Navigation Menu

Clinical Trial External Search

Children (age < 18 years)
Adults (age >= 18 years)

Researcher Profile

Researcher Display

Song Tan

Song Tan

Professor, Biochemistry & Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Nucleosomes
  • Histones
  • Proteins
  • Chromatin
  • Yeasts
  • DNA
  • Histone Acetyltransferases
  • Acetylation
  • Enzymes
  • Genes
  • Transcription Factors
  • Escherichia coli

Recent Publications


Donovan, BT, Chen, H, Eek, P, Meng, Z, Jipa, C, Tan, S, Bai, L & Poirier, MG 2023, 'Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions', Molecular cell, vol. 83, no. 8, pp. 1251-1263.e6.
Chio, US, Rechiche, O, Bryll, AR, Zhu, J, Leith, EM, Feldman, JL, Peterson, CL, Tan, S & Armache, JP 2023, 'Cryo-EM structure of the human Sirtuin 6–nucleosome complex', Science Advances, vol. 9, no. 15, eadf7586.
Namitz, KEW, Tan, S & Cosgrove, MS 2023, 'Hierarchical assembly of the MLL1 core complex regulates H3K4 methylation and is dependent on temperature and component concentration', Journal of Biological Chemistry, vol. 299, no. 2, 102874.


McGinty, RK & Tan, S 2021, 'Principles of nucleosome recognition by chromatin factors and enzymes', Current Opinion in Structural Biology, vol. 71, pp. 16-26.
Santilli, RT, Williamson, JE, Shibata, Y, Sowers, RP, Fleischman, AN & Tan, S 2021, 'The Penn State Protein Ladder system for inexpensive protein molecular weight markers', Scientific reports, vol. 11, no. 1, 16703.


Kim, SA, Zhu, J, Yennawar, N, Eek, P & Tan, S 2020, 'Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate', Molecular cell, vol. 78, no. 5, pp. 903-914.e4.
Lehmann, LC, Bacic, L, Hewitt, G, Brackmann, K, Sabantsev, A, Gaullier, G, Pytharopoulou, S, Degliesposti, G, Okkenhaug, H, Tan, S, Costa, A, Skehel, JM, Boulton, SJ & Deindl, S 2020, 'Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch', Cell Reports, vol. 33, no. 12, 108529.
Espinola-Lopez, JM & Tan, S 2021, 'The Ada2/Ada3/Gcn5/Sgf29 histone acetyltransferase module', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1864, no. 2, 194629.