Researcher Profile

Researcher Profile

Brad Zacharia, MD, MS

Brad Zacharia, MD, MS

Assistant Professor, Department of Neurosurgery
Disease Teams:
Central Nervous System Cancer

Research Interests

  • Therapeutics
  • Neoplasms
  • Cerebral Hemorrhage
  • Stroke
  • Subarachnoid Hemorrhage
  • Intracranial Aneurysm
  • Astrocytoma
  • Incidence
  • Population
  • Wounds and Injuries
  • Brain Ischemia
  • Intracranial Vasospasm

Clinical Trials

A Phase 1b/2 study to assess the safety, tolerability and efficacy of BGB-290 in combination with radiation therapy and/or temozolomide in subjects with first-line or recurrent/refractory glioblastoma
A Multicenter Study of 5-Aminolevulinic Acid (5-ALA) to Enhance Visualization of Malignant Tumor in Patients With Newly Diagnosed or Recurrent Malignant Gliomas: A Safety, Histopathology, and Correlative Biomarker Study

Recent Publications


Lee, JH, Ba, D, Liu, G, Leslie, D, Zacharia, B & Goyal, N 2019, 'Association of Head and Neck Cancer with Mental Health Disorders in a Large Insurance Claims Database', JAMA Otolaryngology - Head and Neck Surgery, vol. 145, no. 4, pp. 339-344.
Wilson, MN, Nuss, DW, Zacharia, B & Snyderman, CH 2019, 'Surgical management of juvenile nasopharyngeal angiofibroma' Operative Techniques in Otolaryngology - Head and Neck Surgery, vol. 30, no. 1, pp. 22-29.
Shokri, T, Zacharia, B & Lighthall, J 2019, 'Traumatic Orbital Apex Syndrome: An Uncommon Sequela of Facial Trauma', Ear, Nose and Throat Journal.


Mrowczynski, OD, Zacharia, B & Connor, J 2019, 'Exosomes and their implications in central nervous system tumor biology', Progress in Neurobiology, vol. 172, pp. 71-83.
Mrowczynski, OD, Madhankumar, A, Sundstrom, J, Zhao, Y, Imamura, Y, Slagle-Webb, B, Mau, C, Payne, RA, Rizk, E, Zacharia, B & Connor, J 2018, 'Exosomes impact survival to radiation exposure in cell line models of nervous system cancer', Oncotarget, vol. 9, no. 90, pp. 36083-36101.
Davanzo, JR, Goyal, N & Zacharia, B 2018, 'Expanded Endoscopic Endonasal Resection of Retrochiasmatic Craniopharyngioma', Journal of Neurological Surgery, Part B: Skull Base, vol. 79, no. 2, pp. S194-S195.


Sonabend, AM, Zacharia, B, Cloney, MB, Sonabend, A, Showers, C, Ebiana, V, Nazarian, M, Swanson, KR, Baldock, A, Brem, H, Bruce, JN, Butler, W, Cahill, DP, Carter, B, Orringer, DA, Roberts, DW, Sagher, O, Sanai, N, Schwartz, TH, Silbergeld, DL, Sisti, MB, Thompson, RC, Waziri, AE, Ghogawala, Z & McKhann, G 2017, 'Defining glioblastoma resectability through the wisdom of the crowd: A proof-of-principle study', Neurosurgery, vol. 80, no. 4, pp. 590-601.
Mrowczynski, OD, Madhankumar, A, Slagle-Webb, B, Lee, S, Zacharia, B & Connor, J 2017, 'HFE genotype affects exosome phenotype in cancer', Biochimica et Biophysica Acta - General Subjects, vol. 1861, no. 8, pp. 1921-1928.
Zacharia, B, Kahn, S, Bander, ED, Cederquist, GY, Cope, WP, McLaughlin, L, Hijazi, A, Reiner, AS, Laufer, I & Bilsky, M 2017, 'Incidence and risk factors for preoperative deep venous thrombosis in 314 consecutive patients undergoing surgery for spinal metastasis', Journal of Neurosurgery: Spine, vol. 27, no. 2, pp. 189-197.
Madhankumar, A, Mrowczynski, OD, Patel, SR, Weston, CL, Zacharia, B, Glantz, M, Siedlecki, C, Xu, L & Connor, J 2017, 'Interleukin-13 conjugated quantum dots for identification of glioma initiating cells and their extracellular vesicles', Acta Biomaterialia, vol. 58, pp. 205-213.
Zacharia, B, DiStefano, N, Mader, MM, Chohan, MO, Ogilvie, S, Brennan, C, Gutin, P & Tabar, V 2017, 'Prior malignancies in patients harboring glioblastoma: an institutional case-study of 2164 patients' Journal of neuro-oncology, vol. 134, no. 2, pp. 245-251.
Bernardo, A, Evins, AI, Mattogno, PP, Quiroga, M & Zacharia, B 2017, 'The Orbit as Seen Through Different Surgical Windows: Extensive Anatomosurgical Study', World Neurosurgery, vol. 106, pp. 1030-1046.
Zhang, C, Verma, V, Lyden, ER, Horowitz, DP, Zacharia, B, Lin, C & Connolly, EP 2018, 'The role of definitive radiotherapy in craniopharyngioma: A SEER analysis', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 41, no. 8, pp. 807-812.


Zacharia, B, Amine, M, Anand, V & Schwartz, TH 2016, 'Endoscopic Endonasal Management of Craniopharyngioma', Otolaryngologic Clinics of North America, vol. 49, no. 1, pp. 201-212.
Cloney, M, D'Amico, R, Lebovic, J, Nazarian, M, Zacharia, B, Sisti, MB, Bruce, JN, McKhann, GM, Iwamoto, FM & Sonabend, AM 2016, 'Frailty in Geriatric Glioblastoma Patients: A Predictor of Operative Morbidity and Outcome', World neurosurgery, vol. 89, pp. 362-367.
Youngerman, BE, Zacharia, B, Hickman, ZL, Bruce, JN, Solomon, RA & Benzil, DL 2016, 'Making Milestones: Development and Implementation of a Formal Socioeconomic Curriculum in a Neurosurgical Residency Training Program', Neurosurgery, vol. 79, no. 3, pp. 492-497.
Zacharia, B, Youngerman, BE, Bruce, SS, Hershman, DL, Neugut, AI, Bruce, JN & Wright, JD 2017, 'Quality of postoperative venous thromboembolism prophylaxis in neuro-oncologic surgery', Neurosurgery, vol. 80, no. 1, pp. 73-81.
Brandmeir, NJ, McInerney, J & Zacharia, B 2016, 'The use of custom 3D printed stereotactic frames for laser interstitial thermal ablation: Technical note', Neurosurgical Focus, vol. 41, no. 4, E3.


Praver, M, D'Amico, R, Arraez, C, Zacharia, B, Varma, H, Goldman, JE, Bruce, JN & Canoll, P 2015, 'Atypical pleomorphic neoplasms of the pineal gland: Case report and review of the literature' Surgical Neurology International, vol. 6, no. 1, 129.
Zacharia, B & Schwartz, TH 2015, 'Diffusion of neuroendoscopy: Guided by the light' World Neurosurgery, vol. 83, no. 5, pp. 752-753.
Zacharia, B, Romero, FR, Rapoport, SK, Raza, SM, Anand, VK & Schwartz, TH 2015, 'Endoscopic Endonasal Management of Metastatic Lesions of the Anterior Skull Base: Case Series and Literature Review' World Neurosurgery, vol. 84, no. 5, pp. 1267-1277.
Ducruet, AF, Grobelny, BT, Zacharia, B, Hickman, ZL, DeRosa, PL, Andersen, KN, Sussman, E, Carpenter, A & Connolly, ES 2015, 'Erratum: The surgical management of chronic subdural hematoma [Neurosurgical Review, 35, 2, (155-169), DOI 10.1007/s10143-011-0349-y]', Neurosurgical Review, vol. 38, no. 4.
Simon, S, Koyama, T, Zacharia, B, Schirmer, CM & Cheng, JS 2015, 'Impact of clinical trials on neurosurgical practice: An assessment of case volume' World Neurosurgery, vol. 83, no. 4, pp. 431-437.
D'Amico, RS, Cloney, MB, Sonabend, AM, Zacharia, B, Nazarian, MN, Iwamoto, FM, Sisti, MB, Bruce, JN & McKhann, GM 2015, 'The Safety of Surgery in Elderly Patients with Primary and Recurrent Glioblastoma', World neurosurgery, vol. 84, no. 4, pp. 913-919.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)