Navigation Menu

Clinical Trial External Search

Children (age < 18 years)
Adults (age >= 18 years)

Researcher Profile

Researcher Display

E. Scott Halstead, PhD, MD

E. Scott Halstead, PhD, MD

Associate Professor, Department of Pediatrics
Division of Critical Care Medicine
Scientific Program:Next-Generation Therapies

Research Interests

  • Pediatrics
  • Sepsis
  • Infections
  • Child
  • Macrophages
  • Lung
  • Mortality
  • Virus Diseases
  • Cytokines
  • Influenza A virus
  • Biomarkers
  • Ferritins

Recent Publications


Yau, E, Yang, L, Chen, Y, Umstead, TM, Stanley, AE, Halstead, ES, Gandhi, CK, Yewdell, JW & Chroneos, ZC 2024, 'SP-R210 isoforms of Myosin18A modulate endosomal sorting and recognition of influenza A virus infection in macrophages', Microbes and Infection, vol. 26, no. 3, 105280.


Bonavia, AS, Samuelsen, A, Liang, M, Hanson, J, McKeone, D, Chroneos, ZC & Halstead, ES 2023, 'Comparison of whole blood cytokine immunoassays for rapid, functional immune phenotyping in critically ill patients with sepsis', Intensive Care Medicine Experimental, vol. 11, no. 1, 70.
Yehya, N, Zinter, MS, Thompson, JM, Lim, MJ, Hanudel, MR, Alkhouli, MF, Wong, H, Alder, MN, McKeone, DJ, Halstead, ES, Sinha, P & Sapru, A 2023, 'Identification of molecular subphenotypes in two cohorts of paediatric ARDS', Thorax, vol. 79, no. 2, pp. 128-134.
Nguyen, J, Thompson, JM, Balcarcel, DR, Alder, MN, McKeone, DJ, Halstead, ES, Rowan, CM, Lindell, RB & Yehya, N 2023, 'Immunocompromised Children With Acute Respiratory Distress Syndrome Possess a Distinct Circulating Inflammatory Profile', Critical Care Explorations, vol. 5, no. 1, pp. E0844.
Paine, R, Chasse, R, Halstead, ES, Nfonoyim, J, Park, DJ, Byun, T, Patel, B, Molina-Pallete, G, Harris, ES, Garner, F, Simms, L, Ahuja, S, McManus, JL & Roychowdhury, DF 2023, 'Inhaled Sargramostim (Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor) for COVID-19-Associated Acute Hypoxemia: Results of the Phase 2, Randomized, Open-Label Trial (iLeukPulm)', Military medicine, vol. 188, no. 7-8, pp. E2629-E2638.
Han, L, Wu, X, Wang, O, Luan, X, Velander, WH, Aynardi, M, Halstead, ES, Bonavia, AS, Jin, R, Li, G, Li, Y, Wang, Y, Dong, C & Lei, Y 2023, 'Mesenchymal stromal cells and alpha-1 antitrypsin have a strong synergy in modulating inflammation and its resolution', Theranostics, vol. 13, no. 9, pp. 2843-2862.
Beheshti, R, Halstead, ES, Cusack, B & Hicks, SD 2023, 'Multi-Omic Factors Associated with Frequency of Upper Respiratory Infections in Developing Infants', International journal of molecular sciences, vol. 24, no. 2, 934.
Yau, E, Yang, L, Chen, Y, Umstead, TM, Atkins, H, Katz, ZE, Yewdell, JW, Gandhi, CK, Halstead, ES & Chroneos, ZC 2023, 'Surfactant protein A alters endosomal trafficking of influenza A virus in macrophages', Frontiers in immunology, vol. 14, 919800.


Gardner, MM, Kirschen, MP, Wong, HR, McKeone, DJ, Scott Halstead, E, Thompson, JM, Himebauch, AS, Topjian, AA & Yehya, N 2022, 'Biomarkers associated with mortality in pediatric patients with cardiac arrest and acute respiratory distress syndrome', Resuscitation, vol. 170, pp. 184-193.
Bonavia, AS, Samuelsen, A, Chroneos, ZC & Halstead, ES 2022, 'Comparison of Rapid Cytokine Immunoassays for Functional Immune Phenotyping', Frontiers in immunology, vol. 13, 940030.
Bonavia, AS, Samuelsen, A, Luthy, J & Halstead, ES 2022, 'Integrated machine learning approaches for flow cytometric quantification of myeloid-derived suppressor cells in acute sepsis', Frontiers in immunology, vol. 13, 1007016.
Beheshti, R, Halstead, ES, McKeone, D & Hicks, SD 2023, 'Multi-omic factors associated with future wheezing in infants', Pediatric Research, vol. 93, no. 3, pp. 579-585.
Beheshti, R, Halstead, S, McKeone, D & Hicks, SD 2022, 'Understanding immunological origins of atopic dermatitis through multi-omic analysis', Pediatric Allergy and Immunology, vol. 33, no. 6, e13817.


McKeone, DJ, DeMartini, TKM, Kavanagh, RP & Halstead, ES 2021, 'Case Report: Rapid Recognition and Immune Modulation of Secondary HLH Due to Disseminated HSV Infection', Frontiers in Pediatrics, vol. 9, 681055.
Simonson, AW, Umstead, TM, Lawanprasert, A, Klein, B, Almarzooqi, S, Halstead, ES & Medina, SH 2021, 'Extracellular matrix-inspired inhalable aerogels for rapid clearance of pulmonary tuberculosis', Biomaterials, vol. 273, 120848.
American Thoracic Society Assembly on Pulmonary Infection and Tuberculosis 2021, 'Understanding the host in the management of pneumonia: An official American thoracic society workshop report', Annals of the American Thoracic Society, vol. 18, no. 7, pp. 1087-1097.


McKeone, DJ, Mathewson, M, Dalal, PG, Spear, D, Umstead, TM, Hicks, SD, Chroneos, ZC, Wang, M, Thomas, NJ & Halstead, ES 2020, 'Cytokine Panels and Pediatric Acute Respiratory Distress Syndrome: A Translational Investigation*', Pediatric Critical Care Medicine, vol. 21, no. 12, pp. E1084-E1093.
Moku, P, Shepherd, L, Ali, SM, Leitzel, K, Parulekar, WR, Zhu, L, Virk, S, Nomikos, D, Aparicio, S, Gelmon, K, Drabick, J, Cream, L, Halstead, ES, Umstead, TM, Mckeone, D, Polimera, H, Maddukuri, A, Ali, A, Nagabhairu, V, Poulose, J, Pancholy, N, Spiegel, H, Chen, BE & Lipton, A 2020, 'Higher serum PD-L1 level predicts increased overall survival with lapatinib versus trastuzumab in the CCTG MA.31 phase 3 trial', Cancer, vol. 126, no. 22, pp. 4859-4866.
Umstead, TM, Hewage, EK, Mathewson, M, Beaudoin, S, Chroneos, ZC, Wang, M & Halstead, ES 2020, 'Lower respiratory tract delivery, airway clearance, and preclinical efficacy of inhaled GM-CSF in a postinfluenza pneumococcal pneumonia model', American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 318, no. 4, pp. L571-L579.