Researcher Profile

Researcher Profile

Bryan Traughber, MD

Bryan Traughber, MD

Associate Professor and Vice Chair for Clinical Research, Department of Radiation Oncology
Scientific Program:Next-Generation Therapies
bft5163@psu.edu

Research Interests

Dr. Bryan Traughber has multiple patents and peer-reviewed manuscripts, as well as a track record of venture capital, research contracts and public funding for translational research, early-stage clinical trials and technology commercialization.

His research is multi-disciplinary and includes collaborations with cancer biologists, chemists, engineers, medical physicists and physicians to translate innovations to the clinic.

His expertise includes gynecologic, genitourinary and gastrointestinal oncology, HDR and LDR brachytherapy, MR-guided radiotherapy, drug delivery and molecular radiotherapy.

  • Therapeutics
  • Neoplasms
  • Radiotherapy
  • Brachytherapy
  • Prostate
  • Radiosurgery
  • Uterine Cervical Neoplasms
  • Magnetic Resonance Spectroscopy
  • Tomography
  • Multiparametric Magnetic Resonance Imaging
  • Bone and Bones
  • Urinary Bladder

Clinical Trials

Phase III Randomized Trial Of Concurrent Chemoradiotherapy With or Without Atezoluzumab in Localized Muscle Invasive Bladder Cancer
Phase 2 Study of Bladder-SparIng ChemoradiatioN with CIPosItive bladdeR cancEr (INSPIRE)EA8185
A Phase 3, Randomized, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Stereotactic Body Radiotherapy (SBRT) with or without Pembrolizumab (MK-3475) in Participants with Medically Inoperable Stages I or IIA Non Small Cell Lung Cancer (NSCLC)(KEYNOTE-867) MK 3475-867
NRG-HN005 - A Randomized Phase II/III Trial of De-intensified Radiation Therapy for Patients with Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer
Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer
Randomized Phase III Trial Incorporating Abiraterone Acetate with Prednisone and Apalutamide and Advanced Imaging Into Salvage Treatment for Patients with Node-Positive Prostate Cancer After Radical Prostatectomy
Phase III Study of PET-Directed Local or Systemic Therapy Intensification in Prostate Cancer Patients with Post-Prostatectomy Biochemical Recurrence
Parallel Phase III Randomized Trials for High Risk Prostate Cancer Evaluating De-Intensification for Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk with Radiation (PREDICT-RT*)
A Randomized, Phase 2 Study of Stereotactic Body Radiation Therapy (SBRT) in combination with GC4711 in the Treatment of Unresectable or Borderline Resectable, Nonmetastatic Pancreatic Cancer
Parallel Phase III Randomized Trials of Genomic-Risk Stratified Unfavorable Intermediate Risk Prostate Cancer: De-Intensification and Intensification Clinical Trial Evaluation (GUIDANCE)

Recent Publications

2022

Xu, ZZ, Traughber, BJ, Harris, E & Podder, TK 2022, 'Effect of applicator removal from target volume for cervical cancer patients treated with Venezia high-dose-rate brachytherapy applicator', Journal of Contemporary Brachytherapy, vol. 14, no. 2, pp. 176-182. https://doi.org/10.5114/jcb.2022.114929

2021

Baydoun, A, Xu, K, Bethell, LA, Zhou, F, Heo, JU, Zhao, K, Fredman, ET, Ellis, RJ, Qian, P, Muzic, RF & Traughber, B 2021, 'Auto-contouring FDG-PET/MR images for cervical cancer radiation therapy: An intelligent sequential approach using focally trained, shallow U-Nets', Intelligence-Based Medicine, vol. 5.
Liang, F, Traughber, BJ, Biswas, T, Guo, G, Muzic, RF & Podder, TK 2022, 'Coordinated control of a 3DOF cartesian robot and a shape memory alloy-actuated flexible needle for surgical interventions: A non-model-based control method', Robotica, vol. 40, no. 6, pp. 1695-1712. https://doi.org/10.1017/S0263574721001314
Agnes, RS, Traughber, B & Muzic, RF, Development of Imaging and Therapeutic Glucose Analogues for Sodium Dependent Glucose Transporters, Patent No. App. 17/062,018.
Muenkel, J, Xu, Z, Traughber, BJ, Baig, T, Xu, K, Langmack, C, Harris, E & Podder, TK 2021, 'Feasibility of improving patient's safety with in vivo dose tracking in intracavitary and interstitial HDR brachytherapy', Brachytherapy, vol. 20, no. 2, pp. 353-360. https://doi.org/10.1016/j.brachy.2020.09.010
Grubb, WR, Ponsky, L, Lo, SS, Kharouta, M, Traughber, B, Sandstrom, K, MacLennan, GT, Shankar, E, Gupta, S, Machtay, M & Ellis, RJ 2021, 'Final results of a dose escalation protocol of stereotactic body radiotherapy for poor surgical candidates with localized renal cell carcinoma', Radiotherapy and Oncology, vol. 155, pp. 138-143. https://doi.org/10.1016/j.radonc.2020.10.031
Fredman, E, Traughber, B, Kharouta, M, Podder, T, Lo, S, Ponsky, L, MacLennan, G, Paspulati, R, Ellis, B, Machtay, M & Ellis, R 2021, 'Focal Prostate Stereotactic Body Radiation Therapy With Correlative Pathological and Radiographic-Based Treatment Planning', Frontiers in Oncology, vol. 11, 744130. https://doi.org/10.3389/fonc.2021.744130
Baydoun, A, Xu, K, Heo, JU, Yang, H, Zhou, F, Bethell, LA, Fredman, ET, Ellis, RJ, Podder, TK, Traughber, MS, Paspulati, RM, Qian, P, Traughber, BJ & Muzic, RF 2021, 'Synthetic CT Generation of the Pelvis in Patients with Cervical Cancer: A Single Input Approach Using Generative Adversarial Network', IEEE Access, vol. 9, 9316666, pp. 17208-17221. https://doi.org/10.1109/ACCESS.2021.3049781
Qian, P, Zheng, J, Zheng, Q, Liu, Y, Wang, T, Al Helo, R, Baydoun, A, Avril, N, Ellis, RJ, Friel, H, Traughber, MS, Devaraj, A, Traughber, B & Muzic, RF 2021, 'Transforming UTE-mDixon MR Abdomen-Pelvis Images into CT by Jointly Leveraging Prior Knowledge and Partial Supervision', IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 18, no. 1, 9034480, pp. 70-82. https://doi.org/10.1109/TCBB.2020.2979841

2020

Nakayama, J, El-Nashar, SA, Waggoner, S, Traughber, B & Kesterson, J 2020, 'Adjusting to the new reality: Evaluation of early practice pattern adaptations to the COVID-19 pandemic', Gynecologic Oncology, vol. 158, no. 2, pp. 256-261. https://doi.org/10.1016/j.ygyno.2020.05.028
Baydoun, A, Xu, K, Yang, H, Zhou, F, Heo, JU, Jones, RS, Avril, N, Traughber, M, Traughber, BJ, Qian, P & Muzic, RF 2020, 'Dixon-based thorax synthetic CT generation using Generative Adversarial Network', Intelligence-Based Medicine, vol. 3-4, 100010. https://doi.org/10.1016/j.ibmed.2020.100010
Podder, TK, Dey, A, Datta, S, Traughber, B, Russo, S & Biswas, T 2020, 'EBRT Modality-Specific Treatment Outcome of Cervical Cancer Patients for Real-World Practice', Open Access Journal of Cancer & Oncology, vol. 4, no. 2. https://doi.org/10.23880/oajco-16000162
Qian, P, Xu, K, Wang, T, Zheng, Q, Yang, H, Baydoun, A, Zhu, J, Traughber, B & Muzic, RF 2020, 'Estimating CT from MR Abdominal Images Using Novel Generative Adversarial Networks', Journal of Grid Computing, vol. 18, no. 2, pp. 211-226. https://doi.org/10.1007/s10723-020-09513-3
Qian, P, Chen, Y, Kuo, JW, Zhang, YD, Jiang, Y, Zhao, K, Al Helo, R, Friel, H, Baydoun, A, Zhou, F, Heo, JU, Avril, N, Herrmann, K, Ellis, R, Traughber, B, Jones, RS, Wang, S, Su, KH & Muzic, RF 2020, 'MDixon-Based Synthetic CT Generation for PET Attenuation Correction on Abdomen and Pelvis Jointly Using Transfer Fuzzy Clustering and Active Learning-Based Classification', IEEE transactions on medical imaging, vol. 39, no. 4, 8804223, pp. 819-832. https://doi.org/10.1109/TMI.2019.2935916
Song, X, Qian, P, Zheng, J, Jiang, Y, Xia, K, Traughber, B, Wu, D & Muzic, RF 2020, 'mDixon-based synthetic CT generation via transfer and patch learning', Pattern Recognition Letters, vol. 138, pp. 51-59. https://doi.org/10.1016/j.patrec.2020.06.017

2019

Xu, Z, Traughber, BJ, Fredman, E, Albani, D, Ellis, RJ & Podder, TK 2019, 'Appropriate Methodology for EBRT and HDR Intracavitary/Interstitial Brachytherapy Dose Composite and Clinical Plan Evaluation for Patients With Cervical Cancer', Practical Radiation Oncology, vol. 9, no. 6, pp. e559-e571. https://doi.org/10.1016/j.prro.2019.06.003
Fredman, ET, Traughber, BJ, Gross, A, Podder, T, Colussi, V, Vinkler, R, Machtay, M & Ellis, RJ 2019, 'Comparison of multiparametric MRI-based and transrectal ultrasound-based preplans with intraoperative ultrasound-based planning for low dose rate interstitial prostate seed implantation', Journal of applied clinical medical physics, vol. 20, no. 6, pp. 31-38. https://doi.org/10.1002/acm2.12592
Su, KH, Friel, HT, Kuo, JW, Al Helo, R, Baydoun, A, Stehning, C, Crisan, AN, Traughber, MS, Devaraj, A, Jordan, DW, Qian, P, Leisser, A, Ellis, RJ, Herrmann, KA, Avril, N, Traughber, BJ & Muzic, RF 2019, 'UTE-mDixon-based thorax synthetic CT generation', Medical Physics, vol. 46, no. 8, pp. 3520-3531. https://doi.org/10.1002/mp.13574

2018

Fredman, E, Traughber, B, Podder, T, Colussi, V, Zheng, Y, Russo, S, Herrmann, K, Paspulati, R, Waggoner, S, Zanotti, K, Nagel, C, Nakayama, J, Machtay, M & Ellis, RJ 2018, '3T multiparametric MRI–guided high-dose-rate combined intracavitary and interstitial adaptive brachytherapy for the treatment of cervical cancer with a novel split-ring applicator', Brachytherapy, vol. 17, no. 2, pp. 334-344. https://doi.org/10.1016/j.brachy.2017.09.007
Liang, F, Qian, P, Su, KH, Baydoun, A, Leisser, A, Van Hedent, S, Kuo, JW, Zhao, K, Parikh, P, Lu, Y, Traughber, BJ & Muzic, RF 2018, 'Abdominal, multi-organ, auto-contouring method for online adaptive magnetic resonance guided radiotherapy: An intelligent, multi-level fusion approach', Artificial Intelligence in Medicine, vol. 90, pp. 34-41. https://doi.org/10.1016/j.artmed.2018.07.001
Baydoun, A, Vapiwala, N, Ponsky, LE, Awan, M, Kassaee, A, Sutton, D, Podder, TK, Zhang, Y, Dobbins, D, Muzic, RF, Traughber, B, Machtay, M & Ellis, R 2018, 'Comparative analysis for renal stereotactic body radiotherapy using Cyberknife, VMAT and proton therapy based treatment planning', Journal of applied clinical medical physics, vol. 19, no. 3, pp. 125-130. https://doi.org/10.1002/acm2.12308
Su, KH, Kuo, JW, Jordan, DW, Van Hedent, S, Klahr, P, Wei, Z, Al Helo, R, Liang, F, Qian, P, Pereira, GC, Rassouli, N, Gilkeson, RC, Traughber, BJ, Cheng, CW & Muzic, RF 2018, 'Machine learning-based dual-energy CT parametric mapping', Physics in Medicine and Biology, vol. 63, no. 12, 125001. https://doi.org/10.1088/1361-6560/aac711
Warrell, GR, Xing, Y, Podder, TK, Traughber, BJ & Ellis, RJ 2018, 'Reduction of seed motion using a bio-absorbable polymer coating during permanent prostate brachytherapy using a mick applicator technique', Journal of applied clinical medical physics, vol. 19, no. 3, pp. 44-51. https://doi.org/10.1002/acm2.12254

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)