Researcher Profile

Researcher Profile

Walter Koltun, MD

Walter Koltun, MD

Peter and Marshia Carlino Chair in Inflammatory Bowel Disease, Department of Surgery
Chief, Division of Colon and Rectal Surgery
Disease Teams:
Gastrointestinal Cancer

Research Interests

  • Crohn Disease
  • Inflammatory Bowel Diseases
  • Ulcerative Colitis
  • Therapeutics
  • Genes
  • Single Nucleotide Polymorphism
  • Restorative Proctocolectomy
  • Diverticulitis
  • Neoplasms
  • Colon
  • Permeability
  • Inflammation

Recent Publications


Bogale, K, Maheshwari, P, Kang, M, Gorrepati, VS, Dalessio, S, Walter, V, Stuart, A, Koltun, W, Bernasko, N, Tinsley, A, Williams, E, Clarke, K & Coates, MD 2022, 'Symptoms associated with healthcare resource utilization in the setting of inflammatory bowel disease', Scientific reports, vol. 12, no. 1, 10577.


Ganapathy, AS, Saha, K, Suchanec, E, Singh, V, Verma, A, Yochum, G, Koltun, W, Nighot, M, Ma, T & Nighot, P 2021, 'AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability', Autophagy.
Schieffer, KM, Emrich, SM, Yochum, GS & Koltun, WA 2021, 'CD163L1+CXCL10+ Macrophages are Enriched Within Colonic Lamina Propria of Diverticulitis Patients', Journal of Surgical Research, vol. 267, pp. 527-535.
Kline, BP, Yochum, GS, Brinton, DL, Schieffer, KM, Weaver, T, Harris, L, Deiling, S, Berg, AS & Koltun, WA 2021, 'COLQ and ARHGAP15 are associated with diverticular disease and are expressed in the colon', Journal of Surgical Research, vol. 267, pp. 397-403.
Kline, BP, Weaver, T, Brinton, DL, Harris, L, Yochum, GS, Berg, AS & Koltun, WA 2021, 'Clinical and Genetic Factors Impact Time to Surgical Recurrence After Ileocolectomy for Crohn's Disease', Annals of surgery, vol. 274, no. 2, pp. 346-351.
Grim, C, Noble, R, Uribe, G, Khanipov, K, Johnson, P, Koltun, WA, Watts, T, Fofanov, Y, Yochum, GS, Powell, DW, Beswick, EJ & Pinchuk, IV 2021, 'Impairment of Tissue-Resident Mesenchymal Stem Cells in Chronic Ulcerative Colitis and Crohn's Disease', Journal of Crohn's and Colitis, vol. 15, no. 8, pp. 1362-1375.
Bogale, K, Vrana, K, Konsavage, WR, Walter, V, Stuart, A, Dalessio, S, Koltun, W, Bernasko, N, Tinsley, A, Williams, E, Clarke, K & Coates, MD 2021, 'Polysubstance use in inflammatory bowel disease', Journal of Digestive Diseases, vol. 22, no. 12, pp. 706-713.
Jeganathan, NNA & Koltun, WA 2021, 'Special Considerations of Anastomotic Leaks in Crohn's Disease', Clinics in Colon and Rectal Surgery, vol. 34, no. 6, pp. 412-416.
Jeganathan, NA, Davenport, ER, Yochum, GS & Koltun, WA 2021, 'The microbiome of diverticulitis', Current Opinion in Physiology, vol. 22, 100452.


Gorrepati, VS, Soriano, C, Johri, A, Dalessio, S, Stuart, A, Koltun, W, Tinsley, A, Clarke, K, Williams, E & Coates, M 2020, 'Abdominal pain and anxious or depressed state are independently associated with weight loss in inflammatory bowel disease', Crohn's and Colitis 360, vol. 2, no. 2.
Coates, MD, Johri, A, Gorrepati, VS, Maheshwari, P, Dalessio, S, Walter, V, Stuart, A, Koltun, W, Bernasko, N, Tinsley, A, Williams, ED & Clarke, K 2021, 'Abdominal pain in quiescent inflammatory bowel disease', International Journal of Colorectal Disease, vol. 36, no. 1, pp. 93-102.
Kline, BP, Weaver, T, Brinton, DL, Deiling, S, Yochum, GS, Berg, AS & Koltun, WA 2020, 'Clinical and Genetic Factors Associated With Complications After Crohn's Ileocolectomy', Diseases of the colon and rectum, vol. 63, no. 3, pp. 357-364.
Pathak, T, Gueguinou, M, Walter, V, Delierneux, C, Johnson, MT, Zhang, X, Xin, P, Yoast, RE, Emrich, SM, Yochum, GS, Sekler, I, Koltun, WA, Gill, DL, Hempel, N & Trebak, M 2020, 'Dichotomous role of the human mitochondrial na+ /ca2+ /li+ exchanger nclx in colorectal cancer growth and metastasis', eLife, vol. 9, e59686, pp. 1-41.
Coates, MD, Soriano, C, Dalessio, S, Stuart, A, Walter, V, Koltun, W, Bernasko, N, Tinsley, A, Clarke, K & Williams, ED 2020, 'Gastrointestinal hypoalgesia in inflammatory bowel disease', Annals of Gastroenterology, vol. 33, no. 1, pp. 45-52.
Rawat, M, Nighot, M, Al-Sadi, R, Gupta, Y, Viszwapriya, D, Yochum, G, Koltun, W & Ma, TY 2020, 'IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA', Gastroenterology, vol. 159, no. 4, pp. 1375-1389.
Aguirre, JE, Beswick, EJ, Grim, C, Uribe, G, Tafoya, M, Palma, GC, Samedi, V, McKee, R, Villeger, R, Fofanov, Y, Cong, Y, Yochum, G, Koltun, W, Powell, D & Pinchuk, IV 2020, 'Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90+ (myo-)fibroblasts in Crohn’s disease and regulate Th1/Th17 cell responses', International immunology, vol. 32, no. 1, pp. 57-68.
Kulaylat, AN, Kulaylat, AS, Schaefer, EW, Mirkin, K, Tinsley, A, Williams, E, Koltun, WA, Hollenbeak, CS & Messaris, E 2021, 'The Impact of Preoperative Anti-TNFα Therapy on Postoperative Outcomes Following Ileocolectomy in Crohn’s Disease', Journal of Gastrointestinal Surgery, vol. 25, no. 2, pp. 467-474.
Eshelman, MA, Harris, L, Deiling, S, Koltun, WA, Jeganathan, NA & Yochum, GS 2020, 'Transcriptomic analysis of ileal tissue from crohn’s disease patients identifies extracellular matrix genes that distinguish individuals by age at diagnosis', Physiological genomics, vol. 52, no. 10, pp. 478-484.


Gonzalez-Lopez, E, Kawasawa-Imamura, Y, Zhang, L, Huang, X, Koltun, WA, Coates, MD & Vrana, KE 2019, 'A single nucleotide polymorphism in dopamine beta hydroxylase (rs6271(C>T)) is over-represented in inflammatory bowel disease patients and reduces circulating enzyme', PloS one, vol. 14, no. 2, e0210175.
Denson, LA, Curran, M, McGovern, DPB, Koltun, WA, Duerr, RH, Kim, SC, Sartor, RB, Sylvester, FA, Abraham, C, de Zoeten, EF, Siegel, CA, Burns, RM, Dobes, AM, Shtraizent, N, Honig, G, Heller, CA, Hurtado-Lorenzo, A & Cho, JH 2019, 'Challenges in IBD Research: Precision Medicine', Inflammatory bowel diseases, vol. 25, pp. S31-S39.
Eshelman, MA, Jeganathan, NA, Schieffer, KM, Kline, BP, Mendenhall, M, Deiling, S, Harris, L, Koltun, WA & Yochum, GS 2019, 'Elevated colonic mucin expression correlates with extended time to surgery for ulcerative colitis patients', Journal of Gastrointestinal and Liver Diseases, vol. 28, no. 4, pp. 405-413.
Coates, MD, Kim, JS, Carkaci-Salli, N, Vrana, KE, Koltun, WA, Puhl, HL, Adhikary, SD, Janicki, PK & Ruiz-Velasco, V 2019, 'Impact of the NaV1.8 variant, A1073V, on post-sigmoidectomy pain and electrophysiological function in rat sympathetic neurons', Journal of neurophysiology, vol. 122, no. 6, pp. 2591-2600.
Gorrepati, VS, Stuart, A, Deiling, S, Koltun, W, Tinsley, A, Williams, ED & Coates, MD 2019, 'Response to the letter to the editor from dai et al, regarding "smoking and the risk of pouchitis in ulcerative colitis patients with ileal pouch anal anastomosis"', Inflammatory bowel diseases, vol. 25, no. 4, pp. E43.
Matthews, SM, Eshelman, MA, Berg, AS, Koltun, WA & Yochum, GS 2019, 'The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells', PloS one, vol. 14, no. 2, e0212850.
Eshelman, MA, Matthews, SM, Schleicher, EM, Fleeman, RM, Kawasawa, YI, Stumpo, DJ, Blackshear, PJ, Koltun, WA, Ishmael, FT & Yochum, GS 2019, 'Tristetraprolin targets Nos2 expression in the colonic epithelium', Scientific reports, vol. 9, no. 1, 14413.


Koltun, W 2018, '3D Modeling of the Anorectum in Fistulous Crohn's Disease: Long Overdue', Annals of surgery, vol. 267, no. 6, pp. e108.
Schieffer, KM, Kline, BP, Harris, LR, Deiling, S, Koltun, WA & Yochum, GS 2018, 'A differential host response to viral infection defines a subset of earlier-onset diverticulitis patients', Journal of Gastrointestinal and Liver Diseases, vol. 27, no. 3, pp. 249-255.
Gorrepati, VS, Stuart, A, Koltun, W, Messaris, E, Williams, E, Coates, M & Yadav, S 2018, 'Anxiety, depression, and inflammation after restorative proctocolectomy', International Journal of Colorectal Disease, vol. 33, no. 11, pp. 1601-1606.
Gonzalez-Lopez, E, Kawasawa, YI, Walter, V, Zhang, L, Koltun, WA, Huang, X, Vrana, KE & Coates, MD 2018, 'Homozygosity for the SCN10A polymorphism rs6795970 is associated with hypoalgesic inflammatory bowel disease phenotype', Frontiers in Medicine, vol. 5, no. NOV, 324.
Proksell, SS, Greer, JB, Theisen, BK, Davis, PL, Rosh, JR, Keljo, DJ, Goyal, A, Shah, SA, Brand, MH, Herfarth, HH, Cross, RK, Siegel, CA, Koltun, WA, Isaacs, KL & Regueiro, MD 2018, 'IBD LIVE Case Series: Case 9: Do Race and Extraintestinal Manifestations Affect Treatment of Severe Crohn's Colitis?', Inflammatory bowel diseases, vol. 24, no. 4, pp. 698-713.
Kline, BP, Schieffer, KM, Choi, CS, Connelly, T, Chen, J, Harris, L, Deiling, S, Yochum, GS & Koltun, WA 2019, 'Multifocal Versus Conventional Unifocal Diverticulitis: A Comparison of Clinical and Transcriptomic Characteristics', Digestive Diseases and Sciences, vol. 64, no. 11, pp. 3143-3151.
Schieffer, KM, Kline, BP, Yochum, G & Koltun, W 2018, 'Pathophysiology of diverticular disease', Expert Review of Gastroenterology and Hepatology, vol. 12, no. 7, pp. 683-692.
Lightner, AL, McKenna, NP, Tse, CS, Hyman, N, Smith, R, Ovsepyan, G, Fleshner, P, Crowell, K, Koltun, W, Ferrante, M, D'Hoore, A, Lauwers, N, Verstockt, B, Spinelli, A, DiCandido, F, Raffals, LE, Mathis, KL & Loftus, EV 2018, 'Postoperative outcomes in Ustekinumab- treated patients undergoing abdominal operations for Crohn's disease', Journal of Crohn's and Colitis, vol. 12, no. 4, pp. 402-407.
Stokes, AL, Kulaylat, AN, Rocourt, DV, Hollenbeak, CS, Koltun, W & Falaiye, T 2018, 'Rates and trends for inpatient surgeries in pediatric Crohn's disease in the United States from 2003 to 2012', Journal of pediatric surgery, vol. 53, no. 7, pp. 1334-1338.
Gorrepati, VS, Stuart, A, Deiling, S, Koltun, W, Tinsley, A, Williams, ED & Coates, MD 2018, 'Smoking and the Risk of Pouchitis in Ulcerative Colitis Patients with Ileal Pouch-Anal Anastomosis', Inflammatory bowel diseases, vol. 24, no. 9, pp. 2027-2032.
Crowell, KT, Tinsley, A, Williams, ED, Coates, MD, Bobb, A, Koltun, WA & Messaris, E 2018, 'Vedolizumab as a rescue therapy for patients with medically refractory Crohn's disease', Colorectal Disease, vol. 20, no. 10, pp. 905-912.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)