Researcher Profile

Researcher Profile

Mitchell Machtay, MD

Mitchell Machtay, MD

Associate Dean for Clinical Cancer Research, Penn State College of Medicine
Professor, Department of Radiation Oncology
Professor, Department of Medicine
mzm6940@psu.edu

Research Interests

  • Radiotherapy
  • Therapeutics
  • Non-Small Cell Lung Carcinoma
  • Neoplasms
  • Survival
  • Head and Neck Neoplasms
  • Radiation Oncology
  • Radiation
  • Radiosurgery
  • Neoplasm Metastasis
  • Drug Therapy
  • Squamous Cell Carcinoma of Head and Neck

Recent Publications

2021

Grubb, WR, Ponsky, L, Lo, SS, Kharouta, M, Traughber, B, Sandstrom, K, MacLennan, GT, Shankar, E, Gupta, S, Machtay, M & Ellis, RJ 2021, 'Final results of a dose escalation protocol of stereotactic body radiotherapy for poor surgical candidates with localized renal cell carcinoma', Radiotherapy and Oncology, vol. 155, pp. 138-143. https://doi.org/10.1016/j.radonc.2020.10.031

2020

Jin, JY, Mereniuk, T, Yalamanchali, A, Wang, W, Machtay, M, (Spring)Kong, FM & Ellsworth, S 2020, 'A framework for modeling radiation induced lymphopenia in radiotherapy', Radiotherapy and Oncology, vol. 144, pp. 105-113. https://doi.org/10.1016/j.radonc.2019.11.014
Wang, W, Huang, L, Jin, JY, Pi, W, Ellsworth, SG, Jolly, S, Mellor, AL, Machtay, M & Kong, FM 2020, 'A validation study on IDO immune biomarkers for survival prediction in non–small cell lung cancer: Radiation dose fractionation effect in early-stage disease', Clinical Cancer Research, vol. 26, no. 1, pp. 282-289. https://doi.org/10.1158/1078-0432.CCR-19-1202
Rogers, LR, Ostrom, QT, Schroer, J, Vengoechea, J, Li, L, Gerson, S, Nock, CJ, Machtay, M, Selman, W, Lo, S, Sloan, AE & Barnholtz-Sloan, JS 2020, 'Association of metabolic syndrome with glioblastoma: A retrospective cohort study and review', Neuro-Oncology Practice, vol. 7, no. 5, pp. 541-548. https://doi.org/10.1093/nop/npaa011
Wang, W, Matuszak, MM, Hu, C, Huang, KC, Chen, E, Arenberg, D, Curtis, JL, Jolly, S, Jin, JY, Machtay, M, Ten Haken, RK & Kong, FMS 2020, 'Central Airway Toxicity After High Dose Radiation: A Combined Analysis of Prospective Clinical Trials for Non-Small Cell Lung Cancer', International Journal of Radiation Oncology Biology Physics, vol. 108, no. 3, pp. 587-596. https://doi.org/10.1016/j.ijrobp.2020.05.026
Sohn, JW, Kim, H, Park, SB, Lee, S, Monroe, JI, Malone, TB, Kinsella, T, Yao, M, Kunos, C, Lo, SS, Shenk, R & Machtay, M 2020, 'Clinical Study of Using Biometrics to Identify Patient and Procedure', Frontiers in Oncology, vol. 10, 586232. https://doi.org/10.3389/fonc.2020.586232
Worrell, SG, Towe, CW, A. Dorth, J, Machtay, M, Perry, Y & Linden, PA 2020, 'Higher Doses of Neoadjuvant Radiation for Esophageal Cancer Do Not Affect the Pathologic Complete Response Rate or Survival: A Propensity-Matched Analysis', Annals of Surgical Oncology, vol. 27, no. 2, pp. 500-508. https://doi.org/10.1245/s10434-019-07849-z
Eitz, KA, Lo, SS, Soliman, H, Sahgal, A, Theriault, A, Pinkham, MB, Foote, MC, Song, AJ, Shi, W, Redmond, KJ, Gui, C, Kumar, AMS, Machtay, M, Meyer, B & Combs, SE 2020, 'Multi-institutional analysis of prognostic factors and outcomes after hypofractionated stereotactic radiotherapy to the resection cavity in patients with brain metastases', JAMA Oncology. https://doi.org/10.1001/jamaoncol.2020.4630
Gensheimer, MF, Yom, SS, Soto, N, Dignam, JJ, Le, QT, Machtay, M & Curran, WJ 2020, 'Multicenter Clinical Cancer Research After COVID-19: A Perspective From NRG Oncology', International Journal of Radiation Oncology Biology Physics, vol. 108, no. 2, pp. 483-485. https://doi.org/10.1016/j.ijrobp.2020.06.056
Jin, JY, Gu, A, Wang, W, Oleinick, NL, Machtay, M & (Spring) Kong, FM 2020, 'Ultra-high dose rate effect on circulating immune cells: A potential mechanism for FLASH effect?', Radiotherapy and Oncology, vol. 149, pp. 55-62. https://doi.org/10.1016/j.radonc.2020.04.054

2019

Chen, X, Zheng, Y, Tatsuoka, C, Muzic, RF, Okoye, CC, O'Donnell, JK, Zidar, D, Avril, N, Oliveira, GH, Liu, H, Bucher, J, Machtay, M, Yao, M & Dorth, JA 2019, 'Chemoradiotherapy-related carotid artery inflammation in head and neck cancer patients quantified by [18F]FDG PET/CT', Oral Oncology, vol. 93, pp. 101-106. https://doi.org/10.1016/j.oraloncology.2019.04.008
Fredman, ET, Traughber, BJ, Gross, A, Podder, T, Colussi, V, Vinkler, R, Machtay, M & Ellis, RJ 2019, 'Comparison of multiparametric MRI-based and transrectal ultrasound-based preplans with intraoperative ultrasound-based planning for low dose rate interstitial prostate seed implantation', Journal of applied clinical medical physics, vol. 20, no. 6, pp. 31-38. https://doi.org/10.1002/acm2.12592
Grubb, WR, Machtay, M, Dowlati, A & Biswas, T 2019, 'Diffuse Atypical Cystic Brain Metastases in ALK+ NSCLC Treated With Whole Brain Radiation and Second-Generation ALK-Targeted Therapy', Practical Radiation Oncology, vol. 9, no. 2, pp. e129-e133. https://doi.org/10.1016/j.prro.2018.11.002
Hayman, JA, Dekker, A, Feng, M, Keole, SR, McNutt, TR, Machtay, M, Martin, NE, Mayo, CS, Pawlicki, T, Smith, BD, Kudner, R, Dawes, S & Yu, JB 2019, 'Minimum Data Elements for Radiation Oncology: An American Society for Radiation Oncology Consensus Paper', Practical Radiation Oncology, vol. 9, no. 6, pp. 395-401. https://doi.org/10.1016/j.prro.2019.07.017
Li, Y, Awan, MJ, Chang, T, Lavertu, P, Zender, C, Rezaee, R, Fowler, N, Wasman, J, Avril, NE, Chen, N, Machtay, M & Yao, M 2019, 'Post-radiotherapy PET/CT for predicting treatment outcomes in head and neck cancer after postoperative radiotherapy', European Journal of Nuclear Medicine and Molecular Imaging, vol. 46, no. 4, pp. 794-800. https://doi.org/10.1007/s00259-019-4272-8
Bovi, JA, Pugh, SL, Sabsevitz, D, Robinson, CG, Paulson, E, Mehta, MP, Gondi, V, Kundapur, V, Shahin, MS, Chao, ST, Machtay, M, DeNittis, AS, Laack, NN, Greenspoon, JN, Moore, KN, Huang, J, Dominello, MM & Kachnic, LA 2019, 'Pretreatment Volume of MRI-Determined White Matter Injury Predicts Neurocognitive Decline After Hippocampal Avoidant Whole-Brain Radiation Therapy for Brain Metastases: Secondary Analysis of NRG Oncology Radiation Therapy Oncology Group 0933', Advances in Radiation Oncology, vol. 4, no. 4, pp. 579-586. https://doi.org/10.1016/j.adro.2019.07.006

2018

Fredman, E, Traughber, B, Podder, T, Colussi, V, Zheng, Y, Russo, S, Herrmann, K, Paspulati, R, Waggoner, S, Zanotti, K, Nagel, C, Nakayama, J, Machtay, M & Ellis, RJ 2018, '3T multiparametric MRI–guided high-dose-rate combined intracavitary and interstitial adaptive brachytherapy for the treatment of cervical cancer with a novel split-ring applicator', Brachytherapy, vol. 17, no. 2, pp. 334-344. https://doi.org/10.1016/j.brachy.2017.09.007
Vargo, JA, Ward, MC, Caudell, JJ, Riaz, N, Dunlap, NE, Isrow, D, Zakem, SJ, Dault, J, Awan, MJ, Higgins, KA, Hassanadeh, C, Beitler, JJ, Reddy, CA, Marcrom, S, Boggs, DH, Bonner, JA, Yao, M, Machtay, M, Siddiqui, F, Trotti, AM, Lee, NY, Koyfman, SA, Ferris, RL & Heron, DE 2018, 'A Multi-institutional Comparison of SBRT and IMRT for Definitive Reirradiation of Recurrent or Second Primary Head and Neck Cancer', International Journal of Radiation Oncology Biology Physics, vol. 100, no. 3, pp. 595-605. https://doi.org/10.1016/j.ijrobp.2017.04.017
Baydoun, A, Vapiwala, N, Ponsky, LE, Awan, M, Kassaee, A, Sutton, D, Podder, TK, Zhang, Y, Dobbins, D, Muzic, RF, Traughber, B, Machtay, M & Ellis, R 2018, 'Comparative analysis for renal stereotactic body radiotherapy using Cyberknife, VMAT and proton therapy based treatment planning', Journal of applied clinical medical physics, vol. 19, no. 3, pp. 125-130. https://doi.org/10.1002/acm2.12308
Frank, SJ, Blanchard, P, Lee, JJ, Sturgis, EM, Kies, MS, Machtay, M, Vikram, B, Garden, AS, Rosenthal, DI, Gunn, GB, Fuller, CD, Hutcheson, K, Lai, S, Busse, PM, Lee, NY, Lin, A & Foote, RL 2018, 'Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation', Seminars in Radiation Oncology, vol. 28, no. 2, pp. 108-113. https://doi.org/10.1016/j.semradonc.2017.12.002
Ahn, PH, Machtay, M, Anne, PR, Cognetti, D, Keane, WM, Wuthrick, E, Dicker, AP & Axelrod, RS 2018, 'Phase i Trial Using Induction Ciplatin, Docetaxel, 5-FU and Erlotinib Followed by Cisplatin, Bevacizumab and Erlotinib with Concurrent Radiotherapy for Advanced Head and Neck Cancer', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 41, no. 5, pp. 441-446. https://doi.org/10.1097/COC.0000000000000317
Kumar, AMS, Miller, J, Hoffer, SA, Mansur, DB, Coffey, M, Lo, SS, Sloan, AE & Machtay, M 2018, 'Postoperative hypofractionated stereotactic brain radiation (HSRT) for resected brain metastases: improved local control with higher BED 10', Journal of neuro-oncology, vol. 139, no. 2, pp. 449-454. https://doi.org/10.1007/s11060-018-2885-6
Multi-Institution Reirradiation (MIRI) Collaborative 2018, 'Refining Patient Selection for Reirradiation of Head and Neck Squamous Carcinoma in the IMRT Era: A Multi-institution Cohort Study by the MIRI Collaborative', International Journal of Radiation Oncology Biology Physics, vol. 100, no. 3, pp. 586-594. https://doi.org/10.1016/j.ijrobp.2017.06.012
Yuan, J, Ellis, R & Machtay, M 2018, 'Technical Note: An approach to building a Monte Carlo simulation model for a double scattering proton beam system', Medical Physics, vol. 45, no. 6, pp. 2660-2666. https://doi.org/10.1002/mp.12895
Multi-Institution Reirradiation (MIRI) Collaborative 2018, 'Volume, Dose, and Fractionation Considerations for IMRT-based Reirradiation in Head and Neck Cancer: A Multi-institution Analysis', International Journal of Radiation Oncology Biology Physics, vol. 100, no. 3, pp. 606-617. https://doi.org/10.1016/j.ijrobp.2017.11.036

2017

Yuan, J & Machtay, M 2017, 'A Monte Carlo model and its commissioning for the Leksell Gamma Knife Perfexion radiosurgery system', Medical Physics, vol. 44, no. 9, pp. 4910-4918. https://doi.org/10.1002/mp.12402
Gittleman, H, Lim, D, Kattan, MW, Chakravarti, A, Gilbert, MR, Lassman, AB, Lo, SS, MacHtay, M, Sloan, AE, Sulman, EP, Tian, D, Vogelbaum, MA, Wang, TJC, Penas-Prado, M, Youssef, E, Blumenthal, DT, Zhang, P, Mehta, MP & Barnholtz-Sloan, JS 2017, 'An independently validated nomogram for individualized estimation of survival among patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825', Neuro-oncology, vol. 19, no. 5, pp. 669-677. https://doi.org/10.1093/neuonc/now208
Okoye, CC, Bucher, J, Tatsuoka, C, Parikh, SA, Oliveira, GH, Gibson, MK, Machtay, M, Yao, M, Zender, CA & Dorth, JA 2017, 'Cardiovascular risk and prevention in patients with head and neck cancer treated with radiotherapy', Head and Neck, vol. 39, no. 3, pp. 527-532. https://doi.org/10.1002/hed.24646
Awan, MJ, Dorth, J, Mani, A, Kim, H, Zheng, Y, Mislmani, M, Welford, S, Yuan, J, Wessels, BW, Lo, SS, Letterio, J, Machtay, M, Sloan, A & Sohn, JW 2017, 'Development and Validation of a Small Animal Immobilizer and Positioning System for the Study of Delivery of Intracranial and Extracranial Radiotherapy Using the Gamma Knife System', Technology in Cancer Research and Treatment, vol. 16, no. 2, pp. 203-210. https://doi.org/10.1177/1533034616658394
Bazan, JG, Duan, F, Snyder, BS, Horng, D, Graves, EE, Siegel, BA, Machtay, M & Loo, BW 2017, 'Metabolic tumor volume predicts overall survival and local control in patients with stage III non-small cell lung cancer treated in ACRIN 6668/RTOG 0235', European Journal of Nuclear Medicine and Molecular Imaging, vol. 44, no. 1, pp. 17-24. https://doi.org/10.1007/s00259-016-3520-4
Salavati, A, Duan, F, Snyder, BS, Wei, B, Houshmand, S, Khiewvan, B, Opanowski, A, Simone, CB, Siegel, BA, Machtay, M & Alavi, A 2017, 'Optimal FDG PET/CT volumetric parameters for risk stratification in patients with locally advanced non-small cell lung cancer: results from the ACRIN 6668/RTOG 0235 trial', European Journal of Nuclear Medicine and Molecular Imaging, vol. 44, no. 12, pp. 1969-1983. https://doi.org/10.1007/s00259-017-3753-x
Baydoun, A, Traughber, B, Morris, N, Abi Zeid Daou, M, McGraw, M, Podder, TK, Muzic, RF, Lo, SS, Ponsky, LE, MacHtay, M & Ellis, R 2017, 'Outcomes and toxicities in patients treated with definitive focal therapy for primary prostate cancer: Systematic review', Future Oncology, vol. 13, no. 7, pp. 649-663. https://doi.org/10.2217/fon-2016-0354
Awan, MJ, Lavertu, P, Zender, C, Rezaee, R, Fowler, N, Karapetyan, L, Gibson, M, Wasman, J, Faulhaber, P, Machtay, M & Yao, M 2017, 'Post-treatment PET/CT and p16 status for predicting treatment outcomes in locally advanced head and neck cancer after definitive radiation', European Journal of Nuclear Medicine and Molecular Imaging, vol. 44, no. 6, pp. 988-997. https://doi.org/10.1007/s00259-016-3612-1
Kong, FMS, Hirsch, FR & Machtay, M 2017, 'Potential future consideration for imaging and blood-based biomarkers for precision medicine in lung cancer', Translational Lung Cancer Research, vol. 6, no. 6, pp. 713-715. https://doi.org/10.21037/tlcr.2017.09.11
Kang, KH, Efird, JT, Sharma, N, Yang, M, Dowlati, A, Linden, P, MacHtay, M & Biswas, T 2017, 'Prognostic potential of neutrophil-to-lymphocyte ratio and lymphocyte nadir in stage III non-small-cell lung cancer', Future Oncology, vol. 13, no. 16, 0045. https://doi.org/10.2217/fon-2017-0045

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