Scott H. Medina - Penn State Cancer Institute
Researcher Profile
Scott H. Medina
Associate Professor, Biomedical Engineering
One Health Microbiome Center
One Health Microbiome Center
Scientific Program:Next-Generation Therapies
Recent Publications
2025
Cordeiro Gomes, FD, Ferreira Alves, MC, Alves Júnior, S & Medina, SH 2025, 'Bactericidal Metal-Organic Gallium Frameworks - Synthesis to Application', Molecular Pharmaceutics, vol. 22, no. 2, pp. 638-646. https://doi.org/10.1021/acs.molpharmaceut.4c01253
Singh, H, Biswas, D, Park, JH, Landmesser, ME, Ravnic, DJ & Medina, SH 2025, 'Non-invasive ultrasonic debridement of implant biofilms via hydrogen-sulfide releasing peptide nanoemulsions', Biomaterials, vol. 321, 123337. https://doi.org/10.1016/j.biomaterials.2025.123337
Kim, I & Medina, SH 2025, 'Ultrasonic disruption of circulating amyloid β aggregates via phase-change peptide nanoemulsions', Biomaterials, vol. 318, 123146. https://doi.org/10.1016/j.biomaterials.2025.123146
2024
Singh, H, Lawanprasert, A, Utkarsh, N, Pimcharoen, S, Dewan, A, Rahoi, D, Kirimanjeswara, GS & Medina, SH 2024, 'Decoupling Fluorous Protein Coatings Yield Heat-Stable and Intrinsically Sterile Bioformulations', ACS Applied Materials and Interfaces, vol. 16, no. 30, pp. 38893-38904. https://doi.org/10.1021/acsami.4c03724
Lawanprasert, A, Singh, H, Pimcharoen, S, Vargas, MG, Dewan, A, Kirimanjeswara, GS & Medina, SH 2024, 'Heat stable and intrinsically sterile liquid protein formulations', Nature communications, vol. 15, no. 1, 10897. https://doi.org/10.1038/s41467-024-55304-9
Miller, MA & Medina, S 2024, 'Life at the interface: Engineering bio-nanomaterials through interfacial molecular self-assembly', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 16, no. 3, e1966. https://doi.org/10.1002/wnan.1966
Miller, MA & Medina, S 2024, 'Synthetic Colonic Mucus Enables the Development of Modular Microbiome Organoids', Advanced Functional Materials, vol. 34, no. 38, 2402514. https://doi.org/10.1002/adfm.202402514
Kim, I, Elliott, JC, Lawanprasert, A, Koehle, AM, Wood, GM, Castro, R, Simon, JC & Medina, SH 2025, 'Twinkling Peptide Nanoemulsions Enable Precision Ultrasound Detection of Atherosclerotic Plaques', Advanced Functional Materials, vol. 35, no. 8, 2415609. https://doi.org/10.1002/adfm.202415609
2023
Lawanprasert, A, Sloand, JN, González Vargas, M, Singh, H, Eldor, T, Miller, MA, Pimcharoen, S, Wang, J, Leighow, SM, Pritchard, JR, Dokholyan, NV & Medina, SH 2023, 'Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions', ChemBioChem, vol. 24, no. 13, e202300159. https://doi.org/10.1002/cbic.202300159
Kim, I, Elliott, JC, Lawanprasert, A, Wood, GM, Simon, JC & Medina, SH 2023, 'Real-Time, In Situ Imaging of Macrophages via Phase-Change Peptide Nanoemulsions', Small, vol. 19, no. 46, 2301673. https://doi.org/10.1002/smll.202301673
Guadagno, AH & Medina, SH 2023, 'The manifold role of octapeptide repeats in prion protein assembly', Peptide Science, vol. 115, no. 2, e24303. https://doi.org/10.1002/pep2.24303
2022
Hale, MM & Medina, SH 2022, 'Biomaterials-Enabled Antithrombotics: Recent Advances and Emerging Strategies', Molecular Pharmaceutics, vol. 19, no. 12, pp. 4453-4465. https://doi.org/10.1021/acs.molpharmaceut.2c00626
Lawanprasert, A, Pimcharoen, S, Sumner, SE, Watson, CT, Manning, KB, Kirimanjeswara, GS & Medina, SH 2022, 'Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation', Small, vol. 18, no. 46, 2203751. https://doi.org/10.1002/smll.202203751
Crowley, NA & Medina, SH 2023, 'Targeted and transient opening of the blood brain barrier in discrete neurocircuits and brain regions', Neuropsychopharmacology, vol. 48, no. 1, pp. 253-254. https://doi.org/10.1038/s41386-022-01380-8
Medina, SH 2022, 'Voices in Molecular Pharmaceutics: Meet Dr. Scott Medina, Manipulator of Biomaterial Properties for Precision Therapeutics', Molecular Pharmaceutics, vol. 19, no. 12, pp. 4392. https://doi.org/10.1021/acs.molpharmaceut.2c00894
2021
Simonson, AW, Umstead, TM, Lawanprasert, A, Klein, B, Almarzooqi, S, Halstead, ES & Medina, SH 2021, 'Extracellular matrix-inspired inhalable aerogels for rapid clearance of pulmonary tuberculosis', Biomaterials, vol. 273, 120848. https://doi.org/10.1016/j.biomaterials.2021.120848
Lawanprasert, A, Simonson, AW, Sumner, SE, Nicol, MJ, Pimcharoen, S, Kirimanjeswara, GS & Medina, SH 2022, 'Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation', Biomacromolecules, vol. 23, no. 3, pp. 1158-1168. https://doi.org/10.1021/acs.biomac.1c01447
Sloand, JN, Culp, TE, Wonderling, NM, Gomez, ED & Medina, SH 2021, 'Mechanomorphogenic Films Formed via Interfacial Assembly of Fluorinated Amino Acids', Advanced Functional Materials, vol. 31, no. 40, 2104223. https://doi.org/10.1002/adfm.202104223
Simonson, AW, Mongia, AS, Aronson, MR, Alumasa, JN, Chan, DC, Lawanprasert, A, Howe, MD, Bolotsky, A, Mal, TK, George, C, Ebrahimi, A, Baughn, AD, Proctor, EA, Keiler, KC & Medina, SH 2021, 'Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry', Nature Biomedical Engineering, vol. 5, no. 5, pp. 467-480. https://doi.org/10.1038/s41551-020-00665-x
Aronson, MR, Medina, SH & Mitchell, MJ 2021, 'Peptide functionalized liposomes for receptor targeted cancer therapy', APL Bioengineering, vol. 5, no. 1, 011501. https://doi.org/10.1063/5.0029860
Lawanprasert, A, Chau, A, Sloand, JN, Hannifin, S & Medina, SH 2021, 'Tuning the Interfacial Properties of Fluorous Colloids Toward Ultrasound Programmable Bioactivity', ACS Applied Materials and Interfaces, vol. 13, no. 5, pp. 5989-5998. https://doi.org/10.1021/acsami.0c20352
Sloand, JN, Rokni, E, Watson, CT, Miller, MA, Manning, KB, Simon, JC & Medina, SH 2021, 'Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis', Advanced Healthcare Materials, vol. 10, no. 16, 2100520. https://doi.org/10.1002/adhm.202100520