Researcher Profile

Researcher Profile

Vishal Singh

Vishal Singh

Assistant Professor, Nutritional Sciences
Scientific Program:Mechanisms of Carcinogenesis
vxs28@psu.edu

Research Interests

  • Inflammation
  • Lipocalin-2
  • Microbiota
  • Gastrointestinal Microbiome
  • Diet
  • Colitis
  • Atherosclerosis
  • Cholesterol
  • Liver
  • turmeric extract
  • Interleukin-1
  • Macrophages

Recent Publications

2022

Agarwal, H, Sukka, SR, Singh, V, Dikshit, M & Barthwal, MK 2022, 'Standardized fraction of Xylocarpus moluccensis inhibits inflammation by modulating MAPK-NFκB and ROS-HIF1α-PKM2 activation', Inflammation Research, vol. 71, no. 4, pp. 423-437. https://doi.org/10.1007/s00011-022-01549-3
Aggarwal, H, Pathak, P, Singh, V, Kumar, Y, Shankar, M, Das, B, Jagavelu, K & Dikshit, M 2022, 'Vancomycin-Induced Modulation of Gram-Positive Gut Bacteria and Metabolites Remediates Insulin Resistance in iNOS Knockout Mice', Frontiers in Cellular and Infection Microbiology, vol. 11, 795333. https://doi.org/10.3389/fcimb.2021.795333

2021

Lee, LH, Wong, SH, Chin, SF, Singh, V & Ab Mutalib, NS 2021, 'Editorial: Human Microbiome: Symbiosis to Pathogenesis', Frontiers in Microbiology, vol. 12, 605783. https://doi.org/10.3389/fmicb.2021.605783
Sagar, P, Singh, V, Gupta, R, Kaul, S, Sharma, S, Kaur, S, Bhunia, RK, Kondepudi, KK & Singhal, NK 2021, 'PH-Triggered, Synbiotic Hydrogel Beads for in Vivo Therapy of Iron Deficiency Anemia and Reduced Inflammatory Response', ACS Applied Bio Materials, vol. 4, no. 10, pp. 7467-7484. https://doi.org/10.1021/acsabm.1c00720

2020

Singh, V & Vijay-Kumar, M 2020, 'Beneficial and detrimental effects of processed dietary fibers on intestinal and liver health: Health benefits of refined dietary fibers need to be redefined!', Gastroenterology Report, vol. 8, no. 2, pp. 85-89. https://doi.org/10.1093/gastro/goz072
Singh, V, Galla, S, Golonka, RM, Patterson, AD, Chassaing, B, Joe, B & Vijay-Kumar, M 2020, 'Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice', Physiological genomics, vol. 52, no. 8, pp. 314-321. https://doi.org/10.1152/physiolgenomics.00118.2019
Nettleford, SK, Zhao, L, Qian, F, Herold, M, Arner, B, Desai, D, Amin, S, Xiong, N, Singh, V, Carlson, BA & Prabhu, KS 2020, 'The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation', Frontiers in Nutrition, vol. 7, 96. https://doi.org/10.3389/fnut.2020.00096
Singh, V, Gowda, CP, Singh, V, Ganapathy, AS, Karamchandani, DM, Eshelman, MA, Yochum, GS, Nighot, P & Spiegelman, VS 2020, 'The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating Occludin expression', Journal of Biological Chemistry, vol. 295, no. 25, pp. 8602-8612. https://doi.org/10.1074/jbc.ac120.013646
Singh, V, Yeoh, BS, Abokor, AA, Golonka, RM, Tian, Y, Patterson, AD, Joe, B, Heikenwalder, M & Vijay-Kumar, M 2020, 'Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota', Gut microbes, vol. 11, no. 4, pp. 1077-1091. https://doi.org/10.1080/19490976.2020.1743492

2019

Singh, A, Singh, V, Tiwari, RL, Chandra, T, Kumar, A, Dikshit, M & Barthwal, MK 2019, 'Correction to: The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes (Cellular & Molecular Immunology, (2016), 13, 6, (745-763), 10.1038/cmi.2015.62)', Cellular and Molecular Immunology, vol. 16, no. 12, pp. 946. https://doi.org/10.1038/s41423-019-0286-1
Singh, V, Yeoh, BS, Walker, RE, Xiao, X, Saha, P, Golonka, RM, Cai, J, Bretin, ACA, Cheng, X, Liu, Q, Flythe, MD, Chassaing, B, Shearer, GC, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2019, 'Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation', Gut, vol. 68, no. 10, pp. 1801-1812. https://doi.org/10.1136/gutjnl-2018-316250
Saha, P, Yeoh, BS, Xiao, X, Golonka, RM, Singh, V, Wang, Y & Vijay-Kumar, M 2019, 'PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium', Mucosal Immunology, vol. 12, no. 3, pp. 761-771. https://doi.org/10.1038/s41385-019-0139-3

2018

Singh, V, Yeoh, BS, Chassaing, B, Xiao, X, Saha, P, Aguilera Olvera, R, Lapek, JD, Zhang, L, Wang, WB, Hao, S, Flythe, MD, Gonzalez, DJ, Cani, PD, Conejo-Garcia, JR, Xiong, N, Kennett, MJ, Joe, B, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2018, 'Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer', Cell, vol. 175, no. 3, pp. 679-694.e22. https://doi.org/10.1016/j.cell.2018.09.004
Xiao, X, Saha, P, Yeoh, BS, Hipp, JA, Singh, V & Vijay-Kumar, M 2018, 'Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects', Journal of Nutritional Biochemistry, vol. 62, pp. 28-34. https://doi.org/10.1016/j.jnutbio.2018.08.003
Chakraborty, S, Galla, S, Cheng, X, Yeo, JY, Mell, B, Singh, V, Yeoh, BS, Saha, P, Mathew, AV, Vijay-Kumar, M & Joe, B 2018, 'Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension', Cell Reports, vol. 25, no. 3, pp. 677-689.e4. https://doi.org/10.1016/j.celrep.2018.09.058
Kanshana, JS, Rebello, SC, Pathak, P, Kanuri, BN, Aggarwal, H, Srivastava, V, Khanna, V, Singh, V, Jagavelu, K, Barthwal, MK & Dikshit, M 2018, 'Standardized fraction of Xylocarpus moluccensis fruits improve vascular relaxation and plaque stability in dyslipidemic models of atherosclerosis', Journal of Ethnopharmacology, vol. 213, pp. 81-91. https://doi.org/10.1016/j.jep.2017.11.004

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)