Researcher Profile

Researcher Profile

Chan Shen, PhD

Chan Shen, PhD

Associate Professor, Department of Surgery
Chief, Division of Outcomes, Research and Quality
Scientific Program:Cancer Control
czs5992@psu.edu

Research Interests

  • Therapeutics
  • Neoplasms
  • Elderly
  • Medicare
  • Survival
  • Neuroendocrine Tumors
  • Breast Neoplasms
  • Delivery of Health Care
  • Health Expenditures
  • Costs and Cost Analysis
  • Depression
  • Population

Recent Publications

2022

Arhin, N, Ssentongo, P, Taylor, M, Olecki, EJ, Pameijer, C, Shen, C, Oh, J & Eng, C 2022, 'Age-standardised incidence rate and epidemiology of colorectal cancer in Africa: A systematic review and meta-analysis', BMJ open, vol. 12, no. 1, e052376. https://doi.org/10.1136/bmjopen-2021-052376
Stahl, KA, Dodge, D, Olecki, EJ, Holguin, RP, McLaughlin, C, Wong, W & Shen, C 2022, 'Insurance Status and Travel Distance to Single Treatment Facility Predictive of Mastectomy', Journal of Surgical Research, vol. 270, pp. 22-30. https://doi.org/10.1016/j.jss.2021.08.035
Wong, W, Perez Holguin, RA, Olecki, EJ, Stahl, KA, Dixon, M, Peng, J, Dasari, A & Shen, C 2022, 'Predictors and Outcomes of Minimally Invasive Surgery for Small Bowel Neuroendocrine Tumors: Minimally Invasive Surgery for SBNETs', Journal of Gastrointestinal Surgery. https://doi.org/10.1007/s11605-022-05264-6
Lapelusa, M, Shen, C, Arhin, ND, Cardin, D, Tan, M, Idrees, K, Geevarghese, S, Chakravarthy, B, Berlin, J & Eng, C 2022, 'Trends in the Incidence and Treatment of Early-Onset Pancreatic Cancer', Cancers, vol. 14, no. 2, 283. https://doi.org/10.3390/cancers14020283
Shen, C, Holguin, RAP, Schaefer, E, Zhou, S, Belani, CP, Ma, PC & Reed, MF 2022, 'Utilization and costs of epidermal growth factor receptor mutation testing and targeted therapy in Medicare patients with metastatic lung adenocarcinoma', BMC health services research, vol. 22, no. 1, 470. https://doi.org/10.1186/s12913-022-07857-y

2021

Stahl, K, Dodge, D, Wong, W & Shen, C 2022, 'ASO Author Reflection: Trimodality Therapy Offers Survival Advantage in Metastatic Male Breast Cancer', Annals of Surgical Oncology, vol. 29, no. 2, pp. 1018. https://doi.org/10.1245/s10434-021-10790-9
Olecki, EJ, Stahl, KA, Torres, MB, Peng, JS, Dixon, M, Shen, C & Gusani, NJ 2021, 'ASO Visual Abstract: Adjuvant Chemotherapy After Neoadjuvant Chemotherapy for Pancreatic Cancer is Associated with Improved Survival in Those with Low-Risk Pathology', Annals of Surgical Oncology, vol. 28, no. 6, pp. 3124. https://doi.org/10.1245/s10434-021-09764-8
Wiener, RC, Findley, PA, Shen, C, Dwibedi, N & Sambamoorthi, U 2021, 'Acculturation and dental sealant use among US children', Community Dentistry and Oral Epidemiology. https://doi.org/10.1111/cdoe.12678
Olecki, EJ, Stahl, KA, Torres, MB, Peng, JS, Dixon, M, Shen, C & Gusani, NJ 2021, 'Adjuvant Chemotherapy After Neoadjuvant Chemotherapy for Pancreatic Cancer is Associated with Improved Survival for Patients with Low-Risk Pathology', Annals of Surgical Oncology, vol. 28, no. 6, pp. 3111-3122. https://doi.org/10.1245/s10434-020-09546-8
Klein, R & Shen, C 2021, 'An IV estimator for a functional coefficient model with endogenous discrete treatments', Econometric Reviews, vol. 40, no. 6, pp. 540-561. https://doi.org/10.1080/07474938.2021.1889200
Shen, C, Klein, RW, Moss, JL, Dodge, DG, Chetlen, AL, Stahl, KA, Zhou, S, Leslie, DL, Ruffin, MT & Lengerich, EJ 2021, 'Association Between Dense Breast Legislation and Cancer Stage at Diagnosis', American Journal of Preventive Medicine, vol. 61, no. 6, pp. 890-899. https://doi.org/10.1016/j.amepre.2021.05.020
Stahl, KA, Wong, W, Olecki, EJ, McLaughlin, C, Perez-Holguin, R, Lewcun, JA, Dodge, D & Shen, C 2022, 'Benefits of Trimodality Therapy Compared with Systemic Therapy Alone in Male Patients with Stage IV Breast Cancer', Annals of Surgical Oncology, vol. 29, no. 2, pp. 1005-1017. https://doi.org/10.1245/s10434-021-10729-0
Findley, PA, Wiener, RC, Shen, C, Dwibedi, N & Sambamoorthi, U 2021, 'Clinical Preventive Services and Self-Management Practices Among Adult Cancer Survivors in the United States Over Time', Cancer Control, vol. 28. https://doi.org/10.1177/10732748211059106
Wiener, RC, Findley, PA & Shen, C 2021, Dental and Oral Health. in Handbook of Rural Aging. Taylor and Francis, pp. 95-99.
Rai, P, Shen, C, Kolodney, J, Kelly, KM, Scott, VG & Sambamoorthi, U 2021, 'Factors associated with immune checkpoint inhibitor use among older adults with late-stage melanoma: A population-based study', Medicine, vol. 100, no. 7, pp. e24782. https://doi.org/10.1097/MD.0000000000024782
Stahl, KA, Olecki, EJ, Dixon, ME, Peng, JS, Torres, MB, Gusani, NJ & Shen, C 2021, 'Gastric cancer treatments and survival trends in the United States', Current Oncology, vol. 28, no. 1, pp. 138-151. https://doi.org/10.3390/curroncol28010017
Lewcun, J, Massand, S, Trangucci, J, Shen, C & Johnson, TS 2021, 'Head and Neck Free Flap Reconstruction in an Academic versus a Community Setting', Journal of Reconstructive Microsurgery. https://doi.org/10.1055/s-0041-1735835
Rai, P, Shen, C, Kolodney, J, Kelly, KM, Scott, VG & Sambamoorthi, U 2021, 'Immune checkpoint inhibitor use, multimorbidity and healthcare expenditures among older adults with late-stage melanoma', Immunotherapy, vol. 13, no. 2, pp. 103-112. https://doi.org/10.2217/imt-2020-0152
Iloabuchi, C, Dwibedi, N, LeMasters, T, Shen, C, Ladani, A & Sambamoorthi, U 2021, 'Low-value care and excess out-of-pocket expenditure among older adults with incident cancer – A machine learning approach', Journal of Cancer Policy, vol. 30, 100312. https://doi.org/10.1016/j.jcpo.2021.100312
Olecki, EJ, Stahl, KA, Torres, MB, Peng, JS, Shen, C, Dixon, MEB & Gusani, NJ 2021, 'Pathologic upstaging in resected pancreatic adenocarcinoma: Risk factors and impact on survival', Journal of Surgical Oncology, vol. 124, no. 1, pp. 79-87. https://doi.org/10.1002/jso.26481
Constance Wiener, R, Findley, PA, Shen, C, Dwibedi, N & Sambamoorthi, U 2021, 'Relationship between smoking status and muscle strength in the United States older adults', Epidemiology and health, vol. 42, e2020055. https://doi.org/10.4178/epih.e2020055
Stahl, K, Dodge, D & Shen, C 2021, 'Surgery of the Primary Tumor in De Novo Metastatic Breast Cancer Confers No Survival Benefit: Author’s Reply', Annals of Surgical Oncology, vol. 28, pp. 789-790. https://doi.org/10.1245/s10434-021-10906-1
Arhin, ND, Shen, C, Bailey, CE, Matsuoka, LK, Hawkins, AT, Holowatyj, AN, Ciombor, KK, Hopkins, MB, Geiger, TM, Kam, AE, Roth, MT, Lebeck Lee, CM, Lapelusa, M, Dasari, A & Eng, C 2021, 'Surgical resection and survival outcomes in metastatic young adult colorectal cancer patients', Cancer medicine, vol. 10, no. 13, pp. 4269-4281. https://doi.org/10.1002/cam4.3940
Wong, WG, Stahl, K, Olecki, EJ, Holguin, RP, Pameijer, C & Shen, C 2021, 'Survival Benefit of Guideline-Concordant Postoperative Radiation for Local Merkel Cell Carcinoma', Journal of Surgical Research, vol. 266, pp. 168-179. https://doi.org/10.1016/j.jss.2021.03.062

2020

Olecki, E, Gusani, N & Shen, C 2021, 'ASO Author Reflections: Undertreatment of Pancreatic Cancer After Resection: Don’t Get Fooled by Favorable Final Pathology', Annals of Surgical Oncology, vol. 28, no. 3, pp. 1593-1594. https://doi.org/10.1245/s10434-020-09079-0
Gu, D, Morgan, RO, Li, R, Weber, ES & Shen, C 2020, 'Association between depression and healthcare expenditures among elderly cancer patients', BMC psychiatry, vol. 20, no. 1, 131. https://doi.org/10.1186/s12888-020-02527-x
Fiano, RM, Merrick, GS, Innes, KE, Mattes, MD, LeMasters, TJ, Shen, C & Sambamoorthi, U 2020, 'Associations of multimorbidity and patient-reported experiences of care with conservative management among elderly patients with localized prostate cancer', Cancer medicine, vol. 9, no. 16, pp. 6051-6061. https://doi.org/10.1002/cam4.3274
Stahl, K, Wong, W, Dodge, D, Brooks, A, McLaughlin, C, Olecki, E, Lewcun, J, Newport, K, Vasekar, M & Shen, C 2021, 'Benefits of Surgical Treatment of Stage IV Breast Cancer for Patients With Known Hormone Receptor and HER2 Status', Annals of Surgical Oncology, vol. 28, no. 5, pp. 2646-2658. https://doi.org/10.1245/s10434-020-09244-5
Varisco, T, Shen, C & Thornton, D 2020, 'Chronic prescription opioid use predicts stabilization on buprenorphine for the treatment of opioid use disorder', Journal of Substance Abuse Treatment, vol. 117, 108073. https://doi.org/10.1016/j.jsat.2020.108073
Parham, CS, Shen, C, Pennock, MM, Henderson, SR, Kulaylat, AS & Johnson, TS 2020, 'Correlation between venous thromboembolism risk and venous congestion in microvascular reconstruction of the lower extremity', Plastic and reconstructive surgery, pp. 1177-1185. https://doi.org/10.1097/PRS.0000000000007273
Gu, D & Shen, C 2020, 'Cost-Related Medication Nonadherence and Cost-Reduction Strategies among Elderly Cancer Survivors with Self-Reported Symptoms of Depression', Population Health Management, vol. 23, no. 2, pp. 132-139. https://doi.org/10.1089/pop.2019.0035
Roy, S, Moss, JL, Rodriguez-Colon, SM, Shen, C, Cooper, JD, Lennon, RP, Lengerich, EJ, Adelman, A, Curry, W & Ruffin, MT 2020, 'Examining Older Adults’ Attitudes and Perceptions of Cancer Screening and Overscreening: A Qualitative Study', Journal of Primary Care and Community Health, vol. 11. https://doi.org/10.1177/2150132720959234
Shen, C, Gu, D, Klein, R, Zhou, S, Shih, YCT, Tracy, T, Soybel, D & Dillon, P 2020, 'Factors Associated With Hospital Decisions to Purchase Robotic Surgical Systems', MDM Policy and Practice, vol. 5, no. 1. https://doi.org/10.1177/2381468320904364
Moss, JL, Roy, S, Shen, C, Cooper, JD, Lennon, RP, Lengerich, EJ, Adelman, A, Curry, W & Ruffin, MT 2020, 'Geographic Variation in Overscreening for Colorectal, Cervical, and Breast Cancer Among Older Adults', JAMA network open, vol. 3, no. 7, pp. e2011645. https://doi.org/10.1001/jamanetworkopen.2020.11645
Wiener, RC, Findley, PA, Shen, C, Dwibedi, N & Sambamoorthi, U 2020, 'Human papillomavirus (HPV) vaccine utilization among adults (18–29 years), BRFSS 2015', Vaccine, vol. 38, no. 33, pp. 5119-5122. https://doi.org/10.1016/j.vaccine.2020.05.056
Downs, CG, Varisco, TJ, Bapat, SS, Shen, C & Thornton, JD 2021, 'Impact of COVID-19 related policy changes on filling of opioid and benzodiazepine medications', Research in Social and Administrative Pharmacy, vol. 17, no. 1, pp. 2005-2008. https://doi.org/10.1016/j.sapharm.2020.06.003
Rai, P, Shen, C, Kolodney, J, Kelly, KM, Scott, VG & Sambamoorthi, U 2021, 'Prevalence and risk factors for multimorbidity in older US patients with late-stage melanoma', Journal of Geriatric Oncology, vol. 12, no. 3, pp. 388-393. https://doi.org/10.1016/j.jgo.2020.09.019
Shen, C, Thornton, JD, Gu, D, Dodge, D, Zhou, S, He, W, Zhao, H & Giordano, SH 2020, 'Prolonged Opioid Use After Surgery for Early-Stage Breast Cancer', Oncologist, vol. 25, no. 10, pp. e1574-e1582. https://doi.org/10.1634/theoncologist.2019-0868
Abudayyeh, A, Song, J, Abdelrahim, M, Dahbour, I, Page, VD, Zhou, S, Shen, C, Zhao, B, Pai, RN, Amaram-Davila, J, Manzano, JG, George, MC, Yennu, S, Mandayam, SA, Nates, JL & Moss, AH 2020, 'Renal Replacement Therapy in Patients With Stage IV Cancer Admitted to the Intensive Care Unit With Acute Kidney Injury at a Comprehensive Cancer Center Was Not Associated With Survival', American Journal of Hospice and Palliative Medicine, vol. 37, no. 9, pp. 707-715. https://doi.org/10.1177/1049909120902115
Shen, C, Thornton, JD, Newport, K, Schaefer, E, Zhou, S, Yee, NS, Dodge, D & Leslie, D 2020, 'Trends and patterns in the use of opioids among metastatic breast cancer patients', Scientific reports, vol. 10, no. 1, 21698. https://doi.org/10.1038/s41598-020-78569-8
Olecki, EJ, Stahl, K, Peng, JS, Dixon, M, Gusani, NJ & Shen, C 2021, 'Undertreatment of Pancreatic Cancer: Role of Surgical Pathology', Annals of Surgical Oncology, vol. 28, no. 3, pp. 1581-1592. https://doi.org/10.1245/s10434-020-09043-y

2019

Gu, D & Shen, C 2019, 'Assessing the Importance of Factors Associated with Cost-Related Nonadherence to Medication for Older US Medicare Beneficiaries', Drugs and Aging, vol. 36, no. 12, pp. 1111-1121. https://doi.org/10.1007/s40266-019-00715-3
Dwibedi, N, Wiener, RC, Findley, PA, Shen, C & Sambamoorthi, U 2020, 'Asthma, chronic obstructive pulmonary disease, tooth loss, and edentulism among adults in the United States: 2016 Behavioral Risk Factor Surveillance System survey', Journal of the American Dental Association, vol. 151, no. 10, pp. 735-744.e1. https://doi.org/10.1016/j.adaj.2019.07.032
Shen, C, Dasari, A, Chu, Y, Halperin, DM, Zhou, S, Xu, Y, Shih, YT & Yao, JC 2019, 'Erratum: Clinical, pathological, and demographic factors associated with development of recurrences after surgical resection in elderly patients with neuroendocrine tumors (Annals of Oncology (2017) 28(7) (1582–1589), (S0923753419322616), (10.1093/annonc/mdx164))', Annals of Oncology, vol. 30, no. 11, pp. 1847. https://doi.org/10.1093/annonc/mdz220
Findley, PA, Wiener, RC, Shen, C, Dwibedi, N & Sambamoorthi, U 2019, 'Health reform under the patient protection and Affordable Care Act: characteristics of exchange-based health insurance enrollees', Social Work in Health Care, vol. 58, no. 7, pp. 685-702. https://doi.org/10.1080/00981389.2019.1619116
Fried, DA, Sadeghi-Nejad, H, Gu, D, Zhou, S, He, W, Giordano, SH, Pentakota, SR, Demissie, K, Helmer, D & Shen, C 2019, 'Impact of serious mental illness on the treatment and mortality of older patients with locoregional high-grade (nonmetastatic) prostate cancer: retrospective cohort analysis of 49 985 SEER-Medicare patients diagnosed between 2006 and 2013', Cancer medicine, vol. 8, no. 5, pp. 2612-2622. https://doi.org/10.1002/cam4.2109
Shen, C, Gu, D, Zhou, S, Xu, Y, Sarshekeh, AM, Halperin, D, Shih, YCT, Yao, JC & Dasari, A 2019, 'Racial Differences in the Incidence and Survival of Patients with Neuroendocrine Tumors', Pancreas, vol. 48, no. 10, pp. 1373-1379. https://doi.org/10.1097/MPA.0000000000001431
Wang, Y, Zhou, S, Yang, F, Qi, X, Wang, X, Guan, X, Shen, C, Duma, N, Vera Aguilera, J, Chintakuntlawar, A, Price, KA, Molina, JR, Pagliaro, LC, Halfdanarson, TR, Grothey, A, Markovic, SN, Nowakowski, GS, Ansell, SM & Wang, ML 2019, 'Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis', JAMA Oncology, vol. 5, no. 7, pp. 1008-1019. https://doi.org/10.1001/jamaoncol.2019.0393

2018

Shen, C, Zhao, B, Liu, L & Shih, YCT 2018, 'Adherence to tyrosine kinase inhibitors among Medicare Part D beneficiaries with chronic myeloid leukemia', Cancer, vol. 124, no. 2, pp. 364-373. https://doi.org/10.1002/cncr.31050
Dwibedi, N, Findley, PA, Wiener, CR, Shen, C & Sambamoorthi, U 2018, 'Alzheimer Disease and Related Disorders and Out-of-Pocket Health Care Spending and Burden among Elderly Medicare Beneficiaries', Medical care, vol. 56, no. 3, pp. 240-246. https://doi.org/10.1097/MLR.0000000000000869
Shen, C, Dasari, A, Gu, D, Chu, Y, Zhou, S, Xu, Y, Halperin, D, Fu, S, Yao, JC & Shih, YCT 2018, 'Costs of Cancer Care for Elderly Patients with Neuroendocrine Tumors', PharmacoEconomics, vol. 36, no. 8, pp. 1005-1013. https://doi.org/10.1007/s40273-018-0656-z
Wiener, RC, Shen, C, Findley, P, Tan, X & Sambamoorthi, U 2018, 'Dental Fluorosis over Time: A comparison of National Health and Nutrition Examination Survey data from 2001-2002 and 2011-2012', Journal of dental hygiene : JDH, vol. 92, no. 1, pp. 23-29.
Wiener, RC, Shen, C, Findley, PA, Dwibedi, N & Sambamoorthi, U 2018, 'Depressive symptoms and untreated coronal dental caries among adults ages 21-64 years, NHANES 2013-2014', Community dental health, vol. 35, no. 3, pp. 179-185. https://doi.org/10.1922/CDH_4304Weiner07
Wiener, RC, Sambamoorthi, U, Shen, C, Alwhaibi, M & Findley, P 2018, 'Food Security and Unmet Dental Care Needs in Adults in the United States', Journal of dental hygiene : JDH, vol. 92, no. 3, pp. 14-22.
Roman-Gonzalez, A, Zhou, S, Ayala-Ramirez, M, Shen, C, Waguespack, SG, Habra, MA, Karam, JA, Perrier, N, Wood, CG & Jimenez, C 2018, 'Impact of Surgical Resection of the Primary Tumor on Overall Survival in Patients with Metastatic Pheochromocytoma or Sympathetic Paraganglioma', Annals of surgery, vol. 268, no. 1, pp. 172-178. https://doi.org/10.1097/SLA.0000000000002195
Nili, M, Shen, C & Sambamoorthi, U 2020, 'Low-value care: antipsychotic medication use among community-dwelling medicare beneficiaries with Alzheimer’s disease and related dementias and without severe mental illness', Aging and Mental Health, vol. 24, no. 3, pp. 504-510. https://doi.org/10.1080/13607863.2018.1544211
Shen, C, Zhao, X, Dwibedi, N, Wiener, RC, Findley, PA & Sambamoorthi, U 2018, 'Opioid use and the presence of Alzheimer's disease and related dementias among elderly Medicare beneficiaries diagnosed with chronic pain conditions', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 4, pp. 661-668. https://doi.org/10.1016/j.trci.2018.10.012
Shen, C, Dasari, A, Xu, Y, Zhou, S, Gu, D, Chu, Y, Halperin, DM, Shih, YT & Yao, JC 2018, 'Pre-existing Symptoms and Healthcare Utilization Prior to Diagnosis of Neuroendocrine Tumors: A SEER-Medicare Database Study', Scientific reports, vol. 8, no. 1, 16863. https://doi.org/10.1038/s41598-018-35340-4
Liu, W, Chen, J, Tamayo, AT, Ruan, C, Li, L, Zhou, S, Shen, C, Young, KH, Westin, J, Davis, RE, Hu, S, Medeiros, LJ, Ford, RJ & Pham, LV 2018, 'Preclinical efficacy and biological effects of the oral proteasome inhibitor ixazomib in diffuse large B-cell lymphoma', Oncotarget, vol. 9, no. 1, pp. 346-360. https://doi.org/10.18632/oncotarget.20378

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)