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Seyed Alireza Mansouri, MD

Seyed Alireza Mansouri, MD

Assistant Professor, Department of Neurosurgery
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies

Research Interests

  • Systematic Reviews
  • Neoplasms
  • Therapeutics
  • Glioma
  • Seizures
  • Meta-Analysis
  • Radiosurgery
  • Brain
  • Epilepsy
  • Meningioma
  • Glioblastoma
  • Confidence Intervals

Clinical Trials

Phase II Pilot RCT to assess feasibility of supra-marginal surgical resection of malignant glioma (G-SUMIT: Glioma Supra Marginal Incision Trial)
Neuro-pharmacological properties of repurposed posaconazole in glioblastoma: A Phase 0 clinical trial
NRG-BN012: A Randomized Phase III Trial of Pre-Operative Compared to Post-Operative Stereotactic Radiosurgery in Patients With Resectable Brain Metastases
3D-PREDICT Registry: 3D Prediction of patient-specific Response using ex vivo Interrogation of live cells from tumors
Neuro-pharmacological properties of repurposed ketoconazole in glioblastomas: A Phase 0 clinical trial
Prospective proteogenomic analysis of CNS tumors

Recent Publications


Shenoy, G, Slagle-Webb, B, Khunsriraksakul, C, Pandya Shesh, B, Luo, J, Khristov, V, Smith, N, Mansouri, A, Zacharia, BE, Holder, S, Lathia, JD, Barnholtz-Sloan, JS & Connor, JR 2024, 'Analysis of anemia and iron supplementation among glioblastoma patients reveals sex-biased association between anemia and survival', Scientific reports, vol. 14, no. 1, 2389.
Hect, JL, Harford, E, Maroufi, SF, Klem, ML, Mansouri, A & Abel, TJ 2024, 'Clinical outcomes of MR-guided laser interstitial thermal therapy corpus callosum ablation in drug-resistant epilepsy: a systematic review and meta-analysis', Journal of Neurosurgery: Pediatrics, vol. 33, no. 1, pp. 12-21.
Kermanshahi, N, Hamidi, N, Weisberg, J, Beg, U, Dabrowski, M, Padmanaban, V, Betz, J & Mansouri, A 2024, 'The Prevalence of Seizures in Brain Metastasis Patients on Anticonvulsant Prophylaxis: A Systematic Review and Meta-Analysis', World neurosurgery, vol. 183, pp. e613-e624.


Zuccato, JA, Patil, V, Mansouri, S, Voisin, M, Chakravarthy, A, Yi Shen, S, Nassiri, F, Mikolajewicz, N, Trifoi, M, Skakodub, A, Zacharia, B, Glantz, M, De Carvalho, DD, Mansouri, A & Zadeh, G 2023, 'Cerebrospinal fluid methylome-based liquid biopsies for accurate malignant brain neoplasm classification', Neuro-oncology, vol. 25, no. 8, pp. 1452-1460.
Tuohy, K, Ba, DM, Bhanja, D, Leslie, D, Liu, G & Mansouri, A 2023, 'Early costs and complications of first-line low-grade glioma treatment using a large national database: Limitations and future perspectives', Frontiers in Surgery, vol. 10, 1001741.
Warsi, NM, Mohammad, AH, Zhang, F, Wong, SM, Yan, H, Mansouri, A & Ibrahim, GM 2023, 'Electrocorticography-Guided Resection Enhances Postoperative Seizure Freedom in Low-Grade Tumor-Associated Epilepsy: A Systematic Review and Meta-Analysis', Neurosurgery, vol. 92, no. 1, pp. 18-26.
Sabahi, M, Salehipour, A, Bazl, MSY, Rezaei, N, Mansouri, A & Borghei-Razavi, H 2023, 'Local immunotherapy of glioblastoma: A comprehensive review of the concept', Journal of Neuroimmunology, vol. 381, 578146.
Bhanja, D, Wilding, H, Baroz, A, Trifoi, M, Shenoy, G, Slagle-Webb, B, Hayes, D, Soudagar, Y, Connor, J & Mansouri, A 2023, 'Photodynamic Therapy for Glioblastoma: Illuminating the Path toward Clinical Applicability', Cancers, vol. 15, no. 13, 3427.
Mofatteh, M, Mashayekhi, MS, Arfaie, S, Chen, Y, Malhotra, AK, Alvi, MA, Sader, N, Antonick, V, Fatehi Hassanabad, M, Mansouri, A, Das, S, Liao, X, McIntyre, RS, Del Maestro, R, Turecki, G, Cohen-Gadol, AA, Zadeh, G & Ashkan, K 2023, 'Suicidal ideation and attempts in brain tumor patients and survivors: A systematic review', Neuro-Oncology Advances, vol. 5, no. 1, vdad058.
Mansouri, A, Ibrahim, S, Bello, L, Martino, J & Velasquez, C 2023, 'The current state of the art of primary motor mapping for tumor resection: A focused survey', Clinical Neurology and Neurosurgery, vol. 229, 107685.


Mansouri, A, Lai, C, Scales, D & Pirouzmand, F 2022, 'A phase II pilot randomized controlled trial to assess the feasibility of the “supra-marginal” surgical resection of malignant glioma (G-SUMIT: Glioma supra marginal incision trial) study protocol', Pilot and Feasibility Studies, vol. 8, no. 1, 138.
Bhanja, D, Ba, D, Tuohy, K, Wilding, H, Trifoi, M, Padmanaban, V, Liu, G, Sughrue, M, Zacharia, B, Leslie, D & Mansouri, A 2022, 'Association of Low-Grade Glioma Diagnosis and Management Approach with Mental Health Disorders: A MarketScan Analysis 2005–2014', Cancers, vol. 14, no. 6, 1376.
Qazi, MA, Salim, SK, Brown, KR, Mikolajewicz, N, Savage, N, Han, H, Subapanditha, MK, Bakhshinyan, D, Nixon, A, Vora, P, Desmond, K, Chokshi, C, Singh, M, Khoo, A, Macklin, A, Khan, S, Tatari, N, Winegarden, N, Richards, L, Pugh, T, Bock, N, Mansouri, A, Venugopal, C, Kislinger, T, Goyal, S, Moffat, J & Singh, SK 2022, 'Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma', Cell Reports, vol. 40, no. 13, 111420.
Singh, K, Batich, KA, Wen, PY, Tan, AC, Bagley, SJ, Lim, M, Platten, M, Colman, H, Ashley, DM, Chang, SM, Rahman, R, Galanis, E, Mansouri, A, Puduvalli, VK, Reardon, DA, Sahebjam, S, Sampson, JH, Simes, J, Berry, DA, Zadeh, G, Cloughesy, TF, Mehta, MP, Piantadosi, S, Weller, M, Heimberger, AB & Khasraw, M 2022, 'Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma', Clinical Cancer Research, vol. 28, no. 4, pp. 585-593.
Hamidi, N, Karmur, B, Sperrazza, S, Alexieva, J, Salmi, L, Zacharia, BE, Nduom, EK, Cohen-Gadol, AA, Rutka, JT & Mansouri, A 2022, 'Guidelines for optimal utilization of social media for brain tumor stakeholders', Journal of neurosurgery, vol. 136, no. 2, pp. 335-342.
Loh, A, Germann, J, Qazi, S, Husain, R, Boutet, A, Lozano, AM & Mansouri, A 2022, 'Lesion network mapping of ectopic craniopharyngioma identifies potential cause of psychosis: a case report', Acta Neurochirurgica, vol. 164, no. 12, pp. 3285-3289.
Mikolajewicz, N, Khan, S, Trifoi, M, Skakdoub, A, Ignatchenko, V, Mansouri, S, Zuccatto, J, Zacharia, BE, Glantz, M, Zadeh, G, Moffat, J, Kislinger, T & Mansouri, A 2022, 'Leveraging the CSF proteome toward minimally-invasive diagnostics surveillance of brain malignancies', Neuro-Oncology Advances, vol. 4, no. 1, vdac161.
Lubelski, D, Pennington, Z, Ochuba, A, Azad, TD, Mansouri, A, Blakeley, J & Belzberg, AJ 2022, 'Natural History of Brachial Plexus, Peripheral Nerve, and Spinal Schwannomas', Neurosurgery, vol. 91, no. 6, pp. 883-891.
Bhanja, D, Neighbors, J, Connor, J, Zadeh, G & Mansouri, A 2022, 'Neuropharmacological Study of Posaconazole for Glioblastoma: A Phase 0 Clinical Trial Protocol', Neurosurgery, vol. 91, no. 4, pp. 658-665.
Germann, J, Zadeh, G, Mansouri, A, Kucharczyk, W, Lozano, AM & Boutet, A 2022, 'Untapped Neuroimaging Tools for Neuro-Oncology: Connectomics and Spatial Transcriptomics', Cancers, vol. 14, no. 3, 464.


Daggubati, LC, Ryan, CA, Brandon, C, Madden, DB, Farou, N, Mansouri, A & Zacharia, BE 2021, '#Neurosurgery: A Temporal and Content Analysis of Academic Neurosurgery on Twitter', World neurosurgery, vol. 153, pp. e481-e487.
Wang, R, Beg, U, Padmanaban, V, Abel, TJ, Lipsman, N, Ibrahim, GM & Mansouri, A 2021, 'A Systematic Review of Minimally Invasive Procedures for Mesial Temporal Lobe Epilepsy: Too Minimal, Too Fast?', Neurosurgery, vol. 89, no. 2, pp. 164-176.
Mansouri, A, Germann, J, Boutet, A, Elias, GJB, Karmur, B, Neudorfer, C, Loh, A, McAndrews, MP, Ibrahim, GM, Lozano, AM & Valiante, TA 2021, 'An exploratory study into the influence of laterality and location of hippocampal sclerosis on seizure prognosis and global cortical thinning', Scientific reports, vol. 11, no. 1, 4686.
Chowdhury, T, Gray, K, Sharma, M, Mau, C, McNutt, S, Ryan, C, Farou, N, Bergquist, P, Caldwell, C, Uribe, AA, Todeschini, AB, Bergese, SD, Bucher, O, Musto, G, Azazi, EA, Zadeh, G, Tsang, DS, Mansouri, SA, Kakumanu, S & Venkatraghavan, L 2022, 'Brain Cancer Progression: A Retrospective Multicenter Comparison of Awake Craniotomy Versus General Anesthesia in High-grade Glioma Resection', Journal of Neurosurgical Anesthesiology, vol. 34, no. 4, pp. 392-400.
Taslimi, S, Brar, K, Ellenbogen, Y, Deng, J, Hou, W, Moraes, FY, Glantz, M, Zacharia, BE, Tan, A, Ahluwalia, MS, Khasraw, M, Zadeh, G & Mansouri, A 2021, 'Comparative Efficacy of Systemic Agents for Brain Metastases From Non-Small-Cell Lung Cancer With an EGFR Mutation/ALK Rearrangement: A Systematic Review and Network Meta-Analysis', Frontiers in Oncology, vol. 11, 739765.
Brar, K, Taslimi, S, Ellenbogen, Y, Deng, J, Hou, W, Moraes, FY, Glantz, M, Zacharia, BE, Tan, A, Ahluwalia, MS, Khasraw, M, Zadeh, G & Mansouri, A 2022, 'Comparative Efficacy of Treatments for Brain Metastases from Non–Small Cell Lung Cancer without an EGFR-Mutation/ALK-Rearrangement: A Systematic Review and Network Meta-Analysis', World neurosurgery, vol. 158, pp. e87-e102.
Beg, U, Snyder, BM, Madhani, SI, Hamidi, N, Padmanaban, V, Tuanquin, LC, Kruser, TJ, Connor, J & Mansouri, A 2021, 'Current Landscape and Future Prospects of Radiation Sensitizers for Malignant Brain Tumors: A Systematic Review', World neurosurgery, vol. 151, pp. e839-e856.
Tuohy, K, Fernandez, A, Hamidi, N, Padmanaban, V & Mansouri, A 2021, 'Current State of Health Economic Analyses for Low-Grade Glioma Management: A Systematic Review', World neurosurgery, vol. 152, pp. 189-197.e1.
Welling, DB, Collier, KA, Burns, SS, Oblinger, JL, Shu, E, Miles-Markley, BA, Hofmeister, CC, Makary, MS, Slone, HW, Blakeley, JO, Mansouri, SA, Neff, BA, Jackler, RK, Mortazavi, A & Chang, LS 2021, 'Early phase clinical studies of AR-42, a histone deacetylase inhibitor, for neurofibromatosis type 2-associated vestibular schwannomas and meningiomas', Laryngoscope investigative otolaryngology, vol. 6, no. 5, pp. 1008-1019.
Mansouri, A, Beyn, ME, Pancholi, A, Chow, CT, Wang, R, Boutet, A, Elias, GJB, Germann, J, Loh, A, Voisin, MR, Lozano, AM, Chiocca, EA, Vogelbaum, MA & Zadeh, G 2021, 'Evolution of the Neurosurgeon's Role in Clinical Trials for Glioblastoma: A Systematic Overview of the Clinicaltrials.Gov Database', Neurosurgery, vol. 89, no. 2, pp. 196-203.
Moraes, FY, Mansouri, A, Dasgupta, A, Ramotar, M, Kosyak, N, Weiss, J, Laperriere, N, Millar, BA, Berlin, A, Conrad, T, van Prooijen, M, Heaton, R, Coolens, C, Winter, J, Bernstein, M, Zadeh, G, Kongkham, P, Doherty, M & Shultz, DB 2021, 'Impact of EGFR mutation on outcomes following SRS for brain metastases in non-small cell lung cancer', Lung Cancer, vol. 155, pp. 34-39.
Voisin, MR, Sasikumar, S, Mansouri, A & Zadeh, G 2021, 'Incidence and prevalence of primary malignant brain tumours in Canada from 1992 to 2017: an epidemiologic study', CMAJ open, vol. 9, no. 4, pp. E973-E979.
Paff, M, Boutet, A, Elias, GJB, Germann, J, Mansouri, A, Loh, A, Gwun, D, Neudorfer, C, McAndrews, MP, Gold, D, Lozano, AM & Valiante, TA 2021, 'Lateralizing magnetic resonance imaging findings in mesial temporal sclerosis and correlation with seizure and neurocognitive outcome after temporal lobectomy', Epilepsy Research, vol. 171, 106562.
Salmi, L, Alireza Mansouri, S & Taylor, LP 2021, 'New federal rule requires open notes: What do clinicians and patients need to know? Insights and suggestions from a neuro-oncologist, a neurosurgeon, and a person living with a brain tumor', Neuro-Oncology Practice, vol. 8, no. 3, pp. 233-235.
Tan, AC, Bagley, SJ, Wen, PY, Lim, M, Platten, M, Colman, H, Ashley, DM, Wick, W, Chang, SM, Galanis, E, Mansouri, A, Khagi, S, Mehta, MP, Heimberger, AB, Puduvalli, VK, Reardon, DA, Sahebjam, S, Simes, J, Antonia, SJ, Berry, D & Khasraw, M 2021, 'Systematic review of combinations of targeted or immunotherapy in advanced solid tumors', Journal for ImmunoTherapy of Cancer, vol. 9, no. 7, e002459.
Mrugala, MM, Ostrom, QT, Pressley, SM, Taylor, JW, Thomas, AA, Wefel, JS, Coven, SL, Acquaye, AA, Haynes, C, Agnihotri, S, Lim, M, Peters, KB, Sulman, EP, Salcido, JT, Butowski, NA, Hervey-Jumper, S, Mansouri, A, Oliver, KR, Porter, AB, Nassiri, F, Schiff, D, Dunbar, EM, Hegi, ME, Armstrong, TS, Van Den Bent, MJ, Chang, SM, Zadeh, G & Chheda, MG 2021, 'The state of neuro-oncology during the COVID-19 pandemic: A worldwide assessment', Neuro-Oncology Advances, vol. 3, no. 1, vdab035.
Mansouri, A, Padmanaban, V, Aregawi, D & Glantz, M 2021, 'VEGF and Immune Checkpoint Inhibition for Prevention of Brain Metastases: Systematic Review and Meta-analysis', Neurology, vol. 97, no. 15, pp. E1484-E1492.


Ye, VC, Mansouri, A, Warsi, NM & Ibrahim, GM 2021, 'Atonic seizures in children: a meta-analysis comparing corpus callosotomy to vagus nerve stimulation', Child's Nervous System, vol. 37, no. 1, pp. 259-267.
Karmur, BS, Philteos, J, Abbasian, A, Zacharia, BE, Lipsman, N, Levin, V, Grossman, S & Mansouri, A 2020, 'Blood-Brain Barrier Disruption in Neuro-Oncology: Strategies, Failures, and Challenges to Overcome', Frontiers in Oncology, vol. 10, 563840.
Mansouri, A, Brar, K & Cusimano, MD 2020, 'Considerations for a surgical RCT for diffuse low-grade glioma: A survey', Neuro-Oncology Practice, vol. 7, no. 3, pp. 338-343.
Remick, M, Ibrahim, GM, Mansouri, A & Abel, TJ 2020, 'Cross-national disparities contribute to heterogeneity in patient outcomes following invasive monitoring: A hierarchical mixed-effects analysis', Epilepsia, vol. 61, no. 9, pp. e116-e123.
Massaad, E, Hamidi, N, Goetz, J, Padmanaban, V, Mau, C, Tsang, D, de Moraes, FY, Chung, C, Zacharia, BE & Mansouri, A 2021, 'Equivalent Efficacy and Safety of Radiosurgery for Cystic and Solid Vestibular Schwannomas: A Systematic Review', World neurosurgery, vol. 146, pp. 322-331.e1.
Zuccato, JA, Aizer, AA, Lee, EQ, Ahluwalia, MS, O'Halloran, PJ, Mansouri, A, Wen, PY & Zadeh, G 2020, 'Highlights of the 2019 Society for Neuro-Oncology Inaugural Brain Metastases Conference: Establishing a dedicated meeting to address an unmet need in the field', Neuro-Oncology Advances, vol. 2, no. 1, vdaa036.
Mansouri, AM, Germann, J, Boutet, A, Elias, GJB, Mithani, K, Chow, CT, Karmur, B, Ibrahim, GM, McAndrews, MP, Lozano, AM, Zadeh, G & Valiante, TA 2020, 'Identification of neural networks preferentially engaged by epileptogenic mass lesions through lesion network mapping analysis', Scientific reports, vol. 10, no. 1, 10989.
Mansouri, A, Boutet, A, Elias, G, Germann, J, Yan, H, Babu, H, Lozano, AM & Valiante, TA 2020, 'Lesion Network Mapping Analysis Identifies Potential Cause of Postoperative Depression in a Case of Cingulate Low-Grade Glioma', World neurosurgery, vol. 133, pp. 278-282.
Brar, K, Hachem, LD, Badhiwala, JH, Mau, C, Zacharia, BE, Moraes, FYD, Pirouzmand, F & Mansouri, A 2020, 'Management of Diffuse Low-Grade Glioma: The Renaissance of Robust Evidence', Frontiers in Oncology, vol. 10, 575658.
Mansouri, A & Zadeh, G 2020, 'NCI-CONNECT rare CNS tumor initiative: Current progress and anticipated future impact', Neuro-Oncology Advances, vol. 2, no. 1, vdaa022.
Remick, M, Ibrahim, GM, Mansouri, A & Abel, TJ 2020, 'Patient phenotypes and clinical outcomes in invasive monitoring for epilepsy: An individual patient data meta-analysis', Epilepsy and Behavior, vol. 102, 106652.
Zacharia, BE, Eichberg, DG, Ivan, ME, Hanft, S, Boockvar, JA, Isildak, H, Mansouri, A, Komotar, RJ & D’Amico, RS 2020, 'Surgical management of brain tumor patients in the COVID-19 era', Neurosurgery, vol. 87, no. 2, pp. E197-E200.
Daggubati, LC, Eichberg, DG, Ivan, ME, Hanft, S, Mansouri, A, Komotar, RJ, D'Amico, RS & Zacharia, BE 2020, 'Telemedicine for Outpatient Neurosurgical Oncology Care: Lessons Learned for the Future During the COVID-19 Pandemic', World neurosurgery, vol. 139, pp. e859-e863.
Warsi, NM, Zewude, R, Karmur, B, Pirouzmand, N, Hachem, L & Mansouri, A 2020, 'The cost-effectiveness of 5-ALA in high-grade glioma surgery: A quality-based systematic review', Canadian Journal of Neurological Sciences, vol. 47, no. 6, pp. 793-799.
Warsi, NM, Karmur, BS, Brar, K, Moraes, FY, Tsang, DS, Laperriere, N, Kondziolka, D & Mansouri, A 2020, 'The role of stereotactic radiosurgery in the management of brain metastases from a health-economic perspective: A systematic review', Neurosurgery, vol. 87, no. 3, pp. 484-497.