Researcher Profile

Researcher Profile

Iryna Pinchuk, PhD

Iryna Pinchuk, PhD

Associate Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Scientific Program:Mechanisms of Carcinogenesis
ivp5097@psu.edu

Research Interests

Dr. Iryna Pinchuk's research focuses on the mechanisms responsible for the dysregulation of mucosal immune responses, in particular those that are involved in inflammatory bowel disease (IBD) and cancer.

Dr. Pinchuk has pioneered the understanding of the immune function of CD90+ stromal cells (CMFs) in colonic mucosa and demonstrated that in normal gastrointestinal mucosa, CMFs play an immunosuppressive role, contributing to the maintenance of the mucosal tolerance. Dr. Pinchuk also reported that IBD- and gastrointestinal-cancer-derived CMFs have altered tolerogenic function.

Her major study focus is to understand both the interplay between innate and adaptive cells during IBD and cancer development and progression as well as how microbiota modulate these interactions.

Dr. Pinchuk has substantial expertise in the area of human and rodent gastrointestinal mucosal immune responses and more than 15 years of experience in the areas of immunology, cell biology, microbiology and gastrointestinal research.

She holds a patent and has published numerous peer-reviewed articles and two book chapters in the field of immunology, cell biology and microbiology. 

  • Myofibroblasts
  • Helicobacter pylori
  • T-Lymphocytes
  • Stomach
  • Fibroblasts
  • Epithelial Cells
  • Neoplasms
  • Stromal Cells
  • Inflammation
  • Mucous Membrane
  • Helicobacter Infections
  • Cytokines

Recent Publications

2018

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Pinchuk, I & Powell, DW 2018, Immunosuppression by intestinal stromal cells. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1060, Springer New York LLC, pp. 115-129. https://doi.org/10.1007/978-3-319-78127-3_7
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Phinney, BB, Ray, AL, Peretti, AS, Jerman, SJ, Grim, C, Pinchuk, I & Beswick, EJ 2018, 'MK2 regulates macrophage chemokine activity and recruitment to promote colon tumor growth', Frontiers in immunology, vol. 9, no. SEP, 1857. https://doi.org/10.3389/fimmu.2018.01857

2017

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2016

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2015

Morris, KT, Castillo, EF, Ray, AL, Weston, LL, Nofchissey, RA, Hanson, JA, Samedi, VG, Pinchuk, I, Hudson, LG & Beswick, EJ 2015, 'Anti-G-CSF treatment induces protective tumor immunity in mouse colon cancer by promoting NK cell, macrophage and T cell responses', Oncotarget, vol. 6, no. 26, pp. 22338-22347. https://doi.org/10.18632/oncotarget.4169
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