David Goldenberg, MD - Penn State Cancer Institute
Researcher Profile
David Goldenberg, MD
Professor and Chair, Department of Otolaryngology - Head and Neck Surgery
Division of Head and Neck Oncology and Surgery
Professor, Department of Surgery
Professor, Department of Medicine
Division of Head and Neck Oncology and Surgery
Professor, Department of Surgery
Professor, Department of Medicine
Scientific Program:Cancer Control
Disease Teams:
Cancer Institute, Head and Neck Cancer Team
Clinical Trials
Head and Neck Cells: Tissue Repository
Dysgeusia and Anosmia in Head and Neck Cancer Patients: Long Term Outcomes
Recent Publications
2026
Beiriger, J, Estephan, LE, Campbell, D, Dhillon, VK, Goldenberg, D, Noel, J, Orloff, LA, Russell, M, Russell, JO, Sinclair, CF & Cottrill, EE 2026, 'Evaluating Artificial Intelligence Chatbots for Patient Education on Thyroid Radiofrequency Ablation: An Analysis of Accuracy, Quality, and Readability', Thyroid : official journal of the American Thyroid Association, vol. 36, no. 2, pp. 162-168. https://doi.org/10.1177/10507256251414974
Goldenberg, D & Meci, A 2026, 'In Response to Malignant Transformation Rate of Oral Premalignant Disorders: A Large Database Analysis', Laryngoscope, vol. 136, no. 8, pp. E108-E109. https://doi.org/10.1002/lary.70376
Kulkarni, P, Chan, K, Tseng, C, Milarachi, EN, Goldrich, D, LaBarge, B, Walter, V, Goyal, N, Curry, JM, Linnenbach, A, Broach, JR & Goldenberg, D 2026, 'PTPR family deletions are associated with greater genomic structural instability in young adult tongue cancer', Oral Oncology, vol. 176, 107944. https://doi.org/10.1016/j.oraloncology.2026.107944
Sciscent, BY, Eberly, HW, Lorenz, FJ, Goldrich, D, Goyal, N & Goldenberg, D 2026, 'Thyroid Cancer Risk in Patients With Type 2 Diabetes Taking Glucagon-Like Peptide 1 Receptor Agonists', OTO Open, vol. 10, no. 1, e70188. https://doi.org/10.1002/oto2.70188
2025
Meci, A, Goyal, N & Goldenberg, D 2026, 'Branchial Cleft Cyst Carcinoma Remains Grossly Over Diagnosed: A Large Database Analysis', Laryngoscope, vol. 136, no. 2, pp. 766-772. https://doi.org/10.1002/lary.70060
Rossip, M, Lorenz, FJ, Sciscent, B, Truong, N, Nimmagadda, C, Goyal, N & Goldenberg, D 2025, 'Effect of Histamine-2 Receptor Antagonists on Hypocalcemia after Thyroidectomy: A Retrospective Cohort Study and Sensitivity Analysis', Otolaryngology - Head and Neck Surgery (United States), vol. 172, no. 4, pp. 1199-1207. https://doi.org/10.1002/ohn.1140
Meci, A, Lorenz, FJ, Goyal, N & Goldenberg, D 2025, 'Elevated Risk of Thyroid Malignancy in Biological Males Taking Estrogen Hormone Therapy', Otolaryngology - Head and Neck Surgery (United States), vol. 172, no. 4, pp. 1192-1198. https://doi.org/10.1002/ohn.1128
Goldenberg, D 2025, Endocrine Surgery. in Handbook of Otolaryngology: Head and Neck Surgery. Elsevier, pp. 435-479. https://doi.org/10.1016/B978-0-323-88266-8.00008-9
Goldenberg, D & Goldstein, BJ 2025, Foreword. in Handbook of Otolaryngology: Head and Neck Surgery. Elsevier, pp. xv-xv. https://doi.org/10.1016/B978-0-323-88266-8.00018-1
Chan, K, Tseng, C, Milarachi, E, Goldrich, D, Schneper, L, Sheldon, K, Aliaga, C, Alam, S, Chatterjee, S, El-Bayoumy, K, Meyers, C, Goldenberg, D & Broach, JR 2025, 'Genome Instability Precedes Viral Integration in Human Papillomavirus–Transformed Tonsillar Keratinocytes', Molecular Cancer Research, vol. 23, no. 2, pp. 119-127. https://doi.org/10.1158/1541-7786.MCR-24-0604
Goldenberg, D & Goldstein, BJ 2025, Handbook of Otolaryngology: Head and Neck Surgery. Elsevier. https://doi.org/10.1016/C2021-0-01343-2
Rossip, M, Lorenz, FJ, Goyal, N & Goldenberg, D 2025, 'Hypocalcemia After Thyroidectomy in Patients Taking Proton Pump Inhibitors', Laryngoscope investigative otolaryngology, vol. 10, no. 3, e70163. https://doi.org/10.1002/lio2.70163
Heikel, T & Goldenberg, D 2025, 'In-Office Management of Thyroid Nodules', Otolaryngologic Clinics of North America, vol. 58, no. 4, pp. 719-729. https://doi.org/10.1016/j.otc.2025.03.020
Meci, A, Goyal, N & Goldenberg, D 2025, 'Malignant Transformation Rate of Oral Premalignant Disorders: A Large Database Analysis', Laryngoscope, vol. 135, no. 10, pp. 3654-3659. https://doi.org/10.1002/lary.32236
Higgins, RC, Moffatt, DC, Hollenbeak, CS & Goldenberg, D 2025, 'Marital status, race/ethnicity, and outcomes in well-differentiated thyroid cancer in the elderly', Gland Surgery, vol. 14, no. 8, pp. 1599-1611. https://doi.org/10.21037/gs-2025-113
Heikel, T & Goldenberg, D 2025, 'Office-based treatment of thyroid nodules', Operative Techniques in Otolaryngology - Head and Neck Surgery, vol. 36, no. 3, pp. 236-241. https://doi.org/10.1016/j.otot.2025.09.012
Meci, A, Goyal, N & Goldenberg, D 2026, 'The Malignant Transformation Rate of Oral Carcinoma In Situ', Laryngoscope, vol. 136, no. 1, pp. 213-217. https://doi.org/10.1002/lary.70025
2024
Chan, K, Tseng, CC, Milarachi, E, Goldrich, DY, King, TS, Fernandez-Mendoza, J, Saadi, RA, Saunders, B, Boltz, M & Goldenberg, D 2024, 'Actigraphy measures show sleep improvement after parathyroidectomy for primary hyperparathyroidism', American Journal of Otolaryngology - Head and Neck Medicine and Surgery, vol. 45, no. 4, 104297. https://doi.org/10.1016/j.amjoto.2024.104297
Sciscent, BY, Chan, K, Eberly, HW, Goldenberg, D & Goyal, N 2024, 'An Analysis of the Otolaryngology Workforce in Pennsylvania', OTO Open, vol. 8, no. 4, e70026. https://doi.org/10.1002/oto2.70026
Eberly, HW, Sciscent, BY, Lorenz, FJ, Goyal, N & Goldenberg, D 2024, 'Asymptomatic Primary Hyperparathyroidism: A Misnomer', OTO Open, vol. 8, no. 4, e70039. https://doi.org/10.1002/oto2.70039
Eberly, HW, Sciscent, BY, Jeffrey Lorenz, F, Truong, N, King, TS, Goldenberg, D & Goyal, N 2024, 'Evaluation of Hypocalcemia Following Total Laryngectomy With and Without Thyroidectomy', Otolaryngology - Head and Neck Surgery (United States), vol. 171, no. 3, pp. 685-692. https://doi.org/10.1002/ohn.804
Givens, AK, Goyal, N & Goldenberg, D 2024, 'Evolution of the Neck Dissection', Operative Techniques in Otolaryngology - Head and Neck Surgery, vol. 35, no. 4, pp. 290-296. https://doi.org/10.1016/j.otot.2024.08.008
Tucker, J, Ruszkay, N, Sandifer, S, King, T, Goyal, N, Goldenberg, D & Gniady, JP 2024, 'Obesity is a risk factor for prolonged mechanical ventilation after tracheotomy', Laryngoscope investigative otolaryngology, vol. 9, no. 6, e70038. https://doi.org/10.1002/lio2.70038
Goldenberg, D 2024, 'Operative technique in otolaryngology: A milestone issue', Operative Techniques in Otolaryngology - Head and Neck Surgery, vol. 35, no. 3, pp. 205-206. https://doi.org/10.1016/j.otot.2024.08.020
Higgins, RC, King, T, Tucker, J, Engle, L & Goldenberg, D 2024, 'Papillary thyroid microcarcinoma: Does management differ based on facility variables?', American Journal of Otolaryngology - Head and Neck Medicine and Surgery, vol. 45, no. 6, 104460. https://doi.org/10.1016/j.amjoto.2024.104460
Sciscent, BY, Eberly, HW, Lorenz, FJ, Truong, N, Goldenberg, D & Goyal, N 2024, 'Preoperative Serum Albumin as Predictor of Outcomes After Thyroidectomy', OTO Open, vol. 8, no. 1, e114. https://doi.org/10.1002/oto2.114
Eberly, HW, Rosi-Schumacher, M, Sciscent, BY, Truong, N, King, TS, Goldenberg, D & Goyal, N 2026, 'The Use of Fibrin Sealants in Reducing Postoperative Complications in Skull Base Surgery: A Systematic Review and Meta-Analysis', Journal of Neurological Surgery, Part B: Skull Base, vol. 87, no. 1, pp. 63-70. https://doi.org/10.1055/a-2493-1134
Sciscent, BY, Eberly, HW, Goyal, N & Goldenberg, D 2024, 'Thyroid Cancer With Cutaneous Metastases', Ear, Nose and Throat Journal. https://doi.org/10.1177/01455613241239533
2023
Ziai, K, Patel, S, Crenshaw, M, Saadi, R, Goldenberg, D & Lighthall, JG 2025, 'Association of Practice Setting and Scholarly Activity With Medicolegal Claims in Otolaryngology-Head and Neck Surgery', Ear, Nose and Throat Journal, vol. 104, no. 11, pp. 715-722. https://doi.org/10.1177/01455613231158795
Eberly, HW, Sciscent, BY, Jeffrey Lorenz, F, Goyal, N & Goldenberg, D 2024, 'History of Bariatric Surgery Before Thyroid Surgery: Recommendations for Prevention and Management of Postoperative Hypocalcemia', Otolaryngology - Head and Neck Surgery (United States), vol. 170, no. 3, pp. 989-991. https://doi.org/10.1002/ohn.604
Lorenz, FJ & Goldenberg, D 2023, 'Hypocalcemia after parathyroidectomy in patients taking proton pump inhibitors', American Journal of Otolaryngology - Head and Neck Medicine and Surgery, vol. 44, no. 2, 103761. https://doi.org/10.1016/j.amjoto.2022.103761
Bavier, RD & Goldenberg, D 2023, Hypoparathyroidism: LOW PARATHYROID HORMONE LEVELS AFTER THYROID SURGERY: A FEASIBLE PREDICTOR OF HYPOCALCEMIA. in 50 Landmark Papers every Thyroid and Parathyroid Surgeon Should Know. CRC Press, pp. 79-83. https://doi.org/10.1201/9781003196211-15
Moffatt, DC, Tucker, J & Goldenberg, D 2023, 'Management of compression symptoms of thyroid goiters: Hemithyroidectomy is equally as successful as total thyroidectomy', American Journal of Otolaryngology - Head and Neck Medicine and Surgery, vol. 44, no. 1, 103676. https://doi.org/10.1016/j.amjoto.2022.103676
Keane, A, Jardine, K, Goldenberg, D, Pradhan, S, Zhu, J, Mansour, J, Knoller, H, Eshel, R, Talmi, YP, Vaida, S & Slonimsky, G 2023, 'Opioid versus non-opioid postoperative pain management in otolaryngology', BMC Anesthesiology, vol. 23, no. 1, 291. https://doi.org/10.1186/s12871-023-02213-x
Kulkarni, P & Goldenberg, D 2024, 'Surgery for Normocalcemic Hyperparathyroidism', Otolaryngologic Clinics of North America, vol. 57, no. 1, pp. 111-116. https://doi.org/10.1016/j.otc.2023.07.012
Kulkarni, P, Tucker, J, King, T & Goldenberg, D 2023, 'Symptomatic versus asymptomatic primary hyperparathyroidism: A systematic review and meta-analysis', Journal of Clinical and Translational Endocrinology, vol. 32, 100317. https://doi.org/10.1016/j.jcte.2023.100317
Lorenz, FJ, Heikel, T, Tucker, J, Lin, A, Gniady, JP & Goldenberg, D 2024, 'Telemedicine in Otolaryngology in the Context of the End of the COVID-19 Public Health Emergency', Otolaryngology - Head and Neck Surgery (United States), vol. 170, no. 2, pp. 624-626. https://doi.org/10.1002/ohn.550
Goldenberg, D 2023, 'Words Matter: The Dubious Term "Provider"', Southern Medical Journal, vol. 116, no. 7, pp. 535-536. https://doi.org/10.14423/SMJ.0000000000001573
2022
Higgins, RC, Hennessy, M, Aynardi, JT, Goldenberg, D & Goyal, N 2025, 'An invasive tracheal paraganglioma: A rare cause of a thyroid mass', Ear, Nose and Throat Journal, vol. 104, no. 5, pp. 268-271. https://doi.org/10.1177/01455613221112347
Lorenz, FJ, Beauchamp-Perez, F, Manni, A, Chung, T, Goldenberg, D & Goyal, N 2022, 'Analysis of Time to Diagnosis and Outcomes among Adults with Primary Hyperparathyroidism', JAMA network open, vol. 5, no. 12, pp. E2248332. https://doi.org/10.1001/jamanetworkopen.2022.48332
Tucker, J, Milici, J, Alam, S, Ferster, APOC, Goldenberg, D, Meyers, C & Goyal, N 2022, 'Assessing nonsexual transmission of the human papillomavirus (HPV): Do our current cleaning methods work?', Journal of Medical Virology, vol. 94, no. 8, pp. 3956-3961. https://doi.org/10.1002/jmv.27769
Peckham, M, Spencer, HJ, Syed, S, Armstrong, WB, Farwell, DG, Gal, TJ, Goldenberg, D, Russell, MD, Solis, RN, King, D & Stack, BC 2022, 'Breast and thyroid cancer: A multicenter study with Accrual to Clinical Trials Network', Journal of Surgical Oncology, vol. 125, no. 8, pp. 1211-1217. https://doi.org/10.1002/jso.26825
Goyal, N, Goldenberg, D, Ruszkay, N, Tucker, J, May, J & Wilson, MN 2022, 'Can a flexible surgical robot be used in the pediatric population: A feasibility study', International Journal of Pediatric Otorhinolaryngology, vol. 159, 111206. https://doi.org/10.1016/j.ijporl.2022.111206
Labarge, B, Hennessy, M, Zhang, L, Goldrich, D, Chartrand, S, Purnell, C, Wright, S, Goldenberg, D & Broach, JR 2022, 'Human Papillomavirus Integration Strictly Correlates with Global Genome Instability in Head and Neck Cancer', Molecular Cancer Research, vol. 20, no. 9, pp. 1420-1428. https://doi.org/10.1158/1541-7786.MCR-21-0831
Lorenz, FJ, Tucker, J, Milarachi, EN, Hearn, M, King, TS & Goldenberg, D 2022, 'Hypocalcemia after Thyroidectomy in Patients with Prior Bariatric Surgery: A Propensity Score Matched Analysis from a National Administrative Database', Thyroid, vol. 32, no. 11, pp. 1382-1391. https://doi.org/10.1089/thy.2022.0312
Lorenz, FJ & Goldenberg, D 2023, 'Hypocalcemia after parathyroidectomy in patients with a history of bariatric surgery', Endocrine, vol. 79, no. 3, pp. 571-576. https://doi.org/10.1007/s12020-022-03234-1
Keane, A & Goldenberg, D 2022, Nerve Monitoring and Medical Malpractice. in Intraoperative Cranial Nerve Monitoring in Otolaryngology-Head and Neck Surgery. Springer International Publishing, pp. 201-209. https://doi.org/10.1007/978-3-030-84916-0_22
Tucker, J, Ruszkay, N, Goyal, N, Gniady, JP & Goldenberg, D 2022, 'Quality tracheotomy care can be maintained for non-COVID patients during the COVID-19 pandemic', Laryngoscope investigative otolaryngology, vol. 7, no. 5, pp. 1337-1342. https://doi.org/10.1002/lio2.885
Wilson, RT, LaBarge, BL, Stahl, LE, Goldenberg, D, Lyamzina, Y & Talbott, EO 2023, 'What have we learned about health effects more than 40 years after the Three Mile Island nuclear accident? A scoping and process review', Risk, Hazards and Crisis in Public Policy, vol. 14, no. 2, pp. 129-158. https://doi.org/10.1002/rhc3.12258