Seth Bordenstein - Penn State Cancer Institute
Researcher Profile
Seth Bordenstein
Professor, Biology
Professor, Entomology
One Health Microbiome Center
Professor, Entomology
One Health Microbiome Center
Scientific Program:Cancer Control
Recent Publications
2024
Kaur, R, McGarry, A, Dylan Shropshire, J, Leigh, BA & Bordenstein, SR 2024, 'Prophage proteins alter long noncoding RNA and DNA of developing sperm to induce a paternal-effect lethality', Science, vol. 383, no. 6687, pp. 1111-1117. https://doi.org/10.1126/science.adk9469
Kaur, R, Meier, CJ, McGraw, EA, Hillyer, JF & Bordenstein, SR 2024, 'The mechanism of cytoplasmic incompatibility is conserved in Wolbachia-bearing Aedes aegypti mosquitoes deployed for arbovirus control', PLoS biology, vol. 22, no. 3, e3002573. https://doi.org/10.1371/journal.pbio.3002573
2023
Mallott, EK, Sitarik, AR, Leve, LD, Cioffi, C, Camargo, CA, Hasegawa, K & Bordenstein, SR 2023, 'Human microbiome variation associated with race and ethnicity emerges as early as 3 months of age', PLoS biology, vol. 21, no. 8 August, e3002230. https://doi.org/10.1371/journal.pbio.3002230
Ginnan, N & Bordenstein, SR 2023, 'It is time to authenticate the Microbiome Sciences with accredited educational programs and departments', PLoS biology, vol. 21, no. 12, e3002420. https://doi.org/10.1371/journal.pbio.3002420
Chioma, OS, Mallott, E, Shah-Gandhi, B, Wiggins, ZD, Langford, M, Lancaster, AW, Gelbard, A, Wu, H, Johnson, JE, Lancaster, L, Wilfong, EM, Crofford, LJ, Montgomery, CG, Van Kaer, L, Bordenstein, S, Newcomb, DC & Drake, WP 2023, 'Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease', Cells, vol. 12, no. 5, 766. https://doi.org/10.3390/cells12050766
2022
Bell, K & Bordenstein, SR 2022, 'A Margulian View of Symbiosis and Speciation: the Nasonia Wasp System', Symbiosis, vol. 87, no. 1, pp. 3-10. https://doi.org/10.1007/s13199-022-00843-2
Chioma, OS, Mallott, EK, Chapman, A, Van Amburg, JC, Wu, H, Shah-Gandhi, B, Dey, N, Kirkland, ME, Blanca Piazuelo, M, Johnson, J, Bernard, GR, Bodduluri, SR, Davison, S, Haribabu, B, Bordenstein, SR & Drake, WP 2022, 'Gut microbiota modulates lung fibrosis severity following acute lung injury in mice', Communications Biology, vol. 5, no. 1, 1401. https://doi.org/10.1038/s42003-022-04357-x
Li, J, Markowitz, RHG, Brooks, AW, Mallott, EK, Leigh, BA, Olszewski, T, Zare, H, Bagheri, M, Smith, HM, Friese, KA, Habibi, I, Lawrence, WM, Rost, CL, Lédeczi, Á, Eeds, AM, Ferguson, JF, Silver, HJ & Bordenstein, SR 2022, 'Individuality and ethnicity eclipse a short-term dietary intervention in shaping microbiomes and viromes', PLoS biology, vol. 20, no. 8, e3001758. https://doi.org/10.1371/journal.pbio.3001758
Markowitz, RHG, LaBella, AL, Shi, M, Rokas, A, Capra, JA, Ferguson, JF, Mosley, JD & Bordenstein, SR 2022, 'Microbiome-associated human genetic variants impact phenome-wide disease risk', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 26, e2200551119. https://doi.org/10.1073/pnas.2200551119
Kaur, R, Leigh, BA, Ritchie, IT & Bordenstein, SR 2022, 'The Cif proteins from Wolbachia prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility', PLoS biology, vol. 20, no. 5, e3001584. https://doi.org/10.1371/journal.pbio.3001584
Ritchie, IT, Needles, KT, Leigh, BA, Kaur, R & Bordenstein, SR 2022, 'Transgenic cytoplasmic incompatibility persists across age and temperature variation in Drosophila melanogaster', iScience, vol. 25, no. 11, 105327. https://doi.org/10.1016/j.isci.2022.105327
Bordenstein, SR & Bordenstein, SR 2022, 'Widespread phages of endosymbionts: Phage WO genomics and the proposed taxonomic classification of Symbioviridae', PLoS genetics, vol. 18, no. 6, e1010227. https://doi.org/10.1371/journal.pgen.1010227
2021
Perlmutter, JI, Meyers, JE & Bordenstein, SR 2021, 'A single synonymous nucleotide change impacts the male-killing phenotype of prophage wo gene wmk', eLife, vol. 10, e67686. https://doi.org/10.7554/eLife.67686
Cross, KL, Leigh, BA, Hatmaker, EA, Mikaelyan, A, Miller, AK & Bordenstein, SR 2021, 'Genomes of gut bacteria from nasonia wasps shed light on phylosymbiosis and microbe-assisted hybrid breakdown', mSystems, vol. 6, no. 2, e01342-20. https://doi.org/10.1128/MSYSTEMS.01342-20
Kaur, R, Shropshire, JD, Cross, KL, Leigh, B, Mansueto, AJ, Stewart, V, Bordenstein, SR & Bordenstein, SR 2021, 'Living in the endosymbiotic world of Wolbachia: A centennial review', Cell Host and Microbe, vol. 29, no. 6, pp. 879-893. https://doi.org/10.1016/j.chom.2021.03.006
Carrier, TJ, Leigh, BA, Deaker, DJ, Devens, HR, Wray, GA, Bordenstein, SR, Byrne, M & Reitzel, AM 2021, 'Microbiome reduction and endosymbiont gain from a switch in sea urchin life history', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 16, e2022023118. https://doi.org/10.1073/pnas.2022023118
Wang, NC, Bagheri, M, Olszewski, T, Friese, KA, Smith, HM, Robles, ME, Wang, C, Brooks, A, Bordenstein, SR, Ferguson, JF & Silver, HJ 2021, 'New-onset vegetarian diet shows differences in fatty acid metabolites in European American and African American women', Nutrition, Metabolism and Cardiovascular Diseases, vol. 31, no. 8, pp. 2436-2448. https://doi.org/10.1016/j.numecd.2021.05.013
Dutra, HLC, Ford, SA, Allen, SL, Bordenstein, SR, Chenoweth, SF, Bordenstein, SR & McGraw, EA 2021, 'The impact of artificial selection for wolbachia-mediated dengue virus blocking on phage wo', PLoS neglected tropical diseases, vol. 15, no. 7, e0009637. https://doi.org/10.1371/journal.pntd.0009637
Shropshire, JD, Rosenberg, R & Bordenstein, SR 2021, 'The impacts of cytoplasmic incompatibility factor (cifA and cifB) genetic variation on phenotypes', Genetics, vol. 217, no. 1, IYAA007. https://doi.org/10.1093/GENETICS/IYAA007
Miller, AK, Westlake, CS, Cross, KL, Leigh, BA & Bordenstein, SR 2021, 'The microbiome impacts host hybridization and speciation', PLoS biology, vol. 19, no. 10, e3001417. https://doi.org/10.1371/journal.pbio.3001417
2020
Lim, SJ & Bordenstein, SR 2020, 'An introduction to phylosymbiosis', Proceedings of the Royal Society B: Biological Sciences, vol. 287, no. 1922, 20192900. https://doi.org/10.1098/rspb.2019.2900
Lemon, A, Bordenstein, SR & Bordenstein, SR 2020, 'Discover the microbes within! The wolbachia project: Citizen science and student-based discoveries for 15 years and counting', Genetics, vol. 216, no. 2, pp. 263-268. https://doi.org/10.1534/genetics.120.303649
Shropshire, JD, Kalra, M & Bordenstein, SR 2020, 'Evolution-guided mutagenesis of the cytoplasmic incompatibility proteins: Identifying CifA’s complex functional repertoire and new essential regions in CifB', PLoS pathogens, vol. 16, no. 8, e1008794. https://doi.org/10.1371/journal.ppat.1008794
Perlmutter, JI & Bordenstein, SR 2020, 'Microorganisms in the reproductive tissues of arthropods', Nature Reviews Microbiology, vol. 18, no. 2, pp. 97-111. https://doi.org/10.1038/s41579-019-0309-z
Yang, Y, Zheng, W, Cai, Q, Shrubsole, MJ, Pei, Z, Brucker, R, Steinwandel, M, Bordenstein, SR, Li, Z, Blot, WJ, Shu, XO & Long, J 2020, 'Reply to Kenyon, “Are differences in the oral microbiome due to ancestry or socioeconomics?”', mSystems, vol. 5, no. 2, e00891-19. https://doi.org/10.1128/mSystems.00891-19
Shropshire, JD, Leigh, B & Bordenstein, SR 2020, 'Symbiont-mediated cytoplasmic incompatibility: What have we learned in 50 years?', eLife, vol. 9, e61989, pp. 1-36. https://doi.org/10.7554/ELIFE.61989
Martiny, JBH, Whiteson, KL, Bohannan, BJM, David, LA, Hynson, NA, McFall-Ngai, M, Rawls, JF, Schmidt, TM, Abdo, Z, Blaser, MJ, Bordenstein, S, Bréchot, C, Bull, CT, Dorrestein, P, Eisen, JA, Garcia-Pichel, F, Gilbert, J, Hofmockel, KS, Holtz, ML, Knight, R, Mark Welch, DB, McDonald, D, Methé, B, Mouncey, NJ, Mueller, NT, Pfister, CA, Proctor, L & Sachs, JL 2020, 'The emergence of microbiome centres', Nature Microbiology, vol. 5, no. 1, pp. 2-3. https://doi.org/10.1038/s41564-019-0644-x
Perlmutter, JI, Meyers, JE & Bordenstein, SR 2020, 'Transgenic testing does not support a role for additional candidate genes in Wolbachia male killing or cytoplasmic incompatibility', mSystems, vol. 5, no. 1, e00658-19. https://doi.org/10.1128/mSystems.00658-19
McGenity, TJ, Gessesse, A, Hallsworth, JE, Garcia Cela, E, Verheecke-Vaessen, C, Wang, F, Chavarría, M, Haggblom, MM, Molin, S, Danchin, A, Smid, EJ, Lood, C, Cockell, CS, Whitby, C, Liu, SJ, Keller, NP, Stein, LY, Bordenstein, SR, Lal, R, Nunes, OC, Gram, L, Singh, BK, Webster, NS, Morris, C, Sivinski, S, Bindschedler, S, Junier, P, Antunes, A, Baxter, BK, Scavone, P & Timmis, K 2020, 'Visualizing the invisible: class excursions to ignite children’s enthusiasm for microbes', Microbial Biotechnology, vol. 13, no. 4, pp. 844-887. https://doi.org/10.1111/1751-7915.13576