Researcher Profile

Researcher Profile

Vishal Singh

Vishal Singh

Assistant Professor, Nutritional Sciences
Scientific Program:Mechanisms of Carcinogenesis
vxs28@psu.edu

Research Interests

  • Inflammation
  • Microbiota
  • Lipocalin-2
  • Diet
  • Atherosclerosis
  • Colitis
  • Cholesterol
  • Gastrointestinal Microbiome
  • turmeric extract
  • Interleukin-1
  • Monocytes
  • Macrophages

Recent Publications

2019

Singh, A, Singh, V, Tiwari, RL, Chandra, T, Kumar, A, Dikshit, M & Barthwal, MK 2019, 'Correction to: The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes (Cellular & Molecular Immunology, (2016), 13, 6, (745-763), 10.1038/cmi.2015.62)', Cellular and Molecular Immunology, vol. 16, no. 12. https://doi.org/10.1038/s41423-019-0286-1
Singh, V, Yeoh, BS, Walker, RE, Xiao, X, Saha, P, Golonka, RM, Cai, J, Bretin, ACA, Cheng, X, Liu, Q, Flythe, MD, Chassaing, B, Shearer, GC, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2019, 'Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation', Gut, vol. 68, no. 10, pp. 1801-1812. https://doi.org/10.1136/gutjnl-2018-316250
Saha, P, Yeoh, BS, Xiao, X, Golonka, RM, Singh, V, Wang, Y & Vijay-Kumar, M 2019, 'PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium', Mucosal Immunology, vol. 12, no. 3, pp. 761-771. https://doi.org/10.1038/s41385-019-0139-3

2018

Singh, V, Yeoh, BS, Chassaing, B, Xiao, X, Saha, P, Aguilera Olvera, R, Lapek, JD, Zhang, L, Wang, WB, Hao, S, Flythe, MD, Gonzalez, DJ, Cani, PD, Conejo-Garcia, JR, Xiong, N, Kennett, MJ, Joe, B, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2018, 'Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer', Cell, vol. 175, no. 3, pp. 679-694.e22. https://doi.org/10.1016/j.cell.2018.09.004
Xiao, X, Saha, P, Yeoh, BS, Hipp, JA, Singh, V & Vijay-Kumar, M 2018, 'Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects', Journal of Nutritional Biochemistry, vol. 62, pp. 28-34. https://doi.org/10.1016/j.jnutbio.2018.08.003
Chakraborty, S, Galla, S, Cheng, X, Yeo, JY, Mell, B, Singh, V, Yeoh, BS, Saha, P, Mathew, AV, Vijay-Kumar, M & Joe, B 2018, 'Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension', Cell Reports, vol. 25, no. 3, pp. 677-689.e4. https://doi.org/10.1016/j.celrep.2018.09.058
Kanshana, JS, Rebello, SC, Pathak, P, Kanuri, BN, Aggarwal, H, Srivastava, V, Khanna, V, Singh, V, Jagavelu, K, Barthwal, MK & Dikshit, M 2018, 'Standardized fraction of Xylocarpus moluccensis fruits improve vascular relaxation and plaque stability in dyslipidemic models of atherosclerosis', Journal of Ethnopharmacology, vol. 213, pp. 81-91. https://doi.org/10.1016/j.jep.2017.11.004

2017

Saha, P, Yeoh, BS, Olvera, RA, Xiao, X, Singh, V, Awasthi, D, Subramanian, BC, Chen, Q, Dikshit, M, Wang, Y, Parent, CA & Vijay-Kumar, M 2017, 'Bacterial siderophores hijack neutrophil functions', Journal of Immunology, vol. 198, no. 11, pp. 4293-4303. https://doi.org/10.4049/jimmunol.1700261
Singh, V, Yeoh, BS, Nilsen-Hamilton, M, Berger, T, Mak, TW & Vijay-Kumar, M 2017, 'Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background', Data in Brief, vol. 11, pp. 588-592. https://doi.org/10.1016/j.dib.2017.03.002
Saha, P, Chassaing, B, Yeoh, BS, Viennois, E, Xiao, X, Kennett, MJ, Singh, V & Vijay-Kumar, M 2017, 'Ectopic Expression of Innate Immune Protein, Lipocalin-2, in Lactococcus lactis Protects Against Gut and Environmental Stressors', Inflammatory bowel diseases, vol. 23, no. 7, pp. 1120-1132. https://doi.org/10.1097/MIB.0000000000001134
Zou, J, Chassaing, B, Singh, V, Pellizzon, M, Ricci, M, Fythe, MD, Kumar, MV & Gewirtz, AT 2018, 'Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health', Cell Host and Microbe, vol. 23, no. 1, pp. 41-53.e4. https://doi.org/10.1016/j.chom.2017.11.003
Xiao, X, Yeoh, BS, Saha, P, Tian, Y, Singh, V, Patterson, AD & Vijay-Kumar, M 2017, 'Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice', Journal of Nutritional Biochemistry, vol. 41, pp. 25-33. https://doi.org/10.1016/j.jnutbio.2016.11.014
Kanshana, JS, Khanna, V, Singh, V, Jain, M, Misra, A, Kumar, S, Farooqui, M, Barthwal, MK & Dikshit, M 2017, 'Progression and Characterization of the Accelerated Atherosclerosis in Iliac Artery of New Zealand White Rabbits: Effect of Simvastatin', Journal of Cardiovascular Pharmacology, vol. 69, no. 5, pp. 314-325. https://doi.org/10.1097/FJC.0000000000000477

2016

Rana, M, Maurya, P, Reddy, SS, Singh, V, Ahmad, H, Dwivedi, AK, Dikshit, M & Barthwal, MK 2016, 'A standardized chemically modified Curcuma longa extract modulates IRAK-MAPK signaling in inflammation and potentiates cytotoxicity', Frontiers in Pharmacology, vol. 7, no. JUL, 223. https://doi.org/10.3389/fphar.2016.00223
Saha, P, Singh, V, Xiao, X, Yeoh, BS & Kumar, MV 2016, 'Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation', Data in Brief, vol. 8, pp. 812-816. https://doi.org/10.1016/j.dib.2016.06.047
Yeoh, BS, Saha, P, Singh, V, Xiao, X, Ying, Y, Vanamala, JK, Kennett, MJ, Harvatine, KJ, Joe, B & Vijay-Kumar, M 2016, 'Deficiency of stearoyl-CoA desaturase-1 aggravates colitogenic potential of adoptively transferred effector T cells', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 311, no. 4, pp. G713-G723. https://doi.org/10.1152/ajpgi.00174.2016
Yeoh, BS, Aguilera Olvera, R, Singh, V, Xiao, X, Kennett, MJ, Joe, B, Lambert, JD & Vijay-Kumar, M 2016, 'Epigallocatechin-3-gallate inhibition of myeloperoxidase and its counter-regulation by dietary iron and lipocalin 2 in murine model of gut inflammation', American Journal of Pathology, vol. 186, no. 4, pp. 912-926. https://doi.org/10.1016/j.ajpath.2015.12.004
Singh, V, Yeoh, BS & Vijay-Kumar, M 2016, 'Feed your gut with caution!', Translational Cancer Research, vol. 5, pp. S507-S513. https://doi.org/10.21037/tcr.2016.09.13
Jain, M, Singh, A, Singh, V, Maurya, P & Barthwal, MK 2016, 'Gingerol Inhibits Serum-Induced Vascular Smooth Muscle Cell Proliferation and Injury-Induced Neointimal Hyperplasia by Suppressing p38 MAPK Activation', Journal of Cardiovascular Pharmacology and Therapeutics, vol. 21, no. 2, pp. 187-200. https://doi.org/10.1177/1074248415598003
Singh, V, Yeoh, BS & Kumar, MV 2016, 'Gut microbiome as a novel cardiovascular therapeutic target', Current Opinion in Pharmacology, vol. 27, pp. 8-12. https://doi.org/10.1016/j.coph.2016.01.002
Rana, M, Kumar, A, Tiwari, RL, Singh, V, Chandra, T, Dikshit, M & Barthwal, MK 2016, 'IRAK regulates macrophage foam cell formation by modulating genes involved in cholesterol uptake and efflux', BioEssays, vol. 38, no. 7, pp. 591-604. https://doi.org/10.1002/bies.201600085
Singh, V, Kumar, M, San Yeoh, B, Xiao, X, Saha, P, Kennett, MJ & Vijay-Kumar, M 2016, 'Inhibition of interleukin-10 signaling induces microbiota-dependent chronic colitis in Apolipoprotein E deficient mice', Inflammatory bowel diseases, vol. 22, no. 4, pp. 841-852. https://doi.org/10.1097/MIB.0000000000000699
Xiao, X, Yeoh, BS, Saha, P, Olvera, RA, Singh, V & Kumar, MV 2016, 'Lipocalin 2 alleviates iron toxicity by facilitating hypoferremia of inflammation and limiting catalytic iron generation', BioMetals, vol. 29, no. 3, pp. 451-465. https://doi.org/10.1007/s10534-016-9925-5
Singh, V, Yeoh, BS, Chassaing, B, Zhang, B, Saha, P, Xiao, X, Awasthi, D, Shashidharamurthy, R, Dikshit, M, Gewirtz, A & Vijay-Kumar, M 2016, 'Microbiota-Inducible Innate Immune Siderophore Binding Protein Lipocalin 2 Is Critical for Intestinal Homeostasis', CMGH, vol. 2, no. 4, pp. 482-498.e6. https://doi.org/10.1016/j.jcmgh.2016.03.007
Singh, A, Singh, V, Tiwari, RL, Chandra, T, Kumar, A, Dikshit, M & Barthwal, MK 2016, 'The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes', Cellular and Molecular Immunology, vol. 13, no. 6, pp. 747-763. https://doi.org/10.1038/cmi.2015.62

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)