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Researcher Profile

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Joseph Miccio, MD

Joseph Miccio, MD

Assistant Professor and Director of Genitourinary Cancer, Department of Radiation Oncology
Scientific Program:Next-Generation Therapies

Research Interests

  • Radiotherapy
  • Survival
  • Therapeutics
  • Neoplasms
  • Radiosurgery
  • Radiation
  • Pancreatic Neoplasms
  • Databases
  • Drug Therapy
  • Epidemiology
  • Registries
  • Adenocarcinoma

Clinical Trials

CCTG MA.39:Tailor RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive and T3N0 Breast Cancer
NRG-GU011: A Phase II Double-Blinded, Placebo-Controlled Trial of PROstate OligoMETastatic RadiotHErapy With or Without ANdrogen Deprivation Therapy in Oligometastatic Prostate Cancer (NRG Promethean)
A Randomized Phase II/III Trial of Modern Immunotherapy Based Systemic Therapy With or Without SBRT for PD-L1-Negative, Advanced Non-Small Cell Lung Cancer
Radiopaque Hydrogel Rectal Spacer for Prostate Cancer Radiation Image Guidance
Phase III Study of PET-Directed Local or Systemic Therapy Intensification in Prostate Cancer Patients with Post-Prostatectomy Biochemical Recurrence
NRG-BN012: A Randomized Phase III Trial of Pre-Operative Compared to Post-Operative Stereotactic Radiosurgery in Patients With Resectable Brain Metastases
NRG-LU008: Phase III Prospective Randomized Trial Of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed By Concurrent Mediastinal Chemoradiation For Locally Advanced Non-Small Cell Lung Cancer
Parallel Phase III Randomized Trials for High Risk Prostate Cancer Evaluating De-Intensification for Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk with Radiation (PREDICT-RT*)
Randomized Phase III Trial Incorporating Abiraterone Acetate with Prednisone and Apalutamide and Advanced Imaging Into Salvage Treatment for Patients with Node-Positive Prostate Cancer After Radical Prostatectomy
Parallel Phase III Randomized Trials of Genomic-Risk Stratified Unfavorable Intermediate Risk Prostate Cancer: De-Intensification and Intensification Clinical Trial Evaluation (GUIDANCE)
S1914 A Randomized Phase III Trial of Induction/Consolidation Atezolizumab (NSC #783608) + SBRT versus SBRT Alone in High Risk, Early Stage NSCLC
NRG-LU007 Randomized Phase II/III Trial Of Consolidation Radiation + Immunotherapy for ES-SCLC: RAPTOR trial

Recent Publications


Wolfe, S, Diven, MA, Marciscano, AE, Zhou, XK, Kishan, AU, Steinberg, ML, Miccio, JA, Camilleri, P & Nagar, H 2023, 'A randomized phase II trial of MR-guided prostate stereotactic body radiotherapy administered in 5 or 2 fractions for localized prostate cancer (FORT)', BMC Cancer, vol. 23, no. 1, 923.
Lorenz, FJ, Mahase, SS, Miccio, J, King, TS, Pradhan, S & Goyal, N 2023, 'Update on adherence to guidelines for time to initiation of postoperative radiation for head and neck squamous cell carcinoma', Head and Neck, vol. 45, no. 7, pp. 1676-1691.


Oladeru, OT, Ma, SJ, Miccio, JA, Wang, K, Attwood, K, Singh, AK, Haas-Kogan, DA & Neira, PM 2022, 'Breast and Cervical Cancer Screening Disparities in Transgender People', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 45, no. 3, pp. 116-121.
Mokhtech, M, Miccio, JA, Johung, K, Cecchini, M, Stein, S, Narang, AK, Herman, JM, Kunstman, J, Haddock, MG, Anker, CJ, Jabbour, S, Hallemeier, CL & Jethwa, KR 2022, 'Multiagent Chemotherapy Followed by Stereotactic Body Radiotherapy Versus Conventional Radiotherapy for Resected Pancreas Cancer', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 45, no. 11, pp. 450-457.
Gao, SJ, Jin, L, Meadows, HW, Shafman, TD, Gross, CP, Yu, JB, Aerts, HJWL, Miccio, JA, Stahl, JM, Mak, RH, Decker, RH & Kann, BH 2023, 'Prediction of Distant Metastases After Stereotactic Body Radiation Therapy for Early Stage NSCLC: Development and External Validation of a Multi-Institutional Model', Journal of Thoracic Oncology, vol. 18, no. 3, pp. 339-349.


Guo, Y, Czeyda-Pommersheim, F, Miccio, JA, Mahalingam, S, Cecchini, M & Pahade, J 2021, 'Can a simplified CT response criteria for vascular involvement in pancreatic adenocarcinoma after neoadjuvant therapy predict survival in patients who achieved subsequent R0 resection?', Abdominal Radiology, vol. 46, no. 12, pp. 5609-5617.
Patel, T, Miccio, J, Cecchini, M, Srikumar, T, Stein, S, Kortmanksy, J, Johung, K & Lacy, J 2021, 'Clinical outcomes of first line FOLFIRINOX vs. gemcitabine plus nab-paclitaxel in metastatic pancreatic cancer at the Yale Smilow Hospital System', Journal of Gastrointestinal Oncology, vol. 13, no. 6, pp. 2547-2556.
Lee, NCJ, Eskander, A, Miccio, JA, Park, HS, Shah, C, Rutenberg, M, Hosni, A & Husain, ZA 2021, 'Evaluation of head and neck soft tissue sarcoma 8th edition pathologic staging system and proposal of a novel stage grouping system', Oral Oncology, vol. 114, 105137.
Miccio, JA, Talcott, WJ, Patel, T, Park, HS, Cecchini, M, Salem, RR, Khan, SA, Stein, S, Kortmansky, JS, Lacy, J, Narang, A, Herman, J, Jabbour, SK, Hallemeier, CL, Johung, K & Jethwa, KR 2021, 'Margin negative resection and pathologic downstaging with multiagent chemotherapy with or without radiotherapy in patients with localized pancreas cancer: A national cancer database analysis', Clinical and Translational Radiation Oncology, vol. 27, pp. 15-23.
Yang, DX, Khera, R, Miccio, JA, Jairam, V, Chang, E, Yu, JB, Park, HS, Krumholz, HM & Aneja, S 2021, 'Prevalence of Missing Data in the National Cancer Database and Association with Overall Survival', JAMA network open, vol. 4, no. 3, e211793.
Peters, GW, Tao, W, Wei, W, Miccio, JA, Jethwa, KR, Cecchini, M & Johung, KL 2021, 'Publication Bias in Gastrointestinal Oncology Trials Performed over the Past Decade', Oncologist, vol. 26, no. 8, pp. 660-667.
Miccio, JA, Talcott, WJ, Jairam, V, Park, HS, Yu, JB, Leapman, MS, Johnson, SB, King, MT, Nguyen, PL & Kann, BH 2021, 'Quantifying treatment selection bias effect on survival in comparative effectiveness research: findings from low-risk prostate cancer patients', Prostate Cancer and Prostatic Diseases, vol. 24, no. 2, pp. 414-422.
Talcott, WJ, Miccio, JA, Park, HS, White, AA, Kozono, DE, Singer, L, Sands, JM, Sholl, LM, Detterbeck, FC, Mak, RH, Decker, RH & Kann, BH 2021, 'Rates of invasive disease and outcomes in NSCLC patients with biopsy suggestive of carcinoma in situ', Lung Cancer, vol. 157, pp. 17-20.


Cecchini, M, Miccio, JA, Pahade, J, Lacy, J, Salem, RR, Johnson, SB, Blakaj, A, Stein, S, Kortmansky, JS & Johung, KL 2020, 'A Single-Institution Experience of Induction 5-Fluorouracil, Leucovorin, Irinotecan, and Oxaliplatin Followed by Surgery Versus Consolidative Radiation for Borderline and Locally Advanced Unresectable Pancreatic Cancer', Pancreas, vol. 49, no. 7, pp. 904-911.
Patel, R, Ludmir, EB, Miccio, JA, Menon, H, Barsky, AR, Mesko, SM, Kodali, M, Lautenschlaeger, T, Adeberg, S, Simone, CB & Verma, V 2020, 'Disease-Related Outcomes and Toxicities of Intensity Modulated Radiation Therapy After Lung-Sparing Pleurectomy for Malignant Pleural Mesothelioma: A Systematic Review', Practical Radiation Oncology, vol. 10, no. 6, pp. 423-433.
Miccio, JA, Barsky, A, Gao, S, Verma, V, Noticewala, SS, Jairam, V, Johnson, SB, Yu, JB, Hansen, JE, Aneja, S, An, Y, Decker, RH, Omay, SB, Li, J, Kurtz, GA, Alonso-Basanta, M, Lee, JYK, Chiang, VL & Park, HS 2020, 'Multi-institutional retrospective review of stereotactic radiosurgery for brain metastasis in patients with small-cell lung cancer without prior brain-directed radiotherapy', Journal of Radiosurgery and SBRT, vol. 7, no. 1, pp. 19-27.
Oladeru, OT, Yang, DD, Ma, SJ, Miccio, JA, Orio, PF & Warren, LE 2020, 'Patterns of care and predictors of adjuvant radiation therapy in phyllodes tumor of the breast', Breast Journal, vol. 26, no. 7, pp. 1352-1357.
Miccio, JA, Oladeru, OT, Jun Ma, S & Johung, KL 2020, 'Radiation Therapy for Patients with Advanced Renal Cell Carcinoma', Urologic Clinics of North America, vol. 47, no. 3, pp. 399-411.