Researcher Profile

Researcher Profile

Jonathan Stine, MD, MSc

Jonathan Stine, MD, MSc

Assistant Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Assistant Professor, Department of Public Health Sciences
Scientific Program:Cancer Control

Research Interests

Dr. Jonathan Stine's clinical and research areas of expertise include NAFLD, coagulation disorders in chronic liver disease, drug-induced liver injury (DILI) and liver transplantation.

The majority of his early work focused on DILI in both the population at large, as well as in special populations, including the elderly and patients with underlying chronic liver disease including cirrhosis.

His more recent work has focused on liver transplantation coagulation disorders and outcomes-based research in which the link between pre- and post-transplantation vascular events was demonstrated.

Additionally, Dr. Stine and his research group found that despite broader organ-sharing policies, geographic disparities persist and regional access to liver transplantation remains highly variable and inequitable.

Dr. Stine is the principal investigator on the NASHFit Trial and is continuing forward his work on the hypercoagulable environment in NASH patients, where he previously demonstrated that NASH increases one's risk of venous thromboembolic disease.

Dr. Stine serves as the Director of Research for Penn State Liver Center.

  • Liver
  • Fibrosis
  • Thrombosis
  • Portal Vein
  • Non-alcoholic Fatty Liver Disease
  • Therapeutics
  • Chemical and Drug Induced Liver Injury
  • Liver Transplantation
  • Transplants
  • Liver Diseases
  • Pharmaceutical Preparations
  • Systematic Reviews

Recent Publications


Stine, JG, Munaganuru, N, Barnard, A, Wang, JL, Kaulback, K, Argo, CK, Singh, S, Fowler, KJ, Sirlin, CB & Loomba, R 2021, 'Change in MRI-PDFF and Histologic Response in Patients With Nonalcoholic Steatohepatitis: A Systematic Review and Meta-Analysis', Clinical Gastroenterology and Hepatology.
Hughes, A, Dahmus, J, Rivas, G, Hummer, B, Chen See, JR, Wright, JR, Lamendella, R, Schmitz, KH, Sciamanna, C, Ruffin, M, Patterson, AD, Loomba, R & Stine, JG 2021, 'Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study', Clinical Gastroenterology and Hepatology.
Faust, A & Stine, JG 2021, 'Leveraging the Coronavirus Disease 2019 Pandemic: Is It Time to Consider Incorporating Mobile Applications Into Standard Clinical Management of the Liver Transplantation Patient?', Liver Transplantation, vol. 27, no. 4, pp. 479-481.
Niccum, BA, Stine, JG, Wynter, JA, Kelly, V, Caldwell, SH & Shah, NL 2021, 'Success of direct-acting, antiviral-based therapy for chronic hepatitis C is not affected by type 2 diabetes', Clinical Diabetes, vol. 38, no. 1, pp. 40-46.
Faust, A & Stine, JG 2021, 'Time to Step It Up: Mobile Health Intervention for Lifestyle Modification in Patients with Nonalcoholic Fatty Liver Disease', Digestive Diseases and Sciences.


Stine, JG, Soriano, C, Schreibman, I, Rivas, G, Hummer, B, Yoo, E, Schmitz, K & Sciamanna, C 2020, 'Breaking Down Barriers to Physical Activity in Patients with Nonalcoholic Fatty Liver Disease', Digestive Diseases and Sciences.
Clarke, K, Kang, M, Gorrepati, VS, Stine, JG, Tinsley, A, Williams, E, Moyer, M & Coates, M 2020, 'Dysplasia detection is similar between chromoendoscopy and high-definition white-light colonoscopy in inflammatory bowel disease patients: a US-matched case-control study', International Journal of Colorectal Disease, vol. 35, no. 12, pp. 2301-2307.
Mellinger, JL & Stine, JG 2020, 'Early Liver Transplantation for Severe Alcoholic Hepatitis', Digestive Diseases and Sciences, vol. 65, no. 6, pp. 1608-1614.
Stine, JG, Xu, D, Schmitz, K, Sciamanna, C & Kimball, SR 2020, 'Exercise Attenuates Ribosomal Protein Six Phosphorylation in Fatty Liver Disease', Digestive Diseases and Sciences, vol. 65, no. 11, pp. 3238-3243.
Bezinover, D, Nahouraii, L, Sviatchenko, A, Wang, M, Kimatian, S, Saner, FH & Stine, JG 2020, 'Hyponatremia is associated with increased mortality in children on the waiting list for liver transplantation', Transplantation Direct. <>
Spinosa, M & Stine, JG 2020, 'Nonalcoholic fatty liver disease-evidence for a thrombophilic state?', Current Pharmaceutical Design, vol. 26, no. 10, pp. 1036-1044.
Stine, JG, Schreibman, I, Navabi, S, Kang, M, Dahmus, J, Soriano, C, Rivas, G, Hummer, B, Beyer, M, Tressler, H, Kimball, SR, Patterson, AD, Schmitz, K & Sciamanna, C 2020, 'Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH', Contemporary Clinical Trials Communications, vol. 18, 100560.
Verbeek, TA, Stine, JG, Saner, FH & Bezinover, D 2020, 'Osmotic demyelination syndrome: are patients with end-stage liver disease a special risk group?', Minerva anestesiologica, vol. 86, no. 7, pp. 756-767.


Stine, JG, Intagliata, NM, Shah, NL, Lisman, T, Violi, F, Caldwell, SH & Argo, CK 2020, 'Clinical Cirrhosis Dilemmas: Survey of Practice from the 7th International Coagulation in Liver Disease Conference', Digestive Diseases and Sciences, vol. 65, no. 5, pp. 1334-1339.
Stine, J 2019, 'Concise Commentary: The Clot Thickens—Why Pylephlebitis Is One of the Most Feared Complications of Intra-abdominal Sepsis', Digestive Diseases and Sciences, vol. 64, no. 6, pp. 1722-1723.
Gaballa, D, Bezinover, D, Kadry, Z, Eyster, E, Wang, M, Northup, PG & Stine, JG 2019, 'Development of a Model to Predict Portal Vein Thrombosis in Liver Transplant Candidates: The Portal Vein Thrombosis Risk Index', Liver Transplantation, vol. 25, no. 12, pp. 1747-1755.
Bezinover, D, Navabi, S, Wang, M, Li, Z, William, M & Stine, JG 2019, 'Hyponatremia Is Protective Against the Development of Portal Vein Thrombosis in Patients Undergoing Liver Transplant', Transplantation proceedings, vol. 51, no. 6, pp. 1880-1886.
Ma, S, Wang, J, Bezinover, D, Kadry, Z, Northrup, P & Stine, J 2019, 'Inherited thrombophilia and portal vein thrombosis in cirrhosis: A systematic review and meta‐analysis', Research and Practice in Thrombosis and Haemostasis, vol. 3, no. 4, pp. 658-667. <>
Stine, JG 2020, 'I’m a Junior Faculty Member at an Academic Medical Center…Now What?', Digestive Diseases and Sciences, vol. 65, no. 1, pp. 15-17.
Stine, JG, Stukenborg, GJ, Wang, J, Adkins, A, Niccum, B, Zimmet, A & Argo, CK 2020, 'Liver transplant candidates have impaired quality of life across health domains as assessed by computerized testing', Annals of Hepatology, vol. 19, no. 1, pp. 62-68.
Shenoy, A, Stine, JG & Intagliata, NM 2019, 'Venous thromboembolism in patients with liver diseases: comment', Journal of Thrombosis and Haemostasis, vol. 17, no. 1, pp. 238-239.


Intagliata, NM, Argo, CK, Stine, JG, Lisman, T, Caldwell, SH & Violi, F 2018, 'Concepts and Controversies in Haemostasis and Thrombosis Associated with Liver Disease: Proceedings of the 7th International Coagulation in Liver Disease Conference', Thrombosis and Haemostasis, vol. 118, no. 8, pp. 1491-1506.
Stine, JG, Bezinover, D & Kadry, Z 2018, 'Coronary artery disease in decompensated patients undergoing liver transplantation evaluation', Liver Transplantation, vol. 24, no. 7, pp. 976-977.
Stine, JG, Wang, J, Shah, PM, Argo, CK, Intagliata, N, Uflacker, A, Caldwell, SH & Northup, PG 2018, 'Decreased portal vein velocity is predictive of the development of portal vein thrombosis: A matched case-control study', Liver International, vol. 38, no. 1, pp. 94-101.
Stine, JG, Northup, PG, Stukenborg, GJ, Cornella, SL, Maluf, DG, Pelletier, SJ & Argo, CK 2018, 'Geographic variation in liver transplantation persists despite implementation of Share35', Hepatology Research, vol. 48, no. 4, pp. 225-232.
Kaps, L, Stine, J, Mellinger, JL & Vilarinho, S 2018, 'Great expectations: Principal investigator and trainee perspectives on hiring, supervision, and mentoring', Hepatology Communications, vol. 2, no. 9, pp. 999-1004. <>
Verbeek, TA, Stine, JG, Saner, FH & Bezinover, D 2018, 'Hypercoagulability in end-stage liver disease: Review of epidemiology, etiology, and management', Transplantation Direct, vol. 4, no. 11, e401.
Stine, JG, Niccum, BA, Zimmet, AN, Intagliata, N, Caldwell, SH, Argo, CK & Northup, PG 2018, 'Increased risk of venous thromboembolism in hospitalized patients with cirrhosis due to non-alcoholic steatohepatitis original-contribution', Clinical and Translational Gastroenterology, vol. 9, no. 3, 140.
Stine, J & Northup, PG 2019, 'Management of Non-tumoral Portal Vein Thrombosis in Patients with Cirrhosis', Digestive Diseases and Sciences, vol. 64, no. 3, pp. 619-626.
Bezinover, D, Deacutis, MF, Dalal, P, Moore, RP, Stine, J, Wang, M, Reeder, E, Hollenbeak, CS, Saner, FH, Riley III, T & Janicki, P 2019, 'Perioperative thrombotic complications associated with pediatric liver transplantation: a UNOS database evaluation', HPB, vol. 21, no. 3, pp. 370-378.
Argo, CK, Stine, J, Henry, ZH, Lackner, C, Patrie, JT, Weltman, AL & Caldwell, SH 2018, 'Physical deconditioning is the common denominator in both obese and overweight subjects with nonalcoholic steatohepatitis', Alimentary Pharmacology and Therapeutics, vol. 48, no. 3, pp. 290-299.
Stine, JG, Prakash, S & Northup, PG 2018, 'Portal vein thrombosis after hepatitis C eradication with direct acting antiviral therapy', Liver International, vol. 38, no. 1, pp. 185-186.
Stine, JG, Wentworth, BJ, Zimmet, A, Rinella, ME, Loomba, R, Caldwell, SH & Argo, CK 2018, 'Systematic review with meta-analysis: risk of hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis compared to other liver diseases', Alimentary Pharmacology and Therapeutics, vol. 48, no. 7, pp. 696-703.
Stine, JG, Wang, J, Cornella, SL, Behm, BW, Henry, Z, Shah, NL, Caldwell, SH & Northup, PG 2018, 'Treatment of type-1 hepatorenal syndrome with pentoxifylline: A randomized placebo controlled clinical trial', Annals of Hepatology, vol. 17, no. 2, pp. 300-306.
Buckholz, A, Orton, C, Stine, J, Moskaluk, CA & Powell, S 2018, 'Universal Immunohistochemistry Screening for Lynch Syndrome: Real World Lessons from an Academic Institutional Experience', Current Trends in Internal Medicine. <>


Stine, JG, Argo, CK, Pelletier, SJ, Maluf, DG, Caldwell, SH & Northup, PG 2017, 'Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis', World Journal of Hepatology, vol. 9, no. 3, pp. 139-146.
Stine, JG & Northup, PG 2017, 'Coagulopathy Before and After Liver Transplantation: From the Hepatic to the Systemic Circulatory Systems', Clinics in Liver Disease, vol. 21, no. 2, pp. 253-274.
Stine, JG & Chalasani, NP 2017, 'Drug Hepatotoxicity: Environmental Factors', Clinics in Liver Disease, vol. 21, no. 1, pp. 103-113.
Stine, JG & Rinella, ME 2017, 'Editorial: Age and Non-Invasive Markers of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease: Time to Adjust the Clock?', American Journal of Gastroenterology, vol. 112, no. 5, pp. 752-754.
Stine, JG, Wynter, JA, Niccum, B, Kelly, V, Caldwell, SH & Shah, NL 2017, 'Effect of treatment with direct acting antiviral on glycemic control in patients with diabetes mellitus and chronic hepatitis C', Annals of Hepatology, vol. 16, no. 2, pp. 215-220.
Stine, JG, Intagliata, N, Northup, PG & Caldwell, SH 2017, 'Nonalcoholic Fatty Liver Disease, Portal Vein Thrombosis and Coagulation: More Questions Than Answers?', Transplantation, vol. 101, no. 8, pp. e281-e282.
Stine, JG, Wynter, JA, Niccum, B, Kelly, V, Caldwell, SH & Shah, NL 2017, 'Reply to “HbA1c levels as a parameter of glycemic control in patients with liver cirrhosis”', Annals of Hepatology, vol. 16, no. 3, pp. 471-472.
Myc, LA, Stine, JG, Chakrapani, R, Kadl, A & Argo, CK 2017, 'Vasopressin use in critically ill cirrhosis patients with catecholamine-resistant septic shock: The CVICU cohort', World Journal of Hepatology, vol. 9, no. 2, pp. 106-113.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)