Researcher Profile

Researcher Profile

Vishal Singh

Vishal Singh

Assistant Professor, Nutritional Sciences
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Inflammation
  • Microbiota
  • Diet
  • Atherosclerosis
  • Colitis
  • Cholesterol
  • Interleukin-1
  • Monocytes
  • Macrophages
  • Homeostasis
  • Siderophores
  • Liver

Recent Publications


Singh, A, Singh, V, Tiwari, RL, Chandra, T, Kumar, A, Dikshit, M & Barthwal, MK 2019, 'Correction to: The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes (Cellular & Molecular Immunology, (2016), 13, 6, (745-763), 10.1038/cmi.2015.62)', Cellular and Molecular Immunology, vol. 16, no. 12.
Singh, V, Yeoh, BS, Walker, RE, Xiao, X, Saha, P, Golonka, RM, Cai, J, Bretin, ACA, Cheng, X, Liu, Q, Flythe, MD, Chassaing, B, Shearer, GC, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2019, 'Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation', Gut, vol. 68, no. 10, pp. 1801-1812.
Saha, P, Yeoh, BS, Xiao, X, Golonka, RM, Singh, V, Wang, Y & Vijay-Kumar, M 2019, 'PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium', Mucosal Immunology, vol. 12, no. 3, pp. 761-771.


Singh, V, Yeoh, BS, Chassaing, B, Xiao, X, Saha, P, Aguilera Olvera, R, Lapek, JD, Zhang, L, Wang, WB, Hao, S, Flythe, MD, Gonzalez, DJ, Cani, PD, Conejo-Garcia, JR, Xiong, N, Kennett, MJ, Joe, B, Patterson, AD, Gewirtz, AT & Vijay-Kumar, M 2018, 'Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer', Cell, vol. 175, no. 3, pp. 679-694.e22.
Xiao, X, Saha, P, Yeoh, BS, Hipp, JA, Singh, V & Vijay-Kumar, M 2018, 'Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects', Journal of Nutritional Biochemistry, vol. 62, pp. 28-34.
Chakraborty, S, Galla, S, Cheng, X, Yeo, JY, Mell, B, Singh, V, Yeoh, BS, Saha, P, Mathew, AV, Vijay-Kumar, M & Joe, B 2018, 'Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension', Cell Reports, vol. 25, no. 3, pp. 677-689.e4.
Kanshana, JS, Rebello, SC, Pathak, P, Kanuri, BN, Aggarwal, H, Srivastava, V, Khanna, V, Singh, V, Jagavelu, K, Barthwal, MK & Dikshit, M 2018, 'Standardized fraction of Xylocarpus moluccensis fruits improve vascular relaxation and plaque stability in dyslipidemic models of atherosclerosis', Journal of Ethnopharmacology, vol. 213, pp. 81-91.


Saha, P, Yeoh, BS, Olvera, RA, Xiao, X, Singh, V, Awasthi, D, Subramanian, BC, Chen, Q, Dikshit, M, Wang, Y, Parent, CA & Vijay-Kumar, M 2017, 'Bacterial siderophores hijack neutrophil functions', Journal of Immunology, vol. 198, no. 11, pp. 4293-4303.
Singh, V, Yeoh, BS, Nilsen-Hamilton, M, Berger, T, Mak, TW & Vijay-Kumar, M 2017, 'Data on IL-10R neutralization-induced chronic colitis in Lipocalin 2 deficient mice on BALB/c background', Data in Brief, vol. 11, pp. 588-592.
Saha, P, Chassaing, B, Yeoh, BS, Viennois, E, Xiao, X, Kennett, MJ, Singh, V & Vijay-Kumar, M 2017, 'Ectopic Expression of Innate Immune Protein, Lipocalin-2, in Lactococcus lactis Protects Against Gut and Environmental Stressors', Inflammatory bowel diseases, vol. 23, no. 7, pp. 1120-1132.
Zou, J, Chassaing, B, Singh, V, Pellizzon, M, Ricci, M, Fythe, MD, Kumar, MV & Gewirtz, AT 2018, 'Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health', Cell Host and Microbe, vol. 23, no. 1, pp. 41-53.e4.
Xiao, X, Yeoh, BS, Saha, P, Tian, Y, Singh, V, Patterson, AD & Vijay-Kumar, M 2017, 'Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice', Journal of Nutritional Biochemistry, vol. 41, pp. 25-33.
Kanshana, JS, Khanna, V, Singh, V, Jain, M, Misra, A, Kumar, S, Farooqui, M, Barthwal, MK & Dikshit, M 2017, 'Progression and Characterization of the Accelerated Atherosclerosis in Iliac Artery of New Zealand White Rabbits: Effect of Simvastatin', Journal of Cardiovascular Pharmacology, vol. 69, no. 5, pp. 314-325.


Rana, M, Maurya, P, Reddy, SS, Singh, V, Ahmad, H, Dwivedi, AK, Dikshit, M & Barthwal, MK 2016, 'A standardized chemically modified Curcuma longa extract modulates IRAK-MAPK signaling in inflammation and potentiates cytotoxicity', Frontiers in Pharmacology, vol. 7, no. JUL, 223.
Saha, P, Singh, V, Xiao, X, Yeoh, BS & Kumar, MV 2016, 'Data on importance of hematopoietic cell derived Lipocalin 2 against gut inflammation', Data in Brief, vol. 8, pp. 812-816.
Yeoh, BS, Saha, P, Singh, V, Xiao, X, Ying, Y, Vanamala, JK, Kennett, MJ, Harvatine, KJ, Joe, B & Vijay-Kumar, M 2016, 'Deficiency of stearoyl-CoA desaturase-1 aggravates colitogenic potential of adoptively transferred effector T cells', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 311, no. 4, pp. G713-G723.
Yeoh, BS, Aguilera Olvera, R, Singh, V, Xiao, X, Kennett, MJ, Joe, B, Lambert, JD & Vijay-Kumar, M 2016, 'Epigallocatechin-3-gallate inhibition of myeloperoxidase and its counter-regulation by dietary iron and lipocalin 2 in murine model of gut inflammation', American Journal of Pathology, vol. 186, no. 4, pp. 912-926.
Singh, V, Yeoh, BS & Vijay-Kumar, M 2016, 'Feed your gut with caution!', Translational Cancer Research, vol. 5, pp. S507-S513.
Jain, M, Singh, A, Singh, V, Maurya, P & Barthwal, MK 2016, 'Gingerol Inhibits Serum-Induced Vascular Smooth Muscle Cell Proliferation and Injury-Induced Neointimal Hyperplasia by Suppressing p38 MAPK Activation', Journal of Cardiovascular Pharmacology and Therapeutics, vol. 21, no. 2, pp. 187-200.
Singh, V, Yeoh, BS & Kumar, MV 2016, 'Gut microbiome as a novel cardiovascular therapeutic target', Current Opinion in Pharmacology, vol. 27, pp. 8-12.
Rana, M, Kumar, A, Tiwari, RL, Singh, V, Chandra, T, Dikshit, M & Barthwal, MK 2016, 'IRAK regulates macrophage foam cell formation by modulating genes involved in cholesterol uptake and efflux', BioEssays, vol. 38, no. 7, pp. 591-604.
Singh, V, Kumar, M, San Yeoh, B, Xiao, X, Saha, P, Kennett, MJ & Vijay-Kumar, M 2016, 'Inhibition of interleukin-10 signaling induces microbiota-dependent chronic colitis in Apolipoprotein E deficient mice', Inflammatory bowel diseases, vol. 22, no. 4, pp. 841-852.
Xiao, X, Yeoh, BS, Saha, P, Olvera, RA, Singh, V & Kumar, MV 2016, 'Lipocalin 2 alleviates iron toxicity by facilitating hypoferremia of inflammation and limiting catalytic iron generation', BioMetals, vol. 29, no. 3, pp. 451-465.
Singh, V, Yeoh, BS, Chassaing, B, Zhang, B, Saha, P, Xiao, X, Awasthi, D, Shashidharamurthy, R, Dikshit, M, Gewirtz, A & Vijay-Kumar, M 2016, 'Microbiota-Inducible Innate Immune Siderophore Binding Protein Lipocalin 2 Is Critical for Intestinal Homeostasis', CMGH, vol. 2, no. 4, pp. 482-498.e6.
Singh, A, Singh, V, Tiwari, RL, Chandra, T, Kumar, A, Dikshit, M & Barthwal, MK 2016, 'The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes', Cellular and Molecular Immunology, vol. 13, no. 6, pp. 747-763.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)