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Researcher Profile

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Chan Shen, PhD

Chan Shen, PhD

Associate Professor, Department of Surgery
Chief, Division of Outcomes, Research and Quality
Scientific Program:Cancer Control

Research Interests

  • Therapeutics
  • Neoplasms
  • Medicare
  • Survival
  • Elderly
  • Breast Neoplasms
  • Costs and Cost Analysis
  • Neuroendocrine Tumors
  • Delivery of Health Care
  • Health Expenditures
  • Depression
  • Logistic Models

Recent Publications


Wang, H, Shen, C, Barbaro, M, Ho, AF, Pathak, M, Dunn, C & Sambamoorthi, U 2023, 'A Multi-Level Analysis of Individual and Neighborhood Factors Associated with Patient Portal Use among Adult Emergency Department Patients with Multimorbidity', International journal of environmental research and public health, vol. 20, no. 2, 1231.
Wong, WG, Dasari, A & Shen, C 2023, 'Association of Surgery and Chemotherapy in Stage IV Gastroenteropancreatic Neuroendocrine Carcinoma', Journal of Surgical Research, vol. 283, pp. 407-415.
Wiener, RC, Findley, PA, Shen, C, Wang, H, Mitra, S & Sambamoorthi, U 2023, 'Cost Conversation Research', Journal of the American Dental Association, vol. 154, no. 1, pp. 6-7.
Perez Holguin, RA, DeAngelo, N, Sinha, A, Shen, C & Tsai, AY 2023, 'Cost and outcomes of intercostal nerve cryoablation versus thoracic epidural following the Nuss procedure', Journal of pediatric surgery, vol. 58, no. 4, pp. 608-612.
Zhou, S & Shen, C 2023, 'Efficacy and safety associated with immune checkpoint inhibitors in unresectable hepatocellular carcinoma: A re-analysis of a meta-analysis', JGH Open, vol. 7, no. 2, pp. 163-164.


Weng, X, Shen, C, Van Scoy, LJ, Boltz, M, Joshi, M & Wang, L 2022, 'A comparison of end-of-life care patterns between older patients with both cancer and Alzheimer's disease and related dementias versus those with only cancer', Journal of Geriatric Oncology, vol. 13, no. 8, pp. 1111-1121.
Arhin, N, Ssentongo, P, Taylor, M, Olecki, EJ, Pameijer, C, Shen, C, Oh, J & Eng, C 2022, 'Age-standardised incidence rate and epidemiology of colorectal cancer in Africa: A systematic review and meta-analysis', BMJ open, vol. 12, no. 1, e052376.
Wong, WG, Perez Holguin, RA, Tarren, AY, Shen, C, Vining, C, Peng, J & Dixon, ME 2022, 'Albumin-bilirubin score is superior to platelet-albumin-bilirubin score and model for end-state liver disease sodium for predicting posthepatectomy liver failure', Journal of Surgical Oncology, vol. 126, no. 4, pp. 667-679.
Weng, X, Shen, C, Vasekar, M, Boltz, M, Joshi, M, Van Scoy, LJ & Wang, L 2022, 'Alzheimer's disease and related dementias is a risk factor for lower utilization of breast cancer screening and unstaged cancer diagnosis: Observational study from SEER-Medicare 2004–2016 data', Journal of Geriatric Oncology.
Zukowski, M, Haas, A, Schaefer, EW, Shen, C, Reed, MF, Taylor, MD & Go, PH 2022, 'Are Routine Chest Radiographs After Chest Tube Removal in Thoracic Surgery Patients Necessary?', Journal of Surgical Research, vol. 276, pp. 160-167.
Zhou, S & Shen, C 2022, 'Avoiding Definitive Conclusions in Meta-analysis of Heterogeneous Studies with Small Sample Sizes', JAMA Otolaryngology - Head and Neck Surgery, vol. 148, no. 11, pp. 1003-1004.
Benavides-Vasquez, J, Shen, C, McDonald, A & Wang, L 2023, 'Effect of residence in nonmetropolitan counties on stage and tumor size at diagnosis in patients with breast cancer: A Surveillance, Epidemiology, and End Results analysis', Journal of Rural Health, vol. 39, no. 2, pp. 408-415.
Weng, X, Shen, C, Van Scoy, LJ, Boltz, M, Joshi, M & Wang, L 2022, 'End-of-Life Costs of Cancer Patients With Alzheimer's Disease and Related Dementias in the U.S.', Journal of Pain and Symptom Management, vol. 64, no. 5, pp. 449-460.
Shen, C, Li, N, Zhou, S, Stahl, K, Dodge, D & Zhao, H 2023, 'Endocrine therapy initiation and overall survival outcomes with omission of radiation therapy in older Medicare patients with early-stage hormone-receptor-positive breast cancer', Cancer medicine, vol. 12, no. 6, pp. 6935-6944.
Holguin, RAP, Wong, WG, Shen, C, Go, PH, Reed, MF & Taylor, MD 2022, 'Esophagectomy vs Gastrectomy for Early Stage Adenocarcinoma of the Gastroesophageal Junction: What is the Optimal Oncologic Surgical Treatment?', Seminars in thoracic and cardiovascular surgery.
Stahl, KA, Dodge, D, Olecki, EJ, Holguin, RP, McLaughlin, C, Wong, W & Shen, C 2022, 'Insurance Status and Travel Distance to Single Treatment Facility Predictive of Mastectomy', Journal of Surgical Research, vol. 270, pp. 22-30.
Shen, C & Moss, JL 2022, 'Large variations in hospital pricing for standard procedures revealed', BMC Research Notes, vol. 15, no. 1, 129.
Perez Holguin, RA, Olecki, EJ, Wong, WG, Stahl, KA, Go, PH, Taylor, MD, Reed, MF & Shen, C 2023, 'Outcomes after sublobar resection versus lobectomy in non–small cell carcinoma in situ', Journal of Thoracic and Cardiovascular Surgery, vol. 165, no. 3, pp. 853-861.e3.
Shen, C, Tannenbaum, D, Horn, R, Rogers, J, Eng, C, Zhou, S, Johnson, B, Kopetz, S, Morris, V, Overman, M, Parseghian, C, Chang, GJ, Lopez-Olivo, MA, Kanwal, R, Ellis, LM & Dasari, A 2022, 'Overall Survival in Phase 3 Clinical Trials and the Surveillance, Epidemiology, and End Results Database in Patients with Metastatic Colorectal Cancer, 1986-2016: A Systematic Review', JAMA network open.
Wong, W, Perez Holguin, RA, Olecki, EJ, Stahl, KA, Dixon, M, Peng, J, Dasari, A & Shen, C 2022, 'Predictors and Outcomes of Minimally Invasive Surgery for Small Bowel Neuroendocrine Tumors: Minimally Invasive Surgery for SBNETs', Journal of Gastrointestinal Surgery, vol. 26, no. 6, pp. 1252-1265.
Perez Holguin, RA, Stahl, KA, Hendriksen, BS, Wong, WG, Olecki, EJ, Vining, CC, Dixon, ME, Peng, JS & Shen, C 2022, 'Predictors of Conversion During Minimally Invasive Gastrectomy for Malignancy', Journal of Surgical Research, vol. 279, pp. 275-284.
Wong, WG, Perez Holguin, RA, Butt, M, Rigby, A, Rogers, AM & Shen, C 2022, 'Racial Differences in Bariatric Surgical Approach: a Cross-Sectional National Inpatient Sample Analysis', Obesity Surgery, vol. 32, no. 10, pp. 3359-3367.
Shen, C, Jain, K, Shah, T, Schaefer, E, Zhou, S, Fried, D, Helmer, DA & Sadeghi-Nejad, H 2022, 'Relationships between erectile dysfunction, prostate cancer treatment type and inflatable penile prosthesis implantation', Investigative and Clinical Urology, vol. 63, no. 3, pp. 316-324.
Zhou, S, Liu, X, Fang, X, Chinchilli, VM, Wang, M, Wang, HG, Dokholyan, NV, Shen, C & Lee, JJ 2022, 'Robust and Efficient Assessment of Potency (REAP) as a quantitative tool for dose-response curve estimation', eLife, vol. 11, e78634.
Zhou, S & Shen, C 2022, 'Statistical Considerations for Meta-analysis of Diabetic Retinopathy Prevalence', JAMA Ophthalmology, vol. 140, no. 11, pp. 1141.
Zhou, S & Shen, C 2022, 'Statistical concerns for meta-analysis of rare events and small sample sizes', The Lancet Infectious Diseases, vol. 22, no. 8, pp. 1111-1112.
Dasari, A, Shen, C, Devabhaktuni, A, Nighot, R & Sorbye, H 2022, 'Survival According to Primary Tumor Location, Stage, and Treatment Patterns in Locoregional Gastroenteropancreatic High-grade Neuroendocrine Carcinomas', Oncologist, vol. 27, no. 4, pp. 299-306.
Shen, C, Rashiwala, L, Wiener, RC, Findley, PA, Wang, H & Sambamoorthi, U 2022, 'The association of COVID-19 vaccine availability with mental health among adults in the United States', Frontiers in Psychiatry, vol. 13, 970007.
Lapelusa, M, Shen, C, Arhin, ND, Cardin, D, Tan, M, Idrees, K, Geevarghese, S, Chakravarthy, B, Berlin, J & Eng, C 2022, 'Trends in the Incidence and Treatment of Early-Onset Pancreatic Cancer', Cancers, vol. 14, no. 2, 283.
Shen, C, Holguin, RAP, Schaefer, E, Zhou, S, Belani, CP, Ma, PC & Reed, MF 2022, 'Utilization and costs of epidermal growth factor receptor mutation testing and targeted therapy in Medicare patients with metastatic lung adenocarcinoma', BMC health services research, vol. 22, no. 1, 470.
Shen, C, Kwon, M, Moss, JL, Schaefer, E, Zhou, S, Dodge, D & Ruffin, MT 2022, 'Utilization of Mammography During the Last Year of Life Among Older Breast Cancer Survivors', Journal of Women's Health, vol. 31, no. 7, pp. 941-948.
LaPelusa, M, Shen, C, Gillaspie, EA, Cann, C, Lambright, E, Chakravarthy, AB, Gibson, MK & Eng, C 2022, 'Variation in Treatment Patterns of Patients with Early-Onset Gastric Cancer', Cancers, vol. 14, no. 15, 3633.


Stahl, K, Dodge, D, Wong, W & Shen, C 2022, 'ASO Author Reflection: Trimodality Therapy Offers Survival Advantage in Metastatic Male Breast Cancer', Annals of Surgical Oncology, vol. 29, no. 2, pp. 1018.
Wiener, RC, Findley, PA, Shen, C, Dwibedi, N & Sambamoorthi, U 2022, 'Acculturation and dental sealant use among US children', Community Dentistry and Oral Epidemiology.
Olecki, EJ, Stahl, KA, Torres, MB, Peng, JS, Dixon, M, Shen, C & Gusani, NJ 2021, 'Adjuvant Chemotherapy After Neoadjuvant Chemotherapy for Pancreatic Cancer is Associated with Improved Survival for Patients with Low-Risk Pathology', Annals of Surgical Oncology, vol. 28, no. 6, pp. 3111-3122.
Klein, R & Shen, C 2021, 'An IV estimator for a functional coefficient model with endogenous discrete treatments', Econometric Reviews, vol. 40, no. 6, pp. 540-561.
Shen, C, Klein, RW, Moss, JL, Dodge, DG, Chetlen, AL, Stahl, KA, Zhou, S, Leslie, DL, Ruffin, MT & Lengerich, EJ 2021, 'Association Between Dense Breast Legislation and Cancer Stage at Diagnosis', American Journal of Preventive Medicine, vol. 61, no. 6, pp. 890-899.
Stahl, KA, Wong, W, Olecki, EJ, McLaughlin, C, Perez-Holguin, R, Lewcun, JA, Dodge, D & Shen, C 2022, 'Benefits of Trimodality Therapy Compared with Systemic Therapy Alone in Male Patients with Stage IV Breast Cancer', Annals of Surgical Oncology, vol. 29, no. 2, pp. 1005-1017.
Findley, PA, Wiener, RC, Shen, C, Dwibedi, N & Sambamoorthi, U 2021, 'Clinical Preventive Services and Self-Management Practices Among Adult Cancer Survivors in the United States Over Time', Cancer Control, vol. 28.
Wiener, RC, Findley, PA & Shen, C 2021, Dental and Oral Health. in Handbook of Rural Aging. Taylor and Francis, pp. 95-99.
Rai, P, Shen, C, Kolodney, J, Kelly, KM, Scott, VG & Sambamoorthi, U 2021, 'Factors associated with immune checkpoint inhibitor use among older adults with late-stage melanoma: A population-based study', Medicine, vol. 100, no. 7, pp. e24782.
Stahl, KA, Olecki, EJ, Dixon, ME, Peng, JS, Torres, MB, Gusani, NJ & Shen, C 2021, 'Gastric cancer treatments and survival trends in the United States', Current Oncology, vol. 28, no. 1, pp. 138-151.
Lewcun, J, Massand, S, Trangucci, J, Shen, C & Johnson, TS 2022, 'Head and Neck Free Flap Reconstruction in an Academic versus a Community Setting', Journal of Reconstructive Microsurgery, vol. 38, no. 6, pp. 466-471.
Rai, P, Shen, C, Kolodney, J, Kelly, KM, Scott, VG & Sambamoorthi, U 2021, 'Immune checkpoint inhibitor use, multimorbidity and healthcare expenditures among older adults with late-stage melanoma', Immunotherapy, vol. 13, no. 2, pp. 103-112.
Iloabuchi, C, Dwibedi, N, LeMasters, T, Shen, C, Ladani, A & Sambamoorthi, U 2021, 'Low-value care and excess out-of-pocket expenditure among older adults with incident cancer – A machine learning approach', Journal of Cancer Policy, vol. 30, 100312.
Olecki, EJ, Stahl, KA, Torres, MB, Peng, JS, Shen, C, Dixon, MEB & Gusani, NJ 2021, 'Pathologic upstaging in resected pancreatic adenocarcinoma: Risk factors and impact on survival', Journal of Surgical Oncology, vol. 124, no. 1, pp. 79-87.
Constance Wiener, R, Findley, PA, Shen, C, Dwibedi, N & Sambamoorthi, U 2021, 'Relationship between smoking status and muscle strength in the United States older adults', Epidemiology and health, vol. 42, e2020055.
Stahl, K, Dodge, D & Shen, C 2021, 'Surgery of the Primary Tumor in De Novo Metastatic Breast Cancer Confers No Survival Benefit: Author’s Reply', Annals of Surgical Oncology, vol. 28, pp. 789-790.
Arhin, ND, Shen, C, Bailey, CE, Matsuoka, LK, Hawkins, AT, Holowatyj, AN, Ciombor, KK, Hopkins, MB, Geiger, TM, Kam, AE, Roth, MT, Lebeck Lee, CM, Lapelusa, M, Dasari, A & Eng, C 2021, 'Surgical resection and survival outcomes in metastatic young adult colorectal cancer patients', Cancer medicine, vol. 10, no. 13, pp. 4269-4281.
Wong, WG, Stahl, K, Olecki, EJ, Holguin, RP, Pameijer, C & Shen, C 2021, 'Survival Benefit of Guideline-Concordant Postoperative Radiation for Local Merkel Cell Carcinoma', Journal of Surgical Research, vol. 266, pp. 168-179.


Olecki, E, Gusani, N & Shen, C 2021, 'ASO Author Reflections: Undertreatment of Pancreatic Cancer After Resection: Don’t Get Fooled by Favorable Final Pathology', Annals of Surgical Oncology, vol. 28, no. 3, pp. 1593-1594.
Gu, D, Morgan, RO, Li, R, Weber, ES & Shen, C 2020, 'Association between depression and healthcare expenditures among elderly cancer patients', BMC psychiatry, vol. 20, no. 1, 131.
Fiano, RM, Merrick, GS, Innes, KE, Mattes, MD, LeMasters, TJ, Shen, C & Sambamoorthi, U 2020, 'Associations of multimorbidity and patient-reported experiences of care with conservative management among elderly patients with localized prostate cancer', Cancer medicine, vol. 9, no. 16, pp. 6051-6061.
Stahl, K, Wong, W, Dodge, D, Brooks, A, McLaughlin, C, Olecki, E, Lewcun, J, Newport, K, Vasekar, M & Shen, C 2021, 'Benefits of Surgical Treatment of Stage IV Breast Cancer for Patients With Known Hormone Receptor and HER2 Status', Annals of Surgical Oncology, vol. 28, no. 5, pp. 2646-2658.
Varisco, T, Shen, C & Thornton, D 2020, 'Chronic prescription opioid use predicts stabilization on buprenorphine for the treatment of opioid use disorder', Journal of Substance Abuse Treatment, vol. 117, 108073.
Parham, CS, Shen, C, Pennock, MM, Henderson, SR, Kulaylat, AS & Johnson, TS 2020, 'Correlation between venous thromboembolism risk and venous congestion in microvascular reconstruction of the lower extremity', Plastic and reconstructive surgery, pp. 1177-1185.
Gu, D & Shen, C 2020, 'Cost-Related Medication Nonadherence and Cost-Reduction Strategies among Elderly Cancer Survivors with Self-Reported Symptoms of Depression', Population Health Management, vol. 23, no. 2, pp. 132-139.
Roy, S, Moss, JL, Rodriguez-Colon, SM, Shen, C, Cooper, JD, Lennon, RP, Lengerich, EJ, Adelman, A, Curry, W & Ruffin, MT 2020, 'Examining Older Adults’ Attitudes and Perceptions of Cancer Screening and Overscreening: A Qualitative Study', Journal of Primary Care and Community Health, vol. 11.
Shen, C, Gu, D, Klein, R, Zhou, S, Shih, YCT, Tracy, T, Soybel, D & Dillon, P 2020, 'Factors Associated With Hospital Decisions to Purchase Robotic Surgical Systems', MDM Policy and Practice, vol. 5, no. 1.
Moss, JL, Roy, S, Shen, C, Cooper, JD, Lennon, RP, Lengerich, EJ, Adelman, A, Curry, W & Ruffin, MT 2020, 'Geographic Variation in Overscreening for Colorectal, Cervical, and Breast Cancer Among Older Adults', JAMA network open, vol. 3, no. 7, pp. e2011645.
Wiener, RC, Findley, PA, Shen, C, Dwibedi, N & Sambamoorthi, U 2020, 'Human papillomavirus (HPV) vaccine utilization among adults (18–29 years), BRFSS 2015', Vaccine, vol. 38, no. 33, pp. 5119-5122.
Downs, CG, Varisco, TJ, Bapat, SS, Shen, C & Thornton, JD 2021, 'Impact of COVID-19 related policy changes on filling of opioid and benzodiazepine medications', Research in Social and Administrative Pharmacy, vol. 17, no. 1, pp. 2005-2008.
Rai, P, Shen, C, Kolodney, J, Kelly, KM, Scott, VG & Sambamoorthi, U 2021, 'Prevalence and risk factors for multimorbidity in older US patients with late-stage melanoma', Journal of Geriatric Oncology, vol. 12, no. 3, pp. 388-393.
Shen, C, Thornton, JD, Gu, D, Dodge, D, Zhou, S, He, W, Zhao, H & Giordano, SH 2020, 'Prolonged Opioid Use After Surgery for Early-Stage Breast Cancer', Oncologist, vol. 25, no. 10, pp. e1574-e1582.
Abudayyeh, A, Song, J, Abdelrahim, M, Dahbour, I, Page, VD, Zhou, S, Shen, C, Zhao, B, Pai, RN, Amaram-Davila, J, Manzano, JG, George, MC, Yennu, S, Mandayam, SA, Nates, JL & Moss, AH 2020, 'Renal Replacement Therapy in Patients With Stage IV Cancer Admitted to the Intensive Care Unit With Acute Kidney Injury at a Comprehensive Cancer Center Was Not Associated With Survival', American Journal of Hospice and Palliative Medicine, vol. 37, no. 9, pp. 707-715.
Shen, C, Thornton, JD, Newport, K, Schaefer, E, Zhou, S, Yee, NS, Dodge, D & Leslie, D 2020, 'Trends and patterns in the use of opioids among metastatic breast cancer patients', Scientific reports, vol. 10, no. 1, 21698.
Olecki, EJ, Stahl, K, Peng, JS, Dixon, M, Gusani, NJ & Shen, C 2021, 'Undertreatment of Pancreatic Cancer: Role of Surgical Pathology', Annals of Surgical Oncology, vol. 28, no. 3, pp. 1581-1592.


Gu, D & Shen, C 2019, 'Assessing the Importance of Factors Associated with Cost-Related Nonadherence to Medication for Older US Medicare Beneficiaries', Drugs and Aging, vol. 36, no. 12, pp. 1111-1121.
Dwibedi, N, Wiener, RC, Findley, PA, Shen, C & Sambamoorthi, U 2020, 'Asthma, chronic obstructive pulmonary disease, tooth loss, and edentulism among adults in the United States: 2016 Behavioral Risk Factor Surveillance System survey', Journal of the American Dental Association, vol. 151, no. 10, pp. 735-744.e1.
Shen, C, Dasari, A, Chu, Y, Halperin, DM, Zhou, S, Xu, Y, Shih, YT & Yao, JC 2019, 'Erratum: Clinical, pathological, and demographic factors associated with development of recurrences after surgical resection in elderly patients with neuroendocrine tumors (Annals of Oncology (2017) 28(7) (1582–1589), (S0923753419322616), (10.1093/annonc/mdx164))', Annals of Oncology, vol. 30, no. 11, pp. 1847.
Findley, PA, Wiener, RC, Shen, C, Dwibedi, N & Sambamoorthi, U 2019, 'Health reform under the patient protection and Affordable Care Act: characteristics of exchange-based health insurance enrollees', Social Work in Health Care, vol. 58, no. 7, pp. 685-702.
Fried, DA, Sadeghi-Nejad, H, Gu, D, Zhou, S, He, W, Giordano, SH, Pentakota, SR, Demissie, K, Helmer, D & Shen, C 2019, 'Impact of serious mental illness on the treatment and mortality of older patients with locoregional high-grade (nonmetastatic) prostate cancer: retrospective cohort analysis of 49 985 SEER-Medicare patients diagnosed between 2006 and 2013', Cancer medicine, vol. 8, no. 5, pp. 2612-2622.
Shen, C, Gu, D, Zhou, S, Xu, Y, Sarshekeh, AM, Halperin, D, Shih, YCT, Yao, JC & Dasari, A 2019, 'Racial Differences in the Incidence and Survival of Patients with Neuroendocrine Tumors', Pancreas, vol. 48, no. 10, pp. 1373-1379.
Wang, Y, Zhou, S, Yang, F, Qi, X, Wang, X, Guan, X, Shen, C, Duma, N, Vera Aguilera, J, Chintakuntlawar, A, Price, KA, Molina, JR, Pagliaro, LC, Halfdanarson, TR, Grothey, A, Markovic, SN, Nowakowski, GS, Ansell, SM & Wang, ML 2019, 'Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis', JAMA Oncology, vol. 5, no. 7, pp. 1008-1019.