Researcher Profile

Researcher Profile

Xiaojun Lian

Xiaojun Lian

Associate Professor, Biomedical Engineering
Center for Neural Engineering
Scientific Program:Mechanisms of Carcinogenesis
xul34@psu.edu

Research Interests

  • Pluripotent Stem Cells
  • Cardiac Myocytes
  • Heart
  • Catenins
  • Stem Cells
  • In Vitro Techniques
  • Human Embryonic Stem Cells
  • Endothelial Cells
  • Gene Editing
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Intercellular Signaling Peptides and Proteins
  • Cell Differentiation

Recent Publications

2022

Chang, Y, Syahirah, R, Oprescu, SN, Wang, X, Jung, J, Cooper, SH, Torregrosa-Allen, S, Elzey, BD, Hsu, AY, Randolph, LN, Sun, Y, Kuang, S, Broxmeyer, HE, Deng, Q, Lian, X & Bao, X 2022, 'Chemically-defined generation of human hemogenic endothelium and definitive hematopoietic progenitor cells', Biomaterials, vol. 285, 121569. https://doi.org/10.1016/j.biomaterials.2022.121569
Jiang, Y, Hoenisch, RC, Chang, Y, Bao, X, Cameron, CE & Lian, XL 2022, 'Robust genome and RNA editing via CRISPR nucleases in PiggyBac systems', Bioactive Materials, vol. 14, pp. 313-320. https://doi.org/10.1016/j.bioactmat.2022.01.046

2021

Jiang, Y, Bao, X & Lian, XL 2021, 'A dual cardiomyocyte reporter model derived from human pluripotent stem cells', Stem Cell Research and Therapy, vol. 12, no. 1, 305. https://doi.org/10.1186/s13287-021-02341-6
Nouri, R, Jiang, Y, Tang, Z, Lian, XL & Guan, W 2021, 'Detection of SARS-CoV-2 with Solid-State CRISPR-Cas12a-Assisted Nanopores', Nano letters, vol. 21, no. 19, pp. 8393-8400. https://doi.org/10.1021/acs.nanolett.1c02974
Jiang, Y, Chen, C, Randolph, LN, Ye, S, Zhang, X, Bao, X & Lian, XL 2021, 'Generation of pancreatic progenitors from human pluripotent stem cells by small molecules', Stem Cell Reports, vol. 16, no. 9, pp. 2395-2409. https://doi.org/10.1016/j.stemcr.2021.07.021
Zhu, J, Liu, S, Hu, Z, Zhang, X, Yi, N, Tang, K, Dexheimer, MG, Lian, X, Wang, Q, Yang, J, Gray, J & Cheng, H 2021, 'Laser-induced graphene non-enzymatic glucose sensors for on-body measurements', Biosensors and Bioelectronics, vol. 193, 113606. https://doi.org/10.1016/j.bios.2021.113606
Hellwarth, PB, Chang, Y, Das, A, Liang, PY, Lian, X, Repina, NA & Bao, X 2021, 'Optogenetic-mediated cardiovascular differentiation and patterning of human pluripotent stem cells', Advanced Genetics, vol. 2, no. 3, e202100011. https://doi.org/10.1002/ggn2.202100011

2020

Zhao, N, Coyne, J, Abune, L, Shi, P, Lian, XL, Zhang, G & Wang, Y 2020, 'Exogenous Signaling Molecules Released from Aptamer-Functionalized Hydrogels Promote the Survival of Mesenchymal Stem Cell Spheroids', ACS Applied Materials and Interfaces, vol. 12, no. 22, pp. 24599-24610. https://doi.org/10.1021/acsami.0c05681
Chang, Y, Hellwarth, PB, Randolph, LN, Sun, Y, Xing, Y, Zhu, W, Lian, XL & Bao, X 2020, 'Fluorescent indicators for continuous and lineage-specific reporting of cell-cycle phases in human pluripotent stem cells', Biotechnology and bioengineering, vol. 117, no. 7, pp. 2177-2186. https://doi.org/10.1002/bit.27352
Jiang, Y & Lian, XL 2020, 'Heart regeneration with human pluripotent stem cells: Prospects and challenges', Bioactive Materials, vol. 5, no. 1, pp. 74-81. https://doi.org/10.1016/j.bioactmat.2020.01.003
Kim, GB, Aragon-Sanabria, V, Randolph, L, Jiang, H, Reynolds, JA, Webb, BS, Madhankumar, A, Lian, X, Connor, JR, Yang, J & Dong, C 2020, 'High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma', Bioactive Materials, vol. 5, no. 3, pp. 624-635. https://doi.org/10.1016/j.bioactmat.2020.04.011
Nouri, R, Jiang, Y, Lian, XL & Guan, W 2020, 'Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)', ACS Sensors, vol. 5, no. 5, pp. 1273-1280. https://doi.org/10.1021/acssensors.0c00497

2019

Randolph, LN & Lian, XL 2019, 'Beyond Purple Hearts: A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs', Cell Stem Cell, vol. 24, no. 5, pp. 675-677. https://doi.org/10.1016/j.stem.2019.04.003
Randolph, LN, Bao, X, Oddo, M & Lian, XL 2019, 'Sex-dependent VEGF expression underlies variations in human pluripotent stem cell to endothelial progenitor differentiation', Scientific reports, vol. 9, no. 1, 16696. https://doi.org/10.1038/s41598-019-53054-z

2018

Jiang, Y, Zhou, Y, Bao, X, Chen, C, Randolph, LN, Du, J & Lian, XL 2018, 'An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells', iScience, vol. 9, pp. 27-35. https://doi.org/10.1016/j.isci.2018.10.007
Randolph, LN, Witmer, EB & Lian, X 2018, Chapter 4: Directed differentiation of human pluripotent stem cells for therapeutic applications. in Frontiers in Nanobiomedical Research. Frontiers in Nanobiomedical Research, vol. 10, World Scientific Publishing Co. Pte Ltd, pp. 75-100.
Randolph, LN, Bhattacharyya, A & Lian, XL 2019, 'Human Beta Cells Generated from Pluripotent Stem Cells or Cellular Reprogramming for Curing Diabetes', Regenerative Engineering and Translational Medicine, vol. 5, no. 1, pp. 42-52. https://doi.org/10.1007/s40883-018-0082-y
Foo, KS, Lehtinen, ML, Leung, CY, Lian, X, Xu, J, Keung, W, Geng, L, Kolstad, TRS, Thams, S, Wong, AOT, Wong, N, Bylund, K, Zhou, C, He, X, Jin, SB, Clarke, J, Lendahl, U, Li, RA, Louch, WE & Chien, KR 2018, 'Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction', Molecular Therapy, vol. 26, no. 7, pp. 1644-1659. https://doi.org/10.1016/j.ymthe.2018.02.012

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)