Researcher Profile

Researcher Profile

Seyed Alireza Mansouri, MD

Seyed Alireza Mansouri, MD

Assistant Professor, Department of Neurosurgery
Scientific Program:Next-Generation Therapies

Research Interests

  • Systematic Reviews
  • Meta-Analysis
  • Therapeutics
  • Meningioma
  • Neoplasms
  • Glioma
  • Seizures
  • Radiosurgery
  • Epilepsy
  • Confidence Intervals
  • Data Analysis
  • Morbidity

Recent Publications


Ye, VC, Mansouri, A, Warsi, NM & Ibrahim, GM 2020, 'Atonic seizures in children: a meta-analysis comparing corpus callosotomy to vagus nerve stimulation', Child's Nervous System.
Mansouri, A, Boutet, A, Elias, G, Germann, J, Yan, H, Babu, H, Lozano, AM & Valiante, TA 2020, 'Lesion Network Mapping Analysis Identifies Potential Cause of Postoperative Depression in a Case of Cingulate Low-Grade Glioma', World neurosurgery, vol. 133, pp. 278-282.
Remick, M, Ibrahim, GM, Mansouri, A & Abel, TJ 2020, 'Patient phenotypes and clinical outcomes in invasive monitoring for epilepsy: An individual patient data meta-analysis', Epilepsy and Behavior, vol. 102, 106652.
Daggubati, LC, Eichberg, DG, Ivan, ME, Hanft, S, Mansouri, A, Komotar, RJ, D'Amico, RS & Zacharia, BE 2020, 'Telemedicine for Outpatient Neurosurgical Oncology Care: Lessons Learned for the Future During the COVID-19 Pandemic', World neurosurgery.


International Consortium on Meningiomas 2019, 'Advances in multidisciplinary therapy for meningiomas', Neuro-oncology, vol. 21, pp. I18-I31.
Koziarz, A, Sne, N, Kegel, F, Nath, S, Badhiwala, JH, Nassiri, F, Mansouri, A, Yang, K, Zhou, Q, Rice, T, Faidi, S, Passos, E, Healey, A, Banfield, L, Mensour, M, Kirkpatrick, AW, Nassar, A, Fehlings, MG, Hawryluk, GWJ & Almenawer, SA 2019, 'Bedside optic nerve ultrasonography for diagnosing increased intracranial pressure', Annals of internal medicine, vol. 171, no. 12, pp. 896-905.
Harmsen, IE, Elias, GJB, Beyn, ME, Boutet, A, Pancholi, A, Germann, J, Mansouri, A, Lozano, CS & Lozano, AM 2020, 'Clinical trials for deep brain stimulation: Current state of affairs', Brain Stimulation, vol. 13, no. 2, pp. 378-385.
Badhiwala, JH, Witiw, CD, Nassiri, F, Akbar, MA, Mansouri, A, Wilson, JR & Fehlings, MG 2019, 'Efficacy and safety of surgery for mild degenerative cervical myelopathy: results of the aospine North America and international prospective multicenter studies', Clinical Neurosurgery, vol. 84, no. 4, pp. 890-897.
International Consortium on Meningiomas 2019, 'Imaging and diagnostic advances for intracranial meningiomas', Neuro-oncology, vol. 21, pp. I44-I61.
Badhiwala, JH, Nassiri, F, Witiw, CD, Mansouri, SA, Almenawer, SA, Da Costa, L, Fehlings, MG & Wilson, JR 2019, 'Investigating the utility of intraoperative neurophysiological monitoring for anterior cervical discectomy and fusion: Analysis of over 140,000 cases from the National (Nationwide) Inpatient Sample data set', Journal of Neurosurgery: Spine, vol. 31, no. 1, pp. 76-86.
Agnihotri, S, Mansouri, S, Burrell, K, Li, M, Mamatjan, Y, Liu, J, Nejad, R, Kumar, S, Jalali, S, Singh, SK, Vartanian, A, Chen, EX, Karimi, S, Singh, O, Bunda, S, Mansouri, A, Aldape, KD & Zadeh, G 2019, 'Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells', Clinical Cancer Research, vol. 25, no. 2, pp. 844-855.
International Consortium on Meningiomas 2019, 'Life after surgical resection of a meningioma: A prospective cross-sectional study evaluating health-related quality of life', Neuro-oncology, vol. 21, pp. I32-I43.
Philteos, J, Karmur, BS & Mansouri, A 2019, 'MGMT Testing in Glioblastomas', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 42, no. 2, pp. 117-122.
Mansouri, A, Hachem, LD, Mansouri, S, Nassiri, F, Laperriere, NJ, Xia, D, Lindeman, NI, Wen, PY, Chakravarti, A, Mehta, MP, Hegi, ME, Stupp, R, Aldape, KD & Zadeh, G 2019, 'MGMT promoter methylation status testing to guide therapy for glioblastoma: Refining the approach based on emerging evidence and current challenges', Neuro-oncology, vol. 21, no. 2, pp. 167-178.
Yan, H, Katz, JS, Anderson, M, Mansouri, SA, Remick, M, Ibrahim, GM & Abel, TJ 2019, 'Method of invasive monitoring in epilepsy surgery and seizure freedom and morbidity: A systematic review', Epilepsia, vol. 60, no. 9, pp. 1960-1972.
International Consortium on Meningiomas 2019, 'Molecular and translational advances in meningiomas', Neuro-oncology, vol. 21, pp. I4-I17.
Taslimi, S, Zuccato, JA, Mansouri, A, Hachem, LD, Badhiwala, J, Kuchta, J, Chen, J & Pirouzmand, F 2019, 'Novel Statistical Analyses to Assess Hearing Outcomes After ABI Implantation in NF2 Patients: Systematic Review and Individualized Patient Data Analysis', World neurosurgery, vol. 128, pp. e669-e682.
Almeida, JP, Sanchez, MM, Karekezi, C, Warsi, N, Fernández-Gajardo, R, Panwar, J, Mansouri, A, Suppiah, S, Nassiri, F, Nejad, R, Kucharczyk, W, Ridout, R, Joaquim, AF, Gentili, F & Zadeh, G 2019, 'Pituitary Apoplexy: Results of Surgical and Conservative Management Clinical Series and Review of the Literature', World neurosurgery, vol. 130, pp. e988-e999.
Glicksman, RM, Tjong, MC, Neves-Junior, WFP, Spratt, DE, Chua, KLM, Mansouri, A, Chua, MLK, Berlin, A, Winter, JD, Dahele, M, Slotman, BJ, Bilsky, M, Shultz, DB, Maldaun, M, Szerlip, N, Lo, SS, Yamada, Y, Vera-Badillo, FE, Marta, GN & Moraes, FY 2019, 'Stereotactic Ablative Radiotherapy for the Management of Spinal Metastases: A Review', JAMA Oncology.
Mansouri, A, Taslimi, S, Abbasian, A, Badhiwala, JH, Akbar, MA, Alotaibi, NM, Almenawer, SA, Weil, AG, Fallah, A, Carmant, L & Ibrahim, GM 2019, 'Surgical outcomes for medically intractable epilepsy in low- and middle-income countries: A systematic review and meta-analysis', Journal of neurosurgery, vol. 131, no. 4, pp. 1068-1078.


He, J, Mansouri, A & Das, S 2018, 'Alpha thalassemia/mental retardation syndrome X-linked, the alternative lengthening of telomere phenotype, and gliomagenesis: Current understandings and future potential', Frontiers in Oncology, vol. 7, no. JAN, 322.
Hachem, LD, Mansouri, A, Scales, DC, Geerts, W & Pirouzmand, F 2018, 'Anticoagulant prophylaxis against venous thromboembolism following severe traumatic brain injury: A prospective observational study and systematic review of the literature', Clinical Neurology and Neurosurgery, vol. 175, pp. 68-73.
Yang, K, Nath, S, Koziarz, A, Badhiwala, JH, Ghayur, H, Sourour, M, Catana, D, Nassiri, F, Alotaibi, MB, Kameda-Smith, M, Manoranjan, B, Aref, MH, Mansouri, SA, Singh, S & Almenawer, SA 2018, 'Biopsy Versus Subtotal Versus Gross Total Resection in Patients with Low-Grade Glioma: A Systematic Review and Meta-Analysis', World neurosurgery, vol. 120, pp. e762-e775.
Samuel, N, Philteos, J, Alotaibi, NM, Ahuja, C, Mansouri, A & Kulkarni, AV 2018, 'Canadian Neurosurgery Educators’ Views on Stereotactic Radiosurgery in Residency Training', World neurosurgery, vol. 112, pp. e208-e215.
Mansouri, SA, Taslimi, S, Badhiwala, JH, Witiw, CD, Nassiri, F, Odekerken, VJJ, De Bie, RMA, Kalia, SK, Hodaie, M, Munhoz, RP, Fasano, A & Lozano, AM 2018, 'Deep brain stimulation for Parkinson's disease: Meta-analysis of results of randomized trials at varying lengths of follow-up', Journal of neurosurgery, vol. 128, no. 4, pp. 1199-1213.
Klironomos, G, Gonen, L, Au, K, Monteiro, E, Mansouri, SA, Turel, MK, Witterick, I, Vescan, A, Zadeh, G & Gentili, F 2018, 'Endoscopic management of Esthesioneuroblastoma: Our experience and review of the literature', Journal of Clinical Neuroscience, vol. 58, pp. 117-123.
Mansouri, A, Ku, JC, Khu, KJ, Mahmud, MR, Sedney, C, Ammar, A, Godoy, BL, Abbasian, A & Bernstein, M 2018, 'Exploratory Analysis into Reasonable Timeframes for the Provision of Neurosurgical Care in Low- and Middle-Income Countries', World neurosurgery, vol. 117, pp. e679-e691.
Witiw, CD, Mansouri, A, Mathieu, F, Nassiri, F, Badhiwala, JH & Fessler, RG 2018, 'Exploring the expectation-actuality discrepancy: a systematic review of the impact of preoperative expectations on satisfaction and patient reported outcomes in spinal surgery', Neurosurgical Review, vol. 41, no. 1, pp. 19-30.
Hachem, LD, Mansouri, A, Chen, J & Pirouzmand, F 2018, 'Feasibility of real-time intraoperative fluorescence imaging of dural sinus thrombosis', Journal of Clinical Neuroscience, vol. 52, pp. 153-155.
Badhiwala, JH, Nassiri, F, Witiw, CD, Mansouri, A, Alotaibi, N, Eagles, M, Almenawer, SA, Da Costa, L, Wilson, JR & Fehlings, MG 2018, 'Highly cited works in spinal disorders: The top 100 most cited papers published in spine journals', Spine, vol. 43, no. 24, pp. 1746-1755.
Mansouri, SA, Moraes, FY & Zadeh, G 2018, 'Nivolumab and ipilimumab in melanoma metastatic to the brain', New England Journal of Medicine, vol. 379, no. 22, pp. 2177-2178.
Badhiwala, JH, Witiw, CD, Nassiri, F, Jaja, BNR, Akbar, MA, Mansouri, SA, Merali, Z, Ibrahim, GM, Wilson, JR & Fehlings, MG 2018, 'Patient phenotypes associated with outcome following surgery for mild degenerative cervical myelopathy: a principal component regression analysis', Spine Journal, vol. 18, no. 12, pp. 2220-2231.
Mansouri, A & Ibrahim, GM 2018, 'Providing surgery for medically intractable epilepsy in low- and middle-income countries: Shifting the focus from if to how', JAMA neurology, vol. 75, no. 9, pp. 1041-1042.
Mansouri, A 2018, 'Surgery for Drug-Resistant Epilepsy in Children', The New England journal of medicine, vol. 378, no. 4.


Hachem, LD, Mansouri, A, Juraschka, K, Taslimi, S, Pirouzmand, F & Zadeh, G 2017, 'Citation classics in neuro-oncology: Assessment of historical trends and scientific progress', Neuro-oncology, vol. 19, no. 9, pp. 1158-1172.
Badhiwala, JH, Nassiri, F, Witiw, CD, Mansouri, SA, Almenawer, SA & Fehlings, MG 2017, 'Does Transection of the C2 Nerve Roots during C1 Lateral Mass Screw Placement for Atlantoaxial Fixation Result in a Superior Outcome?', Spine, vol. 42, no. 18, pp. E1067-E1076.
Alotaibi, NM, Samuel, N, Mansouri, A, Nejad, R & Macdonald, RL 2017, 'Glioblastoma Following Ischemic Stroke', The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, vol. 44, no. 6, pp. 732-733.
Mansouri, A, Witiw, CD, Badhiwala, JH, Nassiri, F, McDonald, PJ, Kulkarni, AV, Zadeh, G & Kondziolka, D 2017, 'National Perspectives on the Training of Neurosurgery Residents in Stereotactic Radiosurgery', Canadian Journal of Neurological Sciences, vol. 44, no. 1, pp. 51-58.
Mansouri, A, Ghadakzadeh, S, Maqbool, T, Barnett, C, Au, K, Kongkham, P, Bril, V & Gelareh, Z 2017, 'Neurofibromatosis Clinic: A Report on Patient Demographics and Evaluation of the Clinic', Canadian Journal of Neurological Sciences, vol. 44, no. 5, pp. 577-588.
Aldakkan, A, Mansouri, A, Jaja, BNR, Alotaibi, NM, Macdonald, RL, Noble, A, Molyneux, A, Quinn, A, Schatlo, B, Lo, B, Jaja, BNR, Johnston, C, Hanggi, D, Hasan, D, Wong, GKC, Lantigua, H, Fukuda, H, Torner, J, Singh, J, Spears, J, Schaller, K, Stienen, MN, Vergouwen, MDI, Cusimano, MD, Todd, M, Tseng, M, Le Roux, P, Macdonald, RL, Yamagata, S, Mayer, S, Schenk, T & Schweizer, TA 2017, 'Predictors of Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage with Asymptomatic Angiographic Vasospasm on Admission', World neurosurgery, vol. 97, pp. 199-204.
Jägersberg, M, Brodard, J, Qiu, J, Mansouri, A, Doglietto, F, Gentili, F, Kucharczyk, W, Fasel, J, Schaller, K & Radovanovic, I 2017, 'Quantification of Working Volumes, Exposure, and Target-Specific Maneuverability of the Pterional Craniotomy and Its Minimally Invasive Variants', World neurosurgery, vol. 101, pp. 710-717.e2.
Davidson, B, Nassiri, F, Mansouri, A, Badhiwala, JH, Witiw, CD, Shamji, MF, Peng, PW, Farb, RI & Bernstein, M 2017, 'Spontaneous Intracranial Hypotension: A Review and Introduction of an Algorithm For Management', World neurosurgery, vol. 101, pp. 343-349.
Nassiri, F, Badhiwala, JH, Witiw, CD, Mansouri, A, Davidson, B, Almenawer, SA, Lipsman, N, Da Costa, L, Pirouzmand, F & Nathens, AB 2017, 'The clinical significance of isolated traumatic subarachnoid hemorrhage in mild traumatic brain injury: A meta-analysis', Journal of Trauma and Acute Care Surgery, vol. 83, no. 4, pp. 725-731.
Nandakumar, P, Mansouri, A & Das, S 2017, 'The role of ATRX in glioma biology', Frontiers in Oncology, vol. 7, no. SEP, 236.
Aldakkan, A, Dunn, M, Warsi, NM, Mansouri, A & Marotta, TR 2017, 'Vascular Eagle’s syndrome: Two cases illustrating distinct mechanisms of cerebral ischemia', Journal of Radiology Case Reports, vol. 11, no. 8, pp. 1-7.


Nassiri, F, Ibrahim, GM, Badhiwala, JH, Witiw, CD, Mansouri, A, Alotaibi, NM & Macdonald, RL 2016, 'A Propensity Score-Matched Study of the Use of Non-steroidal Anti-inflammatory Agents Following Aneurysmal Subarachnoid Hemorrhage', Neurocritical Care, vol. 25, no. 3, pp. 351-358.
Golfinos, JG, Hill, TC, Rokosh, R, Choudhry, O, Shinseki, M, Mansouri, A, Friedmann, DR, Roland, JT & Kondziolka, D 2016, 'A matched cohort comparison of clinical outcomes following microsurgical resection or stereotactic radiosurgery for patients with small- and medium-sized vestibular schwannomas', Journal of neurosurgery, vol. 125, no. 6, pp. 1472-1482.
Fatehi Hassanabad, M, Mansouri, A, Alotaibi, NM, Hazrati, LN & Bernstein, M 2016, 'Metastatic saccrococcygeal chordoma', Journal of Clinical Neuroscience, vol. 23, pp. 149-152.
Fallah, A, Wang, AC, Weil, AG, Ibrahim, GM, Mansouri, A & Bhatia, S 2016, 'Predictors of outcome following cerebral aqueductoplasty: An individual participant data meta-analysis', Neurosurgery, vol. 78, no. 2, pp. 285-296.
Mansouri, A, Cooper, B, Shin, SM & Kondziolka, D 2016, 'Randomized controlled trials and neurosurgery: The ideal fit or should alternative methodologies be considered?', Journal of neurosurgery, vol. 124, no. 2, pp. 558-568.
Mansouri, SA, Klironomos, G, Taslimi, S, Kilian, A, Gentili, F, Khan, OH, Aldape, K & Zadeh, G 2016, 'Surgically resected skull base meningiomas demonstrate a divergent postoperative recurrence pattern compared with non-skull base meningiomas', Journal of neurosurgery, vol. 125, no. 2, pp. 431-440.
Agnihotri, S, Jalali, S, Wilson, MR, Danesh, A, Li, M, Klironomos, G, Krieger, JR, Mansouri, A, Khan, O, Mamatjan, Y, Landon-Brace, N, Tung, T, Dowar, M, Li, T, Bruce, JP, Burrell, KE, Tonge, PD, Alamsahebpour, A, Krischek, B, Agarwalla, PK, Bi, WL, Dunn, IF, Beroukhim, R, Fehlings, MG, Bril, V, Pagnotta, SM, Iavarone, A, Pugh, TJ, Aldape, KD & Zadeh, G 2016, 'The genomic landscape of schwannoma', Nature Genetics, vol. 48, no. 11, pp. 1339-1348.
Mansouri, A, Mansouri, S, Hachem, LD, Klironomos, G, Vogelbaum, MA, Bernstein, M & Zadeh, G 2016, 'The role of 5-aminolevulinic acid in enhancing surgery for high-grade glioma, its current boundaries, and future perspectives: A systematic review', Cancer, vol. 122, no. 16, pp. 2469-2478.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)