Vishal Singh - Penn State Cancer Institute
Researcher Profile
Vishal Singh
Associate Professor, Nutritional Sciences
One Health Microbiome Center
One Health Microbiome Center
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2025
Tian, S, Kim, MS, Zhao, J, Heber, K, Hao, F, Koslicki, D, Tian, S, Singh, V, Patterson, AD & Bisanz, JE 2025, 'A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistance', Cell Host and Microbe, vol. 33, no. 3, pp. 373-387.e9. https://doi.org/10.1016/j.chom.2025.02.007
Ginnan, N, Crandall, SG, Imchen, M, Dini-Andreote, F, Miyashiro, TI, Singh, V, Ganda, E & Bordenstein, SR 2025, 'Ecologically expanding the One Health framework to unify the microbiome sciences', mBio, vol. 16, no. 6. https://doi.org/10.1128/mbio.03147-24
Tian, S, Goand, UK, Paudel, D, Le, GV, Tiwari, AK, Prabhu, KS & Singh, V 2025, 'Processed dietary fiber partially hydrolyzed guar gum increases susceptibility to colitis and colon tumorigenesis in mice', npj Science of Food, vol. 9, no. 1, 114. https://doi.org/10.1038/s41538-025-00472-1
2024
Castro, R, Kalecký, K, Huang, NK, Petersen, K, Singh, V, Ross, AC, Neuberger, T & Bottiglieri, T 2024, 'A very-low carbohydrate content in a high-fat diet modifies the plasma metabolome and impacts systemic inflammation and experimental atherosclerosis', Journal of Nutritional Biochemistry, vol. 126, 109562. https://doi.org/10.1016/j.jnutbio.2023.109562
Rimal, B, Collins, SL, Tanes, CE, Rocha, ER, Granda, MA, Solanki, S, Hoque, NJ, Gentry, EC, Koo, I, Reilly, ER, Hao, F, Paudel, D, Singh, V, Yan, T, Kim, MS, Bittinger, K, Zackular, JP, Krausz, KW, Desai, D, Amin, S, Coleman, JP, Shah, YM, Bisanz, JE, Gonzalez, FJ, Vanden Heuvel, JP, Wu, GD, Zemel, BS, Dorrestein, PC, Weinert, EE & Patterson, AD 2024, 'Bile salt hydrolase catalyses formation of amine-conjugated bile acids', Nature, vol. 626, no. 8000, pp. 859-863. https://doi.org/10.1038/s41586-023-06990-w
Andrews, SG, Koehle, AM, Paudel, D, Neuberger, T, Ross, AC, Singh, V, Bottiglieri, T & Castro, R 2024, 'Diet-Induced Severe Hyperhomocysteinemia Promotes Atherosclerosis Progression and Dysregulates the Plasma Metabolome in Apolipoprotein-E-Deficient Mice', Nutrients, vol. 16, no. 3, 330. https://doi.org/10.3390/nu16030330
Paudel, D, Nair, DVT, Tian, S, Hao, F, Goand, UK, Joseph, G, Prodes, E, Chai, Z, Robert, CEM, Chassaing, B, Patterson, AD & Singh, V 2024, 'Dietary fiber guar gum-induced shift in gut microbiota metabolism and intestinal immune activity enhances susceptibility to colonic inflammation', Gut microbes, vol. 16, no. 1, 2341457. https://doi.org/10.1080/19490976.2024.2341457
Paudel, D, Hao, F, Goand, UK, Tian, S, Koehle, AM, Nguyen, LV, Tian, Y, Patterson, AD & Singh, V 2024, 'Elevated systemic total bile acids escalate susceptibility to alcohol-associated liver disease', iScience, vol. 27, no. 10, 110940. https://doi.org/10.1016/j.isci.2024.110940
Paudel, D, Nair, DVT, Joseph, G, Castro, R, Tiwari, AK & Singh, V 2024, 'Gastrointestinal microbiota-directed nutritional and therapeutic interventions for inflammatory bowel disease: opportunities and challenges', Gastroenterology Report, vol. 12, goae033. https://doi.org/10.1093/gastro/goae033
Thakur, CK, Karthikeyan, C, Ashby, CR, Neupane, R, Singh, V, Babu, RJ, Narayana Moorthy, NSH & Tiwari, AK 2024, 'Ligand-conjugated multiwalled carbon nanotubes for cancer targeted drug delivery', Frontiers in Pharmacology, vol. 15, 1417399. https://doi.org/10.3389/fphar.2024.1417399
2023
Godbole, MS & Singh, V 2023, 'Deciphering the impacts of gut and tissue microbiome on human cancers', Cancer Reports, vol. 6, no. 11, e1924. https://doi.org/10.1002/cnr2.1924
Tian, S, Paudel, D, Hao, F, Neupane, R, Castro, R, Patterson, AD, Tiwari, AK, Prabhu, KS & Singh, V 2023, 'Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production', Cancer Reports, vol. 6, no. 11, e1863. https://doi.org/10.1002/cnr2.1863
Nettleford, SK, Liao, C, Short, SP, Rossi, RM, Singh, V & Prabhu, KS 2023, 'Selenoprotein W Ameliorates Experimental Colitis and Promotes Intestinal Epithelial Repair', Antioxidants, vol. 12, no. 4, 850. https://doi.org/10.3390/antiox12040850
2022
Bachu, RD, Abou-Dahech, M, Balaji, S, Boddu, SHS, Amos, S, Singh, V, Babu, RJ & Tiwari, AK 2022, 'Oncology biosimilars: New developments and future directions', Cancer Reports, vol. 5, no. 11, e1720. https://doi.org/10.1002/cnr2.1720
Agarwal, H, Sukka, SR, Singh, V, Dikshit, M & Barthwal, MK 2022, 'Standardized fraction of Xylocarpus moluccensis inhibits inflammation by modulating MAPK-NFκB and ROS-HIF1α-PKM2 activation', Inflammation Research, vol. 71, no. 4, pp. 423-437. https://doi.org/10.1007/s00011-022-01549-3
Aggarwal, H, Pathak, P, Singh, V, Kumar, Y, Shankar, M, Das, B, Jagavelu, K & Dikshit, M 2022, 'Vancomycin-Induced Modulation of Gram-Positive Gut Bacteria and Metabolites Remediates Insulin Resistance in iNOS Knockout Mice', Frontiers in Cellular and Infection Microbiology, vol. 11, 795333. https://doi.org/10.3389/fcimb.2021.795333