Researcher Profile

Researcher Profile

Deb Kelly

Deb Kelly

Professor and Huck Chair in Molecular Biophysics, Biomedical Engineering
Scientific Program:Experimental Therapeutics
dfk5267@psu.edu

Research Interests

Dr. Deb Kelly's research focuses on innovative approaches to study biological systems, ranging from human viruses to cancer. Central to her work is high-resolution imaging, primarily cryo-Electron Microscopy (EM). Invasive breast cancer threatens the lives of women everywhere and there is no precise treatment for the disease. Her team has developed a tunable microchip toolkit to study mutations in the breast cancer susceptibility protein, BRCA1. Using this new tools, the Kelly lab expects to determine strategic insights for the molecular detection and prevention of BRCA1-related cancers. Her team is on the cutting edge of the burgeoning new field they call structural oncology.

  • Proteins
  • Electron Microscopy
  • Cryoelectron Microscopy
  • Neoplasms
  • Lipids
  • Rotavirus
  • Glioblastoma
  • Therapeutics
  • Electrons
  • Breast Neoplasms
  • Mutation
  • BRCA1 Protein

Recent Publications

2019

Liang, Y, Dearnaley, WJ, Alden, NA, Solares, MJ, Gilmore, BL, Pridham, KJ, Varano, C, Sheng, Z, Alli, E & Kelly, D 2019, 'Correcting errors in the BRCA1 warning system' DNA Repair, vol. 73, pp. 120-128. https://doi.org/10.1016/j.dnarep.2018.11.009
Hauser, M, Dearnaley, WJ, Varano, C, Casasanta, M, McDonald, SM & Kelly, D 2019, 'Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles', Computational and Structural Biotechnology Journal, vol. 17, pp. 1178-1183. https://doi.org/10.1016/j.csbj.2019.07.019
Alden, NA, Varano, C, Dearnaley, WJ, Solares, MJ, Luqiu, WY, Liang, Y, Sheng, Z, McDonald, SM, Damiano, J, McConnell, J, Dukes, MJ & Kelly, D 2019, 'Cryo-EM-On-a-Chip: Custom-Designed Substrates for the 3D Analysis of Macromolecules', Small, vol. 15, no. 21, 1900918. https://doi.org/10.1002/smll.201900918
Dearnaley, WJ, Schleupner, B, Varano, C, Alden, NA, Gonzalez, F, Casasanta, MA, Scharf, BE, Dukes, MJ & Kelly, D 2019, 'Liquid-Cell Electron Tomography of Biological Systems', Nano letters. https://doi.org/10.1021/acs.nanolett.9b01309

2018

Varghese, RT, Young, S, Pham, L, Liang, Y, Pridham, KJ, Guo, S, Murphy, S, Kelly, D & Sheng, Z 2018, 'Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival', Scientific reports, vol. 8, no. 1, 13621. https://doi.org/10.1038/s41598-018-31864-x
Pridham, KJ, Le, L, Guo, S, Varghese, RT, Algino, S, Liang, Y, Fajardin, R, Rodgers, CM, Simonds, GR, Kelly, D & Sheng, Z 2018, 'PIK3CB/p110β is a selective survival factor for glioblastoma', Neuro-oncology, vol. 20, no. 4, pp. 494-505. https://doi.org/10.1093/neuonc/nox181
Gilmore, BL, Varano, C, Dearnaley, W, Liang, Y, Marcinkowski, BC, Dukes, MJ & Kelly, D 2018, Preparation of tunable microchips to visualize native protein complexes for single-particle electron microscopy. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1764, Humana Press Inc., pp. 45-58. https://doi.org/10.1007/978-1-4939-7759-8_3

2017

Gilmore, BL, Liang, Y, Winton, CE, Patel, K, Karageorge, V, Varano, C, Dearnaley, W, Sheng, Z & Kelly, D 2017, 'Molecular Analysis of BRCA1 in Human Breast Cancer Cells under Oxidative Stress', Scientific reports, vol. 7, 43435. https://doi.org/10.1038/srep43435
Cameron Varano, A, Harafuji, N, Dearnaley, W, Guay-Woodford, L & Kelly, D 2017, Preparation of disease-related protein assemblies for single particle electron microscopy. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1647, Humana Press Inc., pp. 185-196. https://doi.org/10.1007/978-1-4939-7201-2_12
DiMemmo, LM, Cameron Varano, A, Haulenbeek, J, Liang, Y, Patel, K, Dukes, MJ, Zheng, S, Hubert, M, Piccoli, SP & Kelly, D 2017, 'Real-time observation of protein aggregates in pharmaceutical formulations using liquid cell electron microscopy', Lab on a Chip, vol. 17, no. 2, pp. 315-322. https://doi.org/10.1039/C6LC01160H
Liang, Y, Dearnaley, WJ, Cameron Varano, A, Winton, CE, Gilmore, BL, Alden, NA, Sheng, Z & Kelly, D 2017, 'Structural analysis of BRCA1 reveals modification hotspot', Science Advances, vol. 3, no. 9, 1701386. https://doi.org/10.1126/sciadv.1701386

2016

Winton, CE, Gilmore, BL, Demmert, AC, Karageorge, V, Sheng, Z & Kelly, D 2016, 'A microchip platform for structural oncology applications', npj Breast Cancer, vol. 2, no. 1, 16016. https://doi.org/10.1038/npjbcancer.2016.16
Kanabur, P, Guo, S, Simonds, GR, Kelly, D, Gourdie, RG, Verbridge, SS & Sheng, Z 2016, 'Patient-derived glioblastoma stem cells respond differentially to targeted therapies', Oncotarget, vol. 7, no. 52, pp. 86406-86419. https://doi.org/10.18632/oncotarget.13415
Browning, CL, Qin, Q, Kelly, D, Prakash, R, Vanoli, F, Jasin, M & Wise, JP 2016, 'Prolonged particulate hexavalent chromium exposure suppresses homologous recombination repair in human lung cells', Toxicological Sciences, vol. 153, no. 1, pp. 70-78. https://doi.org/10.1093/toxsci/kfw103
Varghese, RT, Liang, Y, Guan, T, Franck, CT, Kelly, D & Sheng, Z 2016, 'Survival kinase genes present prognostic significance in glioblastoma', Oncotarget, vol. 7, no. 15, pp. 20140-20151. https://doi.org/10.18632/oncotarget.7917

2015

Gilmore, BL, Winton, CE, Demmert, AC, Tanner, JR, Bowman, S, Karageorge, V, Patel, K, Sheng, Z & Kelly, D 2015, 'A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease', Scientific reports, vol. 5, 14440. https://doi.org/10.1038/srep14440
Guo, S, Liang, Y, Murphy, SF, Huang, A, Shen, H, Kelly, D, Sobrado, P & Sheng, Z 2015, 'A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications', Autophagy, vol. 11, no. 3, pp. 560-572. https://doi.org/10.1080/15548627.2015.1017181
Boudreaux, CE, Kelly, D & McDonald, SM 2015, 'Electron microscopic analysis of rotavirus assembly-replication intermediates', Virology, vol. 477, pp. 32-41. https://doi.org/10.1016/j.virol.2015.01.003
Pohlmann, ES, Patel, K, Guo, S, Dukes, MJ, Sheng, Z & Kelly, D 2015, 'Real-Time Visualization of Nanoparticles Interacting with Glioblastoma Stem Cells' Nano Letters, vol. 15, no. 4, pp. 2329-2335. https://doi.org/10.1021/nl504481k
Delach, DL, Dukes, MJ, Varano, C, Kelly, D & Dukes, AD 2015, 'Real-time imaging of lead nanoparticles in solution-determination of the growth mechanism' RSC Advances, vol. 5, no. 126, pp. 104193-104197. https://doi.org/10.1039/c5ra18054f
Cameron Varano, A, Rahimi, A, Dukes, MJ, Poelzing, S, McDonald, SM & Kelly, D 2015, 'Visualizing virus particle mobility in liquid at the nanoscale', Chemical Communications, vol. 51, no. 90, pp. 16176-16179. https://doi.org/10.1039/c5cc05744b

Clinical Trials Search


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