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Walter Koltun, MD

Walter Koltun, MD

Peter and Marshia Carlino Chair in Inflammatory Bowel Disease, Department of Surgery
Chief, Division of Colon and Rectal Surgery
Disease Teams:
Cancer Institute, Gastrointestinal Cancer Team
WAK5@psu.edu

Research Interests

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  • Crohn Disease
  • Inflammatory Bowel Diseases
  • Ulcerative Colitis
  • Therapeutics
  • Genes
  • Single Nucleotide Polymorphism
  • Diverticulitis
  • Restorative Proctocolectomy
  • Neoplasms
  • Colitis
  • Colon
  • Permeability
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Recent Publications

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2024

Ding, W, Marx, OM, Mankarious, MM, Koltun, WA & Yochum, GS 2024, 'Disease Severity Impairs Generation of Intestinal Organoid Cultures From Inflammatory Bowel Disease Patients', Journal of Surgical Research, vol. 293, pp. 187-195. https://doi.org/10.1016/j.jss.2023.08.027
Marx, OM, Mankarious, MM, Koltun, WA & Yochum, GS 2024, 'Identification of differentially expressed genes and splicing events in early-onset colorectal cancer', Frontiers in Oncology, vol. 14, 1365762. https://doi.org/10.3389/fonc.2024.1365762

2023

Ganapathy, AS, Saha, K, Wang, A, Arumugam, P, Dharmaprakash, V, Yochum, G, Koltun, W, Nighot, M, Perdew, G, Thompson, TA, Ma, T & Nighot, P 2023, 'Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways', Cell Reports, vol. 42, no. 7, 112705. https://doi.org/10.1016/j.celrep.2023.112705
Saha, K, Subramenium Ganapathy, A, Wang, A, Arumugam, P, Michael Morris, N, Harris, L, Yochum, G, Koltun, W, Perdew, GH, Nighot, M, Ma, T & Nighot, P 2023, 'Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation', Mucosal Immunology, vol. 16, no. 6, pp. 826-842. https://doi.org/10.1016/j.mucimm.2023.09.003
Saha, K, Subramenium Ganapathy, A, Wang, A, Michael Morris, N, Suchanec, E, Ding, W, Yochum, G, Koltun, W, Nighot, M, Ma, T & Nighot, P 2023, 'Autophagy Reduces the Degradation and Promotes Membrane Localization of Occludin to Enhance the Intestinal EpithelialTight Junction Barrier against Paracellular Macromolecule Flux', Journal of Crohn's and Colitis, vol. 17, no. 3, pp. 433-449. https://doi.org/10.1093/ecco-jcc/jjac148
Tom, CM, Mankarious, MM, Jeganathan, NA, Deutsch, M, Koltun, WA, Berg, AS & Scow, JS 2023, 'Characteristics and Outcomes of Right- Versus Left-Sided Early-Onset Colorectal Cancer', Diseases of the colon and rectum, vol. 66, no. 4, pp. 498-510. https://doi.org/10.1097/DCR.0000000000002273
Xiao, L, Warner, B, Mallard, CG, Chung, HK, Shetty, A, Brantner, CA, Rao, JN, Yochum, GS, Koltun, WA, To, KB, Turner, DJ, Gorospe, M & Wang, JY 2023, 'Control of Paneth cell function by HuR regulates gut mucosal growth by altering stem cell activity', Life Science Alliance, vol. 6, no. 11, e202302152. https://doi.org/10.26508/lsa.202302152
Mankarious, MM, Connelly, TM, Harris, L, Deiling, S, Yochum, GS & Koltun, WA 2023, 'Creating a Surgical Biobank: The Hershey Medical Center Experience', Diseases of the colon and rectum, vol. 66, no. 9, pp. 1174-1184. https://doi.org/10.1097/DCR.0000000000002944
Nighot, M, Liao, PL, Morris, N, McCarthy, D, Dharmaprakash, V, Ullah Khan, I, Dalessio, S, Saha, K, Ganapathy, AS, Wang, A, Ding, W, Yochum, G, Koltun, W, Nighot, P & Ma, T 2023, 'Long-Term Use of Proton Pump Inhibitors Disrupts Intestinal Tight Junction Barrier and Exaggerates Experimental Colitis', Journal of Crohn's and Colitis, vol. 17, no. 4, pp. 565-579. https://doi.org/10.1093/ecco-jcc/jjac168
Panganiban, RP, Tuan, A, Hart, M, Pelton, M, Mikhail, D, Akhtar, S, Bogale, K, Deiling, S, Zhou, S, Coates, MD, Yochum, GS & Koltun, W 2023, 'Pyoderma Gangrenosum Is Associated With Increased Risk of Inflammatory Pouch-Related Complications: A Retrospective Cohort Study', Crohn's and Colitis 360, vol. 5, no. 3, otad024. https://doi.org/10.1093/crocol/otad024
King, CM, Marx, OM, Ding, W, Koltun, WA & Yochum, GS 2023, 'TCF7L1 Regulates LGR5 Expression in Colorectal Cancer Cells', Genes, vol. 14, no. 2, 481. https://doi.org/10.3390/genes14020481
Portolese, AC, McMullen, BN, Baker, SK, Chen See, JR, Yochum, GS, Koltun, WA, Lamendella, R & Jeganathan, NA 2023, 'The Microbiome of Complicated Diverticulitis: An Imbalance of Sulfur-Metabolizing Bacteria', Diseases of the colon and rectum, vol. 66, no. 5, pp. 707-715. https://doi.org/10.1097/DCR.0000000000002647

2022

Olecki, EJ, Kronfli, AP, Stahl, KA, King, S, Razavi, NC & Koltun, WA 2022, 'LA ANASTOMÓSIS DE RESERVORIO ILEAL AL ANO SIN ESTOMA NO ESTÁ ASOCIADO CON UN AUMENTO EN LA TASA DE FUGA ANASTOMÓTICA O DISFUNCIÓN DE LA BOLSA A LARGO PLAZO EN PACIENTES CON COLITIS ULCERATIVA', Diseases of the colon and rectum, vol. 65, no. 11, pp. 1342-1350. https://doi.org/10.1097/DCR.0000000000002274
Bogale, K, Maheshwari, P, Kang, M, Gorrepati, VS, Dalessio, S, Walter, V, Stuart, A, Koltun, W, Bernasko, N, Tinsley, A, Williams, ED, Clarke, K & Coates, MD 2022, 'Symptoms associated with healthcare resource utilization in the setting of inflammatory bowel disease', Scientific reports, vol. 12, no. 1, 10577. https://doi.org/10.1038/s41598-022-14838-y
Zhao, X, Yang, W, Yu, T, Yu, Y, Cui, X, Zhou, Z, Yang, H, Yu, Y, Bilotta, AJ, Yao, S, Xu, J, Zhou, J, Yochum, GS, Koltun, WA, Portolese, A, Zeng, D, Xie, J, Pinchuk, IV, Zhang, H & Cong, Y 2023, 'Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts', Gastroenterology, vol. 164, no. 1, pp. 89-102. https://doi.org/10.1053/j.gastro.2022.09.006
Marx, OM, Mankarious, MM, Eshelman, MA, Ding, W, Koltun, WA & Yochum, GS 2022, 'Transcriptome Analyses Identify Deregulated MYC in Early Onset Colorectal Cancer', Biomolecules, vol. 12, no. 9, 1223. https://doi.org/10.3390/biom12091223

2021

Ganapathy, AS, Saha, K, Suchanec, E, Singh, V, Verma, A, Yochum, G, Koltun, W, Nighot, M, Ma, T & Nighot, P 2022, 'AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability', Autophagy, vol. 18, no. 9, pp. 2086-2103. https://doi.org/10.1080/15548627.2021.2016233
Schieffer, KM, Emrich, SM, Yochum, GS & Koltun, WA 2021, 'CD163L1+CXCL10+ Macrophages are Enriched Within Colonic Lamina Propria of Diverticulitis Patients', Journal of Surgical Research, vol. 267, pp. 527-535. https://doi.org/10.1016/j.jss.2021.06.016
Kline, BP, Yochum, GS, Brinton, DL, Schieffer, KM, Weaver, T, Harris, L, Deiling, S, Berg, AS & Koltun, WA 2021, 'COLQ and ARHGAP15 are associated with diverticular disease and are expressed in the colon', Journal of Surgical Research, vol. 267, pp. 397-403. https://doi.org/10.1016/j.jss.2021.05.043
Kline, BP, Weaver, T, Brinton, DL, Harris, L, Yochum, GS, Berg, AS & Koltun, WA 2021, 'Clinical and Genetic Factors Impact Time to Surgical Recurrence After Ileocolectomy for Crohn's Disease', Annals of surgery, vol. 274, no. 2, pp. 346-351. https://doi.org/10.1097/SLA.0000000000003660
Grim, C, Noble, R, Uribe, G, Khanipov, K, Johnson, P, Koltun, WA, Watts, T, Fofanov, Y, Yochum, GS, Powell, DW, Beswick, EJ & Pinchuk, IV 2021, 'Impairment of Tissue-Resident Mesenchymal Stem Cells in Chronic Ulcerative Colitis and Crohn's Disease', Journal of Crohn's and Colitis, vol. 15, no. 8, pp. 1362-1375. https://doi.org/10.1093/ecco-jcc/jjab001
Bogale, K, Vrana, K, Konsavage, WR, Walter, V, Stuart, A, Dalessio, S, Koltun, W, Bernasko, N, Tinsley, A, Williams, E, Clarke, K & Coates, MD 2021, 'Polysubstance use in inflammatory bowel disease', Journal of Digestive Diseases, vol. 22, no. 12, pp. 706-713. https://doi.org/10.1111/1751-2980.13064
Jeganathan, NNA & Koltun, WA 2021, 'Special Considerations of Anastomotic Leaks in Crohn's Disease', Clinics in Colon and Rectal Surgery, vol. 34, no. 6, pp. 412-416. https://doi.org/10.1055/s-0041-1735273
Jeganathan, NA, Davenport, ER, Yochum, GS & Koltun, WA 2021, 'The microbiome of diverticulitis', Current Opinion in Physiology, vol. 22, 100452. https://doi.org/10.1016/j.cophys.2021.06.006

2020

Gorrepati, VS, Soriano, C, Johri, A, Dalessio, S, Stuart, A, Koltun, W, Tinsley, A, Clarke, K, Williams, E & Coates, M 2020, 'Abdominal pain and anxious or depressed state are independently associated with weight loss in inflammatory bowel disease', Crohn's and Colitis 360, vol. 2, no. 2. https://doi.org/10.1093/crocol/otaa047
Coates, MD, Johri, A, Gorrepati, VS, Maheshwari, P, Dalessio, S, Walter, V, Stuart, A, Koltun, W, Bernasko, N, Tinsley, A, Williams, ED & Clarke, K 2021, 'Abdominal pain in quiescent inflammatory bowel disease', International Journal of Colorectal Disease, vol. 36, no. 1, pp. 93-102. https://doi.org/10.1007/s00384-020-03727-3
Kline, BP, Weaver, T, Brinton, DL, Deiling, S, Yochum, GS, Berg, AS & Koltun, WA 2020, 'Clinical and Genetic Factors Associated With Complications After Crohn's Ileocolectomy', Diseases of the colon and rectum, vol. 63, no. 3, pp. 357-364. https://doi.org/10.1097/DCR.0000000000001574
Pathak, T, Gueguinou, M, Walter, V, Delierneux, C, Johnson, MT, Zhang, X, Xin, P, Yoast, RE, Emrich, SM, Yochum, GS, Sekler, I, Koltun, WA, Gill, DL, Hempel, N & Trebak, M 2020, 'Dichotomous role of the human mitochondrial na+ /ca2+ /li+ exchanger nclx in colorectal cancer growth and metastasis', eLife, vol. 9, e59686, pp. 1-41. https://doi.org/10.7554/ELIFE.59686
Coates, MD, Soriano, C, Dalessio, S, Stuart, A, Walter, V, Koltun, W, Bernasko, N, Tinsley, A, Clarke, K & Williams, ED 2020, 'Gastrointestinal hypoalgesia in inflammatory bowel disease', Annals of Gastroenterology, vol. 33, no. 1, pp. 45-52. https://doi.org/10.20524/aog.2019.0442
Rawat, M, Nighot, M, Al-Sadi, R, Gupta, Y, Viszwapriya, D, Yochum, G, Koltun, W & Ma, TY 2020, 'IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA', Gastroenterology, vol. 159, no. 4, pp. 1375-1389. https://doi.org/10.1053/j.gastro.2020.06.038
Aguirre, JE, Beswick, EJ, Grim, C, Uribe, G, Tafoya, M, Palma, GC, Samedi, V, McKee, R, Villeger, R, Fofanov, Y, Cong, Y, Yochum, G, Koltun, W, Powell, D & Pinchuk, IV 2020, 'Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90+ (myo-)fibroblasts in Crohn’s disease and regulate Th1/Th17 cell responses', International immunology, vol. 32, no. 1, pp. 57-68. https://doi.org/10.1093/intimm/dxz060
Kulaylat, AN, Kulaylat, AS, Schaefer, EW, Mirkin, K, Tinsley, A, Williams, E, Koltun, WA, Hollenbeak, CS & Messaris, E 2021, 'The Impact of Preoperative Anti-TNFα Therapy on Postoperative Outcomes Following Ileocolectomy in Crohn’s Disease', Journal of Gastrointestinal Surgery, vol. 25, no. 2, pp. 467-474. https://doi.org/10.1007/s11605-019-04334-6
Eshelman, MA, Harris, L, Deiling, S, Koltun, WA, Jeganathan, NA & Yochum, GS 2020, 'Transcriptomic analysis of ileal tissue from crohn’s disease patients identifies extracellular matrix genes that distinguish individuals by age at diagnosis', Physiological genomics, vol. 52, no. 10, pp. 478-484. https://doi.org/10.1152/physiolgenomics.00062.2020
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