Researcher Profile

Researcher Profile

E. Scott Halstead, PhD, MD

E. Scott Halstead, PhD, MD

Associate Professor, Department of Pediatrics
Division of Critical Care Medicine
Scientific Program:Next-Generation Therapies

Research Interests

  • Pediatrics
  • Sepsis
  • Infections
  • Lung
  • Child
  • Macrophages
  • Mortality
  • Ferritins
  • Virus Diseases
  • Influenza A virus
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Serum

Recent Publications


Gardner, MM, Kirschen, MP, Wong, HR, McKeone, DJ, Scott Halstead, E, Thompson, JM, Himebauch, AS, Topjian, AA & Yehya, N 2022, 'Biomarkers associated with mortality in pediatric patients with cardiac arrest and acute respiratory distress syndrome', Resuscitation, vol. 170, pp. 184-193.


McKeone, DJ, DeMartini, TKM, Kavanagh, RP & Halstead, ES 2021, 'Case Report: Rapid Recognition and Immune Modulation of Secondary HLH Due to Disseminated HSV Infection', Frontiers in Pediatrics, vol. 9, 681055.
Simonson, AW, Umstead, TM, Lawanprasert, A, Klein, B, Almarzooqi, S, Halstead, ES & Medina, SH 2021, 'Extracellular matrix-inspired inhalable aerogels for rapid clearance of pulmonary tuberculosis', Biomaterials, vol. 273, 120848.
American Thoracic Society Assembly on Pulmonary Infection and Tuberculosis 2021, 'Understanding the host in the management of pneumonia: An official American thoracic society workshop report', Annals of the American Thoracic Society, vol. 18, no. 7, pp. 1087-1097.


McKeone, DJ, Mathewson, M, Dalal, PG, Spear, D, Umstead, TM, Hicks, SD, Chroneos, ZC, Wang, M, Thomas, NJ & Halstead, ES 2020, 'Cytokine Panels and Pediatric Acute Respiratory Distress Syndrome: A Translational Investigation∗', Pediatric Critical Care Medicine, pp. E1084-E1093.
Moku, P, Shepherd, L, Ali, SM, Leitzel, K, Parulekar, WR, Zhu, L, Virk, S, Nomikos, D, Aparicio, S, Gelmon, K, Drabick, J, Cream, L, Halstead, ES, Umstead, TM, Mckeone, D, Polimera, H, Maddukuri, A, Ali, A, Nagabhairu, V, Poulose, J, Pancholy, N, Spiegel, H, Chen, BE & Lipton, A 2020, 'Higher serum PD-L1 level predicts increased overall survival with lapatinib versus trastuzumab in the CCTG MA.31 phase 3 trial', Cancer, vol. 126, no. 22, pp. 4859-4866.
Umstead, TM, Hewage, EK, Mathewson, M, Beaudoin, S, Chroneos, ZC, Wang, M & Halstead, ES 2020, 'Lower respiratory tract delivery, airway clearance, and preclinical efficacy of inhaled GM-CSF in a postinfluenza pneumococcal pneumonia model', American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 318, no. 4, pp. L571-L579.


Simon, DW, Halstead, ES, Davila, S, Kernan, KF, Clark, RSB, Storch, G & Carcillo, JA 2019, 'DNA Viremia Is Associated with Hyperferritinemia in Pediatric Sepsis', Journal of Pediatrics, vol. 213, pp. 82-87.e2.


Thorenoor, N, Zhang, X, Umstead, TM, Scott Halstead, E, Phelps, DS & Floros, J 2018, 'Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences', Respiratory research, vol. 19, no. 1, 23.
Halstead, ES, Umstead, TM, Davies, ML, Kawasawa, YI, Silveyra, P, Howyrlak, J, Yang, L, Guo, W, Hu, S, Hewage, EK & Chroneos, ZC 2018, 'GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization', Respiratory research, vol. 19, no. 1, pp. 3.
Park, K, Trout, LC, Xu, C, Wang, M, Tamburro, RF & Halstead, ES 2018, 'No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children', Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, vol. 19, no. 8, pp. e425-e432.
Pediatric Brain Injury Research Network (PediBIRN) Investigators 2018, 'Racial and Ethnic Disparities and Bias in the Evaluation and Reporting of Abusive Head Trauma', Journal of Pediatrics, vol. 198, pp. 137-143.e1.
Davila, S, Halstead, ES, Hall, MW, Doctor, A, Telford, R, Holubkov, R, Carcillo, JA & Storch, GA 2018, 'Viral DNAemia and Immune Suppression in Pediatric Sepsis', Pediatric Critical Care Medicine, vol. 19, no. 1, pp. e14-e22.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)