Song Tan - Penn State Cancer Institute
Researcher Profile
Song Tan
Professor, Biochemistry & Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2026
Borges, RL, González-Blanco, G, Arigela, H, Huang, Y, Caeiro, LD, Fattakhov, N, Lepore, S, Garcia-Martinez, L, Maurice, M, Mehta, PD, Park, EJ, MacGillivray, K, Nehru, J, Chau, M, Robayo, MC, Abad, C, Bilbao-Martinez, A, Monteiro, F, Luo, X, Tan, S, Bilbao, D, Sidoli, S, Di Stefano, B, Walz, K, Saltzman, AL, Verdun, RE, Shiekhattar, R & Morey, L 2026, 'Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders', Molecular cell, vol. 86, no. 4, pp. 604-624.e16. https://doi.org/10.1016/j.molcel.2026.01.023
2025
Gao, J, Li, H, Tan, S, Zhou, R & Lee, TH 2025, 'Roles of histone chaperone Nap1 and histone acetylation in regulating phase-separation of nucleosome arrays', Nature communications, vol. 16, no. 1, 10672. https://doi.org/10.1038/s41467-025-65701-3
2024
Xu, C, Kleinschmidt, H, Yang, J, Leith, EM, Johnson, J, Tan, S, Mahony, S & Bai, L 2024, 'Systematic dissection of sequence features affecting binding specificity of a pioneer factor reveals binding synergy between FOXA1 and AP-1', Molecular cell, vol. 84, no. 15, pp. 2838-2855.e10. https://doi.org/10.1016/j.molcel.2024.06.022
2023
Donovan, BT, Chen, H, Eek, P, Meng, Z, Jipa, C, Tan, S, Bai, L & Poirier, MG 2023, 'Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions', Molecular cell, vol. 83, no. 8, pp. 1251-1263.e6. https://doi.org/10.1016/j.molcel.2023.03.006
Chio, US, Rechiche, O, Bryll, AR, Zhu, J, Leith, EM, Feldman, JL, Peterson, CL, Tan, S & Armache, JP 2023, 'Cryo-EM structure of the human Sirtuin 6–nucleosome complex', Science Advances, vol. 9, no. 15, eadf7586. https://doi.org/10.1126/sciadv.adf7586
Namitz, KEW, Tan, S & Cosgrove, MS 2023, 'Hierarchical assembly of the MLL1 core complex regulates H3K4 methylation and is dependent on temperature and component concentration', Journal of Biological Chemistry, vol. 299, no. 2, 102874. https://doi.org/10.1016/j.jbc.2023.102874