Seyed Alireza Mansouri, MD - Penn State Cancer Institute
Researcher Profile
Seyed Alireza Mansouri, MD
Assistant Professor, Department of Neurosurgery
Penn State Neuroscience Institute
Penn State Neuroscience Institute
Scientific Program:Next-Generation Therapies
Clinical Trials
Integration of CSF proteogenomics in the diagnosis and management of diffuse gliomas
Phase II Pilot RCT to assess feasibility of supra-marginal surgical resection of malignant glioma (G-SUMIT: Glioma Supra Marginal Incision Trial)
Neuro-pharmacological properties of repurposed posaconazole in glioblastoma: A Phase 0 clinical trial
NRG-BN012: A Randomized Phase III Trial of Pre-Operative Compared to Post-Operative Stereotactic Radiosurgery in Patients With Resectable Brain Metastases
3D-PREDICT Registry: 3D Prediction of patient-specific Response using ex vivo Interrogation of live cells from tumors
Neuro-pharmacological properties of repurposed ketoconazole in glioblastomas: A Phase 0 clinical trial
Prospective proteogenomic analysis of CNS tumors
Recent Publications
2024
Shenoy, G, Slagle-Webb, B, Khunsriraksakul, C, Pandya Shesh, B, Luo, J, Khristov, V, Smith, N, Mansouri, A, Zacharia, BE, Holder, S, Lathia, JD, Barnholtz-Sloan, JS & Connor, JR 2024, 'Analysis of anemia and iron supplementation among glioblastoma patients reveals sex-biased association between anemia and survival', Scientific reports, vol. 14, no. 1, 2389. https://doi.org/10.1038/s41598-024-52492-8
Mansouri, A, Nassiri, F, Scales, D & Pirouzmand, F 2024, 'Anticoagulation Therapy Timing in patients with Atrial Fibrillation after Acute and Chronic Subdural Haematoma (ATTAACH): A pilot randomised controlled trial', BMJ open, vol. 14, no. 10, e090224. https://doi.org/10.1136/bmjopen-2024-090224
Sabahi, M, Fathi Jouzdani, A, Sadeghian, Z, Dabbagh Ohadi, MA, Sultan, H, Salehipour, A, Maniakhina, L, Rezaei, N, Adada, B, Mansouri, A & Borghei-Razavi, H 2024, 'CAR-engineered NK cells versus CAR T cells in treatment of glioblastoma; strength and flaws', Journal of neuro-oncology. https://doi.org/10.1007/s11060-024-04876-z
Hect, JL, Harford, E, Maroufi, SF, Klem, ML, Mansouri, A & Abel, TJ 2024, 'Clinical outcomes of MR-guided laser interstitial thermal therapy corpus callosum ablation in drug-resistant epilepsy: a systematic review and meta-analysis', Journal of Neurosurgery: Pediatrics, vol. 33, no. 1, pp. 12-21. https://doi.org/10.3171/2023.9.PEDS23326
de Macêdo Filho, LJM, Mansouri, A, Otamendi-Lopez, A, Sarigul, B, Diógenes, AVG, Carate, CK, Torquato, GCP, de Andrade, PP & Rizk, E 2024, 'Congenital Pediatric Hydrocephalus in the Brazilian Public Health System: The Reality of a Middle-Income Country in the Past 13 Years', World neurosurgery, vol. 181, pp. e801-e808. https://doi.org/10.1016/j.wneu.2023.10.137
Ledford, A, Rodriguez, A, Lipinski, L, Abad, A, Fenstermaker, R, Edenfield, J, Kanos, C, Redjal, N, Mansouri, A, Zacharia, B, Butowski, N, Liu, J, Han, SJ, Ziu, M, Cohen, AL, Fabiano, AJ, Miles, K, Rayner, M, Thompson, J, Tollison, K, Azimzadeh, P, Holmes, L, Gevaert, M & DesRochers, TM 2024, 'Functional prediction of response to therapy prior to therapeutic intervention is associated with improved survival in patients with high-grade glioma', Scientific reports, vol. 14, no. 1, 19474. https://doi.org/10.1038/s41598-024-68801-0
Ghorbani, A, Chatanaka, MK, Avery, LM, Wang, M, Brown, J, Cohen, R, Gorham, T, Misaghian, S, Padmanabhan, N, Romero, D, Stengelin, M, Mathew, A, Sigal, G, Wohlstadter, J, Horbinski, C, McCortney, K, Xu, W, Zadeh, G, Mansouri, A, Yousef, GM, Diamandis, EP & Prassas, I 2024, 'Glial fibrillary acidic protein, neurofilament light, matrix metalloprotease 3 and fatty acid binding protein 4 as non-invasive brain tumor biomarkers', Clinical Proteomics, vol. 21, no. 1, 41. https://doi.org/10.1186/s12014-024-09492-7
Badani, A, Ozair, A, Khasraw, M, Woodworth, GF, Tiwari, P, Ahluwalia, MS & Mansouri, A 2024, 'Immune checkpoint inhibitors for glioblastoma: emerging science, clinical advances, and future directions', Journal of neuro-oncology. https://doi.org/10.1007/s11060-024-04881-2
Ozair, A, Wilding, H, Bhanja, D, Mikolajewicz, N, Glantz, M, Grossman, SA, Sahgal, A, Le Rhun, E, Weller, M, Weiss, T, Batchelor, TT, Wen, PY, Haas-Kogan, DA, Khasraw, M, Rudà, R, Soffietti, R, Vollmuth, P, Subbiah, V, Bettegowda, C, Pham, LC, Woodworth, GF, Ahluwalia, MS & Mansouri, A 2024, 'Leptomeningeal metastatic disease: new frontiers and future directions', Nature Reviews Clinical Oncology. https://doi.org/10.1038/s41571-024-00970-3
Mikolajewicz, N, Yee, PP, Bhanja, D, Trifoi, M, Miller, AM, Metellus, P, Bagley, SJ, Balaj, L, De MacEdo Filho, LJM, Zacharia, BE, Aregawi, D, Glantz, M, Weller, M, Ahluwalia, MS, Kislinger, T & Mansouri, SA 2024, 'Systematic Review of Cerebrospinal Fluid Biomarker Discovery in Neuro-Oncology: A Roadmap to Standardization and Clinical Application', Journal of Clinical Oncology, vol. 42, no. 16, pp. 1961-1974. https://doi.org/10.1200/JCO.23.01621
Kermanshahi, N, Hamidi, N, Weisberg, J, Beg, U, Dabrowski, M, Padmanaban, V, Betz, J & Mansouri, A 2024, 'The Prevalence of Seizures in Brain Metastasis Patients on Anticonvulsant Prophylaxis: A Systematic Review and Meta-Analysis', World neurosurgery, vol. 183, pp. e613-e624. https://doi.org/10.1016/j.wneu.2023.12.154
Metellus, P, Camilla, C, Bialecki, E, Beaufils, N, Vellutini, C, Pellegrino, E, Tomasini, P, Ahluwalia, MS, Mansouri, A, Nanni, I & Ouafik, LH 2024, 'The landscape of cancer-associated transcript fusions in adult brain tumors: a longitudinal assessment in 140 patients with cerebral gliomas and brain metastases', Frontiers in Oncology, vol. 14, 1382394. https://doi.org/10.3389/fonc.2024.1382394
2023
Tavallaii, A & Mansouri, A 2023, Awake Craniotomy for Tumor Surgery <Awake Craniotomy, Tumor, Mapping> in The Principles of Successful Awake Craniotomy: Perioperative Tips and Tricks. Springer Nature, pp. 9-27. https://doi.org/10.1007/978-981-99-2985-6_2
Zuccato, JA, Patil, V, Mansouri, S, Voisin, M, Chakravarthy, A, Yi Shen, S, Nassiri, F, Mikolajewicz, N, Trifoi, M, Skakodub, A, Zacharia, B, Glantz, M, De Carvalho, DD, Mansouri, A & Zadeh, G 2023, 'Cerebrospinal fluid methylome-based liquid biopsies for accurate malignant brain neoplasm classification', Neuro-oncology, vol. 25, no. 8, pp. 1452-1460. https://doi.org/10.1093/neuonc/noac264
Tuohy, K, Ba, DM, Bhanja, D, Leslie, D, Liu, G & Mansouri, A 2023, 'Early costs and complications of first-line low-grade glioma treatment using a large national database: Limitations and future perspectives', Frontiers in Surgery, vol. 10, 1001741. https://doi.org/10.3389/fsurg.2023.1001741
Warsi, NM, Mohammad, AH, Zhang, F, Wong, SM, Yan, H, Mansouri, A & Ibrahim, GM 2023, 'Electrocorticography-Guided Resection Enhances Postoperative Seizure Freedom in Low-Grade Tumor-Associated Epilepsy: A Systematic Review and Meta-Analysis', Neurosurgery, vol. 92, no. 1, pp. 18-26. https://doi.org/10.1227/neu.0000000000002182
Pascual, JSG & Mansouri, A 2023, Intraoperative Nuances of Awake Craniotomy <Surgical Nuances, Awake Craniotomy> in The Principles of Successful Awake Craniotomy: Perioperative Tips and Tricks. Springer Nature, pp. 87-95. https://doi.org/10.1007/978-981-99-2985-6_7
Sabahi, M, Salehipour, A, Bazl, MSY, Rezaei, N, Mansouri, A & Borghei-Razavi, H 2023, 'Local immunotherapy of glioblastoma: A comprehensive review of the concept', Journal of Neuroimmunology, vol. 381, 578146. https://doi.org/10.1016/j.jneuroim.2023.578146
Bhanja, D, Wilding, H, Baroz, A, Trifoi, M, Shenoy, G, Slagle-Webb, B, Hayes, D, Soudagar, Y, Connor, J & Mansouri, A 2023, 'Photodynamic Therapy for Glioblastoma: Illuminating the Path toward Clinical Applicability', Cancers, vol. 15, no. 13, 3427. https://doi.org/10.3390/cancers15133427
Mofatteh, M, Mashayekhi, MS, Arfaie, S, Chen, Y, Malhotra, AK, Alvi, MA, Sader, N, Antonick, V, Fatehi Hassanabad, M, Mansouri, A, Das, S, Liao, X, McIntyre, RS, Del Maestro, R, Turecki, G, Cohen-Gadol, AA, Zadeh, G & Ashkan, K 2023, 'Suicidal ideation and attempts in brain tumor patients and survivors: A systematic review', Neuro-Oncology Advances, vol. 5, no. 1, vdad058. https://doi.org/10.1093/noajnl/vdad058
Mansouri, A, Ibrahim, S, Bello, L, Martino, J & Velasquez, C 2023, 'The current state of the art of primary motor mapping for tumor resection: A focused survey', Clinical Neurology and Neurosurgery, vol. 229, 107685. https://doi.org/10.1016/j.clineuro.2023.107685
2022
Mansouri, A, Lai, C, Scales, D & Pirouzmand, F 2022, 'A phase II pilot randomized controlled trial to assess the feasibility of the “supra-marginal” surgical resection of malignant glioma (G-SUMIT: Glioma supra marginal incision trial) study protocol', Pilot and Feasibility Studies, vol. 8, no. 1, 138. https://doi.org/10.1186/s40814-022-01104-1
Bhanja, D, Ba, D, Tuohy, K, Wilding, H, Trifoi, M, Padmanaban, V, Liu, G, Sughrue, M, Zacharia, B, Leslie, D & Mansouri, A 2022, 'Association of Low-Grade Glioma Diagnosis and Management Approach with Mental Health Disorders: A MarketScan Analysis 2005–2014', Cancers, vol. 14, no. 6, 1376. https://doi.org/10.3390/cancers14061376
Qazi, MA, Salim, SK, Brown, KR, Mikolajewicz, N, Savage, N, Han, H, Subapanditha, MK, Bakhshinyan, D, Nixon, A, Vora, P, Desmond, K, Chokshi, C, Singh, M, Khoo, A, Macklin, A, Khan, S, Tatari, N, Winegarden, N, Richards, L, Pugh, T, Bock, N, Mansouri, A, Venugopal, C, Kislinger, T, Goyal, S, Moffat, J & Singh, SK 2022, 'Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma', Cell Reports, vol. 40, no. 13, 111420. https://doi.org/10.1016/j.celrep.2022.111420
Singh, K, Batich, KA, Wen, PY, Tan, AC, Bagley, SJ, Lim, M, Platten, M, Colman, H, Ashley, DM, Chang, SM, Rahman, R, Galanis, E, Mansouri, A, Puduvalli, VK, Reardon, DA, Sahebjam, S, Sampson, JH, Simes, J, Berry, DA, Zadeh, G, Cloughesy, TF, Mehta, MP, Piantadosi, S, Weller, M, Heimberger, AB & Khasraw, M 2022, 'Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma', Clinical Cancer Research, vol. 28, no. 4, pp. 585-593. https://doi.org/10.1158/1078-0432.CCR-21-2681
EORTC BTG, ICOM, EANO, SNO, RANO-PRO, BNOS, SBNS, BIMS, TBTC, International Brain Tumour Alliance, Brainstrust, and Brain Tumour Foundation of Canada 2022, 'Development of 'Core Outcome Sets' for Meningioma in Clinical Studies (The COSMIC Project): protocol for two systematic literature reviews, eDelphi surveys and online consensus meetings', BMJ open, vol. 12, no. 5, e057384. https://doi.org/10.1136/bmjopen-2021-057384
Hamidi, N, Karmur, B, Sperrazza, S, Alexieva, J, Salmi, L, Zacharia, BE, Nduom, EK, Cohen-Gadol, AA, Rutka, JT & Mansouri, A 2022, 'Guidelines for optimal utilization of social media for brain tumor stakeholders', Journal of neurosurgery, vol. 136, no. 2, pp. 335-342. https://doi.org/10.3171/2020.11.JNS203226
Loh, A, Germann, J, Qazi, S, Husain, R, Boutet, A, Lozano, AM & Mansouri, A 2022, 'Lesion network mapping of ectopic craniopharyngioma identifies potential cause of psychosis: a case report', Acta Neurochirurgica, vol. 164, no. 12, pp. 3285-3289. https://doi.org/10.1007/s00701-022-05355-y
Mikolajewicz, N, Khan, S, Trifoi, M, Skakdoub, A, Ignatchenko, V, Mansouri, S, Zuccatto, J, Zacharia, BE, Glantz, M, Zadeh, G, Moffat, J, Kislinger, T & Mansouri, A 2022, 'Leveraging the CSF proteome toward minimally-invasive diagnostics surveillance of brain malignancies', Neuro-Oncology Advances, vol. 4, no. 1, vdac161. https://doi.org/10.1093/noajnl/vdac161
Lubelski, D, Pennington, Z, Ochuba, A, Azad, TD, Mansouri, A, Blakeley, J & Belzberg, AJ 2022, 'Natural History of Brachial Plexus, Peripheral Nerve, and Spinal Schwannomas', Neurosurgery, vol. 91, no. 6, pp. 883-891. https://doi.org/10.1227/neu.0000000000002118
Bhanja, D, Neighbors, J, Connor, J, Zadeh, G & Mansouri, A 2022, 'Neuropharmacological Study of Posaconazole for Glioblastoma: A Phase 0 Clinical Trial Protocol', Neurosurgery, vol. 91, no. 4, pp. 658-665. https://doi.org/10.1227/neu.0000000000002071
Germann, J, Zadeh, G, Mansouri, A, Kucharczyk, W, Lozano, AM & Boutet, A 2022, 'Untapped Neuroimaging Tools for Neuro-Oncology: Connectomics and Spatial Transcriptomics', Cancers, vol. 14, no. 3, 464. https://doi.org/10.3390/cancers14030464
2021
Daggubati, LC, Ryan, CA, Brandon, C, Madden, DB, Farou, N, Mansouri, A & Zacharia, BE 2021, '#Neurosurgery: A Temporal and Content Analysis of Academic Neurosurgery on Twitter', World neurosurgery, vol. 153, pp. e481-e487. https://doi.org/10.1016/j.wneu.2021.06.150
Wang, R, Beg, U, Padmanaban, V, Abel, TJ, Lipsman, N, Ibrahim, GM & Mansouri, A 2021, 'A Systematic Review of Minimally Invasive Procedures for Mesial Temporal Lobe Epilepsy: Too Minimal, Too Fast?', Neurosurgery, vol. 89, no. 2, pp. 164-176. https://doi.org/10.1093/neuros/nyab125
Mansouri, A, Germann, J, Boutet, A, Elias, GJB, Karmur, B, Neudorfer, C, Loh, A, McAndrews, MP, Ibrahim, GM, Lozano, AM & Valiante, TA 2021, 'An exploratory study into the influence of laterality and location of hippocampal sclerosis on seizure prognosis and global cortical thinning', Scientific reports, vol. 11, no. 1, 4686. https://doi.org/10.1038/s41598-021-84281-y
Chowdhury, T, Gray, K, Sharma, M, Mau, C, McNutt, S, Ryan, C, Farou, N, Bergquist, P, Caldwell, C, Uribe, AA, Todeschini, AB, Bergese, SD, Bucher, O, Musto, G, Azazi, EA, Zadeh, G, Tsang, DS, Mansouri, SA, Kakumanu, S & Venkatraghavan, L 2022, 'Brain Cancer Progression: A Retrospective Multicenter Comparison of Awake Craniotomy Versus General Anesthesia in High-grade Glioma Resection', Journal of Neurosurgical Anesthesiology, vol. 34, no. 4, pp. 392-400. https://doi.org/10.1097/ANA.0000000000000778
Taslimi, S, Brar, K, Ellenbogen, Y, Deng, J, Hou, W, Moraes, FY, Glantz, M, Zacharia, BE, Tan, A, Ahluwalia, MS, Khasraw, M, Zadeh, G & Mansouri, A 2021, 'Comparative Efficacy of Systemic Agents for Brain Metastases From Non-Small-Cell Lung Cancer With an EGFR Mutation/ALK Rearrangement: A Systematic Review and Network Meta-Analysis', Frontiers in Oncology, vol. 11, 739765. https://doi.org/10.3389/fonc.2021.739765
Brar, K, Taslimi, S, Ellenbogen, Y, Deng, J, Hou, W, Moraes, FY, Glantz, M, Zacharia, BE, Tan, A, Ahluwalia, MS, Khasraw, M, Zadeh, G & Mansouri, A 2022, 'Comparative Efficacy of Treatments for Brain Metastases from Non–Small Cell Lung Cancer without an EGFR-Mutation/ALK-Rearrangement: A Systematic Review and Network Meta-Analysis', World neurosurgery, vol. 158, pp. e87-e102. https://doi.org/10.1016/j.wneu.2021.10.113
Beg, U, Snyder, BM, Madhani, SI, Hamidi, N, Padmanaban, V, Tuanquin, LC, Kruser, TJ, Connor, J & Mansouri, A 2021, 'Current Landscape and Future Prospects of Radiation Sensitizers for Malignant Brain Tumors: A Systematic Review', World neurosurgery, vol. 151, pp. e839-e856. https://doi.org/10.1016/j.wneu.2021.04.134
Tuohy, K, Fernandez, A, Hamidi, N, Padmanaban, V & Mansouri, A 2021, 'Current State of Health Economic Analyses for Low-Grade Glioma Management: A Systematic Review', World neurosurgery, vol. 152, pp. 189-197.e1. https://doi.org/10.1016/j.wneu.2021.05.112
Welling, DB, Collier, KA, Burns, SS, Oblinger, JL, Shu, E, Miles-Markley, BA, Hofmeister, CC, Makary, MS, Slone, HW, Blakeley, JO, Mansouri, SA, Neff, BA, Jackler, RK, Mortazavi, A & Chang, LS 2021, 'Early phase clinical studies of AR-42, a histone deacetylase inhibitor, for neurofibromatosis type 2-associated vestibular schwannomas and meningiomas', Laryngoscope investigative otolaryngology, vol. 6, no. 5, pp. 1008-1019. https://doi.org/10.1002/lio2.643
Mansouri, A, Beyn, ME, Pancholi, A, Chow, CT, Wang, R, Boutet, A, Elias, GJB, Germann, J, Loh, A, Voisin, MR, Lozano, AM, Chiocca, EA, Vogelbaum, MA & Zadeh, G 2021, 'Evolution of the Neurosurgeon's Role in Clinical Trials for Glioblastoma: A Systematic Overview of the Clinicaltrials.Gov Database', Neurosurgery, vol. 89, no. 2, pp. 196-203. https://doi.org/10.1093/neuros/nyab169
Moraes, FY, Mansouri, A, Dasgupta, A, Ramotar, M, Kosyak, N, Weiss, J, Laperriere, N, Millar, BA, Berlin, A, Conrad, T, van Prooijen, M, Heaton, R, Coolens, C, Winter, J, Bernstein, M, Zadeh, G, Kongkham, P, Doherty, M & Shultz, DB 2021, 'Impact of EGFR mutation on outcomes following SRS for brain metastases in non-small cell lung cancer', Lung Cancer, vol. 155, pp. 34-39. https://doi.org/10.1016/j.lungcan.2021.02.036
Voisin, MR, Sasikumar, S, Mansouri, A & Zadeh, G 2021, 'Incidence and prevalence of primary malignant brain tumours in Canada from 1992 to 2017: an epidemiologic study', CMAJ open, vol. 9, no. 4, pp. E973-E979. https://doi.org/10.9778/cmajo.20200295
Paff, M, Boutet, A, Elias, GJB, Germann, J, Mansouri, A, Loh, A, Gwun, D, Neudorfer, C, McAndrews, MP, Gold, D, Lozano, AM & Valiante, TA 2021, 'Lateralizing magnetic resonance imaging findings in mesial temporal sclerosis and correlation with seizure and neurocognitive outcome after temporal lobectomy', Epilepsy Research, vol. 171, 106562. https://doi.org/10.1016/j.eplepsyres.2021.106562
Salmi, L, Alireza Mansouri, S & Taylor, LP 2021, 'New federal rule requires open notes: What do clinicians and patients need to know? Insights and suggestions from a neuro-oncologist, a neurosurgeon, and a person living with a brain tumor', Neuro-Oncology Practice, vol. 8, no. 3, pp. 233-235. https://doi.org/10.1093/nop/npab014
Tan, AC, Bagley, SJ, Wen, PY, Lim, M, Platten, M, Colman, H, Ashley, DM, Wick, W, Chang, SM, Galanis, E, Mansouri, A, Khagi, S, Mehta, MP, Heimberger, AB, Puduvalli, VK, Reardon, DA, Sahebjam, S, Simes, J, Antonia, SJ, Berry, D & Khasraw, M 2021, 'Systematic review of combinations of targeted or immunotherapy in advanced solid tumors', Journal for ImmunoTherapy of Cancer, vol. 9, no. 7, e002459. https://doi.org/10.1136/jitc-2021-002459
Mrugala, MM, Ostrom, QT, Pressley, SM, Taylor, JW, Thomas, AA, Wefel, JS, Coven, SL, Acquaye, AA, Haynes, C, Agnihotri, S, Lim, M, Peters, KB, Sulman, EP, Salcido, JT, Butowski, NA, Hervey-Jumper, S, Mansouri, A, Oliver, KR, Porter, AB, Nassiri, F, Schiff, D, Dunbar, EM, Hegi, ME, Armstrong, TS, Van Den Bent, MJ, Chang, SM, Zadeh, G & Chheda, MG 2021, 'The state of neuro-oncology during the COVID-19 pandemic: A worldwide assessment', Neuro-Oncology Advances, vol. 3, no. 1, vdab035. https://doi.org/10.1093/noajnl/vdab035
Mansouri, A, Padmanaban, V, Aregawi, D & Glantz, M 2021, 'VEGF and Immune Checkpoint Inhibition for Prevention of Brain Metastases: Systematic Review and Meta-analysis', Neurology, vol. 97, no. 15, pp. E1484-E1492. https://doi.org/10.1212/WNL.0000000000012642