and prognosis', Scientific reports, vol. 6, 31497. https://doi.org/10.1038/srep31497
Joshi, M, Vasekar, M, Grivas, P, Emamekhoo, H, Hsu, JA, Miller, VA, Stephens, PJ, Ali, SM, Ross, JS, Zhu, J, Warrick, J, Drabick, JJ, Holder, SL, Kaag, M, Li, M & Pal, SK 2016, 'Relationship of smoking status to genomic profile, chemotherapy response and clinical outcome in patients with advanced urothelial carcinoma', Oncotarget, vol. 7, no. 32, pp. 52442-52449. https://doi.org/10.18632/oncotarget.9449
Yin, M, Wang, W, Rosenberg, J, Kaag, MG, Joshi, M, Holder, S, Tuanquin, L & Drabick, J 2016, 'Targeted Therapy in Collecting Duct Carcinoma of the Kidney: A Case Report and Literature Review', Clinical Genitourinary Cancer, vol. 14, no. 2, pp. e203-e206. https://doi.org/10.1016/j.clgc.2015.11.008

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)