Researcher Profile

Researcher Profile

Claudia Nicolae, PhD

Claudia Nicolae, PhD

Assistant Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Next-Generation Therapies

Research Interests

  • Matrilin Proteins
  • DNA Damage
  • Neoplasms
  • DNA Repair
  • Proliferating Cell Nuclear Antigen
  • Cell Proliferation
  • DNA Replication
  • Extracellular Matrix Proteins
  • Mutation
  • Genomic Instability
  • DNA
  • Collagen

Recent Publications


Li, P, Fleischhauer, L, Nicolae, C, Prein, C, Farkas, Z, Saller, MM, Prall, WC, Wagener, R, Heilig, J, Niehoff, A, Clausen-Schaumann, H, Alberton, P & Aszodi, A 2020, 'Mice lacking the matrilin family of extracellular matrix proteins develop mild skeletal abnormalities and are susceptible to age-associated osteoarthritis', International journal of molecular sciences, vol. 21, no. 2, 666.
Thakar, T, Leung, W, Nicolae, CM, Clements, KE, Shen, B, Bielinsky, AK & Moldovan, GL 2020, 'Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly', Nature communications, vol. 11, no. 1, 2147.


Naldiga, S, Ji, S, Thomforde, J, Nicolae, CM, Lee, M, Zhang, Z, Moldovan, GL, Tretyakova, NY & Basu, AK 2019, 'Error-prone replication of a 5-formylcytosine-mediated DNA-peptide cross-link in human cells', Journal of Biological Chemistry, vol. 294, no. 27, pp. 10619-10627.
Edvardson, S, Nicolae, CM, Noh, GJ, Burton, JE, Punzi, G, Shaag, A, Bischetsrieder, J, De Grassi, A, Pierri, CL, Elpeleg, O & Moldovan, GL 2019, 'Heterozygous RNF13 Gain-of-Function Variants Are Associated with Congenital Microcephaly, Epileptic Encephalopathy, Blindness, and Failure to Thrive', American Journal of Human Genetics, vol. 104, no. 1, pp. 179-185.
Nicolae, CM, O’Connor, MJ, Schleicher, EM, Song, C, Gowda, R, Robertson, G, Dovat, S & Moldovan, GL 2019, 'PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells', Oncogene, vol. 38, no. 27, pp. 5530-5540.
Ranoa, DRE, Widau, RC, Mallon, S, Parekh, AD, Nicolae, CM, Huang, X, Bolt, MJ, Arina, A, Parry, R, Kron, SJ, Moldovan, GL, Khodarev, NN & Weichselbaum, RR 2019, 'STING promotes homeostasis via regulation of cell proliferation and chromosomal stability', Cancer Research, vol. 79, no. 7, pp. 1465-1479.


Clements, KE, Thakar, T, Nicolae, CM, Liang, X, Wang, HG & Moldovan, GL 2018, 'Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells', Nucleic acids research, vol. 46, no. 17, pp. 8898-8907.
Nicolae, CM, O'connor, MJ, Constantin, D & Moldovan, GL 2018, 'NFκB regulates p21 expression and controls DNA damage-induced leukemic differentiation', Oncogene, vol. 37, no. 27, pp. 3647-3656.
Schleicher, EM, Galvan, AM, Imamura-Kawasawa, Y, Moldovan, GL & Nicolae, CM 2018, 'PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress', Nucleic acids research, vol. 46, no. 17, pp. 8908-8916.


Edvardson, S, Nicolae, CM, Agrawal, PB, Mignot, C, Payne, K, Prasad, AN, Prasad, C, Sadler, L, Nava, C, Mullen, TE, Begtrup, A, Baskin, B, Powis, Z, Shaag, A, Keren, B, Moldovan, GL & Elpeleg, O 2017, 'Heterozygous De Novo UBTF Gain-of-Function Variant Is Associated with Neurodegeneration in Childhood', American Journal of Human Genetics, vol. 101, no. 2, pp. 267-273.


Nicolae, CM & Moldovan, GL 2016, 'ERKing Trypanosoma: PCNA phosphorylation as novel target', Cell Cycle, vol. 15, no. 23, pp. 3167-3168.
Shahrour, MA, Nicolae, CM, Edvardson, S, Ashhab, M, Galvan, AM, Constantin, D, Abu-Libdeh, B, Moldovan, GL & Elpeleg, O 2017, 'Erratum to: PARP10 deficiency manifests by severe developmental delay and DNA repair defect (Neurogenetics, (2016), 17, (227-232), 10.1007/s10048-016-0493-1)', Neurogenetics, vol. 18, no. 1.
Uckelmann, H, Blaszkiewicz, S, Nicolae, C, Haas, S, Schnell, A, Wurzer, S, Wagener, R, Aszodi, A & Essers, MAG 2016, 'Extracellular matrix protein Matrilin-4 regulates stressinduced HSC proliferation via CXCR4', Journal of Experimental Medicine, vol. 213, no. 10, pp. 1961-1971.
Choe, KN, Nicolae, CM, Constantin, D, Imamura Kawasawa, Y, Delgado-Diaz, MR, De, S, Freire, R, Smits, VA & Moldovan, GL 2016, 'HUWE1 interacts with PCNA to alleviate replication stress', EMBO Reports, vol. 17, no. 6, pp. 874-886.
Shahrour, MA, Nicolae, CM, Edvardson, S, Ashhab, M, Galvan, AM, Constantin, D, Abu-Libdeh, B, Moldovan, GL & Elpeleg, O 2016, 'PARP10 deficiency manifests by severe developmental delay and DNA repair defect', Neurogenetics, vol. 17, no. 4, pp. 227-232.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)