Justin Pritchard - Penn State Cancer Institute
Researcher Profile
Justin Pritchard
Associate Professor, Biomedical Engineering
Assistant Professor, Biomedical Engineering
Center for Infectious Disease Dynamics
Assistant Professor, Biomedical Engineering
Center for Infectious Disease Dynamics
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2024
Leighow, SM, Reynolds, JA, Sokirniy, I, Yao, S, Yang, Z, Inam, H, Wodarz, D, Archetti, M & Pritchard, J 2024, 'Programming tumor evolution with selection gene drives to proactively combat drug resistance', Nature Biotechnology. https://doi.org/10.1038/s41587-024-02271-7
2023
Reynolds, JA, Vishweshwaraiah, YL, Chirasani, VR, Pritchard, JR & Dokholyan, NV 2023, 'An engineered N-acyltransferase-LOV2 domain fusion protein enables light-inducible allosteric control of enzymatic activity', Journal of Biological Chemistry, vol. 299, no. 4, 103069. https://doi.org/10.1016/j.jbc.2023.103069
Lawanprasert, A, Sloand, JN, González Vargas, M, Singh, H, Eldor, T, Miller, MA, Pimcharoen, S, Wang, J, Leighow, SM, Pritchard, JR, Dokholyan, NV & Medina, SH 2023, 'Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions', ChemBioChem, vol. 24, no. 13, e202300159. https://doi.org/10.1002/cbic.202300159
Liu, C, Leighow, SM, McIlroy, K, Lu, M, Dennis, KA, Abello, K, Brown, DJ, Moore, CJ, Shah, A, Inam, H, Rivera, VM & Pritchard, JR 2023, 'Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing', Cell Reports Medicine, vol. 4, no. 10, 101227. https://doi.org/10.1016/j.xcrm.2023.101227
Halder, R, Nissley, DA, Sitarik, I, Jiang, Y, Rao, Y, Vu, QV, Li, MS, Pritchard, J & O’Brien, EP 2023, 'How soluble misfolded proteins bypass chaperones at the molecular level', Nature communications, vol. 14, no. 1, 3689. https://doi.org/10.1038/s41467-023-38962-z
Rao, Y, Ahmed, N, Pritchard, J & O’Brien, EP 2023, 'Incorporating mutational heterogeneity to identify genes that are enriched for synonymous mutations in cancer', BMC bioinformatics, vol. 24, no. 1, 462. https://doi.org/10.1186/s12859-023-05521-8
Yeware, A, Helton, A, Dong, Y, Dong, C, Pritchard, J, Mineishi, S, Minagawa, K, Schell, T & Hayes, D 2023, 'Novel fourth generation-like CARmiR cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity', Biochemical Engineering Journal, vol. 199, 109068. https://doi.org/10.1016/j.bej.2023.109068
Kreger, J, Brown, D, Komarova, NL, Wodarz, D & Pritchard, J 2023, 'The role of migration in mutant dynamics in fragmented populations', Journal of Evolutionary Biology, vol. 36, no. 2, pp. 444-460. https://doi.org/10.1111/jeb.14131
2022
Zhao, B, Rao, Y, Leighow, S, O’Brien, EP, Gilbert, L & Pritchard, JR 2022, 'A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments', Nature communications, vol. 13, no. 1, 625. https://doi.org/10.1038/s41467-022-28045-w
Leighow, SM, Landry, B, Lee, MJ, Peyton, SR & Pritchard, JR 2022, 'Agent-Based Models Help Interpret Patterns of Clinical Drug Resistance by Contextualizing Competition Between Distinct Drug Failure Modes', Cellular and Molecular Bioengineering, vol. 15, no. 5, pp. 521-533. https://doi.org/10.1007/s12195-022-00748-6
Pritchard, JR, Lee, MJ & Peyton, SR 2022, 'Materials-driven approaches to understand extrinsic drug resistance in cancer', Soft matter, vol. 18, no. 18, pp. 3465-3472. https://doi.org/10.1039/d2sm00071g
George, S, von Mehren, M, Fletcher, JA, Sun, J, Zhang, S, Pritchard, JR, Hodgson, JG, Kerstein, D, Rivera, VM, Haluska, FG & Heinrich, MC 2022, 'Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers', Clinical Cancer Research, vol. 28, no. 7, pp. 1268-1276. https://doi.org/10.1158/1078-0432.CCR-21-2037
Tran, TNA, Wikle, NB, Yang, F, Inam, H, Leighow, S, Gentilesco, B, Chan, P, Albert, E, Strong, ER, Pritchard, JR, Hanage, WP, Hanks, EM, Crawford, FW & Boni, MF 2022, 'SARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 2021', JAMA network open, vol. 5, no. 5, pp. E2214171. https://doi.org/10.1001/jamanetworkopen.2022.14171
Wikle, NB, Nguyen-Anh Tran, T, Gentilesco, B, Leighow, SM, Albert, E, Strong, ER, Brinda, K, Inam, H, Yang, F, Hossain, S, Chan, P, Hanage, WP, Messick, M, Pritchard, JR, Hanks, EM & Boni, MF 2022, 'SARS-CoV-2 epidemic after social and economic reopening in three U.S. states reveals shifts in age structure and clinical characteristics', Science Advances, vol. 8, no. 4, eabf9868. https://doi.org/10.1126/sciadv.abf9868
Marloye, M, Inam, H, Moore, CJ, Mertens, TR, Ingels, A, Koch, M, Nowicki, MO, Mathieu, V, Pritchard, JR, Awuah, SG, Lawler, SE, Meyer, F, Dufrasne, F & Berger, G 2022, 'Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity', Inorganic Chemistry Frontiers, vol. 9, no. 11, pp. 2594-2607. https://doi.org/10.1039/d2qi00423b
Hospodiuk-Karwowski, M, Chi, K, Pritchard, J & Catchmark, JM 2022, 'Vascularized pancreas-on-a-chip device produced using a printable simulated extracellular matrix', Biomedical Materials (Bristol), vol. 17, no. 6, 065006. https://doi.org/10.1088/1748-605X/ac8c74
2021
Yogodzinski, C, Arab, A, Pritchard, JR, Goodarzi, H & Gilbert, LA 2021, 'A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy', Genome Medicine, vol. 13, no. 1, 167. https://doi.org/10.1186/s13073-021-00987-8
Inam, H, Sokirniy, I, Rao, Y, Shah, A, Naeemikia, F, O'Brien, E, Dong, C, McCandlish, DM & Pritchard, JR 2021, 'Genomic and experimental evidence that ALKATI does not predict single agent sensitivity to ALK inhibitors', iScience, vol. 24, no. 11, 103343. https://doi.org/10.1016/j.isci.2021.103343
Dowling, CM, Hollinshead, KER, Di Grande, A, Pritchard, J, Zhang, H, Dillon, ET, Haley, K, Papadopoulos, E, Mehta, AK, Bleach, R, Lindner, AU, Mooney, B, Düssmann, H, O'Connor, D, Prehn, JHM, Wynne, K, Hemann, M, Bradner, JE, Kimmelman, AC, Guerriero, JL, Cagney, G, Wong, KK, Letai, AG & Chonghaile, TN 2021, 'Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer', Science Advances, vol. 7, no. 3, eabc4897. https://doi.org/10.1126/sciadv.abc4897
Tran, TNA, Wikle, NB, Albert, E, Inam, H, Strong, E, Brinda, K, Leighow, SM, Yang, F, Hossain, S, Pritchard, JR, Chan, P, Hanage, WP, Hanks, EM & Boni, MF 2021, 'Optimal SARS-CoV-2 vaccine allocation using real-time attack-rate estimates in Rhode Island and Massachusetts', BMC Medicine, vol. 19, no. 1, 162. https://doi.org/10.1186/s12916-021-02038-w
Hullahalli, K, Pritchard, JR & Waldor, MK 2021, 'Refined quantification of infection bottlenecks and pathogen dissemination with STAMPR', mSystems, vol. 6, no. 4, e00887-21. https://doi.org/10.1128/mSystems.00887-21
Marloye, M, Inam, H, Moore, CJ, Debaille, V, Pritchard, JR, Gelbcke, M, Meyer, F, Dufrasne, F & Berger, G 2021, 'Synthesis, structure and anticancer properties of new biotin- and morpholine-functionalized ruthenium and osmium half-sandwich complexes', Journal of Biological Inorganic Chemistry, vol. 26, no. 5, pp. 535-549. https://doi.org/10.1007/s00775-021-01873-9
2020
Leighow, SM, Liu, C, Inam, H, Zhao, B & Pritchard, JR 2020, 'Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design', Cell Reports, vol. 30, no. 12, pp. 3951-3963.e4. https://doi.org/10.1016/j.celrep.2020.02.108
Bruno, PM, Lu, M, Dennis, KA, Inam, H, Moore, CJ, Sheehe, J, Elledge, SJ, Hemann, MT & Pritchard, JR 2020, 'The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 8, pp. 4053-4060. https://doi.org/10.1073/pnas.1921649117
Short, NJ, Kantarjian, H, Kanagal-Shamanna, R, Sasaki, K, Ravandi, F, Cortes, J, Konopleva, M, Issa, GC, Kornblau, SM, Garcia-Manero, G, Garris, R, Higgins, J, Pratt, G, Williams, LN, Valentine, CC, Rivera, VM, Pritchard, J, Salk, JJ, Radich, J & Jabbour, E 2020, 'Ultra-accurate Duplex Sequencing for the assessment of pretreatment ABL1 kinase domain mutations in Ph+ ALL', Blood Cancer Journal, vol. 10, no. 5, 61. https://doi.org/10.1038/s41408-020-0329-y