Yong Wang - Penn State Cancer Institute
Researcher Profile
Yong Wang
Professor, Biomedical Engineering
Scientific Program:Next-Generation Therapies
Research Interests
- Hydrogels
- Neoplasms
- Proteins
- Nucleic Acids
- DNA
- Nanoparticles
- Oligonucleotides
- Fibrin
- Vascular Endothelial Growth Factor A
- Pharmaceutical Preparations
- Ligands
- Polymers
Recent Publications
2022
Davis, B, Shi, P, Gaddes, E, Lai, J & Wang, Y 2022, 'Bidirectional Supramolecular Display and Signal Amplification on the Surface of Living Cells', Biomacromolecules, vol. 23, no. 3, pp. 1403-1412. https://doi.org/10.1021/acs.biomac.1c01627
Davila, ML, Xu, M, Huang, C, Gaddes, ER, Winter, L, Cantorna, MT, Wang, Y & Xiong, N 2022, 'CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues', iScience, vol. 25, no. 6, 104426. https://doi.org/10.1016/j.isci.2022.104426
Abune, L, Lee, K & Wang, Y 2022, 'Development of a Biomimetic Extracellular Matrix with Functions of Protein Sequestration and Cell Attachment Using Dual Aptamer-Functionalized Hydrogels', ACS Biomaterials Science and Engineering, vol. 8, no. 3, pp. 1279-1289. https://doi.org/10.1021/acsbiomaterials.1c01544
Shaik, R, Xu, J, Wang, Y, Hong, Y & Zhang, G 2023, 'Fibrin-Enriched Cardiac Extracellular Matrix Hydrogel Promotes In Vitro Angiogenesis', ACS Biomaterials Science and Engineering, vol. 9, no. 2, pp. 877-888. https://doi.org/10.1021/acsbiomaterials.2c01148
Watson, C, Abune, L, Saaid, H, Wen, C, Wang, Y & Manning, KB 2023, 'Performance of a Hydrogel Coated Nitinol with Oligonucleotide-Modified Nanoparticles Within Turbulent Conditions of Blood-Contacting Devices', Cardiovascular Engineering and Technology, vol. 14, no. 2, pp. 239-251. https://doi.org/10.1007/s13239-022-00650-2
Wang, X, Wen, C, Davis, B, Shi, P, Abune, L, Lee, K, Dong, C & Wang, Y 2022, 'Synthetic DNA for Cell Surface Engineering: Experimental Comparison between Click Conjugation and Lipid Insertion in Terms of Cell Viability, Engineering Efficiency, and Displaying Stability', ACS Applied Materials and Interfaces, vol. 14, no. 3, pp. 3900-3909. https://doi.org/10.1021/acsami.1c22774
Xu, R, Abune, L, Davis, B, Ouyang, L, Zhang, G, Wang, Y & Zhe, J 2022, 'Ultrasensitive detection of small biomolecules using aptamer-based molecular recognition and nanoparticle counting', Biosensors and Bioelectronics, vol. 203, 114023. https://doi.org/10.1016/j.bios.2022.114023
2021
Abune, L & Wang, Y 2021, 'Affinity Hydrogels for Protein Delivery', Trends in Pharmacological Sciences, vol. 42, no. 4, pp. 300-312. https://doi.org/10.1016/j.tips.2021.01.005
Abune, L, Davis, B & Wang, Y 2021, 'Aptamer-functionalized hydrogels: An emerging class of biomaterials for protein delivery, cell capture, regenerative medicine, and molecular biosensing', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 13, no. 6, e1731. https://doi.org/10.1002/wnan.1731
Li, C, Xu, M, Coyne, J, Wang, WB, Davila, ML, Wang, Y & Xiong, N 2021, 'Psoriasis-associated impairment of CCL27/CCR10-derived regulation leads to IL-17A/IL-22–producing skin T-cell overactivation', Journal of Allergy and Clinical Immunology, vol. 147, no. 2, pp. 759-763.e9. https://doi.org/10.1016/j.jaci.2020.05.044
Xu, R, Abune, L, Davis, B, Ouyang, L, Zhang, G, Wang, Y & Zhe, J 2021, ULTRA LOW ABUNDANCE BIOMOLECULE DETECTION VIA A MICROPORE. in MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 1623-1624, 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021, Palm Springs, Virtual, United States, 10/10/21.
2020
Yang, J, Kamai, H, Wang, Y & Xu, Y 2020, Aptamer-based nanofluidics for the molecular detection in ultra-small volume. in MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 354-355, 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020, Virtual, Online, 10/4/20.
Coyne, J, Zhao, N, Olubode, A, Menon, M & Wang, Y 2020, 'Development of hydrogel-like biomaterials via nanoparticle assembly and solid-hydrogel transformation', Journal of Controlled Release, vol. 318, pp. 185-196. https://doi.org/10.1016/j.jconrel.2019.12.026
Zhao, N, Coyne, J, Abune, L, Shi, P, Lian, XL, Zhang, G & Wang, Y 2020, 'Exogenous Signaling Molecules Released from Aptamer-Functionalized Hydrogels Promote the Survival of Mesenchymal Stem Cell Spheroids', ACS Applied Materials and Interfaces, vol. 12, no. 22, pp. 24599-24610. https://doi.org/10.1021/acsami.0c05681
Shi, P, Wang, X, Davis, B, Coyne, J, Dong, C, Reynolds, J & Wang, Y 2020, 'In Situ Synthesis of an Aptamer-Based Polyvalent Antibody Mimic on the Cell Surface for Enhanced Interactions between Immune and Cancer Cells', Angewandte Chemie - International Edition, vol. 59, no. 29, pp. 11892-11897. https://doi.org/10.1002/anie.202004206
Wang, Y & Kaplan, D 2020, 'Special Issue: Leaders in Biomedical Engineering', ACS Biomaterials Science and Engineering, vol. 6, no. 5, pp. 2495-2497. https://doi.org/10.1021/acsbiomaterials.0c00606
Shi, P & Wang, Y 2021, 'Synthetic DNA for Cell-Surface Engineering', Angewandte Chemie - International Edition, vol. 60, no. 21, pp. 11580-11591. https://doi.org/10.1002/anie.202010278
2019
Juhl, O, Zhao, N, Merife, AB, Cohen, D, Friedman, M, Zhang, Y, Schwartz, Z, Wang, Y & Donahue, H 2019, 'Aptamer-Functionalized Fibrin Hydrogel Improves Vascular Endothelial Growth Factor Release Kinetics and Enhances Angiogenesis and Osteogenesis in Critically Sized Cranial Defects', ACS Biomaterials Science and Engineering, vol. 5, no. 11, pp. 6152-6160. https://doi.org/10.1021/acsbiomaterials.9b01175
Zhao, N, Coyne, J, Xu, M, Zhang, X, Suzuki, A, Shi, P, Lai, J, Fong, GH, Xiong, N & Wang, Y 2019, 'Assembly of Bifunctional Aptamer-Fibrinogen Macromer for VEGF Delivery and Skin Wound Healing', Chemistry of Materials, vol. 31, no. 3, pp. 1006-1015. https://doi.org/10.1021/acs.chemmater.8b04486
Shi, P, Zhao, N, Coyne, J & Wang, Y 2019, 'DNA-templated synthesis of biomimetic cell wall for nanoencapsulation and protection of mammalian cells', Nature communications, vol. 10, no. 1, 2223. https://doi.org/10.1038/s41467-019-10231-y
Zhao, N, Suzuki, A, Zhang, X, Shi, P, Abune, L, Coyne, J, Jia, H, Xiong, N, Zhang, G & Wang, Y 2019, 'Dual Aptamer-Functionalized in Situ Injectable Fibrin Hydrogel for Promotion of Angiogenesis via Codelivery of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor-BB', ACS Applied Materials and Interfaces, vol. 11, no. 20, pp. 18123-18132. https://doi.org/10.1021/acsami.9b02462
Zhao, N, Suzuki, A, Zhang, X & Wang, Y 2019, Dual aptamer-functionalized in situ injectable fibrin hydrogel for promotion of angiogenesis via co-delivery of growth factors. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Abune, L, Zhao, N, Lai, J, Peterson, B, Szczesny, S & Wang, Y 2019, 'Macroporous hydrogels for stable sequestration and sustained release of vascular endothelial growth factor and basic fibroblast growth factor using nucleic acid aptamers', ACS Biomaterials Science and Engineering. https://doi.org/10.1021/acsbiomaterials.9b00423
Chen, H, Agrawal, S, Dangi, A, Wible, C, Osman, M, Abune, L, Jia, H, Rossi, R, Wang, Y & Kothapalli, SR 2019, 'Optical-resolution photoacoustic microscopy using transparent ultrasound transducer', Sensors (Switzerland), vol. 19, no. 24, 5470. https://doi.org/10.3390/s19245470
Lai, J, Abune, L, Zhao, N & Wang, Y 2019, 'Programmed Degradation of Hydrogels with a Double-Locked Domain', Angewandte Chemie - International Edition, vol. 58, no. 9, pp. 2820-2825. https://doi.org/10.1002/anie.201811848