Yong Wang - Penn State Cancer Institute
Researcher Profile
Yong Wang
Professor, Biomedical Engineering
Scientific Program:Next-Generation Therapies
Research Interests
- Hydrogels
- Neoplasms
- Proteins
- Nucleic Acids
- DNA
- Nanoparticles
- Oligonucleotides
- Fibrin
- Vascular Endothelial Growth Factor A
- Pharmaceutical Preparations
- Ligands
- Polymers
Recent Publications
2024
Wang, X, Jia, B, Lee, K, Davis, B, Wen, C, Wang, Y, Zheng, H & Wang, Y 2024, 'Biomimetic Bacterial Capsule for Enhanced Aptamer Display and Cell Recognition', Journal of the American Chemical Society, vol. 146, no. 1, pp. 868-877. https://doi.org/10.1021/jacs.3c11208
2023
Davis, B, Lee, K, Wang, X & Wang, Y 2023, 'Deoxyribonucleic Acid-Based Polyvalent Ligand-Receptor Binding for Engineering the Cell Surface with Nanoparticles', Biomacromolecules, vol. 24, no. 7, pp. 3193-3202. https://doi.org/10.1021/acs.biomac.3c00264
Wang, X, Wang, Y, Lee, K, Davis, B, Wen, C, Jia, B, Zheng, H, Dong, C & Wang, Y 2023, 'Display of Polyvalent Hybrid Antibodies on the Cell Surface for Enhanced Cell Recognition', Small Methods. https://doi.org/10.1002/smtd.202301331
Abune, L, Wen, C, Lee, K, Wang, X, Ravnic, D & Wang, Y 2024, 'Elastic Macroporous Matrix-Supported In Situ Formation of Injectable Extracellular Matrix-Like Hydrogel for Carrying Growth Factors and Living Cells', Macromolecular Bioscience, vol. 24, no. 3, 2300475. https://doi.org/10.1002/mabi.202300475
Singh, NK, Wang, Y, Wen, C, Davis, B, Wang, X, Lee, K & Wang, Y 2023, 'High-affinity one-step aptamer selection using a non-fouling porous hydrogel', Nature Biotechnology. https://doi.org/10.1038/s41587-023-01973-8
Yang, J, Kamai, H, Wang, Y & Xu, Y 2023, 'Nanofluidic Aptamer Nanoarray to Enable Stochastic Capture of Single Proteins at Normal Concentrations', Small, vol. 19, no. 43, 2301013. https://doi.org/10.1002/smll.202301013
Lee, K, Davis, B, Wang, X, Mirg, S, Wen, C, Abune, L, Peterson, BE, Han, L, Chen, H, Wang, H, Szczesny, SE, Lei, Y, Kothapalli, SR & Wang, Y 2023, 'Nanoparticle-Decorated Biomimetic Extracellular Matrix for Cell Nanoencapsulation and Regulation', Angewandte Chemie - International Edition, vol. 62, no. 31, e202306583. https://doi.org/10.1002/anie.202306583
2022
Davis, B, Shi, P, Gaddes, E, Lai, J & Wang, Y 2022, 'Bidirectional Supramolecular Display and Signal Amplification on the Surface of Living Cells', Biomacromolecules, vol. 23, no. 3, pp. 1403-1412. https://doi.org/10.1021/acs.biomac.1c01627
Davila, ML, Xu, M, Huang, C, Gaddes, ER, Winter, L, Cantorna, MT, Wang, Y & Xiong, N 2022, 'CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues', iScience, vol. 25, no. 6, 104426. https://doi.org/10.1016/j.isci.2022.104426
Abune, L, Lee, K & Wang, Y 2022, 'Development of a Biomimetic Extracellular Matrix with Functions of Protein Sequestration and Cell Attachment Using Dual Aptamer-Functionalized Hydrogels', ACS Biomaterials Science and Engineering, vol. 8, no. 3, pp. 1279-1289. https://doi.org/10.1021/acsbiomaterials.1c01544
Shaik, R, Xu, J, Wang, Y, Hong, Y & Zhang, G 2023, 'Fibrin-Enriched Cardiac Extracellular Matrix Hydrogel Promotes In Vitro Angiogenesis', ACS Biomaterials Science and Engineering, vol. 9, no. 2, pp. 877-888. https://doi.org/10.1021/acsbiomaterials.2c01148
Watson, C, Abune, L, Saaid, H, Wen, C, Wang, Y & Manning, KB 2023, 'Performance of a Hydrogel Coated Nitinol with Oligonucleotide-Modified Nanoparticles Within Turbulent Conditions of Blood-Contacting Devices', Cardiovascular Engineering and Technology, vol. 14, no. 2, pp. 239-251. https://doi.org/10.1007/s13239-022-00650-2
Wang, X, Wen, C, Davis, B, Shi, P, Abune, L, Lee, K, Dong, C & Wang, Y 2022, 'Synthetic DNA for Cell Surface Engineering: Experimental Comparison between Click Conjugation and Lipid Insertion in Terms of Cell Viability, Engineering Efficiency, and Displaying Stability', ACS Applied Materials and Interfaces, vol. 14, no. 3, pp. 3900-3909. https://doi.org/10.1021/acsami.1c22774
Xu, R, Abune, L, Davis, B, Ouyang, L, Zhang, G, Wang, Y & Zhe, J 2022, 'Ultrasensitive detection of small biomolecules using aptamer-based molecular recognition and nanoparticle counting', Biosensors and Bioelectronics, vol. 203, 114023. https://doi.org/10.1016/j.bios.2022.114023
Patel, S, Ershad, F, Zhao, M, Isseroff, RR, Duan, B, Zhou, Y, Wang, Y & Yu, C 2022, 'Wearable electronics for skin wound monitoring and healing', Soft Science, vol. 2, no. 2, 9. https://doi.org/10.20517/ss.2022.13
2021
Abune, L & Wang, Y 2021, 'Affinity Hydrogels for Protein Delivery', Trends in Pharmacological Sciences, vol. 42, no. 4, pp. 300-312. https://doi.org/10.1016/j.tips.2021.01.005
Abune, L, Davis, B & Wang, Y 2021, 'Aptamer-functionalized hydrogels: An emerging class of biomaterials for protein delivery, cell capture, regenerative medicine, and molecular biosensing', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 13, no. 6, e1731. https://doi.org/10.1002/wnan.1731
Li, C, Xu, M, Coyne, J, Wang, WB, Davila, ML, Wang, Y & Xiong, N 2021, 'Psoriasis-associated impairment of CCL27/CCR10-derived regulation leads to IL-17A/IL-22–producing skin T-cell overactivation', Journal of Allergy and Clinical Immunology, vol. 147, no. 2, pp. 759-763.e9. https://doi.org/10.1016/j.jaci.2020.05.044
Xu, R, Abune, L, Davis, B, Ouyang, L, Zhang, G, Wang, Y & Zhe, J 2021, ULTRA LOW ABUNDANCE BIOMOLECULE DETECTION VIA A MICROPORE. in MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 1623-1624, 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021, Palm Springs, Virtual, United States, 10/10/21.
2020
Yang, J, Kamai, H, Wang, Y & Xu, Y 2020, Aptamer-based nanofluidics for the molecular detection in ultra-small volume. in MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 354-355, 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020, Virtual, Online, 10/4/20.
Coyne, J, Zhao, N, Olubode, A, Menon, M & Wang, Y 2020, 'Development of hydrogel-like biomaterials via nanoparticle assembly and solid-hydrogel transformation', Journal of Controlled Release, vol. 318, pp. 185-196. https://doi.org/10.1016/j.jconrel.2019.12.026
Zhao, N, Coyne, J, Abune, L, Shi, P, Lian, XL, Zhang, G & Wang, Y 2020, 'Exogenous Signaling Molecules Released from Aptamer-Functionalized Hydrogels Promote the Survival of Mesenchymal Stem Cell Spheroids', ACS Applied Materials and Interfaces, vol. 12, no. 22, pp. 24599-24610. https://doi.org/10.1021/acsami.0c05681
Shi, P, Wang, X, Davis, B, Coyne, J, Dong, C, Reynolds, J & Wang, Y 2020, 'In Situ Synthesis of an Aptamer-Based Polyvalent Antibody Mimic on the Cell Surface for Enhanced Interactions between Immune and Cancer Cells', Angewandte Chemie - International Edition, vol. 59, no. 29, pp. 11892-11897. https://doi.org/10.1002/anie.202004206
Wang, Y & Kaplan, D 2020, 'Special Issue: Leaders in Biomedical Engineering', ACS Biomaterials Science and Engineering, vol. 6, no. 5, pp. 2495-2497. https://doi.org/10.1021/acsbiomaterials.0c00606
Shi, P & Wang, Y 2021, 'Synthetic DNA for Cell-Surface Engineering', Angewandte Chemie - International Edition, vol. 60, no. 21, pp. 11580-11591. https://doi.org/10.1002/anie.202010278