Jonathan Stine, MD, MSc - Penn State Cancer Institute
Researcher Profile
Jonathan Stine, MD, MSc
Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Professor, Department of Public Health Sciences
Associate Professor, Department of Medicine
Associate Professor, Department of Public Health Sciences
Director of Research, Penn State Liver Center
Division of Gastroenterology and Hepatology
Professor, Department of Public Health Sciences
Associate Professor, Department of Medicine
Associate Professor, Department of Public Health Sciences
Director of Research, Penn State Liver Center
Scientific Program:Cancer Control
Recent Publications
2025
Sogbe, M, Hummer, B, Stine, JG, Lizaola-Mayo, B, Forman, DE, Vargas, HE & Duarte-Rojo, A 2025, 'Advanced Liver Fibrosis Impairs Cardiorespiratory Fitness in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease', Digestive Diseases and Sciences, vol. 70, no. 4, pp. 1530-1539. https://doi.org/10.1007/s10620-025-08893-4
Keating, SE, Owen, PJ, Pugh, CJA, Cuthbertson, DJ & Stine, JG 2025, 'Aerobic exercise interventions lead to MASH resolution in clinical trials: Pooled analysis using the MASH resolution index', Hepatology Communications, vol. 9, no. 4, e0681. https://doi.org/10.1097/HC9.0000000000000681
Kehar, M, Huerta-Saenz, L, Strain, J, Kawesa, S, Yaraskavitch, J, Stine, J & Longmuir, PE 2025, 'Challenges in Promoting Physical Activity for Managing MASLD in Canadian Children: Insights and Barriers', Digestive Diseases and Sciences, vol. 70, no. 4, 100182, pp. 1368-1374. https://doi.org/10.1007/s10620-025-08910-6
Stine, JG, Bradley, D, McCall-Hosenfeld, J, Motz-Patel, V, Tondt, J, Batra, S, Fitzgerald, B, Garcia, S, Hummer, B, Kindrew, C, Koppenhaver, A, Mohr, H, Smith, N, Tressler, H, Vankirk, K, Krok, K, Schreibman, I, Stonesifer, E & Clarke, K 2025, 'Multidisciplinary clinic model enhances liver and metabolic health outcomes in adults with MASH', Hepatology Communications, vol. 9, no. 2, e0649. https://doi.org/10.1097/HC9.0000000000000649
Channapragada, T & Stine, JG 2025, 'Sarcopenic Obesity and MASLD: A Dangerous Duo Driving Deadly Cardiometabolic Risk', Digestive Diseases and Sciences. https://doi.org/10.1007/s10620-025-09107-7
Marjot, T, Armstrong, MJ & Stine, JG 2025, 'Skeletal muscle and MASLD: Mechanistic and clinical insights', Hepatology Communications, vol. 9, no. 6, e0711. https://doi.org/10.1097/HC9.0000000000000711
Alabdul Razzak, I, Fares, A, Stine, JG & Trivedi, HD 2025, 'The Role of Exercise in Steatotic Liver Diseases: An Updated Perspective', Liver International, vol. 45, no. 1, e16220. https://doi.org/10.1111/liv.16220
2024
Kassa, AP & Stine, JG 2024, '(P)rehabilitation in advanced chronic liver disease (advCLD): From basic exercise concepts to implementation challenges', Clinical Liver Disease, vol. 23, no. 1, e0184. https://doi.org/10.1097/CLD.0000000000000184
Stine, JG, Hummer, B, Smith, N, Tressler, H, Westley Heinle, J, VanKirk, K, Harris, S, Moeller, M, Luzier, G, DiJoseph, K, Hussaini, Z, Jackson, R, Rodgers, B, Schreibman, I, Stonesifer, E, Tondt, J, Sica, CT, Nighot, P, Chinchilli, VM, Loomba, R, Sciamanna, C, Schmitz, K & Kimball, S 2024, 'AMPED study: Protocol for a randomized controlled trial of different doses of aerobic exercise training', Hepatology Communications, vol. 8, no. 7, e0464. https://doi.org/10.1097/HC9.0000000000000464
Kurth, JD, Sciamanna, CN, Herrell, C, Moeller, M & Stine, JG 2024, 'Comparing preferences to evaluations of barrier self-efficacy for two strength training programs in US older adults', PloS one, vol. 19, no. 5 May, e0302892. https://doi.org/10.1371/journal.pone.0302892
Albhaisi, S, Tondt, J, Cyrus, J, Chinchilli, VM, Conroy, DE & Stine, JG 2024, 'Digital therapeutics lead to clinically significant body weight loss in patients with metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis', Hepatology Communications, vol. 8, no. 8, e0499. https://doi.org/10.1097/HC9.0000000000000499
Cuthbertson, DJ, Keating, SE, Pugh, CJA, Owen, PJ, Kemp, GJ, Umpleby, M, Geyer, NG, Chinchilli, VM & Stine, JG 2024, 'Exercise improves surrogate measures of liver histological response in metabolic dysfunction-associated steatotic liver disease', Liver International, vol. 44, no. 9, pp. 2368-2381. https://doi.org/10.1111/liv.15947
Harris, SJ & Stine, JG 2024, 'Frailty in liver transplantation: Exploring prescribing exercise as medicine to improve patient outcomes', Liver International, vol. 44, no. 9, pp. 2251-2262. https://doi.org/10.1111/liv.15986
Stine, JG & Henry, ZH 2024, 'How to Write an Exercise Prescription to Treat Metabolic Dysfunction-Associated Steatotic Liver Disease for the Busy Clinician', American Journal of Gastroenterology, vol. 119, no. 6, pp. 1007-1010. https://doi.org/10.14309/ajg.0000000000002805
Stine, JG, Medic, N, Pettersson, B, Venerus, M & Blau, JE 2024, 'The health care experience of adults with metabolic dysfunction–associated steatohepatitis and influence of PNPLA3: A qualitative study', Hepatology Communications, vol. 8, no. 6, e0451. https://doi.org/10.1097/HC9.0000000000000451
Faust, AJ & Stine, JG 2024, 'Unlocking metabolic flexibility: Is this the key to preventing weight gain in liver transplant recipients?', Liver Transplantation, vol. 30, no. 2, pp. 119-121. https://doi.org/10.1097/LVT.0000000000000224
Barritt, AS & Stine, JG 2025, 'Update on Newly Federal Drug Administration-Approved Drug, Resmetirom: A Practical Perspective', American Journal of Gastroenterology, vol. 120, no. 2, pp. 272-276. https://doi.org/10.14309/ajg.0000000000002922
2023
Healthy Livers, Healthy Lives Collaborators 2024, 'A global action agenda for turning the tide on fatty liver disease', Hepatology, vol. 79, no. 2, pp. 502-523. https://doi.org/10.1097/HEP.0000000000000545
Healthy Livers, Healthy Lives Collaborators 2023, 'A global research priority agenda to advance public health responses to fatty liver disease', Journal of Hepatology, vol. 79, no. 3, pp. 618-634. https://doi.org/10.1016/j.jhep.2023.04.035
Stine, JG, Long, MT, Corey, KE, Sallis, RE, Allen, AM, Armstrong, MJ, Conroy, DE, Cuthbertson, DJ, Duarte-Rojo, A, Hallsworth, K, Hickman, IJ, Kappus, MR, Keating, SE, Pugh, CJA, Rotman, Y, Simon, TG, Vilar-Gomez, E, Wong, VWS & Schmitz, KH 2023, 'American College of Sports Medicine (ACSM) International Multidisciplinary Roundtable report on physical activity and nonalcoholic fatty liver disease', Hepatology Communications, vol. 7, no. 4, e0108. https://doi.org/10.1097/HC9.0000000000000108
Heinle, JW, DiJoseph, K, Sabag, A, Oh, S, Kimball, SR, Keating, S & Stine, JG 2023, 'Exercise Is Medicine for Nonalcoholic Fatty Liver Disease: Exploration of Putative Mechanisms', Nutrients, vol. 15, no. 11, 2452. https://doi.org/10.3390/nu15112452
Stine, JG, Dijoseph, K, Pattison, Z, Harrington, A, Chinchilli, VM, Schmitz, KH & Loomba, R 2023, 'Exercise Training Is Associated With Treatment Response in Liver Fat Content by Magnetic Resonance Imaging Independent of Clinically Significant Body Weight Loss in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis', American Journal of Gastroenterology, vol. 118, no. 7, pp. 1204-1213. https://doi.org/10.14309/ajg.0000000000002098
Keating, SE, Sabag, A, Hallsworth, K, Hickman, IJ, Macdonald, GA, Stine, JG, George, J & Johnson, NA 2023, 'Exercise in the Management of Metabolic-Associated Fatty Liver Disease (MAFLD) in Adults: A Position Statement from Exercise and Sport Science Australia', Sports Medicine, vol. 53, no. 12, pp. 2347-2371. https://doi.org/10.1007/s40279-023-01918-w
Harris, SJ, Smith, N, Hummer, B, Schreibman, IR, Faust, AJ, Geyer, NR, Chinchilli, VM, Sciamanna, C, Loomba, R & Stine, JG 2024, 'Exercise training improves serum biomarkers of liver fibroinflammation in patients with metabolic dysfunction-associated steatohepatitis', Liver International, vol. 44, no. 2, pp. 532-540. https://doi.org/10.1111/liv.15769
Bezinover, D, Alhkouri, N, Schumann, R, Geyer, N, Chinchilli, V & Stine, JG 2023, 'Liver Transplant Outcomes in Young Adults with Cirrhosis Related to Nonalcoholic Fatty Liver Disease', Transplantation proceedings, vol. 55, no. 9, pp. 2134-2142. https://doi.org/10.1016/j.transproceed.2023.08.020
Stine, JG, Rivas, G, Hummer, B, Duarte-Rojo, A, May, CN, Geyer, N, Chinchilli, VM, Conroy, DE, Mitchell, ES, McCallum, M, Michealides, A & Schmitz, KH 2023, 'Mobile health lifestyle intervention program leads to clinically significant loss of body weight in patients with NASH', Hepatology Communications, vol. 7, no. 4, e0052. https://doi.org/10.1097/HC9.0000000000000052
Dahmus, J, Hummer, B, Rivas, G, Schmitz, K, Caldwell, SH, Argo, CK, Schreibman, I & Stine, JG 2023, 'Patients with Nonalcoholic Steatohepatitis and Advanced Liver Disease Have the Lowest Cardiorespiratory Fitness', Digestive Diseases and Sciences, vol. 68, no. 6, pp. 2695-2703. https://doi.org/10.1007/s10620-022-07809-w
Stine, JG, Long, MT, Corey, KE, Sallis, RE, Allen, AM, Armstrong, MJ, Conroy, DE, Cuthbertson, DJ, Duarte-Rojo, A, Hallsworth, K, Hickman, IJ, Kappus, MR, Keating, SE, Pugh, CJA, Rotman, Y, Simon, TL, Vilar-Gomez, E, Wong, VWS & Schmitz, KH 2023, 'Physical Activity and Nonalcoholic Fatty Liver Disease: A Roundtable Statement from the American College of Sports Medicine', Medicine and science in sports and exercise, vol. 55, no. 9, pp. 1717-1726. https://doi.org/10.1249/MSS.0000000000003199
Intagliata, NM, Rahimi, RS, Higuera-de-la-Tijera, F, Simonetto, DA, Farias, AQ, Mazo, DF, Boike, JR, Stine, JG, Serper, M, Pereira, G, Mattos, AZ, Marciano, S, Davis, JPE, Benitez, C, Chadha, R, Méndez-Sánchez, N, deLemos, AS, Mohanty, A, Dirchwolf, M, Fortune, BE, Northup, PG, Patrie, JT & Caldwell, SH 2023, 'Procedural-Related Bleeding in Hospitalized Patients With Liver Disease (PROC-BLeeD): An International, Prospective, Multicenter Observational Study', Gastroenterology, vol. 165, no. 3, pp. 717-732. https://doi.org/10.1053/j.gastro.2023.05.046
Stine, JG, Welles, JE, Keating, S, Hussaini, Z, Soriano, C, Heinle, JW, Geyer, N, Chinchilli, VM, Loomba, R & Kimball, SR 2023, 'Serum Fibroblast Growth Factor 21 Is Markedly Decreased following Exercise Training in Patients with Biopsy-Proven Nonalcoholic Steatohepatitis', Nutrients, vol. 15, no. 6, 1481. https://doi.org/10.3390/nu15061481
Stine, JG & Romeo, S 2023, 'Sweating it out: How physical activity can combat high genetic risk for nonalcoholic fatty liver disease', Liver International, vol. 43, no. 8, pp. 1623-1625. https://doi.org/10.1111/liv.15642
Duarte-Rojo, A, Bloomer, PM, Grubbs, RK, Stine, JG, Ladner, D, Hughes, CB, Dunn, MA & Jakicic, JM 2023, 'Use of a Mobile-Assisted Telehealth Regimen to Increase Exercise in Transplant Candidates: A Home-Based Prehabilitation Pilot and Feasibility Trial', Clinical and Translational Gastroenterology, vol. 14, no. 11, pp. e00601. https://doi.org/10.14309/ctg.0000000000000601
2022
Collins, SL, Stine, JG, Bisanz, JE, Okafor, CD & Patterson, AD 2023, 'Bile acids and the gut microbiota: metabolic interactions and impacts on disease', Nature Reviews Microbiology, vol. 21, no. 4, pp. 236-247. https://doi.org/10.1038/s41579-022-00805-x
Drug-Induced Liver Injury Network (DILIN) Study Investigators 2022, 'Clinical characteristics of antiepileptic-induced liver injury in patients from the DILIN prospective study', Journal of Hepatology, vol. 76, no. 4, pp. 832-840. https://doi.org/10.1016/j.jhep.2021.12.013
Stine, JG & Loomba, R 2022, 'Magnetic resonance imaging proton density fat fraction as an imaging-based biomarker of treatment response in patients with nonalcoholic steatohepatitis', Clinical Liver Disease, vol. 20, no. 6, pp. 198-201. https://doi.org/10.1002/cld.1249
Stine, JG, Schreibman, IR, Faust, AJ, Dahmus, J, Stern, B, Soriano, C, Rivas, G, Hummer, B, Kimball, SR, Geyer, NR, Chinchilli, VM, Loomba, R, Schmitz, K, Sciamanna, C, Strine, C, Wentzel, R, Marlin, S, Sica, C, Vesek, J, Eyster, E, Sinoway, L, Bentz, K, Handley, N, Hershey Fell, B, Mottilla, S, Christ, C, George, S, Novchich, T, Beyer, M, Clarke, K, Myers, T, Glading-Steinruck, M, Krok, K, Ma, T, Riley, T, Thompson, E, Tressler, H, Broach, J, Doan, T, Patrick, S, Reed, S, Hamilton, C, Slavoski, K & Tregea, D 2022, 'NASHFit: A randomized controlled trial of an exercise training program to reduce clotting risk in patients with NASH', Hepatology, vol. 76, no. 1, pp. 172-185. https://doi.org/10.1002/hep.32274
DiJoseph, K, Thorp, A, Harrington, A, Schmitz, KH, Chinchilli, VM & Stine, JG 2023, 'Physical Activity and Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis', Digestive Diseases and Sciences, vol. 68, no. 3, pp. 1051-1059. https://doi.org/10.1007/s10620-022-07601-w
Clarke, K, DiJoseph, K, White, R, Yaghnam, I, Lee, R & Stine, JG 2022, 'Post-polypectomy follow-up recommendations by practicing academic gastroenterologists—does number of years in practice matter?', International Journal of Colorectal Disease, vol. 37, no. 4, pp. 979-982. https://doi.org/10.1007/s00384-022-04120-y
Stine, JG, Schreibman, IR, Faust, AJ, Dahmus, J, Stern, B, Soriano, C, Rivas, G, Hummer, B, Kimball, SR, Geyer, NR, Chinchilli, VM, Schmitz, K & Sciamanna, C 2022, 'Reply', Hepatology, vol. 76, no. 1, pp. E18-E19. https://doi.org/10.1002/hep.32390
Jain, A, Haussner, D, Hranjec, T, Butt, FK, Stine, JG, Ankola, A, Al Yousif, H, Dicristina, R, Krok, KL & Arenas, J 2022, 'Review of Sarcopenia and Testosterone Deficiency With Chronic Liver Disease and Postoperative Liver Transplant Utility of Short-Term Testosterone Replacement Therapy', Experimental and Clinical Transplantation, vol. 20, no. 11, pp. 1000-1008. https://doi.org/10.6002/ect.2022.0132
2021
Bezinover, D, Geyer, NR, Dahmus, J, Chinchilli, VM & Stine, JG 2022, 'A decline in functional status while awaiting liver transplantation is predictive of increased post-transplantation mortality', HPB, vol. 24, no. 6, pp. 825-832. https://doi.org/10.1016/j.hpb.2021.10.008
Intagliata, NM, Davitkov, P, Allen, AM, Falck-Ytter, YT & Stine, JG 2021, 'AGA Technical Review on Coagulation in Cirrhosis', Gastroenterology, vol. 161, no. 5, pp. 1630-1656. https://doi.org/10.1053/j.gastro.2021.09.004
Stine, JG, Munaganuru, N, Barnard, A, Wang, JL, Kaulback, K, Argo, CK, Singh, S, Fowler, KJ, Sirlin, CB & Loomba, R 2021, 'Change in MRI-PDFF and Histologic Response in Patients With Nonalcoholic Steatohepatitis: A Systematic Review and Meta-Analysis', Clinical Gastroenterology and Hepatology, vol. 19, no. 11, pp. 2274-2283.e5. https://doi.org/10.1016/j.cgh.2020.08.061
Kadry, Z, Schaefer, E, Krok, K, Faust, A, Stine, JG, Schreibman, IR, Bezinover, D & Riley, TR 2021, 'Excellent outcomes with liver transplantation in hepatopulmonary syndrome across pre-transplant PaO2 spectrum', JHEP Reports, vol. 3, no. 5, 100351. https://doi.org/10.1016/j.jhepr.2021.100351
Hughes, A, Dahmus, J, Rivas, G, Hummer, B, Chen See, JR, Wright, JR, Lamendella, R, Schmitz, KH, Sciamanna, C, Ruffin, M, Patterson, AD, Loomba, R & Stine, JG 2021, 'Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study', Clinical Gastroenterology and Hepatology, vol. 19, no. 8, pp. 1723-1725. https://doi.org/10.1016/j.cgh.2020.08.063
Faust, A & Stine, JG 2021, 'Leveraging the Coronavirus Disease 2019 Pandemic: Is It Time to Consider Incorporating Mobile Applications Into Standard Clinical Management of the Liver Transplantation Patient?', Liver Transplantation, vol. 27, no. 4, pp. 479-481. https://doi.org/10.1002/lt.25991
Sharma, S, Stine, JG, Verbeek, T & Bezinover, D 2022, 'Management of Patients With Non-alcoholic Steatohepatitis Undergoing Liver Transplantation: Considerations for the Anesthesiologist', Journal of cardiothoracic and vascular anesthesia, vol. 36, no. 8, pp. 2616-2627. https://doi.org/10.1053/j.jvca.2021.07.020
Rivas, G, Hummer-Bair, B, Bezinover, D, Kadry, Z & Stine, J 2021, 'Plasminogen activator inhibitor is significantly elevated in liver transplant recipients with decompensated NASH cirrhosis', BMJ Open Gastroenterology, vol. 8, no. 1, e000683. https://doi.org/10.1136/bmjgast-2021-000683
Kadry, Z, Stine, JG, Dohi, T, Jain, A, Robyak, KL, Kwon, O, Hamilton, CJ, Janicki, P, Riley, TR, Butt, F, Krok, K, Schreibman, IR, Bezinover, D, Ghahramani, N, Campos, S & Hollenbeak, CS 2021, 'Renal Protective Effect of Everolimus in Liver Transplantation: A Prospective Randomized Open-Label Trial', Transplantation Direct, vol. 7, no. 7, pp. E709. https://doi.org/10.1097/TXD.0000000000001159
Niccum, BA, Stine, JG, Wynter, JA, Kelly, V, Caldwell, SH & Shah, NL 2021, 'Success of direct-acting, antiviral-based therapy for chronic hepatitis C is not affected by type 2 diabetes', Clinical Diabetes, vol. 38, no. 1, pp. 40-46. https://doi.org/10.2337/cd18-0112
Faust, A & Stine, JG 2022, 'Time to Step It Up: Mobile Health Intervention for Lifestyle Modification in Patients with Nonalcoholic Fatty Liver Disease', Digestive Diseases and Sciences, vol. 67, no. 2, pp. 403-405. https://doi.org/10.1007/s10620-021-07018-x
Motz, V, Faust, A, Dahmus, J, Stern, B, Soriano, C & Stine, JG 2021, 'Utilization of a directly supervised telehealth-based exercise training program in patients with nonalcoholic steatohepatitis: Feasibility study', JMIR Formative Research, vol. 5, no. 8, e30239. https://doi.org/10.2196/30239
Ladwig, MA, Sciamanna, CN, Auer, BJ, Oser, TK, Stine, JG & Agans, JP 2021, 'When American adults do move, how do they do so? Trends in physical activity intensity, type, and modality: 1988-2017', Journal of Physical Activity and Health, vol. 18, no. 10, pp. 1181-1198. https://doi.org/10.1123/jpah.2020-0424