Researcher Profile

Researcher Profile

Xiaojun Lian

Xiaojun Lian

Assistant Professor, Biomedical Engineering
Scientific Program:Mechanisms of Carcinogenesis
xul34@psu.edu

Research Interests

  • Pluripotent Stem Cells
  • Cardiac Myocytes
  • Therapeutics
  • Catenins
  • Stem Cells
  • Endothelial Cells
  • Intercellular Signaling Peptides and Proteins
  • Cell Line
  • Mechanics
  • src-Family Kinases
  • Epithelial Cells
  • Clustered Regularly Interspaced Short Palindromic Repeats

Recent Publications

2019

Randolph, LN & Lian, X 2019, 'Beyond Purple Hearts: A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs' Cell Stem Cell. https://doi.org/10.1016/j.stem.2019.04.003

2018

Foo, KS, Lehtinen, ML, Leung, CY, Lian, X, Xu, J, Keung, W, Geng, L, Kolstad, TRS, Thams, S, Wong, AOT, Wong, N, Bylund, K, Zhou, C, He, X, Jin, SB, Clarke, J, Lendahl, U, Li, RA, Louch, WE & Chien, KR 2018, ' Human ISL1 + Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction ', Molecular Therapy, vol. 26, no. 7, pp. 1644-1659. https://doi.org/10.1016/j.ymthe.2018.02.012
Jiang, Y, Zhou, Y, Bao, X, Chen, C, Randolph, LN, Du, J & Lian, X 2018, 'An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells', iScience, vol. 9, pp. 27-35. https://doi.org/10.1016/j.isci.2018.10.007
Randolph, LN, Witmer, EB & Lian, X 2018, Chapter 4: Directed differentiation of human pluripotent stem cells for therapeutic applications. in Frontiers in Nanobiomedical Research. vol. 10, Frontiers in Nanobiomedical Research, vol. 10, World Scientific Publishing Co. Pte Ltd, pp. 75-100.
Randolph, LN, Bhattacharyya, A & Lian, X 2018, 'Human Beta Cells Generated from Pluripotent Stem Cells or Cellular Reprogramming for Curing Diabetes', Regenerative Engineering and Translational Medicine. https://doi.org/10.1007/s40883-018-0082-y

2017

Randolph, LN, Bao, X, Zhou, C & Lian, X 2017, 'An all-in-one, Tet-On 3G inducible PiggyBac system for human pluripotent stem cells and derivatives', Scientific Reports, vol. 7, no. 1, 1549. https://doi.org/10.1038/s41598-017-01684-6
Bao, X, Lian, X, Qian, T, Bhute, VJ, Han, T & Palecek, SP 2017, 'Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions', Nature Protocols, vol. 12, no. 9, pp. 1890-1900. https://doi.org/10.1038/nprot.2017.080
Randolph, LN, Witmer, EB & Lian, X 2017, Directed differentiation of human pluripotent stem cells for therapeutic applications. in Tissue Engineering and Nanotheranostics. World Scientific Publishing Co. Pte Ltd, pp. 75-100. https://doi.org/10.1142/9789813149199_0004
Bao, X, Lian, X, Hacker, TA, Schmuck, EG, Qian, T, Bhute, VJ, Han, T, Shi, M, Drowley, L, Plowright, AT, Wang, QD, Goumans, MJ & Palecek, SP 2017, 'Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions', Nature Biomedical Engineering, vol. 1, no. 1, 0003. https://doi.org/10.1038/s41551-016-0003

2016

Bao, X, Lian, X & Palecek, SP 2016, Directed endothelial progenitor differentiation from human pluripotent stem cells via wnt activation under defined conditions. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1481, Humana Press Inc., pp. 183-196. https://doi.org/10.1007/978-1-4939-6393-5_17
Soh, BS, Ng, SY, Wu, H, Buac, K, Park, JHC, Lian, X, Xu, J, Foo, KS, Felldin, U, He, X, Nichane, M, Yang, H, Bu, L, Li, RA, Lim, B & Chien, KR 2016, 'Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells', Nature communications, vol. 7, 10774. https://doi.org/10.1038/ncomms10774
Hsiao, C, Lampe, M, Nillasithanukroh, S, Han, W, Lian, X & Palecek, SP 2016, 'Human pluripotent stem cell culture density modulates YAP signaling', Biotechnology Journal, vol. 11, no. 5, pp. 662-675. https://doi.org/10.1002/biot.201500374
Lian, X, Xu, J, Bao, X & Randolph, LN 2016, 'Interrogating Canonical Wnt Signaling Pathway in Human Pluripotent Stem Cell Fate Decisions Using CRISPR-Cas9', Cellular and Molecular Bioengineering, vol. 9, no. 3, pp. 325-334. https://doi.org/10.1007/s12195-016-0453-8
Braune, EB, Tsoi, YL, Phoon, YP, Landor, S, Silva Cascales, H, Ramsk├Âld, D, Deng, Q, Lindqvist, A, Lian, X, Sahlgren, C, Jin, SB & Lendahl, U 2016, 'Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells', Stem Cell Reports, vol. 6, no. 5, pp. 643-651. https://doi.org/10.1016/j.stemcr.2016.03.004

2015

Lian, X, Bao, X, Zilberter, M, Westman, M, Fisahn, A, Hsiao, C, Hazeltine, LB, Dunn, KK, Kamp, TJ & Palecek, SP 2015, 'Chemically defined, albumin-free human cardiomyocyte generation', Nature methods, vol. 12, no. 7, pp. 595-596. https://doi.org/10.1038/nmeth.3448
Bao, X, Lian, X, Dunn, KK, Shi, M, Han, T, Qian, T, Bhute, VJ, Canfield, SG & Palecek, SP 2015, 'Chemically-defined albumin-free differentiation of human pluripotent stem cells to endothelial progenitor cells' Stem Cell Research, vol. 15, no. 1, pp. 122-129. https://doi.org/10.1016/j.scr.2015.05.004
Lian, X, Bao, X, Al-Ahmad, A, Liu, J, Wu, Y, Dong, W, Dunn, KK, Shusta, EV & Palecek, SP 2015, 'Erratum: Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling (Stem Cell Reports (2014) 3 (804-816))' Stem Cell Reports, vol. 4, no. 1. https://doi.org/10.1016/j.stemcr.2014.12.011
Selekman, JA, Lian, X & Palecek, SP 2015, 'Generation of epithelial cell populations from human pluripotent stem cells using a small-molecule inhibitor of Src family kinases' Methods in Molecular Biology, vol. 1307, pp. 319-327. https://doi.org/10.1007/7651_2014_70

Clinical Trials Search


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