Researcher Profile

Researcher Profile

Justin Pritchard

Justin Pritchard

Assistant Professor, Biomedical Engineering
Center for Infectious Disease Dynamics
Scientific Program:Mechanisms of Carcinogenesis
jrp94@psu.edu

Research Interests

  • Neoplasms
  • Therapeutics
  • Pharmaceutical Preparations
  • Mutation
  • Growth
  • Genes
  • Genome
  • Drug Resistance
  • SARS Virus
  • Infections
  • Population
  • Leukemia

Recent Publications

2022

Zhao, B, Rao, Y, Leighow, S, O’Brien, EP, Gilbert, L & Pritchard, JR 2022, 'A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments', Nature communications, vol. 13, no. 1, 625. https://doi.org/10.1038/s41467-022-28045-w
Pritchard, JR, Lee, MJ & Peyton, SR 2022, 'Materials-driven approaches to understand extrinsic drug resistance in cancer', Soft matter. https://doi.org/10.1039/d2sm00071g
George, S, von Mehren, M, Fletcher, JA, Sun, J, Zhang, S, Pritchard, JR, Hodgson, JG, Kerstein, D, Rivera, VM, Haluska, FG & Heinrich, MC 2022, 'Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers', Clinical Cancer Research, vol. 28, no. 7, pp. 1268-1276. https://doi.org/10.1158/1078-0432.CCR-21-2037
Tran, TNA, Wikle, NB, Yang, F, Inam, H, Leighow, S, Gentilesco, B, Chan, P, Albert, E, Strong, ER, Pritchard, J, Hanage, WP, Hanks, EM, Crawford, FW & Boni, MF 2022, 'SARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 2021', JAMA network open, vol. 5, no. 5, pp. E2214171. https://doi.org/10.1001/jamanetworkopen.2022.14171
Wikle, NB, Nguyen-Anh Tran, T, Gentilesco, B, Leighow, SM, Albert, E, Strong, ER, Brinda, K, Inam, H, Yang, F, Hossain, S, Chan, P, Hanage, WP, Messick, M, Pritchard, JR, Hanks, EM & Boni, MF 2022, 'SARS-CoV-2 epidemic after social and economic reopening in three U.S. states reveals shifts in age structure and clinical characteristics', Science Advances, vol. 8, no. 4, eabf9868. https://doi.org/10.1126/sciadv.abf9868
Marloye, M, Inam, H, Moore, CJ, Mertens, TR, Ingels, A, Koch, M, Nowicki, MO, Mathieu, V, Pritchard, JR, Awuah, SG, Lawler, SE, Meyer, F, Dufrasne, F & Berger, G 2022, 'Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity', Inorganic Chemistry Frontiers. https://doi.org/10.1039/d2qi00423b

2021

Yogodzinski, C, Arab, A, Pritchard, JR, Goodarzi, H & Gilbert, LA 2021, 'A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy', Genome Medicine, vol. 13, no. 1, 167. https://doi.org/10.1186/s13073-021-00987-8
Inam, H, Sokirniy, I, Rao, Y, Shah, A, Naeemikia, F, O'Brien, E, Dong, C, McCandlish, DM & Pritchard, JR 2021, 'Genomic and experimental evidence that ALKATI does not predict single agent sensitivity to ALK inhibitors', iScience, vol. 24, no. 11, 103343. https://doi.org/10.1016/j.isci.2021.103343
Dowling, CM, Hollinshead, KER, Di Grande, A, Pritchard, J, Zhang, H, Dillon, ET, Haley, K, Papadopoulos, E, Mehta, AK, Bleach, R, Lindner, AU, Mooney, B, Düssmann, H, O'Connor, D, Prehn, JHM, Wynne, K, Hemann, M, Bradner, JE, Kimmelman, AC, Guerriero, JL, Cagney, G, Wong, KK, Letai, AG & Chonghaile, TN 2021, 'Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer', Science Advances, vol. 7, no. 3, eabc4897. https://doi.org/10.1126/sciadv.abc4897
Tran, TNA, Wikle, NB, Albert, E, Inam, H, Strong, E, Brinda, K, Leighow, SM, Yang, F, Hossain, S, Pritchard, JR, Chan, P, Hanage, WP, Hanks, EM & Boni, MF 2021, 'Optimal SARS-CoV-2 vaccine allocation using real-time attack-rate estimates in Rhode Island and Massachusetts', BMC Medicine, vol. 19, no. 1, 162. https://doi.org/10.1186/s12916-021-02038-w
Hullahalli, K, Pritchard, JR & Waldor, MK 2021, 'Refined quantification of infection bottlenecks and pathogen dissemination with STAMPR', mSystems, vol. 6, no. 4, e00887-21. https://doi.org/10.1128/mSystems.00887-21
Marloye, M, Inam, H, Moore, CJ, Debaille, V, Pritchard, JR, Gelbcke, M, Meyer, F, Dufrasne, F & Berger, G 2021, 'Synthesis, structure and anticancer properties of new biotin- and morpholine-functionalized ruthenium and osmium half-sandwich complexes', Journal of Biological Inorganic Chemistry, vol. 26, no. 5, pp. 535-549. https://doi.org/10.1007/s00775-021-01873-9

2020

Leighow, SM, Liu, C, Inam, H, Zhao, B & Pritchard, JR 2020, 'Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design', Cell Reports, vol. 30, no. 12, pp. 3951-3963.e4. https://doi.org/10.1016/j.celrep.2020.02.108
Bruno, PM, Lu, M, Dennis, KA, Inam, H, Moore, CJ, Sheehe, J, Elledge, SJ, Hemann, MT & Pritchard, JR 2020, 'The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 8, pp. 4053-4060. https://doi.org/10.1073/pnas.1921649117
Short, NJ, Kantarjian, H, Kanagal-Shamanna, R, Sasaki, K, Ravandi, F, Cortes, J, Konopleva, M, Issa, GC, Kornblau, SM, Garcia-Manero, G, Garris, R, Higgins, J, Pratt, G, Williams, LN, Valentine, CC, Rivera, VM, Pritchard, J, Salk, JJ, Radich, J & Jabbour, E 2020, 'Ultra-accurate Duplex Sequencing for the assessment of pretreatment ABL1 kinase domain mutations in Ph+ ALL', Blood Cancer Journal, vol. 10, no. 5, 61. https://doi.org/10.1038/s41408-020-0329-y

2019

Zhao, B & Pritchard, JR 2019, 'Evolution of the nonsense-mediated decay pathway is associated with decreased cytolytic immune infiltration', PLoS computational biology, vol. 15, no. 10, e1007467. https://doi.org/10.1371/journal.pcbi.1007467

2018

Laencina, L, Dubois, V, Le Moigne, V, Viljoen, A, Majlessi, L, Pritchard, J, Bernut, A, Piel, L, Roux, AL, Gaillard, JL, Lombard, B, Loew, D, Rubin, EJ, Brosch, R, Kremer, L, Herrmann, JL & Girard-Misguich, F 2018, 'Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 5, pp. E1002-E1011. https://doi.org/10.1073/pnas.1713195115
Gozgit, JM, Chen, TH, Song, Y, Wardwell, S, Wang, F, Cai, J, Li, H, Edgren, H, Rivera, VM & Pritchard, J 2018, 'RET fusions observed in lung and colorectal cancers are sensitive to ponatinib', Oncotarget, vol. 9, no. 51, pp. 29654-29664. https://doi.org/10.18632/oncotarget.25664
Schmitt, MW, Pritchard, JR, Leighow, SM, Aminov, BI, Beppu, L, Kim, DS, Hodgson, JG, Rivera, VM, Loeb, LA & Radich, JP 2018, 'Single-molecule sequencing reveals patterns of preexisting drug resistance that suggest treatment strategies in Philadelphia-positive leukemias', Clinical Cancer Research, vol. 24, no. 21, pp. 5321-5334. https://doi.org/10.1158/1078-0432.CCR-18-0167

Clinical Trials Search


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