Researcher Profile

Researcher Profile

Xiaojun Lian

Xiaojun Lian

Assistant Professor, Biomedical Engineering
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Pluripotent Stem Cells
  • Cardiac Myocytes
  • Catenins
  • Heart
  • Human Embryonic Stem Cells
  • Stem Cells
  • Endothelial Cells
  • Intercellular Signaling Peptides and Proteins
  • Cell Differentiation
  • Gene Editing
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • src-Family Kinases

Recent Publications


Zhao, N, Coyne, J, Abune, L, Shi, P, Lian, XL, Zhang, G & Wang, Y 2020, 'Exogenous Signaling Molecules Released from Aptamer-Functionalized Hydrogels Promote the Survival of Mesenchymal Stem Cell Spheroids', ACS Applied Materials and Interfaces.
Chang, Y, Hellwarth, PB, Randolph, LN, Sun, Y, Xing, Y, Zhu, W, Lian, XL & Bao, X 2020, 'Fluorescent indicators for continuous and lineage-specific reporting of cell-cycle phases in human pluripotent stem cells', Biotechnology and bioengineering, vol. 117, no. 7, pp. 2177-2186.
Jiang, Y & Lian, XL 2020, 'Heart regeneration with human pluripotent stem cells: Prospects and challenges', Bioactive Materials, vol. 5, no. 1, pp. 74-81.
Kim, GB, Aragon-Sanabria, V, Randolph, L, Jiang, H, Reynolds, JA, Webb, BS, Madhankumar, A, Lian, X, Connor, JR, Yang, J & Dong, C 2020, 'High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma', Bioactive Materials, vol. 5, no. 3, pp. 624-635.
Nouri, R, Jiang, Y, Lian, XL & Guan, W 2020, 'Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)', ACS Sensors, vol. 5, no. 5, pp. 1273-1280.


Randolph, LN & Lian, XL 2019, 'Beyond Purple Hearts: A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs', Cell Stem Cell, vol. 24, no. 5, pp. 675-677.
Randolph, LN, Bao, X, Oddo, M & Lian, XL 2019, 'Sex-dependent VEGF expression underlies variations in human pluripotent stem cell to endothelial progenitor differentiation', Scientific reports, vol. 9, no. 1, 16696.


Foo, KS, Lehtinen, ML, Leung, CY, Lian, X, Xu, J, Keung, W, Geng, L, Kolstad, TRS, Thams, S, Wong, AOT, Wong, N, Bylund, K, Zhou, C, He, X, Jin, SB, Clarke, J, Lendahl, U, Li, RA, Louch, WE & Chien, KR 2018, ' Human ISL1 + Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction ', Molecular Therapy, vol. 26, no. 7, pp. 1644-1659.
Jiang, Y, Zhou, Y, Bao, X, Chen, C, Randolph, LN, Du, J & Lian, XL 2018, 'An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells', iScience, vol. 9, pp. 27-35.
Randolph, LN, Witmer, EB & Lian, X 2018, Chapter 4: Directed differentiation of human pluripotent stem cells for therapeutic applications. in Frontiers in Nanobiomedical Research. Frontiers in Nanobiomedical Research, vol. 10, World Scientific Publishing Co. Pte Ltd, pp. 75-100.
Randolph, LN, Bhattacharyya, A & Lian, XL 2019, 'Human Beta Cells Generated from Pluripotent Stem Cells or Cellular Reprogramming for Curing Diabetes', Regenerative Engineering and Translational Medicine, vol. 5, no. 1, pp. 42-52.


Randolph, LN, Bao, X, Zhou, C & Lian, X 2017, 'An all-in-one, Tet-On 3G inducible PiggyBac system for human pluripotent stem cells and derivatives', Scientific reports, vol. 7, no. 1, 1549.
Bao, X, Lian, X, Qian, T, Bhute, VJ, Han, T & Palecek, SP 2017, 'Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions', Nature Protocols, vol. 12, no. 9, pp. 1890-1900.
Randolph, LN, Witmer, EB & Lian, X 2017, Directed differentiation of human pluripotent stem cells for therapeutic applications. in Tissue Engineering and Nanotheranostics. World Scientific Publishing Co. Pte Ltd, pp. 75-100.
Bao, X, Lian, X, Hacker, TA, Schmuck, EG, Qian, T, Bhute, VJ, Han, T, Shi, M, Drowley, L, Plowright, AT, Wang, QD, Goumans, MJ & Palecek, SP 2017, 'Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions', Nature Biomedical Engineering, vol. 1, no. 1, 0003.


Bao, X, Lian, X & Palecek, SP 2016, Directed endothelial progenitor differentiation from human pluripotent stem cells via wnt activation under defined conditions. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1481, Humana Press Inc., pp. 183-196.
Soh, BS, Ng, SY, Wu, H, Buac, K, Park, JHC, Lian, X, Xu, J, Foo, KS, Felldin, U, He, X, Nichane, M, Yang, H, Bu, L, Li, RA, Lim, B & Chien, KR 2016, 'Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells', Nature communications, vol. 7, 10774.
Hsiao, C, Lampe, M, Nillasithanukroh, S, Han, W, Lian, X & Palecek, SP 2016, 'Human pluripotent stem cell culture density modulates YAP signaling', Biotechnology Journal, vol. 11, no. 5, pp. 662-675.
Lian, X, Xu, J, Bao, X & Randolph, LN 2016, 'Interrogating Canonical Wnt Signaling Pathway in Human Pluripotent Stem Cell Fate Decisions Using CRISPR-Cas9', Cellular and Molecular Bioengineering, vol. 9, no. 3, pp. 325-334.
Braune, EB, Tsoi, YL, Phoon, YP, Landor, S, Silva Cascales, H, Ramsk├Âld, D, Deng, Q, Lindqvist, A, Lian, X, Sahlgren, C, Jin, SB & Lendahl, U 2016, 'Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells', Stem Cell Reports, vol. 6, no. 5, pp. 643-651.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)