Researcher Profile

Researcher Profile

Chan Shen, PhD

Chan Shen, PhD

Associate Professor, Department of Surgery
Chief, Division of Outcomes, Research and Quality
Scientific Program:Cancer Control

Research Interests

  • Therapeutics
  • Neoplasms
  • Elderly
  • Medicare
  • Survival
  • Neuroendocrine Tumors
  • Breast Neoplasms
  • Delivery of Health Care
  • Health Expenditures
  • Costs and Cost Analysis
  • Depression
  • Population

Recent Publications


Arhin, N, Ssentongo, P, Taylor, M, Olecki, EJ, Pameijer, C, Shen, C, Oh, J & Eng, C 2022, 'Age-standardised incidence rate and epidemiology of colorectal cancer in Africa: A systematic review and meta-analysis', BMJ open, vol. 12, no. 1, e052376.
Stahl, KA, Dodge, D, Olecki, EJ, Holguin, RP, McLaughlin, C, Wong, W & Shen, C 2022, 'Insurance Status and Travel Distance to Single Treatment Facility Predictive of Mastectomy', Journal of Surgical Research, vol. 270, pp. 22-30.
Wong, W, Perez Holguin, RA, Olecki, EJ, Stahl, KA, Dixon, M, Peng, J, Dasari, A & Shen, C 2022, 'Predictors and Outcomes of Minimally Invasive Surgery for Small Bowel Neuroendocrine Tumors: Minimally Invasive Surgery for SBNETs', Journal of Gastrointestinal Surgery.
Lapelusa, M, Shen, C, Arhin, ND, Cardin, D, Tan, M, Idrees, K, Geevarghese, S, Chakravarthy, B, Berlin, J & Eng, C 2022, 'Trends in the Incidence and Treatment of Early-Onset Pancreatic Cancer', Cancers, vol. 14, no. 2, 283.
Shen, C, Holguin, RAP, Schaefer, E, Zhou, S, Belani, CP, Ma, PC & Reed, MF 2022, 'Utilization and costs of epidermal growth factor receptor mutation testing and targeted therapy in Medicare patients with metastatic lung adenocarcinoma', BMC health services research, vol. 22, no. 1, 470.


Stahl, K, Dodge, D, Wong, W & Shen, C 2022, 'ASO Author Reflection: Trimodality Therapy Offers Survival Advantage in Metastatic Male Breast Cancer', Annals of Surgical Oncology, vol. 29, no. 2, pp. 1018.
Olecki, EJ, Stahl, KA, Torres, MB, Peng, JS, Dixon, M, Shen, C & Gusani, NJ 2021, 'ASO Visual Abstract: Adjuvant Chemotherapy After Neoadjuvant Chemotherapy for Pancreatic Cancer is Associated with Improved Survival in Those with Low-Risk Pathology', Annals of Surgical Oncology, vol. 28, no. 6, pp. 3124.
Wiener, RC, Findley, PA, Shen, C, Dwibedi, N & Sambamoorthi, U 2021, 'Acculturation and dental sealant use among US children', Community Dentistry and Oral Epidemiology.
Olecki, EJ, Stahl, KA, Torres, MB, Peng, JS, Dixon, M, Shen, C & Gusani, NJ 2021, 'Adjuvant Chemotherapy After Neoadjuvant Chemotherapy for Pancreatic Cancer is Associated with Improved Survival for Patients with Low-Risk Pathology', Annals of Surgical Oncology, vol. 28, no. 6, pp. 3111-3122.
Klein, R & Shen, C 2021, 'An IV estimator for a functional coefficient model with endogenous discrete treatments', Econometric Reviews, vol. 40, no. 6, pp. 540-561.
Shen, C, Klein, RW, Moss, JL, Dodge, DG, Chetlen, AL, Stahl, KA, Zhou, S, Leslie, DL, Ruffin, MT & Lengerich, EJ 2021, 'Association Between Dense Breast Legislation and Cancer Stage at Diagnosis', American Journal of Preventive Medicine, vol. 61, no. 6, pp. 890-899.
Stahl, KA, Wong, W, Olecki, EJ, McLaughlin, C, Perez-Holguin, R, Lewcun, JA, Dodge, D & Shen, C 2022, 'Benefits of Trimodality Therapy Compared with Systemic Therapy Alone in Male Patients with Stage IV Breast Cancer', Annals of Surgical Oncology, vol. 29, no. 2, pp. 1005-1017.
Findley, PA, Wiener, RC, Shen, C, Dwibedi, N & Sambamoorthi, U 2021, 'Clinical Preventive Services and Self-Management Practices Among Adult Cancer Survivors in the United States Over Time', Cancer Control, vol. 28.
Wiener, RC, Findley, PA & Shen, C 2021, Dental and Oral Health. in Handbook of Rural Aging. Taylor and Francis, pp. 95-99.
Rai, P, Shen, C, Kolodney, J, Kelly, KM, Scott, VG & Sambamoorthi, U 2021, 'Factors associated with immune checkpoint inhibitor use among older adults with late-stage melanoma: A population-based study', Medicine, vol. 100, no. 7, pp. e24782.
Stahl, KA, Olecki, EJ, Dixon, ME, Peng, JS, Torres, MB, Gusani, NJ & Shen, C 2021, 'Gastric cancer treatments and survival trends in the United States', Current Oncology, vol. 28, no. 1, pp. 138-151.
Lewcun, J, Massand, S, Trangucci, J, Shen, C & Johnson, TS 2021, 'Head and Neck Free Flap Reconstruction in an Academic versus a Community Setting', Journal of Reconstructive Microsurgery.
Rai, P, Shen, C, Kolodney, J, Kelly, KM, Scott, VG & Sambamoorthi, U 2021, 'Immune checkpoint inhibitor use, multimorbidity and healthcare expenditures among older adults with late-stage melanoma', Immunotherapy, vol. 13, no. 2, pp. 103-112.
Iloabuchi, C, Dwibedi, N, LeMasters, T, Shen, C, Ladani, A & Sambamoorthi, U 2021, 'Low-value care and excess out-of-pocket expenditure among older adults with incident cancer – A machine learning approach', Journal of Cancer Policy, vol. 30, 100312.
Olecki, EJ, Stahl, KA, Torres, MB, Peng, JS, Shen, C, Dixon, MEB & Gusani, NJ 2021, 'Pathologic upstaging in resected pancreatic adenocarcinoma: Risk factors and impact on survival', Journal of Surgical Oncology, vol. 124, no. 1, pp. 79-87.
Constance Wiener, R, Findley, PA, Shen, C, Dwibedi, N & Sambamoorthi, U 2021, 'Relationship between smoking status and muscle strength in the United States older adults', Epidemiology and health, vol. 42, e2020055.
Stahl, K, Dodge, D & Shen, C 2021, 'Surgery of the Primary Tumor in De Novo Metastatic Breast Cancer Confers No Survival Benefit: Author’s Reply', Annals of Surgical Oncology, vol. 28, pp. 789-790.
Arhin, ND, Shen, C, Bailey, CE, Matsuoka, LK, Hawkins, AT, Holowatyj, AN, Ciombor, KK, Hopkins, MB, Geiger, TM, Kam, AE, Roth, MT, Lebeck Lee, CM, Lapelusa, M, Dasari, A & Eng, C 2021, 'Surgical resection and survival outcomes in metastatic young adult colorectal cancer patients', Cancer medicine, vol. 10, no. 13, pp. 4269-4281.
Wong, WG, Stahl, K, Olecki, EJ, Holguin, RP, Pameijer, C & Shen, C 2021, 'Survival Benefit of Guideline-Concordant Postoperative Radiation for Local Merkel Cell Carcinoma', Journal of Surgical Research, vol. 266, pp. 168-179.


Olecki, E, Gusani, N & Shen, C 2021, 'ASO Author Reflections: Undertreatment of Pancreatic Cancer After Resection: Don’t Get Fooled by Favorable Final Pathology', Annals of Surgical Oncology, vol. 28, no. 3, pp. 1593-1594.
Gu, D, Morgan, RO, Li, R, Weber, ES & Shen, C 2020, 'Association between depression and healthcare expenditures among elderly cancer patients', BMC psychiatry, vol. 20, no. 1, 131.
Fiano, RM, Merrick, GS, Innes, KE, Mattes, MD, LeMasters, TJ, Shen, C & Sambamoorthi, U 2020, 'Associations of multimorbidity and patient-reported experiences of care with conservative management among elderly patients with localized prostate cancer', Cancer medicine, vol. 9, no. 16, pp. 6051-6061.
Stahl, K, Wong, W, Dodge, D, Brooks, A, McLaughlin, C, Olecki, E, Lewcun, J, Newport, K, Vasekar, M & Shen, C 2021, 'Benefits of Surgical Treatment of Stage IV Breast Cancer for Patients With Known Hormone Receptor and HER2 Status', Annals of Surgical Oncology, vol. 28, no. 5, pp. 2646-2658.
Varisco, T, Shen, C & Thornton, D 2020, 'Chronic prescription opioid use predicts stabilization on buprenorphine for the treatment of opioid use disorder', Journal of Substance Abuse Treatment, vol. 117, 108073.
Parham, CS, Shen, C, Pennock, MM, Henderson, SR, Kulaylat, AS & Johnson, TS 2020, 'Correlation between venous thromboembolism risk and venous congestion in microvascular reconstruction of the lower extremity', Plastic and reconstructive surgery, pp. 1177-1185.
Gu, D & Shen, C 2020, 'Cost-Related Medication Nonadherence and Cost-Reduction Strategies among Elderly Cancer Survivors with Self-Reported Symptoms of Depression', Population Health Management, vol. 23, no. 2, pp. 132-139.
Roy, S, Moss, JL, Rodriguez-Colon, SM, Shen, C, Cooper, JD, Lennon, RP, Lengerich, EJ, Adelman, A, Curry, W & Ruffin, MT 2020, 'Examining Older Adults’ Attitudes and Perceptions of Cancer Screening and Overscreening: A Qualitative Study', Journal of Primary Care and Community Health, vol. 11.
Shen, C, Gu, D, Klein, R, Zhou, S, Shih, YCT, Tracy, T, Soybel, D & Dillon, P 2020, 'Factors Associated With Hospital Decisions to Purchase Robotic Surgical Systems', MDM Policy and Practice, vol. 5, no. 1.
Moss, JL, Roy, S, Shen, C, Cooper, JD, Lennon, RP, Lengerich, EJ, Adelman, A, Curry, W & Ruffin, MT 2020, 'Geographic Variation in Overscreening for Colorectal, Cervical, and Breast Cancer Among Older Adults', JAMA network open, vol. 3, no. 7, pp. e2011645.
Wiener, RC, Findley, PA, Shen, C, Dwibedi, N & Sambamoorthi, U 2020, 'Human papillomavirus (HPV) vaccine utilization among adults (18–29 years), BRFSS 2015', Vaccine, vol. 38, no. 33, pp. 5119-5122.
Downs, CG, Varisco, TJ, Bapat, SS, Shen, C & Thornton, JD 2021, 'Impact of COVID-19 related policy changes on filling of opioid and benzodiazepine medications', Research in Social and Administrative Pharmacy, vol. 17, no. 1, pp. 2005-2008.
Rai, P, Shen, C, Kolodney, J, Kelly, KM, Scott, VG & Sambamoorthi, U 2021, 'Prevalence and risk factors for multimorbidity in older US patients with late-stage melanoma', Journal of Geriatric Oncology, vol. 12, no. 3, pp. 388-393.
Shen, C, Thornton, JD, Gu, D, Dodge, D, Zhou, S, He, W, Zhao, H & Giordano, SH 2020, 'Prolonged Opioid Use After Surgery for Early-Stage Breast Cancer', Oncologist, vol. 25, no. 10, pp. e1574-e1582.
Abudayyeh, A, Song, J, Abdelrahim, M, Dahbour, I, Page, VD, Zhou, S, Shen, C, Zhao, B, Pai, RN, Amaram-Davila, J, Manzano, JG, George, MC, Yennu, S, Mandayam, SA, Nates, JL & Moss, AH 2020, 'Renal Replacement Therapy in Patients With Stage IV Cancer Admitted to the Intensive Care Unit With Acute Kidney Injury at a Comprehensive Cancer Center Was Not Associated With Survival', American Journal of Hospice and Palliative Medicine, vol. 37, no. 9, pp. 707-715.
Shen, C, Thornton, JD, Newport, K, Schaefer, E, Zhou, S, Yee, NS, Dodge, D & Leslie, D 2020, 'Trends and patterns in the use of opioids among metastatic breast cancer patients', Scientific reports, vol. 10, no. 1, 21698.
Olecki, EJ, Stahl, K, Peng, JS, Dixon, M, Gusani, NJ & Shen, C 2021, 'Undertreatment of Pancreatic Cancer: Role of Surgical Pathology', Annals of Surgical Oncology, vol. 28, no. 3, pp. 1581-1592.


Gu, D & Shen, C 2019, 'Assessing the Importance of Factors Associated with Cost-Related Nonadherence to Medication for Older US Medicare Beneficiaries', Drugs and Aging, vol. 36, no. 12, pp. 1111-1121.
Dwibedi, N, Wiener, RC, Findley, PA, Shen, C & Sambamoorthi, U 2020, 'Asthma, chronic obstructive pulmonary disease, tooth loss, and edentulism among adults in the United States: 2016 Behavioral Risk Factor Surveillance System survey', Journal of the American Dental Association, vol. 151, no. 10, pp. 735-744.e1.
Shen, C, Dasari, A, Chu, Y, Halperin, DM, Zhou, S, Xu, Y, Shih, YT & Yao, JC 2019, 'Erratum: Clinical, pathological, and demographic factors associated with development of recurrences after surgical resection in elderly patients with neuroendocrine tumors (Annals of Oncology (2017) 28(7) (1582–1589), (S0923753419322616), (10.1093/annonc/mdx164))', Annals of Oncology, vol. 30, no. 11, pp. 1847.
Findley, PA, Wiener, RC, Shen, C, Dwibedi, N & Sambamoorthi, U 2019, 'Health reform under the patient protection and Affordable Care Act: characteristics of exchange-based health insurance enrollees', Social Work in Health Care, vol. 58, no. 7, pp. 685-702.
Fried, DA, Sadeghi-Nejad, H, Gu, D, Zhou, S, He, W, Giordano, SH, Pentakota, SR, Demissie, K, Helmer, D & Shen, C 2019, 'Impact of serious mental illness on the treatment and mortality of older patients with locoregional high-grade (nonmetastatic) prostate cancer: retrospective cohort analysis of 49 985 SEER-Medicare patients diagnosed between 2006 and 2013', Cancer medicine, vol. 8, no. 5, pp. 2612-2622.
Shen, C, Gu, D, Zhou, S, Xu, Y, Sarshekeh, AM, Halperin, D, Shih, YCT, Yao, JC & Dasari, A 2019, 'Racial Differences in the Incidence and Survival of Patients with Neuroendocrine Tumors', Pancreas, vol. 48, no. 10, pp. 1373-1379.
Wang, Y, Zhou, S, Yang, F, Qi, X, Wang, X, Guan, X, Shen, C, Duma, N, Vera Aguilera, J, Chintakuntlawar, A, Price, KA, Molina, JR, Pagliaro, LC, Halfdanarson, TR, Grothey, A, Markovic, SN, Nowakowski, GS, Ansell, SM & Wang, ML 2019, 'Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis', JAMA Oncology, vol. 5, no. 7, pp. 1008-1019.


Shen, C, Zhao, B, Liu, L & Shih, YCT 2018, 'Adherence to tyrosine kinase inhibitors among Medicare Part D beneficiaries with chronic myeloid leukemia', Cancer, vol. 124, no. 2, pp. 364-373.
Dwibedi, N, Findley, PA, Wiener, CR, Shen, C & Sambamoorthi, U 2018, 'Alzheimer Disease and Related Disorders and Out-of-Pocket Health Care Spending and Burden among Elderly Medicare Beneficiaries', Medical care, vol. 56, no. 3, pp. 240-246.
Shen, C, Dasari, A, Gu, D, Chu, Y, Zhou, S, Xu, Y, Halperin, D, Fu, S, Yao, JC & Shih, YCT 2018, 'Costs of Cancer Care for Elderly Patients with Neuroendocrine Tumors', PharmacoEconomics, vol. 36, no. 8, pp. 1005-1013.
Wiener, RC, Shen, C, Findley, P, Tan, X & Sambamoorthi, U 2018, 'Dental Fluorosis over Time: A comparison of National Health and Nutrition Examination Survey data from 2001-2002 and 2011-2012', Journal of dental hygiene : JDH, vol. 92, no. 1, pp. 23-29.
Wiener, RC, Shen, C, Findley, PA, Dwibedi, N & Sambamoorthi, U 2018, 'Depressive symptoms and untreated coronal dental caries among adults ages 21-64 years, NHANES 2013-2014', Community dental health, vol. 35, no. 3, pp. 179-185.
Wiener, RC, Sambamoorthi, U, Shen, C, Alwhaibi, M & Findley, P 2018, 'Food Security and Unmet Dental Care Needs in Adults in the United States', Journal of dental hygiene : JDH, vol. 92, no. 3, pp. 14-22.
Roman-Gonzalez, A, Zhou, S, Ayala-Ramirez, M, Shen, C, Waguespack, SG, Habra, MA, Karam, JA, Perrier, N, Wood, CG & Jimenez, C 2018, 'Impact of Surgical Resection of the Primary Tumor on Overall Survival in Patients with Metastatic Pheochromocytoma or Sympathetic Paraganglioma', Annals of surgery, vol. 268, no. 1, pp. 172-178.
Nili, M, Shen, C & Sambamoorthi, U 2020, 'Low-value care: antipsychotic medication use among community-dwelling medicare beneficiaries with Alzheimer’s disease and related dementias and without severe mental illness', Aging and Mental Health, vol. 24, no. 3, pp. 504-510.
Shen, C, Zhao, X, Dwibedi, N, Wiener, RC, Findley, PA & Sambamoorthi, U 2018, 'Opioid use and the presence of Alzheimer's disease and related dementias among elderly Medicare beneficiaries diagnosed with chronic pain conditions', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 4, pp. 661-668.
Shen, C, Dasari, A, Xu, Y, Zhou, S, Gu, D, Chu, Y, Halperin, DM, Shih, YT & Yao, JC 2018, 'Pre-existing Symptoms and Healthcare Utilization Prior to Diagnosis of Neuroendocrine Tumors: A SEER-Medicare Database Study', Scientific reports, vol. 8, no. 1, 16863.
Liu, W, Chen, J, Tamayo, AT, Ruan, C, Li, L, Zhou, S, Shen, C, Young, KH, Westin, J, Davis, RE, Hu, S, Medeiros, LJ, Ford, RJ & Pham, LV 2018, 'Preclinical efficacy and biological effects of the oral proteasome inhibitor ixazomib in diffuse large B-cell lymphoma', Oncotarget, vol. 9, no. 1, pp. 346-360.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)