Researcher Profile

Researcher Profile

Justin Pritchard

Justin Pritchard

Assistant Professor, Biomedical Engineering
Scientific Program:Mechanisms of Carcinogenesis
jrp94@psu.edu

Research Interests

  • Neoplasms
  • Therapeutics
  • Pharmaceutical Preparations
  • Growth
  • Mutation
  • Genes
  • Genome
  • Leukemia
  • Drug Resistance
  • Drug Combinations
  • Small Interfering RNA
  • Cell Death

Recent Publications

2020

Bruno, PM, Lu, M, Dennis, KA, Inam, H, Moore, CJ, Sheehe, J, Elledge, SJ, Hemann, MT & Pritchard, JR 2020, 'The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 8, pp. 4053-4060. https://doi.org/10.1073/pnas.1921649117

2019

Zhao, B & Pritchard, JR 2019, 'Evolution of the nonsense-mediated decay pathway is associated with decreased cytolytic immune infiltration', PLoS computational biology, vol. 15, no. 10, e1007467. https://doi.org/10.1371/journal.pcbi.1007467

2018

Laencina, L, Dubois, V, Le Moigne, V, Viljoen, A, Majlessi, L, Pritchard, J, Bernut, A, Piel, L, Roux, AL, Gaillard, JL, Lombard, B, Loew, D, Rubin, EJ, Brosch, R, Kremer, L, Herrmann, JL & Girard-Misguich, F 2018, 'Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 5, pp. E1002-E1011. https://doi.org/10.1073/pnas.1713195115
Gozgit, JM, Chen, TH, Song, Y, Wardwell, S, Wang, F, Cai, J, Li, H, Edgren, H, Rivera, VM & Pritchard, J 2018, 'RET fusions observed in lung and colorectal cancers are sensitive to ponatinib', Oncotarget, vol. 9, no. 51, pp. 29654-29664. https://doi.org/10.18632/oncotarget.25664
Schmitt, MW, Pritchard, JR, Leighow, SM, Aminov, BI, Beppu, L, Kim, DS, Hodgson, JG, Rivera, VM, Loeb, LA & Radich, JP 2018, 'Single-molecule sequencing reveals patterns of preexisting drug resistance that suggest treatment strategies in Philadelphia-positive leukemias', Clinical Cancer Research, vol. 24, no. 21, pp. 5321-5334. https://doi.org/10.1158/1078-0432.CCR-18-0167

2017

Bruno, PM, Liu, Y, Park, GY, Murai, J, Koch, CE, Eisen, TJ, Pritchard, JR, Pommier, Y, Lippard, SJ & Hemann, MT 2017, 'A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress', Nature Medicine, vol. 23, no. 4, pp. 461-471. https://doi.org/10.1038/nm.4291
Rock, JM, Hopkins, FF, Chavez, A, Diallo, M, Chase, MR, Gerrick, ER, Pritchard, JR, Church, GM, Rubin, EJ, Sassetti, CM, Schnappinger, D & Fortune, SM 2017, 'Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform', Nature Microbiology, vol. 2, 16274. https://doi.org/10.1038/nmicrobiol.2016.274

2016

Zhao, B, Sedlak, JC, Srinivas, R, Creixell, P, Pritchard, JR, Tidor, B, Lauffenburger, DA & Hemann, MT 2016, 'Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution', Cell, vol. 165, no. 1, pp. 234-246. https://doi.org/10.1016/j.cell.2016.01.045
Zhao, B & Pritchard, JR 2016, 'Inherited Disease Genetics Improves the Identification of Cancer-Associated Genes', PLoS genetics, vol. 12, no. 6, e1006081. https://doi.org/10.1371/journal.pgen.1006081

Clinical Trials Search


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