Song Tan - Penn State Cancer Institute
Researcher Profile
Song Tan
Professor, Biochemistry & Molecular Biology
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Nucleosomes
- Histones
- Proteins
- Chromatin
- Yeasts
- DNA
- Histone Acetyltransferases
- Acetylation
- Enzymes
- Genes
- Transcription Factors
- Escherichia coli
Recent Publications
2023
Donovan, BT, Chen, H, Eek, P, Meng, Z, Jipa, C, Tan, S, Bai, L & Poirier, MG 2023, 'Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions', Molecular cell, vol. 83, no. 8, pp. 1251-1263.e6. https://doi.org/10.1016/j.molcel.2023.03.006
Chio, US, Rechiche, O, Bryll, AR, Zhu, J, Leith, EM, Feldman, JL, Peterson, CL, Tan, S & Armache, JP 2023, 'Cryo-EM structure of the human Sirtuin 6–nucleosome complex', Science Advances, vol. 9, no. 15, eadf7586. https://doi.org/10.1126/sciadv.adf7586
Namitz, KEW, Tan, S & Cosgrove, MS 2023, 'Hierarchical assembly of the MLL1 core complex regulates H3K4 methylation and is dependent on temperature and component concentration', Journal of Biological Chemistry, vol. 299, no. 2, 102874. https://doi.org/10.1016/j.jbc.2023.102874
2021
McGinty, RK & Tan, S 2021, 'Principles of nucleosome recognition by chromatin factors and enzymes', Current Opinion in Structural Biology, vol. 71, pp. 16-26. https://doi.org/10.1016/j.sbi.2021.05.006
Santilli, RT, Williamson, JE, Shibata, Y, Sowers, RP, Fleischman, AN & Tan, S 2021, 'The Penn State Protein Ladder system for inexpensive protein molecular weight markers', Scientific reports, vol. 11, no. 1, 16703. https://doi.org/10.1038/s41598-021-96051-x
2020
Kim, SA, Zhu, J, Yennawar, N, Eek, P & Tan, S 2020, 'Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate', Molecular cell, vol. 78, no. 5, pp. 903-914.e4. https://doi.org/10.1016/j.molcel.2020.04.019
Lehmann, LC, Bacic, L, Hewitt, G, Brackmann, K, Sabantsev, A, Gaullier, G, Pytharopoulou, S, Degliesposti, G, Okkenhaug, H, Tan, S, Costa, A, Skehel, JM, Boulton, SJ & Deindl, S 2020, 'Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch', Cell Reports, vol. 33, no. 12, 108529. https://doi.org/10.1016/j.celrep.2020.108529
Espinola-Lopez, JM & Tan, S 2021, 'The Ada2/Ada3/Gcn5/Sgf29 histone acetyltransferase module', Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1864, no. 2, 194629. https://doi.org/10.1016/j.bbagrm.2020.194629