Researcher Profile

Researcher Profile

E. Scott Halstead, PhD, MD

E. Scott Halstead, PhD, MD

Associate Professor, Department of Pediatrics
Division of Critical Care Medicine
Scientific Program:Next-Generation Therapies
euh4@psu.edu

Research Interests

  • Pediatrics
  • Sepsis
  • Infection
  • Child
  • Lung
  • Ferritins
  • Virus Diseases
  • Macrophages
  • Mortality
  • Influenza A virus
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Serum

Recent Publications

2020

McKeone, DJ, Mathewson, M, Dalal, PG, Spear, D, Umstead, TM, Hicks, SD, Chroneos, ZC, Wang, M, Thomas, NJ & Halstead, ES 2020, 'Cytokine Panels and Pediatric Acute Respiratory Distress Syndrome: A Translational Investigation∗', Pediatric Critical Care Medicine, pp. E1084-E1093. https://doi.org/10.1097/PCC.0000000000002531
Moku, P, Shepherd, L, Ali, SM, Leitzel, K, Parulekar, WR, Zhu, L, Virk, S, Nomikos, D, Aparicio, S, Gelmon, K, Drabick, J, Cream, L, Halstead, ES, Umstead, TM, Mckeone, D, Polimera, H, Maddukuri, A, Ali, A, Nagabhairu, V, Poulose, J, Pancholy, N, Spiegel, H, Chen, BE & Lipton, A 2020, 'Higher serum PD-L1 level predicts increased overall survival with lapatinib versus trastuzumab in the CCTG MA.31 phase 3 trial', Cancer, vol. 126, no. 22, pp. 4859-4866. https://doi.org/10.1002/cncr.33149
Umstead, TM, Hewage, EK, Mathewson, M, Beaudoin, S, Chroneos, ZC, Wang, M & Halstead, ES 2020, 'Lower respiratory tract delivery, airway clearance, and preclinical efficacy of inhaled GM-CSF in a postinfluenza pneumococcal pneumonia model', American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 318, no. 4, pp. L571-L579. https://doi.org/10.1152/AJPLUNG.00296.2019

2019

Simon, DW, Halstead, ES, Davila, S, Kernan, KF, Clark, RSB, Storch, G & Carcillo, JA 2019, 'DNA Viremia Is Associated with Hyperferritinemia in Pediatric Sepsis', Journal of Pediatrics, vol. 213, pp. 82-87.e2. https://doi.org/10.1016/j.jpeds.2019.06.033

2018

Halstead, ES, Umstead, TM, Davies, ML, Kawasawa, YI, Silveyra, P, Howyrlak, J, Yang, L, Guo, W, Hu, S, Hewage, EK & Chroneos, ZC 2018, 'GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization', Respiratory research, vol. 19, no. 1, pp. 3. https://doi.org/10.1186/s12931-017-0708-5
Park, K, Trout, LC, Xu, C, Wang, M, Tamburro, RF & Halstead, ES 2018, 'No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children', Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, vol. 19, no. 8, pp. e425-e432. https://doi.org/10.1097/PCC.0000000000001608
Pediatric Brain Injury Research Network (PediBIRN) Investigators 2018, 'Racial and Ethnic Disparities and Bias in the Evaluation and Reporting of Abusive Head Trauma', Journal of Pediatrics, vol. 198, pp. 137-143.e1. https://doi.org/10.1016/j.jpeds.2018.01.048
Davila, S, Halstead, ES, Hall, MW, Doctor, A, Telford, R, Holubkov, R, Carcillo, JA & Storch, GA 2018, 'Viral DNAemia and Immune Suppression in Pediatric Sepsis', Pediatric Critical Care Medicine, vol. 19, no. 1, pp. e14-e22. https://doi.org/10.1097/PCC.0000000000001376

2017

Carcillo, JA, Sward, K, Halstead, ES, Telford, R, Jimenez-Bacardi, A, Shakoory, B, Simon, D & Hall, M 2017, 'A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis∗', Pediatric Critical Care Medicine, vol. 18, no. 2, pp. 143-150. https://doi.org/10.1097/PCC.0000000000001029
Kurundu Hewage, EMK, Spear, D, Umstead, TM, Hu, S, Wang, M, Wong, PK, Chroneos, ZC, Halstead, ES & Thomas, NJ 2017, 'An Electrochemical Biosensor for Rapid Detection of Pediatric Bloodstream Infections', SLAS Technology, vol. 22, no. 6, pp. 616-625. https://doi.org/10.1177/2472630317727704
Krawiec, C, Ballinger, K & Halstead, ES 2017, 'Intrapulmonary percussive ventilation as an airway clearance technique during venoarterial extracorporeal life support in an infant with pertussis', Frontiers in Pediatrics, vol. 5, 99. https://doi.org/10.3389/fped.2017.00099
Fino, KK, Yang, L, Silveyra, P, Hu, S, Umstead, TM, Diangelo, S, Halstead, ES, Cooper, TK, Abraham, T, Takahashi, Y, Zhou, Z, Wang, HG & Chroneos, ZC 2017, 'SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection', Scientific reports, vol. 7, no. 1, 7262. https://doi.org/10.1038/s41598-017-07724-5
Carcillo, JA, Halstead, ES, Hall, MW, Nguyen, TC, Reeder, R, Aneja, R, Shakoory, B & Simon, D 2017, 'Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome', Pediatric Critical Care Medicine, vol. 18, no. 6, pp. 513-523. https://doi.org/10.1097/PCC.0000000000001122

Clinical Trials Search


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Adults (age >= 18 years)