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Iryna Pinchuk, PhD

Iryna Pinchuk, PhD

Associate Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Scientific Program:Mechanisms of Carcinogenesis
IVP5097@psu.edu

Research Interests

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Dr. Iryna Pinchuk's research focuses on the mechanisms responsible for the dysregulation of mucosal immune responses, in particular those that are involved in inflammatory bowel disease (IBD) and cancer.

Dr. Pinchuk has pioneered the understanding of the immune function of CD90+ stromal cells (CMFs) in colonic mucosa and demonstrated that in normal gastrointestinal mucosa, CMFs play an immunosuppressive role, contributing to the maintenance of the mucosal tolerance. Dr. Pinchuk also reported that IBD- and gastrointestinal-cancer-derived CMFs have altered tolerogenic function.

Her major study focus is to understand both the interplay between innate and adaptive cells during IBD and cancer development and progression as well as how microbiota modulate these interactions.

Dr. Pinchuk has substantial expertise in the area of human and rodent gastrointestinal mucosal immune responses and more than 15 years of experience in the areas of immunology, cell biology, microbiology and gastrointestinal research.

She holds a patent and has published numerous peer-reviewed articles and two book chapters in the field of immunology, cell biology and microbiology. 

  • Myofibroblasts
  • Helicobacter pylori
  • Stomach
  • Fibroblasts
  • T-Lymphocytes
  • Neoplasms
  • Inflammation
  • Epithelial Cells
  • Mucous Membrane
  • Colonic Neoplasms
  • Helicobacter Infections
  • Stromal Cells
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Recent Publications

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2023

Villéger, R, Chulkina, M, Mifflin, RC, Powell, DW & Pinchuk, IV 2023, 'Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism', Oncotarget, vol. 14, no. 1, pp. 377-381. https://doi.org/10.18632/oncotarget.28399
Golovko, G, Khanipov, K, Reyes, V, Pinchuk, I & Fofanov, Y 2023, 'Identification of multivariable Boolean patterns in microbiome and microbial gene composition data', BioSystems, vol. 233, 105007. https://doi.org/10.1016/j.biosystems.2023.105007
Waldstein, S, Spengler, M, Pinchuk, IV & Yee, NS 2023, 'Impact of Colorectal Cancer Sidedness and Location on Therapy and Clinical Outcomes: Role of Blood-Based Biopsy for Personalized Treatment', Journal of Personalized Medicine, vol. 13, no. 7, 1114. https://doi.org/10.3390/jpm13071114

2022

Thanki, KK, Johnson, P, Higgins, EJ, Maskey, M, Phillips, CNN, Dash, S, Almenas, FA, Govar, AA, Tian, B, Villéger, R, Beswick, E, Wang, R, Szabo, C, Chao, C, Pinchuk, IV, Hellmich, MR & Módis, K 2022, 'Deletion of cystathionine-γ-lyase in bone marrow-derived cells promotes colitis-associated carcinogenesis', Redox Biology, vol. 55, 102417. https://doi.org/10.1016/j.redox.2022.102417
Pinchuk, I, Beswick, E & Das, S 2022, 'Editorial overview: Microbiome', Current Opinion in Physiology, vol. 25, 100481. https://doi.org/10.1016/j.cophys.2021.100481
Villéger, R, Chulkina, M, Mifflin, RC, Markov, NS, Trieu, J, Sinha, M, Johnson, P, Saada, JI, Adegboyega, PA, Luxon, BA, Beswick, EJ, Powell, DW & Pinchuk, IV 2023, 'Loss of alcohol dehydrogenase 1B in cancer-associated fibroblasts: contribution to the increase of tumor-promoting IL-6 in colon cancer', British Journal of Cancer, vol. 128, no. 4, pp. 537-548. https://doi.org/10.1038/s41416-022-02066-0
Zhao, X, Yang, W, Yu, T, Yu, Y, Cui, X, Zhou, Z, Yang, H, Yu, Y, Bilotta, AJ, Yao, S, Xu, J, Zhou, J, Yochum, GS, Koltun, WA, Portolese, A, Zeng, D, Xie, J, Pinchuk, IV, Zhang, H & Cong, Y 2023, 'Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts', Gastroenterology, vol. 164, no. 1, pp. 89-102. https://doi.org/10.1053/j.gastro.2022.09.006

2021

Mohamed, A, Menon, H, Chulkina, M, Yee, NS & Pinchuk, IV 2021, 'Drug–microbiota interaction in colon cancer therapy: Impact of antibiotics', Biomedicines, vol. 9, no. 3, 259, pp. 1-13. https://doi.org/10.3390/biomedicines9030259
Grim, C, Noble, R, Uribe, G, Khanipov, K, Johnson, P, Koltun, WA, Watts, T, Fofanov, Y, Yochum, GS, Powell, DW, Beswick, EJ & Pinchuk, IV 2021, 'Impairment of Tissue-Resident Mesenchymal Stem Cells in Chronic Ulcerative Colitis and Crohn's Disease', Journal of Crohn's and Colitis, vol. 15, no. 8, pp. 1362-1375. https://doi.org/10.1093/ecco-jcc/jjab001
Li, Y, Chen, J, Bolinger, AA, Chen, H, Liu, Z, Cong, Y, Brasier, AR, Pinchuk, IV, Tian, B & Zhou, J 2021, 'Target-based small molecule drug discovery towards novel therapeutics for inflammatory bowel diseases', Inflammatory bowel diseases, vol. 27, pp. S38-S62. https://doi.org/10.1093/ibd/izab190

2020

Wang, J, Cui, R, Clement, CG, Nawgiri, R, Powell, DW, Pinchuk, IV & Watts, TL 2020, 'Activation PDGFR-α/AKT Mediated Signaling Pathways in Oral Squamous Cell Carcinoma by Mesenchymal Stem/Stromal Cells Promotes Anti-apoptosis and Decreased Sensitivity to Cisplatin', Frontiers in Oncology, vol. 10, 552. https://doi.org/10.3389/fonc.2020.00552
Petrey, AC, Qeadan, F, Middleton, EA, Pinchuk, IV, Campbell, RA & Beswick, EJ 2021, 'Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex', Journal of Leukocyte Biology, vol. 109, no. 1, pp. 55-66. https://doi.org/10.1002/JLB.3COVA0820-410RRR
Sayed, IM, Sahan, AZ, Venkova, T, Chakraborty, A, Mukhopadhyay, D, Bimczok, D, Beswick, EJ, Reyes, VE, Pinchuk, I, Sahoo, D, Ghosh, P, Hazra, TK & Das, S 2020, 'Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells', Journal of Biological Chemistry, vol. 295, no. 32, pp. 11082-11098. https://doi.org/10.1074/jbc.ra119.009981
Aguirre, JE, Beswick, EJ, Grim, C, Uribe, G, Tafoya, M, Palma, GC, Samedi, V, McKee, R, Villeger, R, Fofanov, Y, Cong, Y, Yochum, G, Koltun, W, Powell, D & Pinchuk, IV 2020, 'Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90+ (myo-)fibroblasts in Crohn’s disease and regulate Th1/Th17 cell responses', International immunology, vol. 32, no. 1, pp. 57-68. https://doi.org/10.1093/intimm/dxz060
Chulkina, M, Beswick, EJ & Pinchuk, IV 2020, 'Role of pd-l1 in gut mucosa tolerance and chronic inflammation', International journal of molecular sciences, vol. 21, no. 23, 9165, pp. 1-16. https://doi.org/10.3390/ijms21239165
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