Justin Pritchard - Penn State Cancer Institute
Researcher Profile
Justin Pritchard
Associate Professor, Biomedical Engineering
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2025
Sokirniy, I, Inam, H, Tomaszkiewicz, M, Reynolds, J, McCandlish, D & Pritchard, J 2025, 'A side-by-side comparison of variant function measurements using deep mutational scanning and base editing', Nucleic acids research, vol. 53, no. 14, gkaf738. https://doi.org/10.1093/nar/gkaf738
Komarova, NL, Pritchard, JR & Wodarz, D 2025, 'Efficient mathematical methodology to determine multistep mutant burden in spatially growing cell populations', PNAS Nexus, vol. 4, no. 9, pgaf271. https://doi.org/10.1093/pnasnexus/pgaf271
Hossain, SM, Rao, Y, Hossain, JO, Pritchard, JR & Zhao, B 2025, 'goloco: a web application to create genome scale information from surprisingly small experiments', BMC bioinformatics, vol. 26, no. 1, 61. https://doi.org/10.1186/s12859-025-06070-y
2024
Leighow, SM, Reynolds, JA, Sokirniy, I, Yao, S, Yang, Z, Inam, H, Wodarz, D, Archetti, M & Pritchard, J 2025, 'Programming tumor evolution with selection gene drives to proactively combat drug resistance', Nature Biotechnology, vol. 43, no. 5, 940, pp. 737-751. https://doi.org/10.1038/s41587-024-02271-7
2023
Reynolds, JA, Vishweshwaraiah, YL, Chirasani, VR, Pritchard, JR & Dokholyan, NV 2023, 'An engineered N-acyltransferase-LOV2 domain fusion protein enables light-inducible allosteric control of enzymatic activity', Journal of Biological Chemistry, vol. 299, no. 4, 103069. https://doi.org/10.1016/j.jbc.2023.103069
Lawanprasert, A, Sloand, JN, González Vargas, M, Singh, H, Eldor, T, Miller, MA, Pimcharoen, S, Wang, J, Leighow, SM, Pritchard, JR, Dokholyan, NV & Medina, SH 2023, 'Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions', ChemBioChem, vol. 24, no. 13, e202300159. https://doi.org/10.1002/cbic.202300159
Liu, C, Leighow, SM, McIlroy, K, Lu, M, Dennis, KA, Abello, K, Brown, DJ, Moore, CJ, Shah, A, Inam, H, Rivera, VM & Pritchard, JR 2023, 'Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing', Cell Reports Medicine, vol. 4, no. 10, 101227. https://doi.org/10.1016/j.xcrm.2023.101227
Halder, R, Nissley, DA, Sitarik, I, Jiang, Y, Rao, Y, Vu, QV, Li, MS, Pritchard, J & O’Brien, EP 2023, 'How soluble misfolded proteins bypass chaperones at the molecular level', Nature communications, vol. 14, no. 1, 3689. https://doi.org/10.1038/s41467-023-38962-z
Rao, Y, Ahmed, N, Pritchard, J & O’Brien, EP 2023, 'Incorporating mutational heterogeneity to identify genes that are enriched for synonymous mutations in cancer', BMC bioinformatics, vol. 24, no. 1, 462. https://doi.org/10.1186/s12859-023-05521-8
Yeware, A, Helton, A, Dong, Y, Dong, C, Pritchard, J, Mineishi, S, Minagawa, K, Schell, T & Hayes, D 2023, 'Novel fourth generation-like CARmiR cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity', Biochemical Engineering Journal, vol. 199, 109068. https://doi.org/10.1016/j.bej.2023.109068
Kreger, J, Brown, D, Komarova, NL, Wodarz, D & Pritchard, J 2023, 'The role of migration in mutant dynamics in fragmented populations', Journal of Evolutionary Biology, vol. 36, no. 2, pp. 444-460. https://doi.org/10.1111/jeb.14131
2022
Zhao, B, Rao, Y, Leighow, S, O’Brien, EP, Gilbert, L & Pritchard, JR 2022, 'A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments', Nature communications, vol. 13, no. 1, 625. https://doi.org/10.1038/s41467-022-28045-w
Leighow, SM, Landry, B, Lee, MJ, Peyton, SR & Pritchard, JR 2022, 'Agent-Based Models Help Interpret Patterns of Clinical Drug Resistance by Contextualizing Competition Between Distinct Drug Failure Modes', Cellular and Molecular Bioengineering, vol. 15, no. 5, pp. 521-533. https://doi.org/10.1007/s12195-022-00748-6
Pritchard, JR, Lee, MJ & Peyton, SR 2022, 'Materials-driven approaches to understand extrinsic drug resistance in cancer', Soft matter, vol. 18, no. 18, pp. 3465-3472. https://doi.org/10.1039/d2sm00071g
George, S, von Mehren, M, Fletcher, JA, Sun, J, Zhang, S, Pritchard, JR, Hodgson, JG, Kerstein, D, Rivera, VM, Haluska, FG & Heinrich, MC 2022, 'Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers', Clinical Cancer Research, vol. 28, no. 7, pp. 1268-1276. https://doi.org/10.1158/1078-0432.CCR-21-2037
Tran, TNA, Wikle, NB, Yang, F, Inam, H, Leighow, S, Gentilesco, B, Chan, P, Albert, E, Strong, ER, Pritchard, JR, Hanage, WP, Hanks, EM, Crawford, FW & Boni, MF 2022, 'SARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 2021', JAMA network open, vol. 5, no. 5, pp. E2214171. https://doi.org/10.1001/jamanetworkopen.2022.14171
Wikle, NB, Nguyen-Anh Tran, T, Gentilesco, B, Leighow, SM, Albert, E, Strong, ER, Brinda, K, Inam, H, Yang, F, Hossain, S, Chan, P, Hanage, WP, Messick, M, Pritchard, JR, Hanks, EM & Boni, MF 2022, 'SARS-CoV-2 epidemic after social and economic reopening in three U.S. states reveals shifts in age structure and clinical characteristics', Science Advances, vol. 8, no. 4, eabf9868. https://doi.org/10.1126/sciadv.abf9868
Marloye, M, Inam, H, Moore, CJ, Mertens, TR, Ingels, A, Koch, M, Nowicki, MO, Mathieu, V, Pritchard, JR, Awuah, SG, Lawler, SE, Meyer, F, Dufrasne, F & Berger, G 2022, 'Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity', Inorganic Chemistry Frontiers, vol. 9, no. 11, pp. 2594-2607. https://doi.org/10.1039/d2qi00423b
Hospodiuk-Karwowski, M, Chi, K, Pritchard, J & Catchmark, JM 2022, 'Vascularized pancreas-on-a-chip device produced using a printable simulated extracellular matrix', Biomedical Materials (Bristol), vol. 17, no. 6, 065006. https://doi.org/10.1088/1748-605X/ac8c74