Researcher Profile

Researcher Profile

Rodney J. Ellis, MD

Rodney J. Ellis, MD

Professor and Chair, Department of Radiation Oncology
Scientific Program:Next-Generation Therapies
Disease Teams:
Genitourinary Cancer
rje5240@psu.edu

Research Interests

Dr. Rodney Ellis' primary research interest is in molecular imaging for prostate cancer and radiation therapy planning for advanced image-guided radiation applications. He is the principal investigator for a Phase III randomized trial for intermediate-risk men with prostate cancer, randomized between hyperfractionated radiation and stereotactic radiosurgery. His main focus of research and expertise is in advanced image guidance for dose-painting prostate cancer, utilizing either IMRT/SBRT or brachytherapy with multimodality imaging.

  • Therapeutics
  • Radiotherapy
  • Prostate
  • Radiosurgery
  • Brachytherapy
  • Neoplasms
  • Prostatic Neoplasms
  • Renal Cell Carcinoma
  • Tomography
  • Kidney
  • Capromab Pendetide
  • Survival

Clinical Trials

Phase III Randomized Trial Of Concurrent Chemoradiotherapy With or Without Atezoluzumab in Localized Muscle Invasive Bladder Cancer
Phase 2 Study of Bladder-SparIng ChemoradiatioN with CIPosItive bladdeR cancEr (INSPIRE)EA8185
NRG-GU005 Phase III IGRT and SBRT VS IGRT and hypofractionated IMRT for localized intermediate risk prostate cancer
NRG-HN005 - A Randomized Phase II/III Trial of De-intensified Radiation Therapy for Patients with Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer
NCI COVID-19 in Cancer Patients Study (N-CCaPS): A Longitudinal Natural History Study
Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer
Phase III Study of PET-Directed Local or Systemic Therapy Intensification in Prostate Cancer Patients with Post-Prostatectomy Biochemical Recurrence
A Randomized Phase II Trial of Salvage Radiotherapy with Standard vs Enhanced Androgen Deprivation Therapy (with Enzalutamide) in Patients with Post-Prostatectomy PSA Recurrences with Aggressive Disease Features RTOG 3506, STEEL

Recent Publications

2021

Baydoun, A, Xu, K, Bethell, LA, Zhou, F, Heo, JU, Zhao, K, Fredman, ET, Ellis, RJ, Qian, P, Muzic, RF & Traughber, B 2021, 'Auto-contouring FDG-PET/MR images for cervical cancer radiation therapy: An intelligent sequential approach using focally trained, shallow U-Nets', Intelligence-Based Medicine, vol. 5.
Grubb, WR, Ponsky, L, Lo, SS, Kharouta, M, Traughber, B, Sandstrom, K, MacLennan, GT, Shankar, E, Gupta, S, Machtay, M & Ellis, RJ 2021, 'Final results of a dose escalation protocol of stereotactic body radiotherapy for poor surgical candidates with localized renal cell carcinoma', Radiotherapy and Oncology, vol. 155, pp. 138-143. https://doi.org/10.1016/j.radonc.2020.10.031
Fredman, E, Traughber, B, Kharouta, M, Podder, T, Lo, S, Ponsky, L, MacLennan, G, Paspulati, R, Ellis, B, Machtay, M & Ellis, R 2021, 'Focal Prostate Stereotactic Body Radiation Therapy With Correlative Pathological and Radiographic-Based Treatment Planning', Frontiers in Oncology, vol. 11, 744130. https://doi.org/10.3389/fonc.2021.744130
Baydoun, A, Xu, K, Heo, JU, Yang, H, Zhou, F, Bethell, LA, Fredman, ET, Ellis, RJ, Podder, TK, Traughber, MS, Paspulati, RM, Qian, P, Traughber, BJ & Muzic, RF 2021, 'Synthetic CT Generation of the Pelvis in Patients with Cervical Cancer: A Single Input Approach Using Generative Adversarial Network', IEEE Access, vol. 9, 9316666, pp. 17208-17221. https://doi.org/10.1109/ACCESS.2021.3049781
Qian, P, Zheng, J, Zheng, Q, Liu, Y, Wang, T, Al Helo, R, Baydoun, A, Avril, N, Ellis, RJ, Friel, H, Traughber, MS, Devaraj, A, Traughber, B & Muzic, RF 2021, 'Transforming UTE-mDixon MR Abdomen-Pelvis Images into CT by Jointly Leveraging Prior Knowledge and Partial Supervision', IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 18, no. 1, 9034480, pp. 70-82. https://doi.org/10.1109/TCBB.2020.2979841

2020

Qian, P, Chen, Y, Kuo, JW, Zhang, YD, Jiang, Y, Zhao, K, Al Helo, R, Friel, H, Baydoun, A, Zhou, F, Heo, JU, Avril, N, Herrmann, K, Ellis, R, Traughber, B, Jones, RS, Wang, S, Su, KH & Muzic, RF 2020, 'MDixon-Based Synthetic CT Generation for PET Attenuation Correction on Abdomen and Pelvis Jointly Using Transfer Fuzzy Clustering and Active Learning-Based Classification', IEEE transactions on medical imaging, vol. 39, no. 4, 8804223, pp. 819-832. https://doi.org/10.1109/TMI.2019.2935916
Tchelebi, LT, Zaorsky, NG, Rosenberg, JC, Sharma, NK, Tuanquin, LC, MacKley, HB & Ellis, RJ 2020, 'Reducing the Toxicity of Radiotherapy for Pancreatic Cancer with Magnetic Resonance-guided Radiotherapy', Toxicological Sciences, vol. 175, no. 1, pp. 19-23. https://doi.org/10.1093/toxsci/kfaa021
Duffy, SR, Zheng, Y, Muenkel, J, Ellis, RJ, Baig, TN, Krancevic, B, Langmack, CB, Kelley, KD & Choi, S 2020, 'Refining complex re-irradiation dosimetry through feasibility benchmarking and analysis for informed treatment planning', Journal of applied clinical medical physics, vol. 21, no. 12, pp. 263-271. https://doi.org/10.1002/acm2.13102
Correa, RJM, Louie, AV, Zaorsky, NG, Lehrer, EJ, Ellis, R, Ponsky, L, Kaplan, I, Mahadevan, A, Chu, W, Swaminath, A, Hannan, R, Onishi, H, Teh, BS, Muacevic, A, Lo, SS, Staehler, M & Siva, S 2021, 'Reply to Francesco Montorsi, Alessandro Larcher, and Umberto Capitanio's Letter to the Editor re: Rohann J.M. Correa, Alexander V. Louie, Nicholas G. Zaorsky, et al. The Emerging Role of Stereotactic Ablative Radiotherapy for Primary Renal Cell Carcinoma: A Systematic Review and Meta-Analysis. Eur Urol Focus. 2019 Jun 24. pii: S2405-4569(19)30157-9. https://doi.org/10.1016/j.euf.2019.06.002. [Epub ahead of print]', European Urology Focus, vol. 7, no. 2, pp. 404-405. https://doi.org/10.1016/j.euf.2019.10.004
Siva, S, Correa, RJM, Warner, A, Staehler, M, Ellis, RJ, Ponsky, L, Kaplan, ID, Mahadevan, A, Chu, W, Gandhidasan, S, Swaminath, A, Onishi, H, Teh, BS, Lo, SS, Muacevic, A & Louie, AV 2020, 'Stereotactic Ablative Radiotherapy for ≥T1b Primary Renal Cell Carcinoma: A Report From the International Radiosurgery Oncology Consortium for Kidney (IROCK)', International Journal of Radiation Oncology Biology Physics, vol. 108, no. 4, pp. 941-949. https://doi.org/10.1016/j.ijrobp.2020.06.014
Lehrer, EJ, Kishan, AU, Yu, JB, Trifiletti, DM, Showalter, TN, Ellis, R & Zaorsky, NG 2020, 'Ultrahypofractionated versus hypofractionated and conventionally fractionated radiation therapy for localized prostate cancer: A systematic review and meta-analysis of phase III randomized trials', Radiotherapy and Oncology, vol. 148, pp. 235-242. https://doi.org/10.1016/j.radonc.2020.04.037
Quinn, TJ, Daignault-Newton, S, Bosch, W, Mariados, N, Sylvester, J, Shah, D, Gross, E, Hudes, R, Beyer, D, Kurtzman, S, Bogart, J, Hsi, RA, Kos, M, Ellis, R, Logsdon, M, Zimberg, S, Forsythe, K, Zhang, H, Soffen, E, Francke, P, Mantz, C, DeWeese, T, Gay, HA, Michalski, J & Hamstra, DA 2020, 'Who Benefits From a Prostate Rectal Spacer? Secondary Analysis of a Phase III Trial', Practical Radiation Oncology, vol. 10, no. 3, pp. 186-194. https://doi.org/10.1016/j.prro.2019.12.011

2019

Xu, Z, Traughber, BJ, Fredman, E, Albani, D, Ellis, RJ & Podder, TK 2019, 'Appropriate Methodology for EBRT and HDR Intracavitary/Interstitial Brachytherapy Dose Composite and Clinical Plan Evaluation for Patients With Cervical Cancer', Practical Radiation Oncology, vol. 9, no. 6, pp. e559-e571. https://doi.org/10.1016/j.prro.2019.06.003
Xu, Z, Warrell, G, Lee, S, Colussi, V, Zheng, Y, Ellis, RJ, Machtay, M & Podder, T 2019, 'Assessment of beam-matched linacs quality/accuracy for interchanging SBRT or SRT patient using VMAT without replanning', Journal of applied clinical medical physics, vol. 20, no. 1, pp. 68-75. https://doi.org/10.1002/acm2.12492
Fredman, ET, Traughber, BJ, Gross, A, Podder, T, Colussi, V, Vinkler, R, Machtay, M & Ellis, RJ 2019, 'Comparison of multiparametric MRI-based and transrectal ultrasound-based preplans with intraoperative ultrasound-based planning for low dose rate interstitial prostate seed implantation', Journal of applied clinical medical physics, vol. 20, no. 6, pp. 31-38. https://doi.org/10.1002/acm2.12592
Xu, Z, Lee, S, Albani, D, Dobbins, D, Ellis, RJ, Biswas, T, Machtay, M & Podder, TK 2019, 'Evaluating radiotherapy treatment delay using Failure Mode and Effects Analysis (FMEA)', Radiotherapy and Oncology, vol. 137, pp. 102-109. https://doi.org/10.1016/j.radonc.2019.04.016
Hsiao, CP, Chen, MK, Veigl, ML, Ellis, R, Cooney, M, Daly, B & Hoppel, C 2019, 'Relationships between expression of BCS1L, mitochondrial bioenergetics, and fatigue among patients with prostate cancer', Cancer Management and Research, vol. 11, pp. 6703-6717. https://doi.org/10.2147/CMAR.S203317
Correa, RJM, Louie, AV, Staehler, M, Warner, A, Gandhidasan, S, Ponsky, L, Ellis, R, Kaplan, I, Mahadevan, A, Chu, W, Swaminath, A, Onishi, H, Teh, BS, Lo, SS, Muacevic, A & Siva, S 2019, 'Stereotactic Radiotherapy as a Treatment Option for Renal Tumors in the Solitary Kidney: A Multicenter Analysis from the IROCK', Journal of Urology, vol. 201, no. 6, pp. 1097-1103. https://doi.org/10.1097/JU.0000000000000111
Correa, RJM, Louie, AV, Zaorsky, NG, Lehrer, EJ, Ellis, R, Ponsky, L, Kaplan, I, Mahadevan, A, Chu, W, Swaminath, A, Hannan, R, Onishi, H, Teh, BS, Muacevic, A, Lo, SS, Staehler, M & Siva, S 2019, 'The Emerging Role of Stereotactic Ablative Radiotherapy for Primary Renal Cell Carcinoma: A Systematic Review and Meta-Analysis', European Urology Focus, vol. 5, no. 6, pp. 958-969. https://doi.org/10.1016/j.euf.2019.06.002
Su, KH, Friel, HT, Kuo, JW, Al Helo, R, Baydoun, A, Stehning, C, Crisan, AN, Traughber, MS, Devaraj, A, Jordan, DW, Qian, P, Leisser, A, Ellis, RJ, Herrmann, KA, Avril, N, Traughber, BJ & Muzic, RF 2019, 'UTE-mDixon-based thorax synthetic CT generation', Medical Physics, vol. 46, no. 8, pp. 3520-3531. https://doi.org/10.1002/mp.13574

2018

Fredman, E, Traughber, B, Podder, T, Colussi, V, Zheng, Y, Russo, S, Herrmann, K, Paspulati, R, Waggoner, S, Zanotti, K, Nagel, C, Nakayama, J, Machtay, M & Ellis, RJ 2018, '3T multiparametric MRI–guided high-dose-rate combined intracavitary and interstitial adaptive brachytherapy for the treatment of cervical cancer with a novel split-ring applicator', Brachytherapy, vol. 17, no. 2, pp. 334-344. https://doi.org/10.1016/j.brachy.2017.09.007
Podder, TK, Fredman, ET & Ellis, RJ 2018, Advances in radiotherapy for prostate cancer treatment. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1126, Springer New York LLC, pp. 31-47. https://doi.org/10.1007/978-3-319-99286-0_2
Baydoun, A, Vapiwala, N, Ponsky, LE, Awan, M, Kassaee, A, Sutton, D, Podder, TK, Zhang, Y, Dobbins, D, Muzic, RF, Traughber, B, Machtay, M & Ellis, R 2018, 'Comparative analysis for renal stereotactic body radiotherapy using Cyberknife, VMAT and proton therapy based treatment planning', Journal of applied clinical medical physics, vol. 19, no. 3, pp. 125-130. https://doi.org/10.1002/acm2.12308
Dorth, JA, Lee, WR, Chino, J, Abouassaly, R, Ellis, RJ & Myers, ER 2018, 'Cost-Effectiveness of Primary Radiation Therapy Versus Radical Prostatectomy for Intermediate- to High-Risk Prostate Cancer', International Journal of Radiation Oncology Biology Physics, vol. 100, no. 2, pp. 383-390. https://doi.org/10.1016/j.ijrobp.2017.10.024
Scarberry, K, Ponsky, L, Cherullo, E, Larchian, W, Bodner, D, Cooney, M, Ellis, R, MacLennan, G, Johnson, B, Tabayoyong, W & Abouassaly, R 2018, 'Evaluating the impact of the genitourinary multidisciplinary tumour board: Should every cancer patient be discussed as standard of care?', Canadian Urological Association Journal, vol. 12, no. 9, pp. E403-E408. https://doi.org/10.5489/cuaj.5150
Siva, S, Louie, AV, Warner, A, Muacevic, A, Gandhidasan, S, Ponsky, L, Ellis, R, Kaplan, I, Mahadevan, A, Chu, W, Swaminath, A, Onishi, H, Teh, B, Correa, RJ, Lo, SS & Staehler, M 2018, 'Pooled analysis of stereotactic ablative radiotherapy for primary renal cell carcinoma: A report from the International Radiosurgery Oncology Consortium for Kidney (IROCK)', Cancer, vol. 124, no. 5, pp. 934-942. https://doi.org/10.1002/cncr.31156
Lo, SS, Biswas, T, Ellis, RJ & Gerszten, PC 2018, Radiosurgery. in Essentials of Interventional Cancer Pain Management. Springer International Publishing, pp. 235-240. https://doi.org/10.1007/978-3-319-99684-4_24
Warrell, GR, Xing, Y, Podder, TK, Traughber, BJ & Ellis, RJ 2018, 'Reduction of seed motion using a bio-absorbable polymer coating during permanent prostate brachytherapy using a mick applicator technique', Journal of applied clinical medical physics, vol. 19, no. 3, pp. 44-51. https://doi.org/10.1002/acm2.12254
Hamstra, DA, Mariados, N, Sylvester, J, Shah, D, Gross, E, Hudes, R, Beyer, D, Kurtzman, S, Bogart, J, Hsi, RA, Kos, M, Ellis, R, Logsdon, M, Zimberg, S, Forsythe, K, Zhang, H, Soffen, E, Francke, P, Mantz, C, Rossi, P, DeWeese, T, Daignault-Newton, S, Fischer-Valuck, BW, Chundury, A, Gay, HA, Bosch, W & Michalski, J 2018, 'Sexual quality of life following prostate intensity modulated radiation therapy (IMRT) with a rectal/prostate spacer: Secondary analysis of a phase 3 trial', Practical Radiation Oncology, vol. 8, no. 1, pp. e7-e15. https://doi.org/10.1016/j.prro.2017.07.008
Yuan, J, Ellis, R & Machtay, M 2018, 'Technical Note: An approach to building a Monte Carlo simulation model for a double scattering proton beam system', Medical Physics, vol. 45, no. 6, pp. 2660-2666. https://doi.org/10.1002/mp.12895

2017

Spencer, K, Ellis, R, Birch, R, Dugdale, E, Turner, R, Sebag-Montefiore, D, Hall, G, Crellin, A & Morris, E 2017, 'Caution is required in the implementation of 90-day mortality indicators for radiotherapy in a curative setting: A retrospective population-based analysis of over 16,000 episodes', Radiotherapy and Oncology, vol. 125, no. 1, pp. 140-146. https://doi.org/10.1016/j.radonc.2017.07.031
Hamstra, DA, Mariados, N, Sylvester, J, Shah, D, Karsh, L, Hudes, R, Beyer, D, Kurtzman, S, Bogart, J, Hsi, RA, Kos, M, Ellis, R, Logsdon, M, Zimberg, S, Forsythe, K, Zhang, H, Soffen, E, Francke, P, Mantz, C, Rossi, P, DeWeese, T, Daignault-Newton, S, Fischer-Valuck, BW, Chundury, A, Gay, H, Bosch, W & Michalski, J 2017, 'Continued Benefit to Rectal Separation for Prostate Radiation Therapy: Final Results of a Phase III Trial', International Journal of Radiation Oncology Biology Physics, vol. 97, no. 5, pp. 976-985. https://doi.org/10.1016/j.ijrobp.2016.12.024
Lee, S, Ellis, RJ, Traughber, B, Biswas, T, Colussi, V & Podder, T 2017, 'Evaluation of interfractional variation of organs and displacement of catheters during high-dose-rate interstitial brachytherapy for gynecologic malignancies', Brachytherapy, vol. 16, no. 6, pp. 1192-1198. https://doi.org/10.1016/j.brachy.2017.09.001
Baydoun, A, Traughber, B, Morris, N, Abi Zeid Daou, M, McGraw, M, Podder, TK, Muzic, RF, Lo, SS, Ponsky, LE, MacHtay, M & Ellis, R 2017, 'Outcomes and toxicities in patients treated with definitive focal therapy for primary prostate cancer: Systematic review', Future Oncology, vol. 13, no. 7, pp. 649-663. https://doi.org/10.2217/fon-2016-0354
Liang, F, Traughber, B, Musiz, R, Ellis, R & Podder, T 2017, Reconstruction of brachytherapy catheters and needles using em sensor-based navigation system. in Frontiers in Biomedical Devices, BIOMED - 2017 Design of Medical Devices Conference, DMD 2017. Frontiers in Biomedical Devices, BIOMED - 2017 Design of Medical Devices Conference, DMD 2017, American Society of Mechanical Engineers, Frontiers in Biomedical Devices, BIOMED - 2017 Design of Medical Devices Conference, DMD 2017, Minneapolis, United States, 4/10/17. https://doi.org/10.1115/DMD2017-3536

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)