Researcher Profile

Researcher Profile

Claudia Nicolae, PhD

Claudia Nicolae, PhD

Assistant Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Next-Generation Therapies

Research Interests

  • Matrilin Proteins
  • Neoplasms
  • DNA Repair
  • DNA Damage
  • Cell Proliferation
  • Proliferating Cell Nuclear Antigen
  • Extracellular Matrix Proteins
  • DNA Replication
  • Mutation
  • Genomic Instability
  • Collagen
  • DNA

Recent Publications


Li, P, Fleischhauer, L, Nicolae, C, Prein, C, Farkas, Z, Saller, MM, Prall, WC, Wagener, R, Heilig, J, Niehoff, A, Clausen-Schaumann, H, Alberton, P & Aszodi, A 2020, 'Mice lacking the matrilin family of extracellular matrix proteins develop mild skeletal abnormalities and are susceptible to age-associated osteoarthritis', International journal of molecular sciences, vol. 21, no. 2, 666.


Naldiga, S, Ji, S, Thomforde, J, Nicolae, CM, Lee, M, Zhang, Z, Moldovan, GL, Tretyakova, NY & Basu, AK 2019, 'Error-prone replication of a 5-formylcytosine-mediated DNA-peptide cross-link in human cells', Journal of Biological Chemistry, vol. 294, no. 27, pp. 10619-10627.
Edvardson, S, Nicolae, CM, Noh, GJ, Burton, JE, Punzi, G, Shaag, A, Bischetsrieder, J, De Grassi, A, Pierri, CL, Elpeleg, O & Moldovan, GL 2019, 'Heterozygous RNF13 Gain-of-Function Variants Are Associated with Congenital Microcephaly, Epileptic Encephalopathy, Blindness, and Failure to Thrive', American Journal of Human Genetics, vol. 104, no. 1, pp. 179-185.
Nicolae, CM, O’Connor, MJ, Schleicher, EM, Song, C, Gowda, R, Robertson, G, Dovat, S & Moldovan, GL 2019, 'PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells', Oncogene, vol. 38, no. 27, pp. 5530-5540.
Ranoa, DRE, Widau, RC, Mallon, S, Parekh, AD, Nicolae, CM, Huang, X, Bolt, MJ, Arina, A, Parry, R, Kron, SJ, Moldovan, GL, Khodarev, NN & Weichselbaum, RR 2019, 'STING promotes homeostasis via regulation of cell proliferation and chromosomal stability', Cancer Research, vol. 79, no. 7, pp. 1465-1479.


Clements, KE, Thakar, T, Nicolae, CM, Liang, X, Wang, HG & Moldovan, GL 2018, 'Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells', Nucleic acids research, vol. 46, no. 17, pp. 8898-8907.
Nicolae, CM, O'connor, MJ, Constantin, D & Moldovan, GL 2018, 'NFκB regulates p21 expression and controls DNA damage-induced leukemic differentiation', Oncogene, vol. 37, no. 27, pp. 3647-3656.
Schleicher, EM, Galvan, AM, Imamura-Kawasawa, Y, Moldovan, GL & Nicolae, CM 2018, 'PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress', Nucleic acids research, vol. 46, no. 17, pp. 8908-8916.


Edvardson, S, Nicolae, CM, Agrawal, PB, Mignot, C, Payne, K, Prasad, AN, Prasad, C, Sadler, L, Nava, C, Mullen, TE, Begtrup, A, Baskin, B, Powis, Z, Shaag, A, Keren, B, Moldovan, GL & Elpeleg, O 2017, 'Heterozygous De Novo UBTF Gain-of-Function Variant Is Associated with Neurodegeneration in Childhood', American Journal of Human Genetics, vol. 101, no. 2, pp. 267-273.


Nicolae, CM & Moldovan, GL 2016, 'ERKing Trypanosoma: PCNA phosphorylation as novel target', Cell Cycle, vol. 15, no. 23, pp. 3167-3168.
Shahrour, MA, Nicolae, CM, Edvardson, S, Ashhab, M, Galvan, AM, Constantin, D, Abu-Libdeh, B, Moldovan, GL & Elpeleg, O 2017, 'Erratum to: PARP10 deficiency manifests by severe developmental delay and DNA repair defect (Neurogenetics, (2016), 17, (227-232), 10.1007/s10048-016-0493-1)', Neurogenetics, vol. 18, no. 1.
Uckelmann, H, Blaszkiewicz, S, Nicolae, C, Haas, S, Schnell, A, Wurzer, S, Wagener, R, Aszodi, A & Essers, MAG 2016, 'Extracellular matrix protein Matrilin-4 regulates stressinduced HSC proliferation via CXCR4', Journal of Experimental Medicine, vol. 213, no. 10, pp. 1961-1971.
Choe, KN, Nicolae, CM, Constantin, D, Imamura Kawasawa, Y, Delgado-Diaz, MR, De, S, Freire, R, Smits, VA & Moldovan, GL 2016, 'HUWE1 interacts with PCNA to alleviate replication stress', EMBO Reports, vol. 17, no. 6, pp. 874-886.
Shahrour, MA, Nicolae, CM, Edvardson, S, Ashhab, M, Galvan, AM, Constantin, D, Abu-Libdeh, B, Moldovan, GL & Elpeleg, O 2016, 'PARP10 deficiency manifests by severe developmental delay and DNA repair defect', Neurogenetics, vol. 17, no. 4, pp. 227-232.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)