Researcher Profile

Researcher Profile

Claudia Nicolae, PhD

Claudia Nicolae, PhD

Assistant Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Next-Generation Therapies

Research Interests

  • Neoplasms
  • DNA Damage
  • DNA Repair
  • Genomic Instability
  • Matrilin Proteins
  • DNA Replication
  • Proliferating Cell Nuclear Antigen
  • DNA
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Mutation
  • Cell Proliferation
  • Proteins

Recent Publications


Abu-Libdeh, B, Jhujh, SS, Dhar, S, Sommers, JA, Datta, A, Longo, GMC, Grange, LJ, Reynolds, JJ, Cooke, SL, McNee, GS, Hollingworth, R, Woodward, BL, Ganesh, AN, Smerdon, SJ, Nicolae, CM, Durlacher-Betzer, K, Molho-Pessach, V, Abu-Libdeh, A, Meiner, V, Moldovan, GL, Roukos, V, Harel, T, Brosh, RM & Stewart, GS 2022, 'RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1', Journal of Clinical Investigation, vol. 132, no. 5, e147301.
Schleicher, EM, Dhoonmoon, A, Jackson, LM, Khatib, JB, Nicolae, CM & Moldovan, GL 2022, 'The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells', Oncogenesis, vol. 11, no. 1, 33.
Hirschler-Laszkiewicz, I, Festa, F, Huang, S, Moldovan, GL, Nicolae, C, Dhoonmoon, A, Bao, L, Keefer, K, Chen, SJ, Wang, HG, Cheung, JY & Miller, BA 2022, 'The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1', Scientific reports, vol. 12, no. 1, 6311.


Jackson, LM, Dhoonmoon, A, Hale, A, Dennis, KA, Schleicher, EM, Nicolae, CM & Moldovan, GL 2021, 'Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells', Nucleic acids research, vol. 49, no. 22, pp. 12855-12869.
O’Connor, MJ, Thakar, T, Nicolae, CM & Moldovan, GL 2021, 'PARP14 regulates cyclin D1 expression to promote cell-cycle progression', Oncogene, vol. 40, no. 30, pp. 4872-4883.
Datta, A, Biswas, K, Sommers, JA, Thompson, H, Awate, S, Nicolae, CM, Thakar, T, Moldovan, GL, Shoemaker, RH, Sharan, SK & Brosh, RM 2021, 'WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells', Nature communications, vol. 12, no. 1, 6561.


Schleicher, EM, Dhoonmoon, A, Jackson, LM, Clements, KE, Stump, CL, Nicolae, CM & Moldovan, GL 2020, 'Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors', PLoS genetics, vol. 16, no. 11, e1009176.
Awate, S, Sommers, JA, Datta, A, Nayak, S, Bellani, MA, Yang, O, Dunn, CA, Nicolae, CM, Moldovan, GL, Seidman, MM, Cantor, SB & Brosh, RM 2020, 'FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links', Nucleic acids research, vol. 48, no. 16, pp. 9161-9180.
Dhoonmoon, A, Schleicher, EM, Clements, KE, Nicolae, CM & Moldovan, GL 2020, 'Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR', Nucleic acids research, vol. 48, no. 13, pp. 7252-7264.
Clements, KE, Schleicher, EM, Thakar, T, Hale, A, Dhoonmoon, A, Tolman, NJ, Sharma, A, Liang, X, Imamura Kawasawa, Y, Nicolae, CM, Wang, HG, De, S & Moldovan, GL 2020, 'Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens', Nature communications, vol. 11, no. 1, 6118.
Li, P, Fleischhauer, L, Nicolae, C, Prein, C, Farkas, Z, Saller, MM, Prall, WC, Wagener, R, Heilig, J, Niehoff, A, Clausen-Schaumann, H, Alberton, P & Aszodi, A 2020, 'Mice lacking the matrilin family of extracellular matrix proteins develop mild skeletal abnormalities and are susceptible to age-associated osteoarthritis', International journal of molecular sciences, vol. 21, no. 2, 666.
Thakar, T, Leung, W, Nicolae, CM, Clements, KE, Shen, B, Bielinsky, AK & Moldovan, GL 2020, 'Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly', Nature communications, vol. 11, no. 1, 2147.


Naldiga, S, Ji, S, Thomforde, J, Nicolae, CM, Lee, M, Zhang, Z, Moldovan, GL, Tretyakova, NY & Basu, AK 2019, 'Error-prone replication of a 5-formylcytosine-mediated DNA-peptide cross-link in human cells', Journal of Biological Chemistry, vol. 294, no. 27, pp. 10619-10627.
Edvardson, S, Nicolae, CM, Noh, GJ, Burton, JE, Punzi, G, Shaag, A, Bischetsrieder, J, De Grassi, A, Pierri, CL, Elpeleg, O & Moldovan, GL 2019, 'Heterozygous RNF13 Gain-of-Function Variants Are Associated with Congenital Microcephaly, Epileptic Encephalopathy, Blindness, and Failure to Thrive', American Journal of Human Genetics, vol. 104, no. 1, pp. 179-185.
Nicolae, CM, O’Connor, MJ, Schleicher, EM, Song, C, Gowda, R, Robertson, G, Dovat, S & Moldovan, GL 2019, 'PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells', Oncogene, vol. 38, no. 27, pp. 5530-5540.
Ranoa, DRE, Widau, RC, Mallon, S, Parekh, AD, Nicolae, CM, Huang, X, Bolt, MJ, Arina, A, Parry, R, Kron, SJ, Moldovan, GL, Khodarev, NN & Weichselbaum, RR 2019, 'STING promotes homeostasis via regulation of cell proliferation and chromosomal stability', Cancer Research, vol. 79, no. 7, pp. 1465-1479.


Clements, KE, Thakar, T, Nicolae, CM, Liang, X, Wang, HG & Moldovan, GL 2018, 'Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells', Nucleic acids research, vol. 46, no. 17, pp. 8898-8907.
Nicolae, CM, O'connor, MJ, Constantin, D & Moldovan, GL 2018, 'NFκB regulates p21 expression and controls DNA damage-induced leukemic differentiation', Oncogene, vol. 37, no. 27, pp. 3647-3656.
Schleicher, EM, Galvan, AM, Imamura-Kawasawa, Y, Moldovan, GL & Nicolae, CM 2018, 'PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress', Nucleic acids research, vol. 46, no. 17, pp. 8908-8916.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)