Researcher Profile

Researcher Profile

Iryna Pinchuk, PhD

Iryna Pinchuk, PhD

Associate Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Scientific Program:Mechanisms of Carcinogenesis
ivp5097@psu.edu

Research Interests

  • Myofibroblasts
  • Helicobacter pylori
  • T-Lymphocytes
  • Stomach
  • Fibroblasts
  • Epithelial Cells
  • Inflammation
  • Stromal Cells
  • Neoplasms
  • Mucous Membrane
  • Helicobacter Infections
  • Cytokines

Recent Publications

2018

Beswick, EJ, Grim, C, Singh, A, Aguirre, JE, Tafoya, M, Qiu, S, Rogler, G, McKee, R, Samedi, V, Ma, T, Reyes, VE, Powell, DW & Pinchuk, I 2018, 'Expression of programmed death-ligand 1 by human colonic CD90+ stromal cells differs between ulcerative colitis and Crohn's disease and determines their capacity to suppress Th1 cells', Frontiers in immunology, vol. 9, no. MAY, 1125. https://doi.org/10.3389/fimmu.2018.01125
Pinchuk, I & Powell, DW 2018, Immunosuppression by intestinal stromal cells. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1060, Springer New York LLC, pp. 115-129. https://doi.org/10.1007/978-3-319-78127-3_7
Uribe, G, Villéger, R, Bressollier, P, Dillard, RN, Worthley, DL, Wang, TC, Powell, DW, Urdaci, MC & Pinchuk, I 2018, 'Lactobacillus rhamnosus GG increases cyclooxygenase-2 expression and prostaglandin E2 secretion in colonic myofibroblasts via a MyD88-dependent mechanism during homeostasis', Cellular Microbiology, vol. 20, no. 11, e12871. https://doi.org/10.1111/cmi.12871
Phinney, BB, Ray, AL, Peretti, AS, Jerman, SJ, Grim, C, Pinchuk, I & Beswick, EJ 2018, 'MK2 regulates macrophage chemokine activity and recruitment to promote colon tumor growth' Frontiers in immunology, vol. 9, no. SEP, 1857. https://doi.org/10.3389/fimmu.2018.01857

2017

Ijaz, T, Sun, H, Pinchuk, I, Milewicz, DM, Tilton, RG & Brasier, AR 2017, 'Deletion of NF-κB/RelA in angiotensin II-sensitive mesenchymal cells blocks aortic vascular inflammation and abdominal aortic aneurysm formation', Arteriosclerosis, thrombosis, and vascular biology, vol. 37, no. 10, pp. 1881-1890. https://doi.org/10.1161/ATVBAHA.117.309863
Falik Zaccai, TC, Savitzki, D, Zivony-Elboum, Y, Vilboux, T, Fitts, EC, Shoval, Y, Kalfon, L, Samra, N, Keren, Z, Gross, B, Chasnyk, N, Straussberg, R, Mullikin, JC, Teer, JK, Geiger, D, Kornitzer, D, Bitterman-Deutsch, O, Samson, AO, Wakamiya, M, Peterson, JW, Kirtley, ML, Pinchuk, I, Baze, WB, Gahl, WA, Kleta, R, Anikster, Y & Chopra, AK 2017, 'Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy', Brain, vol. 140, no. 2, pp. 370-386. https://doi.org/10.1093/brain/aww295

2016

Ray, AL, Castillo, EF, Morris, KT, Nofchissey, RA, Weston, LL, Samedi, VG, Hanson, JA, Gaestel, M, Pinchuk, I & Beswick, EJ 2016, 'Blockade of MK2 is protective in inflammation-associated colorectal cancer development', International Journal of Cancer, vol. 138, no. 3, pp. 770-775. https://doi.org/10.1002/ijc.29716
Huynh, PT, Beswick, EJ, Coronado, YA, Johnson, P, O'Connell, MR, Watts, T, Singh, P, Qiu, S, Morris, K, Powell, DW & Pinchuk, I 2016, 'CD90+ stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer', International Journal of Cancer, vol. 138, no. 8, pp. 1971-1981. https://doi.org/10.1002/ijc.29939
Johnson, P, Beswick, EJ, Chao, C, Powell, DW, Hellmich, MR & Pinchuk, I 2016, 'Isolation of CD 90+ fibroblast/myofibroblasts from human frozen gastrointestinal specimens', Journal of Visualized Experiments, vol. 2016, no. 107, e53691. https://doi.org/10.3791/53691
Watts, TL, Cui, R, Szaniszlo, P, Resto, VA, Powell, DW & Pinchuk, I 2016, 'PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment', Journal of Translational Medicine, vol. 14, no. 1, 337. https://doi.org/10.1186/s12967-016-1091-6
Snook, JD, Chesson, CB, Peniche, AG, Dann, SM, Paulucci, A, Pinchuk, I & Rudra, JS 2016, 'Peptide nanofiber-CaCO3 composite microparticles as adjuvant-free oral vaccine delivery vehicles', Journal of Materials Chemistry B, vol. 4, no. 9, pp. 1640-1649. https://doi.org/10.1039/c5tb01623a

2015

Morris, KT, Castillo, EF, Ray, AL, Weston, LL, Nofchissey, RA, Hanson, JA, Samedi, VG, Pinchuk, I, Hudson, LG & Beswick, EJ 2015, 'Anti-G-CSF treatment induces protective tumor immunity in mouse colon cancer by promoting NK cell, macrophage and T cell responses' Oncotarget, vol. 6, no. 26, pp. 22338-22347. https://doi.org/10.18632/oncotarget.4169
Lina, TT, Alzahrani, S, House, J, Yamaoka, Y, Sharpe, AH, Rampy, BA, Pinchuk, I & Reyes, VE 2015, 'Helicobacter pylori cag pathogenicity island's role in B7-H1 induction and immune evasion' PloS one, vol. 10, no. 3, e0121841. https://doi.org/10.1371/journal.pone.0121841
Wu, W, He, C, Liu, C, Cao, AT, Xue, X, Evans-Marin, HL, Sun, M, Fang, L, Yao, S, Pinchuk, I, Powell, DW, Liu, Z & Cong, Y 2015, 'miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD', Gut, vol. 64, no. 11, pp. 1755-1764. https://doi.org/10.1136/gutjnl-2014-307980

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)