Researcher Profile

Researcher Profile

E. Scott Halstead, PhD, MD

E. Scott Halstead, PhD, MD

Associate Professor, Department of Pediatrics
Division of Critical Care Medicine
Scientific Program:Next-Generation Therapies

Research Interests

  • Pediatrics
  • Sepsis
  • Infections
  • Child
  • Macrophages
  • Lung
  • Ferritins
  • Virus Diseases
  • Mortality
  • Influenza A virus
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Serum

Recent Publications


Simonson, AW, Umstead, TM, Lawanprasert, A, Klein, B, Almarzooqi, S, Halstead, ES & Medina, SH 2021, 'Extracellular matrix-inspired inhalable aerogels for rapid clearance of pulmonary tuberculosis', Biomaterials, vol. 273, 120848.


McKeone, DJ, Mathewson, M, Dalal, PG, Spear, D, Umstead, TM, Hicks, SD, Chroneos, ZC, Wang, M, Thomas, NJ & Halstead, ES 2020, 'Cytokine Panels and Pediatric Acute Respiratory Distress Syndrome: A Translational Investigation∗', Pediatric Critical Care Medicine, pp. E1084-E1093.
Moku, P, Shepherd, L, Ali, SM, Leitzel, K, Parulekar, WR, Zhu, L, Virk, S, Nomikos, D, Aparicio, S, Gelmon, K, Drabick, J, Cream, L, Halstead, ES, Umstead, TM, Mckeone, D, Polimera, H, Maddukuri, A, Ali, A, Nagabhairu, V, Poulose, J, Pancholy, N, Spiegel, H, Chen, BE & Lipton, A 2020, 'Higher serum PD-L1 level predicts increased overall survival with lapatinib versus trastuzumab in the CCTG MA.31 phase 3 trial', Cancer, vol. 126, no. 22, pp. 4859-4866.
Umstead, TM, Hewage, EK, Mathewson, M, Beaudoin, S, Chroneos, ZC, Wang, M & Halstead, ES 2020, 'Lower respiratory tract delivery, airway clearance, and preclinical efficacy of inhaled GM-CSF in a postinfluenza pneumococcal pneumonia model', American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 318, no. 4, pp. L571-L579.


Simon, DW, Halstead, ES, Davila, S, Kernan, KF, Clark, RSB, Storch, G & Carcillo, JA 2019, 'DNA Viremia Is Associated with Hyperferritinemia in Pediatric Sepsis', Journal of Pediatrics, vol. 213, pp. 82-87.e2.


Halstead, ES, Umstead, TM, Davies, ML, Kawasawa, YI, Silveyra, P, Howyrlak, J, Yang, L, Guo, W, Hu, S, Hewage, EK & Chroneos, ZC 2018, 'GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization', Respiratory research, vol. 19, no. 1, pp. 3.
Park, K, Trout, LC, Xu, C, Wang, M, Tamburro, RF & Halstead, ES 2018, 'No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children', Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, vol. 19, no. 8, pp. e425-e432.
Pediatric Brain Injury Research Network (PediBIRN) Investigators 2018, 'Racial and Ethnic Disparities and Bias in the Evaluation and Reporting of Abusive Head Trauma', Journal of Pediatrics, vol. 198, pp. 137-143.e1.
Davila, S, Halstead, ES, Hall, MW, Doctor, A, Telford, R, Holubkov, R, Carcillo, JA & Storch, GA 2018, 'Viral DNAemia and Immune Suppression in Pediatric Sepsis', Pediatric Critical Care Medicine, vol. 19, no. 1, pp. e14-e22.


Carcillo, JA, Sward, K, Halstead, ES, Telford, R, Jimenez-Bacardi, A, Shakoory, B, Simon, D & Hall, M 2017, 'A Systemic Inflammation Mortality Risk Assessment Contingency Table for Severe Sepsis∗', Pediatric Critical Care Medicine, vol. 18, no. 2, pp. 143-150.
Kurundu Hewage, EMK, Spear, D, Umstead, TM, Hu, S, Wang, M, Wong, PK, Chroneos, ZC, Halstead, ES & Thomas, NJ 2017, 'An Electrochemical Biosensor for Rapid Detection of Pediatric Bloodstream Infections', SLAS Technology, vol. 22, no. 6, pp. 616-625.
Krawiec, C, Ballinger, K & Halstead, ES 2017, 'Intrapulmonary percussive ventilation as an airway clearance technique during venoarterial extracorporeal life support in an infant with pertussis', Frontiers in Pediatrics, vol. 5, 99.
Fino, KK, Yang, L, Silveyra, P, Hu, S, Umstead, TM, Diangelo, S, Halstead, ES, Cooper, TK, Abraham, T, Takahashi, Y, Zhou, Z, Wang, HG & Chroneos, ZC 2017, 'SH3GLB2/endophilin B2 regulates lung homeostasis and recovery from severe influenza A virus infection', Scientific reports, vol. 7, no. 1, 7262.
Carcillo, JA, Halstead, ES, Hall, MW, Nguyen, TC, Reeder, R, Aneja, R, Shakoory, B & Simon, D 2017, 'Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome', Pediatric Critical Care Medicine, vol. 18, no. 6, pp. 513-523.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)