Researcher Profile
Researcher Profile
Jonathan Stine, MD, MSc
Assistant Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Assistant Professor, Department of Public Health Sciences
Division of Gastroenterology and Hepatology
Assistant Professor, Department of Public Health Sciences
Scientific Program:Cancer Control
Research Interests
Dr. Jonathan Stine's clinical and research areas of expertise include NAFLD, coagulation disorders in chronic liver disease, drug-induced liver injury (DILI) and liver transplantation.
The majority of his early work focused on DILI in both the population at large, as well as in special populations, including the elderly and patients with underlying chronic liver disease including cirrhosis.
His more recent work has focused on liver transplantation coagulation disorders and outcomes-based research in which the link between pre- and post-transplantation vascular events was demonstrated.
Additionally, Dr. Stine and his research group found that despite broader organ-sharing policies, geographic disparities persist and regional access to liver transplantation remains highly variable and inequitable.
Dr. Stine is the principal investigator on the NASHFit Trial and is continuing forward his work on the hypercoagulable environment in NASH patients, where he previously demonstrated that NASH increases one's risk of venous thromboembolic disease.
Dr. Stine serves as the Director of Research for Penn State Liver Center.
- Liver
- Fibrosis
- Thrombosis
- Portal Vein
- Non-alcoholic Fatty Liver Disease
- Therapeutics
- Chemical and Drug Induced Liver Injury
- Liver Transplantation
- Transplants
- Liver Diseases
- Pharmaceutical Preparations
- Systematic Reviews
Recent Publications
2021
Stine, JG, Munaganuru, N, Barnard, A, Wang, JL, Kaulback, K, Argo, CK, Singh, S, Fowler, KJ, Sirlin, CB & Loomba, R 2021, 'Change in MRI-PDFF and Histologic Response in Patients With Nonalcoholic Steatohepatitis: A Systematic Review and Meta-Analysis', Clinical Gastroenterology and Hepatology. https://doi.org/10.1016/j.cgh.2020.08.061
Hughes, A, Dahmus, J, Rivas, G, Hummer, B, Chen See, JR, Wright, JR, Lamendella, R, Schmitz, KH, Sciamanna, C, Ruffin, M, Patterson, AD, Loomba, R & Stine, JG 2021, 'Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study', Clinical Gastroenterology and Hepatology. https://doi.org/10.1016/j.cgh.2020.08.063
Faust, A & Stine, JG 2021, 'Leveraging the Coronavirus Disease 2019 Pandemic: Is It Time to Consider Incorporating Mobile Applications Into Standard Clinical Management of the Liver Transplantation Patient?', Liver Transplantation, vol. 27, no. 4, pp. 479-481. https://doi.org/10.1002/lt.25991
Niccum, BA, Stine, JG, Wynter, JA, Kelly, V, Caldwell, SH & Shah, NL 2021, 'Success of direct-acting, antiviral-based therapy for chronic hepatitis C is not affected by type 2 diabetes', Clinical Diabetes, vol. 38, no. 1, pp. 40-46. https://doi.org/10.2337/cd18-0112
Faust, A & Stine, JG 2021, 'Time to Step It Up: Mobile Health Intervention for Lifestyle Modification in Patients with Nonalcoholic Fatty Liver Disease', Digestive Diseases and Sciences. https://doi.org/10.1007/s10620-021-07018-x
2020
Stine, JG, Soriano, C, Schreibman, I, Rivas, G, Hummer, B, Yoo, E, Schmitz, K & Sciamanna, C 2020, 'Breaking Down Barriers to Physical Activity in Patients with Nonalcoholic Fatty Liver Disease', Digestive Diseases and Sciences. https://doi.org/10.1007/s10620-020-06673-w
Clarke, K, Kang, M, Gorrepati, VS, Stine, JG, Tinsley, A, Williams, E, Moyer, M & Coates, M 2020, 'Dysplasia detection is similar between chromoendoscopy and high-definition white-light colonoscopy in inflammatory bowel disease patients: a US-matched case-control study', International Journal of Colorectal Disease, vol. 35, no. 12, pp. 2301-2307. https://doi.org/10.1007/s00384-020-03719-3
Mellinger, JL & Stine, JG 2020, 'Early Liver Transplantation for Severe Alcoholic Hepatitis', Digestive Diseases and Sciences, vol. 65, no. 6, pp. 1608-1614. https://doi.org/10.1007/s10620-020-06159-9
Stine, JG, Xu, D, Schmitz, K, Sciamanna, C & Kimball, SR 2020, 'Exercise Attenuates Ribosomal Protein Six Phosphorylation in Fatty Liver Disease', Digestive Diseases and Sciences, vol. 65, no. 11, pp. 3238-3243. https://doi.org/10.1007/s10620-020-06226-1
Bezinover, D, Nahouraii, L, Sviatchenko, A, Wang, M, Kimatian, S, Saner, FH & Stine, JG 2020, 'Hyponatremia is associated with increased mortality in children on the waiting list for liver transplantation', Transplantation Direct. <https://journals.lww.com/transplantationdirect/Fulltext/2020/10000/Hyponatremia_Is_Associated_With_Increased.4.aspx>
Spinosa, M & Stine, JG 2020, 'Nonalcoholic fatty liver disease-evidence for a thrombophilic state?', Current Pharmaceutical Design, vol. 26, no. 10, pp. 1036-1044. https://doi.org/10.2174/1381612826666200131101553
Stine, JG, Schreibman, I, Navabi, S, Kang, M, Dahmus, J, Soriano, C, Rivas, G, Hummer, B, Beyer, M, Tressler, H, Kimball, SR, Patterson, AD, Schmitz, K & Sciamanna, C 2020, 'Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH', Contemporary Clinical Trials Communications, vol. 18, 100560. https://doi.org/10.1016/j.conctc.2020.100560
Verbeek, TA, Stine, JG, Saner, FH & Bezinover, D 2020, 'Osmotic demyelination syndrome: are patients with end-stage liver disease a special risk group?', Minerva anestesiologica, vol. 86, no. 7, pp. 756-767. https://doi.org/10.23736/S0375-9393.20.14120-8
2019
Stine, JG, Intagliata, NM, Shah, NL, Lisman, T, Violi, F, Caldwell, SH & Argo, CK 2020, 'Clinical Cirrhosis Dilemmas: Survey of Practice from the 7th International Coagulation in Liver Disease Conference', Digestive Diseases and Sciences, vol. 65, no. 5, pp. 1334-1339. https://doi.org/10.1007/s10620-019-05884-0
Stine, J 2019, 'Concise Commentary: The Clot Thickens—Why Pylephlebitis Is One of the Most Feared Complications of Intra-abdominal Sepsis', Digestive Diseases and Sciences, vol. 64, no. 6, pp. 1722-1723. https://doi.org/10.1007/s10620-018-5440-6
Gaballa, D, Bezinover, D, Kadry, Z, Eyster, E, Wang, M, Northup, PG & Stine, JG 2019, 'Development of a Model to Predict Portal Vein Thrombosis in Liver Transplant Candidates: The Portal Vein Thrombosis Risk Index', Liver Transplantation, vol. 25, no. 12, pp. 1747-1755. https://doi.org/10.1002/lt.25630
Bezinover, D, Navabi, S, Wang, M, Li, Z, William, M & Stine, JG 2019, 'Hyponatremia Is Protective Against the Development of Portal Vein Thrombosis in Patients Undergoing Liver Transplant', Transplantation proceedings, vol. 51, no. 6, pp. 1880-1886. https://doi.org/10.1016/j.transproceed.2019.05.014
Ma, S, Wang, J, Bezinover, D, Kadry, Z, Northrup, P & Stine, J 2019, 'Inherited thrombophilia and portal vein thrombosis in cirrhosis: A systematic review and meta‐analysis', Research and Practice in Thrombosis and Haemostasis, vol. 3, no. 4, pp. 658-667. <https://onlinelibrary.wiley.com/doi/full/10.1002/rth2.12253>
Stine, JG 2020, 'I’m a Junior Faculty Member at an Academic Medical Center…Now What?', Digestive Diseases and Sciences, vol. 65, no. 1, pp. 15-17. https://doi.org/10.1007/s10620-019-05946-3
Stine, JG, Stukenborg, GJ, Wang, J, Adkins, A, Niccum, B, Zimmet, A & Argo, CK 2020, 'Liver transplant candidates have impaired quality of life across health domains as assessed by computerized testing', Annals of Hepatology, vol. 19, no. 1, pp. 62-68. https://doi.org/10.1016/j.aohep.2019.06.018
Shenoy, A, Stine, JG & Intagliata, NM 2019, 'Venous thromboembolism in patients with liver diseases: comment', Journal of Thrombosis and Haemostasis, vol. 17, no. 1, pp. 238-239. https://doi.org/10.1111/jth.14320
2018
Intagliata, NM, Argo, CK, Stine, JG, Lisman, T, Caldwell, SH & Violi, F 2018, 'Concepts and Controversies in Haemostasis and Thrombosis Associated with Liver Disease: Proceedings of the 7th International Coagulation in Liver Disease Conference', Thrombosis and Haemostasis, vol. 118, no. 8, pp. 1491-1506. https://doi.org/10.1055/s-0038-1666861
Stine, JG, Bezinover, D & Kadry, Z 2018, 'Coronary artery disease in decompensated patients undergoing liver transplantation evaluation', Liver Transplantation, vol. 24, no. 7, pp. 976-977. https://doi.org/10.1002/lt.25064
Stine, JG, Wang, J, Shah, PM, Argo, CK, Intagliata, N, Uflacker, A, Caldwell, SH & Northup, PG 2018, 'Decreased portal vein velocity is predictive of the development of portal vein thrombosis: A matched case-control study', Liver International, vol. 38, no. 1, pp. 94-101. https://doi.org/10.1111/liv.13500
Stine, JG, Northup, PG, Stukenborg, GJ, Cornella, SL, Maluf, DG, Pelletier, SJ & Argo, CK 2018, 'Geographic variation in liver transplantation persists despite implementation of Share35', Hepatology Research, vol. 48, no. 4, pp. 225-232. https://doi.org/10.1111/hepr.12922
Kaps, L, Stine, J, Mellinger, JL & Vilarinho, S 2018, 'Great expectations: Principal investigator and trainee perspectives on hiring, supervision, and mentoring', Hepatology Communications, vol. 2, no. 9, pp. 999-1004. <https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep4.1205>
Verbeek, TA, Stine, JG, Saner, FH & Bezinover, D 2018, 'Hypercoagulability in end-stage liver disease: Review of epidemiology, etiology, and management', Transplantation Direct, vol. 4, no. 11, e401. https://doi.org/10.1097/TXD.0000000000000843
Stine, JG, Niccum, BA, Zimmet, AN, Intagliata, N, Caldwell, SH, Argo, CK & Northup, PG 2018, 'Increased risk of venous thromboembolism in hospitalized patients with cirrhosis due to non-alcoholic steatohepatitis original-contribution', Clinical and Translational Gastroenterology, vol. 9, no. 3, 140. https://doi.org/10.1038/s41424-018-0002-y
Stine, J & Northup, PG 2019, 'Management of Non-tumoral Portal Vein Thrombosis in Patients with Cirrhosis', Digestive Diseases and Sciences, vol. 64, no. 3, pp. 619-626. https://doi.org/10.1007/s10620-018-5427-3
Bezinover, D, Deacutis, MF, Dalal, P, Moore, RP, Stine, J, Wang, M, Reeder, E, Hollenbeak, CS, Saner, FH, Riley III, T & Janicki, P 2019, 'Perioperative thrombotic complications associated with pediatric liver transplantation: a UNOS database evaluation', HPB, vol. 21, no. 3, pp. 370-378. https://doi.org/10.1016/j.hpb.2018.08.014
Argo, CK, Stine, J, Henry, ZH, Lackner, C, Patrie, JT, Weltman, AL & Caldwell, SH 2018, 'Physical deconditioning is the common denominator in both obese and overweight subjects with nonalcoholic steatohepatitis', Alimentary Pharmacology and Therapeutics, vol. 48, no. 3, pp. 290-299. https://doi.org/10.1111/apt.14803
Stine, JG, Prakash, S & Northup, PG 2018, 'Portal vein thrombosis after hepatitis C eradication with direct acting antiviral therapy', Liver International, vol. 38, no. 1, pp. 185-186. https://doi.org/10.1111/liv.13537
Stine, JG, Wentworth, BJ, Zimmet, A, Rinella, ME, Loomba, R, Caldwell, SH & Argo, CK 2018, 'Systematic review with meta-analysis: risk of hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis compared to other liver diseases', Alimentary Pharmacology and Therapeutics, vol. 48, no. 7, pp. 696-703. https://doi.org/10.1111/apt.14937
Stine, JG, Wang, J, Cornella, SL, Behm, BW, Henry, Z, Shah, NL, Caldwell, SH & Northup, PG 2018, 'Treatment of type-1 hepatorenal syndrome with pentoxifylline: A randomized placebo controlled clinical trial', Annals of Hepatology, vol. 17, no. 2, pp. 300-306. https://doi.org/10.5604/01.3001.0010.8660
Buckholz, A, Orton, C, Stine, J, Moskaluk, CA & Powell, S 2018, 'Universal Immunohistochemistry Screening for Lynch Syndrome: Real World Lessons from an Academic Institutional Experience', Current Trends in Internal Medicine. <https://www.gavinpublishers.com/articles/research-article/Current-trends-in-Internal-Medicine/universal-immunohistochemistry-screening-for-lynch-syndrome-real-world-lessons-from-an-academic-institutional-experience>
2017
Stine, JG, Argo, CK, Pelletier, SJ, Maluf, DG, Caldwell, SH & Northup, PG 2017, 'Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis', World Journal of Hepatology, vol. 9, no. 3, pp. 139-146. https://doi.org/10.4254/wjh.v9.i3.139
Stine, JG & Northup, PG 2017, 'Coagulopathy Before and After Liver Transplantation: From the Hepatic to the Systemic Circulatory Systems', Clinics in Liver Disease, vol. 21, no. 2, pp. 253-274. https://doi.org/10.1016/j.cld.2016.12.003
Stine, JG & Chalasani, NP 2017, 'Drug Hepatotoxicity: Environmental Factors', Clinics in Liver Disease, vol. 21, no. 1, pp. 103-113. https://doi.org/10.1016/j.cld.2016.08.008
Stine, JG & Rinella, ME 2017, 'Editorial: Age and Non-Invasive Markers of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease: Time to Adjust the Clock?', American Journal of Gastroenterology, vol. 112, no. 5, pp. 752-754. https://doi.org/10.1038/ajg.2017.60
Stine, JG, Wynter, JA, Niccum, B, Kelly, V, Caldwell, SH & Shah, NL 2017, 'Effect of treatment with direct acting antiviral on glycemic control in patients with diabetes mellitus and chronic hepatitis C', Annals of Hepatology, vol. 16, no. 2, pp. 215-220. https://doi.org/10.5604/16652681.1231579
Stine, JG, Intagliata, N, Northup, PG & Caldwell, SH 2017, 'Nonalcoholic Fatty Liver Disease, Portal Vein Thrombosis and Coagulation: More Questions Than Answers?', Transplantation, vol. 101, no. 8, pp. e281-e282. https://doi.org/10.1097/TP.0000000000001807
Stine, JG, Wynter, JA, Niccum, B, Kelly, V, Caldwell, SH & Shah, NL 2017, 'Reply to “HbA1c levels as a parameter of glycemic control in patients with liver cirrhosis”', Annals of Hepatology, vol. 16, no. 3, pp. 471-472. https://doi.org/10.5604/16652681.1235497
Myc, LA, Stine, JG, Chakrapani, R, Kadl, A & Argo, CK 2017, 'Vasopressin use in critically ill cirrhosis patients with catecholamine-resistant septic shock: The CVICU cohort', World Journal of Hepatology, vol. 9, no. 2, pp. 106-113. https://doi.org/10.4254/wjh.v9.i2.106