Researcher Profile

Researcher Profile

Chan Shen, PhD

Chan Shen, PhD

Associate Professor, Department of Surgery
Chief, Division of Outcomes, Research and Quality
Scientific Program:Cancer Control
czs5992@psu.edu

Research Interests

  • Elderly
  • Medicare
  • Neoplasms
  • Therapeutics
  • Neuroendocrine Tumors
  • Delivery of Health Care
  • Costs and Cost Analysis
  • Survival
  • Depression
  • Breast Neoplasms
  • Health Expenditures
  • Logistic Models

Recent Publications

2021

Rai, P, Shen, C, Kolodney, J, Kelly, KM, Scott, VG & Sambamoorthi, U 2021, 'Immune checkpoint inhibitor use, multimorbidity and healthcare expenditures among older adults with late-stage melanoma', Immunotherapy, vol. 13, no. 2, pp. 103-112. https://doi.org/10.2217/imt-2020-0152

2020

Olecki, E, Gusani, NJ & Shen, C 2020, 'ASO Author Reflections: Undertreatment of Pancreatic Cancer After Resection: Don’t Get Fooled by Favorable Final Pathology', Annals of Surgical Oncology. https://doi.org/10.1245/s10434-020-09079-0
Gu, D, Morgan, RO, Li, R, Weber, ES & Shen, C 2020, 'Association between depression and healthcare expenditures among elderly cancer patients', BMC psychiatry, vol. 20, no. 1, 131. https://doi.org/10.1186/s12888-020-02527-x
Fiano, RM, Merrick, GS, Innes, KE, Mattes, MD, LeMasters, TJ, Shen, C & Sambamoorthi, U 2020, 'Associations of multimorbidity and patient-reported experiences of care with conservative management among elderly patients with localized prostate cancer', Cancer medicine, vol. 9, no. 16, pp. 6051-6061. https://doi.org/10.1002/cam4.3274
Stahl, K, Wong, W, Dodge, D, Brooks, A, McLaughlin, C, Olecki, E, Lewcun, J, Newport, K, Vasekar, M & Shen, C 2020, 'Benefits of Surgical Treatment of Stage IV Breast Cancer for Patients With Known Hormone Receptor and HER2 Status', Annals of Surgical Oncology. https://doi.org/10.1245/s10434-020-09244-5
Varisco, T, Shen, C & Thornton, D 2020, 'Chronic prescription opioid use predicts stabilization on buprenorphine for the treatment of opioid use disorder', Journal of Substance Abuse Treatment, vol. 117, 108073. https://doi.org/10.1016/j.jsat.2020.108073
Gu, D & Shen, C 2020, 'Cost-Related Medication Nonadherence and Cost-Reduction Strategies among Elderly Cancer Survivors with Self-Reported Symptoms of Depression', Population Health Management, vol. 23, no. 2, pp. 132-139. https://doi.org/10.1089/pop.2019.0035
Roy, S, Moss, JL, Rodriguez-Colon, SM, Shen, C, Cooper, JD, Lennon, RP, Lengerich, E, Adelman, A, Curry, W & Ruffin, MT 2020, 'Examining Older Adults’ Attitudes and Perceptions of Cancer Screening and Overscreening: A Qualitative Study', Journal of Primary Care and Community Health, vol. 11. https://doi.org/10.1177/2150132720959234
Shen, C, Gu, D, Klein, R, Zhou, S, Shih, YCT, Tracy, T, Soybel, D & Dillon, P 2020, 'Factors Associated With Hospital Decisions to Purchase Robotic Surgical Systems', MDM Policy and Practice, vol. 5, no. 1. https://doi.org/10.1177/2381468320904364
Moss, JL, Roy, S, Shen, C, Cooper, JD, Lennon, RP, Lengerich, EJ, Adelman, A, Curry, W & Ruffin, MT 2020, 'Geographic Variation in Overscreening for Colorectal, Cervical, and Breast Cancer Among Older Adults', JAMA network open, vol. 3, no. 7, pp. e2011645. https://doi.org/10.1001/jamanetworkopen.2020.11645
Wiener, RC, Findley, PA, Shen, C, Dwibedi, N & Sambamoorthi, U 2020, 'Human papillomavirus (HPV) vaccine utilization among adults (18–29 years), BRFSS 2015', Vaccine, vol. 38, no. 33, pp. 5119-5122. https://doi.org/10.1016/j.vaccine.2020.05.056
Downs, CG, Varisco, TJ, Bapat, SS, Shen, C & Thornton, JD 2021, 'Impact of COVID-19 related policy changes on filling of opioid and benzodiazepine medications', Research in Social and Administrative Pharmacy, vol. 17, no. 1, pp. 2005-2008. https://doi.org/10.1016/j.sapharm.2020.06.003
Rai, P, Shen, C, Kolodney, J, Kelly, KM, Scott, VG & Sambamoorthi, U 2020, 'Prevalence and risk factors for multimorbidity in older US patients with late-stage melanoma', Journal of Geriatric Oncology. https://doi.org/10.1016/j.jgo.2020.09.019
Shen, C, Thornton, JD, Gu, D, Dodge, D, Zhou, S, He, W, Zhao, H & Giordano, SH 2020, 'Prolonged Opioid Use After Surgery for Early-Stage Breast Cancer', Oncologist, vol. 25, no. 10, pp. e1574-e1582. https://doi.org/10.1634/theoncologist.2019-0868
Wiener, RC, Findley, PA, Shen, C, Dwibedi, N & Sambamoorthi, U 2020, 'Relationship between smoking status and muscle strength in the United States older adults', Epidemiology and health, vol. 42, pp. e2020055. https://doi.org/10.4178/epih.e2020055
Abudayyeh, A, Song, J, Abdelrahim, M, Dahbour, I, Page, VD, Zhou, S, Shen, C, Zhao, B, Pai, RN, Amaram-Davila, J, Manzano, JG, George, MC, Yennu, S, Mandayam, SA, Nates, JL & Moss, AH 2020, 'Renal Replacement Therapy in Patients With Stage IV Cancer Admitted to the Intensive Care Unit With Acute Kidney Injury at a Comprehensive Cancer Center Was Not Associated With Survival', American Journal of Hospice and Palliative Medicine, vol. 37, no. 9, pp. 707-715. https://doi.org/10.1177/1049909120902115
Shen, C, Thornton, JD, Newport, K, Schaefer, E, Zhou, S, Yee, NS, Dodge, D & Leslie, D 2020, 'Trends and patterns in the use of opioids among metastatic breast cancer patients', Scientific reports, vol. 10, no. 1, 21698. https://doi.org/10.1038/s41598-020-78569-8
Olecki, EJ, Stahl, K, Peng, J, Dixon, M, Gusani, NJ & Shen, C 2020, 'Undertreatment of Pancreatic Cancer: Role of Surgical Pathology', Annals of Surgical Oncology. https://doi.org/10.1245/s10434-020-09043-y

2019

Gu, D & Shen, C 2019, 'Assessing the Importance of Factors Associated with Cost-Related Nonadherence to Medication for Older US Medicare Beneficiaries', Drugs and Aging, vol. 36, no. 12, pp. 1111-1121. https://doi.org/10.1007/s40266-019-00715-3
Dwibedi, N, Wiener, RC, Findley, PA, Shen, C & Sambamoorthi, U 2020, 'Asthma, chronic obstructive pulmonary disease, tooth loss, and edentulism among adults in the United States: 2016 Behavioral Risk Factor Surveillance System survey', Journal of the American Dental Association, vol. 151, no. 10, pp. 735-744.e1. https://doi.org/10.1016/j.adaj.2019.07.032
Shen, C, Dasari, A, Chu, Y, Halperin, DM, Zhou, S, Xu, Y, Shih, YT & Yao, JC 2019, 'Erratum: Clinical, pathological, and demographic factors associated with development of recurrences after surgical resection in elderly patients with neuroendocrine tumors (Annals of Oncology (2017) 28(7) (1582–1589), (S0923753419322616), (10.1093/annonc/mdx164))', Annals of Oncology, vol. 30, no. 11, pp. 1847. https://doi.org/10.1093/annonc/mdz220
Findley, PA, Wiener, RC, Shen, C, Dwibedi, N & Sambamoorthi, U 2019, 'Health reform under the patient protection and Affordable Care Act: characteristics of exchange-based health insurance enrollees', Social Work in Health Care, vol. 58, no. 7, pp. 685-702. https://doi.org/10.1080/00981389.2019.1619116
Fried, DA, Sadeghi-Nejad, H, Gu, D, Zhou, S, He, W, Giordano, SH, Pentakota, SR, Demissie, K, Helmer, D & Shen, C 2019, 'Impact of serious mental illness on the treatment and mortality of older patients with locoregional high-grade (nonmetastatic) prostate cancer: retrospective cohort analysis of 49 985 SEER-Medicare patients diagnosed between 2006 and 2013', Cancer medicine, vol. 8, no. 5, pp. 2612-2622. https://doi.org/10.1002/cam4.2109
Shen, C, Gu, D, Zhou, S, Xu, Y, Sarshekeh, AM, Halperin, D, Shih, YCT, Yao, JC & Dasari, A 2019, 'Racial Differences in the Incidence and Survival of Patients with Neuroendocrine Tumors', Pancreas, vol. 48, no. 10, pp. 1373-1379. https://doi.org/10.1097/MPA.0000000000001431
Wang, Y, Zhou, S, Yang, F, Qi, X, Wang, X, Guan, X, Shen, C, Duma, N, Vera Aguilera, J, Chintakuntlawar, A, Price, KA, Molina, JR, Pagliaro, LC, Halfdanarson, TR, Grothey, A, Markovic, SN, Nowakowski, GS, Ansell, SM & Wang, ML 2019, 'Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis', JAMA Oncology, vol. 5, no. 7, pp. 1008-1019. https://doi.org/10.1001/jamaoncol.2019.0393

2018

Shen, C, Zhao, B, Liu, L & Shih, YCT 2018, 'Adherence to tyrosine kinase inhibitors among Medicare Part D beneficiaries with chronic myeloid leukemia', Cancer, vol. 124, no. 2, pp. 364-373. https://doi.org/10.1002/cncr.31050
Dwibedi, N, Findley, PA, Wiener, CR, Shen, C & Sambamoorthi, U 2018, 'Alzheimer Disease and Related Disorders and Out-of-Pocket Health Care Spending and Burden among Elderly Medicare Beneficiaries', Medical care, vol. 56, no. 3, pp. 240-246. https://doi.org/10.1097/MLR.0000000000000869
Shen, C, Dasari, A, Gu, D, Chu, Y, Zhou, S, Xu, Y, Halperin, D, Fu, S, Yao, JC & Shih, YCT 2018, 'Costs of Cancer Care for Elderly Patients with Neuroendocrine Tumors', PharmacoEconomics, vol. 36, no. 8, pp. 1005-1013. https://doi.org/10.1007/s40273-018-0656-z
Wiener, RC, Shen, C, Findley, P, Tan, X & Sambamoorthi, U 2018, 'Dental Fluorosis over Time: A comparison of National Health and Nutrition Examination Survey data from 2001-2002 and 2011-2012', Journal of dental hygiene : JDH, vol. 92, no. 1, pp. 23-29.
Wiener, RC, Shen, C, Findley, PA, Dwibedi, N & Sambamoorthi, U 2018, 'Depressive symptoms and untreated coronal dental caries among adults ages 21-64 years, NHANES 2013-2014', Community dental health, vol. 35, no. 3, pp. 179-185. https://doi.org/10.1922/CDH_4304Weiner07
Wiener, RC, Sambamoorthi, U, Shen, C, Alwhaibi, M & Findley, P 2018, 'Food Security and Unmet Dental Care Needs in Adults in the United States', Journal of dental hygiene : JDH, vol. 92, no. 3, pp. 14-22.
Roman-Gonzalez, A, Zhou, S, Ayala-Ramirez, M, Shen, C, Waguespack, SG, Habra, MA, Karam, JA, Perrier, N, Wood, CG & Jimenez, C 2018, 'Impact of Surgical Resection of the Primary Tumor on Overall Survival in Patients with Metastatic Pheochromocytoma or Sympathetic Paraganglioma', Annals of surgery, vol. 268, no. 1, pp. 172-178. https://doi.org/10.1097/SLA.0000000000002195
Nili, M, Shen, C & Sambamoorthi, U 2020, 'Low-value care: antipsychotic medication use among community-dwelling medicare beneficiaries with Alzheimer’s disease and related dementias and without severe mental illness', Aging and Mental Health, vol. 24, no. 3, pp. 504-510. https://doi.org/10.1080/13607863.2018.1544211
Shen, C, Zhao, X, Dwibedi, N, Wiener, RC, Findley, PA & Sambamoorthi, U 2018, 'Opioid use and the presence of Alzheimer's disease and related dementias among elderly Medicare beneficiaries diagnosed with chronic pain conditions', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 4, pp. 661-668. https://doi.org/10.1016/j.trci.2018.10.012
Shen, C, Dasari, A, Xu, Y, Zhou, S, Gu, D, Chu, Y, Halperin, DM, Shih, YT & Yao, JC 2018, 'Pre-existing Symptoms and Healthcare Utilization Prior to Diagnosis of Neuroendocrine Tumors: A SEER-Medicare Database Study', Scientific reports, vol. 8, no. 1, 16863. https://doi.org/10.1038/s41598-018-35340-4
Liu, W, Chen, J, Tamayo, AT, Ruan, C, Li, L, Zhou, S, Shen, C, Young, KH, Westin, J, Davis, RE, Hu, S, Medeiros, LJ, Ford, RJ & Pham, LV 2018, 'Preclinical efficacy and biological effects of the oral proteasome inhibitor ixazomib in diffuse large B-cell lymphoma', Oncotarget, vol. 9, no. 1, pp. 346-360. https://doi.org/10.18632/oncotarget.20378

2017

Ajmera, M, Shen, C & Sambamoorthi, U 2017, 'Association Between Statin Medications and COPD-Specific Outcomes: A Real-World Observational Study', Drugs - Real World Outcomes, vol. 4, no. 1, pp. 9-19. https://doi.org/10.1007/s40801-016-0101-6
Shen, C, Chu, Y, Halperin, DM, Dasari, A, Zhou, S, Xu, Y, Yao, JC & Shih, YCT 2017, 'Carcinoid syndrome and costs of care during the first year after diagnosis of neuroendocrine tumors among elderly patients', Oncologist, vol. 22, no. 12, pp. 1451-1462. https://doi.org/10.1634/theoncologist.2017-0149
Shen, C, Dasari, A, Chu, Y, Halperin, DM, Zhou, S, Xu, Y, Shih, YT & Yao, JC 2017, 'Clinical, pathological, and demographic factors associated with development of recurrences after surgical resection in elderly patients with neuroendocrine tumors', Annals of oncology : official journal of the European Society for Medical Oncology, vol. 28, no. 7, pp. 1582-1589. https://doi.org/10.1093/annonc/mdx164
Ajmera, M, Shen, C & Sambamoorthi, U 2017, 'Concomitant Medication Use and New-Onset Diabetes among Medicaid Beneficiaries with Chronic Obstructive Pulmonary Disease', Population Health Management, vol. 20, no. 3, pp. 224-232. https://doi.org/10.1089/pop.2016.0047
Shih, YCT, Shen, C & Hu, JC 2017, 'Do Robotic Surgical Systems Improve Profit Margins? A Cross-Sectional Analysis of California Hospitals', Value in Health, vol. 20, no. 8, pp. 1221-1225. https://doi.org/10.1016/j.jval.2017.05.010
Shen, C, Zhao, B, Liu, L & Shih, YCT 2017, 'Financial burden for patients with chronic myeloid leukemia enrolled in medicare part D taking targeted oral anticancer medications', Journal of oncology practice, vol. 13, no. 2, pp. e152-e162. https://doi.org/10.1200/JOP.2016.014639
Halperin, DM, Shen, C, Dasari, A, Xu, Y, Chu, Y, Zhou, S, Shih, YCT & Yao, JC 2017, 'Frequency of carcinoid syndrome at neuroendocrine tumour diagnosis: a population-based study', The Lancet Oncology, vol. 18, no. 4, pp. 525-534. https://doi.org/10.1016/S1470-2045(17)30110-9
Halperin, DM, Shen, C & Yao, JC 2017, 'Incidence and prognosis of carcinoid syndrome: hormones or tumour burden? – Authors' reply', The Lancet Oncology, vol. 18, no. 6, pp. e300. https://doi.org/10.1016/S1470-2045(17)30347-9
Chang, JY, Zhang, W, Komaki, R, Choi, NC, Chan, S, Gomez, D, O'Reilly, M, Jeter, M, Gillin, M, Zhu, X, Zhang, X, Mohan, R, Swisher, S, Hahn, S & Cox, JD 2017, 'Long-term outcome of phase I/II prospective study of dose-escalated proton therapy for early-stage non-small cell lung cancer', Radiotherapy and Oncology, vol. 122, no. 2, pp. 274-280. https://doi.org/10.1016/j.radonc.2016.10.022
Sarshekeh, AM, Advani, S, Halperin, DM, Conrad, C, Shen, C, Yao, JC & Dasari, A 2017, 'Regional lymph node involvement and outcomes in appendiceal neuroendocrine tumors: A SEER database analysis', Oncotarget, vol. 8, no. 59, pp. 99541-99551. https://doi.org/10.18632/oncotarget.20362
Wiener, RC, Shen, C, Sambamoorthi, U & Findley, PA 2017, 'Rural Veterans' dental utilization, Behavioral Risk Factor Surveillance Survey, 2014', Journal of Public Health Dentistry, vol. 77, no. 4, pp. 383-392. https://doi.org/10.1111/jphd.12230
Wiener, RC, Shen, C, Findley, PA, Sambamoorthi, U & Tan, X 2017, 'The association between diabetes mellitus, sugar-sweetened beverages, and tooth loss in adults: Evidence from 18 states', Journal of the American Dental Association, vol. 148, no. 7, pp. 500-509.e4. https://doi.org/10.1016/j.adaj.2017.03.012
Dasari, A, Shen, C, Halperin, D, Zhao, B, Zhou, S, Xu, Y, Shih, T & Yao, JC 2017, 'Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States', JAMA Oncology, vol. 3, no. 10, pp. 1335-1342. https://doi.org/10.1001/jamaoncol.2017.0589
Huo, J, Shen, C, Volk, RJ & Shih, YCT 2017, 'Use of CT and chest radiography for lung cancer screening before and after publication of screening guidelines: Intended and unintended uptake', JAMA Internal Medicine, vol. 177, no. 3, pp. 439-441. https://doi.org/10.1001/jamainternmed.2016.9016
Shen, C, Kehl, KL, Zhao, B, Simon, GR, Zhou, S & Giordano, SH 2017, 'Utilization Patterns and Trends in Epidermal Growth Factor Receptor (EGFR) Mutation Testing Among Patients With Newly Diagnosed Metastatic Lung Cancer', Clinical Lung Cancer, vol. 18, no. 4, pp. e233-e241. https://doi.org/10.1016/j.cllc.2016.11.002

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)