Nuno Raimundo, PhD - Penn State Cancer Institute
Researcher Profile
Nuno Raimundo, PhD
Associate Professor, Department of Cell and Biological Systems
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2026
Aveleira, C, Martial, T, Carrique, L, Gaspar, R, Caulino-Rocha, A, Myatt, I, Wendler, F, Lascaux, P, Le Claire, M, Bancroft, J, Smythe, C, Ramadan, K, Raimundo, N & Milosevic, I 2026, 'Dynamins maintain nuclear envelope homeostasis and genome stability', Nature communications, vol. 17, no. 1, 1380. https://doi.org/10.1038/s41467-025-68130-4
Dias, RA, Mendes, C, Raimundo, N & Domingues, N 2026, Neuroprotection and antiaging effects of caloric restriction. in Nutritional Neuroscience: From Bench to Bedside. Elsevier, pp. 221-233. https://doi.org/10.1016/B978-0-443-33841-0.00023-3
2025
Domingues, N, Calcagni’, A, Freire, S, Pires, J, Casqueiro, R, Salazar, IL, Herz, NJ, Huynh, T, Wieciorek, K, Outeiro, TF, Girão, H, Milosevic, I, Ballabio, A & Raimundo, N 2025, 'Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling', EMBO Reports, vol. 26, no. 24, pp. 6096-6120. https://doi.org/10.1038/s44319-025-00613-3
Rogina, B, Anderson, R, Lebrasseur, NK, Curran, SP, Yousefzadeh, MJ, Ghosh, B, Duque, G, Howlett, S, Austad, S, Demuth, I, Gerstorf, D, Korfhage, J, Lombard, DB, Abadir, P, Christensen, K, Carey, JR, Alberts, SC, Campos, F, Palavicini, JP, Palmer, A, Bell, J, Basisty, N, De Cabo, R, Gomes, A, Dixit, VD, Sen, P, Baur, JA, Imai, SI, Li, X, Valdez, G, Orr, ME, Pletcher, S, Andersen, J, Jones, L, Castillo-Azofeida, D, Bonaguidi, M, Suh, Y, Duncan, FE, Murray, A, Wang, MC, Burkewitz, K, Henne, M, Zhou, K, Bouhrara, M, Benjamini, D, Kolind, S, Walker, KA, Reiter, DA, Dean, DC, Gorbunova, V, Gladyshev, VN, Palovics, R, Niedernhofer, LJ, Fan, R, Bueckle, AD, Hurley, J, Esser, KA, Kapahi, P, Sato, S, Jiang, N, Ashiqueali, SA, Diaz, J, Mishra, SP, Raimundo, N, Banarjee, R, Allsopp, R, Reynolds, LM, Zhang, B, Sebastiani, P, Monti, S, Schork, N & Rappaport, N 2025, 'Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 80, no. 5, glaf026. https://doi.org/10.1093/gerona/glaf026
Teixeira, J, Benfeito, S, Carreira, R, Barbosa, A, Amorim, R, Tavares, LC, Jones, JG, Raimundo, N, Cagide, F, Oliveira, C, Borges, F, Koopman, WJH & Oliveira, PJ 2025, 'The mitochondriotropic antioxidants AntiOxBEN2 and AntiOxCIN4 are structurally-similar but differentially alter energy homeostasis in human skin fibroblasts', Biochimica et Biophysica Acta - Bioenergetics, vol. 1866, no. 2, 149535. https://doi.org/10.1016/j.bbabio.2025.149535
Dionísio, PA, Sardão, VA & Raimundo, N 2025, Understanding Mitochondrial and Lysosomal Dynamics by Fluorescent Microscopy. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2878, Humana Press Inc., pp. 211-221. https://doi.org/10.1007/978-1-0716-4264-1_11
2024
Domingues, N, Catarino, S, Cristóvão, B, Rodrigues, L, Carvalho, FA, Sarmento, MJ, Zuzarte, M, Almeida, J, Ribeiro-Rodrigues, T, Correia-Rodrigues, Â, Fernandes, F, Rodrigues-Santos, P, Aasen, T, Santos, NC, Korolchuk, VI, Gonçalves, T, Milosevic, I, Raimundo, N & Girão, H 2024, 'Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling', EMBO Journal, vol. 43, no. 17, pp. 3627-3649. https://doi.org/10.1038/s44318-024-00177-3
Lopes, C & Raimundo, N 2024, Mitochondria-Lysosome Crosstalk, in Disease and in Health. in The Dynamic Nature of Mitochondria: From Ultrastructure to Health and Disease. CRC Press, pp. 96-107. https://doi.org/10.1201/9781003221180-9
Agostini, F & Raimundo, N 2024, Mitochondrial quality control and the microphthalmia/transcription factor E (MiTF/TFE) family. in Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities. Elsevier, pp. 277-289. https://doi.org/10.1016/B978-0-443-15260-3.00003-X
Domingues, N, Pires, J, Milosevic, I & Raimundo, N 2025, 'Role of lipids in interorganelle communication', Trends in Cell Biology, vol. 35, no. 1, pp. 46-58. https://doi.org/10.1016/j.tcb.2024.04.008
Lascaux, P, Hoslett, G, Tribble, S, Trugenberger, C, Antičević, I, Otten, C, Torrecilla, I, Koukouravas, S, Zhao, Y, Yang, H, Aljarbou, F, Ruggiano, A, Song, W, Peron, C, Deangeli, G, Domingo, E, Bancroft, J, Carrique, L, Johnson, E, Vendrell, I, Fischer, R, Ng, AWT, Ngeow, J, D'Angiolella, V, Raimundo, N, Maughan, T, Popović, M, Milošević, I & Ramadan, K 2024, 'TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival', Cell, vol. 187, no. 20, pp. 5698-5718.e26. https://doi.org/10.1016/j.cell.2024.08.020
Agostini, F, Pereyra, L, Dale, J, Yambire, KF, Maglioni, S, Schiavi, A, Ventura, N, Milosevic, I & Raimundo, N 2024, 'Upregulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain', Journal of Biological Chemistry, vol. 300, no. 7, 107403. https://doi.org/10.1016/j.jbc.2024.107403
2023
Beatriz, M, Rodrigues, RJ, Vilaça, R, Egas, C, Pinheiro, PS, Daley, GQ, Schlaeger, TM, Raimundo, N, Rego, AC & Lopes, C 2023, 'Extracellular vesicles improve GABAergic transmission in Huntington’s disease iPSC-derived neurons', Theranostics, vol. 13, no. 11, pp. 3707-3724. https://doi.org/10.7150/thno.81981
Musa, M, Dionisio, PA, Casqueiro, R, Milosevic, I, Raimundo, N & Krisko, A 2023, 'Lack of peroxisomal catalase affects heat shock response in Caenorhabditis elegans', Life Science Alliance, vol. 6, no. 1. https://doi.org/10.26508/lsa.202201737
2022
Riera-Tur, I, Schäfer, T, Hornburg, D, Mishra, A, Da Silva Padilha, M, Fernández-Mosquera, L, Feigenbutz, D, Auer, P, Mann, M, Baumeister, W, Klein, R, Meissner, F, Raimundo, N, Fernández-Busnadiego, R & Dudanova, I 2022, 'Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity', Life Science Alliance, vol. 5, no. 3, e202101185. https://doi.org/10.26508/lsa.202101185
Carvalho, C, Pires, JF, Moreira, PI & Raimundo, N 2022, Disrupted cellular quality control mechanisms in aging. in Aging: From Fundamental Biology to Societal Impact. Elsevier, pp. 359-384. https://doi.org/10.1016/B978-0-12-823761-8.00016-1
Raimundo, N 2022, 'Feeding and lipophagy: it takes guts to deliver', EMBO Journal, vol. 41, no. 17, e112180. https://doi.org/10.15252/embj.2022112180
Deus, CM, Teixeira, J, Raimundo, N, Tucci, P, Borges, F, Saso, L & Oliveira, PJ 2022, 'Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease', European Journal of Clinical Investigation, vol. 52, no. 10, e13820. https://doi.org/10.1111/eci.13820
Maglioni, S, Schiavi, A, Melcher, M, Brinkmann, V, Luo, Z, Laromaine, A, Raimundo, N, Meyer, JN, Distelmaier, F & Ventura, N 2022, 'Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans', Nature communications, vol. 13, no. 1, 2620. https://doi.org/10.1038/s41467-022-29972-4