Researcher Profile

Researcher Profile

Hua Tian

Hua Tian

Research Associate, Chemistry
Scientific Program:Mechanisms of Carcinogenesis
hut3@psu.edu

Research Interests

  • Secondary Ion Mass Spectrometry
  • Ions
  • Gases
  • Lipids
  • Nanoparticles
  • Gold
  • Trehalose
  • Xenopus laevis
  • poly(styrene-alt-maleic anhydride)
  • 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide
  • Argon
  • Irganox 1010

Recent Publications

2020

Pareek, V, Tian, H, Winograd, N & Benkovic, SJ 2020, 'Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells', Science, vol. 368, no. 6488, pp. 283-290. https://doi.org/10.1126/science.aaz6465

2019

Tian, H, Maciążek, D, Postawa, Z, Garrison, BJ & Winograd, N 2019, 'C-O Bond Dissociation and Induced Chemical Ionization Using High Energy (CO2)n+ Gas Cluster Ion Beam', Journal of the American Society for Mass Spectrometry, vol. 30, no. 3, pp. 476-481. https://doi.org/10.1007/s13361-018-2102-z
Sheraz, S, Tian, H, Vickerman, JC, Blenkinsopp, P, Winograd, N & Cumpson, P 2019, 'Enhanced Ion Yields Using High Energy Water Cluster Beams for Secondary Ion Mass Spectrometry Analysis and Imaging', Analytical chemistry, vol. 91, no. 14, pp. 9058-9068. https://doi.org/10.1021/acs.analchem.9b01390
Breuer, L, Tian, H, Wucher, A & Winograd, N 2019, 'Molecular SIMS Ionization Probability Studied with Laser Postionization: Influence of the Projectile Cluster', Journal of Physical Chemistry C, vol. 123, no. 1, pp. 565-574. https://doi.org/10.1021/acs.jpcc.8b10245
Tian, H, Sparvero, LJ, Blenkinsopp, P, Amoscato, AA, Watkins, SC, Bayır, H, Kagan, VE & Winograd, N 2019, 'Secondary-Ion Mass Spectrometry Images Cardiolipins and Phosphatidylethanolamines at the Subcellular Level', Angewandte Chemie - International Edition, vol. 58, no. 10, pp. 3156-3161. https://doi.org/10.1002/anie.201814256

2017

Tian, H, Sparvero, LJ, Amoscato, AA, Bloom, A, Baylr, H, Kagan, VE & Winograd, N 2017, 'Gas Cluster Ion Beam Time-of-Flight Secondary Ion Mass Spectrometry High-Resolution Imaging of Cardiolipin Speciation in the Brain: Identification of Molecular Losses after Traumatic Injury', Analytical chemistry, vol. 89, no. 8, pp. 4611-4619. https://doi.org/10.1021/acs.analchem.7b00164
Bloom, AN, Tian, H, Schoen, C & Winograd, N 2017, 'Label-free visualization of nilotinib-functionalized gold nanoparticles within single mammalian cells by C60- SIMS imaging', Analytical and Bioanalytical Chemistry, vol. 409, no. 12, pp. 3067-3076. https://doi.org/10.1007/s00216-017-0262-5
Tian, H, Six, DA, Krucker, T, Leeds, JA & Winograd, N 2017, 'Subcellular Chemical Imaging of Antibiotics in Single Bacteria Using C60-Secondary Ion Mass Spectrometry', Analytical chemistry, vol. 89, no. 9, pp. 5050-5057. https://doi.org/10.1021/acs.analchem.7b00466

2016

Bloom, AN, Tian, H & Winograd, N 2016, 'C60-SIMS imaging of nanoparticles within mammalian cells', Biointerphases, vol. 11, no. 2, pp. 1-7. https://doi.org/10.1116/1.4939463
Tian, H, Maciążek, D, Postawa, Z, Garrison, BJ & Winograd, N 2016, 'CO2 Cluster Ion Beam, an Alternative Projectile for Secondary Ion Mass Spectrometry', Journal of the American Society for Mass Spectrometry, vol. 27, no. 9, pp. 1476-1482. https://doi.org/10.1007/s13361-016-1423-z
Tian, H, Wucher, A & Winograd, N 2016, 'Dynamic Reactive Ionization with Cluster Secondary Ion Mass Spectrometry', Journal of the American Society for Mass Spectrometry, vol. 27, no. 2, pp. 285-292. https://doi.org/10.1007/s13361-015-1283-y
Tian, H, Wucher, A & Winograd, N 2016, 'Reduce the matrix effect in biological tissue imaging using dynamic reactive ionization and gas cluster ion beams', Biointerphases, vol. 11, no. 2, 02A320. https://doi.org/10.1116/1.4941366
Tian, H, Wucher, A & Winograd, N 2016, 'Reducing the Matrix Effect in Organic Cluster SIMS Using Dynamic Reactive Ionization', Journal of the American Society for Mass Spectrometry, vol. 27, no. 12, pp. 2014-2024. https://doi.org/10.1007/s13361-016-1492-z

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)