Researcher Profile

Researcher Profile

Scott H. Medina

Scott H. Medina

Assistant Professor, Biomedical Engineering
Scientific Program:Next-Generation Therapies
shm126@psu.edu

Research Interests

  • Peptides
  • Neoplasms
  • Liver Neoplasms
  • Hepatocytes
  • Pharmaceutical Preparations
  • Nanoparticles
  • Hydrogels
  • Polysaccharides
  • Dendrimers
  • Membranes
  • Gold
  • Mycobacterium tuberculosis

Recent Publications

2021

Simonson, AW, Umstead, TM, Lawanprasert, A, Klein, B, Almarzooqi, S, Halstead, ES & Medina, SH 2021, 'Extracellular matrix-inspired inhalable aerogels for rapid clearance of pulmonary tuberculosis', Biomaterials, vol. 273, 120848. https://doi.org/10.1016/j.biomaterials.2021.120848
Simonson, AW, Mongia, AS, Aronson, MR, Alumasa, JN, Chan, DC, Lawanprasert, A, Howe, MD, Bolotsky, A, Mal, TK, George, C, Ebrahimi, A, Baughn, AD, Proctor, EA, Keiler, KC & Medina, SH 2021, 'Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry', Nature Biomedical Engineering, vol. 5, no. 5, pp. 467-480. https://doi.org/10.1038/s41551-020-00665-x
Aronson, MR, Medina, SH & Mitchell, MJ 2021, 'Peptide functionalized liposomes for receptor targeted cancer therapy', APL Bioengineering, vol. 5, no. 1, 011501. https://doi.org/10.1063/5.0029860
Lawanprasert, A, Chau, A, Sloand, JN, Hannifin, S & Medina, SH 2021, 'Tuning the Interfacial Properties of Fluorous Colloids Toward Ultrasound Programmable Bioactivity', ACS Applied Materials and Interfaces, vol. 13, no. 5, pp. 5989-5998. https://doi.org/10.1021/acsami.0c20352
Sloand, JN, Rokni, E, Watson, CT, Miller, MA, Manning, KB, Simon, JC & Medina, SH 2021, 'Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis', Advanced Healthcare Materials, vol. 10, no. 16, 2100520. https://doi.org/10.1002/adhm.202100520

2020

Simonson, AW, Aronson, MR, Medina, SH & Medina, SH 2020, 'Antimicrobial Scaffolds', Molecules, vol. 25, no. 12, 2751. https://doi.org/10.3390/molecules25122751
Lawanprasert, A, Guinan, CA, Langford, EA, Hawkins, CE, Sloand, JN, Fescemyer, HW, Aronson, MR, Halle, JA, Marden, JH & Medina, SH 2020, 'Discovery of antitumor lectins from rainforest tree root transcriptomes', PloS one, vol. 15, no. 2, e0229467. https://doi.org/10.1371/journal.pone.0229467
Sloand, JN, Miller, MA & Medina, SH 2021, 'Fluorinated peptide biomaterials', Peptide Science, vol. 113, no. 2, e24184. https://doi.org/10.1002/pep2.24184
Tu, YM, Song, W, Ren, T, Shen, YX, Chowdhury, R, Rajapaksha, P, Culp, TE, Samineni, L, Lang, C, Thokkadam, A, Carson, D, Dai, Y, Mukthar, A, Zhang, M, Parshin, A, Sloand, JN, Medina, SH, Grzelakowski, M, Bhattacharya, D, Phillip, WA, Gomez, ED, Hickey, RJ, Wei, Y & Kumar, M 2020, 'Rapid fabrication of precise high-throughput filters from membrane protein nanosheets', Nature Materials, vol. 19, no. 3, pp. 347-354. https://doi.org/10.1038/s41563-019-0577-z
Aronson, MR, Dahl, ES, Halle, JA, Simonson, AW, Gogal, RA, Glick, AB, Aird, KM & Medina, SH 2020, 'Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers', Cellular and Molecular Bioengineering, vol. 13, no. 5, pp. 447-461. https://doi.org/10.1007/s12195-020-00626-z
Sloand, JN, Nguyen, TT, Zinck, SA, Cook, EC, Zimudzi, TJ, Showalter, SA, Glick, AB, Simon, JC & Medina, SH 2020, 'Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks', ACS nano, vol. 14, no. 4, pp. 4061-4073. https://doi.org/10.1021/acsnano.9b08745

2019

Medina, SH, Bush, B, Cam, M, Sevcik, E, DelRio, FW, Nandy, K & Schneider, JP 2019, 'Identification of a mechanogenetic link between substrate stiffness and chemotherapeutic response in breast cancer', Biomaterials, vol. 202, pp. 1-11. https://doi.org/10.1016/j.biomaterials.2019.02.018

2018

Kapur, A, Wang, W, Diaz Hernandez, J, Medina, S, Schneider, JP & Mattoussi, H 2018, Anti-microbial peptide facilitated cytosolic delivery of metallic gold nanomaterials. in WJ Parak, M Osinski & X-J Liang (eds), Colloidal Nanoparticles for Biomedical Applications XIII., 105070R, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10507, SPIE, Colloidal Nanoparticles for Biomedical Applications XIII 2018, San Francisco, United States, 1/27/18. https://doi.org/10.1117/12.2285661
Simonson, AW, Lawanprasert, A, Goralski, TDP, Keiler, KC & Medina, SH 2019, 'Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 17, pp. 391-400. https://doi.org/10.1016/j.nano.2018.10.008
Kapur, A, Medina, SH, Wang, W, Palui, G, Ji, X, Schneider, JP & Mattoussi, H 2018, 'Enhanced Uptake of Luminescent Quantum Dots by Live Cells Mediated by a Membrane-Active Peptide', ACS Omega, vol. 3, no. 12, pp. 17164-17172. https://doi.org/10.1021/acsomega.8b02918
Kapur, A, Medina, SH, Wang, W, Palui, G, Schneider, JP & Mattoussi, H 2018, 'Intracellular Delivery of Gold Nanocolloids Promoted by a Chemically Conjugated Anticancer Peptide', ACS Omega, vol. 3, no. 10, pp. 12754-12762. https://doi.org/10.1021/acsomega.8b02276
Aronson, MR, Simonson, AW, Orchard, LM, Llinás, M & Medina, SH 2018, 'Lipopeptisomes: Anticancer peptide-assembled particles for fusolytic oncotherapy', Acta Biomaterialia, vol. 80, pp. 269-277. https://doi.org/10.1016/j.actbio.2018.09.025

2017

Medina, SH, Michie, MS, Miller, SE, Schnermann, MJ & Schneider, JP 2017, 'Fluorous Phase-Directed Peptide Assembly Affords Nano-Peptisomes Capable of Ultrasound-Triggered Cellular Delivery', Angewandte Chemie - International Edition, vol. 56, no. 38, pp. 11404-11408. https://doi.org/10.1002/anie.201704649
Kapur, A, Safi, M, Domitrovic, T, Medina, S, Palui, G, Johnson, JE, Schneider, J & Mattoussi, H 2017, Peptide mediated intracellular delivery of semiconductor quantum dots. in M Osinski, WJ Parak & X-J Liang (eds), Colloidal Nanoparticles for Biomedical Applications XII., 100780S, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10078, SPIE, Colloidal Nanoparticles for Biomedical Applications XII 2017, San Francisco, United States, 1/28/17. https://doi.org/10.1117/12.2252717

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)