Researcher Profile

Researcher Profile

Ibrahim Tarik Ozbolat, PhD

Ibrahim Tarik Ozbolat, PhD

Professor, Engineering Science and Mechanics
Professor, Department of Neurosurgery
Center for Neural Engineering
Scientific Program:Mechanisms of Carcinogenesis
ito1@psu.edu

Research Interests

  • Bioprinting
  • Bone and Bones
  • Tissue Engineering
  • Stem Cells
  • Technology
  • Cartilage
  • Printing
  • Tissue Scaffolds
  • Biocompatible Materials
  • Mesenchymal Stem Cells
  • Alginates
  • Biopharmaceutics

Recent Publications

2023

Moncal, KK, Yeo, M, Celik, N, Acri, TM, Rizk, E, Wee, H, Lewis, G, Salem, AK & Ozbolat, IT 2023, 'Comparison of in-situ versus ex-situ delivery of polyethylenimine-BMP-2 polyplexes for rat calvarial defect repair via intraoperative bioprinting', Biofabrication, vol. 15, no. 1, 015011. https://doi.org/10.1088/1758-5090/ac9f70

2022

Wu, Y, Fuh, J & Ozbolat, IT 2022, 3D Bioprinting in Tissue and Organ Regeneration. Elsevier.
Shyam Mohan, T, Datta, P, Nesaei, S, Ozbolat, V & Ozbolat, IT 2022, '3D coaxial bioprinting: Process mechanisms, bioinks and applications', Progress in Biomedical Engineering, vol. 4, no. 2, 022003. https://doi.org/10.1088/2516-1091/ac631c
Kim, MH, Banerjee, D, Celik, N & Ozbolat, IT 2022, 'Aspiration-assisted freeform bioprinting of mesenchymal stem cell spheroids within alginate microgels', Biofabrication, vol. 14, no. 2, 024103. https://doi.org/10.1088/1758-5090/ac4dd8
Dey, M, Kim, MH, Nagamine, M, Karhan, E, Kozhaya, L, Dogan, M, Unutmaz, D & Ozbolat, IT 2022, 'Biofabrication of 3D breast cancer models for dissecting the cytotoxic response of human T cells expressing engineered MAIT cell receptors', Biofabrication, vol. 14, no. 4, 044105. https://doi.org/10.1088/1758-5090/ac925a
Dey, M, Kim, MH, Dogan, M, Nagamine, M, Kozhaya, L, Celik, N, Unutmaz, D & Ozbolat, IT 2022, 'Chemotherapeutics and CAR-T Cell-Based Immunotherapeutics Screening on a 3D Bioprinted Vascularized Breast Tumor Model', Advanced Functional Materials, vol. 32, no. 52, 2203966. https://doi.org/10.1002/adfm.202203966
Moncal, KK, Tigli Aydın, RS, Godzik, KP, Acri, TM, Heo, DN, Rizk, E, Wee, H, Lewis, GS, Salem, AK & Ozbolat, IT 2022, 'Controlled Co-delivery of pPDGF-B and pBMP-2 from intraoperatively bioprinted bone constructs improves the repair of calvarial defects in rats', Biomaterials, vol. 281, 121333. https://doi.org/10.1016/j.biomaterials.2021.121333
Hospodiuk-Karwowski, M, Bokhari, SMQ, Chi, K, Moncal, KK, Ozbolat, V, Ozbolat, IT & Catchmark, JM 2022, 'Dual-charge bacterial cellulose as a potential 3D printable material for soft tissue engineering', Composites Part B: Engineering, vol. 231, 109598. https://doi.org/10.1016/j.compositesb.2021.109598
Datta, P, Cabrera, LY & Ozbolat, IT 2023, 'Ethical challenges with 3D bioprinted tissues and organs', Trends in Biotechnology, vol. 41, no. 1, pp. 6-9. https://doi.org/10.1016/j.tibtech.2022.08.012
McLaughlin, C, Datta, P, Singh, YP, Lo, A, Horchler, S, Elcheva, IA, Ozbolat, IT, Ravnic, DJ & Koduru, SV 2022, 'Mesenchymal Stem Cell-Derived Extracellular Vesicles for Therapeutic Use and in Bioengineering Applications', Cells, no. 21, 3366. https://doi.org/10.3390/cells11213366
Banerjee, D, Singh, YP, Datta, P, Ozbolat, V, O'Donnell, A, Yeo, M & Ozbolat, IT 2022, 'Strategies for 3D bioprinting of spheroids: A comprehensive review', Biomaterials, vol. 291, 121881. https://doi.org/10.1016/j.biomaterials.2022.121881
Celik, N, Kim, MH, Yeo, M, Kamal, F, Hayes, DJ & Ozbolat, IT 2022, 'miRNA induced 3D bioprinted-heterotypic osteochondral interface', Biofabrication, vol. 14, no. 4, 044104. https://doi.org/10.1088/1758-5090/ac7fbb

2021

Kabir, A, Datta, P, Oh, J, Williams, A, Ozbolat, V, Unutmaz, D & Ozbolat, IT 2021, '3D Bioprinting for fabrication of tissue models of COVID-19 infection', Essays in biochemistry, vol. 65, no. 3, pp. 503-518. https://doi.org/10.1042/EBC20200129
Datta, P, Wu, Y, Yu, Y, Moncal, KK & Ozbolat, IT 2021, A Scaffold Free 3D Bioprinted Cartilage Model for In Vitro Toxicology. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2147, Humana Press Inc., pp. 175-183. https://doi.org/10.1007/978-1-0716-0611-7_15
Heo, DN, Ayan, B, Dey, M, Banerjee, D, Wee, H, Lewis, GS & Ozbolat, IT 2021, 'Aspiration-assisted bioprinting of co-cultured osteogenic spheroids for bone tissue engineering', Biofabrication, vol. 13, no. 1, 015013. https://doi.org/10.1088/1758-5090/abc1bf
Zhou, K, Dey, M, Ayan, B, Zhang, Z, Ozbolat, V, Kim, MH, Khristov, V & Ozbolat, IT 2021, 'Fabrication of PDMS microfluidic devices using nanoclay-reinforced Pluronic F-127 as a sacrificial ink', Biomedical Materials (Bristol), vol. 16, no. 4, 045005. https://doi.org/10.1088/1748-605X/abe55e
Moncal, KK, Gudapati, H, Godzik, KP, Heo, DN, Kang, Y, Rizk, E, Ravnic, DJ, Wee, H, Pepley, DF, Ozbolat, V, Lewis, GS, Moore, JZ, Driskell, RR, Samson, TD & Ozbolat, IT 2021, 'Intra-Operative Bioprinting of Hard, Soft, and Hard/Soft Composite Tissues for Craniomaxillofacial Reconstruction', Advanced Functional Materials, vol. 31, no. 29, 2010858. https://doi.org/10.1002/adfm.202010858
Celik, N, Kim, MH, Hayes, DJ & Ozbolat, IT 2021, 'MiRNA induced co-differentiation and cross-talk of adipose tissue-derived progenitor cells for 3D heterotypic pre-vascularized bone formation', Biofabrication, vol. 13, no. 4, 044107. https://doi.org/10.1088/1758-5090/ac23ae
Koduru, SV, Leberfinger, AN, Ozbolat, IT & Ravnic, DJ 2021, 'Navigating the Genomic Landscape of Human Adipose Stem Cell-Derived β-Cells', Stem Cells and Development, vol. 30, no. 23, pp. 1153-1170. https://doi.org/10.1089/scd.2021.0160
Agarwal, T, Banerjee, D, Konwarh, R, Esworthy, T, Kumari, J, Onesto, V, Das, P, Lee, BH, Wagener, FADTG, Makvandi, P, Mattoli, V, Ghosh, SK, Maiti, TK, Zhang, LG & Ozbolat, IT 2021, 'Recent advances in bioprinting technologies for engineering hepatic tissue', Materials Science and Engineering C, vol. 123, 112013. https://doi.org/10.1016/j.msec.2021.112013
Dey, M, Ayan, B, Yurieva, M, Unutmaz, D & Ozbolat, IT 2021, 'Studying Tumor Angiogenesis and Cancer Invasion in a Three-Dimensional Vascularized Breast Cancer Micro-Environment', Advanced Biology, vol. 5, no. 7, 2100090. https://doi.org/10.1002/adbi.202100090

2020

Heo, DN, Alioglu, MA, Wu, Y, Ozbolat, V, Ayan, B, Dey, M, Kang, Y & Ozbolat, IT 2020, '3D Bioprinting of Carbohydrazide-Modified Gelatin into Microparticle-Suspended Oxidized Alginate for the Fabrication of Complex-Shaped Tissue Constructs', ACS Applied Materials and Interfaces, vol. 12, no. 18, pp. 20295-20306. https://doi.org/10.1021/acsami.0c05096
Kang, Y, Datta, P, Shanmughapriya, S & Ozbolat, IT 2020, '3D Bioprinting of Tumor Models for Cancer Research', ACS Applied Bio Materials, vol. 3, no. 9, pp. 5552-5573. https://doi.org/10.1021/acsabm.0c00791
Wu, Y, Zhang, Y, Yu, Y & Ozbolat, IT 2020, 3D Coaxial Bioprinting of Vasculature. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2140, Humana Press Inc., pp. 171-181. https://doi.org/10.1007/978-1-0716-0520-2_11
Datta, P, Dey, M, Ataie, Z, Unutmaz, D & Ozbolat, IT 2020, '3D bioprinting for reconstituting the cancer microenvironment', npj Precision Oncology, vol. 4, no. 1, 18. https://doi.org/10.1038/s41698-020-0121-2
Dey, M & Ozbolat, IT 2020, '3D bioprinting of cells, tissues and organs', Scientific reports, vol. 10, no. 1, 14023. https://doi.org/10.1038/s41598-020-70086-y
Ayan, B, Heo, DN, Zhang, Z, Dey, M, Povilianskas, A, Drapaca, C & Ozbolat, IT 2020, 'Aspiration-assisted bioprinting for precise positioning of biologics', Science Advances, vol. 6, no. 10, eaaw5111. https://doi.org/10.1126/sciadv.aaw5111
Ayan, B, Wu, Y, Karuppagounder, V, Kamal, F & Ozbolat, IT 2020, 'Aspiration-assisted bioprinting of the osteochondral interface', Scientific reports, vol. 10, no. 1, 13148. https://doi.org/10.1038/s41598-020-69960-6
Ayan, B, Celik, N, Zhang, Z, Zhou, K, Kim, MH, Banerjee, D, Wu, Y, Costanzo, F & Ozbolat, IT 2020, 'Aspiration-assisted freeform bioprinting of pre-fabricated tissue spheroids in a yield-stress gel', Communications Physics, vol. 3, no. 1, 183. https://doi.org/10.1038/s42005-020-00449-4
Wu, Y, Ayan, B, Moncal, KK, Kang, Y, Dhawan, A, Koduru, SV, Ravnic, DJ, Kamal, F & Ozbolat, IT 2020, 'Hybrid Bioprinting of Zonally Stratified Human Articular Cartilage Using Scaffold-Free Tissue Strands as Building Blocks', Advanced Healthcare Materials, vol. 9, no. 22, 2001657. https://doi.org/10.1002/adhm.202001657
Wu, Y, Ravnic, DJ & Ozbolat, IT 2020, 'Intraoperative Bioprinting: Repairing Tissues and Organs in a Surgical Setting', Trends in Biotechnology, vol. 38, no. 6, pp. 594-605. https://doi.org/10.1016/j.tibtech.2020.01.004
Gudapati, H, Parisi, D, Colby, RH & Ozbolat, IT 2020, 'Rheological investigation of collagen, fibrinogen, and thrombin solutions for drop-on-demand 3D bioprinting', Soft matter, vol. 16, no. 46, pp. 10506-10517. https://doi.org/10.1039/d0sm01455a
Gudapati, H & Ozbolat, IT 2020, 'The Role of Concentration on Drop Formation and Breakup of Collagen, Fibrinogen, and Thrombin Solutions during Inkjet Bioprinting', Langmuir, vol. 36, no. 50, pp. 15373-15385. https://doi.org/10.1021/acs.langmuir.0c02926
Sun, W, Starly, B, Daly, AC, Burdick, JA, Groll, J, Skeldon, G, Shu, W, Sakai, Y, Shinohara, M, Nishikawa, M, Jang, J, Cho, DW, Nie, M, Takeuchi, S, Ostrovidov, S, Khademhosseini, A, Kamm, RD, Mironov, V, Moroni, L & Ozbolat, IT 2020, 'The bioprinting roadmap', Biofabrication, vol. 12, no. 2, 022002. https://doi.org/10.1088/1758-5090/ab5158

2019

Ulag, S, Kalkandelen, C, Oktar, FN, Uzun, M, Sahin, YM, Karademir, B, Arslan, S, Ozbolat, IT, Mahirogullari, M & Gunduz, O 2019, '3D Printing Artificial Blood Vessel Constructs Using PCL/Chitosan/Hydrogel Biocomposites', ChemistrySelect, vol. 4, no. 8, pp. 2387-2391. https://doi.org/10.1002/slct.201803740
Dodda, A, Wali, A, Wu, Y, Pannone, A, Reddy, LK, Raha, A, Ozdemir, SK, Ozbolat, IT & Das, S 2019, 'Biological One-Way Functions for Secure Key Generation', Advanced Theory and Simulations, vol. 2, no. 2, 1800154. https://doi.org/10.1002/adts.201800154
Wali, A, Dodda, A, Wu, Y, Pannone, A, Reddy Usthili, LK, Ozdemir, SK, Ozbolat, IT & Das, S 2019, 'Biological physically unclonable function', Communications Physics, vol. 2, no. 1, 39. https://doi.org/10.1038/s42005-019-0139-3
Leberfinger, AN, Dinda, S, Wu, Y, Koduru, SV, Ozbolat, V, Ravnic, DJ & Ozbolat, IT 2019, 'Bioprinting functional tissues', Acta Biomaterialia, vol. 95, pp. 32-49. https://doi.org/10.1016/j.actbio.2019.01.009
Koduru, SV, Leberfinger, AN, Pasic, D, Forghani, A, Lince, S, Hayes, DJ, Ozbolat, IT & Ravnic, DJ 2019, 'Cellular Based Strategies for Microvascular Engineering', Stem Cell Reviews and Reports, vol. 15, no. 2, pp. 218-240. https://doi.org/10.1007/s12015-019-09877-4
Moncal, KK, Aydin, RST, Abu-Laban, M, Heo, DN, Rizk, E, Tucker, SM, Lewis, GS, Hayes, D & Ozbolat, IT 2019, 'Collagen-infilled 3D printed scaffolds loaded with miR-148b-transfected bone marrow stem cells improve calvarial bone regeneration in rats', Materials Science and Engineering C, vol. 105, 110128. https://doi.org/10.1016/j.msec.2019.110128
Ozbolat, V, Dey, M, Ayan, B & Ozbolat, IT 2019, 'Extrusion-based printing of sacrificial Carbopol ink for fabrication of microfluidic devices', Biofabrication, vol. 11, no. 3, 034101. https://doi.org/10.1088/1758-5090/ab10ae
Wu, Y, Hospodiuk, M, Peng, W, Gudapati, H, Neuberger, T, Koduru, S, Ravnic, DJ & Ozbolat, IT 2019, 'Porous tissue strands: Avascular building blocks for scalable tissue fabrication', Biofabrication, vol. 11, no. 1, 015009. https://doi.org/10.1088/1758-5090/aaec22
Heo, DN, Hospodiuk, M & Ozbolat, IT 2019, 'Synergistic interplay between human MSCs and HUVECs in 3D spheroids laden in collagen/fibrin hydrogels for bone tissue engineering', Acta Biomaterialia, vol. 95, pp. 348-356. https://doi.org/10.1016/j.actbio.2019.02.046
Moncal, KK, Ozbolat, V, Datta, P, Heo, DN & Ozbolat, IT 2019, 'Thermally-controlled extrusion-based bioprinting of collagen', Journal of Materials Science: Materials in Medicine, vol. 30, no. 5, 55. https://doi.org/10.1007/s10856-019-6258-2
Dhawan, A, Kennedy, PM, Rizk, EB & Ozbolat, IT 2019, 'Three-dimensional bioprinting for bone and cartilage restoration in orthopaedic surgery', Journal of the American Academy of Orthopaedic Surgeons, vol. 27, no. 5, pp. E215-E226. https://doi.org/10.5435/JAAOS-D-17-00632

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)