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Ibrahim Tarik Ozbolat, PhD

Ibrahim Tarik Ozbolat, PhD

Professor, Engineering Science and Mechanics
Professor, Department of Neurosurgery
Center for Neural Engineering
Scientific Program:Mechanisms of Carcinogenesis
ITO1@psu.edu

Research Interests

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  • Bioprinting
  • Tissue Engineering
  • Bone and Bones
  • Technology
  • Stem Cells
  • Blood Vessels
  • Printing
  • Alginates
  • Cartilage
  • Collagen
  • Biocompatible Materials
  • Tissue Scaffolds
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Recent Publications

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2024

Xie, R, Pal, V, Yu, Y, Lu, X, Gao, M, Liang, S, Huang, M, Peng, W & Ozbolat, IT 2024, 'A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications', Biomaterials, vol. 304, 122408. https://doi.org/10.1016/j.biomaterials.2023.122408
Wu, Y, Yang, X, Gupta, D, Alioglu, MA, Qin, M, Ozbolat, V, Li, Y & Ozbolat, IT 2024, 'Dissecting the Interplay Mechanism among Process Parameters toward the Biofabrication of High-Quality Shapes in Embedded Bioprinting', Advanced Functional Materials. https://doi.org/10.1002/adfm.202313088
Kang, Y, Yeo, M, Derman, ID, Ravnic, DJ, Singh, YP, Alioglu, MA, Wu, Y, Makkar, J, Driskell, RR & Ozbolat, IT 2024, 'Intraoperative bioprinting of human adipose-derived stem cells and extra-cellular matrix induces hair follicle-like downgrowths and adipose tissue formation during full-thickness craniomaxillofacial skin reconstruction', Bioactive Materials, vol. 33, pp. 114-128. https://doi.org/10.1016/j.bioactmat.2023.10.034
Yeo, M, Sarkar, A, Singh, YP, Derman, ID, Datta, P & Ozbolat, IT 2024, 'Synergistic coupling between 3D bioprinting and vascularization strategies', Biofabrication, vol. 1, no. 12003, 012003. https://doi.org/10.1088/1758-5090/ad0b3f

2023

Alioglu, MA, Singh, YP, Nagamine, M, Rizvi, SHA, Pal, V, Gerhard, EM, Saini, S, Kim, MH & Ozbolat, IT 2023, '3D embedded printing of microfluidic devices using a functional silicone composite support bath', Additive Manufacturing, vol. 70, 103566. https://doi.org/10.1016/j.addma.2023.103566
Alioglu, MA, Yilmaz, YO, Gerhard, EM, Pal, V, Gupta, D, Rizvi, SHA & Ozbolat, IT 2024, 'A Versatile Photocrosslinkable Silicone Composite for 3D Printing Applications', Advanced Materials Technologies, vol. 9, no. 3, 2301858. https://doi.org/10.1002/admt.202301858
Asim, S, Tabish, TA, Liaqat, U, Ozbolat, IT & Rizwan, M 2023, 'Advances in Gelatin Bioinks to Optimize Bioprinted Cell Functions', Advanced Healthcare Materials, vol. 12, no. 17, 2203148. https://doi.org/10.1002/adhm.202203148
Ozbolat, IT 2023, 'Advancing the field of 3D bioprinting: an interview with Ibrahim T Ozbolat', Journal of 3D Printing in Medicine, vol. 7, no. 3, 3DP012. https://doi.org/10.2217/3dp-2023-0010
Derman, ID, Singh, YP, Saini, S, Nagamine, M, Banerjee, D & Ozbolat, IT 2023, 'Bioengineering and Clinical Translation of Human Lung and its Components', Advanced Biology, vol. 7, no. 4, 2200267. https://doi.org/10.1002/adbi.202200267
Banerjee, D, Ivanova, MM, Celik, N, Kim, MH, Derman, ID, Limgala, RP, Ozbolat, IT & Goker-Alpan, O 2023, 'Biofabrication of an in-vitro bone model for Gaucher disease', Biofabrication, vol. 15, no. 4, 045023. https://doi.org/10.1088/1758-5090/acf95a
Moncal, KK, Yeo, M, Celik, N, Acri, TM, Rizk, E, Wee, H, Lewis, GS, Salem, AK & Ozbolat, IT 2023, 'Comparison of in-situ versus ex-situ delivery of polyethylenimine-BMP-2 polyplexes for rat calvarial defect repair via intraoperative bioprinting', Biofabrication, vol. 15, no. 1, 015011. https://doi.org/10.1088/1758-5090/ac9f70
Gupta, D, Chichkov, B, Vereb, ZJ & Ozbolat, IT 2023, 'Editorial: Innovative 3D technologies in cancer immunity research and therapy', Frontiers in immunology, vol. 14, 1235483. https://doi.org/10.3389/fimmu.2023.1235483
Tuftee, C, Alsberg, E, Ozbolat, IT & Rizwan, M 2024, 'Emerging granular hydrogel bioinks to improve biological function in bioprinted constructs', Trends in Biotechnology, vol. 42, no. 3, pp. 339-352. https://doi.org/10.1016/j.tibtech.2023.09.007
Deniz Derman, I, Yeo, M, Castaneda, DC, Callender, M, Horvath, M, Mo, Z, Xiong, R, Fleming, E, Chen, P, Peeples, ME, Palucka, K, Oh, J & Ozbolat, IT 2023, 'High-throughput bioprinting of the nasal epithelium using patient-derived nasal epithelial cells', Biofabrication, vol. 15, no. 4, 044103. https://doi.org/10.1088/1758-5090/aced23
Pal, V, Singh, YP, Gupta, D, Alioglu, MA, Nagamine, M, Kim, MH & Ozbolat, IT 2023, 'High-throughput microgel biofabrication via air-assisted co-axial jetting for cell encapsulation, 3D bioprinting, and scaffolding applications', Biofabrication, vol. 15, no. 3, 035001. https://doi.org/10.1088/1758-5090/acc4eb
Alioglu, MA, Yilmaz, YO, Singh, YP, Nagamine, M, Celik, N, Kim, MH, Pal, V, Gupta, D & Ozbolat, IT 2023, 'Nested Biofabrication: Matryoshka-Inspired Intra-Embedded Bioprinting', Small Methods. https://doi.org/10.1002/smtd.202301325

2022

Wu, Y, Fuh, J & Ozbolat, IT 2022, 3D Bioprinting in Tissue and Organ Regeneration. Elsevier.
Shyam Mohan, T, Datta, P, Nesaei, S, Ozbolat, V & Ozbolat, IT 2022, '3D coaxial bioprinting: Process mechanisms, bioinks and applications', Progress in Biomedical Engineering, vol. 4, no. 2, 022003. https://doi.org/10.1088/2516-1091/ac631c
Kim, MH, Banerjee, D, Celik, N & Ozbolat, IT 2022, 'Aspiration-assisted freeform bioprinting of mesenchymal stem cell spheroids within alginate microgels', Biofabrication, vol. 14, no. 2, 024103. https://doi.org/10.1088/1758-5090/ac4dd8
Dey, M, Kim, MH, Nagamine, M, Karhan, E, Kozhaya, L, Dogan, M, Unutmaz, D & Ozbolat, IT 2022, 'Biofabrication of 3D breast cancer models for dissecting the cytotoxic response of human T cells expressing engineered MAIT cell receptors', Biofabrication, vol. 14, no. 4, 044105. https://doi.org/10.1088/1758-5090/ac925a
Dey, M, Kim, MH, Dogan, M, Nagamine, M, Kozhaya, L, Celik, N, Unutmaz, D & Ozbolat, IT 2022, 'Chemotherapeutics and CAR-T Cell-Based Immunotherapeutics Screening on a 3D Bioprinted Vascularized Breast Tumor Model', Advanced Functional Materials, vol. 32, no. 52, 2203966. https://doi.org/10.1002/adfm.202203966
Moncal, KK, Tigli Aydın, RS, Godzik, KP, Acri, TM, Heo, DN, Rizk, E, Wee, H, Lewis, GS, Salem, AK & Ozbolat, IT 2022, 'Controlled Co-delivery of pPDGF-B and pBMP-2 from intraoperatively bioprinted bone constructs improves the repair of calvarial defects in rats', Biomaterials, vol. 281, 121333. https://doi.org/10.1016/j.biomaterials.2021.121333
Hospodiuk-Karwowski, M, Bokhari, SMQ, Chi, K, Moncal, KK, Ozbolat, V, Ozbolat, IT & Catchmark, JM 2022, 'Dual-charge bacterial cellulose as a potential 3D printable material for soft tissue engineering', Composites Part B: Engineering, vol. 231, 109598. https://doi.org/10.1016/j.compositesb.2021.109598
Datta, P, Cabrera, LY & Ozbolat, IT 2023, 'Ethical challenges with 3D bioprinted tissues and organs', Trends in Biotechnology, vol. 41, no. 1, pp. 6-9. https://doi.org/10.1016/j.tibtech.2022.08.012
McLaughlin, C, Datta, P, Singh, YP, Lo, A, Horchler, S, Elcheva, IA, Ozbolat, IT, Ravnic, DJ & Koduru, SV 2022, 'Mesenchymal Stem Cell-Derived Extracellular Vesicles for Therapeutic Use and in Bioengineering Applications', Cells, no. 21, 3366. https://doi.org/10.3390/cells11213366
Banerjee, D, Singh, YP, Datta, P, Ozbolat, V, O'Donnell, A, Yeo, M & Ozbolat, IT 2022, 'Strategies for 3D bioprinting of spheroids: A comprehensive review', Biomaterials, vol. 291, 121881. https://doi.org/10.1016/j.biomaterials.2022.121881
Celik, N, Kim, MH, Yeo, M, Kamal, F, Hayes, DJ & Ozbolat, IT 2022, 'miRNA induced 3D bioprinted-heterotypic osteochondral interface', Biofabrication, vol. 14, no. 4, 044104. https://doi.org/10.1088/1758-5090/ac7fbb

2021

Kabir, A, Datta, P, Oh, J, Williams, A, Ozbolat, V, Unutmaz, D & Ozbolat, IT 2021, '3D Bioprinting for fabrication of tissue models of COVID-19 infection', Essays in biochemistry, vol. 65, no. 3, pp. 503-518. https://doi.org/10.1042/EBC20200129
Datta, P, Wu, Y, Yu, Y, Moncal, KK & Ozbolat, IT 2021, A Scaffold Free 3D Bioprinted Cartilage Model for In Vitro Toxicology. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2147, Humana Press Inc., pp. 175-183. https://doi.org/10.1007/978-1-0716-0611-7_15
Heo, DN, Ayan, B, Dey, M, Banerjee, D, Wee, H, Lewis, GS & Ozbolat, IT 2021, 'Aspiration-assisted bioprinting of co-cultured osteogenic spheroids for bone tissue engineering', Biofabrication, vol. 13, no. 1, 015013. https://doi.org/10.1088/1758-5090/abc1bf
Zhou, K, Dey, M, Ayan, B, Zhang, Z, Ozbolat, V, Kim, MH, Khristov, V & Ozbolat, IT 2021, 'Fabrication of PDMS microfluidic devices using nanoclay-reinforced Pluronic F-127 as a sacrificial ink', Biomedical Materials (Bristol), vol. 16, no. 4, 045005. https://doi.org/10.1088/1748-605X/abe55e
Moncal, KK, Gudapati, H, Godzik, KP, Heo, DN, Kang, Y, Rizk, E, Ravnic, DJ, Wee, H, Pepley, DF, Ozbolat, V, Lewis, GS, Moore, JZ, Driskell, RR, Samson, TD & Ozbolat, IT 2021, 'Intra-Operative Bioprinting of Hard, Soft, and Hard/Soft Composite Tissues for Craniomaxillofacial Reconstruction', Advanced Functional Materials, vol. 31, no. 29, 2010858. https://doi.org/10.1002/adfm.202010858
Celik, N, Kim, MH, Hayes, DJ & Ozbolat, IT 2021, 'MiRNA induced co-differentiation and cross-talk of adipose tissue-derived progenitor cells for 3D heterotypic pre-vascularized bone formation', Biofabrication, vol. 13, no. 4, 044107. https://doi.org/10.1088/1758-5090/ac23ae
Khoeini, R, Nosrati, H, Akbarzadeh, A, Eftekhari, A, Kavetskyy, T, Khalilov, R, Ahmadian, E, Nasibova, A, Datta, P, Roshangar, L, Deluca, DC, Davaran, S, Cucchiarini, M & Ozbolat, IT 2021, 'Natural and Synthetic Bioinks for 3D Bioprinting', Advanced NanoBiomed Research, vol. 1, no. 8, 2000097. https://doi.org/10.1002/anbr.202000097
Koduru, SV, Leberfinger, AN, Ozbolat, IT & Ravnic, DJ 2021, 'Navigating the Genomic Landscape of Human Adipose Stem Cell-Derived β-Cells', Stem Cells and Development, vol. 30, no. 23, pp. 1153-1170. https://doi.org/10.1089/scd.2021.0160
Landay, A, Bartley, JM, Banerjee, D, Hargis, G, Haynes, L, Keshavarzian, A, Kuo, CL, Kwon, OS, Li, S, Li, S, Oh, J, Ozbolat, IT, Ucar, D, Xu, M, Yao, X, Unutmaz, D & Kuchel, GA 2021, 'Network Topology of Biological Aging and Geroscience-Guided Approaches to COVID-19', Frontiers in Aging, vol. 2, 695218. https://doi.org/10.3389/fragi.2021.695218
Agarwal, T, Banerjee, D, Konwarh, R, Esworthy, T, Kumari, J, Onesto, V, Das, P, Lee, BH, Wagener, FADTG, Makvandi, P, Mattoli, V, Ghosh, SK, Maiti, TK, Zhang, LG & Ozbolat, IT 2021, 'Recent advances in bioprinting technologies for engineering hepatic tissue', Materials Science and Engineering C, vol. 123, 112013. https://doi.org/10.1016/j.msec.2021.112013
Dey, M, Ayan, B, Yurieva, M, Unutmaz, D & Ozbolat, IT 2021, 'Studying Tumor Angiogenesis and Cancer Invasion in a Three-Dimensional Vascularized Breast Cancer Micro-Environment', Advanced Biology, vol. 5, no. 7, 2100090. https://doi.org/10.1002/adbi.202100090

2020

Heo, DN, Alioglu, MA, Wu, Y, Ozbolat, V, Ayan, B, Dey, M, Kang, Y & Ozbolat, IT 2020, '3D Bioprinting of Carbohydrazide-Modified Gelatin into Microparticle-Suspended Oxidized Alginate for the Fabrication of Complex-Shaped Tissue Constructs', ACS Applied Materials and Interfaces, vol. 12, no. 18, pp. 20295-20306. https://doi.org/10.1021/acsami.0c05096
Kang, Y, Datta, P, Shanmughapriya, S & Ozbolat, IT 2020, '3D Bioprinting of Tumor Models for Cancer Research', ACS Applied Bio Materials, vol. 3, no. 9, pp. 5552-5573. https://doi.org/10.1021/acsabm.0c00791
Wu, Y, Zhang, Y, Yu, Y & Ozbolat, IT 2020, 3D Coaxial Bioprinting of Vasculature. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2140, Humana Press Inc., pp. 171-181. https://doi.org/10.1007/978-1-0716-0520-2_11
Datta, P, Dey, M, Ataie, Z, Unutmaz, D & Ozbolat, IT 2020, '3D bioprinting for reconstituting the cancer microenvironment', npj Precision Oncology, vol. 4, no. 1, 18. https://doi.org/10.1038/s41698-020-0121-2
Dey, M & Ozbolat, IT 2020, '3D bioprinting of cells, tissues and organs', Scientific reports, vol. 10, no. 1, 14023. https://doi.org/10.1038/s41598-020-70086-y
Ayan, B, Heo, DN, Zhang, Z, Dey, M, Povilianskas, A, Drapaca, C & Ozbolat, IT 2020, 'Aspiration-assisted bioprinting for precise positioning of biologics', Science Advances, vol. 6, no. 10, eaaw5111. https://doi.org/10.1126/sciadv.aaw5111
Ayan, B, Wu, Y, Karuppagounder, V, Kamal, F & Ozbolat, IT 2020, 'Aspiration-assisted bioprinting of the osteochondral interface', Scientific reports, vol. 10, no. 1, 13148. https://doi.org/10.1038/s41598-020-69960-6
Ayan, B, Celik, N, Zhang, Z, Zhou, K, Kim, MH, Banerjee, D, Wu, Y, Costanzo, F & Ozbolat, IT 2020, 'Aspiration-assisted freeform bioprinting of pre-fabricated tissue spheroids in a yield-stress gel', Communications Physics, vol. 3, no. 1, 183. https://doi.org/10.1038/s42005-020-00449-4
Wu, Y, Ayan, B, Moncal, KK, Kang, Y, Dhawan, A, Koduru, SV, Ravnic, DJ, Kamal, F & Ozbolat, IT 2020, 'Hybrid Bioprinting of Zonally Stratified Human Articular Cartilage Using Scaffold-Free Tissue Strands as Building Blocks', Advanced Healthcare Materials, vol. 9, no. 22, 2001657. https://doi.org/10.1002/adhm.202001657
Wu, Y, Ravnic, DJ & Ozbolat, IT 2020, 'Intraoperative Bioprinting: Repairing Tissues and Organs in a Surgical Setting', Trends in Biotechnology, vol. 38, no. 6, pp. 594-605. https://doi.org/10.1016/j.tibtech.2020.01.004
Gudapati, H, Parisi, D, Colby, RH & Ozbolat, IT 2020, 'Rheological investigation of collagen, fibrinogen, and thrombin solutions for drop-on-demand 3D bioprinting', Soft matter, vol. 16, no. 46, pp. 10506-10517. https://doi.org/10.1039/d0sm01455a
Gudapati, H & Ozbolat, IT 2020, 'The Role of Concentration on Drop Formation and Breakup of Collagen, Fibrinogen, and Thrombin Solutions during Inkjet Bioprinting', Langmuir, vol. 36, no. 50, pp. 15373-15385. https://doi.org/10.1021/acs.langmuir.0c02926
Sun, W, Starly, B, Daly, AC, Burdick, JA, Groll, J, Skeldon, G, Shu, W, Sakai, Y, Shinohara, M, Nishikawa, M, Jang, J, Cho, DW, Nie, M, Takeuchi, S, Ostrovidov, S, Khademhosseini, A, Kamm, RD, Mironov, V, Moroni, L & Ozbolat, IT 2020, 'The bioprinting roadmap', Biofabrication, vol. 12, no. 2, 022002. https://doi.org/10.1088/1758-5090/ab5158
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