Iryna Pinchuk, PhD - Penn State Cancer Institute
Researcher Profile
Iryna Pinchuk, PhD
Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Professor, Department of Cell and Biological Systems
Division of Gastroenterology and Hepatology
Professor, Department of Cell and Biological Systems
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2026
Yoo, JH, Choi, YJ, Pinchuk, IV, Powell, DW, Zachos, NC & Donowitz, M 2026, 'A model for Crohn’s disease post-ileal resection fibrosis development using human ileal enteroids and myofibroblasts', Frontiers in Physiology, vol. 17, 1764088. https://doi.org/10.3389/fphys.2026.1764088
Abomhya, A, Panganiban, R, Hassan, SA, Phinney, BB, McAninch, S, Yochum, G, Pinchuk, IV, Barrett, T & Beswick, EJ 2026, 'Distinct Serum and Tissue Markers Predict Fibrosis in Crohn’s Disease', Cells, vol. 15, no. 11, 1006. https://doi.org/10.3390/cells15111006
McAninch, C, Hahn, A, McAninch, S, Pinchuk, IV & Chulkina, M 2026, 'Protocol for establishing primary murine colonic fibroblast culture with induction of loxP/loxP deletion using transducible TAT-Cre recombinase', STAR Protocols, vol. 7, no. 1, 104330. https://doi.org/10.1016/j.xpro.2025.104330
2025
de Matos Guedes, HL, da Fonseca-Martins, AM, Liang, Y, Carlsen, ED, Henard, CA, Pinchuk, IV & Soong, L 2025, 'Leishmania amazonensis infection induces PD-L1 expression on dendritic cells and impairs Th1 responses in vitro and in vivo', Scientific reports, vol. 15, no. 1, 37856. https://doi.org/10.1038/s41598-025-21669-0
Howe, CS, Chulkina, M, McAninch, C, Syrcle, R, McAninch, S, Pinchuk, IV & Beswick, EJ 2025, 'MK2 Inhibition in CD4+T Cells Protects Against IFNγand IL-17A, Chronic Inflammation, and Fibrosis in Inflammatory Bowel Disease Models', Inflammatory bowel diseases, vol. 31, no. 6, pp. 1664-1676. https://doi.org/10.1093/ibd/izaf026
Lv, L, Maimaitiming, M, Xia, S, Yang, J, Zhang, T, Wang, Y, Li, X, Pinchuk, I, Wang, P, Wang, CY & Liu, Z 2025, 'MR2938 relieves DSS-induced colitis in mice through inhibiting NF-κB signaling and improving epithelial barrier', Marine Life Science and Technology, vol. 7, no. 4, pp. 915-924. https://doi.org/10.1007/s42995-025-00285-x
Chulkina, M, Tran, H, Uribe, G, McAninch, SB, McAninch, C, Seideneck, A, He, B, Lanza, M, Khanipov, K, Golovko, G, Powell, DW, Davenport, ER & Pinchuk, IV 2025, 'MyD88-mediated signaling in intestinal fibroblasts regulates macrophage antimicrobial defense and prevents dysbiosis in the gut', Cell Reports, vol. 44, no. 5, 115553. https://doi.org/10.1016/j.celrep.2025.115553
Ma, Z, McAninch, S, Liu, Z, Zhang, C, Chen, H, He, J, Yang, W, Panganiban, RP, Cong, Y, Yochum, G, Brasier, AR, Pinchuk, IV, Tian, B & Zhou, J 2025, 'Orally Bioavailable BRD4 BD1 Inhibitor ZL0516 Effectively Suppresses Colonic Inflammation in Animal Models of Inflammatory Bowel Disease', ACS Pharmacology and Translational Science, vol. 8, no. 4, pp. 1152-1167. https://doi.org/10.1021/acsptsci.5c00068
2024
Ma, Z, Bolinger, AA, Pinchuk, IV, Tian, B & Zhou, J 2024, BRD4 as an emerging epigenetic therapeutic target for inflammatory bowel disease. in FM Selaru & DE Peters (eds), Emerging Therapeutic Targets and Drug Delivery Approaches in IBD. Advances in Pharmacology, vol. 101, Academic Press Inc., pp. 203-236. https://doi.org/10.1016/bs.apha.2024.10.008
Arroyo Almenas, F, Törő, G, Szaniszlo, P, Maskey, M, Thanki, KK, Koltun, W, Yochum, GS, Pinchuk, IV, Chao, C, Hellmich, MR & Módis, K 2024, 'Cystathionine Gamma-Lyase Regulates TNF-α-Mediated Injury Response in Human Colonic Epithelial Cells and Colonoids', Antioxidants, vol. 13, no. 9, 1067. https://doi.org/10.3390/antiox13091067
Chulkina, M, Rohmer, C, McAninch, S, Panganiban, RP, Villéger, R, Portolese, A, Ciocirlan, J, Yang, W, Cohen, C, Koltun, W, Valentine, JF, Cong, Y, Yochum, G, Beswick, EJ & Pinchuk, IV 2024, 'Increased Activity of MAPKAPK2 within Mesenchymal Cells as a Target for Inflammation-Associated Fibrosis in Crohn's Disease', Journal of Crohn's and Colitis, vol. 18, no. 7, pp. 1147-1161. https://doi.org/10.1093/ecco-jcc/jjae009
Panganiban, RP, McAninch, C, Chulkina, M & Pinchuk, IV 2024, 'Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentials', Frontiers in Cell and Developmental Biology, vol. 12, 1452258. https://doi.org/10.3389/fcell.2024.1452258
2023
Villéger, R, Chulkina, M, Mifflin, RC, Powell, DW & Pinchuk, IV 2023, 'Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism', Oncotarget, vol. 14, no. 1, pp. 377-381. https://doi.org/10.18632/oncotarget.28399
Golovko, G, Khanipov, K, Reyes, V, Pinchuk, I & Fofanov, Y 2023, 'Identification of multivariable Boolean patterns in microbiome and microbial gene composition data', BioSystems, vol. 233, 105007. https://doi.org/10.1016/j.biosystems.2023.105007
Waldstein, S, Spengler, M, Pinchuk, IV & Yee, NS 2023, 'Impact of Colorectal Cancer Sidedness and Location on Therapy and Clinical Outcomes: Role of Blood-Based Biopsy for Personalized Treatment', Journal of Personalized Medicine, vol. 13, no. 7, 1114. https://doi.org/10.3390/jpm13071114
2022
Thanki, KK, Johnson, P, Higgins, EJ, Maskey, M, Phillips, CNN, Dash, S, Almenas, FA, Govar, AA, Tian, B, Villéger, R, Beswick, E, Wang, R, Szabo, C, Chao, C, Pinchuk, IV, Hellmich, MR & Módis, K 2022, 'Deletion of cystathionine-γ-lyase in bone marrow-derived cells promotes colitis-associated carcinogenesis', Redox Biology, vol. 55, 102417. https://doi.org/10.1016/j.redox.2022.102417
Pinchuk, I, Beswick, E & Das, S 2022, 'Editorial overview: Microbiome', Current Opinion in Physiology, vol. 25, 100481. https://doi.org/10.1016/j.cophys.2021.100481
Villéger, R, Chulkina, M, Mifflin, RC, Markov, NS, Trieu, J, Sinha, M, Johnson, P, Saada, JI, Adegboyega, PA, Luxon, BA, Beswick, EJ, Powell, DW & Pinchuk, IV 2023, 'Loss of alcohol dehydrogenase 1B in cancer-associated fibroblasts: contribution to the increase of tumor-promoting IL-6 in colon cancer', British Journal of Cancer, vol. 128, no. 4, pp. 537-548. https://doi.org/10.1038/s41416-022-02066-0
Zhao, X, Yang, W, Yu, T, Yu, Y, Cui, X, Zhou, Z, Yang, H, Yu, Y, Bilotta, AJ, Yao, S, Xu, J, Zhou, J, Yochum, GS, Koltun, WA, Portolese, A, Zeng, D, Xie, J, Pinchuk, IV, Zhang, H & Cong, Y 2023, 'Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts', Gastroenterology, vol. 164, no. 1, pp. 89-102. https://doi.org/10.1053/j.gastro.2022.09.006