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Justin Pritchard

Justin Pritchard

Associate Professor, Biomedical Engineering
Assistant Professor, Biomedical Engineering
Center for Infectious Disease Dynamics
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Neoplasms
  • Therapeutics
  • Pharmaceutical Preparations
  • Mutation
  • Drug Resistance
  • Growth
  • Genes
  • Population
  • Genome
  • SARS Virus
  • Infections
  • Leukemia

Recent Publications


Reynolds, JA, Vishweshwaraiah, YL, Chirasani, VR, Pritchard, JR & Dokholyan, NV 2023, 'An engineered N-acyltransferase-LOV2 domain fusion protein enables light-inducible allosteric control of enzymatic activity', Journal of Biological Chemistry, vol. 299, no. 4, 103069.
Lawanprasert, A, Sloand, JN, González Vargas, M, Singh, H, Eldor, T, Miller, MA, Pimcharoen, S, Wang, J, Leighow, SM, Pritchard, JR, Dokholyan, NV & Medina, SH 2023, 'Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions', ChemBioChem, vol. 24, no. 13, e202300159.
Liu, C, Leighow, SM, McIlroy, K, Lu, M, Dennis, KA, Abello, K, Brown, DJ, Moore, CJ, Shah, A, Inam, H, Rivera, VM & Pritchard, JR 2023, 'Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing', Cell Reports Medicine, vol. 4, no. 10, 101227.
Halder, R, Nissley, DA, Sitarik, I, Jiang, Y, Rao, Y, Vu, QV, Li, MS, Pritchard, J & O’Brien, EP 2023, 'How soluble misfolded proteins bypass chaperones at the molecular level', Nature communications, vol. 14, no. 1, 3689.
Rao, Y, Ahmed, N, Pritchard, J & O’Brien, EP 2023, 'Incorporating mutational heterogeneity to identify genes that are enriched for synonymous mutations in cancer', BMC bioinformatics, vol. 24, no. 1, 462.
Yeware, A, Helton, A, Dong, Y, Dong, C, Pritchard, J, Mineishi, S, Minagawa, K, Schell, T & Hayes, D 2023, 'Novel fourth generation-like CARmiR cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity', Biochemical Engineering Journal, vol. 199, 109068.
Kreger, J, Brown, D, Komarova, NL, Wodarz, D & Pritchard, J 2023, 'The role of migration in mutant dynamics in fragmented populations', Journal of Evolutionary Biology, vol. 36, no. 2, pp. 444-460.


Zhao, B, Rao, Y, Leighow, S, O’Brien, EP, Gilbert, L & Pritchard, JR 2022, 'A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments', Nature communications, vol. 13, no. 1, 625.
Leighow, SM, Landry, B, Lee, MJ, Peyton, SR & Pritchard, JR 2022, 'Agent-Based Models Help Interpret Patterns of Clinical Drug Resistance by Contextualizing Competition Between Distinct Drug Failure Modes', Cellular and Molecular Bioengineering, vol. 15, no. 5, pp. 521-533.
Pritchard, JR, Lee, MJ & Peyton, SR 2022, 'Materials-driven approaches to understand extrinsic drug resistance in cancer', Soft matter.
George, S, von Mehren, M, Fletcher, JA, Sun, J, Zhang, S, Pritchard, JR, Hodgson, JG, Kerstein, D, Rivera, VM, Haluska, FG & Heinrich, MC 2022, 'Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers', Clinical Cancer Research, vol. 28, no. 7, pp. 1268-1276.
Tran, TNA, Wikle, NB, Yang, F, Inam, H, Leighow, S, Gentilesco, B, Chan, P, Albert, E, Strong, ER, Pritchard, JR, Hanage, WP, Hanks, EM, Crawford, FW & Boni, MF 2022, 'SARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 2021', JAMA network open, vol. 5, no. 5, pp. E2214171.
Wikle, NB, Nguyen-Anh Tran, T, Gentilesco, B, Leighow, SM, Albert, E, Strong, ER, Brinda, K, Inam, H, Yang, F, Hossain, S, Chan, P, Hanage, WP, Messick, M, Pritchard, JR, Hanks, EM & Boni, MF 2022, 'SARS-CoV-2 epidemic after social and economic reopening in three U.S. states reveals shifts in age structure and clinical characteristics', Science Advances, vol. 8, no. 4, eabf9868.
Marloye, M, Inam, H, Moore, CJ, Mertens, TR, Ingels, A, Koch, M, Nowicki, MO, Mathieu, V, Pritchard, JR, Awuah, SG, Lawler, SE, Meyer, F, Dufrasne, F & Berger, G 2022, 'Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity', Inorganic Chemistry Frontiers.
Hospodiuk-Karwowski, M, Chi, K, Pritchard, J & Catchmark, JM 2022, 'Vascularized pancreas-on-a-chip device produced using a printable simulated extracellular matrix', Biomedical Materials (Bristol), vol. 17, no. 6, 065006.


Yogodzinski, C, Arab, A, Pritchard, JR, Goodarzi, H & Gilbert, LA 2021, 'A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy', Genome Medicine, vol. 13, no. 1, 167.
Inam, H, Sokirniy, I, Rao, Y, Shah, A, Naeemikia, F, O'Brien, E, Dong, C, McCandlish, DM & Pritchard, JR 2021, 'Genomic and experimental evidence that ALKATI does not predict single agent sensitivity to ALK inhibitors', iScience, vol. 24, no. 11, 103343.
Dowling, CM, Hollinshead, KER, Di Grande, A, Pritchard, J, Zhang, H, Dillon, ET, Haley, K, Papadopoulos, E, Mehta, AK, Bleach, R, Lindner, AU, Mooney, B, Düssmann, H, O'Connor, D, Prehn, JHM, Wynne, K, Hemann, M, Bradner, JE, Kimmelman, AC, Guerriero, JL, Cagney, G, Wong, KK, Letai, AG & Chonghaile, TN 2021, 'Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer', Science Advances, vol. 7, no. 3, eabc4897.
Tran, TNA, Wikle, NB, Albert, E, Inam, H, Strong, E, Brinda, K, Leighow, SM, Yang, F, Hossain, S, Pritchard, JR, Chan, P, Hanage, WP, Hanks, EM & Boni, MF 2021, 'Optimal SARS-CoV-2 vaccine allocation using real-time attack-rate estimates in Rhode Island and Massachusetts', BMC Medicine, vol. 19, no. 1, 162.
Hullahalli, K, Pritchard, JR & Waldor, MK 2021, 'Refined quantification of infection bottlenecks and pathogen dissemination with STAMPR', mSystems, vol. 6, no. 4, e00887-21.
Marloye, M, Inam, H, Moore, CJ, Debaille, V, Pritchard, JR, Gelbcke, M, Meyer, F, Dufrasne, F & Berger, G 2021, 'Synthesis, structure and anticancer properties of new biotin- and morpholine-functionalized ruthenium and osmium half-sandwich complexes', Journal of Biological Inorganic Chemistry, vol. 26, no. 5, pp. 535-549.


Leighow, SM, Liu, C, Inam, H, Zhao, B & Pritchard, JR 2020, 'Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design', Cell Reports, vol. 30, no. 12, pp. 3951-3963.e4.
Bruno, PM, Lu, M, Dennis, KA, Inam, H, Moore, CJ, Sheehe, J, Elledge, SJ, Hemann, MT & Pritchard, JR 2020, 'The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 8, pp. 4053-4060.
Short, NJ, Kantarjian, H, Kanagal-Shamanna, R, Sasaki, K, Ravandi, F, Cortes, J, Konopleva, M, Issa, GC, Kornblau, SM, Garcia-Manero, G, Garris, R, Higgins, J, Pratt, G, Williams, LN, Valentine, CC, Rivera, VM, Pritchard, J, Salk, JJ, Radich, J & Jabbour, E 2020, 'Ultra-accurate Duplex Sequencing for the assessment of pretreatment ABL1 kinase domain mutations in Ph+ ALL', Blood Cancer Journal, vol. 10, no. 5, 61.