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Yi Qiu, PhD

Yi Qiu, PhD

Associate Professor, Department of Cellular and Molecular Physiology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Genes
  • Chromatin
  • Acetylation
  • Proteins
  • Histones
  • Acute Myeloid Leukemia
  • Gene Expression
  • Epigenomics
  • Transcription Factors
  • Histone Deacetylases
  • Hematopoiesis
  • Neoplasms

Recent Publications


Lai, Q, Hamamoto, K, Luo, H, Zaroogian, Z, Zhou, C, Lesperance, J, Zha, J, Qiu, Y, Guryanova, OA, Huang, S & Xu, B 2023, 'NPM1 mutation reprograms leukemic transcription network via reshaping TAD topology', Leukemia, vol. 37, no. 8, pp. 1732-1736.


Luo, H, Zhu, G, Eshelman, MA, Fung, TK, Lai, Q, Wang, F, Zeisig, BB, Lesperance, J, Ma, X, Chen, S, Cesari, N, Cogle, C, Chen, B, Xu, B, Yang, FC, So, CWE, Qiu, Y, Xu, M & Huang, S 2022, 'HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia', Molecular cell, vol. 82, no. 4, pp. 833-851.e11.


Yan, B, Yang, J, Kim, MY, Luo, H, Cesari, N, Yang, T, Strouboulis, J, Zhang, J, Hardison, R, Huang, S & Qiu, Y 2021, 'HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis', Nucleic acids research, vol. 49, no. 17, pp. 9783-9798.
Zhu, G, Luo, H, Feng, Y, Guryanova, OA, Xu, J, Chen, S, Lai, Q, Sharma, A, Xu, B, Zhao, Z, Feng, R, Ni, H, Claxton, D, Guo, Y, Mesa, RA, Qiu, Y, Yang, FC, Li, W, Nimer, SD, Huang, S & Xu, M 2021, 'HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia', Nature communications, vol. 12, no. 1, 1956.
Qiu, Y, Xu, M & Huang, S 2021, 'Long noncoding RNAs: emerging regulators of normal and malignant hematopoiesis', Blood, vol. 138, no. 23, pp. 2327-2336.


Yan, B, Claxton, D, Huang, S & Qiu, Y 2020, 'AML chemoresistance: The role of mutant TP53 subclonal expansion and therapy strategy', Experimental Hematology, vol. 87, pp. 13-19.
Qiu, Y & Huang, S 2020, 'CTCF-mediated genome organization and leukemogenesis', Leukemia, vol. 34, no. 9, pp. 2295-2304.
Shi, Y, Zhao, H, Ye, J, Li, Z, Deng, M, Zha, J, Zhou, Y, Zeng, H, Lin, Y, Pu, X, Guo, C, Song, H, Qiu, Y & Xu, B 2020, 'Low-dose triptolide enhances antitumor effect of JQ1 on acute myeloid leukemia through inhibiting RNA polymerase II in vitro and in vivo', Molecular Carcinogenesis, vol. 59, no. 9, pp. 1076-1087.
Yan, B, Chen, Q, Xu, J, Li, W, Xu, B & Qiu, Y 2020, 'Low-frequency TP53 hotspot mutation contributes to chemoresistance through clonal expansion in acute myeloid leukemia', Leukemia, vol. 34, no. 7, pp. 1816-1827.
Kim, MY, Yan, B, Huang, S & Qiu, Y 2020, 'Regulating the regulators: The role of histone deacetylase 1 (hdac1) in erythropoiesis', International journal of molecular sciences, vol. 21, no. 22, 8460, pp. 1-22.