Navigation Menu

Clinical Trial External Search

Children (age < 18 years)
Adults (age >= 18 years)

Researcher Profile

Researcher Display

Claudia Nicolae, PhD

Claudia Nicolae, PhD

Assistant Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Next-Generation Therapies

Research Interests

  • Neoplasms
  • DNA Damage
  • DNA Repair
  • Genomic Instability
  • DNA Replication
  • Proliferating Cell Nuclear Antigen
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • DNA
  • Matrilin Proteins
  • Genome
  • ADP Ribose Transferases
  • Mutation

Recent Publications


Nusawardhana, A, Pale, LM, Nicolae, CM & Moldovan, GL 2024, 'USP1-dependent nucleolytic expansion of PRIMPOL-generated nascent DNA strand discontinuities during replication stress', Nucleic acids research, vol. 52, no. 5, pp. 2340-2354.


Dhoonmoon, A & Nicolae, CM 2023, 'Mono-ADP-ribosylation by PARP10 and PARP14 in genome stability', NAR Cancer, vol. 5, no. 1, zcad009.
Hale, A, Dhoonmoon, A, Straka, J, Nicolae, CM & Moldovan, GL 2023, 'Multi-step processing of replication stress-derived nascent strand DNA gaps by MRE11 and EXO1 nucleases', Nature communications, vol. 14, no. 1, 6265.
Khatib, JB, Nicolae, CM & Moldovan, GL 2024, 'Role of Translesion DNA Synthesis in the Metabolism of Replication-associated Nascent Strand Gaps', Journal of Molecular Biology, vol. 436, no. 1, 168275.


Khatib, JB, Schleicher, EM, Jackson, LM, Dhoonmoon, A, Moldovan, GL & Nicolae, CM 2022, 'Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular survival', Oncotarget, vol. 13, no. 1, pp. 1078-1091.
Thakar, T, Dhoonmoon, A, Straka, J, Schleicher, EM, Nicolae, CM & Moldovan, GL 2022, 'Lagging strand gap suppression connects BRCA-mediated fork protection to nucleosome assembly through PCNA-dependent CAF-1 recycling', Nature communications, vol. 13, no. 1, 5323.
Abu-Libdeh, B, Jhujh, SS, Dhar, S, Sommers, JA, Datta, A, Longo, GMC, Grange, LJ, Reynolds, JJ, Cooke, SL, McNee, GS, Hollingworth, R, Woodward, BL, Ganesh, AN, Smerdon, SJ, Nicolae, CM, Durlacher-Betzer, K, Molho-Pessach, V, Abu-Libdeh, A, Meiner, V, Moldovan, GL, Roukos, V, Harel, T, Brosh, RM & Stewart, GS 2022, 'RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1', Journal of Clinical Investigation, vol. 132, no. 5, e147301.
Dhoonmoon, A, Nicolae, CM & Moldovan, GL 2022, 'The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1', Nature communications, vol. 13, no. 1, 5063.
Schleicher, EM, Dhoonmoon, A, Jackson, LM, Khatib, JB, Nicolae, CM & Moldovan, GL 2022, 'The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells', Oncogenesis, vol. 11, no. 1, 33.
Hirschler-Laszkiewicz, I, Festa, F, Huang, S, Moldovan, GL, Nicolae, C, Dhoonmoon, A, Bao, L, Keefer, K, Chen, SJ, Wang, HG, Cheung, JY & Miller, BA 2022, 'The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1', Scientific reports, vol. 12, no. 1, 6311.


Jackson, LM, Dhoonmoon, A, Hale, A, Dennis, KA, Schleicher, EM, Nicolae, CM & Moldovan, GL 2021, 'Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells', Nucleic acids research, vol. 49, no. 22, pp. 12855-12869.
O’Connor, MJ, Thakar, T, Nicolae, CM & Moldovan, GL 2021, 'PARP14 regulates cyclin D1 expression to promote cell-cycle progression', Oncogene, vol. 40, no. 30, pp. 4872-4883.
Datta, A, Biswas, K, Sommers, JA, Thompson, H, Awate, S, Nicolae, CM, Thakar, T, Moldovan, GL, Shoemaker, RH, Sharan, SK & Brosh, RM 2021, 'WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells', Nature communications, vol. 12, no. 1, 6561.


Schleicher, EM, Dhoonmoon, A, Jackson, LM, Clements, KE, Stump, CL, Nicolae, CM & Moldovan, GL 2020, 'Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors', PLoS genetics, vol. 16, no. 11, e1009176.
Awate, S, Sommers, JA, Datta, A, Nayak, S, Bellani, MA, Yang, O, Dunn, CA, Nicolae, CM, Moldovan, GL, Seidman, MM, Cantor, SB & Brosh, RM 2020, 'FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links', Nucleic acids research, vol. 48, no. 16, pp. 9161-9180.
Dhoonmoon, A, Schleicher, EM, Clements, KE, Nicolae, CM & Moldovan, GL 2020, 'Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR', Nucleic acids research, vol. 48, no. 13, pp. 7252-7264.
Clements, KE, Schleicher, EM, Thakar, T, Hale, A, Dhoonmoon, A, Tolman, NJ, Sharma, A, Liang, X, Imamura Kawasawa, Y, Nicolae, CM, Wang, HG, De, S & Moldovan, GL 2020, 'Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens', Nature communications, vol. 11, no. 1, 6118.
Li, P, Fleischhauer, L, Nicolae, C, Prein, C, Farkas, Z, Saller, MM, Prall, WC, Wagener, R, Heilig, J, Niehoff, A, Clausen-Schaumann, H, Alberton, P & Aszodi, A 2020, 'Mice lacking the matrilin family of extracellular matrix proteins develop mild skeletal abnormalities and are susceptible to age-associated osteoarthritis', International journal of molecular sciences, vol. 21, no. 2, 666.
Thakar, T, Leung, W, Nicolae, CM, Clements, KE, Shen, B, Bielinsky, AK & Moldovan, GL 2020, 'Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly', Nature communications, vol. 11, no. 1, 2147.