Researcher Profile

Researcher Profile

Walter Koltun, MD

Walter Koltun, MD

Peter and Marshia Carlino Chair in Inflammatory Bowel Disease, Department of Surgery
Chief, Division of Colon and Rectal Surgery
Disease Teams:
Gastrointestinal Cancer
wak5@psu.edu

Research Interests

  • Crohn Disease
  • Inflammatory Bowel Diseases
  • Ulcerative Colitis
  • Therapeutics
  • Genes
  • Colonic Pouches
  • Single Nucleotide Polymorphism
  • Neoplasms
  • Diverticulitis
  • Colectomy
  • Colitis
  • Colon

Recent Publications

2019

Gonzalez-Lopez, E, Kawasawa-Imamura, Y, Zhang, L, Huang, X, Koltun, W, Coates, M & Vrana, K 2019, 'A single nucleotide polymorphism in dopamine beta hydroxylase (rs6271(C>T)) is over-represented in inflammatory bowel disease patients and reduces circulating enzyme', PloS one, vol. 14, no. 2, e0210175. https://doi.org/10.1371/journal.pone.0210175
Denson, LA, Curran, M, McGovern, DPB, Koltun, W, Duerr, RH, Kim, SC, Sartor, RB, Sylvester, FA, Abraham, C, de Zoeten, EF, Siegel, CA, Burns, RM, Dobes, AM, Shtraizent, N, Honig, G, Heller, CA, Hurtado-Lorenzo, A & Cho, JH 2019, 'Challenges in IBD Research: Precision Medicine', Inflammatory bowel diseases, vol. 25, no. 2, pp. S31-S39. https://doi.org/10.1093/ibd/izz078
Gorrepati, VS, Stuart, A, Deiling, S, Koltun, W, Tinsley, A, Williams, E & Coates, M 2019, 'Response to the letter to the editor from dai et al, regarding "smoking and the risk of pouchitis in ulcerative colitis patients with ileal pouch anal anastomosis"', Inflammatory bowel diseases, vol. 25, no. 4, pp. E43. https://doi.org/10.1093/ibd/izy261
Matthews, SM, Eshelman, MA, Berg, A, Koltun, W & Yochum, G 2019, 'The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells' PloS one, vol. 14, no. 2, e0212850. https://doi.org/10.1371/journal.pone.0212850

2018

Koltun, W 2018, '3D Modeling of the Anorectum in Fistulous Crohn's Disease: Long Overdue', Annals of Surgery, vol. 267, no. 6, pp. e108. https://doi.org/10.1097/SLA.0000000000002748
Schieffer, KM, Kline, BP, Harris, LR, Deiling, S, Koltun, W & Yochum, G 2018, 'A differential host response to viral infection defines a subset of earlier-onset diverticulitis patients' Journal of Gastrointestinal and Liver Diseases, vol. 27, no. 3, pp. 249-255. https://doi.org/10.15403/jgld.2014.1121.273.sch
Gorrepati, VS, Yadav, S, Stuart, A, Koltun, W, Messaris, E, Williams, E & Coates, M 2018, 'Anxiety, depression, and inflammation after restorative proctocolectomy', International Journal of Colorectal Disease, vol. 33, no. 11, pp. 1601-1606. https://doi.org/10.1007/s00384-018-3110-y
Gonzalez-Lopez, E, Imamura, Y, Walter, V, Zhang, L, Koltun, W, Huang, X, Vrana, K & Coates, M 2018, 'Homozygosity for the SCN10A polymorphism rs6795970 is associated with hypoalgesic inflammatory bowel disease phenotype', Frontiers in Medicine, vol. 5, no. NOV, 324. https://doi.org/10.3389/fmed.2018.00324
Proksell, SS, Greer, JB, Theisen, BK, Davis, PL, Rosh, JR, Keljo, DJ, Goyal, A, Shah, SA, Brand, MH, Herfarth, HH, Cross, RK, Siegel, CA, Koltun, W, Isaacs, KL & Regueiro, MD 2018, 'IBD LIVE Case Series: Case 9: Do Race and Extraintestinal Manifestations Affect Treatment of Severe Crohn's Colitis?', Inflammatory bowel diseases, vol. 24, no. 4, pp. 698-713. https://doi.org/10.1093/ibd/izx114
Kline, BP, Schieffer, KM, Choi, CS, Connelly, T, Chen, J, Harris, L, Deiling, S, Yochum, G & Koltun, W 2018, 'Multifocal Versus Conventional Unifocal Diverticulitis: A Comparison of Clinical and Transcriptomic Characteristics', Digestive Diseases and Sciences. https://doi.org/10.1007/s10620-018-5403-y
Schieffer, KM, Kline, BP, Yochum, G & Koltun, W 2018, 'Pathophysiology of diverticular disease', Expert Review of Gastroenterology and Hepatology, vol. 12, no. 7, pp. 683-692. https://doi.org/10.1080/17474124.2018.1481746
Lightner, AL, McKenna, NP, Tse, CS, Hyman, N, Smith, R, Ovsepyan, G, Fleshner, P, Crowell, K, Koltun, W, Ferrante, M, D'Hoore, A, Lauwers, N, Verstockt, B, Spinelli, A, DiCandido, F, Raffals, LE, Mathis, KL & Loftus, EV 2018, 'Postoperative outcomes in Ustekinumab- treated patients undergoing abdominal operations for Crohn's disease', Journal of Crohn's and Colitis, vol. 12, no. 4, pp. 402-407. https://doi.org/10.1093/ECCO-JCC/JJX163
Stokes, AL, Kulaylat, AN, Rocourt, D, Hollenbeak, CS, Koltun, W & Falaiye, T 2018, 'Rates and trends for inpatient surgeries in pediatric Crohn's disease in the United States from 2003 to 2012', Journal of Pediatric Surgery, vol. 53, no. 7, pp. 1334-1338. https://doi.org/10.1016/j.jpedsurg.2017.11.060
Gorrepati, VS, Stuart, A, Deiling, S, Koltun, W, Tinsley, A, Williams, E & Coates, M 2018, 'Smoking and the Risk of Pouchitis in Ulcerative Colitis Patients with Ileal Pouch-Anal Anastomosis', Inflammatory bowel diseases, vol. 24, no. 9, pp. 2027-2032. https://doi.org/10.1093/ibd/izy097
Crowell, KT, Tinsley, A, Williams, E, Coates, M, Bobb, A, Koltun, W & Messaris, E 2018, 'Vedolizumab as a rescue therapy for patients with medically refractory Crohn's disease', Colorectal Disease. https://doi.org/10.1111/codi.14225

2017

Kulaylat, AS, Kulaylat, AN, Schaefer, EW, Tinsley, A, Williams, E, Koltun, W, Hollenbeak, CS & Messaris, E 2017, 'Association of preoperative anti-tumor necrosis factor therapy with adverse postoperative outcomes in patients undergoing abdominal surgery for ulcerative colitis', JAMA Surgery, vol. 152, no. 8, pp. e171538. https://doi.org/10.1001/jamasurg.2017.1538
Koltun, W 2017, 'Better together: improved care of the IBD patient using the multi-disciplinary IBD center', Expert Review of Gastroenterology and Hepatology, vol. 11, no. 6, pp. 491-493. https://doi.org/10.1080/17474124.2017.1309289
Crowell, KT, Julian, K, Katzman, M, Berg, A, Tinsley, A, Williams, E, Koltun, W & Messaris, E 2017, 'Compliance with Clostridium difficile treatment guidelines: Effect on patient outcomes', Epidemiology and Infection, vol. 145, no. 11, pp. 2185-2192. https://doi.org/10.1017/S0950268817000644
Schieffer, KM, Poritz, L, Yochum, G & Koltun, W 2017, 'Development of a total colectomy and ileorectal anastomosis rat model to evaluate colonic metaplasia', Journal of Surgical Research, vol. 218, pp. 217-225. https://doi.org/10.1016/j.jss.2017.05.120
Wrafter, PF, Connelly, TM, Khan, JSA, Lucey, BC, Berg, A, Koltun, W & Joyce, WP 2017, 'Diverticular disease is associated with benign intra-abdominal cystic disease', Expert Review of Gastroenterology and Hepatology, vol. 11, no. 5, pp. 487-490. https://doi.org/10.1080/17474124.2017.1294061
Connelly, TM, Choi, CS, Berg, A, Harris, L, Coble, J & Koltun, W 2017, 'Diverticulitis and Crohn's disease have distinct but overlapping tumor necrosis superfamily 15 haplotypes', Journal of Surgical Research, vol. 214, pp. 262-269. https://doi.org/10.1016/j.jss.2017.02.030
Click, BH, Greer, JB, Regueiro, MD, Hartman, DJ, Davis, PL, Siegel, CA, Herfarth, HH, Rosh, JR, Shah, SA, Koltun, W, Binion, DG, Baidoo, L & Szigethy, E 2017, 'IBD LIVE Series - Case 7: The Brain-Gut Connection and the Importance of Integrated Care in IBD', Inflammatory Bowel Diseases, vol. 23, no. 5, pp. 681-694. https://doi.org/10.1097/MIB.0000000000001101
Iskandar, H, Greer, JB, Krasinskas, AM, Tinsley, A, Koltun, W, Siegel, CA, Levy, LC, Herfarth, HH, Farraye, FA, Binion, DG, Rosh, JR, Keljo, DJ, Isaacs, KL & Regueiro, MD 2017, 'IBD LIVE Series - Case 8: Treatment Options for Refractory Esophageal Crohn's Disease and Hidradenitis Suppurativa', Inflammatory bowel diseases, vol. 23, no. 10, pp. 1667-1677. https://doi.org/10.1097/MIB.0000000000001266
Coble, JL, Yue, F, Salameh, TJ, Harris, LR, Deiling, S, Ruggiero, FM, Eshelman, MA, Yochum, GS, Koltun, WA, Gerhard, GS & Broach, JR 2017, 'Identification of a rare LAMB4 variant associated with familial diverticulitis through exome sequencing', Human Molecular Genetics, vol. 26, no. 16, ddx204, pp. 3212-3220. https://doi.org/10.1093/hmg/ddx204
Lightner, AL, Pemberton, JH, Dozois, EJ, Larson, DW, Cima, RR, Mathis, KL, Pardi, DS, Andrew, RE, Koltun, W, Sagar, P & Hahnloser, D 2017, 'In Brief', Current Problems in Surgery, vol. 54, no. 4, pp. 163-166. https://doi.org/10.1067/j.cpsurg.2017.02.007
Stokes, AL, Tice, S, Follett, S, Paskey, D, Abraham, L, Bealer, C, Keister, H, Koltun, W & Puleo, F 2017, 'Institution of a preoperative stoma education group class decreases rate of peristomal complications in new stoma patients', Journal of Wound, Ostomy and Continence Nursing, vol. 44, no. 4, pp. 363-367. https://doi.org/10.1097/WON.0000000000000338
Schieffer, KM, Wright, JR, Harris, LR, Deiling, S, Yang, Z, Lamendellab, R, Yochum, G & Koltun, W 2017, 'NOD2 genetic variants predispose one of two familial adenomatous polyposis siblings to pouchitis through microbiome dysbiosis' Journal of Crohn's and Colitis, vol. 11, no. 11, pp. 1393-1397. https://doi.org/10.1093/ecco-jcc/jjx083
Schieffer, KM, Choi, CS, Emrich, S, Harris, L, Deiling, S, Karamchandani, D, Salzberg, A, Imamura, Y, Yochum, G & Koltun, W 2017, 'RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 313, no. 3, pp. G277-G284. https://doi.org/10.1152/ajpgi.00136.2017
Schieffer, KM, Bruffy, SM, Rauscher, R, Koltun, W, Yochum, G & Gallagher, CJ 2017, 'Reduced total serum bilirubin levels are associated with ulcerative colitis', PloS one, vol. 12, no. 6, e0179267. https://doi.org/10.1371/journal.pone.0179267
Schieffer, KM, Sabey, K, Wright, JR, Toole, DR, Drucker, R, Tokarev, V, Harris, LR, Deiling, S, Eshelman, MA, Hegarty, JP, Yochum, G, Koltun, W, Lamendella, R & Stewart, D 2017, 'The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients', Scientific reports, vol. 7, no. 1, 8467. https://doi.org/10.1038/s41598-017-06787-8
Lightner, AL, Pemberton, JH, Dozois, EJ, Larson, DW, Cima, RR, Mathis, KL, Pardi, DS, Andrew, RE, Koltun, W, Sagar, P & Hahnloser, D 2017, 'The surgical management of inflammatory bowel disease', Current Problems in Surgery, vol. 54, no. 4, pp. 172-250. https://doi.org/10.1067/j.cpsurg.2017.02.006

2016

Choi, CS, Berg, A, Sangster, W, Schieffer, KM, Harris, LR, Deiling, SM & Koltun, W 2016, 'Combined Medical and Surgical Approach Improves Healing of Septic Perianal Crohn's Disease', Journal of the American College of Surgeons, vol. 223, no. 3, pp. 506-514.e1. https://doi.org/10.1016/j.jamcollsurg.2016.05.017
Choi, CS, Koltun, W & Hollenbeak, CS 2016, 'Higher mortality in surgically managed diverticulitis is associated with Asian Ethnicity and right-sided disease', Diseases of the Colon and Rectum, vol. 59, no. 3, pp. 216-223. https://doi.org/10.1097/DCR.0000000000000526
Sangster, W, Berg, A, Choi, CS, Connelly, TM, Chesnut, CH, Koltun, W & Stewart, D 2016, 'Outcomes of early ileocolectomy after percutaneous drainage for perforated ileocolic Crohn's disease', American Journal of Surgery, vol. 212, no. 4, pp. 728-734. https://doi.org/10.1016/j.amjsurg.2016.01.044
Schieffer, KM, Williams, E, Yochum, G & Koltun, W 2016, 'Review article: the pathogenesis of pouchitis', Alimentary Pharmacology and Therapeutics, vol. 44, no. 8, pp. 817-835. https://doi.org/10.1111/apt.13780

2015

Koltun, W 2015, 'Diverticulosis and colon cancer: In reply to prasad and colleagues', Journal of the American College of Surgeons, vol. 220, no. 1. https://doi.org/10.1016/j.jamcollsurg.2014.10.006
Connelly, TM, Berg, A, Iii, LH, Brinton, D, Deiling, S & Koltun, W 2015, 'Genetic determinants associated with early age of diagnosis of IBD', Diseases of the colon and rectum, vol. 58, no. 3, pp. 321-327. https://doi.org/10.1097/DCR.0000000000000274
Sangster, W, Kulaylat, AN, Stewart, D, Schubart, JR, Koltun, W & Messaris, E 2015, 'Hernia incidence following single-site vs standard laparoscopic colorectal surgery', Colorectal Disease, vol. 17, no. 3, pp. 250-256. https://doi.org/10.1111/codi.12797
Le, PN, Greer, JB, Oikonomou, I, Schraut, WH, Siegel, CA, Cross, RK, Holubar, SD, Tinsley, A, Koltun, W, Binion, DG & Regueiro, MD 2015, 'IBD LIVE case series-case 2: Previous cancer in a patient with Crohn's disease: Is it appropriate to use biologics and immunosuppressants for IBD treatment?', Inflammatory Bowel Diseases, vol. 21, no. 6, pp. 1401-1406. https://doi.org/10.1097/MIB.0000000000000435
Connelly, TM & Koltun, W 2015, Molecular and genetic factors 2 in crohn's disease. in Crohn's Disease: Basic Principles. Springer International Publishing, pp. 15-33. https://doi.org/10.1007/978-3-319-14181-7_2
McAllister, BP, Williams, E, Yoo, LJ, Tinsley, A, Koltun, W, Ardell, CM, Follett, SB & Paskey, DM 2015, 'Refractory peristomal pyoderma gangrenosum successfully treated with intravenous immunoglobulin: A case report', American Journal of Gastroenterology, vol. 110, no. 12, pp. 1739-1740. https://doi.org/10.1038/ajg.2015.344
Connelly, TM, Berg, A, Harris, LR, Tappouni, R, Brinton, D, Deiling, S & Koltun, W 2015, 'Surgical diverticulitis is not associated with defects in the expression of wound healing genes' International Journal of Colorectal Disease, vol. 30, no. 9, pp. 1247-1254. https://doi.org/10.1007/s00384-015-2263-1
Wilson, MZ, Connelly, TM, Tinsley, A, Hollenbeak, CS, Koltun, W & Messaris, E 2015, 'Ulcerative colitis is associated with an increased risk of venous thromboembolism in the postoperative period: The results of a matched cohort analysis', Annals of Surgery, vol. 261, no. 6, pp. 1160-1166. https://doi.org/10.1097/SLA.0000000000000788

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)