Researcher Profile

Researcher Profile

Deb Kelly

Deb Kelly

Professor and Huck Chair in Molecular Biophysics, Biomedical Engineering
Scientific Program:Next-Generation Therapies
dfk5267@psu.edu

Research Interests

Dr. Deb Kelly's research focuses on innovative approaches to study biological systems, ranging from human viruses to cancer. Central to her work is high-resolution imaging, primarily cryo-Electron Microscopy (EM). Invasive breast cancer threatens the lives of women everywhere and there is no precise treatment for the disease. Her team has developed a tunable microchip toolkit to study mutations in the breast cancer susceptibility protein, BRCA1. Using this new tools, the Kelly lab expects to determine strategic insights for the molecular detection and prevention of BRCA1-related cancers. Her team is on the cutting edge of the burgeoning new field they call structural oncology.

  • Proteins
  • Electron Microscopy
  • Single Molecule Imaging
  • Cryoelectron Microscopy
  • Neoplasms
  • Lipids
  • Glioblastoma
  • Rotavirus
  • Electrons
  • Breast Neoplasms
  • Mutation
  • BRCA1 Protein

Recent Publications

2022

Jonaid, GM, Casasanta, MA, Dearnaley, WJ, Berry, S, Kaylor, L, Dressel-Dukes, MJ, Spilman, MS, Gray, JL & Kelly, DF 2022, 'Automated Tools to Advance High-Resolution Imaging in Liquid', Microscopy and Microanalysis, vol. 28, no. 2, pp. 361-370. https://doi.org/10.1017/S1431927621013921
Pridham, KJ, Shah, F, Hutchings, KR, Sheng, KL, Guo, S, Liu, M, Kanabur, P, Lamouille, S, Lewis, G, Morales, M, Jourdan, J, Grek, CL, Ghatnekar, GG, Varghese, R, Kelly, DF, Gourdie, RG & Sheng, Z 2022, 'Connexin 43 confers chemoresistance through activating PI3K', Oncogenesis, vol. 11, no. 1, 2. https://doi.org/10.1038/s41389-022-00378-7
Solares, MJ, Jonaid, GM, Luqiu, WY, Berry, S, Khadela, J, Liang, Y, Evans, MC, Pridham, KJ, Dearnaley, WJ, Sheng, Z & Kelly, D 2022, 'High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials', ChemBioChem. https://doi.org/10.1002/cbic.202200310

2021

Jonaid, GM, Dearnaley, WJ, Casasanta, MA, Kaylor, L, Berry, S, Dukes, MJ, Spilman, MS, Gray, JL & Kelly, DF 2021, 'High-Resolution Imaging of Human Viruses in Liquid Droplets', Advanced Materials, vol. 33, no. 37, 2103221. https://doi.org/10.1002/adma.202103221
Casasanta, MA, Jonaid, GM, Kaylor, L, Luqiu, WY, Solares, MJ, Schroen, ML, Dearnaley, WJ, Wilson, J, Dukes, MJ & Kelly, DF 2021, 'Microchip-based structure determination of low-molecular weight proteins using cryo-electron microscopy', Nanoscale, vol. 13, no. 15, pp. 7285-7293. https://doi.org/10.1039/d1nr00388g

2020

Dukes, M, Kelly, D & Varano, C 2020, 'Liquid cell TEM imaging techniques and optimization for biological samples', Microscopy and Microanalysis. https://doi.org/10.1017/S1431927620023788
Solares, MJ, Jonaid, GM, Luqiu, WY, Liang, Y, Evans, MC, Dearnaley, WJ, Sheng, Z & Kelly, DF 2020, 'Microchip-Based Structure Determination of Disease-Relevant p53', Analytical Chemistry, vol. 92, no. 23, pp. 15558-15564. https://doi.org/10.1021/acs.analchem.0c03599

2019

Liang, Y, Dearnaley, WJ, Alden, NA, Solares, MJ, Gilmore, BL, Pridham, KJ, Varano, C, Sheng, Z, Alli, E & Kelly, D 2019, 'Correcting errors in the BRCA1 warning system', DNA Repair, vol. 73, pp. 120-128. https://doi.org/10.1016/j.dnarep.2018.11.009
Hauser, M, Dearnaley, WJ, Varano, AC, Casasanta, M, McDonald, SM & Kelly, DF 2019, 'Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles', Computational and Structural Biotechnology Journal, vol. 17, pp. 1178-1183. https://doi.org/10.1016/j.csbj.2019.07.019
Alden, NA, Varano, AC, Dearnaley, WJ, Solares, MJ, Luqiu, WY, Liang, Y, Sheng, Z, McDonald, SM, Damiano, J, McConnell, J, Dukes, MJ & Kelly, DF 2019, 'Cryo-EM-On-a-Chip: Custom-Designed Substrates for the 3D Analysis of Macromolecules', Small, vol. 15, no. 21, 1900918. https://doi.org/10.1002/smll.201900918
Dearnaley, WJ, Schleupner, B, Varano, AC, Alden, NA, Gonzalez, F, Casasanta, MA, Scharf, BE, Dukes, MJ & Kelly, DF 2019, 'Liquid-Cell Electron Tomography of Biological Systems', Nano letters, vol. 19, no. 10, pp. 6734-6741. https://doi.org/10.1021/acs.nanolett.9b01309

2018

Varghese, RT, Young, S, Pham, L, Liang, Y, Pridham, KJ, Guo, S, Murphy, S, Kelly, DF & Sheng, Z 2018, 'Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival', Scientific reports, vol. 8, no. 1, 13621. https://doi.org/10.1038/s41598-018-31864-x
Pridham, KJ, Le, L, Guo, S, Varghese, RT, Algino, S, Liang, Y, Fajardin, R, Rodgers, CM, Simonds, GR, Kelly, DF & Sheng, Z 2018, 'PIK3CB/p110β is a selective survival factor for glioblastoma', Neuro-oncology, vol. 20, no. 4, pp. 494-505. https://doi.org/10.1093/neuonc/nox181
Gilmore, BL, Varano, AC, Dearnaley, W, Liang, Y, Marcinkowski, BC, Dukes, MJ & Kelly, DF 2018, Preparation of tunable microchips to visualize native protein complexes for single-particle electron microscopy. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1764, Humana Press Inc., pp. 45-58. https://doi.org/10.1007/978-1-4939-7759-8_3

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)