Researcher Profile

Researcher Profile

Xiaojun Lian

Xiaojun Lian

Associate Professor, Biomedical Engineering
Center for Neural Engineering
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Pluripotent Stem Cells
  • Cardiac Myocytes
  • Heart
  • Catenins
  • Stem Cells
  • In Vitro Techniques
  • Human Embryonic Stem Cells
  • Endothelial Cells
  • Gene Editing
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Intercellular Signaling Peptides and Proteins
  • Cell Differentiation

Recent Publications


Chang, Y, Syahirah, R, Oprescu, SN, Wang, X, Jung, J, Cooper, SH, Torregrosa-Allen, S, Elzey, BD, Hsu, AY, Randolph, LN, Sun, Y, Kuang, S, Broxmeyer, HE, Deng, Q, Lian, X & Bao, X 2022, 'Chemically-defined generation of human hemogenic endothelium and definitive hematopoietic progenitor cells', Biomaterials, vol. 285, 121569.
Jiang, Y, Hoenisch, RC, Chang, Y, Bao, X, Cameron, CE & Lian, XL 2022, 'Robust genome and RNA editing via CRISPR nucleases in PiggyBac systems', Bioactive Materials, vol. 14, pp. 313-320.


Jiang, Y, Bao, X & Lian, XL 2021, 'A dual cardiomyocyte reporter model derived from human pluripotent stem cells', Stem Cell Research and Therapy, vol. 12, no. 1, 305.
Nouri, R, Jiang, Y, Tang, Z, Lian, XL & Guan, W 2021, 'Detection of SARS-CoV-2 with Solid-State CRISPR-Cas12a-Assisted Nanopores', Nano letters, vol. 21, no. 19, pp. 8393-8400.
Jiang, Y, Chen, C, Randolph, LN, Ye, S, Zhang, X, Bao, X & Lian, XL 2021, 'Generation of pancreatic progenitors from human pluripotent stem cells by small molecules', Stem Cell Reports, vol. 16, no. 9, pp. 2395-2409.
Zhu, J, Liu, S, Hu, Z, Zhang, X, Yi, N, Tang, K, Dexheimer, MG, Lian, X, Wang, Q, Yang, J, Gray, J & Cheng, H 2021, 'Laser-induced graphene non-enzymatic glucose sensors for on-body measurements', Biosensors and Bioelectronics, vol. 193, 113606.
Hellwarth, PB, Chang, Y, Das, A, Liang, PY, Lian, X, Repina, NA & Bao, X 2021, 'Optogenetic-mediated cardiovascular differentiation and patterning of human pluripotent stem cells', Advanced Genetics, vol. 2, no. 3, e202100011.


Zhao, N, Coyne, J, Abune, L, Shi, P, Lian, XL, Zhang, G & Wang, Y 2020, 'Exogenous Signaling Molecules Released from Aptamer-Functionalized Hydrogels Promote the Survival of Mesenchymal Stem Cell Spheroids', ACS Applied Materials and Interfaces, vol. 12, no. 22, pp. 24599-24610.
Chang, Y, Hellwarth, PB, Randolph, LN, Sun, Y, Xing, Y, Zhu, W, Lian, XL & Bao, X 2020, 'Fluorescent indicators for continuous and lineage-specific reporting of cell-cycle phases in human pluripotent stem cells', Biotechnology and bioengineering, vol. 117, no. 7, pp. 2177-2186.
Jiang, Y & Lian, XL 2020, 'Heart regeneration with human pluripotent stem cells: Prospects and challenges', Bioactive Materials, vol. 5, no. 1, pp. 74-81.
Kim, GB, Aragon-Sanabria, V, Randolph, L, Jiang, H, Reynolds, JA, Webb, BS, Madhankumar, A, Lian, X, Connor, JR, Yang, J & Dong, C 2020, 'High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma', Bioactive Materials, vol. 5, no. 3, pp. 624-635.
Nouri, R, Jiang, Y, Lian, XL & Guan, W 2020, 'Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)', ACS Sensors, vol. 5, no. 5, pp. 1273-1280.


Randolph, LN & Lian, XL 2019, 'Beyond Purple Hearts: A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs', Cell Stem Cell, vol. 24, no. 5, pp. 675-677.
Randolph, LN, Bao, X, Oddo, M & Lian, XL 2019, 'Sex-dependent VEGF expression underlies variations in human pluripotent stem cell to endothelial progenitor differentiation', Scientific reports, vol. 9, no. 1, 16696.


Jiang, Y, Zhou, Y, Bao, X, Chen, C, Randolph, LN, Du, J & Lian, XL 2018, 'An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells', iScience, vol. 9, pp. 27-35.
Randolph, LN, Witmer, EB & Lian, X 2018, Chapter 4: Directed differentiation of human pluripotent stem cells for therapeutic applications. in Frontiers in Nanobiomedical Research. Frontiers in Nanobiomedical Research, vol. 10, World Scientific Publishing Co. Pte Ltd, pp. 75-100.
Randolph, LN, Bhattacharyya, A & Lian, XL 2019, 'Human Beta Cells Generated from Pluripotent Stem Cells or Cellular Reprogramming for Curing Diabetes', Regenerative Engineering and Translational Medicine, vol. 5, no. 1, pp. 42-52.
Foo, KS, Lehtinen, ML, Leung, CY, Lian, X, Xu, J, Keung, W, Geng, L, Kolstad, TRS, Thams, S, Wong, AOT, Wong, N, Bylund, K, Zhou, C, He, X, Jin, SB, Clarke, J, Lendahl, U, Li, RA, Louch, WE & Chien, KR 2018, 'Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction', Molecular Therapy, vol. 26, no. 7, pp. 1644-1659.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)