Scott H. Medina - Penn State Cancer Institute
Researcher Profile
Scott H. Medina
Associate Professor, Biomedical Engineering
Scientific Program:Next-Generation Therapies
Research Interests
- Peptides
- Neoplasms
- Membranes
- Pharmaceutical Preparations
- Hydrogels
- Dendrimers
- Liver Neoplasms
- Hepatocytes
- Nanoparticles
- Thrombosis
- Polysaccharides
- Membrane Proteins
Recent Publications
2024
Miller, MA & Medina, S 2024, 'Synthetic Colonic Mucus Enables the Development of Modular Microbiome Organoids', Advanced Functional Materials. https://doi.org/10.1002/adfm.202402514
2023
Lawanprasert, A, Sloand, JN, González Vargas, M, Singh, H, Eldor, T, Miller, MA, Pimcharoen, S, Wang, J, Leighow, SM, Pritchard, JR, Dokholyan, NV & Medina, SH 2023, 'Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions', ChemBioChem, vol. 24, no. 13, e202300159. https://doi.org/10.1002/cbic.202300159
Kim, I, Elliott, JC, Lawanprasert, A, Wood, GM, Simon, JC & Medina, SH 2023, 'Real-Time, In Situ Imaging of Macrophages via Phase-Change Peptide Nanoemulsions', Small, vol. 19, no. 46, 2301673. https://doi.org/10.1002/smll.202301673
Guadagno, AH & Medina, SH 2023, 'The manifold role of octapeptide repeats in prion protein assembly', Peptide Science, vol. 115, no. 2, e24303. https://doi.org/10.1002/pep2.24303
2022
Hale, MM & Medina, SH 2022, 'Biomaterials-Enabled Antithrombotics: Recent Advances and Emerging Strategies', Molecular Pharmaceutics, vol. 19, no. 12, pp. 4453-4465. https://doi.org/10.1021/acs.molpharmaceut.2c00626
Lawanprasert, A, Pimcharoen, S, Sumner, SE, Watson, CT, Manning, KB, Kirimanjeswara, GS & Medina, SH 2022, 'Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation', Small, vol. 18, no. 46, 2203751. https://doi.org/10.1002/smll.202203751
Crowley, NA & Medina, SH 2023, 'Targeted and transient opening of the blood brain barrier in discrete neurocircuits and brain regions', Neuropsychopharmacology, vol. 48, no. 1, pp. 253-254. https://doi.org/10.1038/s41386-022-01380-8
Medina, SH 2022, 'Voices in Molecular Pharmaceutics: Meet Dr. Scott Medina, Manipulator of Biomaterial Properties for Precision Therapeutics', Molecular Pharmaceutics, vol. 19, no. 12, pp. 4392. https://doi.org/10.1021/acs.molpharmaceut.2c00894
2021
Simonson, AW, Umstead, TM, Lawanprasert, A, Klein, B, Almarzooqi, S, Halstead, ES & Medina, SH 2021, 'Extracellular matrix-inspired inhalable aerogels for rapid clearance of pulmonary tuberculosis', Biomaterials, vol. 273, 120848. https://doi.org/10.1016/j.biomaterials.2021.120848
Lawanprasert, A, Simonson, AW, Sumner, SE, Nicol, MJ, Pimcharoen, S, Kirimanjeswara, GS & Medina, SH 2022, 'Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation', Biomacromolecules, vol. 23, no. 3, pp. 1158-1168. https://doi.org/10.1021/acs.biomac.1c01447
Sloand, JN, Culp, TE, Wonderling, NM, Gomez, ED & Medina, SH 2021, 'Mechanomorphogenic Films Formed via Interfacial Assembly of Fluorinated Amino Acids', Advanced Functional Materials, vol. 31, no. 40, 2104223. https://doi.org/10.1002/adfm.202104223
Simonson, AW, Mongia, AS, Aronson, MR, Alumasa, JN, Chan, DC, Lawanprasert, A, Howe, MD, Bolotsky, A, Mal, TK, George, C, Ebrahimi, A, Baughn, AD, Proctor, EA, Keiler, KC & Medina, SH 2021, 'Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry', Nature Biomedical Engineering, vol. 5, no. 5, pp. 467-480. https://doi.org/10.1038/s41551-020-00665-x
Aronson, MR, Medina, SH & Mitchell, MJ 2021, 'Peptide functionalized liposomes for receptor targeted cancer therapy', APL Bioengineering, vol. 5, no. 1, 011501. https://doi.org/10.1063/5.0029860
Lawanprasert, A, Chau, A, Sloand, JN, Hannifin, S & Medina, SH 2021, 'Tuning the Interfacial Properties of Fluorous Colloids Toward Ultrasound Programmable Bioactivity', ACS Applied Materials and Interfaces, vol. 13, no. 5, pp. 5989-5998. https://doi.org/10.1021/acsami.0c20352
Sloand, JN, Rokni, E, Watson, CT, Miller, MA, Manning, KB, Simon, JC & Medina, SH 2021, 'Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis', Advanced Healthcare Materials, vol. 10, no. 16, 2100520. https://doi.org/10.1002/adhm.202100520
2020
Simonson, AW, Aronson, MR, Medina, SH & Medina, SH 2020, 'Antimicrobial Scaffolds', Molecules, vol. 25, no. 12, 2751. https://doi.org/10.3390/molecules25122751
Lawanprasert, A, Guinan, CA, Langford, EA, Hawkins, CE, Sloand, JN, Fescemyer, HW, Aronson, MR, Halle, JA, Marden, JH & Medina, SH 2020, 'Discovery of antitumor lectins from rainforest tree root transcriptomes', PloS one, vol. 15, no. 2, e0229467. https://doi.org/10.1371/journal.pone.0229467
Sloand, JN, Miller, MA & Medina, SH 2021, 'Fluorinated peptide biomaterials', Peptide Science, vol. 113, no. 2, e24184. https://doi.org/10.1002/pep2.24184
Tu, YM, Song, W, Ren, T, Shen, YX, Chowdhury, R, Rajapaksha, P, Culp, TE, Samineni, L, Lang, C, Thokkadam, A, Carson, D, Dai, Y, Mukthar, A, Zhang, M, Parshin, A, Sloand, JN, Medina, SH, Grzelakowski, M, Bhattacharya, D, Phillip, WA, Gomez, ED, Hickey, RJ, Wei, Y & Kumar, M 2020, 'Rapid fabrication of precise high-throughput filters from membrane protein nanosheets', Nature Materials, vol. 19, no. 3, pp. 347-354. https://doi.org/10.1038/s41563-019-0577-z
Aronson, MR, Dahl, ES, Halle, JA, Simonson, AW, Gogal, RA, Glick, AB, Aird, KM & Medina, SH 2020, 'Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers', Cellular and Molecular Bioengineering, vol. 13, no. 5, pp. 447-461. https://doi.org/10.1007/s12195-020-00626-z
Sloand, JN, Nguyen, TT, Zinck, SA, Cook, EC, Zimudzi, TJ, Showalter, SA, Glick, AB, Simon, JC & Medina, SH 2020, 'Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks', ACS nano, vol. 14, no. 4, pp. 4061-4073. https://doi.org/10.1021/acsnano.9b08745