Ilias Georgakopoulos-Soares, PhD - Penn State Cancer Institute
Researcher Profile
Ilias Georgakopoulos-Soares, PhD
Assistant Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Cancer Control
Research Interests
Dr. Ilias Georgakopoulos-Soares implements bioinformatic and genomics approaches across basic science research problems and in translational medicine.
- DNA
- Neoplasms
- Genome
- Genes
- RNA
- Regulator Genes
- Mutation
- Mutagenesis
- Transcription Factors
- G-Quadruplexes
- Nucleotide Motifs
- Colorectal Neoplasms
Recent Publications
2023
Kanellou, P, Georgakopoulos-Soares, I & Zaravinos, A 2023, 'Deregulated Gene Expression Profiles and Regulatory Networks in Adult and Pediatric RUNX1/RUNX1T1-Positive AML Patients', Cancers, vol. 15, no. 6, 1795. https://doi.org/10.3390/cancers15061795
Georgakopoulos-Soares, I & Zaravinos, A 2023, 'Editorial: Mutational signatures and immune response in cancer', Frontiers in Genetics, vol. 14, 1215326. https://doi.org/10.3389/fgene.2023.1215326
Georgakopoulos-Soares, I, Papazoglou, EL & Markopoulos, AP 2023, 'On the use of the Perlin noise function to calculate the laser absorption coefficient by rough surfaces', Simulation Modelling Practice and Theory, vol. 124, 102722. https://doi.org/10.1016/j.simpat.2022.102722
Mouratidis, I, Chan, CSY, Chantzi, N, Tsiatsianis, GC, Hemberg, M, Ahituv, N & Georgakopoulos-Soares, I 2023, 'Quasi-prime peptides: identification of the shortest peptide sequences unique to a species', NAR Genomics and Bioinformatics, vol. 5, no. 2, lqad039. https://doi.org/10.1093/nargab/lqad039
Liu, Z, Georgakopoulos-Soares, I, Ahituv, N & Wong, KC 2023, 'Risk scoring based on DNA methylation-driven related DEGs for colorectal cancer prognosis with systematic insights', Life Sciences, vol. 316, 121413. https://doi.org/10.1016/j.lfs.2023.121413
Moeckel, C, Zaravinos, A & Georgakopoulos-Soares, I 2023, 'Strand asymmetries across genomic processes', Computational and Structural Biotechnology Journal, vol. 21, pp. 2036-2047. https://doi.org/10.1016/j.csbj.2023.03.007
Moeckel, C, Bakhl, K, Georgakopoulos-Soares, I & Zaravinos, A 2023, 'The Efficacy of Tumor Mutation Burden as a Biomarker of Response to Immune Checkpoint Inhibitors', International journal of molecular sciences, vol. 24, no. 7, 6710. https://doi.org/10.3390/ijms24076710
Georgakopoulos-Soares, I, Deng, C, Agarwal, V, Chan, CSY, Zhao, J, Inoue, F & Ahituv, N 2023, 'Transcription factor binding site orientation and order are major drivers of gene regulatory activity', Nature communications, vol. 14, no. 1, 2333. https://doi.org/10.1038/s41467-023-37960-5
2022
Georgakopoulos-Soares, I, Parada, GE, Wong, HY, Medhi, R, Furlan, G, Munita, R, Miska, EA, Kwok, CK & Hemberg, M 2022, 'Alternative splicing modulation by G-quadruplexes', Nature communications, vol. 13, no. 1, 2404. https://doi.org/10.1038/s41467-022-30071-7
Georgakopoulos-Soares, I, Chan, CSY, Ahituv, N & Hemberg, M 2022, 'Author Correction: High-throughput techniques enable advances in the roles of DNA and RNA secondary structures in transcriptional and post-transcriptional gene regulation (Genome Biology, (2022), 23, 1, (159), 10.1186/s13059-022-02727-6)', Genome biology, vol. 23, no. 1, 164. https://doi.org/10.1186/s13059-022-02733-8
Georgakopoulos-Soares, I, Victorino, J, Parada, GE, Agarwal, V, Zhao, J, Wong, HY, Umar, MI, Elor, O, Muhwezi, A, An, JY, Sanders, SJ, Kwok, CK, Inoue, F, Hemberg, M & Ahituv, N 2022, 'High-throughput characterization of the role of non-B DNA motifs on promoter function', Cell Genomics, vol. 2, no. 4, 100111. https://doi.org/10.1016/j.xgen.2022.100111
Georgakopoulos-Soares, I, Chan, CSY, Ahituv, N & Hemberg, M 2022, 'High-throughput techniques enable advances in the roles of DNA and RNA secondary structures in transcriptional and post-transcriptional gene regulation', Genome biology, vol. 23, no. 1, 159. https://doi.org/10.1186/s13059-022-02727-6
Georgakopoulos-Soares, I, Parada, GE & Hemberg, M 2022, 'Secondary structures in RNA synthesis, splicing and translation', Computational and Structural Biotechnology Journal, vol. 20, pp. 2871-2884. https://doi.org/10.1016/j.csbj.2022.05.041
2021
Georgakopoulos-Soares, I, Yizhar-Barnea, O, Mouratidis, I, Hemberg, M & Ahituv, N 2021, 'Absent from DNA and protein: genomic characterization of nullomers and nullpeptides across functional categories and evolution', Genome biology, vol. 22, no. 1, 245. https://doi.org/10.1186/s13059-021-02459-z
Georgakopoulos-Soares, I, Mouratidis, I, Parada, GE, Matharu, N, Hemberg, M & Ahituv, N 2021, 'Asymmetron: A toolkit for the identification of strand asymmetry patterns in biological sequences', Nucleic acids research, vol. 49, no. 1, pp. E4. https://doi.org/10.1093/nar/gkaa1052
University of Washington Center for Mendelian Genomics 2021, 'Deletion of CTCF sites in the SHH locus alters enhancer–promoter interactions and leads to acheiropodia', Nature communications, vol. 12, no. 1, 2282. https://doi.org/10.1038/s41467-021-22470-z
Roufas, C, Georgakopoulos-Soares, I & Zaravinos, A 2021, 'Distinct genomic features across cytolytic subgroups in skin melanoma', Cancer Immunology, Immunotherapy, vol. 70, no. 11, pp. 3137-3154. https://doi.org/10.1007/s00262-021-02918-3
Parada, GE, Munita, R, Georgakopoulos-Soares, I, Fernandes, HJR, Kedlian, VR, Metzakopian, E, Andres, ME, Miska, EA & Hemberg, M 2021, 'MicroExonator enables systematic discovery and quantification of microexons across mouse embryonic development', Genome biology, vol. 22, no. 1, 43. https://doi.org/10.1186/s13059-020-02246-2
Roufas, C, Georgakopoulos-Soares, I & Zaravinos, A 2021, 'Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis', NAR Cancer, vol. 3, no. 1, zcab005. https://doi.org/10.1093/narcan/zcab005
2020
Degasperi, A, Amarante, TD, Czarnecki, J, Shooter, S, Zou, X, Glodzik, D, Morganella, S, Nanda, AS, Badja, C, Koh, G, Momen, SE, Georgakopoulos-Soares, I, Dias, JML, Young, J, Memari, Y, Davies, H & Nik-Zainal, S 2020, 'A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies', Nature Cancer, vol. 1, no. 2, pp. 249-263. https://doi.org/10.1038/s43018-020-0027-5
Georgakopoulos-Soares, I, Chartoumpekis, DV, Kyriazopoulou, V & Zaravinos, A 2020, 'EMT Factors and Metabolic Pathways in Cancer', Frontiers in Oncology, vol. 10, 499. https://doi.org/10.3389/fonc.2020.00499
Degasperi, A, Amarante, TD, Czarnecki, J, Shooter, S, Zou, X, Glodzik, D, Morganella, S, Nanda, AS, Badja, C, Koh, G, Momen, SE, Georgakopoulos-Soares, I, Dias, JML, Young, J, Memari, Y, Davies, H & Nik-Zainal, S 2020, 'Erratum: Author Correction: A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies (Nature cancer (2020) 1 2 (249-263))', Nature Cancer, vol. 1, no. 7, pp. 748. https://doi.org/10.1038/s43018-020-0093-8
Chartoumpekis, DV, Ziros, PG, Georgakopoulos-Soares, I, Smith, AAT, Marques, AC, Ibberson, M, Kopp, PA, Habeos, I, Trougakos, IP, Khoo, NKH & Sykiotis, GP 2020, 'The transcriptomic response of the murine thyroid gland to iodide overload and the role of the nrf2 antioxidant system', Antioxidants, vol. 9, no. 9, 0884, pp. 1-21. https://doi.org/10.3390/antiox9090884
Georgakopoulos-Soares, I, Koh, G, Momen, SE, Jiricny, J, Hemberg, M & Nik-Zainal, S 2020, 'Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts', Nature communications, vol. 11, no. 1, 1980. https://doi.org/10.1038/s41467-020-15901-w
Gordon, MG, Inoue, F, Martin, B, Schubach, M, Agarwal, V, Whalen, S, Feng, S, Zhao, J, Ashuach, T, Ziffra, R, Kreimer, A, Georgakopoulous-Soares, I, Yosef, N, Ye, CJ, Pollard, KS, Shendure, J, Kircher, M & Ahituv, N 2020, 'lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements', Nature Protocols, vol. 15, no. 8, pp. 2387-2412. https://doi.org/10.1038/s41596-020-0333-5
2019
Petljak, M, Alexandrov, LB, Brammeld, JS, Price, S, Wedge, DC, Grossmann, S, Dawson, KJ, Ju, YS, Iorio, F, Tubio, JMC, Koh, CC, Georgakopoulos-Soares, I, Rodríguez-Martín, B, Otlu, B, O'Meara, S, Butler, AP, Menzies, A, Bhosle, SG, Raine, K, Jones, DR, Teague, JW, Beal, K, Latimer, C, O'Neill, L, Zamora, J, Anderson, E, Patel, N, Maddison, M, Ng, BL, Graham, J, Garnett, MJ, McDermott, U, Nik-Zainal, S, Campbell, PJ & Stratton, MR 2019, 'Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis', Cell, vol. 176, no. 6, pp. 1282-1294.e20. https://doi.org/10.1016/j.cell.2019.02.012