Researcher Profile

Researcher Profile

Chan Shen, PhD

Chan Shen, PhD

Associate Professor, Department of Surgery
Chief, Division of Outcomes, Research and Quality
Scientific Program:Cancer Control

Research Interests

  • Medicare
  • Elderly
  • Therapeutics
  • Neoplasms
  • Neuroendocrine Tumors
  • Costs and Cost Analysis
  • Depression
  • Delivery of Health Care
  • Survival
  • Health Expenditures
  • Logistic Models
  • Population

Recent Publications


Gu, D, Morgan, RO, Li, R, Weber, ES & Shen, C 2020, 'Association between depression and healthcare expenditures among elderly cancer patients', BMC psychiatry, vol. 20, no. 1, 131.
Gu, D & Shen, C 2020, 'Cost-Related Medication Nonadherence and Cost-Reduction Strategies among Elderly Cancer Survivors with Self-Reported Symptoms of Depression', Population Health Management, vol. 23, no. 2, pp. 132-139.
Shen, C, Gu, D, Klein, R, Zhou, S, Shih, YCT, Tracy, T, Soybel, D & Dillon, P 2020, 'Factors Associated With Hospital Decisions to Purchase Robotic Surgical Systems', MDM Policy and Practice, vol. 5, no. 1.
Downs, CG, Varisco, TJ, Bapat, SS, Shen, C & Thornton, JD 2020, 'Impact of COVID-19 related policy changes on filling of opioid and benzodiazepine medications', Research in Social and Administrative Pharmacy.
Shen, C, Thornton, JD, Gu, D, Dodge, D, Zhou, S, He, W, Zhao, H & Giordano, SH 2020, 'Prolonged Opioid Use After Surgery for Early-Stage Breast Cancer', Oncologist.
Abudayyeh, A, Song, J, Abdelrahim, M, Dahbour, I, Page, VD, Zhou, S, Shen, C, Zhao, B, Pai, RN, Amaram-Davila, J, Manzano, JG, George, MC, Yennu, S, Mandayam, SA, Nates, JL & Moss, AH 2020, 'Renal Replacement Therapy in Patients With Stage IV Cancer Admitted to the Intensive Care Unit With Acute Kidney Injury at a Comprehensive Cancer Center Was Not Associated With Survival', American Journal of Hospice and Palliative Medicine.


Gu, D & Shen, C 2019, 'Assessing the Importance of Factors Associated with Cost-Related Nonadherence to Medication for Older US Medicare Beneficiaries', Drugs and Aging, vol. 36, no. 12, pp. 1111-1121.
Dwibedi, N, Wiener, RC, Findley, PA, Shen, C & Sambamoorthi, U 2019, 'Asthma, chronic obstructive pulmonary disease, tooth loss, and edentulism among adults in the United States: 2016 Behavioral Risk Factor Surveillance System survey', Journal of the American Dental Association.
Findley, PA, Wiener, RC, Shen, C, Dwibedi, N & Sambamoorthi, U 2019, 'Health reform under the patient protection and Affordable Care Act: characteristics of exchange-based health insurance enrollees', Social Work in Health Care, vol. 58, no. 7, pp. 685-702.
Fried, DA, Sadeghi-Nejad, H, Gu, D, Zhou, S, He, W, Giordano, SH, Pentakota, SR, Demissie, K, Helmer, D & Shen, C 2019, 'Impact of serious mental illness on the treatment and mortality of older patients with locoregional high-grade (nonmetastatic) prostate cancer: retrospective cohort analysis of 49 985 SEER-Medicare patients diagnosed between 2006 and 2013', Cancer medicine, vol. 8, no. 5, pp. 2612-2622.
Shen, C, Gu, D, Zhou, S, Xu, Y, Sarshekeh, AM, Halperin, D, Shih, YCT, Yao, JC & Dasari, A 2019, 'Racial Differences in the Incidence and Survival of Patients with Neuroendocrine Tumors', Pancreas, vol. 48, no. 10, pp. 1373-1379.
Wang, Y, Zhou, S, Yang, F, Qi, X, Wang, X, Guan, X, Shen, C, Duma, N, Vera Aguilera, J, Chintakuntlawar, A, Price, KA, Molina, JR, Pagliaro, LC, Halfdanarson, TR, Grothey, A, Markovic, SN, Nowakowski, GS, Ansell, SM & Wang, ML 2019, 'Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis', JAMA Oncology, vol. 5, no. 7, pp. 1008-1019.


Shen, C, Zhao, B, Liu, L & Shih, YCT 2018, 'Adherence to tyrosine kinase inhibitors among Medicare Part D beneficiaries with chronic myeloid leukemia', Cancer, vol. 124, no. 2, pp. 364-373.
Dwibedi, N, Findley, PA, Wiener, CR, Shen, C & Sambamoorthi, U 2018, 'Alzheimer Disease and Related Disorders and Out-of-Pocket Health Care Spending and Burden among Elderly Medicare Beneficiaries', Medical care, vol. 56, no. 3, pp. 240-246.
Shen, C, Dasari, A, Gu, D, Chu, Y, Zhou, S, Xu, Y, Halperin, D, Fu, S, Yao, JC & Shih, YCT 2018, 'Costs of Cancer Care for Elderly Patients with Neuroendocrine Tumors', PharmacoEconomics, vol. 36, no. 8, pp. 1005-1013.
Wiener, RC, Shen, C, Findley, P, Tan, X & Sambamoorthi, U 2018, 'Dental Fluorosis over Time: A comparison of National Health and Nutrition Examination Survey data from 2001-2002 and 2011-2012', Journal of dental hygiene : JDH, vol. 92, no. 1, pp. 23-29.
Wiener, RC, Shen, C, Findley, PA, Dwibedi, N & Sambamoorthi, U 2018, 'Depressive symptoms and untreated coronal dental caries among adults ages 21-64 years, NHANES 2013-2014', Community dental health, vol. 35, no. 3, pp. 179-185.
Wiener, RC, Sambamoorthi, U, Shen, C, Alwhaibi, M & Findley, P 2018, 'Food Security and Unmet Dental Care Needs in Adults in the United States', Journal of dental hygiene : JDH, vol. 92, no. 3, pp. 14-22.
Roman-Gonzalez, A, Zhou, S, Ayala-Ramirez, M, Shen, C, Waguespack, SG, Habra, MA, Karam, JA, Perrier, N, Wood, CG & Jimenez, C 2018, 'Impact of Surgical Resection of the Primary Tumor on Overall Survival in Patients with Metastatic Pheochromocytoma or Sympathetic Paraganglioma', Annals of surgery, vol. 268, no. 1, pp. 172-178.
Nili, M, Shen, C & Sambamoorthi, U 2020, 'Low-value care: antipsychotic medication use among community-dwelling medicare beneficiaries with Alzheimer’s disease and related dementias and without severe mental illness', Aging and Mental Health, vol. 24, no. 3, pp. 504-510.
Shen, C, Zhao, X, Dwibedi, N, Wiener, RC, Findley, PA & Sambamoorthi, U 2018, 'Opioid use and the presence of Alzheimer's disease and related dementias among elderly Medicare beneficiaries diagnosed with chronic pain conditions', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 4, pp. 661-668.
Shen, C, Dasari, A, Xu, Y, Zhou, S, Gu, D, Chu, Y, Halperin, DM, Shih, YT & Yao, JC 2018, 'Pre-existing Symptoms and Healthcare Utilization Prior to Diagnosis of Neuroendocrine Tumors: A SEER-Medicare Database Study', Scientific reports, vol. 8, no. 1, 16863.
Liu, W, Chen, J, Tamayo, AT, Ruan, C, Li, L, Zhou, S, Shen, C, Young, KH, Westin, J, Davis, RE, Hu, S, Medeiros, LJ, Ford, RJ & Pham, LV 2018, 'Preclinical efficacy and biological effects of the oral proteasome inhibitor ixazomib in diffuse large B-cell lymphoma', Oncotarget, vol. 9, no. 1, pp. 346-360.


Ajmera, M, Shen, C & Sambamoorthi, U 2017, 'Association Between Statin Medications and COPD-Specific Outcomes: A Real-World Observational Study', Drugs - Real World Outcomes, vol. 4, no. 1, pp. 9-19.
Shen, C, Chu, Y, Halperin, DM, Dasari, A, Zhou, S, Xu, Y, Yao, JC & Shih, YCT 2017, 'Carcinoid syndrome and costs of care during the first year after diagnosis of neuroendocrine tumors among elderly patients', Oncologist, vol. 22, no. 12, pp. 1451-1462.
Shen, C, Dasari, A, Chu, Y, Halperin, DM, Zhou, S, Xu, Y, Shih, YT & Yao, JC 2017, 'Clinical, pathological, and demographic factors associated with development of recurrences after surgical resection in elderly patients with neuroendocrine tumors', Annals of oncology : official journal of the European Society for Medical Oncology, vol. 28, no. 7, pp. 1582-1589.
Ajmera, M, Shen, C & Sambamoorthi, U 2017, 'Concomitant Medication Use and New-Onset Diabetes among Medicaid Beneficiaries with Chronic Obstructive Pulmonary Disease', Population Health Management, vol. 20, no. 3, pp. 224-232.
Shih, YCT, Shen, C & Hu, JC 2017, 'Do Robotic Surgical Systems Improve Profit Margins? A Cross-Sectional Analysis of California Hospitals', Value in Health, vol. 20, no. 8, pp. 1221-1225.
Shen, C, Zhao, B, Liu, L & Shih, YCT 2017, 'Financial burden for patients with chronic myeloid leukemia enrolled in medicare part D taking targeted oral anticancer medications', Journal of oncology practice, vol. 13, no. 2, pp. e152-e162.
Halperin, DM, Shen, C, Dasari, A, Xu, Y, Chu, Y, Zhou, S, Shih, YCT & Yao, JC 2017, 'Frequency of carcinoid syndrome at neuroendocrine tumour diagnosis: a population-based study', The Lancet Oncology, vol. 18, no. 4, pp. 525-534.
Halperin, DM, Shen, C & Yao, JC 2017, 'Incidence and prognosis of carcinoid syndrome: hormones or tumour burden? – Authors' reply', The Lancet Oncology, vol. 18, no. 6, pp. e300.
Chang, JY, Zhang, W, Komaki, R, Choi, NC, Chan, S, Gomez, D, O'Reilly, M, Jeter, M, Gillin, M, Zhu, X, Zhang, X, Mohan, R, Swisher, S, Hahn, S & Cox, JD 2017, 'Long-term outcome of phase I/II prospective study of dose-escalated proton therapy for early-stage non-small cell lung cancer', Radiotherapy and Oncology, vol. 122, no. 2, pp. 274-280.
Sarshekeh, AM, Advani, S, Halperin, DM, Conrad, C, Shen, C, Yao, JC & Dasari, A 2017, 'Regional lymph node involvement and outcomes in appendiceal neuroendocrine tumors: A SEER database analysis', Oncotarget, vol. 8, no. 59, pp. 99541-99551.
Wiener, RC, Shen, C, Sambamoorthi, U & Findley, PA 2017, 'Rural Veterans' dental utilization, Behavioral Risk Factor Surveillance Survey, 2014', Journal of Public Health Dentistry, vol. 77, no. 4, pp. 383-392.
Wiener, RC, Shen, C, Findley, PA, Sambamoorthi, U & Tan, X 2017, 'The association between diabetes mellitus, sugar-sweetened beverages, and tooth loss in adults: Evidence from 18 states', Journal of the American Dental Association, vol. 148, no. 7, pp. 500-509.e4.
Dasari, A, Shen, C, Halperin, D, Zhao, B, Zhou, S, Xu, Y, Shih, T & Yao, JC 2017, 'Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States', JAMA Oncology, vol. 3, no. 10, pp. 1335-1342.
Huo, J, Shen, C, Volk, RJ & Shih, YCT 2017, 'Use of CT and chest radiography for lung cancer screening before and after publication of screening guidelines: Intended and unintended uptake', JAMA Internal Medicine, vol. 177, no. 3, pp. 439-441.
Shen, C, Kehl, KL, Zhao, B, Simon, GR, Zhou, S & Giordano, SH 2017, 'Utilization Patterns and Trends in Epidermal Growth Factor Receptor (EGFR) Mutation Testing Among Patients With Newly Diagnosed Metastatic Lung Cancer', Clinical Lung Cancer, vol. 18, no. 4, pp. e233-e241.


Bhattacharya, R, Shen, C, Wachholtz, AB, Dwibedi, N & Sambamoorthi, U 2016, 'Depression treatment decreases healthcare expenditures among working age patients with comorbid conditions and type 2 diabetes mellitus along with newly-diagnosed depression', BMC psychiatry, vol. 16, no. 1, 247.
Kehl, KL, Shen, C, Litton, JK, Arun, B & Giordano, SH 2016, 'Erratum to: Rates of BRCA1/2 mutation testing among young survivors of breast cancer (Breast Cancer Res Treat, (2016), 155, (165-173), 10.1007/s10549-015-3658-y)', Breast Cancer Research and Treatment, vol. 159, no. 1.
Giordano, SH, Niu, J, Chavez-MacGregor, M, Zhao, H, Zorzi, D, Shih, YCT, Smith, BD & Shen, C 2016, 'Estimating regimen-specific costs of chemotherapy for breast cancer: Observational cohort study', Cancer, vol. 122, no. 22, pp. 3447-3455.
Shen, C, Xu, Y, Dasari, A, Tina Shih, YC & Yao, JC 2016, 'Octreotide LAR dosage and survival among elderly patients with distant-stage neuroendocrine tumors', Oncologist, vol. 21, no. 3, pp. 308-313.
Zhao, L, Zhou, S, Balter, P, Shen, C, Gomez, DR, Welsh, JD, Lin, SH & Chang, JY 2016, 'Planning target volume d95 and mean dose should be considered for optimal local control for stereotactic ablative radiation therapy', International Journal of Radiation Oncology Biology Physics, vol. 95, no. 4, pp. 1226-1235.
Shen, C, Meric-Bernstam, F, Su, X, Mendelsohn, J & Giordano, S 2016, 'Prevalence of actionable mutations and copy number alterations and the price of a genomic testing panel', Oncotarget, vol. 7, no. 44, pp. 71686-71695.
Wiener, RC, Shen, C, Sambamoorthi, N & Sambamoorthi, U 2016, 'Preventive dental care in older adults with diabetes', Journal of the American Dental Association, vol. 147, no. 10, pp. 797-802.
Kehl, KL, Shen, C, Litton, JK, Arun, B & Giordano, SH 2016, 'Rates of BRCA1/2 mutation testing among young survivors of breast cancer', Breast Cancer Research and Treatment, vol. 155, no. 1, pp. 165-173.
Shen, C & Tina Shih, YC 2016, 'Therapeutic substitutions in the midst of new technology diffusion: The case of treatment for localized prostate cancer', Social Science and Medicine, vol. 151, pp. 110-120.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)