Sean Mahase, MD - Penn State Cancer Institute
Researcher Profile
Sean Mahase, MD
Assistant Professor, Department of Radiation Oncology
Scientific Program:Experimental Therapeutics
Clinical Trials
NRG-BN013: Phase III Trial of Single Fraction Stereotactic Radiosurgery (SRS) Versus Fractionated SRS (FSRS) for Intact Brain Metastases
NRG-CC013: A Randomized, Masked, Placebo Controlled, Phase II Trial Of Concurrent Chemoradiation With Bmx-001 In Patients With Head And Neck Squamous Cell Carcinoma Receiving Concurrent Chemoradiation
Long-term Follow-up of AAV2-hAQP1 Gene Therapy in Participants with Radiation-Induced Late Xerostomia- MGT-AQP1-202
Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer
Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) with Low-Dose Post-Transplant Cyclophosphamide for Prophylaxis of Graft-versus-Host Disease in Hematological Malignancies
A Multicenter Observational Study of GammaTile Surgically Targeted Radiation Therapy (STaRT) in Intracranial Brain Neoplasms
Maintenance Obinutuzumab for Primary Central Nervous System Lymphoma Complete or Partial Responders
Recent Publications
2026
Kutuk, T, Atak, E, Harrell, M, Raval, RR, Fekrmandi, F, Zhu, S, Beyer, S, Singh, PK, Giglio, P, Mohtashami, H, Wu, KC, Elder, JB, Mahase, SS, Singh, R, Chakravarti, A & Palmer, JD 2026, 'Boron Neutron Capture Therapy for High-Grade CNS Tumors: Mechanisms, Carriers, and Clinical Progress: A Narrative Review', International journal of molecular sciences, vol. 27, no. 6, 2765. https://doi.org/10.3390/ijms27062765
2025
Mansouri, A, Ozair, A, Bhanja, D, Wilding, H, Mashiach, E, Haque, W, Mikolajewicz, N, de Macedo Filho, L, Mahase, SS, Machtay, M, Metellus, P, Dhermain, F, Sheehan, J, Kondziolka, D, Lunsford, LD, Niranjan, A, Minniti, G, Li, J, Kalkanis, SN, Wen, PY, Kotecha, R, McDermott, MW, Bettegowda, C, Woodworth, GF, Brown, PD, Sahgal, A & Ahluwalia, MS 2025, 'Author Correction: Stereotactic radiosurgery for patients with brain metastases: current principles, expanding indications and opportunities for multidisciplinary care (Nature Reviews Clinical Oncology, (2025), 22, 5, (327-347), 10.1038/s41571-025-01013-1)', Nature Reviews Clinical Oncology, vol. 22, no. 12, pp. 996. https://doi.org/10.1038/s41571-025-01083-1
Layng, SC, Betsock, A, Mansouri, A, Komiya, T, Miccio, JA, Mahase, SS & Knisely, JPS 2025, 'Brain metastases from lung cancer: recent advances and novel therapeutic opportunities', Discover Oncology, vol. 16, no. 1, 157. https://doi.org/10.1007/s12672-025-01873-0
Lorenz, FJ, Kharouta, M, Mahase, SS, Goyal, N, Rezaee, R, Lavertu, P, Machtay, M & Yao, M 2025, 'Hospital-Based Registry Analysis of Staging Efficacy and Proposed Staging Subclassification for Stage I HPV-Associated Oropharyngeal Squamous Cell Carcinoma', Oral Oncology, vol. 163, 107251. https://doi.org/10.1016/j.oraloncology.2025.107251
Mansouri, A, Ozair, A, Bhanja, D, Wilding, H, Mashiach, E, Haque, W, Mikolajewicz, N, de Macedo Filho, L, Mahase, SS, Machtay, M, Metellus, P, Dhermain, F, Sheehan, J, Kondziolka, D, Lunsford, LD, Niranjan, A, Minniti, G, Li, J, Kalkanis, SN, Wen, PY, Kotecha, R, McDermott, MW, Bettegowda, C, Woodworth, GF, Brown, PD, Sahgal, A & Ahluwalia, MS 2025, 'Stereotactic radiosurgery for patients with brain metastases: current principles, expanding indications and opportunities for multidisciplinary care', Nature Reviews Clinical Oncology, vol. 22, no. 5, 101402, pp. 327-347. https://doi.org/10.1038/s41571-025-01013-1
2024
Miccio, JA, Tian, Z, Mahase, SS, Lin, C, Choi, S, Zacharia, BE, Sheehan, JP, Brown, PD, Trifiletti, DM, Palmer, JD, Wang, M & Zaorsky, NG 2024, 'Estimating the risk of brain metastasis for patients newly diagnosed with cancer', Communications Medicine, vol. 4, no. 1, 27. https://doi.org/10.1038/s43856-024-00445-7
Kozak, MM, Mahase, S, Traughber, B, Machtay, M & Buatti, J 2024, MR-Guided Radiotherapy in the Pediatric and Adolescent Patient. in A Practical Guide to MR-Linac: Technical Innovation and Clinical Implication. Springer International Publishing, pp. 355-373. https://doi.org/10.1007/978-3-031-48165-9_19
Miccio, JA, Potter, NJ, Showkat, A, Yao, M, Mahase, S, Ferenci, M, Sisley, K, Dailey, A, Knipple, J, Blakely, A, Tuanquin, L & Machtay, M 2024, 'Single institution experience of MRI-guided radiotherapy for thoracic tumors and clinical characteristics impacting treatment duty cycle', Frontiers in Oncology, vol. 14, 1401703. https://doi.org/10.3389/fonc.2024.1401703
Kharouta, M, Lorenz, FJ, Mahase, S, Shi, H, Goyal, N & Yao, M 2024, 'The Role of Radiotherapy to the Primary Site in Oropharyngeal Cancer with Limited Metastases—An Analysis of a Hospital-Based Registry', Cancers, vol. 16, no. 24, 4130. https://doi.org/10.3390/cancers16244130
2023
Mahase, SS 2023, 'Can't Touch This, But Can We Treat That? Ethical Considerations', International Journal of Radiation Oncology Biology Physics, vol. 116, no. 5, pp. 976. https://doi.org/10.1016/j.ijrobp.2023.03.053
Mahase, SS, Roytman, M, Roth O'Brien, D, Ivanidze, J, Schwartz, TH, Pannullo, SC, Ramakrishna, R, Magge, RS, Williams, N, Fine, HA, Chiang, GCY & Knisely, JPS 2023, 'Concurrent immunotherapy and re-irradiation utilizing stereotactic body radiotherapy for recurrent high-grade gliomas', Cancer Reports, vol. 6, no. 7, e1788. https://doi.org/10.1002/cnr2.1788
Rodriguez, J, Martinez, G, Mahase, S, Roytman, M, Haghdel, A, Kim, S, Madera, G, Magge, R, Pan, P, Ramakrishna, R, Schwartz, TH, Pannullo, SC, Osborne, JR, Lin, E, Knisely, JPS, Sanelli, PC & Ivanidze, J 2023, 'Cost-Effectiveness Analysis of 68Ga-DOTATATE PET/MRI in Radiotherapy Planning in Patients with Intermediate-Risk Meningioma', American Journal of Neuroradiology, vol. 44, no. 7, pp. 783-791. https://doi.org/10.3174/ajnr.A7901
Choi, KY, Patel, SD, Lane, C, Tucker, J, Chan, K, Pradhan, S, Mahase, SS, Tam, SH & King, TS 2024, 'Elucidating survival and functional outcomes in patients with primary head and neck malignancies treated in academic versus community settings', Head and Neck, vol. 46, no. 2, pp. 398-407. https://doi.org/10.1002/hed.27588
Lorenz, FJ, Mahase, SS, Miccio, J, King, TS, Pradhan, S & Goyal, N 2023, 'Update on adherence to guidelines for time to initiation of postoperative radiation for head and neck squamous cell carcinoma', Head and Neck, vol. 45, no. 7, pp. 1676-1691. https://doi.org/10.1002/hed.27380
2022
Mahase, S & Nagar, H 2022, 'Corrigendum re “Hypofractionated Postoperative Radiotherapy for Prostate Cancer: Is the Field Ready Yet?” [Eur Urol Open Sci 2020;22:9–16](S2666168320358328)(10.1016/j.euros.2020.10.001)', European Urology Open Science, vol. 44, pp. 52-53. https://doi.org/10.1016/j.euros.2022.08.012
Mahase, SS, Singh, B, Wong, RJ, Ganly, I, Boyle, JO, Patel, SG & Lee, NY 2022, 'Primary chondrosarcomas of the larynx treated with proton radiotherapy: A single institutional experience', Cancer Reports, vol. 5, no. 9, e1621. https://doi.org/10.1002/cnr2.1621