Navigation Menu

Clinical Trial External Search

Children (age < 18 years)
Adults (age >= 18 years)

Researcher Profile

Researcher Display

Jonathan Stine, MD, MSc

Jonathan Stine, MD, MSc

Associate Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Associate Professor, Department of Public Health Sciences
Scientific Program:Cancer Control

Research Interests

Dr. Jonathan Stine is an internationally recognized liver expert with a research and clinical focus on nonalcoholic fatty liver disease and exercise. He has authored more than 70 peer-reviewed papers, including multinational consensus guidelines, and several book chapters.

Stine is the recipient of multiple research grants and awards from the American Association for the Study of Liver Diseases, American Cancer Society and National Institutes of Health. He has been a study investigator on more than 20 nonalcoholic fatty liver disease clinical trials and is on the editorial board for several leading hepatology journals.

In addition to his scholarly work, Stine is research director for Penn State Health Liver Center. He is also a core faculty member of The ONE Group (Oncology - Nutrition - Exercise).

  • Liver Transplantation
  • Fibrosis
  • Thrombosis
  • Non-alcoholic Fatty Liver Disease
  • Portal Vein
  • Liver
  • Therapeutics
  • Exercise
  • Chemical and Drug Induced Liver Injury
  • Liver Diseases
  • Systematic Reviews
  • Mortality

Recent Publications


Healthy Livers, Healthy Lives Collaborators 2023, 'A global research priority agenda to advance public health responses to fatty liver disease', Journal of Hepatology, vol. 79, no. 3, pp. 618-634.
Heinle, JW, DiJoseph, K, Sabag, A, Oh, S, Kimball, SR, Keating, S & Stine, JG 2023, 'Exercise Is Medicine for Nonalcoholic Fatty Liver Disease: Exploration of Putative Mechanisms', Nutrients, vol. 15, no. 11, 2452.
Stine, JG, Dijoseph, K, Pattison, Z, Harrington, A, Chinchilli, VM, Schmitz, KH & Loomba, R 2023, 'Exercise Training Is Associated With Treatment Response in Liver Fat Content by Magnetic Resonance Imaging Independent of Clinically Significant Body Weight Loss in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis', American Journal of Gastroenterology, vol. 118, no. 7, pp. 1204-1213.
Keating, SE, Sabag, A, Hallsworth, K, Hickman, IJ, Macdonald, GA, Stine, JG, George, J & Johnson, NA 2023, 'Exercise in the Management of Metabolic-Associated Fatty Liver Disease (MAFLD) in Adults: A Position Statement from Exercise and Sport Science Australia', Sports Medicine.
Bezinover, D, Alhkouri, N, Schumann, R, Geyer, N, Chinchilli, V & Stine, J 2023, 'Liver Transplant Outcomes in Young Adults with Cirrhosis Related to Nonalcoholic Fatty Liver Disease', Transplantation proceedings.
Dahmus, J, Hummer, B, Rivas, G, Schmitz, K, Caldwell, SH, Argo, CK, Schreibman, I & Stine, JG 2023, 'Patients with Nonalcoholic Steatohepatitis and Advanced Liver Disease Have the Lowest Cardiorespiratory Fitness', Digestive Diseases and Sciences, vol. 68, no. 6, pp. 2695-2703.
Stine, JG, Long, MT, Corey, KE, Sallis, RE, Allen, AM, Armstrong, MJ, Conroy, DE, Cuthbertson, DJ, Duarte-Rojo, A, Hallsworth, K, Hickman, IJ, Kappus, MR, Keating, SE, Pugh, CJA, Rotman, Y, Simon, TL, Vilar-Gomez, E, Wong, VWS & Schmitz, KH 2023, 'Physical Activity and Nonalcoholic Fatty Liver Disease: A Roundtable Statement from the American College of Sports Medicine', Medicine and science in sports and exercise, vol. 55, no. 9, pp. 1717-1726.
Intagliata, NM, Rahimi, RS, Higuera-de-la-Tijera, F, Simonetto, DA, Farias, AQ, Mazo, DF, Boike, JR, Stine, JG, Serper, M, Pereira, G, Mattos, AZ, Marciano, S, Davis, JPE, Benitez, C, Chadha, R, Méndez-Sánchez, N, deLemos, AS, Mohanty, A, Dirchwolf, M, Fortune, BE, Northup, PG, Patrie, JT & Caldwell, SH 2023, 'Procedural-Related Bleeding in Hospitalized Patients With Liver Disease (PROC-BLeeD): An International, Prospective, Multicenter Observational Study', Gastroenterology, vol. 165, no. 3, pp. 717-732.
Stine, JG, Welles, JE, Keating, S, Hussaini, Z, Soriano, C, Heinle, JW, Geyer, N, Chinchilli, VM, Loomba, R & Kimball, SR 2023, 'Serum Fibroblast Growth Factor 21 Is Markedly Decreased following Exercise Training in Patients with Biopsy-Proven Nonalcoholic Steatohepatitis', Nutrients, vol. 15, no. 6, 1481.
Stine, JG & Romeo, S 2023, 'Sweating it out: How physical activity can combat high genetic risk for nonalcoholic fatty liver disease', Liver International, vol. 43, no. 8, pp. 1623-1625.


Collins, SL, Stine, JG, Bisanz, JE, Okafor, CD & Patterson, AD 2023, 'Bile acids and the gut microbiota: metabolic interactions and impacts on disease', Nature Reviews Microbiology, vol. 21, no. 4, pp. 236-247.
Drug-Induced Liver Injury Network (DILIN) Study Investigators 2022, 'Clinical characteristics of antiepileptic-induced liver injury in patients from the DILIN prospective study', Journal of Hepatology, vol. 76, no. 4, pp. 832-840.
Stine, JG & Loomba, R 2022, 'Magnetic resonance imaging proton density fat fraction as an imaging-based biomarker of treatment response in patients with nonalcoholic steatohepatitis', Clinical Liver Disease, vol. 20, no. 6, pp. 198-201.
Stine, JG, Schreibman, IR, Faust, AJ, Dahmus, J, Stern, B, Soriano, C, Rivas, G, Hummer, B, Kimball, SR, Geyer, NR, Chinchilli, VM, Loomba, R, Schmitz, K, Sciamanna, C, Strine, C, Wentzel, R, Marlin, S, Sica, C, Vesek, J, Eyster, E, Sinoway, L, Bentz, K, Handley, N, Hershey Fell, B, Mottilla, S, Christ, C, George, S, Novchich, T, Beyer, M, Clarke, K, Myers, T, Glading-Steinruck, M, Krok, K, Ma, T, Riley, T, Thompson, E, Tressler, H, Broach, J, Doan, T, Patrick, S, Reed, S, Hamilton, C, Slavoski, K & Tregea, D 2022, 'NASHFit: A randomized controlled trial of an exercise training program to reduce clotting risk in patients with NASH', Hepatology, vol. 76, no. 1, pp. 172-185.
DiJoseph, K, Thorp, A, Harrington, A, Schmitz, KH, Chinchilli, VM & Stine, JG 2023, 'Physical Activity and Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis', Digestive Diseases and Sciences, vol. 68, no. 3, pp. 1051-1059.
Clarke, K, DiJoseph, K, White, R, Yaghnam, I, Lee, R & Stine, JG 2022, 'Post-polypectomy follow-up recommendations by practicing academic gastroenterologists—does number of years in practice matter?', International Journal of Colorectal Disease, vol. 37, no. 4, pp. 979-982.
Stine, JG, Schreibman, IR, Faust, AJ, Dahmus, J, Stern, B, Soriano, C, Rivas, G, Hummer, B, Kimball, SR, Geyer, NR, Chinchilli, VM, Schmitz, K & Sciamanna, C 2022, 'Reply', Hepatology, vol. 76, no. 1, pp. E18-E19.
Jain, A, Haussner, D, Hranjec, T, Butt, F, Stine, JG, Ankola, A, Al Yousif, H, Dicristina, R, Krok, KL & Arenas, J 2022, 'Review of Sarcopenia and Testosterone Deficiency With Chronic Liver Disease and Postoperative Liver Transplant Utility of Short-Term Testosterone Replacement Therapy', Experimental and Clinical Transplantation, vol. 20, no. 11, pp. 1000-1008.


Bezinover, D, Geyer, NR, Dahmus, J, Chinchilli, VM & Stine, JG 2022, 'A decline in functional status while awaiting liver transplantation is predictive of increased post-transplantation mortality', HPB, vol. 24, no. 6, pp. 825-832.
Intagliata, NM, Davitkov, P, Allen, AM, Falck-Ytter, YT & Stine, JG 2021, 'AGA Technical Review on Coagulation in Cirrhosis', Gastroenterology, vol. 161, no. 5, pp. 1630-1656.
Stine, JG, Munaganuru, N, Barnard, A, Wang, JL, Kaulback, K, Argo, CK, Singh, S, Fowler, KJ, Sirlin, CB & Loomba, R 2021, 'Change in MRI-PDFF and Histologic Response in Patients With Nonalcoholic Steatohepatitis: A Systematic Review and Meta-Analysis', Clinical Gastroenterology and Hepatology, vol. 19, no. 11, pp. 2274-2283.e5.
Kadry, Z, Schaefer, E, Krok, K, Faust, A, Stine, JG, Schreibman, IR, Bezinover, D & Riley, TR 2021, 'Excellent outcomes with liver transplantation in hepatopulmonary syndrome across pre-transplant PaO2 spectrum', JHEP Reports, vol. 3, no. 5, 100351.
Hughes, A, Dahmus, J, Rivas, G, Hummer, B, Chen See, JR, Wright, JR, Lamendella, R, Schmitz, KH, Sciamanna, C, Ruffin, M, Patterson, AD, Loomba, R & Stine, JG 2021, 'Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study', Clinical Gastroenterology and Hepatology, vol. 19, no. 8, pp. 1723-1725.
Faust, A & Stine, JG 2021, 'Leveraging the Coronavirus Disease 2019 Pandemic: Is It Time to Consider Incorporating Mobile Applications Into Standard Clinical Management of the Liver Transplantation Patient?', Liver Transplantation, vol. 27, no. 4, pp. 479-481.
Sharma, S, Stine, JG, Verbeek, T & Bezinover, D 2022, 'Management of Patients With Non-alcoholic Steatohepatitis Undergoing Liver Transplantation: Considerations for the Anesthesiologist', Journal of cardiothoracic and vascular anesthesia, vol. 36, no. 8, pp. 2616-2627.
Rivas, G, Hummer-Bair, B, Bezinover, D, Kadry, Z & Stine, J 2021, 'Plasminogen activator inhibitor is significantly elevated in liver transplant recipients with decompensated NASH cirrhosis', BMJ Open Gastroenterology, vol. 8, no. 1, e000683.
Kadry, Z, Stine, JG, Dohi, T, Jain, A, Robyak, KL, Kwon, O, Hamilton, CJ, Janicki, P, Riley, TR, Butt, F, Krok, K, Schreibman, IR, Bezinover, D, Ghahramani, N, Campos, S & Hollenbeak, CS 2021, 'Renal Protective Effect of Everolimus in Liver Transplantation: A Prospective Randomized Open-Label Trial', Transplantation Direct, vol. 7, no. 7, pp. E709.
Niccum, BA, Stine, JG, Wynter, JA, Kelly, V, Caldwell, SH & Shah, NL 2021, 'Success of direct-acting, antiviral-based therapy for chronic hepatitis C is not affected by type 2 diabetes', Clinical Diabetes, vol. 38, no. 1, pp. 40-46.
Faust, A & Stine, JG 2022, 'Time to Step It Up: Mobile Health Intervention for Lifestyle Modification in Patients with Nonalcoholic Fatty Liver Disease', Digestive Diseases and Sciences, vol. 67, no. 2, pp. 403-405.
Motz, V, Faust, A, Dahmus, J, Stern, B, Soriano, C & Stine, JG 2021, 'Utilization of a directly supervised telehealth-based exercise training program in patients with nonalcoholic steatohepatitis: Feasibility study', JMIR Formative Research, vol. 5, no. 8, e30239.
Ladwig, MA, Sciamanna, CN, Auer, BJ, Oser, TK, Stine, JG & Agans, JP 2021, 'When American adults do move, how do they do so? Trends in physical activity intensity, type, and modality: 1988-2017', Journal of Physical Activity and Health, vol. 18, no. 10, pp. 1181-1198.


Stine, JG, Soriano, C, Schreibman, I, Rivas, G, Hummer, B, Yoo, E, Schmitz, K & Sciamanna, C 2021, 'Breaking Down Barriers to Physical Activity in Patients with Nonalcoholic Fatty Liver Disease', Digestive Diseases and Sciences, vol. 66, no. 10, pp. 3604-3611.
Clarke, K, Kang, M, Gorrepati, VS, Stine, JG, Tinsley, A, Williams, E, Moyer, M & Coates, M 2020, 'Dysplasia detection is similar between chromoendoscopy and high-definition white-light colonoscopy in inflammatory bowel disease patients: a US-matched case-control study', International Journal of Colorectal Disease, vol. 35, no. 12, pp. 2301-2307.
Mellinger, JL & Stine, JG 2020, 'Early Liver Transplantation for Severe Alcoholic Hepatitis', Digestive Diseases and Sciences, vol. 65, no. 6, pp. 1608-1614.
Stine, JG, Xu, D, Schmitz, K, Sciamanna, C & Kimball, SR 2020, 'Exercise Attenuates Ribosomal Protein Six Phosphorylation in Fatty Liver Disease', Digestive Diseases and Sciences, vol. 65, no. 11, pp. 3238-3243.
Bezinover, D, Nahouraii, L, Sviatchenko, A, Wang, M, Kimatian, S, Saner, FH & Stine, JG 2020, 'Hyponatremia Is Associated With Increased Mortality in Children on the Waiting List for Liver Transplantation', Transplantation Direct, vol. 6, no. 10, pp. E604. <>
Spinosa, M & Stine, JG 2020, 'Nonalcoholic fatty liver disease-evidence for a thrombophilic state?', Current Pharmaceutical Design, vol. 26, no. 10, pp. 1036-1044.
Stine, JG, Schreibman, I, Navabi, S, Kang, M, Dahmus, J, Soriano, C, Rivas, G, Hummer, B, Beyer, M, Tressler, H, Kimball, SR, Patterson, AD, Schmitz, K & Sciamanna, C 2020, 'Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH', Contemporary Clinical Trials Communications, vol. 18, 100560.
Verbeek, TA, Stine, JG, Saner, FH & Bezinover, D 2020, 'Osmotic demyelination syndrome: are patients with end-stage liver disease a special risk group?', Minerva anestesiologica, vol. 86, no. 7, pp. 756-767.


Stine, JG, Intagliata, NM, Shah, NL, Lisman, T, Violi, F, Caldwell, SH & Argo, CK 2020, 'Clinical Cirrhosis Dilemmas: Survey of Practice from the 7th International Coagulation in Liver Disease Conference', Digestive Diseases and Sciences, vol. 65, no. 5, pp. 1334-1339.
Stine, J 2019, 'Concise Commentary: The Clot Thickens—Why Pylephlebitis Is One of the Most Feared Complications of Intra-abdominal Sepsis', Digestive Diseases and Sciences, vol. 64, no. 6, pp. 1722-1723.
Gaballa, D, Bezinover, D, Kadry, Z, Eyster, E, Wang, M, Northup, PG & Stine, JG 2019, 'Development of a Model to Predict Portal Vein Thrombosis in Liver Transplant Candidates: The Portal Vein Thrombosis Risk Index', Liver Transplantation, vol. 25, no. 12, pp. 1747-1755.
Bezinover, D, Navabi, S, Wang, M, Li, Z, William, M & Stine, JG 2019, 'Hyponatremia Is Protective Against the Development of Portal Vein Thrombosis in Patients Undergoing Liver Transplant', Transplantation proceedings, vol. 51, no. 6, pp. 1880-1886.
Ma, SD, Wang, J, Bezinover, D, Kadry, Z, Northup, PG & Stine, JG 2019, 'Inherited thrombophilia and portal vein thrombosis in cirrhosis: A systematic review and meta-analysis', Research and Practice in Thrombosis and Haemostasis, vol. 3, no. 4, pp. 658-667.
Ma, S, Wang, J, Bezinover, D, Kadry, Z, Northrup, P & Stine, J 2019, 'Inherited thrombophilia and portal vein thrombosis in cirrhosis: A systematic review and meta‐analysis', Research and Practice in Thrombosis and Haemostasis, vol. 3, no. 4, pp. 658-667. <>
Stine, JG 2020, 'I’m a Junior Faculty Member at an Academic Medical Center…Now What?', Digestive Diseases and Sciences, vol. 65, no. 1, pp. 15-17.
Stine, JG, Stukenborg, GJ, Wang, J, Adkins, A, Niccum, B, Zimmet, A & Argo, CK 2020, 'Liver transplant candidates have impaired quality of life across health domains as assessed by computerized testing', Annals of Hepatology, vol. 19, no. 1, pp. 62-68.
Shenoy, A, Stine, JG & Intagliata, NM 2019, 'Venous thromboembolism in patients with liver diseases: comment', Journal of Thrombosis and Haemostasis, vol. 17, no. 1, pp. 238-239.