Researcher Profile

Researcher Profile

Xiaojun Lian

Xiaojun Lian

Assistant Professor, Biomedical Engineering
Center for Neural Engineering
Scientific Program:Mechanisms of Carcinogenesis
xul34@psu.edu

Research Interests

  • Pluripotent Stem Cells
  • Cardiac Myocytes
  • Heart
  • Catenins
  • Human Embryonic Stem Cells
  • Stem Cells
  • Endothelial Cells
  • Intercellular Signaling Peptides and Proteins
  • Cell Differentiation
  • Gene Editing
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Infarction

Recent Publications

2020

Zhao, N, Coyne, J, Abune, L, Shi, P, Lian, XL, Zhang, G & Wang, Y 2020, 'Exogenous Signaling Molecules Released from Aptamer-Functionalized Hydrogels Promote the Survival of Mesenchymal Stem Cell Spheroids', ACS Applied Materials and Interfaces, vol. 12, no. 22, pp. 24599-24610. https://doi.org/10.1021/acsami.0c05681
Chang, Y, Hellwarth, PB, Randolph, LN, Sun, Y, Xing, Y, Zhu, W, Lian, XL & Bao, X 2020, 'Fluorescent indicators for continuous and lineage-specific reporting of cell-cycle phases in human pluripotent stem cells', Biotechnology and bioengineering, vol. 117, no. 7, pp. 2177-2186. https://doi.org/10.1002/bit.27352
Jiang, Y & Lian, XL 2020, 'Heart regeneration with human pluripotent stem cells: Prospects and challenges', Bioactive Materials, vol. 5, no. 1, pp. 74-81. https://doi.org/10.1016/j.bioactmat.2020.01.003
Kim, GB, Aragon-Sanabria, V, Randolph, L, Jiang, H, Reynolds, JA, Webb, BS, Madhankumar, A, Lian, X, Connor, JR, Yang, J & Dong, C 2020, 'High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma', Bioactive Materials, vol. 5, no. 3, pp. 624-635. https://doi.org/10.1016/j.bioactmat.2020.04.011
Nouri, R, Jiang, Y, Lian, XL & Guan, W 2020, 'Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)', ACS Sensors, vol. 5, no. 5, pp. 1273-1280. https://doi.org/10.1021/acssensors.0c00497

2019

Randolph, LN & Lian, XL 2019, 'Beyond Purple Hearts: A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs', Cell Stem Cell, vol. 24, no. 5, pp. 675-677. https://doi.org/10.1016/j.stem.2019.04.003
Randolph, LN, Bao, X, Oddo, M & Lian, XL 2019, 'Sex-dependent VEGF expression underlies variations in human pluripotent stem cell to endothelial progenitor differentiation', Scientific reports, vol. 9, no. 1, 16696. https://doi.org/10.1038/s41598-019-53054-z

2018

Jiang, Y, Zhou, Y, Bao, X, Chen, C, Randolph, LN, Du, J & Lian, XL 2018, 'An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells', iScience, vol. 9, pp. 27-35. https://doi.org/10.1016/j.isci.2018.10.007
Randolph, LN, Witmer, EB & Lian, X 2018, Chapter 4: Directed differentiation of human pluripotent stem cells for therapeutic applications. in Frontiers in Nanobiomedical Research. Frontiers in Nanobiomedical Research, vol. 10, World Scientific Publishing Co. Pte Ltd, pp. 75-100.
Randolph, LN, Bhattacharyya, A & Lian, XL 2019, 'Human Beta Cells Generated from Pluripotent Stem Cells or Cellular Reprogramming for Curing Diabetes', Regenerative Engineering and Translational Medicine, vol. 5, no. 1, pp. 42-52. https://doi.org/10.1007/s40883-018-0082-y
Foo, KS, Lehtinen, ML, Leung, CY, Lian, X, Xu, J, Keung, W, Geng, L, Kolstad, TRS, Thams, S, Wong, AOT, Wong, N, Bylund, K, Zhou, C, He, X, Jin, SB, Clarke, J, Lendahl, U, Li, RA, Louch, WE & Chien, KR 2018, 'Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction', Molecular Therapy, vol. 26, no. 7, pp. 1644-1659. https://doi.org/10.1016/j.ymthe.2018.02.012

2017

Randolph, LN, Bao, X, Zhou, C & Lian, X 2017, 'An all-in-one, Tet-On 3G inducible PiggyBac system for human pluripotent stem cells and derivatives', Scientific reports, vol. 7, no. 1, 1549. https://doi.org/10.1038/s41598-017-01684-6
Bao, X, Lian, X, Qian, T, Bhute, VJ, Han, T & Palecek, SP 2017, 'Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions', Nature Protocols, vol. 12, no. 9, pp. 1890-1900. https://doi.org/10.1038/nprot.2017.080
Randolph, LN, Witmer, EB & Lian, X 2017, Directed differentiation of human pluripotent stem cells for therapeutic applications. in Tissue Engineering and Nanotheranostics. World Scientific Publishing Co. Pte Ltd, pp. 75-100. https://doi.org/10.1142/9789813149199_0004
Bao, X, Lian, X, Hacker, TA, Schmuck, EG, Qian, T, Bhute, VJ, Han, T, Shi, M, Drowley, L, Plowright, AT, Wang, QD, Goumans, MJ & Palecek, SP 2017, 'Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions', Nature Biomedical Engineering, vol. 1, no. 1, 0003. https://doi.org/10.1038/s41551-016-0003

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)