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Vishal Singh

Vishal Singh

Assistant Professor, Nutritional Sciences
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Inflammation
  • Lipocalin-2
  • Microbiota
  • Gastrointestinal Microbiome
  • Diet
  • Colitis
  • Atherosclerosis
  • Cholesterol
  • Liver
  • turmeric extract
  • Interleukin-1
  • Macrophages

Recent Publications


Castro, R, Kalecký, K, Huang, NK, Petersen, K, Singh, V, Ross, AC, Neuberger, T & Bottiglieri, T 2024, 'A very-low carbohydrate content in a high-fat diet modifies the plasma metabolome and impacts systemic inflammation and experimental atherosclerosis', Journal of Nutritional Biochemistry, vol. 126, 109562.
Rimal, B, Collins, SL, Tanes, CE, Rocha, ER, Granda, MA, Solanki, S, Hoque, NJ, Gentry, EC, Koo, I, Reilly, ER, Hao, F, Paudel, D, Singh, V, Yan, T, Kim, MS, Bittinger, K, Zackular, JP, Krausz, KW, Desai, D, Amin, S, Coleman, JP, Shah, YM, Bisanz, JE, Gonzalez, FJ, Vanden Heuvel, JP, Wu, GD, Zemel, BS, Dorrestein, PC, Weinert, EE & Patterson, AD 2024, 'Bile salt hydrolase catalyses formation of amine-conjugated bile acids', Nature, vol. 626, no. 8000, pp. 859-863.
Andrews, SG, Koehle, AM, Paudel, D, Neuberger, T, Ross, AC, Singh, V, Bottiglieri, T & Castro, R 2024, 'Diet-Induced Severe Hyperhomocysteinemia Promotes Atherosclerosis Progression and Dysregulates the Plasma Metabolome in Apolipoprotein-E-Deficient Mice', Nutrients, vol. 16, no. 3, 330.


Godbole, MS & Singh, V 2023, 'Deciphering the impacts of gut and tissue microbiome on human cancers', Cancer Reports, vol. 6, no. 11, e1924.
Tian, S, Paudel, D, Hao, F, Neupane, R, Castro, R, Patterson, AD, Tiwari, AK, Prabhu, KS & Singh, V 2023, 'Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production', Cancer Reports, vol. 6, no. 11, e1863.
Nettleford, SK, Liao, C, Short, SP, Rossi, RM, Singh, V & Prabhu, KS 2023, 'Selenoprotein W Ameliorates Experimental Colitis and Promotes Intestinal Epithelial Repair', Antioxidants, vol. 12, no. 4, 850.
Sharma, SK, Mohanty, BP, Singh, V, Bansal, MP, Singhal, NK, Sharma, SK & Sandhir, R 2023, 'Trace elements dyshomeostasis in liver and brain of weanling mice under altered dietary selenium conditions', Journal of Trace Elements in Medicine and Biology, vol. 80, 127305.


Bachu, RD, Abou-Dahech, M, Balaji, S, Boddu, SHS, Amos, S, Singh, V, Babu, RJ & Tiwari, AK 2022, 'Oncology biosimilars: New developments and future directions', Cancer Reports, vol. 5, no. 11, e1720.
Agarwal, H, Sukka, SR, Singh, V, Dikshit, M & Barthwal, MK 2022, 'Standardized fraction of Xylocarpus moluccensis inhibits inflammation by modulating MAPK-NFκB and ROS-HIF1α-PKM2 activation', Inflammation Research, vol. 71, no. 4, pp. 423-437.
Aggarwal, H, Pathak, P, Singh, V, Kumar, Y, Shankar, M, Das, B, Jagavelu, K & Dikshit, M 2022, 'Vancomycin-Induced Modulation of Gram-Positive Gut Bacteria and Metabolites Remediates Insulin Resistance in iNOS Knockout Mice', Frontiers in Cellular and Infection Microbiology, vol. 11, 795333.


Lee, LH, Wong, SH, Chin, SF, Singh, V & Ab Mutalib, NS 2021, 'Editorial: Human Microbiome: Symbiosis to Pathogenesis', Frontiers in Microbiology, vol. 12, 605783.
Sagar, P, Singh, V, Gupta, R, Kaul, S, Sharma, S, Kaur, S, Bhunia, RK, Kondepudi, KK & Singhal, NK 2021, 'PH-Triggered, Synbiotic Hydrogel Beads for in Vivo Therapy of Iron Deficiency Anemia and Reduced Inflammatory Response', ACS Applied Bio Materials, vol. 4, no. 10, pp. 7467-7484.


Singh, V & Kumar, MV 2020, 'Beneficial and detrimental effects of processed dietary fibers on intestinal and liver health: Health benefits of refined dietary fibers need to be redefined!', Gastroenterology Report, vol. 8, no. 2, pp. 85-89.
Singh, V, Galla, S, Golonka, RM, Patterson, AD, Chassaing, B, Joe, B & Vijay-Kumar, M 2020, 'Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice', Physiological genomics, vol. 52, no. 8, pp. 314-321.
Nettleford, SK, Zhao, L, Qian, F, Herold, M, Arner, B, Desai, D, Amin, S, Xiong, N, Singh, V, Carlson, BA & Prabhu, KS 2020, 'The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation', Frontiers in Nutrition, vol. 7, 96.
Singh, V, Gowda, CP, Singh, V, Ganapathy, AS, Karamchandani, DM, Eshelman, MA, Yochum, GS, Nighot, P & Spiegelman, VS 2020, 'The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating Occludin expression', Journal of Biological Chemistry, vol. 295, no. 25, pp. 8602-8612.
Singh, V, Yeoh, BS, Abokor, AA, Golonka, RM, Tian, Y, Patterson, AD, Joe, B, Heikenwalder, M & Vijay-Kumar, M 2020, 'Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota', Gut microbes, vol. 11, no. 4, pp. 1077-1091.