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Xiaojun Lian

Xiaojun Lian

Associate Professor, Biomedical Engineering
Center for Neural Engineering
Scientific Program:Mechanisms of Carcinogenesis
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Research Interests

  • Pluripotent Stem Cells
  • Cardiac Myocytes
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Heart
  • Catenins
  • Gene Editing
  • Stem Cells
  • Human Embryonic Stem Cells
  • Cell Differentiation
  • Endothelial Cells
  • Intercellular Signaling Peptides and Proteins
  • Human Development

Recent Publications


Howells, AR, Welch, PJ, Kim, J, Forest, CR, Shi, C & Lian, XL 2024, 'A drug-selectable acoustic reporter gene system for human cell ultrasound imaging', Bioengineering and Translational Medicine, vol. 9, no. 2, e10584.
Chang, Y, Cai, X, Syahirah, R, Yao, Y, Xu, Y, Jin, G, Bhute, VJ, Torregrosa-Allen, S, Elzey, BD, Won, YY, Deng, Q, Lian, XL, Wang, X, Eniola-Adefeso, O & Bao, X 2023, 'CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapy', Nature communications, vol. 14, no. 1, 2266.
Jung, J, Chang, Y, Jin, G, Deng, Q, Lian, XL & Bao, X 2023, 'Chemically defined generation of human definitive hematopoietic stem and progenitor cells', STAR Protocols, vol. 4, no. 1, 101953.
Wang, K, Liu, X, Lian, XL, Bao, X & Li, K 2023, 'Editorial: Bioengineered gene and cell therapy for treating cardiovascular diseases', Frontiers in Bioengineering and Biotechnology, vol. 11, 1250175.
Chang, Y, Hummel, SN, Watson, MN, Jin, G, Lian, XL & Bao, X 2023, 'Engineered Artificial Human Neutrophils Exhibit Mature Functional Performance', ACS Synthetic Biology, vol. 12, no. 8, pp. 2262-2270.
Chang, Y, Jin, G, Luo, W, Luo, Q, Jung, J, Hummel, SN, Torregrosa-Allen, S, Elzey, BD, Low, PS, Lian, XL & Bao, X 2023, 'Engineered human pluripotent stem cell-derived natural killer cells with PD-L1 responsive immunological memory for enhanced immunotherapeutic efficacy', Bioactive Materials, vol. 27, pp. 168-180.
Wang, O, Han, L, Lin, H, Tian, M, Zhang, S, Duan, B, Chung, S, Zhang, C, Lian, X, Wang, Y & Lei, Y 2023, 'Fabricating 3-dimensional human brown adipose microtissues for transplantation studies', Bioactive Materials, vol. 22, pp. 518-534.
Nouri, R, Jiang, Y, Politza, AJ, Liu, T, Greene, WH, Zhu, Y, Nunez, JJ, Lian, X & Guan, W 2023, 'STAMP-Based Digital CRISPR-Cas13a for Amplification-Free Quantification of HIV-1 Plasma Viral Loads', ACS nano, vol. 17, no. 11, pp. 10701-10712.


Chang, Y, Syahirah, R, Oprescu, SN, Wang, X, Jung, J, Cooper, SH, Torregrosa-Allen, S, Elzey, BD, Hsu, AY, Randolph, LN, Sun, Y, Kuang, S, Broxmeyer, HE, Deng, Q, Lian, X & Bao, X 2022, 'Chemically-defined generation of human hemogenic endothelium and definitive hematopoietic progenitor cells', Biomaterials, vol. 285, 121569.
Nouri, R, Jiang, Y, Politza, AJ, Lian, XL & Guan, W 2022, Digital CRISPR-based quantification of HIV-1. in 2022 IEEE Sensors, SENSORS 2022 - Conference Proceedings. Proceedings of IEEE Sensors, vol. 2022-October, Institute of Electrical and Electronics Engineers Inc., 2022 IEEE Sensors Conference, SENSORS 2022, Dallas, United States, 10/30/22.
Chang, Y, Syahirah, R, Wang, X, Jin, G, Torregrosa-Allen, S, Elzey, BD, Hummel, SN, Wang, T, Li, C, Lian, X, Deng, Q, Broxmeyer, HE & Bao, X 2022, 'Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy', Cell Reports, vol. 40, no. 3, 111128.
Jiang, Y, Hoenisch, RC, Chang, Y, Bao, X, Cameron, CE & Lian, XL 2022, 'Robust genome and RNA editing via CRISPR nucleases in PiggyBac systems', Bioactive Materials, vol. 14, pp. 313-320.
Haideri, T, Howells, A, Jiang, Y, Yang, J, Bao, X & Lian, XL 2022, 'Robust genome editing via modRNA-based Cas9 or base editor in human pluripotent stem cells', Cell Reports Methods, vol. 2, no. 9, 100290.
Jung, J, Chang, Y, Jin, G, Lian, X & Bao, X 2022, 'Temporal Expression of Transcription Factor ID2 Improves Natural Killer Cell Differentiation from Human Pluripotent Stem Cells', ACS Synthetic Biology, vol. 11, no. 6, pp. 2001-2008.
Liang, PY, Chang, Y, Jin, G, Lian, X & Bao, X 2022, 'Wnt signaling directs human pluripotent stem cells into vascularized cardiac organoids with chamber-like structures', Frontiers in Bioengineering and Biotechnology, vol. 10, 1059243.


Jiang, Y, Bao, X & Lian, XL 2021, 'A dual cardiomyocyte reporter model derived from human pluripotent stem cells', Stem Cell Research and Therapy, vol. 12, no. 1, 305.
Nouri, R, Jiang, Y, Tang, Z, Lian, XL & Guan, W 2021, 'Detection of SARS-CoV-2 with Solid-State CRISPR-Cas12a-Assisted Nanopores', Nano letters, vol. 21, no. 19, pp. 8393-8400.
Jiang, Y, Chen, C, Randolph, LN, Ye, S, Zhang, X, Bao, X & Lian, XL 2021, 'Generation of pancreatic progenitors from human pluripotent stem cells by small molecules', Stem Cell Reports, vol. 16, no. 9, pp. 2395-2409.
Zhu, J, Liu, S, Hu, Z, Zhang, X, Yi, N, Tang, K, Dexheimer, MG, Lian, X, Wang, Q, Yang, J, Gray, J & Cheng, H 2021, 'Laser-induced graphene non-enzymatic glucose sensors for on-body measurements', Biosensors and Bioelectronics, vol. 193, 113606.
Hellwarth, PB, Chang, Y, Das, A, Liang, PY, Lian, X, Repina, NA & Bao, X 2021, 'Optogenetic-mediated cardiovascular differentiation and patterning of human pluripotent stem cells', Advanced Genetics, vol. 2, no. 3, e202100011.
Nouri, R, Jiang, Y, Tang, Z, Lian, XL & Guan, W 2021, Sequence-Specific Recognition of SARS COV-2 with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN). in MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society, pp. 833-834, 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021, Palm Springs, Virtual, United States, 10/10/21.


Zhao, N, Coyne, J, Abune, L, Shi, P, Lian, XL, Zhang, G & Wang, Y 2020, 'Exogenous Signaling Molecules Released from Aptamer-Functionalized Hydrogels Promote the Survival of Mesenchymal Stem Cell Spheroids', ACS Applied Materials and Interfaces, vol. 12, no. 22, pp. 24599-24610.
Chang, Y, Hellwarth, PB, Randolph, LN, Sun, Y, Xing, Y, Zhu, W, Lian, XL & Bao, X 2020, 'Fluorescent indicators for continuous and lineage-specific reporting of cell-cycle phases in human pluripotent stem cells', Biotechnology and bioengineering, vol. 117, no. 7, pp. 2177-2186.
Jiang, Y & Lian, XL 2020, 'Heart regeneration with human pluripotent stem cells: Prospects and challenges', Bioactive Materials, vol. 5, no. 1, pp. 74-81.
Kim, GB, Aragon-Sanabria, V, Randolph, L, Jiang, H, Reynolds, JA, Webb, BS, Madhankumar, A, Lian, X, Connor, JR, Yang, J & Dong, C 2020, 'High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma', Bioactive Materials, vol. 5, no. 3, pp. 624-635.
Nouri, R, Jiang, Y, Lian, XL & Guan, W 2020, 'Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)', ACS Sensors, vol. 5, no. 5, pp. 1273-1280.