Researcher Profile

Researcher Profile

Walter Koltun, MD

Walter Koltun, MD

Peter and Marshia Carlino Chair in Inflammatory Bowel Disease, Department of Surgery
Chief, Division of Colon and Rectal Surgery
Disease Teams:
Gastrointestinal Cancer

Research Interests

  • Crohn Disease
  • Inflammatory Bowel Diseases
  • Ulcerative Colitis
  • Therapeutics
  • Genes
  • Restorative Proctocolectomy
  • Single Nucleotide Polymorphism
  • Diverticulitis
  • Neoplasms
  • Inflammation
  • Colon
  • Colitis

Recent Publications


Gorrepati, V, Soriano, C, Johri, A, Dalessio, S, Stuart, A, Koltun, W, Tinsley, A, Clarke, K, Williams, E & Coates, M 2020, 'Abdominal Pain and Anxious or Depressed State Are Independently Associated With Weight Loss in Inflammatory Bowel Disease.', Crohn's & Colitis 360, vol. 2, no. 2. <>
Coates, MD, Johri, A, Gorrepati, VS, Maheshwari, P, Dalessio, S, Walter, V, Stuart, A, Koltun, W, Bernasko, N, Tinsley, A, Williams, ED & Clarke, K 2020, 'Abdominal pain in quiescent inflammatory bowel disease', International Journal of Colorectal Disease.
Kline, BP, Weaver, T, Brinton, DL, Deiling, S, Yochum, GS, Berg, AS & Koltun, WA 2020, 'Clinical and Genetic Factors Associated With Complications After Crohn's Ileocolectomy', Diseases of the colon and rectum, vol. 63, no. 3, pp. 357-364.
Pathak, T, Gueguinou, M, Walter, V, Delierneux, C, Johnson, MT, Zhang, X, Xin, P, Yoast, RE, Emrich, SM, Yochum, GS, Sekler, I, Koltun, WA, Gill, DL, Hempel, N & Trebak, M 2020, 'Dichotomous role of the human mitochondrial na+ /ca2+ /li+ exchanger nclx in colorectal cancer growth and metastasis', eLife, vol. 9, e59686, pp. 1-41.
Coates, MD, Soriano, C, Dalessio, S, Stuart, A, Walter, V, Koltun, W, Bernasko, N, Tinsley, A, Clarke, K & Williams, ED 2020, 'Gastrointestinal hypoalgesia in inflammatory bowel disease', Annals of Gastroenterology, vol. 33, no. 1, pp. 45-52.
Rawat, M, Nighot, M, Al-Sadi, R, Gupta, Y, Viszwapriya, D, Yochum, G, Koltun, W & Ma, TY 2020, 'IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA', Gastroenterology, vol. 159, no. 4, pp. 1375-1389.
Aguirre, JE, Beswick, EJ, Grim, C, Uribe, G, Tafoya, M, Palma, GC, Samedi, V, McKee, R, Villeger, R, Fofanov, Y, Cong, Y, Yochum, G, Koltun, W, Powell, D & Pinchuk, IV 2020, 'Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90+ (myo-)fibroblasts in Crohn’s disease and regulate Th1/Th17 cell responses', International immunology, vol. 32, no. 1, pp. 57-68.
Kulaylat, AN, Kulaylat, AS, Schaefer, EW, Mirkin, K, Tinsley, A, Williams, E, Koltun, WA, Hollenbeak, CS & Messaris, E 2020, 'The Impact of Preoperative Anti-TNFα Therapy on Postoperative Outcomes Following Ileocolectomy in Crohn’s Disease', Journal of Gastrointestinal Surgery.
Eshelman, MA, Harris, L, Deiling, S, Koltun, WA, Jeganathan, NA & Yochum, GS 2020, 'Transcriptomic analysis of ileal tissue from crohn’s disease patients identifies extracellular matrix genes that distinguish individuals by age at diagnosis', Physiological genomics, vol. 52, no. 10, pp. 478-484.


Gonzalez-Lopez, E, Kawasawa-Imamura, Y, Zhang, L, Huang, X, Koltun, WA, Coates, MD & Vrana, KE 2019, 'A single nucleotide polymorphism in dopamine beta hydroxylase (rs6271(C>T)) is over-represented in inflammatory bowel disease patients and reduces circulating enzyme', PloS one, vol. 14, no. 2, e0210175.
Denson, LA, Curran, M, McGovern, DPB, Koltun, WA, Duerr, RH, Kim, SC, Sartor, RB, Sylvester, FA, Abraham, C, de Zoeten, EF, Siegel, CA, Burns, RM, Dobes, AM, Shtraizent, N, Honig, G, Heller, CA, Hurtado-Lorenzo, A & Cho, JH 2019, 'Challenges in IBD Research: Precision Medicine', Inflammatory bowel diseases, vol. 25, pp. S31-S39.
Eshelman, MA, Jeganathan, NA, Schieffer, KM, Kline, BP, Mendenhall, M, Deiling, S, Harris, L, Koltun, WA & Yochum, GS 2019, 'Elevated colonic mucin expression correlates with extended time to surgery for ulcerative colitis patients', Journal of Gastrointestinal and Liver Diseases, vol. 28, no. 4, pp. 405-413.
Coates, MD, Kim, JS, Carkaci-Salli, N, Vrana, KE, Koltun, WA, Puhl, HL, Adhikary, SD, Janicki, PK & Ruiz-Velasco, V 2019, 'Impact of the NaV1.8 variant, A1073V, on post-sigmoidectomy pain and electrophysiological function in rat sympathetic neurons', Journal of neurophysiology, vol. 122, no. 6, pp. 2591-2600.
Gorrepati, VS, Stuart, A, Deiling, S, Koltun, W, Tinsley, A, Williams, ED & Coates, MD 2019, 'Response to the letter to the editor from dai et al, regarding "smoking and the risk of pouchitis in ulcerative colitis patients with ileal pouch anal anastomosis"', Inflammatory bowel diseases, vol. 25, no. 4, pp. E43.
Matthews, SM, Eshelman, MA, Berg, AS, Koltun, WA & Yochum, GS 2019, 'The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells', PloS one, vol. 14, no. 2, e0212850.
Eshelman, MA, Matthews, SM, Schleicher, EM, Fleeman, RM, Kawasawa, YI, Stumpo, DJ, Blackshear, PJ, Koltun, WA, Ishmael, FT & Yochum, GS 2019, 'Tristetraprolin targets Nos2 expression in the colonic epithelium', Scientific reports, vol. 9, no. 1, 14413.


Koltun, W 2018, '3D Modeling of the Anorectum in Fistulous Crohn's Disease: Long Overdue', Annals of surgery, vol. 267, no. 6, pp. e108.
Schieffer, KM, Kline, BP, Harris, LR, Deiling, S, Koltun, WA & Yochum, GS 2018, 'A differential host response to viral infection defines a subset of earlier-onset diverticulitis patients', Journal of Gastrointestinal and Liver Diseases, vol. 27, no. 3, pp. 249-255.
Gorrepati, VS, Stuart, A, Koltun, W, Messaris, E, Williams, E, Coates, M & Yadav, S 2018, 'Anxiety, depression, and inflammation after restorative proctocolectomy', International Journal of Colorectal Disease, vol. 33, no. 11, pp. 1601-1606.
Gonzalez-Lopez, E, Kawasawa, YI, Walter, V, Zhang, L, Koltun, WA, Huang, X, Vrana, KE & Coates, MD 2018, 'Homozygosity for the SCN10A polymorphism rs6795970 is associated with hypoalgesic inflammatory bowel disease phenotype', Frontiers in Medicine, vol. 5, no. NOV, 324.
Proksell, SS, Greer, JB, Theisen, BK, Davis, PL, Rosh, JR, Keljo, DJ, Goyal, A, Shah, SA, Brand, MH, Herfarth, HH, Cross, RK, Siegel, CA, Koltun, WA, Isaacs, KL & Regueiro, MD 2018, 'IBD LIVE Case Series: Case 9: Do Race and Extraintestinal Manifestations Affect Treatment of Severe Crohn's Colitis?', Inflammatory bowel diseases, vol. 24, no. 4, pp. 698-713.
Kline, BP, Schieffer, KM, Choi, CS, Connelly, T, Chen, J, Harris, L, Deiling, S, Yochum, GS & Koltun, WA 2019, 'Multifocal Versus Conventional Unifocal Diverticulitis: A Comparison of Clinical and Transcriptomic Characteristics', Digestive Diseases and Sciences, vol. 64, no. 11, pp. 3143-3151.
Schieffer, KM, Kline, BP, Yochum, G & Koltun, W 2018, 'Pathophysiology of diverticular disease', Expert Review of Gastroenterology and Hepatology, vol. 12, no. 7, pp. 683-692.
Lightner, AL, McKenna, NP, Tse, CS, Hyman, N, Smith, R, Ovsepyan, G, Fleshner, P, Crowell, K, Koltun, W, Ferrante, M, D'Hoore, A, Lauwers, N, Verstockt, B, Spinelli, A, DiCandido, F, Raffals, LE, Mathis, KL & Loftus, EV 2018, 'Postoperative outcomes in Ustekinumab- treated patients undergoing abdominal operations for Crohn's disease', Journal of Crohn's and Colitis, vol. 12, no. 4, pp. 402-407.
Stokes, AL, Kulaylat, AN, Rocourt, DV, Hollenbeak, CS, Koltun, W & Falaiye, T 2018, 'Rates and trends for inpatient surgeries in pediatric Crohn's disease in the United States from 2003 to 2012', Journal of pediatric surgery, vol. 53, no. 7, pp. 1334-1338.
Gorrepati, VS, Stuart, A, Deiling, S, Koltun, W, Tinsley, A, Williams, ED & Coates, MD 2018, 'Smoking and the Risk of Pouchitis in Ulcerative Colitis Patients with Ileal Pouch-Anal Anastomosis', Inflammatory bowel diseases, vol. 24, no. 9, pp. 2027-2032.
Crowell, KT, Tinsley, A, Williams, ED, Coates, MD, Bobb, A, Koltun, WA & Messaris, E 2018, 'Vedolizumab as a rescue therapy for patients with medically refractory Crohn's disease', Colorectal Disease, vol. 20, no. 10, pp. 905-912.


Kulaylat, AS, Kulaylat, AN, Schaefer, EW, Tinsley, A, Williams, E, Koltun, W, Hollenbeak, CS & Messaris, E 2017, 'Association of preoperative anti-tumor necrosis factor therapy with adverse postoperative outcomes in patients undergoing abdominal surgery for ulcerative colitis', JAMA Surgery, vol. 152, no. 8, pp. e171538.
Koltun, WA 2017, 'Better together: improved care of the IBD patient using the multi-disciplinary IBD center', Expert Review of Gastroenterology and Hepatology, vol. 11, no. 6, pp. 491-493.
Crowell, KT, Julian, KG, Katzman, M, Berg, AS, Tinsley, A, Williams, ED, Koltun, WA & Messaris, E 2017, 'Compliance with Clostridium difficile treatment guidelines: Effect on patient outcomes', Epidemiology and Infection, vol. 145, no. 11, pp. 2185-2192.
Schieffer, KM, Poritz, LS, Yochum, GS & Koltun, WA 2017, 'Development of a total colectomy and ileorectal anastomosis rat model to evaluate colonic metaplasia', Journal of Surgical Research, vol. 218, pp. 217-225.
Wrafter, PF, Connelly, TM, Khan, JSA, Lucey, BC, Berg, A, Koltun, W & Joyce, WP 2017, 'Diverticular disease is associated with benign intra-abdominal cystic disease', Expert Review of Gastroenterology and Hepatology, vol. 11, no. 5, pp. 487-490.
Connelly, TM, Choi, CS, Berg, AS, Harris, L, Coble, J & Koltun, WA 2017, 'Diverticulitis and Crohn's disease have distinct but overlapping tumor necrosis superfamily 15 haplotypes', Journal of Surgical Research, vol. 214, pp. 262-269.
Click, BH, Greer, JB, Regueiro, MD, Hartman, DJ, Davis, PL, Siegel, CA, Herfarth, HH, Rosh, JR, Shah, SA, Koltun, WA, Binion, DG, Baidoo, L & Szigethy, E 2017, 'IBD LIVE Series - Case 7: The Brain-Gut Connection and the Importance of Integrated Care in IBD', Inflammatory bowel diseases, vol. 23, no. 5, pp. 681-694.
Iskandar, H, Greer, JB, Krasinskas, AM, Tinsley, AT, Koltun, WA, Siegel, CA, Levy, LC, Herfarth, HH, Farraye, FA, Binion, DG, Rosh, JR, Keljo, DJ, Isaacs, KL & Regueiro, MD 2017, 'IBD LIVE Series - Case 8: Treatment Options for Refractory Esophageal Crohn's Disease and Hidradenitis Suppurativa', Inflammatory bowel diseases, vol. 23, no. 10, pp. 1667-1677.
Coble, JL, Yue, F, Salameh, TJ, Harris, LR, Deiling, S, Ruggiero, FM, Eshelman, MA, Yochum, GS, Koltun, WA, Gerhard, GS & Broach, JR 2017, 'Identification of a rare LAMB4 variant associated with familial diverticulitis through exome sequencing', Human molecular genetics, vol. 26, no. 16, ddx204, pp. 3212-3220.
Lightner, AL, Pemberton, JH, Dozois, EJ, Larson, DW, Cima, RR, Mathis, KL, Pardi, DS, Andrew, RE, Koltun, WA, Sagar, P & Hahnloser, D 2017, 'In Brief', Current Problems in Surgery, vol. 54, no. 4, pp. 163-166.
Stokes, AL, Tice, S, Follett, S, Paskey, D, Abraham, L, Bealer, C, Keister, H, Koltun, W & Puleo, FJ 2017, 'Institution of a preoperative stoma education group class decreases rate of peristomal complications in new stoma patients', Journal of Wound, Ostomy and Continence Nursing, vol. 44, no. 4, pp. 363-367.
Schieffer, KM, Wright, JR, Harris, LR, Deiling, S, Yang, Z, Lamendellab, R, Yochum, GS & Koltun, WA 2017, 'NOD2 genetic variants predispose one of two familial adenomatous polyposis siblings to pouchitis through microbiome dysbiosis', Journal of Crohn's and Colitis, vol. 11, no. 11, pp. 1393-1397.
Schieffer, KM, Choi, CS, Emrich, S, Harris, L, Deiling, S, Karamchandani, DM, Salzberg, A, Kawasawa, YI, Yochum, GS & Koltun, WA 2017, 'RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 313, no. 3, pp. G277-G284.
Schieffer, KM, Bruffy, SM, Rauscher, R, Koltun, WA, Yochum, GS & Gallagher, CJ 2017, 'Reduced total serum bilirubin levels are associated with ulcerative colitis', PloS one, vol. 12, no. 6, e0179267.
Schieffer, KM, Sabey, K, Wright, JR, Toole, DR, Drucker, R, Tokarev, V, Harris, LR, Deiling, S, Eshelman, MA, Hegarty, JP, Yochum, GS, Koltun, WA, Lamendella, R & Stewart, DB 2017, 'The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients', Scientific reports, vol. 7, no. 1, 8467.
Lightner, AL, Pemberton, JH, Dozois, EJ, Larson, DW, Cima, RR, Mathis, KL, Pardi, DS, Andrew, RE, Koltun, W, Sagar, P & Hahnloser, D 2017, 'The surgical management of inflammatory bowel disease', Current Problems in Surgery, vol. 54, no. 4, pp. 172-250.

Clinical Trials Search

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