Researcher Profile

Researcher Profile

Patrick Chi-Chung Ma, MD, MSc

Patrick Chi-Chung Ma, MD, MSc

Professor, Department of Medicine
Scientific Program:Next-Generation Therapies

Research Interests

  • Therapeutics
  • Neoplasms
  • Lung Neoplasms
  • Non-Small Cell Lung Carcinoma
  • Mutation
  • Small Cell Lung Carcinoma
  • Hepatocyte Growth Factor
  • ErbB Receptors
  • Neoplasm Metastasis
  • Protein-Tyrosine Kinases
  • Erlotinib Hydrochloride
  • Adenocarcinoma of Lung

Clinical Trials

APG-115 - A Phase Ib/II Study of APG-115 in Combination with Pembrolizumab in Patients with Unresectable or Metastatic Melanomas or Advanced Solid Tumors
Phase 1/2 Multicenter Study of the Safety, Pharmacokinetics, and Preliminary Efficacy of APL-101 in Subjects with Non-Small Cell Lung Cancer with c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
A Phase 3, Randomized, Placebo-Controlled Clinical Study to Evaluate the Safety and Efficacy of Stereotactic Body Radiotherapy (SBRT) with or without Pembrolizumab (MK-3475) in Participants with Medically Inoperable Stages I or IIA Non Small Cell Lung Cancer (NSCLC)(KEYNOTE-867) MK 3475-867

Recent Publications


Attia, CG, Fei, N, Almubarak, M, Ma, PC & Mattes, MD 2020, 'Patterns of disease progression to checkpoint inhibitor immunotherapy in patients with stage IV non-small cell lung cancer', Journal of Medical Imaging and Radiation Oncology, vol. 64, no. 6, pp. 866-872.


Ma, PC 2019, '(Not giving up) the marathon race of Met targeting therapy: Are we there yet?', Clinical Cancer Research, vol. 25, no. 8, pp. 2375-2378.
Jonna, S, Feldman, RA, Swensen, J, Gatalica, Z, Korn, WM, Borghaei, H, Ma, PC, Nieva, JJ, Spira, AI, Vanderwalde, AM, Wozniak, AJ, Kim, ES & Liu, SV 2019, 'Detection of NRG1 gene fusions in solid tumors', Clinical Cancer Research, vol. 25, no. 16, pp. 4966-4972.
Lim, ZF & Ma, PC 2019, 'Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy', Journal of Hematology and Oncology, vol. 12, no. 1, 134.
Chen, R, Xia, W, Wang, S, Xu, Y, Ma, Z, Xu, W, Zhang, E, Wang, J, Fang, T, Zhang, Q, Dong, G, Cho, WCS, Ma, PC, Brandi, G, Tavolari, S, Ujhazy, P, Metro, G, Popper, HH, Yin, R, Qiu, M & Xu, L 2019, 'Long Noncoding RNA SBF2-AS1 Is Critical for Tumorigenesis of Early-Stage Lung Adenocarcinoma', Molecular Therapy - Nucleic Acids, vol. 16, pp. 543-553.
Ahmad, Z, Stanazai, Q, Wright, S, Smolkin, M & Ma, PC 2019, 'Primary pleural epithelioid sarcoma of the proximal type: A diagnostic and therapeutic challenge', Translational Lung Cancer Research, vol. 8, no. 5, pp. 700-705.
Morgensztern, D, Rose, M, Waqar, SN, Morris, J, Ma, PC, Reid, T, Brzezniak, CE, Zeman, KG, Padmanabhan, A, Hirth, JA, I. Spira, A, Trepel, JB & Padda, SK 2019, 'RRx-001 followed by platinum plus etoposide in patients with previously treated small-cell lung cancer', British Journal of Cancer, vol. 121, no. 3, pp. 211-217.
Kibirova, A, Mattes, MD, Smolkin, M & Ma, PC 2019, 'The Journey of an EGFR-Mutant Lung Adenocarcinoma through Erlotinib, Osimertinib and ABCP Immunotherapy Regimens: Sensitivity and Resistance', Case Reports in Oncology, vol. 12, no. 3, pp. 765-776.


Drilon, A, Laetsch, TW, Kummar, S, Dubois, SG, Lassen, UN, Demetri, GD, Nathenson, M, Doebele, RC, Farago, AF, Pappo, AS, Turpin, B, Dowlati, A, Brose, MS, Mascarenhas, L, Federman, N, Berlin, J, El-Deiry, WS, Baik, C, Deeken, J, Boni, V, Nagasubramanian, R, Taylor, M, Rudzinski, ER, Meric-Bernstam, F, Sohal, DPS, Ma, PC, Raez, LE, Hechtman, JF, Benayed, R, Ladanyi, M, Tuch, BB, Ebata, K, Cruickshank, S, Ku, NC, Cox, MC, Hawkins, DS, Hong, DS & Hyman, DM 2018, 'Efficacy of larotrectinib in TRK fusion-positive cancers in adults and children', New England Journal of Medicine, vol. 378, no. 8, pp. 731-739.
Oronsky, B, Ma, P, Reid, TR, Cabrales, P, Lybeck, M, Oronsky, A, Oronsky, N & Carter, CA 2018, 'Navigating the “No Man's Land” of TKI-Failed EGFR-Mutated Non–Small Cell Lung Cancer (NSCLC): A Review', Neoplasia (United States), vol. 20, no. 1, pp. 92-98.
Wu, X, Zhu, L & Ma, PC 2018, 'Next-Generation Novel Noninvasive Cancer Molecular Diagnostics Platforms Beyond Tissues', American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, no. 38, pp. 964-977.


Wu, X, Ma, W, Zhou, Q, Yan, H, Lim, ZF, Huang, M, Deng, C, Yu, X, Su, H, Komo, S, Yang, H, Zhang, X, Wen, S, Zhang, Z & Ma, PC 2017, 'AXL–GAS6 expression can predict for adverse prognosis in non-small cell lung cancer with brain metastases', Journal of Cancer Research and Clinical Oncology, vol. 143, no. 10, pp. 1947-1957.
Chaib, I, Karachaliou, N, Pilotto, S, Codony Servat, J, Cai, X, Li, X, Drozdowskyj, A, Servat, CC, Yang, J, Hu, C, Cardona, AF, Vivanco, GL, Vergnenegre, A, Sanchez, JM, Provencio, M, de Marinis, F, Passaro, A, Cao, P, Reguart, N, Campelo, CG, Teixido, C, Sperduti, I, Rodriguez, S, Lazzari, C, Verlicchi, A, de Aguirre, I, Queralt, C, Wei, J, Estrada, R, de la Bellacasa, RP, Ramirez, JL, Jacobsen, K, Ditzel, HJ, Santarpia, M, Viteri, S, Molina, MA, Zhou, C, Cao, P, Ma, PC, Bivona, TG & Rosell, R 2017, 'Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC', Journal of the National Cancer Institute, vol. 109, no. 9.
Boothe, JT, Budd, GT, Smolkin, MB & Ma, PC 2017, 'Durable near-complete response to Anti-PD-1 checkpoint immunotherapy in a refractory malignant solitary fibrous tumor of the pleura', Case Reports in Oncology, vol. 10, no. 3, pp. 998-1005.
Oronsky, B, Ma, PC, Morgensztern, D & Carter, CA 2017, 'Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas', Neoplasia (United States), vol. 19, no. 12, pp. 991-1002.
Ma, PC 2017, 'Special issue: "MET as actionable target in cancer therapy"', Annals of Translational Medicine, vol. 5, no. 1, 1.
Pilotto, S, Carbognin, L, Karachaliou, N, Ma, PC, Rosell, R, Tortora, G & Bria, E 2017, 'Tracking MET de-addiction in lung cancer: A road towards the oncogenic target', Cancer Treatment Reviews, vol. 60, pp. 1-11.
Guo, T, Zhao, S, Wang, P, Xue, X, Zhang, Y, Yang, M, Li, N, Li, Z, Xu, L, Jiang, L, Zhao, L, Ma, PC, Rosell, R, Li, J & Gu, C 2017, 'YB-1 regulates tumor growth by promoting MACC1/c-Met pathway in human lung adenocarcinoma', Oncotarget, vol. 8, no. 29, pp. 48110-48125.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)