Researcher Profile

Researcher Profile

Justin Pritchard

Justin Pritchard

Assistant Professor, Biomedical Engineering
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Neoplasms
  • Therapeutics
  • Pharmaceutical Preparations
  • Mutation
  • Growth
  • Drug Resistance
  • Genes
  • Leukemia
  • Genome
  • Phosphotransferases
  • Drug Combinations
  • Datasets

Recent Publications


Leighow, SM, Liu, C, Inam, H, Zhao, B & Pritchard, JR 2020, 'Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design', Cell Reports, vol. 30, no. 12, pp. 3951-3963.e4.
Bruno, PM, Lu, M, Dennis, KA, Inam, H, Moore, CJ, Sheehe, J, Elledge, SJ, Hemann, MT & Pritchard, JR 2020, 'The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 8, pp. 4053-4060.
Short, NJ, Kantarjian, H, Kanagal-Shamanna, R, Sasaki, K, Ravandi, F, Cortes, J, Konopleva, M, Issa, GC, Kornblau, SM, Garcia-Manero, G, Garris, R, Higgins, J, Pratt, G, Williams, LN, Valentine, CC, Rivera, VM, Pritchard, J, Salk, JJ, Radich, J & Jabbour, E 2020, 'Ultra-accurate Duplex Sequencing for the assessment of pretreatment ABL1 kinase domain mutations in Ph+ ALL', Blood Cancer Journal, vol. 10, no. 5, 61.


Zhao, B & Pritchard, JR 2019, 'Evolution of the nonsense-mediated decay pathway is associated with decreased cytolytic immune infiltration', PLoS computational biology, vol. 15, no. 10, e1007467.


Laencina, L, Dubois, V, Le Moigne, V, Viljoen, A, Majlessi, L, Pritchard, J, Bernut, A, Piel, L, Roux, AL, Gaillard, JL, Lombard, B, Loew, D, Rubin, EJ, Brosch, R, Kremer, L, Herrmann, JL & Girard-Misguich, F 2018, 'Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 5, pp. E1002-E1011.
Gozgit, JM, Chen, TH, Song, Y, Wardwell, S, Wang, F, Cai, J, Li, H, Edgren, H, Rivera, VM & Pritchard, J 2018, 'RET fusions observed in lung and colorectal cancers are sensitive to ponatinib', Oncotarget, vol. 9, no. 51, pp. 29654-29664.
Schmitt, MW, Pritchard, JR, Leighow, SM, Aminov, BI, Beppu, L, Kim, DS, Hodgson, JG, Rivera, VM, Loeb, LA & Radich, JP 2018, 'Single-molecule sequencing reveals patterns of preexisting drug resistance that suggest treatment strategies in Philadelphia-positive leukemias', Clinical Cancer Research, vol. 24, no. 21, pp. 5321-5334.


Bruno, PM, Liu, Y, Park, GY, Murai, J, Koch, CE, Eisen, TJ, Pritchard, JR, Pommier, Y, Lippard, SJ & Hemann, MT 2017, 'A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress', Nature Medicine, vol. 23, no. 4, pp. 461-471.
Rock, JM, Hopkins, FF, Chavez, A, Diallo, M, Chase, MR, Gerrick, ER, Pritchard, JR, Church, GM, Rubin, EJ, Sassetti, CM, Schnappinger, D & Fortune, SM 2017, 'Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform', Nature Microbiology, vol. 2, 16274.


Zhao, B, Sedlak, JC, Srinivas, R, Creixell, P, Pritchard, JR, Tidor, B, Lauffenburger, DA & Hemann, MT 2016, 'Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution', Cell, vol. 165, no. 1, pp. 234-246.
Zhao, B & Pritchard, JR 2016, 'Inherited Disease Genetics Improves the Identification of Cancer-Associated Genes', PLoS genetics, vol. 12, no. 6, e1006081.

Clinical Trials Search

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