Jordan Bisanz - Penn State Cancer Institute
Researcher Profile
Jordan Bisanz
Assistant Professor, Biochemistry & Molecular Biology
One Health Microbiome Center
One Health Microbiome Center
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2025
Tian, S, Kim, MS, Zhao, J, Heber, K, Hao, F, Koslicki, D, Tian, S, Singh, V, Patterson, AD & Bisanz, JE 2025, 'A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistance', Cell Host and Microbe, vol. 33, no. 3, pp. 373-387.e9. https://doi.org/10.1016/j.chom.2025.02.007
Zhao, J, Sun, YW, Chen, KM, Aliaga, C, Bisanz, JE & El-Bayoumy, K 2025, 'Black Raspberry Modulates Cecal and Oral Microbiomes at the Early Stage of a Dibenzo[def,p]chrysene-Induced Murine Oral Cancer Model', Cancer Prevention Research, vol. 18, no. 1, pp. 11-21. https://doi.org/10.1158/1940-6207.CAPR-24-0347
Mulisa, G, Pero-Gascon, R, McCormack, V, Bisanz, JE, Talukdar, FR, Abebe, T, De Boevre, M & De Saeger, S 2025, 'Multiple mycotoxin exposure assessment through human biomonitoring in an esophageal cancer case-control study in the Arsi-Bale districts of Oromia region of Ethiopia', International Journal of Hygiene and Environmental Health, vol. 263, 114466. https://doi.org/10.1016/j.ijheh.2024.114466
2024
Rimal, B, Collins, SL, Tanes, CE, Rocha, ER, Granda, MA, Solanki, S, Hoque, NJ, Gentry, EC, Koo, I, Reilly, ER, Hao, F, Paudel, D, Singh, V, Yan, T, Kim, MS, Bittinger, K, Zackular, JP, Krausz, KW, Desai, D, Amin, S, Coleman, JP, Shah, YM, Bisanz, JE, Gonzalez, FJ, Vanden Heuvel, JP, Wu, GD, Zemel, BS, Dorrestein, PC, Weinert, EE & Patterson, AD 2024, 'Bile salt hydrolase catalyses formation of amine-conjugated bile acids', Nature, vol. 626, no. 8000, pp. 859-863. https://doi.org/10.1038/s41586-023-06990-w
Tian, Y, Rimal, B, Bisanz, JE, Gui, W, Wolfe, TM, Koo, I, Murray, IA, Nettleford, SK, Yokoyama, S, Dong, F, Koshkin, S, Prabhu, KS, Turnbaugh, PJ, Walk, ST, Perdew, GH & Patterson, AD 2024, 'Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice', Environmental health perspectives, vol. 132, no. 8, 087005. https://doi.org/10.1289/EHP13356
McCurry, MD, D'Agostino, GD, Walsh, JT, Bisanz, JE, Zalosnik, I, Dong, X, Morris, DJ, Korzenik, JR, Edlow, AG, Balskus, EP, Turnbaugh, PJ, Huh, JR & Devlin, AS 2024, 'Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas', Cell, vol. 187, no. 12, pp. 2952-2968.e13. https://doi.org/10.1016/j.cell.2024.05.005
Anderson, BD, Sepulveda, DE, Nachnani, R, Cortez-Resendiz, A, Coates, MD, Beckett, A, Bisanz, JE, Kellogg, JJ & Raup-Konsavage, WM 2024, 'High Cannabigerol Hemp Extract Moderates Colitis and Modulates the Microbiome in an Inflammatory Bowel Disease Model', Journal of Pharmacology and Experimental Therapeutics, vol. 390, no. 3, pp. 331-341. https://doi.org/10.1124/jpet.124.002204
Kyaw, TS, Zhang, C, Sandy, M, Trepka, K, Zhang, S, Ramirez Hernandez, LA, Ramirez, L, Goh, JJN, Yu, K, Dimassa, V, Bess, EN, Brockert, JG, Dumlao, DS, Bisanz, JE & Turnbaugh, PJ 2024, 'Human gut Actinobacteria boost drug absorption by secreting P-glycoprotein ATPase inhibitors', iScience, vol. 27, no. 6, 110122. https://doi.org/10.1016/j.isci.2024.110122
Sepulveda, DE, Vrana, K, Kellogg, J, Bisanz, J, Desai, D, Graziane, NM & Raup-Konsavage, WM 2024, 'The Potential of Cannabichromene (CBC) as a Therapeutic Agent', Journal of Pharmacology and Experimental Therapeutics, vol. 391, no. 2, pp. 206-213. https://doi.org/10.1124/jpet.124.002166
2023
Anderson, BD & Bisanz, JE 2023, 'Challenges and opportunities of strain diversity in gut microbiome research', Frontiers in Microbiology, vol. 14, 1117122. https://doi.org/10.3389/fmicb.2023.1117122
Kim, MS & Bisanz, JE 2023, 'Meta-organismal metabolism in cardiovascular disease', Cell Host and Microbe, vol. 31, no. 1, pp. 1-2. https://doi.org/10.1016/j.chom.2022.12.007
Upadhyay, V, Suryawanshi, RK, Tasoff, P, McCavitt-Malvido, M, Kumar, RG, Murray, VW, Noecker, C, Bisanz, JE, Hswen, Y, Ha, CWY, Sreekumar, B, Chen, IP, Lynch, SV, Ott, M, Lee, S & Turnbaugh, PJ 2023, 'Mild SARS-CoV-2 infection results in long-lasting microbiota instability', mBio, vol. 14, no. 4, pp. e0088923. https://doi.org/10.1128/mbio.00889-23
Carmody, RN & Bisanz, JE 2023, 'Roles of the gut microbiome in weight management', Nature Reviews Microbiology, vol. 21, no. 8, pp. 535-550. https://doi.org/10.1038/s41579-023-00888-0
Noecker, C, Sanchez, J, Bisanz, JE, Escalante, V, Alexander, M, Trepka, K, Heinken, A, Liu, Y, Dodd, D, Thiele, I, DeFelice, BC & Turnbaugh, PJ 2023, 'Systems biology elucidates the distinctive metabolic niche filled by the human gut microbe Eggerthella lenta', PLoS biology, vol. 21, no. 5, e3002125. https://doi.org/10.1371/journal.pbio.3002125
2022
Collins, SL, Stine, JG, Bisanz, JE, Okafor, CD & Patterson, AD 2023, 'Bile acids and the gut microbiota: metabolic interactions and impacts on disease', Nature Reviews Microbiology, vol. 21, no. 4, pp. 236-247. https://doi.org/10.1038/s41579-022-00805-x
Sbierski-Kind, J, Grenkowitz, S, Schlickeiser, S, Sandforth, A, Friedrich, M, Kunkel, D, Glauben, R, Brachs, S, Mai, K, Thürmer, A, Radonić, A, Drechsel, O, Turnbaugh, PJ, Bisanz, JE, Volk, HD, Spranger, J & von Schwartzenberg, RJ 2022, 'Effects of caloric restriction on the gut microbiome are linked with immune senescence', Microbiome, vol. 10, no. 1, 57. https://doi.org/10.1186/s40168-022-01249-4
Paik, D, Yao, L, Zhang, Y, Bae, S, D’Agostino, GD, Zhang, M, Kim, E, Franzosa, EA, Avila-Pacheco, J, Bisanz, JE, Rakowski, CK, Vlamakis, H, Xavier, RJ, Turnbaugh, PJ, Longman, RS, Krout, MR, Clish, CB, Rastinejad, F, Huttenhower, C, Huh, JR & Devlin, AS 2022, 'Human gut bacteria produce ΤΗ17-modulating bile acid metabolites', Nature, vol. 603, no. 7903, pp. 907-912. https://doi.org/10.1038/s41586-022-04480-z
Tian, S & Bisanz, JE 2022, 'Making gut microbiomes from scratch', Cell Host and Microbe, vol. 30, no. 11, pp. 1508-1509. https://doi.org/10.1016/j.chom.2022.10.005
2021
von Schwartzenberg, RJ, Bisanz, JE, Lyalina, S, Spanogiannopoulos, P, Ang, QY, Cai, J, Dickmann, S, Friedrich, M, Liu, SY, Collins, SL, Ingebrigtsen, D, Miller, S, Turnbaugh, JA, Patterson, AD, Pollard, KS, Mai, K, Spranger, J & Turnbaugh, PJ 2021, 'Caloric restriction disrupts the microbiota and colonization resistance', Nature, vol. 595, no. 7866, pp. 272-277. https://doi.org/10.1038/s41586-021-03663-4
Lam, KN, Spanogiannopoulos, P, Soto-Perez, P, Alexander, M, Nalley, MJ, Bisanz, JE, Nayak, RR, Weakley, AM, Yu, FB & Turnbaugh, PJ 2021, 'Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome', Cell Reports, vol. 37, no. 5, 109930. https://doi.org/10.1016/j.celrep.2021.109930
Genomic Standards Consortium & Massive Analysis and Quality Control Society 2021, 'Reporting guidelines for human microbiome research: the STORMS checklist', Nature Medicine, vol. 27, no. 11, pp. 1885-1892. https://doi.org/10.1038/s41591-021-01552-x
Ang, QY, Alba, DL, Upadhyay, V, Bisanz, JE, Cai, J, Lee, HL, Barajas, E, Wei, G, Noecker, C, Patterson, AD, Koliwad, SK & Turnbaugh, PJ 2021, 'The east asian gut microbiome is distinct from colocalized white subjects and connected to metabolic health', eLife, vol. 10, e70349. https://doi.org/10.7554/eLife.70349