Researcher Profile

Researcher Profile

Mitchell Machtay, MD

Mitchell Machtay, MD

Associate Dean for Clinical Cancer Research, Penn State College of Medicine
Professor, Department of Radiation Oncology
Professor, Department of Medicine
Scientific Program:Next-Generation Therapies
Disease Teams:
Brain and Central Nervous System Cancer
Head and Neck Cancer
Thoracic Cancer

Research Interests

  • Radiotherapy
  • Therapeutics
  • Non-Small Cell Lung Carcinoma
  • Survival
  • Neoplasms
  • Head and Neck Neoplasms
  • Radiation Oncology
  • Radiation
  • Radiosurgery
  • Neoplasm Metastasis
  • Drug Therapy
  • Squamous Cell Carcinoma of Head and Neck

Clinical Trials

A Phase 3, Randomized, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Stereotactic Body Radiotherapy (SBRT) with or without Pembrolizumab (MK-3475) in Participants with Medically Inoperable Stages I or IIA Non Small Cell Lung Cancer (NSCLC)(KEYNOTE-867) MK 3475-867
A Phase III Study of Pembrolizumab (MK-3475) in Combination with Concurrent Chemoradiation Therapy Followed by Pembrolizumab with or without Olaparib, Compared to Concurrent Chemoradiation Therapy Followed by Placebo in Participants with Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) (MK7339-013)
NCI COVID-19 in Cancer Patients Study (N-CCaPS): A Longitudinal Natural History Study
S1827 A randomized Phase III trial comparing prophylactic cranial irradiation (PCI) for any patient with small cell lung cancer (either extensive or limited stage) to active surveillance with MRI in place of PCI
Randomized Phase II/III Trial of Adjuvant Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck
A Randomized Phase II Trial of Salvage Radiotherapy with Standard vs Enhanced Androgen Deprivation Therapy (with Enzalutamide) in Patients with Post-Prostatectomy PSA Recurrences with Aggressive Disease Features RTOG 3506, STEEL
NRG-LU007 Randomized Phase II/III Trial Of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR trial
Maintenance Systemic Therapy Versus Local Consolidative Therapy (LCT) Plus Maintenance Systemic Therapy for Limited Metastatic Non-Small Cell Lung Cancer (NSCLC): A Randomized Phase II/III Trial
Randomized Phase III Trial of MEDI4736 (durvalumab) as Concurrent and Consolidative Therapy or Consolidative Therapy Alone for Unresectable Stage 3 NSCLC

Recent Publications


Kang, KH, Efird, JT, Podder, TK, Zhang, Y, Dowlati, A, Machtay, M, Jindal, C & Biswas, T 2021, 'A pilot study examining the prognostic utility of tumor shrinkage on cone-beam computed tomography (Cbct) for stage iii locally advanced non-small cell lung cancer patients treated with definitive chemoradiation', International journal of environmental research and public health, vol. 18, no. 6, 3241, pp. 1-8.
Grubb, WR, Ponsky, L, Lo, SS, Kharouta, M, Traughber, B, Sandstrom, K, MacLennan, GT, Shankar, E, Gupta, S, Machtay, M & Ellis, RJ 2021, 'Final results of a dose escalation protocol of stereotactic body radiotherapy for poor surgical candidates with localized renal cell carcinoma', Radiotherapy and Oncology, vol. 155, pp. 138-143.
Yu, Y, Fu, P, Jin, JY, Gao, S, Wang, W, Machtay, M, Wang, L, Kong, FMS & Yu, J 2021, 'Impact of effective dose to immune cells (EDIC) on lymphocyte nadir and survival in limited-stage SCLC', Radiotherapy and Oncology, vol. 162, pp. 26-33.
Awan, MJ, Gittleman, H, Barnholtz-Sloan, J, Machtay, M, Nguyen-Tan, PF, Rosenthal, DI, Schultz, C, Huth, BJ, Thorstad, WL, Frank, SJ, Kim, H, Foote, RL, Lango, MN, Shenouda, G, Suntharalingam, M, Harris, J, Zhang, Q, Le, QT & Yao, M 2021, 'Risk groups of laryngeal cancer treated with chemoradiation according to nomogram scores – A pooled analysis of RTOG 0129 and 0522', Oral Oncology, vol. 116, 105241.
Sheikh, S, Dey, A, Datta, S, Podder, TK, Jindal, C, Dowlati, A, Efird, JT, Machtay, M & Biswas, T 2021, 'Role of radiation in extensive stage small cell lung cancer: A National Cancer Database registry analysis', Future Oncology, vol. 17, no. 21, pp. 2713-2724.


Jin, JY, Mereniuk, T, Yalamanchali, A, Wang, W, Machtay, M, (Spring)Kong, FM & Ellsworth, S 2020, 'A framework for modeling radiation induced lymphopenia in radiotherapy', Radiotherapy and Oncology, vol. 144, pp. 105-113.
Wang, W, Huang, L, Jin, JY, Pi, W, Ellsworth, SG, Jolly, S, Mellor, AL, Machtay, M & Kong, FM 2020, 'A validation study on IDO immune biomarkers for survival prediction in non–small cell lung cancer: Radiation dose fractionation effect in early-stage disease', Clinical Cancer Research, vol. 26, no. 1, pp. 282-289.
Rogers, LR, Ostrom, QT, Schroer, J, Vengoechea, J, Li, L, Gerson, S, Nock, CJ, Machtay, M, Selman, W, Lo, S, Sloan, AE & Barnholtz-Sloan, JS 2020, 'Association of metabolic syndrome with glioblastoma: A retrospective cohort study and review', Neuro-Oncology Practice, vol. 7, no. 5, pp. 541-548.
Wang, W, Matuszak, MM, Hu, C, Huang, KC, Chen, E, Arenberg, D, Curtis, JL, Jolly, S, Jin, JY, Machtay, M, Ten Haken, RK & Kong, FMS 2020, 'Central Airway Toxicity After High Dose Radiation: A Combined Analysis of Prospective Clinical Trials for Non-Small Cell Lung Cancer', International Journal of Radiation Oncology Biology Physics, vol. 108, no. 3, pp. 587-596.
Sohn, JW, Kim, H, Park, SB, Lee, S, Monroe, JI, Malone, TB, Kinsella, T, Yao, M, Kunos, C, Lo, SS, Shenk, R & Machtay, M 2020, 'Clinical Study of Using Biometrics to Identify Patient and Procedure', Frontiers in Oncology, vol. 10, 586232.
Worrell, SG, Towe, CW, A. Dorth, J, Machtay, M, Perry, Y & Linden, PA 2020, 'Higher Doses of Neoadjuvant Radiation for Esophageal Cancer Do Not Affect the Pathologic Complete Response Rate or Survival: A Propensity-Matched Analysis', Annals of Surgical Oncology, vol. 27, no. 2, pp. 500-508.
Eitz, KA, Lo, SS, Soliman, H, Sahgal, A, Theriault, A, Pinkham, MB, Foote, MC, Song, AJ, Shi, W, Redmond, KJ, Gui, C, Kumar, AMS, MacHtay, M, Meyer, B & Combs, SE 2020, 'Multi-institutional Analysis of Prognostic Factors and Outcomes after Hypofractionated Stereotactic Radiotherapy to the Resection Cavity in Patients with Brain Metastases', JAMA Oncology, vol. 6, no. 12, pp. 1901-1909.
Gensheimer, MF, Yom, SS, Soto, N, Dignam, JJ, Le, QT, Machtay, M & Curran, WJ 2020, 'Multicenter Clinical Cancer Research After COVID-19: A Perspective From NRG Oncology', International Journal of Radiation Oncology Biology Physics, vol. 108, no. 2, pp. 483-485.
Yu, Y, Wang, L, Cao, S, Gao, S, Wang, W, Mulvihill, L, Machtay, M, Fu, P, Yu, J & Kong, FM 2020, 'Pre-radiotherapy lymphocyte count and platelet-to-lymphocyte ratio may improve survival prediction beyond clinical factors in limited stage small cell lung cancer: Model development and validation', Translational Lung Cancer Research, vol. 9, no. 6, pp. 2315-2327.
Jin, JY, Gu, A, Wang, W, Oleinick, NL, Machtay, M & (Spring) Kong, FM 2020, 'Ultra-high dose rate effect on circulating immune cells: A potential mechanism for FLASH effect?', Radiotherapy and Oncology, vol. 149, pp. 55-62.
Biswas, T, Kang, KH, Gawdi, R, Bajor, D, Machtay, M, Jindal, C & Efird, JT 2020, 'Using the systemic immune-inflammation index (SII) as a mid-treatment marker for survival among patients with stage-III locally advanced non-small cell lung cancer (NSCLC)', International journal of environmental research and public health, vol. 17, no. 21, 7995, pp. 1-13.


Chen, X, Zheng, Y, Tatsuoka, C, Muzic, RF, Okoye, CC, O'Donnell, JK, Zidar, D, Avril, N, Oliveira, GH, Liu, H, Bucher, J, Machtay, M, Yao, M & Dorth, JA 2019, 'Chemoradiotherapy-related carotid artery inflammation in head and neck cancer patients quantified by [18F]FDG PET/CT', Oral Oncology, vol. 93, pp. 101-106.
Fredman, ET, Traughber, BJ, Gross, A, Podder, T, Colussi, V, Vinkler, R, Machtay, M & Ellis, RJ 2019, 'Comparison of multiparametric MRI-based and transrectal ultrasound-based preplans with intraoperative ultrasound-based planning for low dose rate interstitial prostate seed implantation', Journal of applied clinical medical physics, vol. 20, no. 6, pp. 31-38.
Grubb, WR, Machtay, M, Dowlati, A & Biswas, T 2019, 'Diffuse Atypical Cystic Brain Metastases in ALK+ NSCLC Treated With Whole Brain Radiation and Second-Generation ALK-Targeted Therapy', Practical Radiation Oncology, vol. 9, no. 2, pp. e129-e133.
Hayman, JA, Dekker, A, Feng, M, Keole, SR, McNutt, TR, Machtay, M, Martin, NE, Mayo, CS, Pawlicki, T, Smith, BD, Kudner, R, Dawes, S & Yu, JB 2019, 'Minimum Data Elements for Radiation Oncology: An American Society for Radiation Oncology Consensus Paper', Practical Radiation Oncology, vol. 9, no. 6, pp. 395-401.
Li, Y, Awan, MJ, Chang, T, Lavertu, P, Zender, C, Rezaee, R, Fowler, N, Wasman, J, Avril, NE, Chen, N, Machtay, M & Yao, M 2019, 'Post-radiotherapy PET/CT for predicting treatment outcomes in head and neck cancer after postoperative radiotherapy', European Journal of Nuclear Medicine and Molecular Imaging, vol. 46, no. 4, pp. 794-800.
Bovi, JA, Pugh, SL, Sabsevitz, D, Robinson, CG, Paulson, E, Mehta, MP, Gondi, V, Kundapur, V, Shahin, MS, Chao, ST, Machtay, M, DeNittis, AS, Laack, NN, Greenspoon, JN, Moore, KN, Huang, J, Dominello, MM & Kachnic, LA 2019, 'Pretreatment Volume of MRI-Determined White Matter Injury Predicts Neurocognitive Decline After Hippocampal Avoidant Whole-Brain Radiation Therapy for Brain Metastases: Secondary Analysis of NRG Oncology Radiation Therapy Oncology Group 0933', Advances in Radiation Oncology, vol. 4, no. 4, pp. 579-586.


Fredman, E, Traughber, B, Podder, T, Colussi, V, Zheng, Y, Russo, S, Herrmann, K, Paspulati, R, Waggoner, S, Zanotti, K, Nagel, C, Nakayama, J, Machtay, M & Ellis, RJ 2018, '3T multiparametric MRI–guided high-dose-rate combined intracavitary and interstitial adaptive brachytherapy for the treatment of cervical cancer with a novel split-ring applicator', Brachytherapy, vol. 17, no. 2, pp. 334-344.
Vargo, JA, Ward, MC, Caudell, JJ, Riaz, N, Dunlap, NE, Isrow, D, Zakem, SJ, Dault, J, Awan, MJ, Higgins, KA, Hassanadeh, C, Beitler, JJ, Reddy, CA, Marcrom, S, Boggs, DH, Bonner, JA, Yao, M, Machtay, M, Siddiqui, F, Trotti, AM, Lee, NY, Koyfman, SA, Ferris, RL & Heron, DE 2018, 'A Multi-institutional Comparison of SBRT and IMRT for Definitive Reirradiation of Recurrent or Second Primary Head and Neck Cancer', International Journal of Radiation Oncology Biology Physics, vol. 100, no. 3, pp. 595-605.
Baydoun, A, Vapiwala, N, Ponsky, LE, Awan, M, Kassaee, A, Sutton, D, Podder, TK, Zhang, Y, Dobbins, D, Muzic, RF, Traughber, B, Machtay, M & Ellis, R 2018, 'Comparative analysis for renal stereotactic body radiotherapy using Cyberknife, VMAT and proton therapy based treatment planning', Journal of applied clinical medical physics, vol. 19, no. 3, pp. 125-130.
Frank, SJ, Blanchard, P, Lee, JJ, Sturgis, EM, Kies, MS, Machtay, M, Vikram, B, Garden, AS, Rosenthal, DI, Gunn, GB, Fuller, CD, Hutcheson, K, Lai, S, Busse, PM, Lee, NY, Lin, A & Foote, RL 2018, 'Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation', Seminars in Radiation Oncology, vol. 28, no. 2, pp. 108-113.
Ahn, PH, Machtay, M, Anne, PR, Cognetti, D, Keane, WM, Wuthrick, E, Dicker, AP & Axelrod, RS 2018, 'Phase i Trial Using Induction Ciplatin, Docetaxel, 5-FU and Erlotinib Followed by Cisplatin, Bevacizumab and Erlotinib with Concurrent Radiotherapy for Advanced Head and Neck Cancer', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 41, no. 5, pp. 441-446.
Kumar, AMS, Miller, J, Hoffer, SA, Mansur, DB, Coffey, M, Lo, SS, Sloan, AE & Machtay, M 2018, 'Postoperative hypofractionated stereotactic brain radiation (HSRT) for resected brain metastases: improved local control with higher BED 10', Journal of neuro-oncology, vol. 139, no. 2, pp. 449-454.
Multi-Institution Reirradiation (MIRI) Collaborative 2018, 'Refining Patient Selection for Reirradiation of Head and Neck Squamous Carcinoma in the IMRT Era: A Multi-institution Cohort Study by the MIRI Collaborative', International Journal of Radiation Oncology Biology Physics, vol. 100, no. 3, pp. 586-594.
Yuan, J, Ellis, R & Machtay, M 2018, 'Technical Note: An approach to building a Monte Carlo simulation model for a double scattering proton beam system', Medical Physics, vol. 45, no. 6, pp. 2660-2666.
Multi-Institution Reirradiation (MIRI) Collaborative 2018, 'Volume, Dose, and Fractionation Considerations for IMRT-based Reirradiation in Head and Neck Cancer: A Multi-institution Analysis', International Journal of Radiation Oncology Biology Physics, vol. 100, no. 3, pp. 606-617.


Yuan, J & Machtay, M 2017, 'A Monte Carlo model and its commissioning for the Leksell Gamma Knife Perfexion radiosurgery system', Medical Physics, vol. 44, no. 9, pp. 4910-4918.
Gittleman, H, Lim, D, Kattan, MW, Chakravarti, A, Gilbert, MR, Lassman, AB, Lo, SS, MacHtay, M, Sloan, AE, Sulman, EP, Tian, D, Vogelbaum, MA, Wang, TJC, Penas-Prado, M, Youssef, E, Blumenthal, DT, Zhang, P, Mehta, MP & Barnholtz-Sloan, JS 2017, 'An independently validated nomogram for individualized estimation of survival among patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825', Neuro-oncology, vol. 19, no. 5, pp. 669-677.
Okoye, CC, Bucher, J, Tatsuoka, C, Parikh, SA, Oliveira, GH, Gibson, MK, Machtay, M, Yao, M, Zender, CA & Dorth, JA 2017, 'Cardiovascular risk and prevention in patients with head and neck cancer treated with radiotherapy', Head and Neck, vol. 39, no. 3, pp. 527-532.
Awan, MJ, Dorth, J, Mani, A, Kim, H, Zheng, Y, Mislmani, M, Welford, S, Yuan, J, Wessels, BW, Lo, SS, Letterio, J, Machtay, M, Sloan, A & Sohn, JW 2017, 'Development and Validation of a Small Animal Immobilizer and Positioning System for the Study of Delivery of Intracranial and Extracranial Radiotherapy Using the Gamma Knife System', Technology in Cancer Research and Treatment, vol. 16, no. 2, pp. 203-210.
Bazan, JG, Duan, F, Snyder, BS, Horng, D, Graves, EE, Siegel, BA, Machtay, M & Loo, BW 2017, 'Metabolic tumor volume predicts overall survival and local control in patients with stage III non-small cell lung cancer treated in ACRIN 6668/RTOG 0235', European Journal of Nuclear Medicine and Molecular Imaging, vol. 44, no. 1, pp. 17-24.
Salavati, A, Duan, F, Snyder, BS, Wei, B, Houshmand, S, Khiewvan, B, Opanowski, A, Simone, CB, Siegel, BA, Machtay, M & Alavi, A 2017, 'Optimal FDG PET/CT volumetric parameters for risk stratification in patients with locally advanced non-small cell lung cancer: results from the ACRIN 6668/RTOG 0235 trial', European Journal of Nuclear Medicine and Molecular Imaging, vol. 44, no. 12, pp. 1969-1983.
Baydoun, A, Traughber, B, Morris, N, Abi Zeid Daou, M, McGraw, M, Podder, TK, Muzic, RF, Lo, SS, Ponsky, LE, MacHtay, M & Ellis, R 2017, 'Outcomes and toxicities in patients treated with definitive focal therapy for primary prostate cancer: Systematic review', Future Oncology, vol. 13, no. 7, pp. 649-663.
Awan, MJ, Lavertu, P, Zender, C, Rezaee, R, Fowler, N, Karapetyan, L, Gibson, M, Wasman, J, Faulhaber, P, Machtay, M & Yao, M 2017, 'Post-treatment PET/CT and p16 status for predicting treatment outcomes in locally advanced head and neck cancer after definitive radiation', European Journal of Nuclear Medicine and Molecular Imaging, vol. 44, no. 6, pp. 988-997.
Kong, FMS, Hirsch, FR & Machtay, M 2017, 'Potential future consideration for imaging and blood-based biomarkers for precision medicine in lung cancer', Translational Lung Cancer Research, vol. 6, no. 6, pp. 713-715.
Kang, KH, Efird, JT, Sharma, N, Yang, M, Dowlati, A, Linden, P, MacHtay, M & Biswas, T 2017, 'Prognostic potential of neutrophil-to-lymphocyte ratio and lymphocyte nadir in stage III non-small-cell lung cancer', Future Oncology, vol. 13, no. 16, 0045.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)