Researcher Profile

Researcher Profile

Brad Zacharia, MD, MS

Brad Zacharia, MD, MS

Assistant Professor, Department of Neurosurgery
Disease Teams:
Central Nervous System Cancer
buz6@psu.edu

Research Interests

  • Therapeutics
  • Neoplasms
  • Cerebral Hemorrhage
  • Stroke
  • Subarachnoid Hemorrhage
  • Intracranial Aneurysm
  • Astrocytoma
  • Incidence
  • Population
  • Wounds and Injuries
  • Brain Ischemia
  • Intracranial Vasospasm

Clinical Trials

A Phase 1b/2 study to assess the safety, tolerability and efficacy of BGB-290 in combination with radiation therapy and/or temozolomide in subjects with first-line or recurrent/refractory glioblastoma
A Multicenter Study of 5-Aminolevulinic Acid (5-ALA) to Enhance Visualization of Malignant Tumor in Patients With Newly Diagnosed or Recurrent Malignant Gliomas: A Safety, Histopathology, and Correlative Biomarker Study

Recent Publications

2019

Lee, JH, Ba, D, Liu, G, Leslie, D, Zacharia, B & Goyal, N 2019, 'Association of Head and Neck Cancer with Mental Health Disorders in a Large Insurance Claims Database', JAMA Otolaryngology - Head and Neck Surgery, vol. 145, no. 4, pp. 339-344. https://doi.org/10.1001/jamaoto.2018.4512
Wilson, MN, Nuss, DW, Zacharia, B & Snyderman, CH 2019, 'Surgical management of juvenile nasopharyngeal angiofibroma' Operative Techniques in Otolaryngology - Head and Neck Surgery, vol. 30, no. 1, pp. 22-29. https://doi.org/10.1016/j.otot.2019.01.007
Shokri, T, Zacharia, B & Lighthall, J 2019, 'Traumatic Orbital Apex Syndrome: An Uncommon Sequela of Facial Trauma', Ear, Nose and Throat Journal. https://doi.org/10.1177/0145561319860526

2018

Mrowczynski, OD, Zacharia, B & Connor, J 2019, 'Exosomes and their implications in central nervous system tumor biology', Progress in Neurobiology, vol. 172, pp. 71-83. https://doi.org/10.1016/j.pneurobio.2018.06.006
Mrowczynski, OD, Madhankumar, A, Sundstrom, J, Zhao, Y, Imamura, Y, Slagle-Webb, B, Mau, C, Payne, RA, Rizk, E, Zacharia, B & Connor, J 2018, 'Exosomes impact survival to radiation exposure in cell line models of nervous system cancer', Oncotarget, vol. 9, no. 90, pp. 36083-36101.
Davanzo, JR, Goyal, N & Zacharia, B 2018, 'Expanded Endoscopic Endonasal Resection of Retrochiasmatic Craniopharyngioma', Journal of Neurological Surgery, Part B: Skull Base, vol. 79, no. 2, pp. S194-S195. https://doi.org/10.1055/s-0038-1623524

2017

Sonabend, AM, Zacharia, B, Cloney, MB, Sonabend, A, Showers, C, Ebiana, V, Nazarian, M, Swanson, KR, Baldock, A, Brem, H, Bruce, JN, Butler, W, Cahill, DP, Carter, B, Orringer, DA, Roberts, DW, Sagher, O, Sanai, N, Schwartz, TH, Silbergeld, DL, Sisti, MB, Thompson, RC, Waziri, AE, Ghogawala, Z & McKhann, G 2017, 'Defining glioblastoma resectability through the wisdom of the crowd: A proof-of-principle study', Neurosurgery, vol. 80, no. 4, pp. 590-601. https://doi.org/10.1227/NEU.0000000000001374
Mrowczynski, OD, Madhankumar, A, Slagle-Webb, B, Lee, S, Zacharia, B & Connor, J 2017, 'HFE genotype affects exosome phenotype in cancer', Biochimica et Biophysica Acta - General Subjects, vol. 1861, no. 8, pp. 1921-1928. https://doi.org/10.1016/j.bbagen.2017.05.014
Zacharia, B, Kahn, S, Bander, ED, Cederquist, GY, Cope, WP, McLaughlin, L, Hijazi, A, Reiner, AS, Laufer, I & Bilsky, M 2017, 'Incidence and risk factors for preoperative deep venous thrombosis in 314 consecutive patients undergoing surgery for spinal metastasis', Journal of Neurosurgery: Spine, vol. 27, no. 2, pp. 189-197. https://doi.org/10.3171/2017.2.SPINE16861
Madhankumar, A, Mrowczynski, OD, Patel, SR, Weston, CL, Zacharia, B, Glantz, M, Siedlecki, C, Xu, L & Connor, J 2017, 'Interleukin-13 conjugated quantum dots for identification of glioma initiating cells and their extracellular vesicles', Acta Biomaterialia, vol. 58, pp. 205-213. https://doi.org/10.1016/j.actbio.2017.06.002
Zacharia, B, DiStefano, N, Mader, MM, Chohan, MO, Ogilvie, S, Brennan, C, Gutin, P & Tabar, V 2017, 'Prior malignancies in patients harboring glioblastoma: an institutional case-study of 2164 patients' Journal of neuro-oncology, vol. 134, no. 2, pp. 245-251. https://doi.org/10.1007/s11060-017-2512-y
Bernardo, A, Evins, AI, Mattogno, PP, Quiroga, M & Zacharia, B 2017, 'The Orbit as Seen Through Different Surgical Windows: Extensive Anatomosurgical Study', World Neurosurgery, vol. 106, pp. 1030-1046. https://doi.org/10.1016/j.wneu.2017.06.158
Zhang, C, Verma, V, Lyden, ER, Horowitz, DP, Zacharia, B, Lin, C & Connolly, EP 2018, 'The role of definitive radiotherapy in craniopharyngioma: A SEER analysis', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 41, no. 8, pp. 807-812. https://doi.org/10.1097/COC.0000000000000378

2016

Zacharia, B, Amine, M, Anand, V & Schwartz, TH 2016, 'Endoscopic Endonasal Management of Craniopharyngioma', Otolaryngologic Clinics of North America, vol. 49, no. 1, pp. 201-212. https://doi.org/10.1016/j.otc.2015.09.013
Cloney, M, D'Amico, R, Lebovic, J, Nazarian, M, Zacharia, B, Sisti, MB, Bruce, JN, McKhann, GM, Iwamoto, FM & Sonabend, AM 2016, 'Frailty in Geriatric Glioblastoma Patients: A Predictor of Operative Morbidity and Outcome', World neurosurgery, vol. 89, pp. 362-367. https://doi.org/10.1016/j.wneu.2015.12.096
Youngerman, BE, Zacharia, B, Hickman, ZL, Bruce, JN, Solomon, RA & Benzil, DL 2016, 'Making Milestones: Development and Implementation of a Formal Socioeconomic Curriculum in a Neurosurgical Residency Training Program', Neurosurgery, vol. 79, no. 3, pp. 492-497. https://doi.org/10.1227/NEU.0000000000001126
Zacharia, B, Youngerman, BE, Bruce, SS, Hershman, DL, Neugut, AI, Bruce, JN & Wright, JD 2017, 'Quality of postoperative venous thromboembolism prophylaxis in neuro-oncologic surgery', Neurosurgery, vol. 80, no. 1, pp. 73-81. https://doi.org/10.1227/NEU.0000000000001270
Brandmeir, NJ, McInerney, J & Zacharia, B 2016, 'The use of custom 3D printed stereotactic frames for laser interstitial thermal ablation: Technical note', Neurosurgical Focus, vol. 41, no. 4, E3. https://doi.org/10.3171/2016.8.FOCUS16219

2015

Praver, M, D'Amico, R, Arraez, C, Zacharia, B, Varma, H, Goldman, JE, Bruce, JN & Canoll, P 2015, 'Atypical pleomorphic neoplasms of the pineal gland: Case report and review of the literature' Surgical Neurology International, vol. 6, no. 1, 129. https://doi.org/10.4103/2152-7806.161790
Zacharia, B & Schwartz, TH 2015, 'Diffusion of neuroendoscopy: Guided by the light' World Neurosurgery, vol. 83, no. 5, pp. 752-753. https://doi.org/10.1016/j.wneu.2014.10.010
Zacharia, B, Romero, FR, Rapoport, SK, Raza, SM, Anand, VK & Schwartz, TH 2015, 'Endoscopic Endonasal Management of Metastatic Lesions of the Anterior Skull Base: Case Series and Literature Review' World Neurosurgery, vol. 84, no. 5, pp. 1267-1277. https://doi.org/10.1016/j.wneu.2015.05.061
Ducruet, AF, Grobelny, BT, Zacharia, B, Hickman, ZL, DeRosa, PL, Andersen, KN, Sussman, E, Carpenter, A & Connolly, ES 2015, 'Erratum: The surgical management of chronic subdural hematoma [Neurosurgical Review, 35, 2, (155-169), DOI 10.1007/s10143-011-0349-y]', Neurosurgical Review, vol. 38, no. 4. https://doi.org/10.1007/s10143-015-0644-0
Simon, S, Koyama, T, Zacharia, B, Schirmer, CM & Cheng, JS 2015, 'Impact of clinical trials on neurosurgical practice: An assessment of case volume' World Neurosurgery, vol. 83, no. 4, pp. 431-437. https://doi.org/10.1016/j.wneu.2015.01.011
D'Amico, RS, Cloney, MB, Sonabend, AM, Zacharia, B, Nazarian, MN, Iwamoto, FM, Sisti, MB, Bruce, JN & McKhann, GM 2015, 'The Safety of Surgery in Elderly Patients with Primary and Recurrent Glioblastoma', World neurosurgery, vol. 84, no. 4, pp. 913-919. https://doi.org/10.1016/j.wneu.2015.05.072

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)