Jordan Bisanz - Penn State Cancer Institute
Researcher Profile
Jordan Bisanz
Assistant Professor, Biochemistry & Molecular Biology
One Health Microbiome Center
One Health Microbiome Center
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2026
Foley, L, Kohli, S, Tian, S, Eisaman, LC, Ganga, H, Hamner, G, Aronson, MR, Bisanz, JE & Medina, SH 2026, 'Core-shell commensal biocapsules for in situ gut microbiome engineering', Bioactive Materials, vol. 65, pp. 796-808. https://doi.org/10.1016/j.bioactmat.2026.05.014
Boyle, NR, Sekela, JJ, Wang, M, Mannochio-Russo, H, Pyo, JJ, Kim, MS, Tian, S, Koo, I, Friedman, ES, Tanes, C, Anitha, M, Tian, Y, Morgan, EW, Murray, IA, Zackular, JP, Bittinger, K, Lewis, JD, Perdew, GH, Wu, GD, Zemel, BS, Dorrestein, PC, Bisanz, JE, Redinbo, MR & Patterson, AD 2026, 'Glucuronidation metabolomic fingerprinting to map host-microbe metabolism', Nature communications, vol. 17, no. 1, 6646. https://doi.org/10.1038/s41467-026-73398-1
Babdor, J, Patel, RK, Davidson, B, Koser, K, Noecker, C, Rahim, MK, Bisanz, JE, Tenvooren, I, Marquez, D, Calvo, M, Johri, V, McCarthy, EE, Shaheed, A, Ekstrand, C, Weakley, AM, Yu, FB, Krip, K, Shaikh, KA, Amatullah, H, Fiehn, O, Turnbaugh, PJ, Combes, AJ, Fragiadakis, GK & Spitzer, MH 2026, 'Immune-microbiome coordination defines interferon setpoints in healthy humans', Cell, vol. 189, no. 10, pp. 3144-3163.e20. https://doi.org/10.1016/j.cell.2026.02.003
Mulisa, G, Zhao, J, Lelissa, G, Ademola-Popoola, IJ, Diaz Huemme, AM, Weyrich, LS, Mihret, A, Gemechu, T, Bane, A, Pero-Gascon, R, De Boevre, M, De Saeger, S, Abebe, T & Bisanz, JE 2026, 'Multi-cohort comparative analysis of salivary microbiotas reveals rural Ethiopians harbor a distinct composition correlated with lower esophageal cancer prevalence', mSystems, vol. 11, no. 6. https://doi.org/10.1128/msystems.00232-26
Liu, P, Linnane, MS, Jump, K, Tian, S, Chaudhary, S, Mani, R, Bisanz, J & Kalantari, P 2026, 'STING agonist protects against exacerbation of schistosome egg-induced immunopathology', PLoS pathogens, vol. 22, no. 7, pp. e1014394. https://doi.org/10.1371/journal.ppat.1014394
2025
Tian, S, Kim, MS, Zhao, J, Heber, K, Hao, F, Koslicki, D, Tian, S, Singh, V, Patterson, AD & Bisanz, JE 2025, 'A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistance', Cell Host and Microbe, vol. 33, no. 3, pp. 373-387.e9. https://doi.org/10.1016/j.chom.2025.02.007
Koo, H, Heber, K, Tian, S, Connolly, ST, Hao, F, Zhao, J, Swencki-Underwood, B, Patterson, AD, Townsend, GE & Bisanz, JE 2025, 'A synthetic gut microbiota provides an understanding of the maintenance and functional impact of phage', mBio, vol. 16, no. 12, pp. 1-19. https://doi.org/10.1128/mbio.02341-25
Zhao, J, Sun, YW, Chen, KM, Aliaga, C, Bisanz, JE & El-Bayoumy, K 2025, 'Black Raspberry Modulates Cecal and Oral Microbiomes at the Early Stage of a Dibenzo[def,p]chrysene-Induced Murine Oral Cancer Model', Cancer Prevention Research, vol. 18, no. 1, pp. 11-21. https://doi.org/10.1158/1940-6207.CAPR-24-0347
Kim, MS & Bisanz, JE 2025, 'Design and application of synthetic human gut microbial communities', Gut microbes, vol. 17, no. 1, 2575923. https://doi.org/10.1080/19490976.2025.2575923
DiMattia, ZS, Zhao, J, Hao, F, Koshkin, S, Bisanz, JE, Patterson, AD, Fleming, JA, Kris-Etherton, PM & Petersen, KS 2025, 'Effect of Varying Quantities of Lean Beef as Part of a Mediterranean-Style Dietary Pattern on Gut Microbiota and Plasma, Fecal, and Urinary Metabolites: A Randomized Crossover Controlled Feeding Trial', Journal of the American Heart Association, vol. 14, no. 19, e041063. https://doi.org/10.1161/JAHA.125.041063
Li, X, Xu, L, Demaree, B, Noecker, C, Bisanz, JE, Weisgerber, DW, Modavi, C, Turnbaugh, PJ & Abate, AR 2025, 'Microbiome Single Cell Atlases Generated with a Commercial Instrument', Advanced Science, vol. 12, no. 27, 2409338. https://doi.org/10.1002/advs.202409338
Mulisa, G, Pero-Gascon, R, McCormack, V, Bisanz, JE, Talukdar, FR, Abebe, T, De Boevre, M & De Saeger, S 2025, 'Multiple mycotoxin exposure assessment through human biomonitoring in an esophageal cancer case-control study in the Arsi-Bale districts of Oromia region of Ethiopia', International Journal of Hygiene and Environmental Health, vol. 263, 114466. https://doi.org/10.1016/j.ijheh.2024.114466
Riley, TM, Wright, J, Lamendella, R, Bisanz, JE, Chen See, J, Kanani, K, Kris-Etherton, PM & Petersen, KS 2025, 'Nighttime Pistachio Consumption Alters Stool Microbiota Diversity and Taxa Abundance Compared with Education to Consume 1–2 Carbohydrate Exchanges (15–30 grams) over 12 Weeks in Adults with Prediabetes: A Secondary Analysis from a Randomized Crossover Trial', Current Developments in Nutrition, vol. 9, no. 7, 107481. https://doi.org/10.1016/j.cdnut.2025.107481
STREAMS Consortium 2025, 'STREAMS guidelines: standards for technical reporting in environmental and host-associated microbiome studies', Nature Microbiology, vol. 10, no. 12, pp. 3059-3068. https://doi.org/10.1038/s41564-025-02186-2
Heber, K, Tian, S, Betancurt-Anzola, D, Koo, H & Bisanz, JE 2025, 'StrainR2 accurately deconvolutes strain-level abundances in synthetic microbial communities', Bioinformatics, vol. 41, no. 8, btaf440. https://doi.org/10.1093/bioinformatics/btaf440
2024
Rimal, B, Collins, SL, Tanes, CE, Rocha, ER, Granda, MA, Solanki, S, Hoque, NJ, Gentry, EC, Koo, I, Reilly, ER, Hao, F, Paudel, D, Singh, V, Yan, T, Kim, MS, Bittinger, K, Zackular, JP, Krausz, KW, Desai, D, Amin, S, Coleman, JP, Shah, YM, Bisanz, JE, Gonzalez, FJ, Vanden Heuvel, JP, Wu, GD, Zemel, BS, Dorrestein, PC, Weinert, EE & Patterson, AD 2024, 'Bile salt hydrolase catalyses formation of amine-conjugated bile acids', Nature, vol. 626, no. 8000, pp. 859-863. https://doi.org/10.1038/s41586-023-06990-w
Tian, Y, Rimal, B, Bisanz, JE, Gui, W, Wolfe, TM, Koo, I, Murray, IA, Nettleford, SK, Yokoyama, S, Dong, F, Koshkin, S, Prabhu, KS, Turnbaugh, PJ, Walk, ST, Perdew, GH & Patterson, AD 2024, 'Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice', Environmental health perspectives, vol. 132, no. 8, 087005. https://doi.org/10.1289/EHP13356
McCurry, MD, D'Agostino, GD, Walsh, JT, Bisanz, JE, Zalosnik, I, Dong, X, Morris, DJ, Korzenik, JR, Edlow, AG, Balskus, EP, Turnbaugh, PJ, Huh, JR & Devlin, AS 2024, 'Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas', Cell, vol. 187, no. 12, pp. 2952-2968.e13. https://doi.org/10.1016/j.cell.2024.05.005
Anderson, BD, Sepulveda, DE, Nachnani, R, Cortez-Resendiz, A, Coates, MD, Beckett, A, Bisanz, JE, Kellogg, JJ & Raup-Konsavage, WM 2024, 'High Cannabigerol Hemp Extract Moderates Colitis and Modulates the Microbiome in an Inflammatory Bowel Disease Model', Journal of Pharmacology and Experimental Therapeutics, vol. 390, no. 3, pp. 331-341. https://doi.org/10.1124/jpet.124.002204
Kyaw, TS, Zhang, C, Sandy, M, Trepka, K, Zhang, S, Ramirez Hernandez, LA, Ramirez, L, Goh, JJN, Yu, K, Dimassa, V, Bess, EN, Brockert, JG, Dumlao, DS, Bisanz, JE & Turnbaugh, PJ 2024, 'Human gut Actinobacteria boost drug absorption by secreting P-glycoprotein ATPase inhibitors', iScience, vol. 27, no. 6, 110122. https://doi.org/10.1016/j.isci.2024.110122
Sepulveda, DE, Vrana, K, Kellogg, J, Bisanz, J, Desai, D, Graziane, NM & Raup-Konsavage, WM 2024, 'The Potential of Cannabichromene (CBC) as a Therapeutic Agent', Journal of Pharmacology and Experimental Therapeutics, vol. 391, no. 2, pp. 206-213. https://doi.org/10.1124/jpet.124.002166
2023
Anderson, BD & Bisanz, JE 2023, 'Challenges and opportunities of strain diversity in gut microbiome research', Frontiers in Microbiology, vol. 14, 1117122. https://doi.org/10.3389/fmicb.2023.1117122
Kim, MS & Bisanz, JE 2023, 'Meta-organismal metabolism in cardiovascular disease', Cell Host and Microbe, vol. 31, no. 1, pp. 1-2. https://doi.org/10.1016/j.chom.2022.12.007
Upadhyay, V, Suryawanshi, RK, Tasoff, P, McCavitt-Malvido, M, Kumar, RG, Murray, VW, Noecker, C, Bisanz, JE, Hswen, Y, Ha, CWY, Sreekumar, B, Chen, IP, Lynch, SV, Ott, M, Lee, S & Turnbaugh, PJ 2023, 'Mild SARS-CoV-2 infection results in long-lasting microbiota instability', mBio, vol. 14, no. 4, pp. e0088923. https://doi.org/10.1128/mbio.00889-23
Carmody, RN & Bisanz, JE 2023, 'Roles of the gut microbiome in weight management', Nature Reviews Microbiology, vol. 21, no. 8, pp. 535-550. https://doi.org/10.1038/s41579-023-00888-0
Noecker, C, Sanchez, J, Bisanz, JE, Escalante, V, Alexander, M, Trepka, K, Heinken, A, Liu, Y, Dodd, D, Thiele, I, DeFelice, BC & Turnbaugh, PJ 2023, 'Systems biology elucidates the distinctive metabolic niche filled by the human gut microbe Eggerthella lenta', PLoS biology, vol. 21, no. 5, e3002125. https://doi.org/10.1371/journal.pbio.3002125
2022
Collins, SL, Stine, JG, Bisanz, JE, Okafor, CD & Patterson, AD 2023, 'Bile acids and the gut microbiota: metabolic interactions and impacts on disease', Nature Reviews Microbiology, vol. 21, no. 4, pp. 236-247. https://doi.org/10.1038/s41579-022-00805-x
Sbierski-Kind, J, Grenkowitz, S, Schlickeiser, S, Sandforth, A, Friedrich, M, Kunkel, D, Glauben, R, Brachs, S, Mai, K, Thürmer, A, Radonić, A, Drechsel, O, Turnbaugh, PJ, Bisanz, JE, Volk, HD, Spranger, J & von Schwartzenberg, RJ 2022, 'Effects of caloric restriction on the gut microbiome are linked with immune senescence', Microbiome, vol. 10, no. 1, 57. https://doi.org/10.1186/s40168-022-01249-4
Paik, D, Yao, L, Zhang, Y, Bae, S, D’Agostino, GD, Zhang, M, Kim, E, Franzosa, EA, Avila-Pacheco, J, Bisanz, JE, Rakowski, CK, Vlamakis, H, Xavier, RJ, Turnbaugh, PJ, Longman, RS, Krout, MR, Clish, CB, Rastinejad, F, Huttenhower, C, Huh, JR & Devlin, AS 2022, 'Human gut bacteria produce ΤΗ17-modulating bile acid metabolites', Nature, vol. 603, no. 7903, pp. 907-912. https://doi.org/10.1038/s41586-022-04480-z
Tian, S & Bisanz, JE 2022, 'Making gut microbiomes from scratch', Cell Host and Microbe, vol. 30, no. 11, pp. 1508-1509. https://doi.org/10.1016/j.chom.2022.10.005