Researcher Profile

Researcher Profile

Justin Pritchard

Justin Pritchard

Assistant Professor, Biomedical Engineering
Scientific Program:Mechanisms of Carcinogenesis
jrp94@psu.edu

Research Interests

  • Neoplasms
  • Therapeutics
  • Pharmaceutical Preparations
  • Growth
  • Genes
  • Genome
  • Mutation
  • Leukemia
  • Drug Resistance
  • Drug Combinations
  • Mycobacterium
  • Small Interfering RNA

Recent Publications

2018

Laencina, L, Dubois, V, Le Moigne, V, Viljoen, A, Majlessi, L, Pritchard, J, Bernut, A, Piel, L, Roux, AL, Gaillard, JL, Lombard, B, Loew, D, Rubin, EJ, Brosch, R, Kremer, L, Herrmann, JL & Girard-Misguich, F 2018, 'Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 5, pp. E1002-E1011. https://doi.org/10.1073/pnas.1713195115
Gozgit, JM, Chen, TH, Song, Y, Wardwell, S, Wang, F, Cai, J, Li, H, Edgren, H, Rivera, VM & Pritchard, J 2018, 'RET fusions observed in lung and colorectal cancers are sensitive to ponatinib', Oncotarget, vol. 9, no. 51, pp. 29654-29664. https://doi.org/10.18632/oncotarget.25664
Schmitt, MW, Pritchard, J, Leighow, SM, Aminov, BI, Beppu, L, Kim, DS, Hodgson, JG, Rivera, VM, Loeb, LA & Radich, JP 2018, 'Single-molecule sequencing reveals patterns of preexisting drug resistance that suggest treatment strategies in Philadelphia-positive leukemias', Clinical Cancer Research, vol. 24, no. 21, pp. 5321-5334. https://doi.org/10.1158/1078-0432.CCR-18-0167

2017

Bruno, PM, Liu, Y, Park, GY, Murai, J, Koch, CE, Eisen, TJ, Pritchard, J, Pommier, Y, Lippard, SJ & Hemann, MT 2017, 'A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress', Nature Medicine, vol. 23, no. 4, pp. 461-471. https://doi.org/10.1038/nm.4291
Rock, JM, Hopkins, FF, Chavez, A, Diallo, M, Chase, MR, Gerrick, ER, Pritchard, J, Church, GM, Rubin, EJ, Sassetti, CM, Schnappinger, D & Fortune, SM 2017, 'Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform', Nature Microbiology, vol. 2, 16274. https://doi.org/10.1038/nmicrobiol.2016.274

2016

Zhao, B, Sedlak, JC, Srinivas, R, Creixell, P, Pritchard, J, Tidor, B, Lauffenburger, DA & Hemann, MT 2016, 'Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution', Cell, vol. 165, no. 1, pp. 234-246. https://doi.org/10.1016/j.cell.2016.01.045
Zhao, B & Pritchard, J 2016, 'Inherited Disease Genetics Improves the Identification of Cancer-Associated Genes', PLoS genetics, vol. 12, no. 6, e1006081. https://doi.org/10.1371/journal.pgen.1006081

2015

Meacham, CE, Lawton, LN, Soto-Feliciano, YM, Pritchard, J, Joughin, BA, Ehrenberger, T, Fenouille, N, Zuber, J, Williams, RT, Young, RA & Hemann, MT 2015, 'A genome-scale in vivo loss-of-function screen identifies phf6 as a lineage-specific regulator of leukemia cell growth', Genes and Development, vol. 29, no. 5, pp. 483-488. https://doi.org/10.1101/gad.254151.114
Baker, T, Nerle, S, Pritchard, J, Zhao, B, Rivera, VM, Garner, A & Gonzalvez, F 2015, 'Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors', Oncotarget, vol. 6, no. 32, pp. 32646-32655. https://doi.org/10.18632/oncotarget.5066

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