E. Scott Halstead, PhD, MD - Penn State Cancer Institute
Researcher Profile
E. Scott Halstead, PhD, MD
Associate Professor, Department of Pediatrics
Division of Critical Care Medicine
Division of Critical Care Medicine
Scientific Program:Next-Generation Therapies
Research Interests
- Pediatrics
- Sepsis
- Infections
- Child
- Lung
- Mortality
- Macrophages
- Cytokines
- Biomarkers
- Ferritins
- Virus Diseases
- Adult Respiratory Distress Syndrome
Recent Publications
2023
Nguyen, J, Thompson, JM, Balcarcel, DR, Alder, MN, McKeone, DJ, Halstead, ES, Rowan, CM, Lindell, RB & Yehya, N 2023, 'Immunocompromised Children With Acute Respiratory Distress Syndrome Possess a Distinct Circulating Inflammatory Profile', Critical Care Explorations, vol. 5, no. 1, pp. E0844. https://doi.org/10.1097/CCE.0000000000000844
Beheshti, R, Halstead, ES, Cusack, B & Hicks, SD 2023, 'Multi-Omic Factors Associated with Frequency of Upper Respiratory Infections in Developing Infants', International journal of molecular sciences, vol. 24, no. 2, 934. https://doi.org/10.3390/ijms24020934
2022
Gardner, MM, Kirschen, MP, Wong, HR, McKeone, DJ, Scott Halstead, E, Thompson, JM, Himebauch, AS, Topjian, AA & Yehya, N 2022, 'Biomarkers associated with mortality in pediatric patients with cardiac arrest and acute respiratory distress syndrome', Resuscitation, vol. 170, pp. 184-193. https://doi.org/10.1016/j.resuscitation.2021.11.036
Bonavia, AS, Samuelsen, A, Chroneos, ZC & Halstead, ES 2022, 'Comparison of Rapid Cytokine Immunoassays for Functional Immune Phenotyping', Frontiers in immunology, vol. 13, 940030. https://doi.org/10.3389/fimmu.2022.940030
Bonavia, AS, Samuelsen, A, Luthy, J & Halstead, ES 2022, 'Integrated machine learning approaches for flow cytometric quantification of myeloid-derived suppressor cells in acute sepsis', Frontiers in immunology, vol. 13, 1007016. https://doi.org/10.3389/fimmu.2022.1007016
Beheshti, R, Halstead, ES, McKeone, D & Hicks, SD 2023, 'Multi-omic factors associated with future wheezing in infants', Pediatric Research, vol. 93, no. 3, pp. 579-585. https://doi.org/10.1038/s41390-022-02318-y
Beheshti, R, Halstead, S, McKeone, D & Hicks, SD 2022, 'Understanding immunological origins of atopic dermatitis through multi-omic analysis', Pediatric Allergy and Immunology, vol. 33, no. 6, e13817. https://doi.org/10.1111/pai.13817
2021
McKeone, DJ, DeMartini, TKM, Kavanagh, RP & Halstead, ES 2021, 'Case Report: Rapid Recognition and Immune Modulation of Secondary HLH Due to Disseminated HSV Infection', Frontiers in Pediatrics, vol. 9, 681055. https://doi.org/10.3389/fped.2021.681055
Simonson, AW, Umstead, TM, Lawanprasert, A, Klein, B, Almarzooqi, S, Halstead, ES & Medina, SH 2021, 'Extracellular matrix-inspired inhalable aerogels for rapid clearance of pulmonary tuberculosis', Biomaterials, vol. 273, 120848. https://doi.org/10.1016/j.biomaterials.2021.120848
American Thoracic Society Assembly on Pulmonary Infection and Tuberculosis 2021, 'Understanding the host in the management of pneumonia: An official American thoracic society workshop report', Annals of the American Thoracic Society, vol. 18, no. 7, pp. 1087-1097. https://doi.org/10.1513/AnnalsATS.202102-209ST
2020
McKeone, DJ, Mathewson, M, Dalal, PG, Spear, D, Umstead, TM, Hicks, SD, Chroneos, ZC, Wang, M, Thomas, NJ & Halstead, ES 2020, 'Cytokine Panels and Pediatric Acute Respiratory Distress Syndrome: A Translational Investigation∗', Pediatric Critical Care Medicine, pp. E1084-E1093. https://doi.org/10.1097/PCC.0000000000002531
Moku, P, Shepherd, L, Ali, SM, Leitzel, K, Parulekar, WR, Zhu, L, Virk, S, Nomikos, D, Aparicio, S, Gelmon, K, Drabick, J, Cream, L, Halstead, ES, Umstead, TM, Mckeone, D, Polimera, H, Maddukuri, A, Ali, A, Nagabhairu, V, Poulose, J, Pancholy, N, Spiegel, H, Chen, BE & Lipton, A 2020, 'Higher serum PD-L1 level predicts increased overall survival with lapatinib versus trastuzumab in the CCTG MA.31 phase 3 trial', Cancer, vol. 126, no. 22, pp. 4859-4866. https://doi.org/10.1002/cncr.33149
Umstead, TM, Hewage, EK, Mathewson, M, Beaudoin, S, Chroneos, ZC, Wang, M & Halstead, ES 2020, 'Lower respiratory tract delivery, airway clearance, and preclinical efficacy of inhaled GM-CSF in a postinfluenza pneumococcal pneumonia model', American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 318, no. 4, pp. L571-L579. https://doi.org/10.1152/AJPLUNG.00296.2019
2019
Simon, DW, Halstead, ES, Davila, S, Kernan, KF, Clark, RSB, Storch, G & Carcillo, JA 2019, 'DNA Viremia Is Associated with Hyperferritinemia in Pediatric Sepsis', Journal of Pediatrics, vol. 213, pp. 82-87.e2. https://doi.org/10.1016/j.jpeds.2019.06.033