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E. Scott Halstead, PhD, MD

E. Scott Halstead, PhD, MD

Associate Professor, Department of Pediatrics
Division of Critical Care Medicine
Scientific Program:Next-Generation Therapies
EUH4@psu.edu

Research Interests

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  • Pediatrics
  • Sepsis
  • Infections
  • Child
  • Macrophages
  • Lung
  • Mortality
  • Virus Diseases
  • Cytokines
  • Influenza A virus
  • Biomarkers
  • Ferritins
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Recent Publications

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2024

Yehya, N, Booth, TJ, Ardhanari, GD, Thompson, JM, Lam, LKM, Till, JE, Mai, MV, Keim, G, McKeone, DJ, Halstead, ES, Lahni, P, Varisco, BM, Zhou, W, Carpenter, EL, Christie, JD & Mangalmurti, NS 2024, 'Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome', Journal of Clinical Investigation, vol. 134, no. 10, e177896. https://doi.org/10.1172/JCI177896
Samuelsen, AM, Halstead, ES, Lehman, EB, McKeone, DJ & Bonavia, AS 2024, 'Predicting Organ Dysfunction in Septic and Critically Ill Patients: A Prospective Cohort Study Using Rapid Ex Vivo Immune Profiling', Critical Care Explorations, vol. 6, no. 7, 00008. https://doi.org/10.1097/CCE.0000000000001106
Yau, E, Yang, L, Chen, Y, Umstead, TM, Stanley, AE, Halstead, ES, Gandhi, CK, Yewdell, JW & Chroneos, ZC 2024, 'SP-R210 isoforms of Myosin18A modulate endosomal sorting and recognition of influenza A virus infection in macrophages', Microbes and Infection, vol. 26, no. 3, 105280. https://doi.org/10.1016/j.micinf.2023.105280

2023

Bonavia, AS, Samuelsen, A, Liang, M, Hanson, J, McKeone, D, Chroneos, ZC & Halstead, ES 2023, 'Comparison of whole blood cytokine immunoassays for rapid, functional immune phenotyping in critically ill patients with sepsis', Intensive Care Medicine Experimental, vol. 11, no. 1, 70. https://doi.org/10.1186/s40635-023-00556-w
Yehya, N, Zinter, MS, Thompson, JM, Lim, MJ, Hanudel, MR, Alkhouli, MF, Wong, H, Alder, MN, McKeone, DJ, Halstead, ES, Sinha, P & Sapru, A 2023, 'Identification of molecular subphenotypes in two cohorts of paediatric ARDS', Thorax, vol. 79, no. 2, pp. 128-134. https://doi.org/10.1136/thorax-2023-220130
Nguyen, J, Thompson, JM, Balcarcel, DR, Alder, MN, McKeone, DJ, Halstead, ES, Rowan, CM, Lindell, RB & Yehya, N 2023, 'Immunocompromised Children With Acute Respiratory Distress Syndrome Possess a Distinct Circulating Inflammatory Profile', Critical Care Explorations, vol. 5, no. 1, pp. E0844. https://doi.org/10.1097/CCE.0000000000000844
Paine, R, Chasse, R, Halstead, ES, Nfonoyim, J, Park, DJ, Byun, T, Patel, B, Molina-Pallete, G, Harris, ES, Garner, F, Simms, L, Ahuja, S, McManus, JL & Roychowdhury, DF 2023, 'Inhaled Sargramostim (Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor) for COVID-19-Associated Acute Hypoxemia: Results of the Phase 2, Randomized, Open-Label Trial (iLeukPulm)', Military medicine, vol. 188, no. 7-8, pp. E2629-E2638. https://doi.org/10.1093/milmed/usac362
Han, L, Wu, X, Wang, O, Luan, X, Velander, WH, Aynardi, M, Halstead, ES, Bonavia, AS, Jin, R, Li, G, Li, Y, Wang, Y, Dong, C & Lei, Y 2023, 'Mesenchymal stromal cells and alpha-1 antitrypsin have a strong synergy in modulating inflammation and its resolution', Theranostics, vol. 13, no. 9, pp. 2843-2862. https://doi.org/10.7150/thno.83942
Beheshti, R, Halstead, ES, Cusack, B & Hicks, SD 2023, 'Multi-Omic Factors Associated with Frequency of Upper Respiratory Infections in Developing Infants', International journal of molecular sciences, vol. 24, no. 2, 934. https://doi.org/10.3390/ijms24020934
Yau, E, Yang, L, Chen, Y, Umstead, TM, Atkins, H, Katz, ZE, Yewdell, JW, Gandhi, CK, Halstead, ES & Chroneos, ZC 2023, 'Surfactant protein A alters endosomal trafficking of influenza A virus in macrophages', Frontiers in immunology, vol. 14, 919800. https://doi.org/10.3389/fimmu.2023.919800

2022

Gardner, MM, Kirschen, MP, Wong, HR, McKeone, DJ, Scott Halstead, E, Thompson, JM, Himebauch, AS, Topjian, AA & Yehya, N 2022, 'Biomarkers associated with mortality in pediatric patients with cardiac arrest and acute respiratory distress syndrome', Resuscitation, vol. 170, pp. 184-193. https://doi.org/10.1016/j.resuscitation.2021.11.036
Bonavia, AS, Samuelsen, A, Chroneos, ZC & Halstead, ES 2022, 'Comparison of Rapid Cytokine Immunoassays for Functional Immune Phenotyping', Frontiers in immunology, vol. 13, 940030. https://doi.org/10.3389/fimmu.2022.940030
Bonavia, AS, Samuelsen, A, Luthy, J & Halstead, ES 2022, 'Integrated machine learning approaches for flow cytometric quantification of myeloid-derived suppressor cells in acute sepsis', Frontiers in immunology, vol. 13, 1007016. https://doi.org/10.3389/fimmu.2022.1007016
Beheshti, R, Halstead, ES, McKeone, D & Hicks, SD 2023, 'Multi-omic factors associated with future wheezing in infants', Pediatric Research, vol. 93, no. 3, pp. 579-585. https://doi.org/10.1038/s41390-022-02318-y
Beheshti, R, Halstead, S, McKeone, D & Hicks, SD 2022, 'Understanding immunological origins of atopic dermatitis through multi-omic analysis', Pediatric Allergy and Immunology, vol. 33, no. 6, e13817. https://doi.org/10.1111/pai.13817

2021

McKeone, DJ, DeMartini, TKM, Kavanagh, RP & Halstead, ES 2021, 'Case Report: Rapid Recognition and Immune Modulation of Secondary HLH Due to Disseminated HSV Infection', Frontiers in Pediatrics, vol. 9, 681055. https://doi.org/10.3389/fped.2021.681055
Simonson, AW, Umstead, TM, Lawanprasert, A, Klein, B, Almarzooqi, S, Halstead, ES & Medina, SH 2021, 'Extracellular matrix-inspired inhalable aerogels for rapid clearance of pulmonary tuberculosis', Biomaterials, vol. 273, 120848. https://doi.org/10.1016/j.biomaterials.2021.120848
American Thoracic Society Assembly on Pulmonary Infection and Tuberculosis 2021, 'Understanding the host in the management of pneumonia: An official American thoracic society workshop report', Annals of the American Thoracic Society, vol. 18, no. 7, pp. 1087-1097. https://doi.org/10.1513/AnnalsATS.202102-209ST

2020

McKeone, DJ, Mathewson, M, Dalal, PG, Spear, D, Umstead, TM, Hicks, SD, Chroneos, ZC, Wang, M, Thomas, NJ & Halstead, ES 2020, 'Cytokine Panels and Pediatric Acute Respiratory Distress Syndrome: A Translational Investigation*', Pediatric Critical Care Medicine, vol. 21, no. 12, pp. E1084-E1093. https://doi.org/10.1097/PCC.0000000000002531
Moku, P, Shepherd, L, Ali, SM, Leitzel, K, Parulekar, WR, Zhu, L, Virk, S, Nomikos, D, Aparicio, S, Gelmon, K, Drabick, J, Cream, L, Halstead, ES, Umstead, TM, Mckeone, D, Polimera, H, Maddukuri, A, Ali, A, Nagabhairu, V, Poulose, J, Pancholy, N, Spiegel, H, Chen, BE & Lipton, A 2020, 'Higher serum PD-L1 level predicts increased overall survival with lapatinib versus trastuzumab in the CCTG MA.31 phase 3 trial', Cancer, vol. 126, no. 22, pp. 4859-4866. https://doi.org/10.1002/cncr.33149
Umstead, TM, Hewage, EK, Mathewson, M, Beaudoin, S, Chroneos, ZC, Wang, M & Halstead, ES 2020, 'Lower respiratory tract delivery, airway clearance, and preclinical efficacy of inhaled GM-CSF in a postinfluenza pneumococcal pneumonia model', American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 318, no. 4, pp. L571-L579. https://doi.org/10.1152/AJPLUNG.00296.2019
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