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Researcher Profile

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Shouhao Zhou, PhD

Shouhao Zhou, PhD

Associate Professor, Department of Public Health Sciences
Assistant Professor, Department of Public Health Sciences
Division of Biostatistics and Bioinformatics
Scientific Program:Next-Generation Therapies

Research Interests

Dr. Shouhao Zhou's research focuses on the development of statistical methods for Bayesian model selection, meta-analysis, biomarker dynamic prediction, clinical trial and experimental design and estimation of drug synergism in combination studies, with applications in leukemia, lymphoma, glioma, imaging and medical physics, among many others.

Dr. Zhou served as co-leader of biostatistics core at Lymphoma SPORE, lead statistician/co-investigator of GBM and B-cell lymphoma moonshot programs at M.D. Anderson Cancer Center, and has held various NIH grants. He has been a statistical consultant and collaborator for academic research in medical sciences for many years and is enthusiastic to develop tailored solutions for both pre-clinical and clinical research that would have significant real-life implications.

  • Therapeutics
  • Neoplasms
  • Survival
  • Glioblastoma
  • Meta-Analysis
  • Neuroendocrine Tumors
  • Breast Neoplasms
  • Clinical Trials
  • Incidence
  • Population
  • Proteins
  • Systematic Reviews

Recent Publications


Kang, DW, Wang, L, Short, NJ, Ferrajoli, A, Wang, Y, Zhou, S & Shen, C 2024, 'Cost Effectiveness of Zanubrutinib Versus Ibrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia', PharmacoEconomics, vol. 42, no. 4, pp. 409-418.
Shen, C, Thornton, JD, Li, N, Schaefer, E, Zhou, S, Kawasaki, S, Pameijer, C & Leslie, D 2024, 'Opioid and Non-Opioid Pharmacotherapy Use for Pain Management Among Privately Insured Pediatric Patients With Cancer in the United States', Oncologist, vol. 29, no. 2, pp. 176-184.


Fang, X & Zhou, S 2024, 'A comparative study of in vitro dose–response estimation under extreme observations', Biometrical Journal, vol. 66, no. 1, 2200092.
Endres, K, Razavi, N, Tian, Z, Zhou, S, Krawiec, C & Jasani, S 2023, 'A retrospective analysis of complications associated with postpartum hemorrhage up to 1 year postpartum in mothers with and without a pre-existing mental health diagnosis', Women's Health, vol. 19.
Lin, D, Thompson, CL, Ba, DM, Muscat, JE, Zhou, S, Rogers, CJ & Sturgeon, KM 2023, 'Associations Between Leisure-Time Physical Activity Level and Peripheral Immune Cell Populations in the US General Population, Analysis of the National Health and Nutrition Examination Survey Data, 1999–2018', Sports Medicine - Open, vol. 9, no. 1, 101.
Zhou, S, Huang, X, Shen, C & Kantarjian, HM 2024, 'Bayesian Learning of Personalized Longitudinal Biomarker Trajectory', Annals of Data Science, vol. 11, no. 3, pp. 1031-1050.
Pearson, C, Piper, M, Bhanja, D, Zhou, S & Burns, A 2023, 'Career satisfaction in women surgeons: A systematic review and meta-analysis', American Journal of Surgery, vol. 226, no. 5, pp. 616-622.
Nachnani, R, Sepulveda, DE, Booth, JL, Zhou, S, Graziane, NM, Raup-Konsavage, WM & Vrana, KE 2023, 'Chronic Cannabigerol as an Effective Therapeutic for Cisplatin-Induced Neuropathic Pain', Pharmaceuticals, vol. 16, no. 10, 1442.
Fu, C, Pang, H, Zhou, S & Zhu, J 2023, 'Covariate handling approaches in combination with dynamic borrowing for hybrid control studies', Pharmaceutical Statistics, vol. 22, no. 4, pp. 619-632.
Zhou, S & Shen, C 2023, 'Efficacy and safety associated with immune checkpoint inhibitors in unresectable hepatocellular carcinoma: A re-analysis of a meta-analysis', JGH Open, vol. 7, no. 2, pp. 163-164.
King, CE, Kells, A, Trout, L, Yirinec, A, Zhou, S & Zurca, AD 2023, 'Gamification educational intervention improves pediatric nurses' comfort and speed drawing up code-dose epinephrine', Journal of Pediatric Nursing, vol. 71, pp. 55-59.
Sinha, N, Tian, Z, Zhou, S, Thomas, NJ & Krawiec, C 2023, 'Multicenter retrospective database evaluation of Takotsubo syndrome in subjects undergoing catheter ablation for atrial fibrillation', Journal of Arrhythmia, vol. 39, no. 3, pp. 359-365.
Zhou, S 2023, 'Posterior Averaging Information Criterion', Entropy, vol. 25, no. 3, 468.
Lennon, RP, Parascando, J, Talbot, SG, Zhou, S, Wasserman, E, Mantri, S, Day, PG, Liu, R, Lagerman, M, Appiah, A, Rabago, D & Dean, W 2023, 'Prevalence of Moral Injury, Burnout, Anxiety, and Depression in Healthcare Workers 2 Years in to the COVID-19 Pandemic', Journal of Nervous and Mental Disease, vol. 211, no. 12, pp. 981-984.
Panganiban, RP, Tuan, A, Hart, M, Pelton, M, Mikhail, D, Akhtar, S, Bogale, K, Deiling, S, Zhou, S, Coates, MD, Yochum, GS & Koltun, W 2023, 'Pyoderma Gangrenosum Is Associated With Increased Risk of Inflammatory Pouch-Related Complications: A Retrospective Cohort Study', Crohn's and Colitis 360, vol. 5, no. 3, otad024.
Fang, X, Liu, X, Chinchilli, VM, Wang, M, Wang, HG, Dokholyan, NV, Shen, C, Lee, JJ & Zhou, S 2023, 'REAP-2: An interactive quantitative tool for robust and efficient dose-response curve estimation', Journal of Clinical and Translational Science, vol. 7, no. 1, e219.
Fritsche, M, Singh, P, Zhou, S & Hollins, LC 2023, 'Racial and Ethnic Disparities Among US Academic Dermatology Leadership and Its Influence on Resident Diversity', Journal of Drugs in Dermatology, vol. 22, no. 7, pp. 653-656.
Hodge, C, Myers, A, Ceneviva, GD, Zhao, R, Zhou, S, Thomas, NJ & Krawiec, C 2023, 'Retrospective Analysis of Sugammadex Use in Adolescent Females on Progestin-Containing Contraceptives', Journal of Pediatric and Adolescent Gynecology, vol. 36, no. 5, pp. 459-464.


Endres, KM, Kierys, K, Shang, Y, Zhou, S, Ceneviva, GD, Thomas, NJ & Krawiec, C 2022, 'A Multicenter Retrospective Evaluation of Specialized Laboratory Investigations in the Workup of Pediatric Patients With New-Onset Supraventricular Tachycardia', Journal of Emergency Nursing, vol. 48, no. 6, pp. 678-687.e1.
Pan, H, Mu, R, Hsu, CW & Zhou, S 2022, 'An R package UnifiedDoseFinding for continuous and ordinal outcomes in Phase I dose-finding trials', Communications for Statistical Applications and Methods, vol. 29, no. 4, pp. 421-439.
Short, NJ, Fu, C, Berry, DA, Walter, RB, Freeman, SD, Hourigan, CS, Huang, X, Gonzalez, GN, Hwang, H, Qi, X, Kantarjian, H, Zhou, S & Ravandi, F 2022, 'Association of hematologic response and assay sensitivity on the prognostic impact of measurable residual disease in acute myeloid leukemia: a systematic review and meta-analysis', Leukemia, vol. 36, no. 12, pp. 2817-2826.
Zhou, S & Shen, C 2022, 'Avoiding Definitive Conclusions in Meta-analysis of Heterogeneous Studies with Small Sample Sizes', JAMA Otolaryngology - Head and Neck Surgery, vol. 148, no. 11, pp. 1003-1004.
Qi, X, Zhou, S, Wang, Y & Peterson, C 2022, 'Bayesian sparse modeling to identify high-risk subgroups in meta-analysis of safety data', Research Synthesis Methods, vol. 13, no. 6, pp. 807-820.
Qi, X, Zhou, S & Plummer, M 2022, 'Correction: On Bayesian modeling of censored data in JAGS (BMC Bioinformatics, (2022), 23, 1, (102), 10.1186/s12859-021-04496-8)', BMC bioinformatics, vol. 23, no. 1, 238.
Wang, Y, Zhou, S, Qi, X, Yang, F, Maurer, MJ, Habermann, TM, Witzig, TE, Wang, ML & Nowakowski, GS 2022, 'Efficacy of front-line immunochemotherapy for follicular lymphoma: a network meta-analysis of randomized controlled trials', Blood Cancer Journal, vol. 12, no. 1, 1.
Shen, C, Li, N, Zhou, S, Stahl, K, Dodge, D & Zhao, H 2023, 'Endocrine therapy initiation and overall survival outcomes with omission of radiation therapy in older Medicare patients with early-stage hormone-receptor-positive breast cancer', Cancer medicine, vol. 12, no. 6, pp. 6935-6944.
Hyczko, AV, Fu, C, Graf, Z, Perkowski, CD, Whyte-Nesfield, MM, Zhou, S & Zurca, AD 2022, 'Evaluating Pediatric Families’ Understanding of and Reactions to COVID-19 Visitor Restrictions', Journal of Patient Experience, vol. 9.
Perkowski, C, Eldridge, B, Zurca, AD, Demartini, TKM, Ceneviva, GD, Williams, D, Fang, X, Zhou, S, Thomas, NJ & Krawiec, C 2022, 'Impact of Pediatric Intensive Care Unit Preadmission Huddle on Perceptions of Interprofessional Communication About Patient Safety', Critical Care Nurse, vol. 42, no. 4, pp. 55-67.
Krawiec, C, Mysore, MR, Mathur, M, Fang, X, Zhou, S, Thomas, NJ & Nakagawa, TA 2022, 'Impact of the Updated Guideline for Pediatric Brain Death Determination on Current Practice', Journal of Child Neurology, vol. 37, no. 7, pp. 553-561.
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969.
Pizzola, CJ, Cioccio, J, Rakszawski, KL, Nickolich, M, Ehmann, WC, Rybka, WB, Wirk, B, Naik, S, Zheng, H, Silar, B, Shike, H, Zhou, S, Mineishi, S, Minagawa, K & Claxton, DF 2022, 'Non-myeloablative allogeneic stem cell transplant with fludarabine and reduced dose cyclophosphamide in acute myeloid leukemia for older adults with comorbidities', Bone Marrow Transplantation, vol. 57, no. 11, pp. 1743-1745.
Qi, X, Zhou, S & Plummer, M 2022, 'On Bayesian modeling of censored data in JAGS', BMC bioinformatics, vol. 23, no. 1, 102.
Shen, C, Tannenbaum, D, Horn, R, Rogers, J, Eng, C, Zhou, S, Johnson, B, Kopetz, S, Morris, V, Overman, M, Parseghian, C, Chang, GJ, Lopez-Olivo, MA, Kanwal, R, Ellis, LM & Dasari, A 2022, 'Overall Survival in Phase 3 Clinical Trials and the Surveillance, Epidemiology, and End Results Database in Patients with Metastatic Colorectal Cancer, 1986-2016: A Systematic Review', JAMA network open.
Shen, C, Jain, K, Shah, T, Schaefer, E, Zhou, S, Fried, D, Helmer, DA & Sadeghi-Nejad, H 2022, 'Relationships between erectile dysfunction, prostate cancer treatment type and inflatable penile prosthesis implantation', Investigative and Clinical Urology, vol. 63, no. 3, pp. 316-324.
Zhou, S, Liu, X, Fang, X, Chinchilli, VM, Wang, M, Wang, HG, Dokholyan, NV, Shen, C & Lee, JJ 2022, 'Robust and Efficient Assessment of Potency (REAP) as a quantitative tool for dose-response curve estimation', eLife, vol. 11, e78634.
Gandhi, CK, Thomas, NJ, Meixia, Y, Spear, D, Fu, C, Zhou, S, Wu, R, Keim, G, Yehya, N & Floros, J 2022, 'SNP–SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children', Frontiers in Genetics, vol. 13, 815727.
Nastoupil, LJ, Chin, CK, Westin, JR, Fowler, NH, Samaniego, F, Cheng, X, Ma, MCJ, Wang, Z, Chu, F, Dsouza, L, Obi, C, Mims, J, Feng, L, Zhou, S, Green, M, Davis, RE & Neelapu, SS 2022, 'Safety and activity of pembrolizumab in combination with rituximab in relapsed or refractory follicular lymphoma', Blood Advances, vol. 6, no. 4, pp. 1143-1151.
Anselmi, L, Kim, JS, Kaufman, MP, Zhou, S & Ruiz-Velasco, V 2022, 'Serotonin-Mediated Activation of Serotonin Receptor Type 1 Oppositely Modulates Voltage-Gated Calcium Channel Currents in Rat Sensory Neurons Innervating Hindlimb Muscle', Molecular pharmacology, vol. 101, no. 5, pp. 309-321.
Zhou, S & Shen, C 2022, 'Statistical Considerations for Meta-analysis of Diabetic Retinopathy Prevalence', JAMA Ophthalmology, vol. 140, no. 11, pp. 1141.
Zhou, S & Shen, C 2022, 'Statistical concerns for meta-analysis of rare events and small sample sizes', The Lancet Infectious Diseases, vol. 22, no. 8, pp. 1111-1112.
Shen, C, Holguin, RAP, Schaefer, E, Zhou, S, Belani, CP, Ma, PC & Reed, MF 2022, 'Utilization and costs of epidermal growth factor receptor mutation testing and targeted therapy in Medicare patients with metastatic lung adenocarcinoma', BMC health services research, vol. 22, no. 1, 470.
Shen, C, Kwon, M, Moss, JL, Schaefer, E, Zhou, S, Dodge, D & Ruffin, MT 2022, 'Utilization of Mammography During the Last Year of Life Among Older Breast Cancer Survivors', Journal of Women's Health, vol. 31, no. 7, pp. 941-948.
Camargo, A, Zacharia, T, Kanekar, S, Bruno, M, Tian, Z, Zhou, S & Yousem, DM 2023, 'Value of CTA/MRA in the setting of intraparenchymal hemorrhage in the emergency department', Neuroradiology, vol. 65, no. 1, pp. 97-103.


Liu, W, Lopez, G, Narayanan, S, Qdaisat, A, Geng, Y, Zhou, S, Spano, M, Underwood, S, Eclache, MG, Dev, R, Dalal, S, Bruera, E & Cohen, L 2021, 'Acupuncture for Cancer-Related Anorexia: a Review of the Current Evidence', Current oncology reports, vol. 23, no. 7, 82.
Shen, C, Klein, RW, Moss, JL, Dodge, DG, Chetlen, AL, Stahl, KA, Zhou, S, Leslie, DL, Ruffin, MT & Lengerich, EJ 2021, 'Association Between Dense Breast Legislation and Cancer Stage at Diagnosis', American Journal of Preventive Medicine, vol. 61, no. 6, pp. 890-899.
Patel, SN, Lee, C, Cui, D, Wingert, AM, Zhou, S & Scott, IU 2022, 'Association of staffing with Incidence of delayed retinal break or detachment after posterior vitreous detachment in a resident urgent care clinic', Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 260, no. 3, pp. 791-798.
Ehret, CJ, Zhou, S, Tchou, JC, Schmitz, KH & Sturgeon, KM 2022, 'Dose-dependent effects of aerobic exercise on clinically relevant biomarkers among healthy women at high genetic risk for breast cancer: A secondary analysis of a randomized controlled study', Cancer Reports, vol. 5, no. 5, e1497.
Perkowski, C, Schlueter, D, Zhou, S, Ceneviva, GD, Thomas, NJ & Krawiec, C 2022, 'Factors Influencing Pregnancy Screening in the Pediatric Intensive Care Unit', Journal of Pediatric and Adolescent Gynecology, vol. 35, no. 1, pp. 59-64.
Krawiec, C, Fang, X, Zhou, S, Williams, D & Thomas, NJ 2021, 'Frequency of persistent obesity 5 years after first time diagnosis of status asthmaticus', Clinical Respiratory Journal, vol. 15, no. 12, pp. 1368-1374.
Nguyen, H, Shah, K, Waguespack, SG, Hu, MI, Habra, MA, Cabanillas, ME, Busaidy, NL, Bassett, R, Zhou, S, Iyer, PC, Simmons, G, Kaya, D, Pitteloud, M, Subudhi, SK, Diab, A & Dadu, R 2021, 'Immune checkpoint inhibitor related hypophysitis: Diagnostic criteria and recovery patterns', Endocrine-Related Cancer, vol. 28, no. 7, pp. 419-431.
Krawiec, C, Ceneviva, GD, Zhou, S & Thomas, NJ 2021, 'Impact of a Severe Rocky Mountain Spotted Fever Case on Treatment Practices at an Academic Institution Within a Nonendemic Area', Wilderness and Environmental Medicine, vol. 32, no. 4, pp. 427-432.
Ravandi, F, Zhou, S & Short, N 2021, 'In reply', JAMA Oncology, vol. 7, no. 5, pp. 784-785.
Gandhi, CK, Chen, C, Amatya, S, Yang, L, Fu, C, Zhou, S, Wu, R, Buendía-Roldan, I, Selman, M, Pardo, A & Floros, J 2021, 'SNP and Haplotype Interaction Models Reveal Association of Surfactant Protein Gene Polymorphisms With Hypersensitivity Pneumonitis of Mexican Population', Frontiers in Medicine, vol. 7, 588404.
Purushothaman, I, Zagon, IS, Sassani, JW, Zhou, S & McLaughlin, PJ 2021, 'Sex differences in the magnitude of diabetic ocular surface complications: Role of serum OGF', Physiology and Behavior, vol. 237, 113436.


Short, NJ, Zhou, S, Fu, C, Berry, DA, Walter, RB, Freeman, SD, Hourigan, CS, Huang, X, Nogueras Gonzalez, G, Hwang, H, Qi, X, Kantarjian, H & Ravandi, F 2020, 'Association of Measurable Residual Disease with Survival Outcomes in Patients with Acute Myeloid Leukemia: A Systematic Review and Meta-analysis', JAMA Oncology, vol. 6, no. 12, pp. 1890-1899.
Freiberg, AS & Zhou, S 2020, 'Celestial Versus Terrestrial Travel—An Analysis of Spaceflight Fatalities and Comparison to Other Modes of Transportation', American Journal of Medicine, vol. 133, no. 11, pp. 1274-1279.
Batth, IS, Dao, L, Satelli, A, Mitra, A, Yi, S, Noh, H, Li, H, Brownlee, Z, Zhou, S, Bond, J, Wang, J, Gill, J, Sholler, GS & Li, S 2020, 'Cell surface vimentin-positive circulating tumor cell-based relapse prediction in a long-term longitudinal study of postremission neuroblastoma patients', International Journal of Cancer, vol. 147, no. 12, pp. 3550-3559.
Qdaisat, A, Kamal, M, Al-Breiki, A, Goswami, B, Wu, CC, Zhou, S, Rice, TW, Alagappan, K & Yeung, SCJ 2020, 'Clinical characteristics, management, and outcome of incidental pulmonary embolism in cancer patients', Blood Advances, vol. 4, no. 8, pp. 1606-1614.
Popnoe, DO, Ng, CS, Zhou, S, Kaur, H, Kang, HC, Loyer, EM, Kappadath, SC & Jones, AK 2020, 'Comparison of virtual to true unenhanced abdominal computed tomography images acquired using rapid kV-switching dual energy imaging', PloS one, vol. 15, no. 9 September, e0238582.
Krawiec, C, Ceneviva, GD, Zhou, S & Thomas, N 2020, 'Evaluating the Utility of Toxicologic Analysis in Pediatric Out-of-Hospital Cardiac Arrest', Journal of Emergency Medicine, vol. 59, no. 5, pp. e167-e174.
Shen, C, Gu, D, Klein, R, Zhou, S, Shih, YCT, Tracy, T, Soybel, D & Dillon, P 2020, 'Factors Associated With Hospital Decisions to Purchase Robotic Surgical Systems', MDM Policy and Practice, vol. 5, no. 1.
Hill, HA, Qi, X, Jain, P, Nomie, K, Wang, Y, Zhou, S & Wang, ML 2020, 'Genetic mutations and features of mantle cell lymphoma: A systematic review and meta-analysis', Blood Advances, vol. 4, no. 13, pp. 2927-2938.
Liu, W, Qdaisat, A, Zhou, S, Fuller, CD, Ferrarotto, R, Guo, M, Lai, SY, Cardoso, R, Mohamed, ASR, Lopez, G, Narayanan, S, van Dijk, LV, Cohen, L, Bruera, E, Yeung, SCJ & Hanna, EY 2021, 'Hypomagnesemia and incidence of osteoradionecrosis in patients with head and neck cancers', Head and Neck, vol. 43, no. 2, pp. 613-621.
Horn, SR, Stoltzfus, KC, Mackley, HB, Lehrer, EJ, Zhou, S, Dandekar, SC, Fox, EJ, Rizk, EB, Trifiletti, DM, Rao, PM & Zaorsky, NG 2020, 'Long-term causes of death among pediatric patients with cancer', Cancer, vol. 126, no. 13, pp. 3102-3113.
Ssentongo, AE, Kwon, EG, Zhou, S, Ssentongo, P & Soybel, D 2020, 'Pain and Dysfunction with Sexual Activity after Inguinal Hernia Repair: Systematic Review and Meta-Analysis', Journal of the American College of Surgeons, vol. 230, no. 2, pp. 237-250.e7.
Al-Holou, WN, Hodges, TR, Everson, RG, Freeman, J, Zhou, S, Suki, D, Rao, G, Ferguson, SD, Heimberger, AB, McCutcheon, IE, Prabhu, SS, Lang, FF, Weinberg, JS, Wildrick, DM & Sawaya, R 2020, 'Perilesional Resection of Glioblastoma Is Independently Associated With Improved Outcomes', Neurosurgery, vol. 86, no. 1, pp. 112-121.
Shen, C, Thornton, JD, Gu, D, Dodge, D, Zhou, S, He, W, Zhao, H & Giordano, SH 2020, 'Prolonged Opioid Use After Surgery for Early-Stage Breast Cancer', Oncologist, vol. 25, no. 10, pp. e1574-e1582.
Abudayyeh, A, Song, J, Abdelrahim, M, Dahbour, I, Page, VD, Zhou, S, Shen, C, Zhao, B, Pai, RN, Amaram-Davila, J, Manzano, JG, George, MC, Yennu, S, Mandayam, SA, Nates, JL & Moss, AH 2020, 'Renal Replacement Therapy in Patients With Stage IV Cancer Admitted to the Intensive Care Unit With Acute Kidney Injury at a Comprehensive Cancer Center Was Not Associated With Survival', American Journal of Hospice and Palliative Medicine, vol. 37, no. 9, pp. 707-715.
Shen, C, Thornton, JD, Newport, K, Schaefer, E, Zhou, S, Yee, NS, Dodge, D & Leslie, D 2020, 'Trends and patterns in the use of opioids among metastatic breast cancer patients', Scientific reports, vol. 10, no. 1, 21698.
De Groot, J, Penas-Prado, M, Alfaro-Munoz, K, Hunter, K, Pei, BL, O'Brien, B, Weathers, SP, Loghin, M, Kamiya Matsouka, C, Yung, WKA, Mandel, J, Wu, J, Yuan, Y, Zhou, S, Fuller, GN, Huse, J, Rao, G, Weinberg, JS, Prabhu, SS, McCutcheon, IE, Lang, FF, Ferguson, SD, Sawaya, R, Colen, R, Yadav, SS, Blando, J, Vence, L, Allison, J, Sharma, P & Heimberger, AB 2020, 'Window-of-opportunity clinical trial of pembrolizumab in patients with recurrent glioblastoma reveals predominance of immune-suppressive macrophages', Neuro-oncology, vol. 22, no. 4, pp. 539-549.