Researcher Profile

Researcher Profile

Yuka Imamura, PhD

Yuka Imamura, PhD

Associate Professor, Department of Pharmacology
Associate Professor, Department of Biochemistry and Molecular Biology
Penn State Neuroscience Institute
Scientific Program:Mechanisms of Carcinogenesis
yui102@psu.edu

Research Interests

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Dr. Yuka Imamura is director of Penn State College of Medicine's genome sciences facility. The facility provides a range of genetic, epigenetic and transcriptomic technologies to researchers from across Penn State. In addition to overseeing day-to-day operation of the facility, Dr. Imamura collaborates with a variety of biomedical researchers to aid in successful completion of their research projects.

She is also involved in University-wide efforts in genomics and personalized medicine, including research in conjunction with Penn State Clinical and Translational Science Institute, Penn State Cancer Institute, Penn State Heart and Vascular Institute and the Huck Institutes for the Life Sciences. She plays a key role in promoting the application of genomics research in medical science and in stimulating translational and clinical research into personalized health care.

  • Genes
  • Proteins
  • Brain
  • Neoplasms
  • Gene Expression
  • Messenger RNA
  • RNA
  • Transcriptome
  • Carcinogenesis
  • B-Lymphocytes
  • Population
  • Neurons
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Recent Publications

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2020

Chen, KM, Sun, YW, Kawasawa, YI, Salzberg, AC, Zhu, J, Gowda, K, Aliaga, C, Amin, S, Atkins, H & El-Bayoumy, K 2020, 'Black raspberry inhibits oral tumors in mice treated with the tobacco smoke constituent dibenzo(def,p)chrysene via genetic and epigenetic alterations', Cancer Prevention Research, vol. 13, no. 4, pp. 357-365. https://doi.org/10.1158/1940-6207.CAPR-19-0496
Forbes, TA, Goldstein, EZ, Dupree, JL, Jablonska, B, Scafidi, J, Adams, KL, Imamura, Y, Hashimoto-Torii, K & Gallo, V 2020, 'Environmental enrichment ameliorates perinatal brain injury and promotes functional white matter recovery', Nature communications, vol. 11, no. 1, 964. https://doi.org/10.1038/s41467-020-14762-7
Koscsó, B, Kurapati, S, Rodrigues, RR, Nedjic, J, Gowda, K, Shin, C, Soni, C, Ashraf, AZ, Purushothaman, I, Palisoc, M, Xu, S, Sun, H, Chodisetti, SB, Lin, E, Mack, M, Kawasawa, YI, He, P, Rahman, ZSM, Aifantis, I, Shulzhenko, N, Morgun, A & Bogunovic, M 2020, 'Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ', Science Immunology, vol. 5, no. 46, eaax0062. https://doi.org/10.1126/sciimmunol.aax0062
Mohammad, S, Page, SJ, Wang, L, Ishii, S, Li, P, Sasaki, T, Basha, A, Salzberg, A, Quezado, Z, Imamura, F, Nishi, H, Isaka, K, Corbin, JG, Liu, JS, Kawasawa, YI, Torii, M & Hashimoto-Torii, K 2020, 'Kcnn2 blockade reverses learning deficits in a mouse model of fetal alcohol spectrum disorders', Nature Neuroscience, vol. 23, no. 4, pp. 533-543. https://doi.org/10.1038/s41593-020-0592-z
Uchigashima, M, Leung, M, Watanabe, T, Cheung, A, Le, T, Pallat, S, Dinis, ALM, Watanabe, M, Kawasawa, YI & Futai, K 2020, 'Neuroligin3 splice isoforms shape inhibitory synaptic function in the mouse hippocampus', Journal of Biological Chemistry, vol. 295, no. 25. https://doi.org/10.1074/jbc.ac120.012571
Schneider, AM, Cook, LC, Zhan, X, Banerjee, K, Cong, Z, Imamura-Kawasawa, Y, Gettle, SL, Longenecker, AL, Kirby, JS & Nelson, AM 2020, 'Response to Ring et al. In Silico Predictive Metagenomic Analyses Highlight Key Metabolic Pathways Impacted in the Hidradenitis Suppurativa Skin Microbiome', Journal of Investigative Dermatology, vol. 140, no. 7, pp. 1476-1479. https://doi.org/10.1016/j.jid.2020.02.003
Thorenoor, N, Imamura, Y, Gandhi, CK & Floros, J 2020, 'Sex-Specific Regulation of Gene Expression Networks by Surfactant Protein A (SP-A) Variants in Alveolar Macrophages in Response to Klebsiella pneumoniae', Frontiers in immunology, vol. 11, 1290. https://doi.org/10.3389/fimmu.2020.01290
Chen, SJ, Bao, L, Keefer, K, Shanmughapriya, S, Chen, L, Lee, J, Wang, JF, Zhang, XQ, Hirschler-Laszkiewicz, I, Merali, S, Merali, C, Imamura, Y, Dovat, S, Madesh, M, Cheung, JY, Wang, HG & Miller, BA 2020, 'Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy', Cell Death and Disease, vol. 11, no. 4, 247. https://doi.org/10.1038/s41419-020-2454-8
Chodisetti, SB, Fike, AJ, Domeier, PP, Singh, H, Choi, NM, Corradetti, C, Kawasawa, YI, Cooper, TK, Caricchio, R & Rahman, ZSM 2020, 'Type II but not type I IFN signaling is indispensable for TLR7-promoted development of autoreactive B cells and systemic autoimmunity', Journal of Immunology, vol. 204, no. 4, pp. 796-809. https://doi.org/10.4049/jimmunol.1901175
Garcia, SA, Tian, H, Imamura-Kawasawa, Y, Fisher, A, Cellini, A, Codd, C, Herzenberg, JE, Abzug, JM, Ng, V, Iwamoto, M & Enomoto-Iwamoto, M 2020, 'Understanding the action of rarγ agonists on human osteochondroma explants', International journal of molecular sciences, vol. 21, no. 8, 2686. https://doi.org/10.3390/ijms21082686

2019

Gonzalez-Lopez, E, Kawasawa-Imamura, Y, Zhang, L, Huang, X, Koltun, WA, Coates, MD & Vrana, KE 2019, 'A single nucleotide polymorphism in dopamine beta hydroxylase (rs6271(C>T)) is over-represented in inflammatory bowel disease patients and reduces circulating enzyme', PloS one, vol. 14, no. 2, e0210175. https://doi.org/10.1371/journal.pone.0210175
He, F, Berg, A, Imamura Kawasawa, Y, Bixler, EO, Fernandez-Mendoza, J, Whitsel, EA & Liao, D 2019, 'Association between DNA methylation in obesity-related genes and body mass index percentile in adolescents', Scientific reports, vol. 9, no. 1, 2079. https://doi.org/10.1038/s41598-019-38587-7
Liu, Z, Yee, PP, Wei, Y, Liu, Z, Imamura, Y & Li, W 2019, 'Differential YAP expression in glioma cells induces cell competition and promotes tumorigenesis', Journal of Cell Science, vol. 132, no. 5, jcs225714. https://doi.org/10.1242/jcs.225714
Thorenoor, N, Kawasawa, YI, Gandhi, CK, Zhang, X & Floros, J 2019, 'Differential impact of co-expressed SP-A1/SP-A2 protein on AM miRNome; Sex differences', Frontiers in immunology, vol. 10, no. AUG, 1960. https://doi.org/10.3389/fimmu.2019.01960
Teissier, A, Le Magueresse, C, Olusakin, J, Andrade da Costa, BLS, De Stasi, AM, Bacci, A, Imamura Kawasawa, Y, Vaidya, VA & Gaspar, P 2020, 'Early-life stress impairs postnatal oligodendrogenesis and adult emotional behaviour through activity-dependent mechanisms', Molecular Psychiatry, vol. 25, no. 6, pp. 1159-1174. https://doi.org/10.1038/s41380-019-0493-2
Janicki, P, Eyileten, C, Ruiz-Velasco, V, Pordzik, J, Czlonkowska, A, Kurkowska-Jastrzebska, I, Sugino, S, Imamura, Y, Mirowska-Guzel, D & Postula, M 2019, 'Increased burden of rare deleterious variants of the KCNQ1 gene in patients with large‑vessel ischemic stroke', Molecular medicine reports, vol. 19, no. 4, pp. 3263-3272. https://doi.org/10.3892/mmr.2019.9987
Schneider, AM, Cook, LC, Zhan, X, Banerjee, K, Cong, Z, Imamura-Kawasawa, Y, Gettle, SL, Longenecker, AL, Kirby, JS & Nelson, AM 2020, 'Loss of Skin Microbial Diversity and Alteration of Bacterial Metabolic Function in Hidradenitis Suppurativa', Journal of Investigative Dermatology, vol. 140, no. 3, pp. 716-720. https://doi.org/10.1016/j.jid.2019.06.151
Pool, C, Walter, V, Bann, D, Goldenberg, D, Broach, J, Hennessy, M, Cottrill, E, Washburn, E, Williams, N, Crist, H, Imamura, Y & Warrick, JI 2019, 'Molecular characterization of tumors meeting diagnostic criteria for the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)', Virchows Archiv, vol. 474, no. 3, pp. 341-351. https://doi.org/10.1007/s00428-018-02512-6
Dierschke, SK, Miller, WP, Favate, JS, Shah, P, Kawasawa, YI, Salzberg, AC, Kimball, SR, Jefferson, LS & Dennis, MD 2019, 'O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1 dependent mitochondrial dysfunction in the retina', Journal of Biological Chemistry, vol. 294, no. 14, pp. 5508-5520. https://doi.org/10.1074/jbc.RA119.007494
Han, Q, Ma, J, Gu, Y, Song, H, Kapadia, M, Kawasawa, YI, Dovat, S, Song, C & Ge, Z 2019, 'RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute lymphoblastic leukemia', Journal of Cancer, vol. 10, no. 16, pp. 3842-3850. https://doi.org/10.7150/jca.33989
Olsen, NJ, Benko, AL, McAloose, CA, Becker, PM, Wright, D, Sunyer, T, Kawasawa, YI & Kovacs, WJ 2019, 'Repository corticotropin injection reverses critical elements of the TLR9/B cell receptor activation response in human B cells in vitro', Clinical Immunology, vol. 201, pp. 70-78. https://doi.org/10.1016/j.clim.2019.02.009
Yamashita, H, Kawasawa, YI, Shuman, L, Zheng, Z, Tran, T, Walter, V, Warrick, JI, Chen, G, Al-Ahmadie, H, Kaag, M, Wong, PK, Raman, JD & DeGraff, DJ 2019, 'Repression of transcription factor AP-2 alpha by PPARγ reveals a novel transcriptional circuit in basal-squamous bladder cancer', Oncogenesis, vol. 8, no. 12, 69. https://doi.org/10.1038/s41389-019-0178-3
Buj, R, Chen, CW, Dahl, ES, Leon, KE, Kuskovsky, R, Maglakelidze, N, Navaratnarajah, M, Zhang, G, Doan, MT, Jiang, H, Zaleski, M, Kutzler, L, Lacko, H, Lu, Y, Mills, GB, Gowda, R, Robertson, GP, Warrick, JI, Herlyn, M, Imamura, Y, Kimball, SR, DeGraff, DJ, Snyder, NW & Aird, KM 2019, 'Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming', Cell Reports, vol. 28, no. 8, pp. 1971-1980.e8. https://doi.org/10.1016/j.celrep.2019.07.084
Dahl, ES, Buj, R, Leon, KE, Newell, JM, Imamura, Y, Bitler, BG, Snyder, NW & Aird, KM 2019, 'Targeting IDH1 as a prosenescent therapy in high-grade serous ovarian cancer', Molecular Cancer Research, vol. 17, no. 8, pp. 1710-1720. https://doi.org/10.1158/1541-7786.MCR-18-1233
Eshelman, MA, Matthews, SM, Schleicher, EM, Fleeman, RM, Kawasawa, YI, Stumpo, DJ, Blackshear, PJ, Koltun, WA, Ishmael, FT & Yochum, GS 2019, 'Tristetraprolin targets Nos2 expression in the colonic epithelium', Scientific reports, vol. 9, no. 1, 14413. https://doi.org/10.1038/s41598-019-50957-9
Takahashi, Y, Liang, X, Hattori, T, Tang, Z, He, H, Chen, H, Liu, X, Abraham, T, Imamura-Kawasawa, Y, Buchkovich, NJ, Young, MM & Wang, HG 2019, 'VPS37A directs ESCRT recruitment for phagophore closure', The Journal of cell biology, vol. 218, no. 10, pp. 3336-3354. https://doi.org/10.1083/jcb.201902170
Pajtler, KW, Wei, Y, Okonechnikov, K, Silva, PBG, Vouri, M, Zhang, L, Brabetz, S, Sieber, L, Gulley, M, Mauermann, M, Wedig, T, Mack, N, Imamura Kawasawa, Y, Sharma, T, Zuckermann, M, Andreiuolo, F, Holland, E, Maass, K, Körkel-Qu, H, Liu, HK, Sahm, F, Capper, D, Bunt, J, Richards, LJ, Jones, DTW, Korshunov, A, Chavez, L, Lichter, P, Hoshino, M, Pfister, SM, Kool, M, Li, W & Kawauchi, D 2019, 'YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis', Nature communications, vol. 10, no. 1, 3914. https://doi.org/10.1038/s41467-019-11884-5

2018

Wu, X, Gowda, NM, Kawasawa, YI & Gowda, DC 2018, 'A malaria protein factor induces IL-4 production by dendritic cells via PI3K–Akt–NF-B signaling independent of MyD88/ TRIF and promotes Th2 response', Journal of Biological Chemistry, vol. 293, no. 27, pp. 10425-10434. https://doi.org/10.1074/jbc.AC118.001720
Mao, W, Salzberg, AC, Uchigashima, M, Hasegawa, Y, Hock, H, Watanabe, M, Akbarian, S, Kawasawa, YI & Futai, K 2018, 'Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1', Cell Reports, vol. 23, no. 11, pp. 3209-3222. https://doi.org/10.1016/j.celrep.2018.05.028
Domeier, PP, Chodisetti, SB, Schell, SL, Imamura, Y, Fasnacht, MJ, Soni, C & Rahman, Z 2018, 'B-Cell-Intrinsic Type 1 Interferon Signaling Is Crucial for Loss of Tolerance and the Development of Autoreactive B Cells', Cell Reports, vol. 24, no. 2, pp. 406-418. https://doi.org/10.1016/j.celrep.2018.06.046
Mockus, TE, Shwetank, Lauver, MD, Ren, HM, Netherby, CS, Salameh, T, Kawasawa, YI, Yue, F, Broach, JR & Lukacher, AE 2018, 'CD4 T cells control development and maintenance of brain-resident CD8 T cells during polyomavirus infection', PLoS pathogens, vol. 14, no. 10, e1007365. https://doi.org/10.1371/journal.ppat.1007365
Podany, A, Rauchut, J, Wu, T, Kawasawa, YI, Wright, J, Lamendella, R, Soybel, DI & Kelleher, SL 2019, 'Excess Dietary Zinc Intake in Neonatal Mice Causes Oxidative Stress and Alters Intestinal Host–Microbe Interactions', Molecular Nutrition and Food Research, vol. 63, no. 3, 1800947. https://doi.org/10.1002/mnfr.201800947
Mrowczynski, OD, Madhankumar, AB, Sundstrom, JM, Zhao, Y, Kawasawa, YI, Slagle-Webb, B, Mau, C, Payne, RA, Rizk, EB, Zacharia, BE & Connor, JR 2018, 'Exosomes impact survival to radiation exposure in cell line models of nervous system cancer', Oncotarget, vol. 9, no. 90, pp. 36083-36101. https://doi.org/10.18632/oncotarget.26300
Halstead, ES, Umstead, TM, Davies, ML, Kawasawa, YI, Silveyra, P, Howyrlak, J, Yang, L, Guo, W, Hu, S, Hewage, EK & Chroneos, ZC 2018, 'GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization', Respiratory research, vol. 19, no. 1, pp. 3. https://doi.org/10.1186/s12931-017-0708-5
Shike, H, Kadry, Z, Imamura-Kawasawa, Y, Greene, W, Riley, T, Nathan, HM, Hasz, RD & Jain, A 2018, 'Hepatitis C virus (HCV) RNA level in plasma and kidney tissue in HCV antibody-positive donors: Quantitative comparison', Clinical Transplantation, vol. 32, no. 9, e13358. https://doi.org/10.1111/ctr.13358
Gonzalez-Lopez, E, Kawasawa, YI, Walter, V, Zhang, L, Koltun, WA, Huang, X, Vrana, KE & Coates, MD 2018, 'Homozygosity for the SCN10A polymorphism rs6795970 is associated with hypoalgesic inflammatory bowel disease phenotype', Frontiers in Medicine, vol. 5, no. NOV, 324. https://doi.org/10.3389/fmed.2018.00324
BrainSpan Consortium, PsychENCODE Consortium, PsychENCODE Developmental Subgroup & Kawasawa, YI 2018, 'Integrative functional genomic analysis of human brain development and neuropsychiatric risks', Science, vol. 362, no. 6420, 1264. https://doi.org/10.1126/science.aat7615
Hall, JB, Cong, Z, Imamura-Kawasawa, Y, Kidd, BA, Dudley, JT, Thiboutot, DM & Nelson, AM 2018, 'Isolation and Identification of the Follicular Microbiome: Implications for Acne Research', Journal of Investigative Dermatology, vol. 138, no. 9, pp. 2033-2040. https://doi.org/10.1016/j.jid.2018.02.038
Koduru, SV, Leberfinger, AN, Kawasawa, YI, Mahajan, M, Gusani, NJ, Sanyal, AJ & Ravnic, DJ 2018, 'Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno', Scientific reports, vol. 8, no. 1, 7967. https://doi.org/10.1038/s41598-018-26360-1
Schleicher, EM, Galvan, AM, Imamura-Kawasawa, Y, Moldovan, GL & Nicolae, CM 2018, 'PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress', Nucleic acids research, vol. 46, no. 17, pp. 8908-8916. https://doi.org/10.1093/nar/gky658
Benko, AL, McAloose, CA, Becker, PM, Wright, D, Sunyer, T, Kawasawa, YI, Olsen, NJ & Kovacs, WJ 2018, 'Repository corticotrophin injection exerts direct acute effects on human B cell gene expression distinct from the actions of glucocorticoids', Clinical and Experimental Immunology, vol. 192, no. 1, pp. 68-81. https://doi.org/10.1111/cei.13089
Zhu, Y, Sousa, AMM, Gao, T, Skarica, M, Li, M, Santpere, G, Esteller-Cucala, P, Juan, D, Ferrández-Peral, L, Gulden, FO, Yang, M, Miller, DJ, Marques-Bonet, T, Kawasawa, YI, Zhao, H & Sestan, N 2018, 'Spatiotemporal transcriptomic divergence across human and macaque brain development', Science, vol. 362, no. 6420, 1267. https://doi.org/10.1126/science.aat8077
Tebbenkamp, ATN, Varela, L, Choi, J, Paredes, MI, Giani, AM, Song, JE, Sestan-Pesa, M, Franjic, D, Sousa, AMM, Liu, ZW, Li, M, Bichsel, C, Koch, M, Szigeti-Buck, K, Liu, F, Li, Z, Kawasawa, YI, Paspalas, CD, Mineur, YS, Prontera, P, Merla, G, Picciotto, MR, Arnsten, AFT, Horvath, TL & Sestan, N 2018, 'The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development', Cell, vol. 175, no. 4, pp. 1088-1104.e23. https://doi.org/10.1016/j.cell.2018.09.014
Meng, Q, Wang, K, Brunetti, T, Xia, Y, Jiao, C, Dai, R, Fitzgerald, D, Thomas, A, Jay, L, Eckart, H, Grennan, K, Imamura-Kawasawa, Y, Li, M, Sestan, N, White, KP, Chen, C & Liu, C 2018, 'The DGCR5 long noncoding RNA may regulate expression of several schizophrenia-related genes', Science Translational Medicine, vol. 10, no. 472, eaat6912. <https://stm.sciencemag.org/content/10/472/eaat6912>
Bellon, A, Wegener, A, Lescallette, AR, Valente, M, Yang, SK, Gardette, R, Matricon, J, Mouaffak, F, Watts, P, Vimeux, L, Yun, JK, Kawasawa, YI, Clawson, GA, Blandin, E, Chaumette, B, Jay, TM, Krebs, MO, Feuillet, V & Hosmalin, A 2018, 'Transdifferentiation of Human Circulating Monocytes Into Neuronal-Like Cells in 20 Days and Without Reprograming', Frontiers in Molecular Neuroscience, vol. 11, 323. https://doi.org/10.3389/fnmol.2018.00323
Wang, Q, Geng, Z, Gong, Y, Warren, K, Zheng, H, Imamura, Y & Gao, Z 2018, 'WDR68 is essential for the transcriptional activation of the PRC1-AUTS2 complex and neuronal differentiation of mouse embryonic stem cells', Stem Cell Research, vol. 33, pp. 206-214. https://doi.org/10.1016/j.scr.2018.10.023

2017

Clawson, GA, Matters, GL, Xin, P, McGovern, C, Wafula, E, DePamphilis, C, Meckley, M, Wong, J, Stewart, L, D’Jamoos, C, Altman, N, Kawasawa, YI, Du, Z, Honaas, L & Abraham, T 2017, '"Stealth dissemination" of macrophage-tumor cell fusions cultured from blood of patients with pancreatic ductal adenocarcinoma', PloS one, vol. 12, no. 9, e0184451. https://doi.org/10.1371/journal.pone.0184451
Koduru, SV, Tiwari, AK, Leberfinger, A, Hazard, SW, Kawasawa, YI, Mahajan, M & Ravnic, DJ 2017, 'A comprehensive NGS data analysis of differentially regulated miRNAs, piRNAs, lncRNas and sn/snoRNAs in triple negative breast cancer', Journal of Cancer, vol. 8, no. 4, pp. 578-596. https://doi.org/10.7150/jca.17633
Gu, Z, Kalamboglas, J, Yoshioka, S, Han, W, Li, Z, Kawasawa, YI, Pochareddy, S, Li, Z, Liu, F, Xu, X, Wijeratne, S, Ueno, M, Blatz, E, Salomone, J, Kumanogoh, A, Rasin, MR, Gebelein, B, Weirauch, MT, Sestan, N, Martin, JH & Yoshida, Y 2017, 'Control of species-dependent cortico-motoneuronal connections underlying manual dexterity', Science, vol. 357, no. 6349, pp. 400-404. https://doi.org/10.1126/science.aan3721
Serfass, JM, Takahashi, Y, Zhou, Z, Kawasawa, YI, Liu, Y, Tsotakos, N, Young, MM, Tang, Z, Yang, L, Atkinson, JM, Chroneos, ZC & Wang, HG 2017, 'Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection', Journal of Biological Chemistry, vol. 292, no. 24, pp. 10097-10111. https://doi.org/10.1074/jbc.M117.792747
Kawasawa, YI, Mohammad, S, Son, AI, Morizono, H, Basha, A, Salzberg, AC, Torii, M & Hashimoto-Torii, K 2017, 'Genome-wide profiling of differentially spliced mRNAs in human fetal cortical tissue exposed to alcohol', Alcohol, vol. 62, pp. 1-9. https://doi.org/10.1016/j.alcohol.2017.05.001
Sun, YW, Chen, KM, Kawasawa, YI, Salzberg, AC, Cooper, TK, Caruso, C, Aliaga, C, Zhu, J, Gowda, K, Amin, S & El-Bayoumy, K 2017, 'Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene', PloS one, vol. 12, no. 10, e0186873. https://doi.org/10.1371/journal.pone.0186873
Sousa, AMM, Zhu, Y, Raghanti, MA, Kitchen, RR, Onorati, M, Tebbenkamp, ATN, Stutz, B, Meyer, KA, Li, M, Kawasawa, YI, Liu, F, Perez, RG, Mele, M, Carvalho, T, Skarica, M, Gulden, FO, Pletikos, M, Shibata, A, Stephenson, AR, Edler, MK, Ely, JJ, Elsworth, JD, Horvath, TL, Hof, PR, Hyde, TM, Kleinman, JE, Weinberger, DR, Reimers, M, Lifton, RP, Mane, SM, Noonan, JP, State, MW, Lein, ES, Knowles, JA, Marques-Bonet, T, Sherwood, CC, Gerstein, MB & Sestan, N 2017, 'Molecular and cellular reorganization of neural circuits in the human lineage', Science, vol. 358, no. 6366, pp. 1027-1032. https://doi.org/10.1126/science.aan3456
Teye, EK, Sido, A, Xin, P, Finnberg, NK, Gokare, P, Kawasawa, YI, Salzberg, AC, Shimko, S, Bayerl, M, Ehmann, WC, Claxton, DF, Rybka, WB, Drabick, JJ, Wang, HG, Abraham, T, El-Deiry, WS, Brodsky, RA, J.Hohl, R & Pu, JJ 2017, 'PIGN gene expression aberration is associated with genomic instability and leukemic progression in acute myeloid leukemia with myelodysplastic features', Oncotarget, vol. 8, no. 18, pp. 29887-29905. https://doi.org/10.18632/oncotarget.15136
Janicki, PK, Eyileten, C, Ruiz-Velasco, V, Sedeek, KA, Pordzik, J, Czlonkowska, A, Kurkowska-Jastrzebska, I, Sugino, S, Imamura-Kawasawa, Y, Mirowska-Guzel, D & Postula, M 2017, 'Population-specific associations of deleterious rare variants in coding region of P2RY1–P2RY12 purinergic receptor genes in large-vessel ischemic stroke patients', International journal of molecular sciences, vol. 18, no. 12, 2678. https://doi.org/10.3390/ijms18122678
Schieffer, KM, Choi, CS, Emrich, S, Harris, L, Deiling, S, Karamchandani, DM, Salzberg, A, Kawasawa, YI, Yochum, GS & Koltun, WA 2017, 'RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 313, no. 3, pp. G277-G284. https://doi.org/10.1152/ajpgi.00136.2017
Ishii, S, Torii, M, Son, AI, Rajendraprasad, M, Morozov, YM, Kawasawa, YI, Salzberg, AC, Fujimoto, M, Brennand, K, Nakai, A, Mezger, V, Gage, FH, Rakic, P & Hashimoto-Torii, K 2017, 'Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling', Nature communications, vol. 8, 15157. https://doi.org/10.1038/ncomms15157
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