Mitchell Machtay, MD - Penn State Cancer Institute
Researcher Profile
Mitchell Machtay, MD
Associate Dean for Clinical Cancer Research, Penn State College of Medicine
Professor and Endowed Chair in Cancer Clinical Research, Department of Radiation Oncology
Professor, Department of Medicine
Professor and Endowed Chair in Cancer Clinical Research, Department of Radiation Oncology
Professor, Department of Medicine
Scientific Program:Next-Generation Therapies
Disease Teams:
Cancer Institute, Brain and Central Nervous System Cancer Team
Cancer Institute, Head and Neck Cancer Team
Cancer Institute, Thoracic Cancer Team
Cancer Institute, Head and Neck Cancer Team
Cancer Institute, Thoracic Cancer Team
Clinical Trials
NRG-BN013:Phase III Trial of Single Fraction Stereotactic Radiosurgery (SRS) Versus Fractionated SRS (FSRS) for Intact Brain Metastases
A Randomized Phase II/III Trial of Modern Immunotherapy Based Systemic Therapy With or Without Radiation Therapy for PD-L1-Negative, Advanced Non-Small Cell Lung Cancer
Radiopaque Hydrogel Rectal Spacer for Prostate Cancer Radiation Image Guidance
NRG-BN012: A Randomized Phase III Trial of Pre-Operative Compared to Post-Operative Stereotactic Radiosurgery in Patients With Resectable Brain Metastases
ACR 3518: Phase I Safety Assessment of Hypofractionated Postoperative Radiotherapy (H-PORT) for Intermediate-Risk Head and Neck Cancer
The Janus Rectal Cancer Trial: A Randomized Phase II Trial Testing The Efficacy of Triplet Versus Doublet Chemotherapy to Achieve Clinical Complete Response in Patients With Locally Advanced Rectal Cancer
NRG-LU007 Randomized Phase II/III Trial Of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR trial
NRG HN009- Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin (100 mg/m2) Every Three Weeks Versus Radiation with Low-Dose Weekly Cisplatin (40 mg/m2) for Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)
NRG-LU008: Phase III Prospective Randomized Trial Of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed By Concurrent Mediastinal Chemoradiation For Locally Advanced Non-Small Cell Lung Cancer
Recent Publications
2025
Xiao, Y, Benedict, S, Cui, Y, Glide-Hurst, C, Graves, S, Jia, X, Kry, SF, Li, H, Lin, L, Matuszak, M, Newpower, M, Paganetti, H, Qi, XS, Roncali, E, Rong, Y, Sgouros, G, Simone, CB, Sunderland, JJ, Taylor, PA, Tchelebi, L, Weldon, M, Zou, JW, Wuthrick, EJ, Machtay, M, Le, QT & Buchsbaum, JC 2025, 'Embracing the Future of Clinical Trials in Radiation Therapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions', International Journal of Radiation Oncology Biology Physics, vol. 122, no. 2, pp. 443-457. https://doi.org/10.1016/j.ijrobp.2025.01.006
Lorenz, FJ, Kharouta, M, Mahase, SS, Goyal, N, Rezaee, R, Lavertu, P, Machtay, M & Yao, M 2025, 'Hospital-Based Registry Analysis of Staging Efficacy and Proposed Staging Subclassification for Stage I HPV-Associated Oropharyngeal Squamous Cell Carcinoma', Oral Oncology, vol. 163, 107251. https://doi.org/10.1016/j.oraloncology.2025.107251
NRG Oncology RTOG 0920 Collaborating Team 2025, 'Postoperative Radiotherapy ± Cetuximab for Intermediate-Risk Head and Neck Cancer', Journal of Clinical Oncology, vol. 43, no. 12, pp. 1474-1487. https://doi.org/10.1200/JCO-24-01829
Kong, FM, Hu, C, Bradley, JD & Machtay, M 2025, 'Reply to: Mid-Treatment Positron Emission Tomography-Adaptive Radiotherapy in Stage III Non-Small Cell Lung Cancer: Another Attempt Toward Personalized Care', Journal of Clinical Oncology. https://doi.org/10.1200/JCO-25-00069
Mansouri, A, Ozair, A, Bhanja, D, Wilding, H, Mashiach, E, Haque, W, Mikolajewicz, N, de Macedo Filho, L, Mahase, SS, Machtay, M, Metellus, P, Dhermain, F, Sheehan, J, Kondziolka, D, Lunsford, LD, Niranjan, A, Minniti, G, Li, J, Kalkanis, SN, Wen, PY, Kotecha, R, McDermott, MW, Bettegowda, C, Woodworth, GF, Brown, PD, Sahgal, A & Ahluwalia, MS 2025, 'Stereotactic radiosurgery for patients with brain metastases: current principles, expanding indications and opportunities for multidisciplinary care', Nature Reviews Clinical Oncology, vol. 22, no. 5, 101402, pp. 327-347. https://doi.org/10.1038/s41571-025-01013-1
2024
Bruno, DS, Mitchell, C, Dowlati, A, Shamp, S, Fu, P, Rindeau, J, Zheng, Y, Machtay, M & Biswas, T 2024, 'A Pilot Trial of Proton-Based Cardiac Sparing Accelerated Fractionated Radiation Therapy in Unresectable Non-small Cell Lung Cancer With Extended Durvalumab Therapy (PARTICLE-D)', Practical Radiation Oncology, vol. 14, no. 6, pp. e470-e479. https://doi.org/10.1016/j.prro.2024.06.007
Jin, JY, Yuan, J, Qin, X, Li, Y, Yan, H, Oleinick, NL, Yao, M, Pan, Q, Kong, FM & Machtay, M 2024, 'Derivation of a comprehensive semi-empirical proton RBE model from published experimental cell survival data collected in the PIDE database', Frontiers in Oncology, vol. 14, 1415213. https://doi.org/10.3389/fonc.2024.1415213
Chaung, KV, Kharouta, MZ, Gross, AJ, Fu, P, Machtay, M, Hodges, TR, Sloan, AE, Biswas, T, Dowlati, A & Choi, S 2024, 'Outcomes of initial therapy for synchronous brain metastases from small cell lung cancer: a single-institution retrospective analysis', Translational Lung Cancer Research, vol. 13, no. 5, pp. 1110-1120. https://doi.org/10.21037/tlcr-23-641
Kong, FM, Hu, C, Pryma, DA, Duan, F, Matuszak, M, Xiao, Y, Haken, RT, Siegel, MJ, Hanna, L, Curran, W, Dunphy, M, Gelblum, D, Piert, M, Jolly, S, Robinson, CG, Quon, A, Loo, BW, Srinivas, S, Videtic, GM, Faria, SL, Ferguson, C, Dunlap, NE, Kundapur, V, Paulus, R, Siegel, BA, Bradley, JD & Machtay, M 2024, 'Primary Results of NRG-RTOG1106/ECOG-ACRIN 6697: A Randomized Phase II Trial of Individualized Adaptive (chemo)Radiotherapy Using Midtreatment 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Stage III Non–Small Cell Lung Cancer', Journal of Clinical Oncology, vol. 42, no. 33, pp. 3935-3946. https://doi.org/10.1200/JCO.24.00022
Miccio, JA, Potter, NJ, Showkat, A, Yao, M, Mahase, S, Ferenci, M, Sisley, K, Dailey, A, Knipple, J, Blakely, A, Tuanquin, L & Machtay, M 2024, 'Single institution experience of MRI-guided radiotherapy for thoracic tumors and clinical characteristics impacting treatment duty cycle', Frontiers in Oncology, vol. 14, 1401703. https://doi.org/10.3389/fonc.2024.1401703
2023
Rosenberg, J, Le, QT & Machtay, M 2023, History of the Cooperative Group system (National Clinical Trials Network). in Translational Radiation Oncology. Elsevier, pp. 543-549. https://doi.org/10.1016/B978-0-323-88423-5.00037-6
Rogers, CL, Pugh, SL, Vogelbaum, MA, Perry, A, Ashby, LS, Modi, JM, Alleman, AM, Barani, IJ, Braunstein, S, Bovi, JA, de Groot, JF, Whitton, AC, Lindhorst, SM, Deb, N, Shrieve, DC, Shu, HK, Bloom, B, Machtay, M, Mishra, MV, Robinson, CG, Won, M & Mehta, MP 2023, 'Low-risk meningioma: Initial outcomes from NRG Oncology/RTOG 0539', Neuro-oncology, vol. 25, no. 1, pp. 137-145. https://doi.org/10.1093/neuonc/noac137
Gross, AJ, Sheikh, S, Kharouta, M, Chaung, K, Choi, S, Margevicius, S, Fu, P, Machtay, M, Bruno, DS, Dowlati, A & Biswas, T 2023, 'The Impact of Prophylactic Cranial Irradiation and Consolidative Thoracic Radiation Therapy for Extensive Stage Small-Cell Lung Cancer in the Transition to the Chemo-Immunotherapy Era: A Single Institution Series', Clinical Lung Cancer, vol. 24, no. 8, pp. 696-705. https://doi.org/10.1016/j.cllc.2023.08.009
2022
Deshpande, SR, Grubb, WR, Kharouta, M, Zhang, Y, Zheng, Y, Podder, TK, Towe, C, Young, B, Machtay, M & Biswas, T 2022, 'A Comparative Study of Patients With Early-Stage Non-Small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy Using CyberKnife and Linear Accelerator–Based Volumetric Modulated Arc Therapy', Practical Radiation Oncology, vol. 12, no. 3, pp. 200-209. https://doi.org/10.1016/j.prro.2021.12.011
Oh, S, Awan, MJ, Monroe, JI, Liang, Y, Wegner, RE, Karlovits, S, Machtay, M, Lo, SS, Sloan, A & Sohn, JW 2022, 'A volume-independent conformity index for stereotactic radiosurgery', Medical Physics, vol. 49, no. 5, pp. 2931-2937. https://doi.org/10.1002/mp.15619
Biswas, T, Dowlati, A, Kunos, CA, Pink, JJ, Oleinick, NL, Malik, S, Fu, P, Cao, S, Bruno, DS, Bajor, DL, Patel, M, Gerson, SL & Machtay, M 2022, 'Adding Base-Excision Repair Inhibitor TRC102 to Standard Pemetrexed-Platinum-Radiation in Patients with Advanced Nonsquamous Non-Small Cell Lung Cancer: Results of a Phase I Trial', Clinical Cancer Research, vol. 28, no. 4, pp. 646-652. https://doi.org/10.1158/1078-0432.CCR-21-2025
Gillison, ML, Ferris, RL, Harris, J, Colevas, AD, Mell, LK, Kong, C, Jordan, RC, Moore, KL, Truong, MT, Kirsch, C, Chakravarti, A, Blakaj, DM, Clump, DA, Ohr, JP, Deeken, JF, Gensheimer, MF, Saba, NF, Dorth, JA, Rosenthal, DI, Leidner, RS, Kimple, RJ, Machtay, M, Curran, WJ, Torres-Saavedra, P & Le, QT 2023, 'Safety of Nivolumab Added to Chemoradiation Therapy Platforms for Intermediate and High-Risk Locoregionally Advanced Head and Neck Squamous Cell Carcinoma: RTOG Foundation 3504', International Journal of Radiation Oncology Biology Physics, vol. 115, no. 4, pp. 847-860. https://doi.org/10.1016/j.ijrobp.2022.10.008
Damico, NJ, Deshane, A, Kharouta, M, Wu, A, Wang, GM, Machtay, MX, Kumar, A, Choi, S & Bhatt, AD 2022, 'Telemedicine Use and Satisfaction Among Radiation Oncologists During the COVID-19 Pandemic: Evaluation of Current Trends and Future Opportunities', Advances in Radiation Oncology, vol. 7, no. 2, 100835. https://doi.org/10.1016/j.adro.2021.100835
2021
Kang, KH, Efird, JT, Podder, TK, Zhang, Y, Dowlati, A, Machtay, M, Jindal, C & Biswas, T 2021, 'A pilot study examining the prognostic utility of tumor shrinkage on cone-beam computed tomography (Cbct) for stage iii locally advanced non-small cell lung cancer patients treated with definitive chemoradiation', International journal of environmental research and public health, vol. 18, no. 6, 3241, pp. 1-8. https://doi.org/10.3390/ijerph18063241
Grubb, WR, Ponsky, L, Lo, SS, Kharouta, M, Traughber, B, Sandstrom, K, MacLennan, GT, Shankar, E, Gupta, S, Machtay, M & Ellis, RJ 2021, 'Final results of a dose escalation protocol of stereotactic body radiotherapy for poor surgical candidates with localized renal cell carcinoma', Radiotherapy and Oncology, vol. 155, pp. 138-143. https://doi.org/10.1016/j.radonc.2020.10.031
Fredman, E, Traughber, B, Kharouta, M, Podder, T, Lo, S, Ponsky, L, MacLennan, G, Paspulati, R, Ellis, B, Machtay, M & Ellis, R 2021, 'Focal Prostate Stereotactic Body Radiation Therapy With Correlative Pathological and Radiographic-Based Treatment Planning', Frontiers in Oncology, vol. 11, 744130. https://doi.org/10.3389/fonc.2021.744130
Jin, JY, Hu, C, Xiao, Y, Zhang, H, Paulus, R, Ellsworth, SG, Schild, SE, Bogart, JA, Dobelbower, MC, Kavadi, VS, Narayan, S, Iyengar, P, Robinson, C, Greenberger, JS, Koprowski, C, Machtay, M, Curran, W, Choy, H, Bradley, JD & Kong, FM 2021, 'Higher radiation dose to the immune cells correlates with worse tumor control and overall survival in patients with stage iii nsclc: A secondary analysis of rtog0617', Cancers, vol. 13, no. 24, 6193. https://doi.org/10.3390/cancers13246193
Yu, Y, Fu, P, Jin, JY, Gao, S, Wang, W, Machtay, M, Wang, L, Kong, FM & Yu, J 2021, 'Impact of effective dose to immune cells (EDIC) on lymphocyte nadir and survival in limited-stage SCLC', Radiotherapy and Oncology, vol. 162, pp. 26-33. https://doi.org/10.1016/j.radonc.2021.06.020
Patil, N, Somasundaram, E, Waite, KA, Lathia, JD, Machtay, M, Gilbert, MR, Connor, JR, Rubin, JB, Berens, ME, Buerki, RA, Choi, S, Sloan, AE, Penas-Prado, M, Ashby, LS, Blumenthal, DT, Werner-Wasik, M, Hunter, GK, Flickinger, JC, Wendland, MM, Panet-Raymond, V, Robins, HI, Pugh, SL, Mehta, MP & Barnholtz-Sloan, JS 2021, 'Independently validated sex-specific nomograms for predicting survival in patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825', Journal of neuro-oncology, vol. 155, no. 3, pp. 363-372. https://doi.org/10.1007/s11060-021-03886-5
Yuan, J, Fredman, E, Jin, JY, Choi, S, Mansur, D, Sloan, A, Machtay, M & Zheng, Y 2021, 'Monte Carlo Dose Calculation Using MRI Based Synthetic CT Generated by Fully Convolutional Neural Network for Gamma Knife Radiosurgery', Technology in Cancer Research and Treatment, vol. 20. https://doi.org/10.1177/15330338211046433
Biswas, T, Gawdi, R, Jindal, C, Iyer, S, Kang, KH, Bajor, D, Machtay, M, Choi, YM & Efird, JT 2021, 'Pretreatment neutrophil-to-lymphocyte ratio as an important prognostic marker in stage III locally advanced non-small cell lung cancer: Confirmatory results from the PROCLAIM phase III clinical trial', Journal of Thoracic Disease, vol. 13, no. 10, pp. 5617-5626. https://doi.org/10.21037/jtd-21-1018
Sheikh, S, Kharouta, MZ, Pidikiti, R, Damico, NJ, Choi, S, Dorth, JA, Mansur, DB, Machtay, MX, Yao, M & Bhatt, AD 2022, 'Proton Beam Therapy for Locally Advanced Head and Neck Tumors: An Analysis of Dosimetric and Clinical Outcomes', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 45, no. 2, pp. 81-87. https://doi.org/10.1097/COC.0000000000000883
Damico, NJ, Wu, AK, Kharouta, MZ, Eitan, T, Pidikiti, R, Jesseph, FB, Smith, M, Langmack, C, Mattson, DL, Dobbins, D, Mansur, DB, Machtay, MX, Dorth, JA, Choi, S, Yao, M & Bhatt, AD 2021, 'Proton beam therapy in the treatment of periorbital malignancies', International Journal of Particle Therapy, vol. 7, no. 4, pp. 42-51. https://doi.org/10.14338/IJPT-20-00025.1
Tchelebi, LT, Batchelder, E, Wang, M, Lehrer, EJ, Drabick, JJ, Sharma, N, MacHtay, M, Trifiletti, DM & Zaorsky, NG 2021, 'Radiotherapy and Receptor Tyrosine Kinase Inhibition for Solid Cancers (ROCKIT): A Meta-Analysis of 13 Studies', JNCI Cancer Spectrum, vol. 5, no. 4, pkab050. https://doi.org/10.1093/jncics/pkab050
Awan, MJ, Gittleman, H, Barnholtz-Sloan, J, Machtay, M, Nguyen-Tan, PF, Rosenthal, DI, Schultz, C, Huth, BJ, Thorstad, WL, Frank, SJ, Kim, H, Foote, RL, Lango, MN, Shenouda, G, Suntharalingam, M, Harris, J, Zhang, Q, Le, QT & Yao, M 2021, 'Risk groups of laryngeal cancer treated with chemoradiation according to nomogram scores – A pooled analysis of RTOG 0129 and 0522', Oral Oncology, vol. 116, 105241. https://doi.org/10.1016/j.oraloncology.2021.105241
Sheikh, S, Dey, A, Datta, S, Podder, TK, Jindal, C, Dowlati, A, Efird, JT, Machtay, M & Biswas, T 2021, 'Role of radiation in extensive stage small cell lung cancer: A National Cancer Database registry analysis', Future Oncology, vol. 17, no. 21, pp. 2713-2724. https://doi.org/10.2217/fon-2020-1095
Shamp, SJ, Sheikh, S, Chang, T, Damico, N, Linden, P, Dowlati, A, Machtay, M & Biswas, T 2021, 'Stereotactic body radiotherapy (SBRT) for T2N0 (>3 cm) non-small cell lung cancer: Outcomes and failure patterns', Journal of Radiosurgery and SBRT, vol. 7, no. 4, pp. 271-277.