Researcher Profile

Researcher Profile

Iryna Pinchuk, PhD

Iryna Pinchuk, PhD

Associate Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Myofibroblasts
  • Helicobacter pylori
  • T-Lymphocytes
  • Stomach
  • Fibroblasts
  • Epithelial Cells
  • Inflammation
  • Stromal Cells
  • Neoplasms
  • Mucous Membrane
  • Helicobacter Infections
  • Cytokines

Recent Publications


Beswick, EJ, Grim, C, Singh, A, Aguirre, JE, Tafoya, M, Qiu, S, Rogler, G, McKee, R, Samedi, V, Ma, T, Reyes, VE, Powell, DW & Pinchuk, I 2018, 'Expression of programmed death-ligand 1 by human colonic CD90+ stromal cells differs between ulcerative colitis and Crohn's disease and determines their capacity to suppress Th1 cells', Frontiers in immunology, vol. 9, no. MAY, 1125.
Pinchuk, I & Powell, DW 2018, Immunosuppression by intestinal stromal cells. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1060, Springer New York LLC, pp. 115-129.
Uribe, G, Villéger, R, Bressollier, P, Dillard, RN, Worthley, DL, Wang, TC, Powell, DW, Urdaci, MC & Pinchuk, I 2018, 'Lactobacillus rhamnosus GG increases cyclooxygenase-2 expression and prostaglandin E2 secretion in colonic myofibroblasts via a MyD88-dependent mechanism during homeostasis', Cellular Microbiology, vol. 20, no. 11, e12871.
Phinney, BB, Ray, AL, Peretti, AS, Jerman, SJ, Grim, C, Pinchuk, I & Beswick, EJ 2018, 'MK2 regulates macrophage chemokine activity and recruitment to promote colon tumor growth' Frontiers in immunology, vol. 9, no. SEP, 1857.


Ijaz, T, Sun, H, Pinchuk, I, Milewicz, DM, Tilton, RG & Brasier, AR 2017, 'Deletion of NF-κB/RelA in angiotensin II-sensitive mesenchymal cells blocks aortic vascular inflammation and abdominal aortic aneurysm formation', Arteriosclerosis, thrombosis, and vascular biology, vol. 37, no. 10, pp. 1881-1890.
Falik Zaccai, TC, Savitzki, D, Zivony-Elboum, Y, Vilboux, T, Fitts, EC, Shoval, Y, Kalfon, L, Samra, N, Keren, Z, Gross, B, Chasnyk, N, Straussberg, R, Mullikin, JC, Teer, JK, Geiger, D, Kornitzer, D, Bitterman-Deutsch, O, Samson, AO, Wakamiya, M, Peterson, JW, Kirtley, ML, Pinchuk, I, Baze, WB, Gahl, WA, Kleta, R, Anikster, Y & Chopra, AK 2017, 'Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy', Brain, vol. 140, no. 2, pp. 370-386.


Ray, AL, Castillo, EF, Morris, KT, Nofchissey, RA, Weston, LL, Samedi, VG, Hanson, JA, Gaestel, M, Pinchuk, I & Beswick, EJ 2016, 'Blockade of MK2 is protective in inflammation-associated colorectal cancer development', International Journal of Cancer, vol. 138, no. 3, pp. 770-775.
Huynh, PT, Beswick, EJ, Coronado, YA, Johnson, P, O'Connell, MR, Watts, T, Singh, P, Qiu, S, Morris, K, Powell, DW & Pinchuk, I 2016, 'CD90+ stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer', International Journal of Cancer, vol. 138, no. 8, pp. 1971-1981.
Johnson, P, Beswick, EJ, Chao, C, Powell, DW, Hellmich, MR & Pinchuk, I 2016, 'Isolation of CD 90+ fibroblast/myofibroblasts from human frozen gastrointestinal specimens', Journal of Visualized Experiments, vol. 2016, no. 107, e53691.
Watts, TL, Cui, R, Szaniszlo, P, Resto, VA, Powell, DW & Pinchuk, I 2016, 'PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment', Journal of Translational Medicine, vol. 14, no. 1, 337.
Snook, JD, Chesson, CB, Peniche, AG, Dann, SM, Paulucci, A, Pinchuk, I & Rudra, JS 2016, 'Peptide nanofiber-CaCO3 composite microparticles as adjuvant-free oral vaccine delivery vehicles', Journal of Materials Chemistry B, vol. 4, no. 9, pp. 1640-1649.


Morris, KT, Castillo, EF, Ray, AL, Weston, LL, Nofchissey, RA, Hanson, JA, Samedi, VG, Pinchuk, I, Hudson, LG & Beswick, EJ 2015, 'Anti-G-CSF treatment induces protective tumor immunity in mouse colon cancer by promoting NK cell, macrophage and T cell responses' Oncotarget, vol. 6, no. 26, pp. 22338-22347.
Lina, TT, Alzahrani, S, House, J, Yamaoka, Y, Sharpe, AH, Rampy, BA, Pinchuk, I & Reyes, VE 2015, 'Helicobacter pylori cag pathogenicity island's role in B7-H1 induction and immune evasion' PloS one, vol. 10, no. 3, e0121841.
Wu, W, He, C, Liu, C, Cao, AT, Xue, X, Evans-Marin, HL, Sun, M, Fang, L, Yao, S, Pinchuk, I, Powell, DW, Liu, Z & Cong, Y 2015, 'miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD', Gut, vol. 64, no. 11, pp. 1755-1764.

Clinical Trials Search

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