Researcher Profile

Researcher Profile

Yi Qiu, PhD

Yi Qiu, PhD

Associate Professor, Department of Cellular and Molecular Physiology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Genes
  • Chromatin
  • Acetylation
  • Proteins
  • Histones
  • Epigenomics
  • Transcription Factors
  • Gene Expression
  • Acute Myeloid Leukemia
  • Histone Deacetylases
  • Histone Deacetylase 1
  • Neoplasms

Recent Publications


Yan, B, Claxton, D, Huang, S & Qiu, Y 2020, 'AML chemoresistance: The role of mutant TP53 subclonal expansion and therapy strategy', Experimental Hematology, vol. 87, pp. 13-19.
Qiu, Y & Huang, S 2020, 'CTCF-mediated genome organization and leukemogenesis', Leukemia, vol. 34, no. 9, pp. 2295-2304.
Shi, Y, Zhao, H, Ye, J, Li, Z, Deng, M, Zha, J, Zhou, Y, Zeng, H, Lin, Y, Pu, X, Guo, C, Song, H, Qiu, Y & Xu, B 2020, 'Low-dose triptolide enhances antitumor effect of JQ1 on acute myeloid leukemia through inhibiting RNA polymerase II in vitro and in vivo', Molecular Carcinogenesis, vol. 59, no. 9, pp. 1076-1087.
Yan, B, Chen, Q, Xu, J, Li, W, Xu, B & Qiu, Y 2020, 'Low-frequency TP53 hotspot mutation contributes to chemoresistance through clonal expansion in acute myeloid leukemia', Leukemia, vol. 34, no. 7, pp. 1816-1827.
Kim, MY, Yan, B, Huang, S & Qiu, Y 2020, 'Regulating the regulators: The role of histone deacetylase 1 (hdac1) in erythropoiesis', International journal of molecular sciences, vol. 21, no. 22, 8460, pp. 1-22.


Luo, H, Zhu, G, Xu, J, Lai, Q, Yan, B, Guo, Y, Fung, TK, Zeisig, BB, Cui, Y, Zha, J, Cogle, C, Wang, F, Xu, B, Yang, FC, Li, W, So, CWE, Qiu, Y, Xu, M & Huang, S 2019, 'HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice', Cancer Cell, vol. 36, no. 6, pp. 645-659.e8.
Luo, H, Sobh, A, Vulpe, CD, Brewer, E, Dovat, S, Qiu, Y & Huang, S 2019, 'HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries', Journal of visualized experiments : JoVE, no. 145.


Luo, H, Wang, F, Zha, J, Li, H, Yan, B, Du, Q, Yang, F, Sobh, A, Vulpe, C, Drusbosky, L, Cogle, C, Chepelev, I, Xu, B, Nimer, SD, Licht, J, Qiu, Y, Chen, B, Xu, M & Huang, S 2018, 'CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia', Blood, vol. 132, no. 8, pp. 837-848.
Yan, B, Chen, Q, Shimada, K, Tang, M, Li, H, Gurumurthy, A, Khoury, JD, Xu, B, Huang, S & Qiu, Y 2019, 'Histone deacetylase inhibitor targets CD123/CD47-positive cells and reverse chemoresistance phenotype in acute myeloid leukemia', Leukemia, vol. 33, no. 4, pp. 931-944.


Qiu, Y & Huang, S 2017, 'Catching global interactions in vivo', Cell and Bioscience, vol. 7, no. 1, 49.
Jian, W, Yan, B, Huang, S & Qiu, Y 2017, 'Histone deacetylase 1 activates PU.1 gene transcription through regulating TAF9 deacetylation and transcription factor IID assembly', FASEB Journal, vol. 31, no. 9, pp. 4104-4116.
Li, X, Mei, Y, Yan, B, Vitriol, E, Huang, S, Ji, P & Qiu, Y 2017, 'Histone deacetylase 6 regulates cytokinesis and erythrocyte enucleation through deacetylation of formin protein mDia2', Haematologica, vol. 102, no. 6, pp. 984-994.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)