Researcher Profile

Researcher Profile

Xiaojun Lian

Xiaojun Lian

Assistant Professor, Biomedical Engineering
Scientific Program:Mechanisms of Carcinogenesis
xul34@psu.edu

Research Interests

  • Pluripotent Stem Cells
  • Cardiac Myocytes
  • Catenins
  • Heart
  • Human Embryonic Stem Cells
  • Stem Cells
  • Endothelial Cells
  • Intercellular Signaling Peptides and Proteins
  • Cell Differentiation
  • Gene Editing
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • src-Family Kinases

Recent Publications

2020

Zhao, N, Coyne, J, Abune, L, Shi, P, Lian, XL, Zhang, G & Wang, Y 2020, 'Exogenous Signaling Molecules Released from Aptamer-Functionalized Hydrogels Promote the Survival of Mesenchymal Stem Cell Spheroids', ACS Applied Materials and Interfaces. https://doi.org/10.1021/acsami.0c05681
Chang, Y, Hellwarth, PB, Randolph, LN, Sun, Y, Xing, Y, Zhu, W, Lian, XL & Bao, X 2020, 'Fluorescent indicators for continuous and lineage-specific reporting of cell-cycle phases in human pluripotent stem cells', Biotechnology and bioengineering, vol. 117, no. 7, pp. 2177-2186. https://doi.org/10.1002/bit.27352
Jiang, Y & Lian, XL 2020, 'Heart regeneration with human pluripotent stem cells: Prospects and challenges', Bioactive Materials, vol. 5, no. 1, pp. 74-81. https://doi.org/10.1016/j.bioactmat.2020.01.003
Kim, GB, Aragon-Sanabria, V, Randolph, L, Jiang, H, Reynolds, JA, Webb, BS, Madhankumar, A, Lian, X, Connor, JR, Yang, J & Dong, C 2020, 'High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma', Bioactive Materials, vol. 5, no. 3, pp. 624-635. https://doi.org/10.1016/j.bioactmat.2020.04.011
Nouri, R, Jiang, Y, Lian, XL & Guan, W 2020, 'Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)', ACS Sensors, vol. 5, no. 5, pp. 1273-1280. https://doi.org/10.1021/acssensors.0c00497

2019

Randolph, LN & Lian, XL 2019, 'Beyond Purple Hearts: A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs', Cell Stem Cell, vol. 24, no. 5, pp. 675-677. https://doi.org/10.1016/j.stem.2019.04.003
Randolph, LN, Bao, X, Oddo, M & Lian, XL 2019, 'Sex-dependent VEGF expression underlies variations in human pluripotent stem cell to endothelial progenitor differentiation', Scientific reports, vol. 9, no. 1, 16696. https://doi.org/10.1038/s41598-019-53054-z

2018

Foo, KS, Lehtinen, ML, Leung, CY, Lian, X, Xu, J, Keung, W, Geng, L, Kolstad, TRS, Thams, S, Wong, AOT, Wong, N, Bylund, K, Zhou, C, He, X, Jin, SB, Clarke, J, Lendahl, U, Li, RA, Louch, WE & Chien, KR 2018, ' Human ISL1 + Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction ', Molecular Therapy, vol. 26, no. 7, pp. 1644-1659. https://doi.org/10.1016/j.ymthe.2018.02.012
Jiang, Y, Zhou, Y, Bao, X, Chen, C, Randolph, LN, Du, J & Lian, XL 2018, 'An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells', iScience, vol. 9, pp. 27-35. https://doi.org/10.1016/j.isci.2018.10.007
Randolph, LN, Witmer, EB & Lian, X 2018, Chapter 4: Directed differentiation of human pluripotent stem cells for therapeutic applications. in Frontiers in Nanobiomedical Research. Frontiers in Nanobiomedical Research, vol. 10, World Scientific Publishing Co. Pte Ltd, pp. 75-100.
Randolph, LN, Bhattacharyya, A & Lian, XL 2019, 'Human Beta Cells Generated from Pluripotent Stem Cells or Cellular Reprogramming for Curing Diabetes', Regenerative Engineering and Translational Medicine, vol. 5, no. 1, pp. 42-52. https://doi.org/10.1007/s40883-018-0082-y

2017

Randolph, LN, Bao, X, Zhou, C & Lian, X 2017, 'An all-in-one, Tet-On 3G inducible PiggyBac system for human pluripotent stem cells and derivatives', Scientific reports, vol. 7, no. 1, 1549. https://doi.org/10.1038/s41598-017-01684-6
Bao, X, Lian, X, Qian, T, Bhute, VJ, Han, T & Palecek, SP 2017, 'Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions', Nature Protocols, vol. 12, no. 9, pp. 1890-1900. https://doi.org/10.1038/nprot.2017.080
Randolph, LN, Witmer, EB & Lian, X 2017, Directed differentiation of human pluripotent stem cells for therapeutic applications. in Tissue Engineering and Nanotheranostics. World Scientific Publishing Co. Pte Ltd, pp. 75-100. https://doi.org/10.1142/9789813149199_0004
Bao, X, Lian, X, Hacker, TA, Schmuck, EG, Qian, T, Bhute, VJ, Han, T, Shi, M, Drowley, L, Plowright, AT, Wang, QD, Goumans, MJ & Palecek, SP 2017, 'Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions', Nature Biomedical Engineering, vol. 1, no. 1, 0003. https://doi.org/10.1038/s41551-016-0003

2016

Bao, X, Lian, X & Palecek, SP 2016, Directed endothelial progenitor differentiation from human pluripotent stem cells via wnt activation under defined conditions. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1481, Humana Press Inc., pp. 183-196. https://doi.org/10.1007/978-1-4939-6393-5_17
Soh, BS, Ng, SY, Wu, H, Buac, K, Park, JHC, Lian, X, Xu, J, Foo, KS, Felldin, U, He, X, Nichane, M, Yang, H, Bu, L, Li, RA, Lim, B & Chien, KR 2016, 'Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells', Nature communications, vol. 7, 10774. https://doi.org/10.1038/ncomms10774
Hsiao, C, Lampe, M, Nillasithanukroh, S, Han, W, Lian, X & Palecek, SP 2016, 'Human pluripotent stem cell culture density modulates YAP signaling', Biotechnology Journal, vol. 11, no. 5, pp. 662-675. https://doi.org/10.1002/biot.201500374
Lian, X, Xu, J, Bao, X & Randolph, LN 2016, 'Interrogating Canonical Wnt Signaling Pathway in Human Pluripotent Stem Cell Fate Decisions Using CRISPR-Cas9', Cellular and Molecular Bioengineering, vol. 9, no. 3, pp. 325-334. https://doi.org/10.1007/s12195-016-0453-8
Braune, EB, Tsoi, YL, Phoon, YP, Landor, S, Silva Cascales, H, Ramsk├Âld, D, Deng, Q, Lindqvist, A, Lian, X, Sahlgren, C, Jin, SB & Lendahl, U 2016, 'Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells', Stem Cell Reports, vol. 6, no. 5, pp. 643-651. https://doi.org/10.1016/j.stemcr.2016.03.004

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)