Researcher Profile

Researcher Profile

Yi Qiu, PhD

Yi Qiu, PhD

Associate Professor, Department of Cellular and Molecular Physiology
Scientific Program:Mechanisms of Carcinogenesis
yqq5075@psu.edu

Research Interests

  • Genes
  • Chromatin
  • Acetylation
  • Proteins
  • Histones
  • Epigenomics
  • Gene Expression
  • Acute Myeloid Leukemia
  • Transcription Factors
  • Histone Deacetylases
  • Histone Deacetylase 1
  • Neoplasms

Recent Publications

2021

Zhu, G, Luo, H, Feng, Y, Guryanova, OA, Xu, J, Chen, S, Lai, Q, Sharma, A, Xu, B, Zhao, Z, Feng, R, Ni, H, Claxton, D, Guo, Y, Mesa, RA, Qiu, Y, Yang, FC, Li, W, Nimer, SD, Huang, S & Xu, M 2021, 'HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia', Nature communications, vol. 12, no. 1, 1956. https://doi.org/10.1038/s41467-021-22095-2

2020

Yan, B, Claxton, D, Huang, S & Qiu, Y 2020, 'AML chemoresistance: The role of mutant TP53 subclonal expansion and therapy strategy', Experimental Hematology, vol. 87, pp. 13-19. https://doi.org/10.1016/j.exphem.2020.06.003
Qiu, Y & Huang, S 2020, 'CTCF-mediated genome organization and leukemogenesis', Leukemia, vol. 34, no. 9, pp. 2295-2304. https://doi.org/10.1038/s41375-020-0906-x
Shi, Y, Zhao, H, Ye, J, Li, Z, Deng, M, Zha, J, Zhou, Y, Zeng, H, Lin, Y, Pu, X, Guo, C, Song, H, Qiu, Y & Xu, B 2020, 'Low-dose triptolide enhances antitumor effect of JQ1 on acute myeloid leukemia through inhibiting RNA polymerase II in vitro and in vivo', Molecular Carcinogenesis, vol. 59, no. 9, pp. 1076-1087. https://doi.org/10.1002/mc.23238
Yan, B, Chen, Q, Xu, J, Li, W, Xu, B & Qiu, Y 2020, 'Low-frequency TP53 hotspot mutation contributes to chemoresistance through clonal expansion in acute myeloid leukemia', Leukemia, vol. 34, no. 7, pp. 1816-1827. https://doi.org/10.1038/s41375-020-0710-7
Kim, MY, Yan, B, Huang, S & Qiu, Y 2020, 'Regulating the regulators: The role of histone deacetylase 1 (hdac1) in erythropoiesis', International journal of molecular sciences, vol. 21, no. 22, 8460, pp. 1-22. https://doi.org/10.3390/ijms21228460

2019

Luo, H, Zhu, G, Xu, J, Lai, Q, Yan, B, Guo, Y, Fung, TK, Zeisig, BB, Cui, Y, Zha, J, Cogle, C, Wang, F, Xu, B, Yang, FC, Li, W, So, CWE, Qiu, Y, Xu, M & Huang, S 2019, 'HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice', Cancer Cell, vol. 36, no. 6, pp. 645-659.e8. https://doi.org/10.1016/j.ccell.2019.10.011
Luo, H, Sobh, A, Vulpe, CD, Brewer, E, Dovat, S, Qiu, Y & Huang, S 2019, 'HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries', Journal of visualized experiments : JoVE, no. 145. https://doi.org/10.3791/59382

2018

Luo, H, Wang, F, Zha, J, Li, H, Yan, B, Du, Q, Yang, F, Sobh, A, Vulpe, C, Drusbosky, L, Cogle, C, Chepelev, I, Xu, B, Nimer, SD, Licht, J, Qiu, Y, Chen, B, Xu, M & Huang, S 2018, 'CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia', Blood, vol. 132, no. 8, pp. 837-848. https://doi.org/10.1182/blood-2017-11-814319
Yan, B, Chen, Q, Shimada, K, Tang, M, Li, H, Gurumurthy, A, Khoury, JD, Xu, B, Huang, S & Qiu, Y 2019, 'Histone deacetylase inhibitor targets CD123/CD47-positive cells and reverse chemoresistance phenotype in acute myeloid leukemia', Leukemia, vol. 33, no. 4, pp. 931-944. https://doi.org/10.1038/s41375-018-0279-6

2017

Qiu, Y & Huang, S 2017, 'Catching global interactions in vivo', Cell and Bioscience, vol. 7, no. 1, 49. https://doi.org/10.1186/s13578-017-0177-z
Jian, W, Yan, B, Huang, S & Qiu, Y 2017, 'Histone deacetylase 1 activates PU.1 gene transcription through regulating TAF9 deacetylation and transcription factor IID assembly', FASEB Journal, vol. 31, no. 9, pp. 4104-4116. https://doi.org/10.1096/fj.201700022R
Li, X, Mei, Y, Yan, B, Vitriol, E, Huang, S, Ji, P & Qiu, Y 2017, 'Histone deacetylase 6 regulates cytokinesis and erythrocyte enucleation through deacetylation of formin protein mDia2', Haematologica, vol. 102, no. 6, pp. 984-994. https://doi.org/10.3324/haematol.2016.161513

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