Researcher Profile

Researcher Profile

Patrick Chi-Chung Ma, MD, MSc

Patrick Chi-Chung Ma, MD, MSc

Professor, Department of Medicine
Scientific Program:Experimental Therapeutics
pcm5221@psu.edu

Research Interests

  • Therapeutics
  • Neoplasms
  • Lung Neoplasms
  • Non-Small Cell Lung Carcinoma
  • Mutation
  • Small Cell Lung Carcinoma
  • Hepatocyte Growth Factor
  • Epidermal Growth Factor Receptor
  • Neoplasm Metastasis
  • Receptor Protein-Tyrosine Kinases
  • Protein-Tyrosine Kinases
  • Proteins

Recent Publications

2019

Ma, PC-C 2019, '(Not giving up) the marathon race of Met targeting therapy: Are we there yet?', Clinical Cancer Research, vol. 25, no. 8, pp. 2375-2378. https://doi.org/10.1158/1078-0432.CCR-18-3739
Jonna, S, Feldman, RA, Swensen, J, Gatalica, Z, Korn, WM, Borghaei, H, Ma, PC-C, Nieva, JJ, Spira, AI, Vanderwalde, AM, Wozniak, AJ, Kim, ES & Liu, SV 2019, 'Detection of NRG1 gene fusions in solid tumors', Clinical Cancer Research, vol. 25, no. 16, pp. 4966-4972. https://doi.org/10.1158/1078-0432.CCR-19-0160
Chen, R, Xia, W, Wang, S, Xu, Y, Ma, Z, Xu, W, Zhang, E, Wang, J, Fang, T, Zhang, Q, Dong, G, Cho, WCS, Ma, PC-C, Brandi, G, Tavolari, S, Ujhazy, P, Metro, G, Popper, HH, Yin, R, Qiu, M & Xu, L 2019, 'Long Noncoding RNA SBF2-AS1 Is Critical for Tumorigenesis of Early-Stage Lung Adenocarcinoma', Molecular Therapy - Nucleic Acids, vol. 16, pp. 543-553. https://doi.org/10.1016/j.omtn.2019.04.004
Morgensztern, D, Rose, M, Waqar, SN, Morris, J, Ma, PC-C, Reid, T, Brzezniak, CE, Zeman, KG, Padmanabhan, A, Hirth, JA, I. Spira, A, Trepel, JB & Padda, SK 2019, 'RRx-001 followed by platinum plus etoposide in patients with previously treated small-cell lung cancer', British Journal of Cancer, vol. 121, no. 3, pp. 211-217. https://doi.org/10.1038/s41416-019-0504-8

2018

Drilon, A, Laetsch, TW, Kummar, S, Dubois, SG, Lassen, UN, Demetri, GD, Nathenson, M, Doebele, RC, Farago, AF, Pappo, AS, Turpin, B, Dowlati, A, Brose, MS, Mascarenhas, L, Federman, N, Berlin, J, El-Deiry, WS, Baik, C, Deeken, J, Boni, V, Nagasubramanian, R, Taylor, M, Rudzinski, ER, Meric-Bernstam, F, Sohal, DPS, Ma, PC-C, Raez, LE, Hechtman, JF, Benayed, R, Ladanyi, M, Tuch, BB, Ebata, K, Cruickshank, S, Ku, NC, Cox, MC, Hawkins, DS, Hong, DS & Hyman, DM 2018, 'Efficacy of larotrectinib in TRK fusion-positive cancers in adults and children', New England Journal of Medicine, vol. 378, no. 8, pp. 731-739. https://doi.org/10.1056/NEJMoa1714448
Oronsky, B, Ma, PC-C, Reid, TR, Cabrales, P, Lybeck, M, Oronsky, A, Oronsky, N & Carter, CA 2018, 'Navigating the “No Man's Land” of TKI-Failed EGFR-Mutated Non–Small Cell Lung Cancer (NSCLC): A Review', Neoplasia (United States), vol. 20, no. 1, pp. 92-98. https://doi.org/10.1016/j.neo.2017.11.001
Wu, X, Zhu, L & Ma, PC-C 2018, 'Next-Generation Novel Noninvasive Cancer Molecular Diagnostics Platforms Beyond Tissues', American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, no. 38, pp. 964-977. https://doi.org/10.1200/EDBK_199767

2017

Wu, X, Ma, W, Zhou, Q, Yan, H, Lim, ZF, Huang, M, Deng, C, Yu, X, Su, H, Komo, S, Yang, H, Zhang, X, Wen, S, Zhang, Z & Ma, PC-C 2017, 'AXL–GAS6 expression can predict for adverse prognosis in non-small cell lung cancer with brain metastases', Journal of Cancer Research and Clinical Oncology, vol. 143, no. 10, pp. 1947-1957. https://doi.org/10.1007/s00432-017-2408-4
Chaib, I, Karachaliou, N, Pilotto, S, Codony Servat, J, Cai, X, Li, X, Drozdowskyj, A, Servat, CC, Yang, J, Hu, C, Cardona, AF, Vivanco, GL, Vergnenegre, A, Sanchez, JM, Provencio, M, de Marinis, F, Passaro, A, Cao, P, Reguart, N, Campelo, CG, Teixido, C, Sperduti, I, Rodriguez, S, Lazzari, C, Verlicchi, A, de Aguirre, I, Queralt, C, Wei, J, Estrada, R, de la Bellacasa, RP, Ramirez, JL, Jacobsen, K, Ditzel, HJ, Santarpia, M, Viteri, S, Molina, MA, Zhou, C, Cao, P, Ma, PC-C, Bivona, TG & Rosell, R 2017, 'Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC', Journal of the National Cancer Institute, vol. 109, no. 9. https://doi.org/10.1093/jnci/djx014
Boothe, JT, Budd, GT, Smolkin, MB & Ma, PC-C 2017, 'Durable near-complete response to Anti-PD-1 checkpoint immunotherapy in a refractory malignant solitary fibrous tumor of the pleura', Case Reports in Oncology, vol. 10, no. 3, pp. 998-1005. https://doi.org/10.1159/000484041
Oronsky, B, Ma, PC-C, Morgensztern, D & Carter, CA 2017, 'Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas', Neoplasia (United States), vol. 19, no. 12, pp. 991-1002. https://doi.org/10.1016/j.neo.2017.09.002
Ma, PC-C 2017, 'Special issue: "MET as actionable target in cancer therapy"', Annals of Translational Medicine, vol. 5, no. 1, 1. https://doi.org/10.21037/atm.2017.01.10
Pilotto, S, Carbognin, L, Karachaliou, N, Ma, PC-C, Rosell, R, Tortora, G & Bria, E 2017, 'Tracking MET de-addiction in lung cancer: A road towards the oncogenic target', Cancer Treatment Reviews, vol. 60, pp. 1-11. https://doi.org/10.1016/j.ctrv.2017.08.002
Guo, T, Zhao, S, Wang, P, Xue, X, Zhang, Y, Yang, M, Li, N, Li, Z, Xu, L, Jiang, L, Zhao, L, Ma, PC-C, Rosell, R, Li, J & Gu, C 2017, 'YB-1 regulates tumor growth by promoting MACC1/c-Met pathway in human lung adenocarcinoma', Oncotarget, vol. 8, no. 29, pp. 48110-48125. https://doi.org/10.18632/oncotarget.18262

2016

Hembrough, T, Liao, WL, Hartley, CP, Ma, PC-C, Velcheti, V, Lanigan, C, Thyparambil, S, An, E, Monga, M, Krizman, D, Burrows, J & Tafe, LJ 2016, 'Quantification of anaplastic lymphoma kinase protein expression in non-small cell lung cancer tissues from patients treated with crizotinib', Clinical Chemistry, vol. 62, no. 1, pp. 252-261. https://doi.org/10.1373/clinchem.2015.245860
Thiagarajan, PS, Wu, X, Zhang, W, Shi, I, Bagai, R, Leahy, P, Feng, Y, Veigl, M, Lindner, D, Danielpour, D, Yin, L, Rosell, R, Bivona, TG, Zhang, Z & Ma, PC-C 2016, 'Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergeticsmitochondrial priming', Oncotarget, vol. 7, no. 50, pp. 82013-82027. https://doi.org/10.18632/oncotarget.13307

2015

Ma, PC-C 2015, 'Met receptor juxtamembrane exon 14 alternative spliced variant: Novel cancer genomic predictive biomarker', Cancer Discovery, vol. 5, no. 8, pp. 802-805. https://doi.org/10.1158/2159-8290.CD-15-0769
Fu, P, Panneerselvam, A, Clifford, B, Dowlati, A, Ma, PC-C, Zeng, G, Halmos, B & Leidner, RS 2015, 'Simpson's paradox - Aggregating and partitioning populations in health disparities of lung cancer patients', Statistical Methods in Medical Research, vol. 24, no. 6, pp. 937-948. https://doi.org/10.1177/0962280211434179

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)