Researcher Profile

Researcher Profile

Mitchell Machtay, MD

Mitchell Machtay, MD

Associate Dean for Clinical Cancer Research, Penn State College of Medicine
Professor, Department of Radiation Oncology
Professor, Department of Medicine
Scientific Program:Next-Generation Therapies
Disease Teams:
Brain and Central Nervous System Cancer
Head and Neck Cancer
Thoracic Cancer

Research Interests

  • Radiotherapy
  • Therapeutics
  • Non-Small Cell Lung Carcinoma
  • Neoplasms
  • Survival
  • Head and Neck Neoplasms
  • Radiation
  • Radiation Oncology
  • Radiosurgery
  • Neoplasm Metastasis
  • Drug Therapy
  • Squamous Cell Carcinoma of Head and Neck

Clinical Trials

A Phase 3, Randomized, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Stereotactic Body Radiotherapy (SBRT) with or without Pembrolizumab (MK-3475) in Participants with Medically Inoperable Stages I or IIA Non Small Cell Lung Cancer (NSCLC)(KEYNOTE-867) MK 3475-867
NRG-HN005 - A Randomized Phase II/III Trial of De-intensified Radiation Therapy for Patients with Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer
A Phase II/III Randomized Study of Maintenance Nivolumab versus Observation in Patients with Locally Advanced, Intermediate Risk HPV Positive OPCA
S1827 A randomized Phase III trial comparing prophylactic cranial irradiation (PCI) for any patient with small cell lung cancer (either extensive or limited stage) to active surveillance with MRI in place of PCI
Randomized Phase II/III Trial of Adjuvant Radiation Therapy with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck
KEYSTROKE: A Randomized Phase II Study of Pembrolizumab (KEYTRUDA®) Plus Stereotactic Re-irradiation Versus SBRT Alone for Locoregionally Recurrent or Second Primary Head and Neck Carcinoma
NRG-LU007 Randomized Phase II/III Trial Of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR trial
A Randomized, Phase 2 Study of Stereotactic Body Radiation Therapy (SBRT) in combination with GC4711 in the Treatment of Unresectable or Borderline Resectable, Nonmetastatic Pancreatic Cancer
Randomized Phase III Trial of MEDI4736 (durvalumab) as Concurrent and Consolidative Therapy or Consolidative Therapy Alone for Unresectable Stage 3 NSCLC
NRG HN009- Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin (100 mg/m2) Every Three Weeks Versus Radiation with Low-Dose Weekly Cisplatin (40 mg/m2) for Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)
A Randomized Phase II/III Trial of Modern Immunotherapy Based Systemic Therapy With or Without SBRT for PD-L1-Negative, Advanced Non-Small Cell Lung Cancer

Recent Publications


Deshpande, SR, Grubb, WR, Kharouta, M, Zhang, Y, Zheng, Y, Podder, TK, Towe, C, Young, B, Machtay, M & Biswas, T 2022, 'A Comparative Study of Patients With Early-Stage Non-Small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy Using CyberKnife and Linear Accelerator–Based Volumetric Modulated Arc Therapy', Practical Radiation Oncology, vol. 12, no. 3, pp. 200-209.
Oh, S, Awan, MJ, Monroe, JI, Liang, Y, Wegner, RE, Karlovits, S, Machtay, M, Lo, SS, Sloan, A & Sohn, JW 2022, 'A volume-independent conformity index for stereotactic radiosurgery', Medical Physics, vol. 49, no. 5, pp. 2931-2937.
Biswas, T, Dowlati, A, Kunos, CA, Pink, JJ, Oleinick, NL, Malik, S, Fu, P, Cao, S, Bruno, DS, Bajor, DL, Patel, M, Gerson, SL & Machtay, M 2022, 'Adding Base-Excision Repair Inhibitor TRC102 to Standard Pemetrexed-Platinum-Radiation in Patients with Advanced Nonsquamous Non-Small Cell Lung Cancer: Results of a Phase I Trial', Clinical Cancer Research, vol. 28, no. 4, pp. 646-652.
Damico, NJ, Deshane, A, Kharouta, M, Wu, A, Wang, GM, Machtay, MX, Kumar, A, Choi, S & Bhatt, AD 2022, 'Telemedicine Use and Satisfaction Among Radiation Oncologists During the COVID-19 Pandemic: Evaluation of Current Trends and Future Opportunities', Advances in Radiation Oncology, vol. 7, no. 2, 100835.


Kang, KH, Efird, JT, Podder, TK, Zhang, Y, Dowlati, A, Machtay, M, Jindal, C & Biswas, T 2021, 'A pilot study examining the prognostic utility of tumor shrinkage on cone-beam computed tomography (Cbct) for stage iii locally advanced non-small cell lung cancer patients treated with definitive chemoradiation', International journal of environmental research and public health, vol. 18, no. 6, 3241, pp. 1-8.
Grubb, WR, Ponsky, L, Lo, SS, Kharouta, M, Traughber, B, Sandstrom, K, MacLennan, GT, Shankar, E, Gupta, S, Machtay, M & Ellis, RJ 2021, 'Final results of a dose escalation protocol of stereotactic body radiotherapy for poor surgical candidates with localized renal cell carcinoma', Radiotherapy and Oncology, vol. 155, pp. 138-143.
Fredman, E, Traughber, B, Kharouta, M, Podder, T, Lo, S, Ponsky, L, MacLennan, G, Paspulati, R, Ellis, B, Machtay, M & Ellis, R 2021, 'Focal Prostate Stereotactic Body Radiation Therapy With Correlative Pathological and Radiographic-Based Treatment Planning', Frontiers in Oncology, vol. 11, 744130.
Jin, JY, Hu, C, Xiao, Y, Zhang, H, Paulus, R, Ellsworth, SG, Schild, SE, Bogart, JA, Dobelbower, MC, Kavadi, VS, Narayan, S, Iyengar, P, Robinson, C, Greenberger, JS, Koprowski, C, Machtay, M, Curran, W, Choy, H, Bradley, JD & Kong, FM 2021, 'Higher radiation dose to the immune cells correlates with worse tumor control and overall survival in patients with stage iii nsclc: A secondary analysis of rtog0617', Cancers, vol. 13, no. 24, 6193.
Yu, Y, Fu, P, Jin, JY, Gao, S, Wang, W, Machtay, M, Wang, L, Kong, FM & Yu, J 2021, 'Impact of effective dose to immune cells (EDIC) on lymphocyte nadir and survival in limited-stage SCLC', Radiotherapy and Oncology, vol. 162, pp. 26-33.
Patil, N, Somasundaram, E, Waite, KA, Lathia, JD, Machtay, M, Gilbert, MR, Connor, JR, Rubin, JB, Berens, ME, Buerki, RA, Choi, S, Sloan, AE, Penas-Prado, M, Ashby, LS, Blumenthal, DT, Werner-Wasik, M, Hunter, GK, Flickinger, JC, Wendland, MM, Panet-Raymond, V, Robins, HI, Pugh, SL, Mehta, MP & Barnholtz-Sloan, JS 2021, 'Independently validated sex-specific nomograms for predicting survival in patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825', Journal of neuro-oncology, vol. 155, no. 3, pp. 363-372.
Yuan, J, Fredman, E, Jin, JY, Choi, S, Mansur, D, Sloan, A, Machtay, M & Zheng, Y 2021, 'Monte Carlo Dose Calculation Using MRI Based Synthetic CT Generated by Fully Convolutional Neural Network for Gamma Knife Radiosurgery', Technology in Cancer Research and Treatment, vol. 20.
Biswas, T, Gawdi, R, Jindal, C, Iyer, S, Kang, KH, Bajor, D, Machtay, M, Choi, YM & Efird, JT 2021, 'Pretreatment neutrophil-to-lymphocyte ratio as an important prognostic marker in stage III locally advanced non-small cell lung cancer: Confirmatory results from the PROCLAIM phase III clinical trial', Journal of Thoracic Disease, vol. 13, no. 10, pp. 5617-5626.
Sheikh, S, Kharouta, MZ, Pidikiti, R, Damico, NJ, Choi, S, Dorth, JA, Mansur, DB, Machtay, MX, Yao, M & Bhatt, AD 2022, 'Proton Beam Therapy for Locally Advanced Head and Neck Tumors: An Analysis of Dosimetric and Clinical Outcomes', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 45, no. 2, pp. 81-87.
Damico, NJ, Wu, AK, Kharouta, MZ, Eitan, T, Pidikiti, R, Jesseph, FB, Smith, M, Langmack, C, Mattson, DL, Dobbins, D, Mansur, DB, Machtay, MX, Dorth, JA, Choi, S, Yao, M & Bhatt, AD 2021, 'Proton beam therapy in the treatment of periorbital malignancies', International Journal of Particle Therapy, vol. 7, no. 4, pp. 42-51.
Tchelebi, LT, Batchelder, E, Wang, M, Lehrer, EJ, Drabick, JJ, Sharma, N, MacHtay, M, Trifiletti, DM & Zaorsky, NG 2021, 'Radiotherapy and Receptor Tyrosine Kinase Inhibition for Solid Cancers (ROCKIT): A Meta-Analysis of 13 Studies', JNCI Cancer Spectrum, vol. 5, no. 4, pkab050.
Awan, MJ, Gittleman, H, Barnholtz-Sloan, J, Machtay, M, Nguyen-Tan, PF, Rosenthal, DI, Schultz, C, Huth, BJ, Thorstad, WL, Frank, SJ, Kim, H, Foote, RL, Lango, MN, Shenouda, G, Suntharalingam, M, Harris, J, Zhang, Q, Le, QT & Yao, M 2021, 'Risk groups of laryngeal cancer treated with chemoradiation according to nomogram scores – A pooled analysis of RTOG 0129 and 0522', Oral Oncology, vol. 116, 105241.
Sheikh, S, Dey, A, Datta, S, Podder, TK, Jindal, C, Dowlati, A, Efird, JT, Machtay, M & Biswas, T 2021, 'Role of radiation in extensive stage small cell lung cancer: A National Cancer Database registry analysis', Future Oncology, vol. 17, no. 21, pp. 2713-2724.


Jin, JY, Mereniuk, T, Yalamanchali, A, Wang, W, Machtay, M, (Spring)Kong, FM & Ellsworth, S 2020, 'A framework for modeling radiation induced lymphopenia in radiotherapy', Radiotherapy and Oncology, vol. 144, pp. 105-113.
Wang, W, Huang, L, Jin, JY, Pi, W, Ellsworth, SG, Jolly, S, Mellor, AL, Machtay, M & Kong, FM 2020, 'A validation study on IDO immune biomarkers for survival prediction in non–small cell lung cancer: Radiation dose fractionation effect in early-stage disease', Clinical Cancer Research, vol. 26, no. 1, pp. 282-289.
Rogers, LR, Ostrom, QT, Schroer, J, Vengoechea, J, Li, L, Gerson, S, Nock, CJ, Machtay, M, Selman, W, Lo, S, Sloan, AE & Barnholtz-Sloan, JS 2020, 'Association of metabolic syndrome with glioblastoma: A retrospective cohort study and review', Neuro-Oncology Practice, vol. 7, no. 5, pp. 541-548.
Wang, W, Matuszak, MM, Hu, C, Huang, KC, Chen, E, Arenberg, D, Curtis, JL, Jolly, S, Jin, JY, Machtay, M, Ten Haken, RK & Kong, FM 2020, 'Central Airway Toxicity After High Dose Radiation: A Combined Analysis of Prospective Clinical Trials for Non-Small Cell Lung Cancer', International Journal of Radiation Oncology Biology Physics, vol. 108, no. 3, pp. 587-596.
Sohn, JW, Kim, H, Park, SB, Lee, S, Monroe, JI, Malone, TB, Kinsella, T, Yao, M, Kunos, C, Lo, SS, Shenk, R & Machtay, M 2020, 'Clinical Study of Using Biometrics to Identify Patient and Procedure', Frontiers in Oncology, vol. 10, 586232.
Worrell, SG, Towe, CW, A. Dorth, J, Machtay, M, Perry, Y & Linden, PA 2020, 'Higher Doses of Neoadjuvant Radiation for Esophageal Cancer Do Not Affect the Pathologic Complete Response Rate or Survival: A Propensity-Matched Analysis', Annals of Surgical Oncology, vol. 27, no. 2, pp. 500-508.
Eitz, KA, Lo, SS, Soliman, H, Sahgal, A, Theriault, A, Pinkham, MB, Foote, MC, Song, AJ, Shi, W, Redmond, KJ, Gui, C, Kumar, AMS, MacHtay, M, Meyer, B & Combs, SE 2020, 'Multi-institutional Analysis of Prognostic Factors and Outcomes after Hypofractionated Stereotactic Radiotherapy to the Resection Cavity in Patients with Brain Metastases', JAMA Oncology, vol. 6, no. 12, pp. 1901-1909.
Gensheimer, MF, Yom, SS, Soto, N, Dignam, JJ, Le, QT, Machtay, M & Curran, WJ 2020, 'Multicenter Clinical Cancer Research After COVID-19: A Perspective From NRG Oncology', International Journal of Radiation Oncology Biology Physics, vol. 108, no. 2, pp. 483-485.
Yu, Y, Wang, L, Cao, S, Gao, S, Wang, W, Mulvihill, L, Machtay, M, Fu, P, Yu, J & Kong, FM 2020, 'Pre-radiotherapy lymphocyte count and platelet-to-lymphocyte ratio may improve survival prediction beyond clinical factors in limited stage small cell lung cancer: Model development and validation', Translational Lung Cancer Research, vol. 9, no. 6, pp. 2315-2327.
Jin, JY, Gu, A, Wang, W, Oleinick, NL, Machtay, M & (Spring) Kong, FM 2020, 'Ultra-high dose rate effect on circulating immune cells: A potential mechanism for FLASH effect?', Radiotherapy and Oncology, vol. 149, pp. 55-62.
Biswas, T, Kang, KH, Gawdi, R, Bajor, D, Machtay, M, Jindal, C & Efird, JT 2020, 'Using the systemic immune-inflammation index (SII) as a mid-treatment marker for survival among patients with stage-III locally advanced non-small cell lung cancer (NSCLC)', International journal of environmental research and public health, vol. 17, no. 21, 7995, pp. 1-13.


Chen, X, Zheng, Y, Tatsuoka, C, Muzic, RF, Okoye, CC, O'Donnell, JK, Zidar, D, Avril, N, Oliveira, GH, Liu, H, Bucher, J, Machtay, M, Yao, M & Dorth, JA 2019, 'Chemoradiotherapy-related carotid artery inflammation in head and neck cancer patients quantified by [18F]FDG PET/CT', Oral Oncology, vol. 93, pp. 101-106.
Fredman, ET, Traughber, BJ, Gross, A, Podder, T, Colussi, V, Vinkler, R, Machtay, M & Ellis, RJ 2019, 'Comparison of multiparametric MRI-based and transrectal ultrasound-based preplans with intraoperative ultrasound-based planning for low dose rate interstitial prostate seed implantation', Journal of applied clinical medical physics, vol. 20, no. 6, pp. 31-38.
Grubb, WR, Machtay, M, Dowlati, A & Biswas, T 2019, 'Diffuse Atypical Cystic Brain Metastases in ALK+ NSCLC Treated With Whole Brain Radiation and Second-Generation ALK-Targeted Therapy', Practical Radiation Oncology, vol. 9, no. 2, pp. e129-e133.
Hayman, JA, Dekker, A, Feng, M, Keole, SR, McNutt, TR, Machtay, M, Martin, NE, Mayo, CS, Pawlicki, T, Smith, BD, Kudner, R, Dawes, S & Yu, JB 2019, 'Minimum Data Elements for Radiation Oncology: An American Society for Radiation Oncology Consensus Paper', Practical Radiation Oncology, vol. 9, no. 6, pp. 395-401.
Li, Y, Awan, MJ, Chang, T, Lavertu, P, Zender, C, Rezaee, R, Fowler, N, Wasman, J, Avril, NE, Chen, N, Machtay, M & Yao, M 2019, 'Post-radiotherapy PET/CT for predicting treatment outcomes in head and neck cancer after postoperative radiotherapy', European Journal of Nuclear Medicine and Molecular Imaging, vol. 46, no. 4, pp. 794-800.
Bovi, JA, Pugh, SL, Sabsevitz, D, Robinson, CG, Paulson, E, Mehta, MP, Gondi, V, Kundapur, V, Shahin, MS, Chao, ST, Machtay, M, DeNittis, AS, Laack, NN, Greenspoon, JN, Moore, KN, Huang, J, Dominello, MM & Kachnic, LA 2019, 'Pretreatment Volume of MRI-Determined White Matter Injury Predicts Neurocognitive Decline After Hippocampal Avoidant Whole-Brain Radiation Therapy for Brain Metastases: Secondary Analysis of NRG Oncology Radiation Therapy Oncology Group 0933', Advances in Radiation Oncology, vol. 4, no. 4, pp. 579-586.


Fredman, E, Traughber, B, Podder, T, Colussi, V, Zheng, Y, Russo, S, Herrmann, K, Paspulati, R, Waggoner, S, Zanotti, K, Nagel, C, Nakayama, J, Machtay, M & Ellis, RJ 2018, '3T multiparametric MRI–guided high-dose-rate combined intracavitary and interstitial adaptive brachytherapy for the treatment of cervical cancer with a novel split-ring applicator', Brachytherapy, vol. 17, no. 2, pp. 334-344.
Vargo, JA, Ward, MC, Caudell, JJ, Riaz, N, Dunlap, NE, Isrow, D, Zakem, SJ, Dault, J, Awan, MJ, Higgins, KA, Hassanadeh, C, Beitler, JJ, Reddy, CA, Marcrom, S, Boggs, DH, Bonner, JA, Yao, M, Machtay, M, Siddiqui, F, Trotti, AM, Lee, NY, Koyfman, SA, Ferris, RL & Heron, DE 2018, 'A Multi-institutional Comparison of SBRT and IMRT for Definitive Reirradiation of Recurrent or Second Primary Head and Neck Cancer', International Journal of Radiation Oncology Biology Physics, vol. 100, no. 3, pp. 595-605.
Baydoun, A, Vapiwala, N, Ponsky, LE, Awan, M, Kassaee, A, Sutton, D, Podder, TK, Zhang, Y, Dobbins, D, Muzic, RF, Traughber, B, Machtay, M & Ellis, R 2018, 'Comparative analysis for renal stereotactic body radiotherapy using Cyberknife, VMAT and proton therapy based treatment planning', Journal of applied clinical medical physics, vol. 19, no. 3, pp. 125-130.
Frank, SJ, Blanchard, P, Lee, JJ, Sturgis, EM, Kies, MS, Machtay, M, Vikram, B, Garden, AS, Rosenthal, DI, Gunn, GB, Fuller, CD, Hutcheson, K, Lai, S, Busse, PM, Lee, NY, Lin, A & Foote, RL 2018, 'Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation', Seminars in Radiation Oncology, vol. 28, no. 2, pp. 108-113.
Ahn, PH, Machtay, M, Anne, PR, Cognetti, D, Keane, WM, Wuthrick, E, Dicker, AP & Axelrod, RS 2018, 'Phase i Trial Using Induction Ciplatin, Docetaxel, 5-FU and Erlotinib Followed by Cisplatin, Bevacizumab and Erlotinib with Concurrent Radiotherapy for Advanced Head and Neck Cancer', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 41, no. 5, pp. 441-446.
Kumar, AMS, Miller, J, Hoffer, SA, Mansur, DB, Coffey, M, Lo, SS, Sloan, AE & Machtay, M 2018, 'Postoperative hypofractionated stereotactic brain radiation (HSRT) for resected brain metastases: improved local control with higher BED 10', Journal of neuro-oncology, vol. 139, no. 2, pp. 449-454.
Multi-Institution Reirradiation (MIRI) Collaborative 2018, 'Refining Patient Selection for Reirradiation of Head and Neck Squamous Carcinoma in the IMRT Era: A Multi-institution Cohort Study by the MIRI Collaborative', International Journal of Radiation Oncology Biology Physics, vol. 100, no. 3, pp. 586-594.
Yuan, J, Ellis, R & Machtay, M 2018, 'Technical Note: An approach to building a Monte Carlo simulation model for a double scattering proton beam system', Medical Physics, vol. 45, no. 6, pp. 2660-2666.
Multi-Institution Reirradiation (MIRI) Collaborative 2018, 'Volume, Dose, and Fractionation Considerations for IMRT-based Reirradiation in Head and Neck Cancer: A Multi-institution Analysis', International Journal of Radiation Oncology Biology Physics, vol. 100, no. 3, pp. 606-617.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)