Researcher Profile

Researcher Profile

Seyed Alireza Mansouri, MD

Seyed Alireza Mansouri, MD

Assistant Professor, Department of Neurosurgery
Scientific Program:Next-Generation Therapies
afm6068@psu.edu

Research Interests

  • Systematic Reviews
  • Neoplasms
  • Therapeutics
  • Glioma
  • Seizures
  • Radiosurgery
  • Meta-Analysis
  • Brain
  • Meningioma
  • Glioblastoma
  • Confidence Intervals
  • Epilepsy

Clinical Trials

3D-PREDICT Registry: 3D Prediction of patient-specific Response using ex vivo Interrogation of live cells from tumors
Neuro-pharmacokinetic study of posaconazole for high-grade gliomas: A Phase 0 clinical trial
Neuro-pharmacological study of ketoconazole for high-grade gliomas: A Phase 0 clinical trial

Recent Publications

2022

Mansouri, A, Lai, C, Scales, D & Pirouzmand, F 2022, 'A phase II pilot randomized controlled trial to assess the feasibility of the “supra-marginal” surgical resection of malignant glioma (G-SUMIT: Glioma supra marginal incision trial) study protocol', Pilot and Feasibility Studies, vol. 8, no. 1, 138. https://doi.org/10.1186/s40814-022-01104-1
Bhanja, D, Ba, D, Tuohy, K, Wilding, H, Trifoi, M, Padmanaban, V, Liu, G, Sughrue, M, Zacharia, B, Leslie, D & Mansouri, A 2022, 'Association of Low-Grade Glioma Diagnosis and Management Approach with Mental Health Disorders: A MarketScan Analysis 2005–2014', Cancers, vol. 14, no. 6, 1376. https://doi.org/10.3390/cancers14061376
Qazi, MA, Salim, SK, Brown, KR, Mikolajewicz, N, Savage, N, Han, H, Subapanditha, MK, Bakhshinyan, D, Nixon, A, Vora, P, Desmond, K, Chokshi, C, Singh, M, Khoo, A, Macklin, A, Khan, S, Tatari, N, Winegarden, N, Richards, L, Pugh, T, Bock, N, Mansouri, A, Venugopal, C, Kislinger, T, Goyal, S, Moffat, J & Singh, SK 2022, 'Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma', Cell Reports, vol. 40, no. 13, 111420. https://doi.org/10.1016/j.celrep.2022.111420
Singh, K, Batich, KA, Wen, PY, Tan, AC, Bagley, SJ, Lim, M, Platten, M, Colman, H, Ashley, DM, Chang, SM, Rahman, R, Galanis, E, Mansouri, A, Puduvalli, VK, Reardon, DA, Sahebjam, S, Sampson, JH, Simes, J, Berry, DA, Zadeh, G, Cloughesy, TF, Mehta, MP, Piantadosi, S, Weller, M, Heimberger, AB & Khasraw, M 2022, 'Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma', Clinical Cancer Research, vol. 28, no. 4, pp. 585-593. https://doi.org/10.1158/1078-0432.CCR-21-2681
Hamidi, N, Karmur, B, Sperrazza, S, Alexieva, J, Salmi, L, Zacharia, BE, Nduom, EK, Cohen-Gadol, AA, Rutka, JT & Mansouri, A 2022, 'Guidelines for optimal utilization of social media for brain tumor stakeholders', Journal of neurosurgery, vol. 136, no. 2, pp. 335-342. https://doi.org/10.3171/2020.11.JNS203226
Loh, A, Germann, J, Qazi, S, Husain, R, Boutet, A, Lozano, AM & Mansouri, A 2022, 'Lesion network mapping of ectopic craniopharyngioma identifies potential cause of psychosis: a case report', Acta Neurochirurgica, vol. 164, no. 12, pp. 3285-3289. https://doi.org/10.1007/s00701-022-05355-y
Mikolajewicz, N, Khan, S, Trifoi, M, Skakdoub, A, Ignatchenko, V, Mansouri, S, Zuccatto, J, Zacharia, BE, Glantz, M, Zadeh, G, Moffat, J, Kislinger, T & Mansouri, SA 2022, 'Leveraging the CSF proteome toward minimally-invasive diagnostics surveillance of brain malignancies', Neuro-Oncology Advances, vol. 4, no. 1, vdac161. https://doi.org/10.1093/noajnl/vdac161
Lubelski, D, Pennington, Z, Ochuba, A, Azad, TD, Mansouri, A, Blakeley, J & Belzberg, AJ 2022, 'Natural History of Brachial Plexus, Peripheral Nerve, and Spinal Schwannomas', Neurosurgery, vol. 91, no. 6, pp. 883-891. https://doi.org/10.1227/neu.0000000000002118
Bhanja, D, Neighbors, J, Connor, J, Zadeh, G & Mansouri, A 2022, 'Neuropharmacological Study of Posaconazole for Glioblastoma: A Phase 0 Clinical Trial Protocol', Neurosurgery, vol. 91, no. 4, pp. 658-665. https://doi.org/10.1227/neu.0000000000002071
Germann, J, Zadeh, G, Mansouri, A, Kucharczyk, W, Lozano, AM & Boutet, A 2022, 'Untapped Neuroimaging Tools for Neuro-Oncology: Connectomics and Spatial Transcriptomics', Cancers, vol. 14, no. 3, 464. https://doi.org/10.3390/cancers14030464

2021

Daggubati, LC, Ryan, CA, Brandon, C, Madden, DB, Farou, N, Mansouri, A & Zacharia, BE 2021, '#Neurosurgery: A Temporal and Content Analysis of Academic Neurosurgery on Twitter', World neurosurgery, vol. 153, pp. e481-e487. https://doi.org/10.1016/j.wneu.2021.06.150
Wang, R, Beg, U, Padmanaban, V, Abel, TJ, Lipsman, N, Ibrahim, GM & Mansouri, A 2021, 'A Systematic Review of Minimally Invasive Procedures for Mesial Temporal Lobe Epilepsy: Too Minimal, Too Fast?', Neurosurgery, vol. 89, no. 2, pp. 164-176. https://doi.org/10.1093/neuros/nyab125
Mansouri, A, Germann, J, Boutet, A, Elias, GJB, Karmur, B, Neudorfer, C, Loh, A, McAndrews, MP, Ibrahim, GM, Lozano, AM & Valiante, TA 2021, 'An exploratory study into the influence of laterality and location of hippocampal sclerosis on seizure prognosis and global cortical thinning', Scientific reports, vol. 11, no. 1, 4686. https://doi.org/10.1038/s41598-021-84281-y
Chowdhury, T, Gray, K, Sharma, M, Mau, C, McNutt, S, Ryan, C, Farou, N, Bergquist, P, Caldwell, C, Uribe, AA, Todeschini, AB, Bergese, SD, Bucher, O, Musto, G, Azazi, EA, Zadeh, G, Tsang, DS, Mansouri, SA, Kakumanu, S & Venkatraghavan, L 2022, 'Brain Cancer Progression: A Retrospective Multicenter Comparison of Awake Craniotomy Versus General Anesthesia in High-grade Glioma Resection', Journal of Neurosurgical Anesthesiology, vol. 34, no. 4, pp. 392-400. https://doi.org/10.1097/ANA.0000000000000778
Taslimi, S, Brar, K, Ellenbogen, Y, Deng, J, Hou, W, Moraes, FY, Glantz, M, Zacharia, BE, Tan, A, Ahluwalia, MS, Khasraw, M, Zadeh, G & Mansouri, A 2021, 'Comparative Efficacy of Systemic Agents for Brain Metastases From Non-Small-Cell Lung Cancer With an EGFR Mutation/ALK Rearrangement: A Systematic Review and Network Meta-Analysis', Frontiers in Oncology, vol. 11, 739765. https://doi.org/10.3389/fonc.2021.739765
Brar, K, Taslimi, S, Ellenbogen, Y, Deng, J, Hou, W, Moraes, FY, Glantz, M, Zacharia, BE, Tan, A, Ahluwalia, MS, Khasraw, M, Zadeh, G & Mansouri, A 2022, 'Comparative Efficacy of Treatments for Brain Metastases from Non–Small Cell Lung Cancer without an EGFR-Mutation/ALK-Rearrangement: A Systematic Review and Network Meta-Analysis', World neurosurgery, vol. 158, pp. e87-e102. https://doi.org/10.1016/j.wneu.2021.10.113
Beg, U, Snyder, BM, Madhani, SI, Hamidi, N, Padmanaban, V, Tuanquin, LC, Kruser, TJ, Connor, J & Mansouri, A 2021, 'Current Landscape and Future Prospects of Radiation Sensitizers for Malignant Brain Tumors: A Systematic Review', World neurosurgery, vol. 151, pp. e839-e856. https://doi.org/10.1016/j.wneu.2021.04.134
Tuohy, K, Fernandez, A, Hamidi, N, Padmanaban, V & Mansouri, A 2021, 'Current State of Health Economic Analyses for Low-Grade Glioma Management: A Systematic Review', World neurosurgery, vol. 152, pp. 189-197.e1. https://doi.org/10.1016/j.wneu.2021.05.112
Mansouri, A, Beyn, ME, Pancholi, A, Chow, CT, Wang, R, Boutet, A, Elias, GJB, Germann, J, Loh, A, Voisin, MR, Lozano, AM, Chiocca, EA, Vogelbaum, MA & Zadeh, G 2021, 'Evolution of the Neurosurgeon's Role in Clinical Trials for Glioblastoma: A Systematic Overview of the Clinicaltrials.Gov Database', Neurosurgery, vol. 89, no. 2, pp. 196-203. https://doi.org/10.1093/neuros/nyab169
Moraes, FY, Mansouri, A, Dasgupta, A, Ramotar, M, Kosyak, N, Weiss, J, Laperriere, N, Millar, BA, Berlin, A, Conrad, T, van Prooijen, M, Heaton, R, Coolens, C, Winter, J, Bernstein, M, Zadeh, G, Kongkham, P, Doherty, M & Shultz, DB 2021, 'Impact of EGFR mutation on outcomes following SRS for brain metastases in non-small cell lung cancer', Lung Cancer, vol. 155, pp. 34-39. https://doi.org/10.1016/j.lungcan.2021.02.036
Voisin, MR, Sasikumar, S, Mansouri, A & Zadeh, G 2021, 'Incidence and prevalence of primary malignant brain tumours in Canada from 1992 to 2017: an epidemiologic study', CMAJ open, vol. 9, no. 4, pp. E973-E979. https://doi.org/10.9778/cmajo.20200295
Paff, M, Boutet, A, Elias, GJB, Germann, J, Mansouri, A, Loh, A, Gwun, D, Neudorfer, C, McAndrews, MP, Gold, D, Lozano, AM & Valiante, TA 2021, 'Lateralizing magnetic resonance imaging findings in mesial temporal sclerosis and correlation with seizure and neurocognitive outcome after temporal lobectomy', Epilepsy Research, vol. 171, 106562. https://doi.org/10.1016/j.eplepsyres.2021.106562
Salmi, L, Alireza Mansouri, S & Taylor, LP 2021, 'New federal rule requires open notes: What do clinicians and patients need to know? Insights and suggestions from a neuro-oncologist, a neurosurgeon, and a person living with a brain tumor', Neuro-Oncology Practice, vol. 8, no. 3, pp. 233-235. https://doi.org/10.1093/nop/npab014
Tan, AC, Bagley, SJ, Wen, PY, Lim, M, Platten, M, Colman, H, Ashley, DM, Wick, W, Chang, SM, Galanis, E, Mansouri, A, Khagi, S, Mehta, MP, Heimberger, AB, Puduvalli, VK, Reardon, DA, Sahebjam, S, Simes, J, Antonia, SJ, Berry, D & Khasraw, M 2021, 'Systematic review of combinations of targeted or immunotherapy in advanced solid tumors', Journal for ImmunoTherapy of Cancer, vol. 9, no. 7, e002459. https://doi.org/10.1136/jitc-2021-002459
Mrugala, MM, Ostrom, QT, Pressley, SM, Taylor, JW, Thomas, AA, Wefel, JS, Coven, SL, Acquaye, AA, Haynes, C, Agnihotri, S, Lim, M, Peters, KB, Sulman, EP, Salcido, JT, Butowski, NA, Hervey-Jumper, S, Mansouri, A, Oliver, KR, Porter, AB, Nassiri, F, Schiff, D, Dunbar, EM, Hegi, ME, Armstrong, TS, Van Den Bent, MJ, Chang, SM, Zadeh, G & Chheda, MG 2021, 'The state of neuro-oncology during the COVID-19 pandemic: A worldwide assessment', Neuro-Oncology Advances, vol. 3, no. 1, vdab035. https://doi.org/10.1093/noajnl/vdab035

2020

Ye, VC, Mansouri, A, Warsi, NM & Ibrahim, GM 2021, 'Atonic seizures in children: a meta-analysis comparing corpus callosotomy to vagus nerve stimulation', Child's Nervous System, vol. 37, no. 1, pp. 259-267. https://doi.org/10.1007/s00381-020-04698-0
Karmur, BS, Philteos, J, Abbasian, A, Zacharia, BE, Lipsman, N, Levin, V, Grossman, S & Mansouri, A 2020, 'Blood-Brain Barrier Disruption in Neuro-Oncology: Strategies, Failures, and Challenges to Overcome', Frontiers in Oncology, vol. 10, 563840. https://doi.org/10.3389/fonc.2020.563840
Mansouri, A, Brar, K & Cusimano, MD 2020, 'Considerations for a surgical RCT for diffuse low-grade glioma: A survey', Neuro-Oncology Practice, vol. 7, no. 3, pp. 338-343. https://doi.org/10.1093/nop/npz058
Remick, M, Ibrahim, GM, Mansouri, A & Abel, TJ 2020, 'Cross-national disparities contribute to heterogeneity in patient outcomes following invasive monitoring: A hierarchical mixed-effects analysis', Epilepsia, vol. 61, no. 9, pp. e116-e123. https://doi.org/10.1111/epi.16647
Massaad, E, Hamidi, N, Goetz, J, Padmanaban, V, Mau, C, Tsang, D, de Moraes, FY, Chung, C, Zacharia, BE & Mansouri, A 2021, 'Equivalent Efficacy and Safety of Radiosurgery for Cystic and Solid Vestibular Schwannomas: A Systematic Review', World neurosurgery, vol. 146, pp. 322-331.e1. https://doi.org/10.1016/j.wneu.2020.11.040
Zuccato, JA, Aizer, AA, Lee, EQ, Ahluwalia, MS, O'Halloran, PJ, Mansouri, A, Wen, PY & Zadeh, G 2020, 'Highlights of the 2019 Society for Neuro-Oncology Inaugural Brain Metastases Conference: Establishing a dedicated meeting to address an unmet need in the field', Neuro-Oncology Advances, vol. 2, no. 1, vdaa036. https://doi.org/10.1093/noajnl/vdaa036
Mansouri, AM, Germann, J, Boutet, A, Elias, GJB, Mithani, K, Chow, CT, Karmur, B, Ibrahim, GM, McAndrews, MP, Lozano, AM, Zadeh, G & Valiante, TA 2020, 'Identification of neural networks preferentially engaged by epileptogenic mass lesions through lesion network mapping analysis', Scientific reports, vol. 10, no. 1, 10989. https://doi.org/10.1038/s41598-020-67626-x
Mansouri, A, Boutet, A, Elias, G, Germann, J, Yan, H, Babu, H, Lozano, AM & Valiante, TA 2020, 'Lesion Network Mapping Analysis Identifies Potential Cause of Postoperative Depression in a Case of Cingulate Low-Grade Glioma', World neurosurgery, vol. 133, pp. 278-282. https://doi.org/10.1016/j.wneu.2019.10.020
Brar, K, Hachem, LD, Badhiwala, JH, Mau, C, Zacharia, BE, Moraes, FYD, Pirouzmand, F & Mansouri, A 2020, 'Management of Diffuse Low-Grade Glioma: The Renaissance of Robust Evidence', Frontiers in Oncology, vol. 10, 575658. https://doi.org/10.3389/fonc.2020.575658
Mansouri, A & Zadeh, G 2020, 'NCI-CONNECT rare CNS tumor initiative: Current progress and anticipated future impact', Neuro-Oncology Advances, vol. 2, no. 1, vdaa022. https://doi.org/10.1093/noajnl/vdaa022
Remick, M, Ibrahim, GM, Mansouri, A & Abel, TJ 2020, 'Patient phenotypes and clinical outcomes in invasive monitoring for epilepsy: An individual patient data meta-analysis', Epilepsy and Behavior, vol. 102, 106652. https://doi.org/10.1016/j.yebeh.2019.106652
Zacharia, BE, Eichberg, DG, Ivan, ME, Hanft, S, Boockvar, JA, Isildak, H, Mansouri, A, Komotar, RJ & D’Amico, RS 2020, 'Surgical management of brain tumor patients in the COVID-19 era', Neurosurgery, vol. 87, no. 2, pp. E197-E200. https://doi.org/10.1093/neuros/nyaa162
Daggubati, LC, Eichberg, DG, Ivan, ME, Hanft, S, Mansouri, A, Komotar, RJ, D'Amico, RS & Zacharia, BE 2020, 'Telemedicine for Outpatient Neurosurgical Oncology Care: Lessons Learned for the Future During the COVID-19 Pandemic', World neurosurgery, vol. 139, pp. e859-e863. https://doi.org/10.1016/j.wneu.2020.05.140
Warsi, NM, Zewude, R, Karmur, B, Pirouzmand, N, Hachem, L & Mansouri, A 2020, 'The cost-effectiveness of 5-ALA in high-grade glioma surgery: A quality-based systematic review', Canadian Journal of Neurological Sciences, vol. 47, no. 6, pp. 793-799. https://doi.org/10.1017/cjn.2020.78
Warsi, NM, Karmur, BS, Brar, K, Moraes, FY, Tsang, DS, Laperriere, N, Kondziolka, D & Mansouri, A 2020, 'The role of stereotactic radiosurgery in the management of brain metastases from a health-economic perspective: A systematic review', Neurosurgery, vol. 87, no. 3, pp. 484-497. https://doi.org/10.1093/neuros/nyaa075

2019

International Consortium on Meningiomas 2019, 'Advances in multidisciplinary therapy for meningiomas', Neuro-oncology, vol. 21, pp. I18-I31. https://doi.org/10.1093/neuonc/noy136
Koziarz, A, Sne, N, Kegel, F, Nath, S, Badhiwala, JH, Nassiri, F, Mansouri, A, Yang, K, Zhou, Q, Rice, T, Faidi, S, Passos, E, Healey, A, Banfield, L, Mensour, M, Kirkpatrick, AW, Nassar, A, Fehlings, MG, Hawryluk, GWJ & Almenawer, SA 2019, 'Bedside optic nerve ultrasonography for diagnosing increased intracranial pressure', Annals of internal medicine, vol. 171, no. 12, pp. 896-905. https://doi.org/10.7326/M19-0812
Harmsen, IE, Elias, GJB, Beyn, ME, Boutet, A, Pancholi, A, Germann, J, Mansouri, A, Lozano, CS & Lozano, AM 2020, 'Clinical trials for deep brain stimulation: Current state of affairs', Brain Stimulation, vol. 13, no. 2, pp. 378-385. https://doi.org/10.1016/j.brs.2019.11.008
Badhiwala, JH, Witiw, CD, Nassiri, F, Akbar, MA, Mansouri, A, Wilson, JR & Fehlings, MG 2019, 'Efficacy and safety of surgery for mild degenerative cervical myelopathy: results of the aospine North America and international prospective multicenter studies', Clinical Neurosurgery, vol. 84, no. 4, pp. 890-897. https://doi.org/10.1093/neuros/nyy133
International Consortium on Meningiomas 2019, 'Imaging and diagnostic advances for intracranial meningiomas', Neuro-oncology, vol. 21, pp. I44-I61. https://doi.org/10.1093/neuonc/noy143
Badhiwala, JH, Nassiri, F, Witiw, CD, Mansouri, SA, Almenawer, SA, Da Costa, L, Fehlings, MG & Wilson, JR 2019, 'Investigating the utility of intraoperative neurophysiological monitoring for anterior cervical discectomy and fusion: Analysis of over 140,000 cases from the National (Nationwide) Inpatient Sample data set', Journal of Neurosurgery: Spine, vol. 31, no. 1, pp. 76-86. https://doi.org/10.3171/2019.1.SPINE181110
Agnihotri, S, Mansouri, S, Burrell, K, Li, M, Mamatjan, Y, Liu, J, Nejad, R, Kumar, S, Jalali, S, Singh, SK, Vartanian, A, Chen, EX, Karimi, S, Singh, O, Bunda, S, Mansouri, A, Aldape, KD & Zadeh, G 2019, 'Ketoconazole and Posaconazole Selectively Target HK2-expressing Glioblastoma Cells', Clinical Cancer Research, vol. 25, no. 2, pp. 844-855. https://doi.org/10.1158/1078-0432.CCR-18-1854
International Consortium on Meningiomas 2019, 'Life after surgical resection of a meningioma: A prospective cross-sectional study evaluating health-related quality of life', Neuro-oncology, vol. 21, pp. I32-I43. https://doi.org/10.1093/neuonc/noy152
Philteos, J, Karmur, BS & Mansouri, A 2019, 'MGMT Testing in Glioblastomas', American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 42, no. 2, pp. 117-122. https://doi.org/10.1097/COC.0000000000000490
Mansouri, A, Hachem, LD, Mansouri, S, Nassiri, F, Laperriere, NJ, Xia, D, Lindeman, NI, Wen, PY, Chakravarti, A, Mehta, MP, Hegi, ME, Stupp, R, Aldape, KD & Zadeh, G 2019, 'MGMT promoter methylation status testing to guide therapy for glioblastoma: Refining the approach based on emerging evidence and current challenges', Neuro-oncology, vol. 21, no. 2, pp. 167-178. https://doi.org/10.1093/neuonc/noy132
Yan, H, Katz, JS, Anderson, M, Mansouri, SA, Remick, M, Ibrahim, GM & Abel, TJ 2019, 'Method of invasive monitoring in epilepsy surgery and seizure freedom and morbidity: A systematic review', Epilepsia, vol. 60, no. 9, pp. 1960-1972. https://doi.org/10.1111/epi.16315
International Consortium on Meningiomas 2019, 'Molecular and translational advances in meningiomas', Neuro-oncology, vol. 21, pp. I4-I17. https://doi.org/10.1093/neuonc/noy178
Taslimi, S, Zuccato, JA, Mansouri, A, Hachem, LD, Badhiwala, J, Kuchta, J, Chen, J & Pirouzmand, F 2019, 'Novel Statistical Analyses to Assess Hearing Outcomes After ABI Implantation in NF2 Patients: Systematic Review and Individualized Patient Data Analysis', World neurosurgery, vol. 128, pp. e669-e682. https://doi.org/10.1016/j.wneu.2019.04.232
Almeida, JP, Sanchez, MM, Karekezi, C, Warsi, N, Fernández-Gajardo, R, Panwar, J, Mansouri, A, Suppiah, S, Nassiri, F, Nejad, R, Kucharczyk, W, Ridout, R, Joaquim, AF, Gentili, F & Zadeh, G 2019, 'Pituitary Apoplexy: Results of Surgical and Conservative Management Clinical Series and Review of the Literature', World neurosurgery, vol. 130, pp. e988-e999. https://doi.org/10.1016/j.wneu.2019.07.055
Glicksman, RM, Tjong, MC, Neves-Junior, WFP, Spratt, DE, Chua, KLM, Mansouri, A, Chua, MLK, Berlin, A, Winter, JD, Dahele, M, Slotman, BJ, Bilsky, M, Shultz, DB, Maldaun, M, Szerlip, N, Lo, SS, Yamada, Y, Vera-Badillo, FE, Marta, GN & Moraes, FY 2019, 'Stereotactic Ablative Radiotherapy for the Management of Spinal Metastases: A Review', JAMA Oncology. https://doi.org/10.1001/jamaoncol.2019.5351
Mansouri, A, Taslimi, S, Abbasian, A, Badhiwala, JH, Akbar, MA, Alotaibi, NM, Almenawer, SA, Weil, AG, Fallah, A, Carmant, L & Ibrahim, GM 2019, 'Surgical outcomes for medically intractable epilepsy in low- and middle-income countries: A systematic review and meta-analysis', Journal of neurosurgery, vol. 131, no. 4, pp. 1068-1078. https://doi.org/10.3171/2018.5.JNS18599

Clinical Trials Search


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Adults (age >= 18 years)