Researcher Profile
Researcher Profile
Jonathan Stine, MD, MSc
Associate Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Associate Professor, Department of Public Health Sciences
Division of Gastroenterology and Hepatology
Associate Professor, Department of Public Health Sciences
Scientific Program:Cancer Control
Research Interests
Dr. Jonathan Stine is an internationally recognized liver expert with a research and clinical focus on nonalcoholic fatty liver disease and exercise. He has authored more than 70 peer-reviewed papers, including multinational consensus guidelines, and several book chapters.
Stine is the recipient of multiple research grants and awards from the American Association for the Study of Liver Diseases, American Cancer Society and National Institutes of Health. He has been a study investigator on more than 20 nonalcoholic fatty liver disease clinical trials and is on the editorial board for several leading hepatology journals.
In addition to his scholarly work, Stine is research director for Penn State Health Liver Center. He is also a core faculty member of The ONE Group (Oncology - Nutrition - Exercise).
- Fibrosis
- Liver Transplantation
- Thrombosis
- Portal Vein
- Non-alcoholic Fatty Liver Disease
- Liver
- Therapeutics
- Chemical and Drug Induced Liver Injury
- Exercise
- Systematic Reviews
- Fatty Liver
- Mortality
Recent Publications
2022
Drug-Induced Liver Injury Network (DILIN) Study Investigators 2022, 'Clinical characteristics of antiepileptic-induced liver injury in patients from the DILIN prospective study', Journal of Hepatology, vol. 76, no. 4, pp. 832-840. https://doi.org/10.1016/j.jhep.2021.12.013
Stine, JG, Schreibman, IR, Faust, AJ, Dahmus, J, Stern, B, Soriano, C, Rivas, G, Hummer, B, Kimball, SR, Geyer, NR, Chinchilli, VM, Loomba, R, Schmitz, K, Sciamanna, C, Strine, C, Wentzel, R, Marlin, S, Sica, C, Vesek, J, Eyster, E, Sinoway, L, Bentz, K, Handley, N, Hershey Fell, B, Mottilla, S, Christ, C, George, S, Novchich, T, Beyer, M, Clarke, K, Myers, T, Glading-Steinruck, M, Krok, K, Ma, T, Riley, T, Thompson, E, Tressler, H, Broach, J, Doan, T, Patrick, S, Reed, S, Hamilton, C, Slavoski, K & Tregea, D 2022, 'NASHFit: A randomized controlled trial of an exercise training program to reduce clotting risk in patients with NASH', Hepatology, vol. 76, no. 1, pp. 172-185. https://doi.org/10.1002/hep.32274
DiJoseph, K, Thorp, A, Harrington, A, Schmitz, K, Chinchilli, VM & Stine, JG 2022, 'Physical Activity and Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis', Digestive Diseases and Sciences. https://doi.org/10.1007/s10620-022-07601-w
Clarke, K, DiJoseph, K, White, R, Yaghnam, I, Lee, R & Stine, JG 2022, 'Post-polypectomy follow-up recommendations by practicing academic gastroenterologists—does number of years in practice matter?', International Journal of Colorectal Disease, vol. 37, no. 4, pp. 979-982. https://doi.org/10.1007/s00384-022-04120-y
Stine, JG, Schreibman, IR, Faust, AJ, Dahmus, J, Stern, B, Soriano, C, Rivas, G, Hummer, B, Kimball, SR, Geyer, NR, Chinchilli, VM, Schmitz, K & Sciamanna, C 2022, 'Reply', Hepatology, vol. 76, no. 1, pp. E18-E19. https://doi.org/10.1002/hep.32390
2021
Bezinover, D, Geyer, NR, Dahmus, J, Chinchilli, VM & Stine, JG 2022, 'A decline in functional status while awaiting liver transplantation is predictive of increased post-transplantation mortality', HPB, vol. 24, no. 6, pp. 825-832. https://doi.org/10.1016/j.hpb.2021.10.008
Intagliata, NM, Davitkov, P, Allen, AM, Falck-Ytter, YT & Stine, JG 2021, 'AGA Technical Review on Coagulation in Cirrhosis', Gastroenterology, vol. 161, no. 5, pp. 1630-1656. https://doi.org/10.1053/j.gastro.2021.09.004
Stine, JG, Munaganuru, N, Barnard, A, Wang, JL, Kaulback, K, Argo, CK, Singh, S, Fowler, KJ, Sirlin, CB & Loomba, R 2021, 'Change in MRI-PDFF and Histologic Response in Patients With Nonalcoholic Steatohepatitis: A Systematic Review and Meta-Analysis', Clinical Gastroenterology and Hepatology, vol. 19, no. 11, pp. 2274-2283.e5. https://doi.org/10.1016/j.cgh.2020.08.061
Kadry, Z, Schaefer, E, Krok, K, Faust, A, Stine, JG, Schreibman, IR, Bezinover, D & Riley, TR 2021, 'Excellent outcomes with liver transplantation in hepatopulmonary syndrome across pre-transplant PaO2 spectrum', JHEP Reports, vol. 3, no. 5, 100351. https://doi.org/10.1016/j.jhepr.2021.100351
Hughes, A, Dahmus, J, Rivas, G, Hummer, B, Chen See, JR, Wright, JR, Lamendella, R, Schmitz, KH, Sciamanna, C, Ruffin, M, Patterson, AD, Loomba, R & Stine, JG 2021, 'Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study', Clinical Gastroenterology and Hepatology, vol. 19, no. 8, pp. 1723-1725. https://doi.org/10.1016/j.cgh.2020.08.063
Faust, A & Stine, JG 2021, 'Leveraging the Coronavirus Disease 2019 Pandemic: Is It Time to Consider Incorporating Mobile Applications Into Standard Clinical Management of the Liver Transplantation Patient?', Liver Transplantation, vol. 27, no. 4, pp. 479-481. https://doi.org/10.1002/lt.25991
Sharma, S, Stine, JG, Verbeek, T & Bezinover, D 2022, 'Management of Patients With Non-alcoholic Steatohepatitis Undergoing Liver Transplantation: Considerations for the Anesthesiologist', Journal of cardiothoracic and vascular anesthesia, vol. 36, no. 8, pp. 2616-2627. https://doi.org/10.1053/j.jvca.2021.07.020
Rivas, G, Hummer-Bair, B, Bezinover, D, Kadry, Z & Stine, J 2021, 'Plasminogen activator inhibitor is significantly elevated in liver transplant recipients with decompensated NASH cirrhosis', BMJ Open Gastroenterology, vol. 8, no. 1, e000683. https://doi.org/10.1136/bmjgast-2021-000683
Kadry, Z, Stine, JG, Dohi, T, Jain, A, Robyak, KL, Kwon, O, Hamilton, CJ, Janicki, P, Riley, TR, Butt, F, Krok, K, Schreibman, IR, Bezinover, D, Ghahramani, N, Campos, S & Hollenbeak, CS 2021, 'Renal Protective Effect of Everolimus in Liver Transplantation: A Prospective Randomized Open-Label Trial', Transplantation Direct. https://doi.org/10.1097/TXD.0000000000001159
Niccum, BA, Stine, JG, Wynter, JA, Kelly, V, Caldwell, SH & Shah, NL 2021, 'Success of direct-acting, antiviral-based therapy for chronic hepatitis C is not affected by type 2 diabetes', Clinical Diabetes, vol. 38, no. 1, pp. 40-46. https://doi.org/10.2337/cd18-0112
Faust, A & Stine, JG 2022, 'Time to Step It Up: Mobile Health Intervention for Lifestyle Modification in Patients with Nonalcoholic Fatty Liver Disease', Digestive Diseases and Sciences, vol. 67, no. 2, pp. 403-405. https://doi.org/10.1007/s10620-021-07018-x
Motz, V, Faust, A, Dahmus, J, Stern, B, Soriano, C & Stine, JG 2021, 'Utilization of a directly supervised telehealth-based exercise training program in patients with nonalcoholic steatohepatitis: Feasibility study', JMIR Formative Research, vol. 5, no. 8, e30239. https://doi.org/10.2196/30239
Ladwig, MA, Sciamanna, CN, Auer, BJ, Oser, TK, Stine, JG & Agans, JP 2021, 'When American adults do move, how do they do so? Trends in physical activity intensity, type, and modality: 1988-2017', Journal of Physical Activity and Health, vol. 18, no. 10, pp. 1181-1198. https://doi.org/10.1123/jpah.2020-0424
2020
Stine, JG, Soriano, C, Schreibman, I, Rivas, G, Hummer, B, Yoo, E, Schmitz, K & Sciamanna, C 2021, 'Breaking Down Barriers to Physical Activity in Patients with Nonalcoholic Fatty Liver Disease', Digestive Diseases and Sciences, vol. 66, no. 10, pp. 3604-3611. https://doi.org/10.1007/s10620-020-06673-w
Clarke, K, Kang, M, Gorrepati, VS, Stine, JG, Tinsley, A, Williams, E, Moyer, M & Coates, M 2020, 'Dysplasia detection is similar between chromoendoscopy and high-definition white-light colonoscopy in inflammatory bowel disease patients: a US-matched case-control study', International Journal of Colorectal Disease, vol. 35, no. 12, pp. 2301-2307. https://doi.org/10.1007/s00384-020-03719-3
Mellinger, JL & Stine, JG 2020, 'Early Liver Transplantation for Severe Alcoholic Hepatitis', Digestive Diseases and Sciences, vol. 65, no. 6, pp. 1608-1614. https://doi.org/10.1007/s10620-020-06159-9
Stine, JG, Xu, D, Schmitz, K, Sciamanna, C & Kimball, SR 2020, 'Exercise Attenuates Ribosomal Protein Six Phosphorylation in Fatty Liver Disease', Digestive Diseases and Sciences, vol. 65, no. 11, pp. 3238-3243. https://doi.org/10.1007/s10620-020-06226-1
Bezinover, D, Nahouraii, L, Sviatchenko, A, Wang, M, Kimatian, S, Saner, FH & Stine, JG 2020, 'Hyponatremia is associated with increased mortality in children on the waiting list for liver transplantation', Transplantation Direct. <https://journals.lww.com/transplantationdirect/Fulltext/2020/10000/Hyponatremia_Is_Associated_With_Increased.4.aspx>
Spinosa, M & Stine, JG 2020, 'Nonalcoholic fatty liver disease-evidence for a thrombophilic state?', Current Pharmaceutical Design, vol. 26, no. 10, pp. 1036-1044. https://doi.org/10.2174/1381612826666200131101553
Stine, JG, Schreibman, I, Navabi, S, Kang, M, Dahmus, J, Soriano, C, Rivas, G, Hummer, B, Beyer, M, Tressler, H, Kimball, SR, Patterson, AD, Schmitz, K & Sciamanna, C 2020, 'Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH', Contemporary Clinical Trials Communications, vol. 18, 100560. https://doi.org/10.1016/j.conctc.2020.100560
Verbeek, TA, Stine, JG, Saner, FH & Bezinover, D 2020, 'Osmotic demyelination syndrome: are patients with end-stage liver disease a special risk group?', Minerva anestesiologica, vol. 86, no. 7, pp. 756-767. https://doi.org/10.23736/S0375-9393.20.14120-8
2019
Stine, JG, Intagliata, NM, Shah, NL, Lisman, T, Violi, F, Caldwell, SH & Argo, CK 2020, 'Clinical Cirrhosis Dilemmas: Survey of Practice from the 7th International Coagulation in Liver Disease Conference', Digestive Diseases and Sciences, vol. 65, no. 5, pp. 1334-1339. https://doi.org/10.1007/s10620-019-05884-0
Stine, J 2019, 'Concise Commentary: The Clot Thickens—Why Pylephlebitis Is One of the Most Feared Complications of Intra-abdominal Sepsis', Digestive Diseases and Sciences, vol. 64, no. 6, pp. 1722-1723. https://doi.org/10.1007/s10620-018-5440-6
Gaballa, D, Bezinover, D, Kadry, Z, Eyster, E, Wang, M, Northup, PG & Stine, JG 2019, 'Development of a Model to Predict Portal Vein Thrombosis in Liver Transplant Candidates: The Portal Vein Thrombosis Risk Index', Liver Transplantation, vol. 25, no. 12, pp. 1747-1755. https://doi.org/10.1002/lt.25630
Bezinover, D, Navabi, S, Wang, M, Li, Z, William, M & Stine, JG 2019, 'Hyponatremia Is Protective Against the Development of Portal Vein Thrombosis in Patients Undergoing Liver Transplant', Transplantation proceedings, vol. 51, no. 6, pp. 1880-1886. https://doi.org/10.1016/j.transproceed.2019.05.014
Ma, SD, Wang, J, Bezinover, D, Kadry, Z, Northup, PG & Stine, JG 2019, 'Inherited thrombophilia and portal vein thrombosis in cirrhosis: A systematic review and meta-analysis', Research and Practice in Thrombosis and Haemostasis, vol. 3, no. 4, pp. 658-667. https://doi.org/10.1002/rth2.12253
Ma, S, Wang, J, Bezinover, D, Kadry, Z, Northrup, P & Stine, J 2019, 'Inherited thrombophilia and portal vein thrombosis in cirrhosis: A systematic review and meta‐analysis', Research and Practice in Thrombosis and Haemostasis, vol. 3, no. 4, pp. 658-667. <https://onlinelibrary.wiley.com/doi/full/10.1002/rth2.12253>
Stine, JG 2020, 'I’m a Junior Faculty Member at an Academic Medical Center…Now What?', Digestive Diseases and Sciences, vol. 65, no. 1, pp. 15-17. https://doi.org/10.1007/s10620-019-05946-3
Stine, JG, Stukenborg, GJ, Wang, J, Adkins, A, Niccum, B, Zimmet, A & Argo, CK 2020, 'Liver transplant candidates have impaired quality of life across health domains as assessed by computerized testing', Annals of Hepatology, vol. 19, no. 1, pp. 62-68. https://doi.org/10.1016/j.aohep.2019.06.018
Shenoy, A, Stine, JG & Intagliata, NM 2019, 'Venous thromboembolism in patients with liver diseases: comment', Journal of Thrombosis and Haemostasis, vol. 17, no. 1, pp. 238-239. https://doi.org/10.1111/jth.14320
2018
Intagliata, NM, Argo, CK, Stine, JG, Lisman, T, Caldwell, SH & Violi, F 2018, 'Concepts and Controversies in Haemostasis and Thrombosis Associated with Liver Disease: Proceedings of the 7th International Coagulation in Liver Disease Conference', Thrombosis and Haemostasis, vol. 118, no. 8, pp. 1491-1506. https://doi.org/10.1055/s-0038-1666861
Stine, JG, Bezinover, D & Kadry, Z 2018, 'Coronary artery disease in decompensated patients undergoing liver transplantation evaluation', Liver Transplantation, vol. 24, no. 7, pp. 976-977. https://doi.org/10.1002/lt.25064
Stine, JG, Wang, J, Shah, PM, Argo, CK, Intagliata, N, Uflacker, A, Caldwell, SH & Northup, PG 2018, 'Decreased portal vein velocity is predictive of the development of portal vein thrombosis: A matched case-control study', Liver International, vol. 38, no. 1, pp. 94-101. https://doi.org/10.1111/liv.13500
Stine, JG, Northup, PG, Stukenborg, GJ, Cornella, SL, Maluf, DG, Pelletier, SJ & Argo, CK 2018, 'Geographic variation in liver transplantation persists despite implementation of Share35', Hepatology Research, vol. 48, no. 4, pp. 225-232. https://doi.org/10.1111/hepr.12922
Kaps, L, Stine, J, Mellinger, JL & Vilarinho, S 2018, 'Great expectations: Principal investigator and trainee perspectives on hiring, supervision, and mentoring', Hepatology Communications, vol. 2, no. 9, pp. 999-1004. <https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep4.1205>
Verbeek, TA, Stine, JG, Saner, FH & Bezinover, D 2018, 'Hypercoagulability in end-stage liver disease: Review of epidemiology, etiology, and management', Transplantation Direct, vol. 4, no. 11, e401. https://doi.org/10.1097/TXD.0000000000000843
Stine, JG, Niccum, BA, Zimmet, AN, Intagliata, N, Caldwell, SH, Argo, CK & Northup, PG 2018, 'Increased risk of venous thromboembolism in hospitalized patients with cirrhosis due to non-alcoholic steatohepatitis original-contribution', Clinical and Translational Gastroenterology, vol. 9, no. 3, 140. https://doi.org/10.1038/s41424-018-0002-y
Stine, J & Northup, PG 2019, 'Management of Non-tumoral Portal Vein Thrombosis in Patients with Cirrhosis', Digestive Diseases and Sciences, vol. 64, no. 3, pp. 619-626. https://doi.org/10.1007/s10620-018-5427-3
Bezinover, D, Deacutis, MF, Dalal, P, Moore, RP, Stine, J, Wang, M, Reeder, E, Hollenbeak, CS, Saner, FH, Riley III, T & Janicki, P 2019, 'Perioperative thrombotic complications associated with pediatric liver transplantation: a UNOS database evaluation', HPB, vol. 21, no. 3, pp. 370-378. https://doi.org/10.1016/j.hpb.2018.08.014
Argo, CK, Stine, J, Henry, ZH, Lackner, C, Patrie, JT, Weltman, AL & Caldwell, SH 2018, 'Physical deconditioning is the common denominator in both obese and overweight subjects with nonalcoholic steatohepatitis', Alimentary Pharmacology and Therapeutics, vol. 48, no. 3, pp. 290-299. https://doi.org/10.1111/apt.14803
Stine, JG, Prakash, S & Northup, PG 2018, 'Portal vein thrombosis after hepatitis C eradication with direct acting antiviral therapy', Liver International, vol. 38, no. 1, pp. 185-186. https://doi.org/10.1111/liv.13537
Stine, JG, Wentworth, BJ, Zimmet, A, Rinella, ME, Loomba, R, Caldwell, SH & Argo, CK 2018, 'Systematic review with meta-analysis: risk of hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis compared to other liver diseases', Alimentary Pharmacology and Therapeutics, vol. 48, no. 7, pp. 696-703. https://doi.org/10.1111/apt.14937
Stine, JG, Wang, J, Cornella, SL, Behm, BW, Henry, Z, Shah, NL, Caldwell, SH & Northup, PG 2018, 'Treatment of type-1 hepatorenal syndrome with pentoxifylline: A randomized placebo controlled clinical trial', Annals of Hepatology, vol. 17, no. 2, pp. 300-306. https://doi.org/10.5604/01.3001.0010.8660
Buckholz, A, Orton, C, Stine, J, Moskaluk, CA & Powell, S 2018, 'Universal Immunohistochemistry Screening for Lynch Syndrome: Real World Lessons from an Academic Institutional Experience', Current Trends in Internal Medicine.