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Ibrahim Tarik Ozbolat, PhD

Ibrahim Tarik Ozbolat, PhD

Professor, Engineering Science and Mechanics
Professor, Department of Neurosurgery
Center for Neural Engineering
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Bioprinting
  • Tissue Engineering
  • Bone and Bones
  • Technology
  • Stem Cells
  • Blood Vessels
  • Printing
  • Alginates
  • Cartilage
  • Collagen
  • Biocompatible Materials
  • Tissue Scaffolds

Recent Publications


Xie, R, Pal, V, Yu, Y, Lu, X, Gao, M, Liang, S, Huang, M, Peng, W & Ozbolat, IT 2024, 'A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications', Biomaterials, vol. 304, 122408.
Wu, Y, Yang, X, Gupta, D, Alioglu, MA, Qin, M, Ozbolat, V, Li, Y & Ozbolat, IT 2024, 'Dissecting the Interplay Mechanism among Process Parameters toward the Biofabrication of High-Quality Shapes in Embedded Bioprinting', Advanced Functional Materials.
Kang, Y, Yeo, M, Derman, ID, Ravnic, DJ, Singh, YP, Alioglu, MA, Wu, Y, Makkar, J, Driskell, RR & Ozbolat, IT 2024, 'Intraoperative bioprinting of human adipose-derived stem cells and extra-cellular matrix induces hair follicle-like downgrowths and adipose tissue formation during full-thickness craniomaxillofacial skin reconstruction', Bioactive Materials, vol. 33, pp. 114-128.
Yeo, M, Sarkar, A, Singh, YP, Derman, ID, Datta, P & Ozbolat, IT 2024, 'Synergistic coupling between 3D bioprinting and vascularization strategies', Biofabrication, vol. 1, no. 12003, 012003.


Alioglu, MA, Singh, YP, Nagamine, M, Rizvi, SHA, Pal, V, Gerhard, EM, Saini, S, Kim, MH & Ozbolat, IT 2023, '3D embedded printing of microfluidic devices using a functional silicone composite support bath', Additive Manufacturing, vol. 70, 103566.
Alioglu, MA, Yilmaz, YO, Gerhard, EM, Pal, V, Gupta, D, Rizvi, SHA & Ozbolat, IT 2024, 'A Versatile Photocrosslinkable Silicone Composite for 3D Printing Applications', Advanced Materials Technologies, vol. 9, no. 3, 2301858.
Asim, S, Tabish, TA, Liaqat, U, Ozbolat, IT & Rizwan, M 2023, 'Advances in Gelatin Bioinks to Optimize Bioprinted Cell Functions', Advanced Healthcare Materials, vol. 12, no. 17, 2203148.
Ozbolat, IT 2023, 'Advancing the field of 3D bioprinting: an interview with Ibrahim T Ozbolat', Journal of 3D Printing in Medicine, vol. 7, no. 3, 3DP012.
Derman, ID, Singh, YP, Saini, S, Nagamine, M, Banerjee, D & Ozbolat, IT 2023, 'Bioengineering and Clinical Translation of Human Lung and its Components', Advanced Biology, vol. 7, no. 4, 2200267.
Banerjee, D, Ivanova, MM, Celik, N, Kim, MH, Derman, ID, Limgala, RP, Ozbolat, IT & Goker-Alpan, O 2023, 'Biofabrication of an in-vitro bone model for Gaucher disease', Biofabrication, vol. 15, no. 4, 045023.
Moncal, KK, Yeo, M, Celik, N, Acri, TM, Rizk, E, Wee, H, Lewis, GS, Salem, AK & Ozbolat, IT 2023, 'Comparison of in-situ versus ex-situ delivery of polyethylenimine-BMP-2 polyplexes for rat calvarial defect repair via intraoperative bioprinting', Biofabrication, vol. 15, no. 1, 015011.
Gupta, D, Chichkov, B, Vereb, ZJ & Ozbolat, IT 2023, 'Editorial: Innovative 3D technologies in cancer immunity research and therapy', Frontiers in immunology, vol. 14, 1235483.
Tuftee, C, Alsberg, E, Ozbolat, IT & Rizwan, M 2024, 'Emerging granular hydrogel bioinks to improve biological function in bioprinted constructs', Trends in Biotechnology, vol. 42, no. 3, pp. 339-352.
Deniz Derman, I, Yeo, M, Castaneda, DC, Callender, M, Horvath, M, Mo, Z, Xiong, R, Fleming, E, Chen, P, Peeples, ME, Palucka, K, Oh, J & Ozbolat, IT 2023, 'High-throughput bioprinting of the nasal epithelium using patient-derived nasal epithelial cells', Biofabrication, vol. 15, no. 4, 044103.
Pal, V, Singh, YP, Gupta, D, Alioglu, MA, Nagamine, M, Kim, MH & Ozbolat, IT 2023, 'High-throughput microgel biofabrication via air-assisted co-axial jetting for cell encapsulation, 3D bioprinting, and scaffolding applications', Biofabrication, vol. 15, no. 3, 035001.
Alioglu, MA, Yilmaz, YO, Singh, YP, Nagamine, M, Celik, N, Kim, MH, Pal, V, Gupta, D & Ozbolat, IT 2023, 'Nested Biofabrication: Matryoshka-Inspired Intra-Embedded Bioprinting', Small Methods.


Wu, Y, Fuh, J & Ozbolat, IT 2022, 3D Bioprinting in Tissue and Organ Regeneration. Elsevier.
Shyam Mohan, T, Datta, P, Nesaei, S, Ozbolat, V & Ozbolat, IT 2022, '3D coaxial bioprinting: Process mechanisms, bioinks and applications', Progress in Biomedical Engineering, vol. 4, no. 2, 022003.
Kim, MH, Banerjee, D, Celik, N & Ozbolat, IT 2022, 'Aspiration-assisted freeform bioprinting of mesenchymal stem cell spheroids within alginate microgels', Biofabrication, vol. 14, no. 2, 024103.
Dey, M, Kim, MH, Nagamine, M, Karhan, E, Kozhaya, L, Dogan, M, Unutmaz, D & Ozbolat, IT 2022, 'Biofabrication of 3D breast cancer models for dissecting the cytotoxic response of human T cells expressing engineered MAIT cell receptors', Biofabrication, vol. 14, no. 4, 044105.
Dey, M, Kim, MH, Dogan, M, Nagamine, M, Kozhaya, L, Celik, N, Unutmaz, D & Ozbolat, IT 2022, 'Chemotherapeutics and CAR-T Cell-Based Immunotherapeutics Screening on a 3D Bioprinted Vascularized Breast Tumor Model', Advanced Functional Materials, vol. 32, no. 52, 2203966.
Moncal, KK, Tigli Aydın, RS, Godzik, KP, Acri, TM, Heo, DN, Rizk, E, Wee, H, Lewis, GS, Salem, AK & Ozbolat, IT 2022, 'Controlled Co-delivery of pPDGF-B and pBMP-2 from intraoperatively bioprinted bone constructs improves the repair of calvarial defects in rats', Biomaterials, vol. 281, 121333.
Hospodiuk-Karwowski, M, Bokhari, SMQ, Chi, K, Moncal, KK, Ozbolat, V, Ozbolat, IT & Catchmark, JM 2022, 'Dual-charge bacterial cellulose as a potential 3D printable material for soft tissue engineering', Composites Part B: Engineering, vol. 231, 109598.
Datta, P, Cabrera, LY & Ozbolat, IT 2023, 'Ethical challenges with 3D bioprinted tissues and organs', Trends in Biotechnology, vol. 41, no. 1, pp. 6-9.
McLaughlin, C, Datta, P, Singh, YP, Lo, A, Horchler, S, Elcheva, IA, Ozbolat, IT, Ravnic, DJ & Koduru, SV 2022, 'Mesenchymal Stem Cell-Derived Extracellular Vesicles for Therapeutic Use and in Bioengineering Applications', Cells, no. 21, 3366.
Banerjee, D, Singh, YP, Datta, P, Ozbolat, V, O'Donnell, A, Yeo, M & Ozbolat, IT 2022, 'Strategies for 3D bioprinting of spheroids: A comprehensive review', Biomaterials, vol. 291, 121881.
Celik, N, Kim, MH, Yeo, M, Kamal, F, Hayes, DJ & Ozbolat, IT 2022, 'miRNA induced 3D bioprinted-heterotypic osteochondral interface', Biofabrication, vol. 14, no. 4, 044104.


Kabir, A, Datta, P, Oh, J, Williams, A, Ozbolat, V, Unutmaz, D & Ozbolat, IT 2021, '3D Bioprinting for fabrication of tissue models of COVID-19 infection', Essays in biochemistry, vol. 65, no. 3, pp. 503-518.
Datta, P, Wu, Y, Yu, Y, Moncal, KK & Ozbolat, IT 2021, A Scaffold Free 3D Bioprinted Cartilage Model for In Vitro Toxicology. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2147, Humana Press Inc., pp. 175-183.
Heo, DN, Ayan, B, Dey, M, Banerjee, D, Wee, H, Lewis, GS & Ozbolat, IT 2021, 'Aspiration-assisted bioprinting of co-cultured osteogenic spheroids for bone tissue engineering', Biofabrication, vol. 13, no. 1, 015013.
Zhou, K, Dey, M, Ayan, B, Zhang, Z, Ozbolat, V, Kim, MH, Khristov, V & Ozbolat, IT 2021, 'Fabrication of PDMS microfluidic devices using nanoclay-reinforced Pluronic F-127 as a sacrificial ink', Biomedical Materials (Bristol), vol. 16, no. 4, 045005.
Moncal, KK, Gudapati, H, Godzik, KP, Heo, DN, Kang, Y, Rizk, E, Ravnic, DJ, Wee, H, Pepley, DF, Ozbolat, V, Lewis, GS, Moore, JZ, Driskell, RR, Samson, TD & Ozbolat, IT 2021, 'Intra-Operative Bioprinting of Hard, Soft, and Hard/Soft Composite Tissues for Craniomaxillofacial Reconstruction', Advanced Functional Materials, vol. 31, no. 29, 2010858.
Celik, N, Kim, MH, Hayes, DJ & Ozbolat, IT 2021, 'MiRNA induced co-differentiation and cross-talk of adipose tissue-derived progenitor cells for 3D heterotypic pre-vascularized bone formation', Biofabrication, vol. 13, no. 4, 044107.
Khoeini, R, Nosrati, H, Akbarzadeh, A, Eftekhari, A, Kavetskyy, T, Khalilov, R, Ahmadian, E, Nasibova, A, Datta, P, Roshangar, L, Deluca, DC, Davaran, S, Cucchiarini, M & Ozbolat, IT 2021, 'Natural and Synthetic Bioinks for 3D Bioprinting', Advanced NanoBiomed Research, vol. 1, no. 8, 2000097.
Koduru, SV, Leberfinger, AN, Ozbolat, IT & Ravnic, DJ 2021, 'Navigating the Genomic Landscape of Human Adipose Stem Cell-Derived β-Cells', Stem Cells and Development, vol. 30, no. 23, pp. 1153-1170.
Landay, A, Bartley, JM, Banerjee, D, Hargis, G, Haynes, L, Keshavarzian, A, Kuo, CL, Kwon, OS, Li, S, Li, S, Oh, J, Ozbolat, IT, Ucar, D, Xu, M, Yao, X, Unutmaz, D & Kuchel, GA 2021, 'Network Topology of Biological Aging and Geroscience-Guided Approaches to COVID-19', Frontiers in Aging, vol. 2, 695218.
Agarwal, T, Banerjee, D, Konwarh, R, Esworthy, T, Kumari, J, Onesto, V, Das, P, Lee, BH, Wagener, FADTG, Makvandi, P, Mattoli, V, Ghosh, SK, Maiti, TK, Zhang, LG & Ozbolat, IT 2021, 'Recent advances in bioprinting technologies for engineering hepatic tissue', Materials Science and Engineering C, vol. 123, 112013.
Dey, M, Ayan, B, Yurieva, M, Unutmaz, D & Ozbolat, IT 2021, 'Studying Tumor Angiogenesis and Cancer Invasion in a Three-Dimensional Vascularized Breast Cancer Micro-Environment', Advanced Biology, vol. 5, no. 7, 2100090.


Heo, DN, Alioglu, MA, Wu, Y, Ozbolat, V, Ayan, B, Dey, M, Kang, Y & Ozbolat, IT 2020, '3D Bioprinting of Carbohydrazide-Modified Gelatin into Microparticle-Suspended Oxidized Alginate for the Fabrication of Complex-Shaped Tissue Constructs', ACS Applied Materials and Interfaces, vol. 12, no. 18, pp. 20295-20306.
Kang, Y, Datta, P, Shanmughapriya, S & Ozbolat, IT 2020, '3D Bioprinting of Tumor Models for Cancer Research', ACS Applied Bio Materials, vol. 3, no. 9, pp. 5552-5573.
Wu, Y, Zhang, Y, Yu, Y & Ozbolat, IT 2020, 3D Coaxial Bioprinting of Vasculature. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 2140, Humana Press Inc., pp. 171-181.
Datta, P, Dey, M, Ataie, Z, Unutmaz, D & Ozbolat, IT 2020, '3D bioprinting for reconstituting the cancer microenvironment', npj Precision Oncology, vol. 4, no. 1, 18.
Dey, M & Ozbolat, IT 2020, '3D bioprinting of cells, tissues and organs', Scientific reports, vol. 10, no. 1, 14023.
Ayan, B, Heo, DN, Zhang, Z, Dey, M, Povilianskas, A, Drapaca, C & Ozbolat, IT 2020, 'Aspiration-assisted bioprinting for precise positioning of biologics', Science Advances, vol. 6, no. 10, eaaw5111.
Ayan, B, Wu, Y, Karuppagounder, V, Kamal, F & Ozbolat, IT 2020, 'Aspiration-assisted bioprinting of the osteochondral interface', Scientific reports, vol. 10, no. 1, 13148.
Ayan, B, Celik, N, Zhang, Z, Zhou, K, Kim, MH, Banerjee, D, Wu, Y, Costanzo, F & Ozbolat, IT 2020, 'Aspiration-assisted freeform bioprinting of pre-fabricated tissue spheroids in a yield-stress gel', Communications Physics, vol. 3, no. 1, 183.
Wu, Y, Ayan, B, Moncal, KK, Kang, Y, Dhawan, A, Koduru, SV, Ravnic, DJ, Kamal, F & Ozbolat, IT 2020, 'Hybrid Bioprinting of Zonally Stratified Human Articular Cartilage Using Scaffold-Free Tissue Strands as Building Blocks', Advanced Healthcare Materials, vol. 9, no. 22, 2001657.
Wu, Y, Ravnic, DJ & Ozbolat, IT 2020, 'Intraoperative Bioprinting: Repairing Tissues and Organs in a Surgical Setting', Trends in Biotechnology, vol. 38, no. 6, pp. 594-605.
Gudapati, H, Parisi, D, Colby, RH & Ozbolat, IT 2020, 'Rheological investigation of collagen, fibrinogen, and thrombin solutions for drop-on-demand 3D bioprinting', Soft matter, vol. 16, no. 46, pp. 10506-10517.
Gudapati, H & Ozbolat, IT 2020, 'The Role of Concentration on Drop Formation and Breakup of Collagen, Fibrinogen, and Thrombin Solutions during Inkjet Bioprinting', Langmuir, vol. 36, no. 50, pp. 15373-15385.
Sun, W, Starly, B, Daly, AC, Burdick, JA, Groll, J, Skeldon, G, Shu, W, Sakai, Y, Shinohara, M, Nishikawa, M, Jang, J, Cho, DW, Nie, M, Takeuchi, S, Ostrovidov, S, Khademhosseini, A, Kamm, RD, Mironov, V, Moroni, L & Ozbolat, IT 2020, 'The bioprinting roadmap', Biofabrication, vol. 12, no. 2, 022002.