Researcher Profile

Researcher Profile

Claudia Nicolae, PhD

Claudia Nicolae, PhD

Assistant Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Next-Generation Therapies
cmn14@psu.edu

Research Interests

  • Matrilin Proteins
  • DNA Damage
  • Neoplasms
  • DNA Repair
  • Proliferating Cell Nuclear Antigen
  • Cell Proliferation
  • DNA Replication
  • Extracellular Matrix Proteins
  • Mutation
  • Genomic Instability
  • DNA
  • Collagen

Recent Publications

2020

Li, P, Fleischhauer, L, Nicolae, C, Prein, C, Farkas, Z, Saller, MM, Prall, WC, Wagener, R, Heilig, J, Niehoff, A, Clausen-Schaumann, H, Alberton, P & Aszodi, A 2020, 'Mice lacking the matrilin family of extracellular matrix proteins develop mild skeletal abnormalities and are susceptible to age-associated osteoarthritis', International journal of molecular sciences, vol. 21, no. 2, 666. https://doi.org/10.3390/ijms21020666
Thakar, T, Leung, W, Nicolae, CM, Clements, KE, Shen, B, Bielinsky, AK & Moldovan, GL 2020, 'Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly', Nature communications, vol. 11, no. 1, 2147. https://doi.org/10.1038/s41467-020-16096-w

2019

Naldiga, S, Ji, S, Thomforde, J, Nicolae, CM, Lee, M, Zhang, Z, Moldovan, GL, Tretyakova, NY & Basu, AK 2019, 'Error-prone replication of a 5-formylcytosine-mediated DNA-peptide cross-link in human cells', Journal of Biological Chemistry, vol. 294, no. 27, pp. 10619-10627. https://doi.org/10.1074/jbc.RA119.008879
Edvardson, S, Nicolae, CM, Noh, GJ, Burton, JE, Punzi, G, Shaag, A, Bischetsrieder, J, De Grassi, A, Pierri, CL, Elpeleg, O & Moldovan, GL 2019, 'Heterozygous RNF13 Gain-of-Function Variants Are Associated with Congenital Microcephaly, Epileptic Encephalopathy, Blindness, and Failure to Thrive', American Journal of Human Genetics, vol. 104, no. 1, pp. 179-185. https://doi.org/10.1016/j.ajhg.2018.11.018
Nicolae, CM, O’Connor, MJ, Schleicher, EM, Song, C, Gowda, R, Robertson, G, Dovat, S & Moldovan, GL 2019, 'PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells', Oncogene, vol. 38, no. 27, pp. 5530-5540. https://doi.org/10.1038/s41388-019-0810-x
Ranoa, DRE, Widau, RC, Mallon, S, Parekh, AD, Nicolae, CM, Huang, X, Bolt, MJ, Arina, A, Parry, R, Kron, SJ, Moldovan, GL, Khodarev, NN & Weichselbaum, RR 2019, 'STING promotes homeostasis via regulation of cell proliferation and chromosomal stability', Cancer Research, vol. 79, no. 7, pp. 1465-1479. https://doi.org/10.1158/0008-5472.CAN-18-1972

2018

Clements, KE, Thakar, T, Nicolae, CM, Liang, X, Wang, HG & Moldovan, GL 2018, 'Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells', Nucleic acids research, vol. 46, no. 17, pp. 8898-8907. https://doi.org/10.1093/nar/gky657
Nicolae, CM, O'connor, MJ, Constantin, D & Moldovan, GL 2018, 'NFκB regulates p21 expression and controls DNA damage-induced leukemic differentiation', Oncogene, vol. 37, no. 27, pp. 3647-3656. https://doi.org/10.1038/s41388-018-0219-y
Schleicher, EM, Galvan, AM, Imamura-Kawasawa, Y, Moldovan, GL & Nicolae, CM 2018, 'PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress', Nucleic acids research, vol. 46, no. 17, pp. 8908-8916. https://doi.org/10.1093/nar/gky658

2017

Edvardson, S, Nicolae, CM, Agrawal, PB, Mignot, C, Payne, K, Prasad, AN, Prasad, C, Sadler, L, Nava, C, Mullen, TE, Begtrup, A, Baskin, B, Powis, Z, Shaag, A, Keren, B, Moldovan, GL & Elpeleg, O 2017, 'Heterozygous De Novo UBTF Gain-of-Function Variant Is Associated with Neurodegeneration in Childhood', American Journal of Human Genetics, vol. 101, no. 2, pp. 267-273. https://doi.org/10.1016/j.ajhg.2017.07.002

2016

Nicolae, CM & Moldovan, GL 2016, 'ERKing Trypanosoma: PCNA phosphorylation as novel target', Cell Cycle, vol. 15, no. 23, pp. 3167-3168. https://doi.org/10.1080/15384101.2016.1232081
Shahrour, MA, Nicolae, CM, Edvardson, S, Ashhab, M, Galvan, AM, Constantin, D, Abu-Libdeh, B, Moldovan, GL & Elpeleg, O 2017, 'Erratum to: PARP10 deficiency manifests by severe developmental delay and DNA repair defect (Neurogenetics, (2016), 17, (227-232), 10.1007/s10048-016-0493-1)', Neurogenetics, vol. 18, no. 1. https://doi.org/10.1007/s10048-016-0503-3
Uckelmann, H, Blaszkiewicz, S, Nicolae, C, Haas, S, Schnell, A, Wurzer, S, Wagener, R, Aszodi, A & Essers, MAG 2016, 'Extracellular matrix protein Matrilin-4 regulates stressinduced HSC proliferation via CXCR4', Journal of Experimental Medicine, vol. 213, no. 10, pp. 1961-1971. https://doi.org/10.1084/jem.20151713
Choe, KN, Nicolae, CM, Constantin, D, Imamura Kawasawa, Y, Delgado-Diaz, MR, De, S, Freire, R, Smits, VA & Moldovan, GL 2016, 'HUWE1 interacts with PCNA to alleviate replication stress', EMBO Reports, vol. 17, no. 6, pp. 874-886. https://doi.org/10.15252/embr.201541685
Shahrour, MA, Nicolae, CM, Edvardson, S, Ashhab, M, Galvan, AM, Constantin, D, Abu-Libdeh, B, Moldovan, GL & Elpeleg, O 2016, 'PARP10 deficiency manifests by severe developmental delay and DNA repair defect', Neurogenetics, vol. 17, no. 4, pp. 227-232. https://doi.org/10.1007/s10048-016-0493-1

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)