Researcher Profile

Researcher Profile

Brad Zacharia, MD, MS

Brad Zacharia, MD, MS

Associate Professor, Department of Neurosurgery
Associate Professor, Department of Otolaryngology - Head and Neck Surgery
Disease Teams:
Brain and Central Nervous System Cancer
buz6@psu.edu

Research Interests

  • Therapeutics
  • Neoplasms
  • Cerebral Hemorrhage
  • Stroke
  • Subarachnoid Hemorrhage
  • Databases
  • Incidence
  • Cohort Studies
  • Astrocytoma
  • Intracranial Aneurysm
  • Population
  • Brain

Clinical Trials

A Phase 1b/2 study to assess the safety, tolerability and efficacy of BGB-290 in combination with radiation therapy and/or temozolomide in subjects with first-line or recurrent/refractory glioblastoma
3D-PREDICT Registry: 3D Prediction of patient-specific Response using ex vivo Interrogation of live cells from tumors

Recent Publications

2021

Daggubati, LC, Ryan, CA, Brandon, C, Madden, DB, Farou, N, Mansouri, A & Zacharia, BE 2021, '#Neurosurgery: A Temporal and Content Analysis of Academic Neurosurgery on Twitter', World neurosurgery, vol. 153, pp. e481-e487. https://doi.org/10.1016/j.wneu.2021.06.150
Khalafallah, AM, Rakovec, M, Bettegowda, C, Jackson, CM, Gallia, GL, Weingart, JD, Lim, M, Esquenazi, Y, Zacharia, BE, Goldschmidt, E, Ziu, M, Ivan, ME, Venteicher, AS, Nduom, EK, Mamelak, AN, Chu, RM, Yu, JS, Sheehan, JP, Nahed, BV, Carter, BS, Berger, MS, Sawaya, R & Mukherjee, D 2021, 'A crowdsourced consensus on supratotal resection versus gross total resection for anatomically distinct primary glioblastoma', Neurosurgery, vol. 89, no. 4, pp. 712-719. https://doi.org/10.1093/neuros/nyab257
Kanekar, S & Zacharia, BE 2021, 'Imaging Findings of New Entities and Patterns in Brain Tumor: Isocitrate Dehydrogenase Mutant, Isocitrate Dehydrogenase Wild-Type, Codeletion, and MGMT Methylation', Radiologic Clinics of North America, vol. 59, no. 3, pp. 305-322. https://doi.org/10.1016/j.rcl.2021.01.001
Maurer, R, McNutt, S, Daggubati, LC, Ba, DM, Liu, G, Leslie, D, Goyal, N & Zacharia, B 2021, 'Mental health disorders in newly diagnosed non-functional pitutary adenoma under initial observation: an observational cohort study using the nationwide MarketScan database', Pituitary. https://doi.org/10.1007/s11102-021-01172-1
Bunevicius, A, Suleiman, M, Patel, S, Álvarez, RM, Moreno, NEM, Liscak, R, Hanuska, J, Langlois, AM, Mathieu, D, Mau, C, Caldwell, C, Tuanquin, LC, Zacharia, BE, McInerney, J, Lee, CC, Yang, HC, Peterson, JL, Trifiletti, DM, Ogino, A, Kano, H, Warnick, RE, Saylany, A, Buch, LY, Lee, JYK, Strickland, BA, Zada, G, Chang, EL, Lunsford, LD & Sheehan, J 2021, 'Stereotactic radiosurgery for treatment of radiation-induced meningiomas: A multiinstitutional study', Journal of neurosurgery, vol. 135, no. 3, pp. 862-870. https://doi.org/10.3171/2020.7.JNS202064

2020

Karmur, BS, Philteos, J, Abbasian, A, Zacharia, BE, Lipsman, N, Levin, V, Grossman, S & Mansouri, A 2020, 'Blood-Brain Barrier Disruption in Neuro-Oncology: Strategies, Failures, and Challenges to Overcome', Frontiers in Oncology, vol. 10, 563840. https://doi.org/10.3389/fonc.2020.563840
Liaw, J, Patel, V, Bann, DV, Saadi, RA, Mau, C, Brettler, S, Tuanquin, L, Zacharia, BE & Isildak, H 2020, 'COVID-19 pandemic: Safety precautions for stereotactic radiosurgery', Neurosurgery, vol. 87, no. 2, pp. E201-E202. https://doi.org/10.1093/neuros/nyaa163
Mamourian, AC, Gopal, P, Davtyan, K, Kaiserian, M, Mamourian, EC & Zacharia, BE 2020, 'Calcifications of the Medial Choroid in the Velum Interpositum: An Unrecognized Site of Physiologic Calcifications Evident on Multidetector Computed Tomography', World neurosurgery, vol. 141, pp. e160-e165. https://doi.org/10.1016/j.wneu.2020.05.042
Bernstein, A, Mrowczynski, OD, Greene, A, Ryan, S, Chung, C, Zacharia, BE & Glantz, M 2020, 'Dual BRAF/MEK therapy in BRAF V600E-mutated primary brain tumors: A case series showing dramatic clinical and radiographic responses and a reduction in cutaneous toxicity', Journal of neurosurgery, vol. 133, no. 6, pp. 1704-1709. https://doi.org/10.3171/2019.8.JNS19643
Massaad, E, Hamidi, N, Goetz, J, Padmanaban, V, Mau, C, Tsang, D, de Moraes, FY, Chung, C, Zacharia, BE & Mansouri, A 2021, 'Equivalent Efficacy and Safety of Radiosurgery for Cystic and Solid Vestibular Schwannomas: A Systematic Review', World neurosurgery, vol. 146, pp. 322-331.e1. https://doi.org/10.1016/j.wneu.2020.11.040
Rusthoven, CG, Yamamoto, M, Bernhardt, D, Smith, DE, Gao, D, Serizawa, T, Yomo, S, Aiyama, H, Higuchi, Y, Shuto, T, Akabane, A, Sato, Y, Niranjan, A, Faramand, AM, Lunsford, LD, McInerney, J, Tuanquin, LC, Zacharia, BE, Chiang, V, Singh, C, Yu, JB, Braunstein, S, Mathieu, D, Touchette, CJ, Lee, CC, Yang, HC, Aizer, AA, Cagney, DN, Chan, MD, Kondziolka, D, Bernstein, K, Silverman, JS, Grills, IS, Siddiqui, ZA, Yuan, JC, Sheehan, JP, Cordeiro, D, Nosaki, K, Seto, T, Deibert, CP, Verma, V, Day, S, Halasz, LM, Warnick, RE, Trifiletti, DM, Palmer, JD, Attia, A, Li, B, Cifarelli, CP, Brown, PD, Vargo, JA, Combs, SE, Kessel, KA, Rieken, S, Patel, S, Guckenberger, M, Andratschke, N, Kavanagh, BD & Robin, TP 2020, 'Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases: The FIRE-SCLC Cohort Study', JAMA Oncology, vol. 6, no. 7, pp. 1028-1037. https://doi.org/10.1001/jamaoncol.2020.1271
Brar, K, Hachem, LD, Badhiwala, JH, Mau, C, Zacharia, BE, Moraes, FYD, Pirouzmand, F & Mansouri, A 2020, 'Management of Diffuse Low-Grade Glioma: The Renaissance of Robust Evidence', Frontiers in Oncology, vol. 10, 575658. https://doi.org/10.3389/fonc.2020.575658
Lee, JH, Zacharia, BE, Ba, D, Leslie, D, Liu, G & Goyal, N 2020, 'Mental Health Disorders Associated with Sinonasal and Skull Base Malignancies: A Large Cohort Study', Journal of Neurological Surgery, Part B: Skull Base, vol. 81, no. 2, pp. 187-192. https://doi.org/10.1055/s-0039-1679889
Maurer, R, Daggubati, L, Ba, DM, Liu, G, Leslie, D, Goyal, N & Zacharia, BE 2020, 'Mental health disorders in patients with untreated meningiomas: An observational cohort study using the nationwide marketscan database', Neuro-Oncology Practice, vol. 7, no. 5, pp. 507-513. https://doi.org/10.1093/nop/npaa025
Yee, PP, Wei, Y, Kim, SY, Lu, T, Chih, SY, Lawson, C, Tang, M, Liu, Z, Anderson, B, Thamburaj, K, Young, MM, Aregawi, DG, Glantz, MJ, Zacharia, BE, Specht, CS, Wang, HG & Li, W 2020, 'Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression', Nature communications, vol. 11, no. 1, 5424. https://doi.org/10.1038/s41467-020-19193-y
Zacharia, BE, Eichberg, DG, Ivan, ME, Hanft, S, Boockvar, JA, Isildak, H, Mansouri, A, Komotar, RJ & D’Amico, RS 2020, 'Surgical management of brain tumor patients in the COVID-19 era', Neurosurgery, vol. 87, no. 2, pp. E197-E200. https://doi.org/10.1093/neuros/nyaa162
Daggubati, LC, Eichberg, DG, Ivan, ME, Hanft, S, Mansouri, A, Komotar, RJ, D'Amico, RS & Zacharia, BE 2020, 'Telemedicine for Outpatient Neurosurgical Oncology Care: Lessons Learned for the Future During the COVID-19 Pandemic', World neurosurgery, vol. 139, pp. e859-e863. https://doi.org/10.1016/j.wneu.2020.05.140
Hung, YC, Lee, CC, Yang, HC, Mohammed, N, Kearns, KN, Nabeel, AM, Karim, KA, Emad Eldin, RM, El-Shehaby, AMN, Reda, WA, Tawadros, SR, Liscak, R, Jezkova, J, Lunsford, LD, Kano, H, Sisterson, ND, Álvarez, RM, Martínez Moreno, NE, Kondziolka, D, Golfinos, JG, Grills, I, Thompson, A, Borghei-Razavi, H, Maiti, TK, Barnett, GH, McInerney, J, Zacharia, BE, Xu, Z & Sheehan, JP 2020, 'The benefit and risk of stereotactic radiosurgery for prolactinomas: an international multicenter cohort study', Journal of neurosurgery, vol. 133, no. 3, pp. 717-726. https://doi.org/10.3171/2019.4.JNS183443

2019

Lee, JH, Ba, D, Liu, G, Leslie, D, Zacharia, B & Goyal, N 2019, 'Association of Head and Neck Cancer with Mental Health Disorders in a Large Insurance Claims Database', JAMA Otolaryngology - Head and Neck Surgery, vol. 145, no. 4, pp. 339-344. https://doi.org/10.1001/jamaoto.2018.4512
Gvozdjan, K, Zacharia, BE, Bayerl, MG, Tomi-Olugbodi, A, Boyer, C & Specht, CS 2019, 'Dural extranodal marginal zone lymphoma in an XRCC2 mutation carrier', Journal of neuropathology and experimental neurology, vol. 78, no. 12, pp. 1174-1177. https://doi.org/10.1093/jnen/nlz092
Lin, M, Bakhsheshian, J, Strickland, B, Rennert, RC, Chen, JW, Van Gompel, JJ, Young, RL, Kumar, PP, Coppens, J, Curry, WT, Zacharia, BE, Bailes, JE & Zada, G 2020, 'Navigable Channel-Based Trans-Sulcal Resection of Third Ventricular Colloid Cysts: A Multicenter Retrospective Case Series and Review of the Literature', World neurosurgery, vol. 133, pp. e702-e710. https://doi.org/10.1016/j.wneu.2019.09.134
Zaorsky, NG, Zhang, Y, Tchelebi, LT, Mackley, HB, Chinchilli, VM & Zacharia, BE 2019, 'Stroke among cancer patients', Nature communications, vol. 10, no. 1, 5172. https://doi.org/10.1038/s41467-019-13120-6
Wilson, MN, Nuss, DW, Zacharia, BE & Snyderman, CH 2019, 'Surgical management of juvenile nasopharyngeal angiofibroma', Operative Techniques in Otolaryngology - Head and Neck Surgery, vol. 30, no. 1, pp. 22-29. https://doi.org/10.1016/j.otot.2019.01.007
Shokri, T, Zacharia, BE & Lighthall, JG 2019, 'Traumatic Orbital Apex Syndrome: An Uncommon Sequela of Facial Trauma', Ear, Nose and Throat Journal, vol. 98, no. 10, pp. 609-612. https://doi.org/10.1177/0145561319860526

2018

Mrowczynski, OD, Zacharia, B & Connor, J 2019, 'Exosomes and their implications in central nervous system tumor biology', Progress in Neurobiology, vol. 172, pp. 71-83. https://doi.org/10.1016/j.pneurobio.2018.06.006
Mrowczynski, OD, Madhankumar, AB, Sundstrom, JM, Zhao, Y, Kawasawa, YI, Slagle-Webb, B, Mau, C, Payne, RA, Rizk, EB, Zacharia, BE & Connor, JR 2018, 'Exosomes impact survival to radiation exposure in cell line models of nervous system cancer', Oncotarget, vol. 9, no. 90, pp. 36083-36101. https://doi.org/10.18632/oncotarget.26300
Davanzo, JR, Goyal, N & Zacharia, BE 2018, 'Expanded Endoscopic Endonasal Resection of Retrochiasmatic Craniopharyngioma', Journal of Neurological Surgery, Part B: Skull Base, vol. 79, no. 2, pp. S194-S195. https://doi.org/10.1055/s-0038-1623524

2017

Sonabend, AM, Zacharia, BE, Cloney, MB, Sonabend, A, Showers, C, Ebiana, V, Nazarian, M, Swanson, KR, Baldock, A, Brem, H, Bruce, JN, Butler, W, Cahill, DP, Carter, B, Orringer, DA, Roberts, DW, Sagher, O, Sanai, N, Schwartz, TH, Silbergeld, DL, Sisti, MB, Thompson, RC, Waziri, AE, Ghogawala, Z & McKhann, G 2017, 'Defining glioblastoma resectability through the wisdom of the crowd: A proof-of-principle study', Neurosurgery, vol. 80, no. 4, pp. 590-601. https://doi.org/10.1227/NEU.0000000000001374
Mrowczynski, OD, Madhankumar, AB, Slagle-Webb, B, Lee, SY, Zacharia, BE & Connor, JR 2017, 'HFE genotype affects exosome phenotype in cancer', Biochimica et Biophysica Acta - General Subjects, vol. 1861, no. 8, pp. 1921-1928. https://doi.org/10.1016/j.bbagen.2017.05.014
Zacharia, BE, Kahn, S, Bander, ED, Cederquist, GY, Cope, WP, McLaughlin, L, Hijazi, A, Reiner, AS, Laufer, I & Bilsky, M 2017, 'Incidence and risk factors for preoperative deep venous thrombosis in 314 consecutive patients undergoing surgery for spinal metastasis', Journal of Neurosurgery: Spine, vol. 27, no. 2, pp. 189-197. https://doi.org/10.3171/2017.2.SPINE16861
Madhankumar, AB, Mrowczynski, OD, Patel, SR, Weston, CL, Zacharia, BE, Glantz, MJ, Siedlecki, CA, Xu, LC & Connor, JR 2017, 'Interleukin-13 conjugated quantum dots for identification of glioma initiating cells and their extracellular vesicles', Acta Biomaterialia, vol. 58, pp. 205-213. https://doi.org/10.1016/j.actbio.2017.06.002
Zacharia, BE, DiStefano, N, Mader, MM, Chohan, MO, Ogilvie, S, Brennan, C, Gutin, P & Tabar, V 2017, 'Prior malignancies in patients harboring glioblastoma: an institutional case-study of 2164 patients', Journal of neuro-oncology, vol. 134, no. 2, pp. 245-251. https://doi.org/10.1007/s11060-017-2512-y
Bernardo, A, Evins, AI, Mattogno, PP, Quiroga, M & Zacharia, BE 2017, 'The Orbit as Seen Through Different Surgical Windows: Extensive Anatomosurgical Study', World neurosurgery, vol. 106, pp. 1030-1046. https://doi.org/10.1016/j.wneu.2017.06.158
Zhang, C, Verma, V, Lyden, ER, Horowitz, DP, Zacharia, BE, Lin, C & Connolly, EP 2018, 'The role of definitive radiotherapy in craniopharyngioma: A SEER analysis', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 41, no. 8, pp. 807-812. https://doi.org/10.1097/COC.0000000000000378

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)