Researcher Profile

Researcher Profile

Ibrahim Tarik Ozbolat, PhD

Ibrahim Tarik Ozbolat, PhD

Professor, Engineering Science and Mechanics
Professor, Department of Neurosurgery
Center for Neural Engineering
Scientific Program:Mechanisms of Carcinogenesis
ito1@psu.edu

Research Interests

  • Bioprinting
  • Tissue Engineering
  • Bone and Bones
  • Stem Cells
  • Technology
  • Cartilage
  • Printing
  • Tissue Scaffolds
  • Alginates
  • Biocompatible Materials
  • Biopharmaceutics
  • Articular Cartilage

Recent Publications

2022

Shyam Mohan, T, Datta, P, Nesaei, S, Ozbolat, V & Ozbolat, IT 2022, '3D coaxial bioprinting: Process mechanisms, bioinks and applications', Progress in Biomedical Engineering, vol. 4, no. 2, 022003. https://doi.org/10.1088/2516-1091/ac631c
Kim, MH, Banerjee, D, Celik, N & Ozbolat, IT 2022, 'Aspiration-assisted freeform bioprinting of mesenchymal stem cell spheroids within alginate microgels', Biofabrication, vol. 14, no. 2, 024103. https://doi.org/10.1088/1758-5090/ac4dd8
Moncal, KK, Tigli Aydın, RS, Godzik, KP, Acri, TM, Heo, DN, Rizk, E, Wee, H, Lewis, GS, Salem, AK & Ozbolat, IT 2022, 'Controlled Co-delivery of pPDGF-B and pBMP-2 from intraoperatively bioprinted bone constructs improves the repair of calvarial defects in rats', Biomaterials, vol. 281, 121333. https://doi.org/10.1016/j.biomaterials.2021.121333
Hospodiuk-Karwowski, M, Bokhari, SMQ, Chi, K, Moncal, KK, Ozbolat, V, Ozbolat, IT & Catchmark, JM 2022, 'Dual-charge bacterial cellulose as a potential 3D printable material for soft tissue engineering', Composites Part B: Engineering, vol. 231, 109598. https://doi.org/10.1016/j.compositesb.2021.109598

2021

Kabir, A, Datta, P, Oh, J, Williams, A, Ozbolat, V, Unutmaz, D & Ozbolat, IT 2021, '3D Bioprinting for fabrication of tissue models of COVID-19 infection', Essays in biochemistry, vol. 65, no. 3, pp. 503-518. https://doi.org/10.1042/EBC20200129
Datta, P, Wu, Y, Yu, Y, Moncal, KK & Ozbolat, IT 2021, A Scaffold Free 3D Bioprinted Cartilage Model for In Vitro Toxicology. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2147, Humana Press Inc., pp. 175-183. https://doi.org/10.1007/978-1-0716-0611-7_15
Heo, DN, Ayan, B, Dey, M, Banerjee, D, Wee, H, Lewis, GS & Ozbolat, IT 2021, 'Aspiration-assisted bioprinting of co-cultured osteogenic spheroids for bone tissue engineering', Biofabrication, vol. 13, no. 1, 015013. https://doi.org/10.1088/1758-5090/abc1bf
Zhou, K, Dey, M, Ayan, B, Zhang, Z, Ozbolat, V, Kim, MH, Khristov, V & Ozbolat, IT 2021, 'Fabrication of PDMS microfluidic devices using nanoclay-reinforced Pluronic F-127 as a sacrificial ink', Biomedical Materials (Bristol), vol. 16, no. 4, 045005. https://doi.org/10.1088/1748-605X/abe55e
Moncal, KK, Gudapati, H, Godzik, KP, Heo, DN, Kang, Y, Rizk, E, Ravnic, DJ, Wee, H, Pepley, DF, Ozbolat, V, Lewis, GS, Moore, JZ, Driskell, RR, Samson, TD & Ozbolat, IT 2021, 'Intra-Operative Bioprinting of Hard, Soft, and Hard/Soft Composite Tissues for Craniomaxillofacial Reconstruction', Advanced Functional Materials, vol. 31, no. 29, 2010858. https://doi.org/10.1002/adfm.202010858
Celik, N, Kim, MH, Hayes, DJ & Ozbolat, IT 2021, 'MiRNA induced co-differentiation and cross-talk of adipose tissue-derived progenitor cells for 3D heterotypic pre-vascularized bone formation', Biofabrication, vol. 13, no. 4, 044107. https://doi.org/10.1088/1758-5090/ac23ae
Koduru, SV, Leberfinger, AN, Ozbolat, IT & Ravnic, DJ 2021, 'Navigating the Genomic Landscape of Human Adipose Stem Cell-Derived β-Cells', Stem Cells and Development, vol. 30, no. 23, pp. 1153-1170. https://doi.org/10.1089/scd.2021.0160
Agarwal, T, Banerjee, D, Konwarh, R, Esworthy, T, Kumari, J, Onesto, V, Das, P, Lee, BH, Wagener, FADTG, Makvandi, P, Mattoli, V, Ghosh, SK, Maiti, TK, Zhang, LG & Ozbolat, IT 2021, 'Recent advances in bioprinting technologies for engineering hepatic tissue', Materials Science and Engineering C, vol. 123, 112013. https://doi.org/10.1016/j.msec.2021.112013
Dey, M, Ayan, B, Yurieva, M, Unutmaz, D & Ozbolat, IT 2021, 'Studying Tumor Angiogenesis and Cancer Invasion in a Three-Dimensional Vascularized Breast Cancer Micro-Environment', Advanced Biology, vol. 5, no. 7, 2100090. https://doi.org/10.1002/adbi.202100090

2020

Heo, DN, Alioglu, MA, Wu, Y, Ozbolat, V, Ayan, B, Dey, M, Kang, Y & Ozbolat, IT 2020, '3D Bioprinting of Carbohydrazide-Modified Gelatin into Microparticle-Suspended Oxidized Alginate for the Fabrication of Complex-Shaped Tissue Constructs', ACS Applied Materials and Interfaces, vol. 12, no. 18, pp. 20295-20306. https://doi.org/10.1021/acsami.0c05096
Kang, Y, Datta, P, Shanmughapriya, S & Ozbolat, IT 2020, '3D Bioprinting of Tumor Models for Cancer Research', ACS Applied Bio Materials, vol. 3, no. 9, pp. 5552-5573. https://doi.org/10.1021/acsabm.0c00791
Wu, Y, Zhang, Y, Yu, Y & Ozbolat, IT 2020, 3D Coaxial Bioprinting of Vasculature. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2140, Humana Press Inc., pp. 171-181. https://doi.org/10.1007/978-1-0716-0520-2_11
Datta, P, Dey, M, Ataie, Z, Unutmaz, D & Ozbolat, IT 2020, '3D bioprinting for reconstituting the cancer microenvironment', npj Precision Oncology, vol. 4, no. 1, 18. https://doi.org/10.1038/s41698-020-0121-2
Dey, M & Ozbolat, IT 2020, '3D bioprinting of cells, tissues and organs', Scientific reports, vol. 10, no. 1, 14023. https://doi.org/10.1038/s41598-020-70086-y
Ayan, B, Heo, DN, Zhang, Z, Dey, M, Povilianskas, A, Drapaca, C & Ozbolat, IT 2020, 'Aspiration-assisted bioprinting for precise positioning of biologics', Science Advances, vol. 6, no. 10, eaaw5111. https://doi.org/10.1126/sciadv.aaw5111
Ayan, B, Wu, Y, Karuppagounder, V, Kamal, F & Ozbolat, IT 2020, 'Aspiration-assisted bioprinting of the osteochondral interface', Scientific reports, vol. 10, no. 1, 13148. https://doi.org/10.1038/s41598-020-69960-6
Ayan, B, Celik, N, Zhang, Z, Zhou, K, Kim, MH, Banerjee, D, Wu, Y, Costanzo, F & Ozbolat, IT 2020, 'Aspiration-assisted freeform bioprinting of pre-fabricated tissue spheroids in a yield-stress gel', Communications Physics, vol. 3, no. 1, 183. https://doi.org/10.1038/s42005-020-00449-4
Wu, Y, Ayan, B, Moncal, KK, Kang, Y, Dhawan, A, Koduru, SV, Ravnic, DJ, Kamal, F & Ozbolat, IT 2020, 'Hybrid Bioprinting of Zonally Stratified Human Articular Cartilage Using Scaffold-Free Tissue Strands as Building Blocks', Advanced Healthcare Materials, vol. 9, no. 22, 2001657. https://doi.org/10.1002/adhm.202001657
Wu, Y, Ravnic, DJ & Ozbolat, IT 2020, 'Intraoperative Bioprinting: Repairing Tissues and Organs in a Surgical Setting', Trends in Biotechnology, vol. 38, no. 6, pp. 594-605. https://doi.org/10.1016/j.tibtech.2020.01.004
Gudapati, H, Parisi, D, Colby, RH & Ozbolat, IT 2020, 'Rheological investigation of collagen, fibrinogen, and thrombin solutions for drop-on-demand 3D bioprinting', Soft matter, vol. 16, no. 46, pp. 10506-10517. https://doi.org/10.1039/d0sm01455a
Gudapati, H & Ozbolat, IT 2020, 'The Role of Concentration on Drop Formation and Breakup of Collagen, Fibrinogen, and Thrombin Solutions during Inkjet Bioprinting', Langmuir, vol. 36, no. 50, pp. 15373-15385. https://doi.org/10.1021/acs.langmuir.0c02926
Sun, W, Starly, B, Daly, AC, Burdick, JA, Groll, J, Skeldon, G, Shu, W, Sakai, Y, Shinohara, M, Nishikawa, M, Jang, J, Cho, DW, Nie, M, Takeuchi, S, Ostrovidov, S, Khademhosseini, A, Kamm, RD, Mironov, V, Moroni, L & Ozbolat, IT 2020, 'The bioprinting roadmap', Biofabrication, vol. 12, no. 2, 022002. https://doi.org/10.1088/1758-5090/ab5158

2019

Ulag, S, Kalkandelen, C, Oktar, FN, Uzun, M, Sahin, YM, Karademir, B, Arslan, S, Ozbolat, IT, Mahirogullari, M & Gunduz, O 2019, '3D Printing Artificial Blood Vessel Constructs Using PCL/Chitosan/Hydrogel Biocomposites', ChemistrySelect, vol. 4, no. 8, pp. 2387-2391. https://doi.org/10.1002/slct.201803740
Dodda, A, Wali, A, Wu, Y, Pannone, A, Reddy, LK, Raha, A, Ozdemir, SK, Ozbolat, IT & Das, S 2019, 'Biological One-Way Functions for Secure Key Generation', Advanced Theory and Simulations, vol. 2, no. 2, 1800154. https://doi.org/10.1002/adts.201800154
Wali, A, Dodda, A, Wu, Y, Pannone, A, Reddy Usthili, LK, Ozdemir, SK, Ozbolat, IT & Das, S 2019, 'Biological physically unclonable function', Communications Physics, vol. 2, no. 1, 39. https://doi.org/10.1038/s42005-019-0139-3
Leberfinger, AN, Dinda, S, Wu, Y, Koduru, SV, Ozbolat, V, Ravnic, DJ & Ozbolat, IT 2019, 'Bioprinting functional tissues', Acta Biomaterialia, vol. 95, pp. 32-49. https://doi.org/10.1016/j.actbio.2019.01.009
Koduru, SV, Leberfinger, AN, Pasic, D, Forghani, A, Lince, S, Hayes, DJ, Ozbolat, IT & Ravnic, DJ 2019, 'Cellular Based Strategies for Microvascular Engineering', Stem Cell Reviews and Reports, vol. 15, no. 2, pp. 218-240. https://doi.org/10.1007/s12015-019-09877-4
Moncal, KK, Aydin, RST, Abu-Laban, M, Heo, DN, Rizk, E, Tucker, SM, Lewis, GS, Hayes, D & Ozbolat, IT 2019, 'Collagen-infilled 3D printed scaffolds loaded with miR-148b-transfected bone marrow stem cells improve calvarial bone regeneration in rats', Materials Science and Engineering C, vol. 105, 110128. https://doi.org/10.1016/j.msec.2019.110128
Ozbolat, V, Dey, M, Ayan, B & Ozbolat, IT 2019, 'Extrusion-based printing of sacrificial Carbopol ink for fabrication of microfluidic devices', Biofabrication, vol. 11, no. 3, 034101. https://doi.org/10.1088/1758-5090/ab10ae
Wu, Y, Hospodiuk, M, Peng, W, Gudapati, H, Neuberger, T, Koduru, S, Ravnic, DJ & Ozbolat, IT 2019, 'Porous tissue strands: Avascular building blocks for scalable tissue fabrication', Biofabrication, vol. 11, no. 1, 015009. https://doi.org/10.1088/1758-5090/aaec22
Heo, DN, Hospodiuk, M & Ozbolat, IT 2019, 'Synergistic interplay between human MSCs and HUVECs in 3D spheroids laden in collagen/fibrin hydrogels for bone tissue engineering', Acta Biomaterialia, vol. 95, pp. 348-356. https://doi.org/10.1016/j.actbio.2019.02.046
Moncal, KK, Ozbolat, V, Datta, P, Heo, DN & Ozbolat, IT 2019, 'Thermally-controlled extrusion-based bioprinting of collagen', Journal of Materials Science: Materials in Medicine, vol. 30, no. 5, 55. https://doi.org/10.1007/s10856-019-6258-2
Dhawan, A, Kennedy, PM, Rizk, EB & Ozbolat, IT 2019, 'Three-dimensional bioprinting for bone and cartilage restoration in orthopaedic surgery', Journal of the American Academy of Orthopaedic Surgeons, vol. 27, no. 5, pp. E215-E226. https://doi.org/10.5435/JAAOS-D-17-00632

2018

Ozbolat, V, Dey, M, Ayan, B, Povilianskas, A, Demirel, MC & Ozbolat, IT 2018, '3D Printing of PDMS Improves Its Mechanical and Cell Adhesion Properties', ACS Biomaterials Science and Engineering, vol. 4, no. 2, pp. 682-693. https://doi.org/10.1021/acsbiomaterials.7b00646
Moncal, KK, Heo, DN, Godzik, KP, Sosnoski, DM, Mrowczynski, OD, Rizk, E, Ozbolat, V, Tucker, SM, Gerhard, EM, Dey, M, Lewis, GS, Yang, J & Ozbolat, IT 2018, '3D printing of poly(ϵ-caprolactone)/poly(D,L-lactide-co-glycolide)/hydroxyapatite composite constructs for bone tissue engineering', Journal of Materials Research, vol. 33, no. 14, pp. 1972-1986. https://doi.org/10.1557/jmr.2018.111
Peng, W, Datta, P, Wu, Y, Dey, M, Ayan, B, Dababneh, A & Ozbolat, IT 2018, Challenges in bio-fabrication of organoid cultures. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1107, Springer New York LLC, pp. 53-71. https://doi.org/10.1007/5584_2018_216
Satpathy, A, Datta, P, Wu, Y, Ayan, B, Bayram, E & Ozbolat, IT 2018, 'Developments with 3D bioprinting for novel drug discovery', Expert Opinion on Drug Discovery, vol. 13, no. 12, pp. 1115-1129. https://doi.org/10.1080/17460441.2018.1542427
Datta, P, Barui, A, Wu, Y, Ozbolat, V, Moncal, KK & Ozbolat, IT 2018, 'Essential steps in bioprinting: From pre- to post-bioprinting', Biotechnology Advances, vol. 36, no. 5, pp. 1481-1504. https://doi.org/10.1016/j.biotechadv.2018.06.003
Vural, M, Pena-Francesch, A, Bars-Pomes, J, Jung, H, Gudapati, H, Hatter, CB, Allen, BD, Anasori, B, Ozbolat, IT, Gogotsi, Y & Demirel, MC 2018, 'Inkjet Printing of Self-Assembled 2D Titanium Carbide and Protein Electrodes for Stimuli-Responsive Electromagnetic Shielding', Advanced Functional Materials, vol. 28, no. 32, 1801972. https://doi.org/10.1002/adfm.201801972
Hospodiuk, M, Dey, M, Ayan, B, Sosnoski, D, Moncal, KK, Wu, Y & Ozbolat, IT 2018, 'Sprouting angiogenesis in engineered pseudo islets', Biofabrication, vol. 10, no. 3, 035003. https://doi.org/10.1088/1758-5090/aab002
Leberfinger, AN, Hospodiuk, M, Pena-Francesch, A, Ayan, B, Ozbolat, V, Koduru, SV, Ozbolat, IT, Demirel, MC & Ravnic, DJ 2018, 'Squid ring teeth-coated mesh improves abdominal wall repair', Plastic and Reconstructive Surgery - Global Open, vol. 6, no. 8, e1881. https://doi.org/10.1097/GOX.0000000000001881
Wu, Y, Kennedy, P, Bonazza, N, Yu, Y, Dhawan, A & Ozbolat, I 2021, 'Three-Dimensional Bioprinting of Articular Cartilage: A Systematic Review', Cartilage, vol. 12, no. 1, pp. 76-92. https://doi.org/10.1177/1947603518809410

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)