Researcher Profile

Researcher Profile

Scott H. Medina

Scott H. Medina

Associate Professor, Biomedical Engineering
Scientific Program:Next-Generation Therapies
shm126@psu.edu

Research Interests

  • Peptides
  • Neoplasms
  • Liver Neoplasms
  • Hepatocytes
  • Nanoparticles
  • Hydrogels
  • Thrombosis
  • Polysaccharides
  • Biocompatible Materials
  • Dendrimers
  • Membranes
  • Gold

Recent Publications

2022

Hale, MM & Medina, SH 2022, 'Biomaterials-Enabled Antithrombotics: Recent Advances and Emerging Strategies', Molecular Pharmaceutics, vol. 19, no. 12, pp. 4453-4465. https://doi.org/10.1021/acs.molpharmaceut.2c00626
Lawanprasert, A, Pimcharoen, S, Sumner, SE, Watson, CT, Manning, KB, Kirimanjeswara, GS & Medina, SH 2022, 'Heparin-Peptide Nanogranules for Thrombosis-Actuated Anticoagulation', Small. https://doi.org/10.1002/smll.202203751
Crowley, NA & Medina, SH 2023, 'Targeted and transient opening of the blood brain barrier in discrete neurocircuits and brain regions', Neuropsychopharmacology, vol. 48, no. 1, pp. 253-254. https://doi.org/10.1038/s41386-022-01380-8
Medina, SH 2022, 'Voices in Molecular Pharmaceutics: Meet Dr. Scott Medina, Manipulator of Biomaterial Properties for Precision Therapeutics', Molecular Pharmaceutics, vol. 19, no. 12, pp. 4392. https://doi.org/10.1021/acs.molpharmaceut.2c00894

2021

Simonson, AW, Umstead, TM, Lawanprasert, A, Klein, B, Almarzooqi, S, Halstead, ES & Medina, SH 2021, 'Extracellular matrix-inspired inhalable aerogels for rapid clearance of pulmonary tuberculosis', Biomaterials, vol. 273, 120848. https://doi.org/10.1016/j.biomaterials.2021.120848
Lawanprasert, A, Simonson, AW, Sumner, SE, Nicol, MJ, Pimcharoen, S, Kirimanjeswara, GS & Medina, SH 2022, 'Inhalable SARS-CoV-2 Mimetic Particles Induce Pleiotropic Antigen Presentation', Biomacromolecules, vol. 23, no. 3, pp. 1158-1168. https://doi.org/10.1021/acs.biomac.1c01447
Sloand, JN, Culp, TE, Wonderling, NM, Gomez, ED & Medina, SH 2021, 'Mechanomorphogenic Films Formed via Interfacial Assembly of Fluorinated Amino Acids', Advanced Functional Materials, vol. 31, no. 40, 2104223. https://doi.org/10.1002/adfm.202104223
Simonson, AW, Mongia, AS, Aronson, MR, Alumasa, JN, Chan, DC, Lawanprasert, A, Howe, MD, Bolotsky, A, Mal, TK, George, C, Ebrahimi, A, Baughn, AD, Proctor, EA, Keiler, KC & Medina, SH 2021, 'Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry', Nature Biomedical Engineering, vol. 5, no. 5, pp. 467-480. https://doi.org/10.1038/s41551-020-00665-x
Aronson, MR, Medina, SH & Mitchell, MJ 2021, 'Peptide functionalized liposomes for receptor targeted cancer therapy', APL Bioengineering, vol. 5, no. 1, 011501. https://doi.org/10.1063/5.0029860
Lawanprasert, A, Chau, A, Sloand, JN, Hannifin, S & Medina, SH 2021, 'Tuning the Interfacial Properties of Fluorous Colloids Toward Ultrasound Programmable Bioactivity', ACS Applied Materials and Interfaces, vol. 13, no. 5, pp. 5989-5998. https://doi.org/10.1021/acsami.0c20352
Sloand, JN, Rokni, E, Watson, CT, Miller, MA, Manning, KB, Simon, JC & Medina, SH 2021, 'Ultrasound-Responsive Nanopeptisomes Enable Synchronous Spatial Imaging and Inhibition of Clot Growth in Deep Vein Thrombosis', Advanced Healthcare Materials, vol. 10, no. 16, 2100520. https://doi.org/10.1002/adhm.202100520

2020

Simonson, AW, Aronson, MR, Medina, SH & Medina, SH 2020, 'Antimicrobial Scaffolds', Molecules, vol. 25, no. 12, 2751. https://doi.org/10.3390/molecules25122751
Lawanprasert, A, Guinan, CA, Langford, EA, Hawkins, CE, Sloand, JN, Fescemyer, HW, Aronson, MR, Halle, JA, Marden, JH & Medina, SH 2020, 'Discovery of antitumor lectins from rainforest tree root transcriptomes', PloS one, vol. 15, no. 2, e0229467. https://doi.org/10.1371/journal.pone.0229467
Sloand, JN, Miller, MA & Medina, SH 2021, 'Fluorinated peptide biomaterials', Peptide Science, vol. 113, no. 2, e24184. https://doi.org/10.1002/pep2.24184
Tu, YM, Song, W, Ren, T, Shen, YX, Chowdhury, R, Rajapaksha, P, Culp, TE, Samineni, L, Lang, C, Thokkadam, A, Carson, D, Dai, Y, Mukthar, A, Zhang, M, Parshin, A, Sloand, JN, Medina, SH, Grzelakowski, M, Bhattacharya, D, Phillip, WA, Gomez, ED, Hickey, RJ, Wei, Y & Kumar, M 2020, 'Rapid fabrication of precise high-throughput filters from membrane protein nanosheets', Nature Materials, vol. 19, no. 3, pp. 347-354. https://doi.org/10.1038/s41563-019-0577-z
Aronson, MR, Dahl, ES, Halle, JA, Simonson, AW, Gogal, RA, Glick, AB, Aird, KM & Medina, SH 2020, 'Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers', Cellular and Molecular Bioengineering, vol. 13, no. 5, pp. 447-461. https://doi.org/10.1007/s12195-020-00626-z
Sloand, JN, Nguyen, TT, Zinck, SA, Cook, EC, Zimudzi, TJ, Showalter, SA, Glick, AB, Simon, JC & Medina, SH 2020, 'Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks', ACS nano, vol. 14, no. 4, pp. 4061-4073. https://doi.org/10.1021/acsnano.9b08745

2019

Medina, SH, Bush, B, Cam, M, Sevcik, E, DelRio, FW, Nandy, K & Schneider, JP 2019, 'Identification of a mechanogenetic link between substrate stiffness and chemotherapeutic response in breast cancer', Biomaterials, vol. 202, pp. 1-11. https://doi.org/10.1016/j.biomaterials.2019.02.018

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)