Seth Bordenstein - Penn State Cancer Institute
Researcher Profile
Seth Bordenstein
Professor, Biology
Professor, Entomology
One Health Microbiome Center
Professor, Entomology
One Health Microbiome Center
Scientific Program:Cancer Control
Recent Publications
2025
Kaur, R & Bordenstein, SR 2025, 'Cytoplasmic incompatibility factor proteins from Wolbachia prophage are costly to sperm development in Drosophila melanogaster', Proceedings of the Royal Society B: Biological Sciences, vol. 292, no. 2040, 20243016. https://doi.org/10.1098/rspb.2024.3016
Ginnan, N, Crandall, SG, Imchen, M, Dini-Andreote, F, Miyashiro, TI, Singh, V, Ganda, E & Bordenstein, SR 2025, 'Ecologically expanding the One Health framework to unify the microbiome sciences', mBio, vol. 16, no. 6. https://doi.org/10.1128/mbio.03147-24
Lefoulon, E, Bordenstein, SR, Carpenter, LR, Buchser, JL, Nowicki, CJ, Yakhnina, AA, Gutierrez, JB, Kaur, R, Imchen, M & Bordenstein, SR 2025, 'Evolutionary Diversification and Functions of the Candidate Male Killing Gene wmk', Genome biology and evolution, vol. 17, no. 10, evaf179. https://doi.org/10.1093/gbe/evaf179
Van Syoc, EP, Gomez, A, Davenport, ER & Bordenstein, SR 2025, 'Gut fungal profiles reveal phylosymbiosis and codiversification across humans and nonhuman primates', PLoS biology. https://doi.org/10.1371/journal.pbio.3003390
Van Syoc, EP, Davenport, ER & Bordenstein, SR 2025, 'Gut fungi are associated with human genetic variation and disease risk', PLoS biology, vol. 23, no. 9 September, e3003339. https://doi.org/10.1371/journal.pbio.3003339
Kaur, R, Kalra, M, Imchen, M, Crowley, BL, McGarry, A, Carpenter, L & Bordenstein, SR 2025, 'Histone acetylation modulation by a small molecule inhibitor recapitulates symbiont-induced cytoplasmic incompatibility', Cell Reports, vol. 44, no. 10, 116416. https://doi.org/10.1016/j.celrep.2025.116416
Gilbert, JA, Peixoto, RS, Scholz, AH, Dominguez Bello, MG, Korsten, L, Berg, G, Singh, B, Boetius, A, Wang, F, Greening, C, Wrighton, K, Bordenstein, S, Jansson, JK, Lennon, JT, Souza, V, Thomas, T, Cowan, D, Crowther, TW, Nguyen, N, Harper, L, Haraoui, LP, Ishaq, SL & Redford, K 2025, 'Launching the IUCN Microbial Conservation Specialist Group as a global safeguard for microbial biodiversity', Nature Microbiology, vol. 10, no. 10, pp. 2359-2360. https://doi.org/10.1038/s41564-025-02113-5
Gilbert, JA, Scholz, AH, Dominguez Bello, MG, Korsten, L, Berg, G, Singh, BK, Boetius, A, Wang, F, Greening, C, Wrighton, K, Bordenstein, SR, Jansson, J, Lennon, JT, Souza, V, Allard, SM, Thomas, T, Cowan, D, Crowther, TW, Nguyen, N, Harper, L, Haraoui, LP, Ishaq, SL, McFall-Ngai, M, Redford, KH & Peixoto, R 2025, 'Safeguarding microbial biodiversity: microbial conservation specialist group within the species survival commission of the International Union for Conservation of Nature', ISME Journal, vol. 19, no. 1, wraf239. https://doi.org/10.1093/ismejo/wraf239
Ferretti, P, Martignoni, MM, McManus, LC, Sakal, T, Liaghat, A, Stevens, B, Dahlin, KJM, Souza, LS, Cardon, ZG, Silveira, CB, Bordenstein, SR & Roughgarden, J 2025, 'Theory of host-microbe symbioses: Challenges and opportunities', Cell Host and Microbe, vol. 33, no. 7, pp. 1052-1056. https://doi.org/10.1016/j.chom.2025.05.001
Brunner, A, Gauliard, C, Tutagata, J, Bordenstein, SR, Bordenstein, SR, Trouche, B & Reveillaud, J 2025, 'Wolbachia and its pWCP plasmid show differential dynamics during the development of Culex mosquitoes', Microbiology Spectrum, vol. 13, no. 5. https://doi.org/10.1128/spectrum.00046-25
2024
Kaur, R, McGarry, A, Dylan Shropshire, J, Leigh, BA & Bordenstein, SR 2024, 'Prophage proteins alter long noncoding RNA and DNA of developing sperm to induce a paternal-effect lethality', Science, vol. 383, no. 6687, pp. 1111-1117. https://doi.org/10.1126/science.adk9469
The Holobiont Biology Network 2024, 'The disciplinary matrix of holobiont biology Uniting life’s seen and unseen realms guides a conceptual advance in research', Science, vol. 386, no. 6723, pp. 731-732. https://doi.org/10.1126/science.ado2152
Kaur, R, Meier, CJ, McGraw, EA, Hillyer, JF & Bordenstein, SR 2024, 'The mechanism of cytoplasmic incompatibility is conserved in Wolbachia-bearing Aedes aegypti mosquitoes deployed for arbovirus control', PLoS biology, vol. 22, no. 3, e3002573. https://doi.org/10.1371/journal.pbio.3002573
2023
Mallott, EK, Sitarik, AR, Leve, LD, Cioffi, C, Camargo, CA, Hasegawa, K & Bordenstein, SR 2023, 'Human microbiome variation associated with race and ethnicity emerges as early as 3 months of age', PLoS biology, vol. 21, no. 8 August, e3002230. https://doi.org/10.1371/journal.pbio.3002230
Ginnan, N & Bordenstein, SR 2023, 'It is time to authenticate the Microbiome Sciences with accredited educational programs and departments', PLoS biology, vol. 21, no. 12, e3002420. https://doi.org/10.1371/journal.pbio.3002420
Chioma, OS, Mallott, E, Shah-Gandhi, B, Wiggins, ZD, Langford, M, Lancaster, AW, Gelbard, A, Wu, H, Johnson, JE, Lancaster, L, Wilfong, EM, Crofford, LJ, Montgomery, CG, Van Kaer, L, Bordenstein, S, Newcomb, DC & Drake, WP 2023, 'Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease', Cells, vol. 12, no. 5, 766. https://doi.org/10.3390/cells12050766
2022
Bell, K & Bordenstein, SR 2022, 'A Margulian View of Symbiosis and Speciation: the Nasonia Wasp System', Symbiosis, vol. 87, no. 1, pp. 3-10. https://doi.org/10.1007/s13199-022-00843-2
Chioma, OS, Mallott, EK, Chapman, A, Van Amburg, JC, Wu, H, Shah-Gandhi, B, Dey, N, Kirkland, ME, Blanca Piazuelo, M, Johnson, J, Bernard, GR, Bodduluri, SR, Davison, S, Haribabu, B, Bordenstein, SR & Drake, WP 2022, 'Gut microbiota modulates lung fibrosis severity following acute lung injury in mice', Communications Biology, vol. 5, no. 1, 1401. https://doi.org/10.1038/s42003-022-04357-x
Li, J, Markowitz, RHG, Brooks, AW, Mallott, EK, Leigh, BA, Olszewski, T, Zare, H, Bagheri, M, Smith, HM, Friese, KA, Habibi, I, Lawrence, WM, Rost, CL, Lédeczi, Á, Eeds, AM, Ferguson, JF, Silver, HJ & Bordenstein, SR 2022, 'Individuality and ethnicity eclipse a short-term dietary intervention in shaping microbiomes and viromes', PLoS biology, vol. 20, no. 8, e3001758. https://doi.org/10.1371/journal.pbio.3001758
Markowitz, RHG, LaBella, AL, Shi, M, Rokas, A, Capra, JA, Ferguson, JF, Mosley, JD & Bordenstein, SR 2022, 'Microbiome-associated human genetic variants impact phenome-wide disease risk', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 26, e2200551119. https://doi.org/10.1073/pnas.2200551119
Kaur, R, Leigh, BA, Ritchie, IT & Bordenstein, SR 2022, 'The Cif proteins from Wolbachia prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility', PLoS biology, vol. 20, no. 5, e3001584. https://doi.org/10.1371/journal.pbio.3001584
Ritchie, IT, Needles, KT, Leigh, BA, Kaur, R & Bordenstein, SR 2022, 'Transgenic cytoplasmic incompatibility persists across age and temperature variation in Drosophila melanogaster', iScience, vol. 25, no. 11, 105327. https://doi.org/10.1016/j.isci.2022.105327
Bordenstein, SR & Bordenstein, SR 2022, 'Widespread phages of endosymbionts: Phage WO genomics and the proposed taxonomic classification of Symbioviridae', PLoS genetics, vol. 18, no. 6, e1010227. https://doi.org/10.1371/journal.pgen.1010227