Yi Qiu, PhD - Penn State Cancer Institute
Researcher Profile
Yi Qiu, PhD
Associate Professor, Department of Cellular and Molecular Physiology
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Genes
- Chromatin
- Acetylation
- Proteins
- Histones
- Acute Myeloid Leukemia
- Gene Expression
- Epigenomics
- Transcription Factors
- Histone Deacetylases
- Hematopoiesis
- Neoplasms
Recent Publications
2023
Lai, Q, Hamamoto, K, Luo, H, Zaroogian, Z, Zhou, C, Lesperance, J, Zha, J, Qiu, Y, Guryanova, OA, Huang, S & Xu, B 2023, 'NPM1 mutation reprograms leukemic transcription network via reshaping TAD topology', Leukemia, vol. 37, no. 8, pp. 1732-1736. https://doi.org/10.1038/s41375-023-01942-9
2022
Luo, H, Zhu, G, Eshelman, MA, Fung, TK, Lai, Q, Wang, F, Zeisig, BB, Lesperance, J, Ma, X, Chen, S, Cesari, N, Cogle, C, Chen, B, Xu, B, Yang, FC, So, CWE, Qiu, Y, Xu, M & Huang, S 2022, 'HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia', Molecular cell, vol. 82, no. 4, pp. 833-851.e11. https://doi.org/10.1016/j.molcel.2022.01.014
2021
Yan, B, Yang, J, Kim, MY, Luo, H, Cesari, N, Yang, T, Strouboulis, J, Zhang, J, Hardison, R, Huang, S & Qiu, Y 2021, 'HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis', Nucleic acids research, vol. 49, no. 17, pp. 9783-9798. https://doi.org/10.1093/nar/gkab737
Zhu, G, Luo, H, Feng, Y, Guryanova, OA, Xu, J, Chen, S, Lai, Q, Sharma, A, Xu, B, Zhao, Z, Feng, R, Ni, H, Claxton, D, Guo, Y, Mesa, RA, Qiu, Y, Yang, FC, Li, W, Nimer, SD, Huang, S & Xu, M 2021, 'HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia', Nature communications, vol. 12, no. 1, 1956. https://doi.org/10.1038/s41467-021-22095-2
Qiu, Y, Xu, M & Huang, S 2021, 'Long noncoding RNAs: emerging regulators of normal and malignant hematopoiesis', Blood, vol. 138, no. 23, pp. 2327-2336. https://doi.org/10.1182/blood.2021011992
2020
Yan, B, Claxton, D, Huang, S & Qiu, Y 2020, 'AML chemoresistance: The role of mutant TP53 subclonal expansion and therapy strategy', Experimental Hematology, vol. 87, pp. 13-19. https://doi.org/10.1016/j.exphem.2020.06.003
Qiu, Y & Huang, S 2020, 'CTCF-mediated genome organization and leukemogenesis', Leukemia, vol. 34, no. 9, pp. 2295-2304. https://doi.org/10.1038/s41375-020-0906-x
Shi, Y, Zhao, H, Ye, J, Li, Z, Deng, M, Zha, J, Zhou, Y, Zeng, H, Lin, Y, Pu, X, Guo, C, Song, H, Qiu, Y & Xu, B 2020, 'Low-dose triptolide enhances antitumor effect of JQ1 on acute myeloid leukemia through inhibiting RNA polymerase II in vitro and in vivo', Molecular Carcinogenesis, vol. 59, no. 9, pp. 1076-1087. https://doi.org/10.1002/mc.23238
Yan, B, Chen, Q, Xu, J, Li, W, Xu, B & Qiu, Y 2020, 'Low-frequency TP53 hotspot mutation contributes to chemoresistance through clonal expansion in acute myeloid leukemia', Leukemia, vol. 34, no. 7, pp. 1816-1827. https://doi.org/10.1038/s41375-020-0710-7
Kim, MY, Yan, B, Huang, S & Qiu, Y 2020, 'Regulating the regulators: The role of histone deacetylase 1 (hdac1) in erythropoiesis', International journal of molecular sciences, vol. 21, no. 22, 8460, pp. 1-22. https://doi.org/10.3390/ijms21228460