Iryna Pinchuk, PhD - Penn State Cancer Institute
Researcher Profile
Iryna Pinchuk, PhD
Associate Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Division of Gastroenterology and Hepatology
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2024
Ma, Z, Bolinger, AA, Pinchuk, IV, Tian, B & Zhou, J 2024, BRD4 as an emerging epigenetic therapeutic target for inflammatory bowel disease. in FM Selaru & DE Peters (eds), Emerging Therapeutic Targets and Drug Delivery Approaches in IBD. Advances in Pharmacology, vol. 101, Academic Press Inc., pp. 203-236. https://doi.org/10.1016/bs.apha.2024.10.008
Arroyo Almenas, F, Törő, G, Szaniszlo, P, Maskey, M, Thanki, KK, Koltun, W, Yochum, GS, Pinchuk, IV, Chao, C, Hellmich, MR & Módis, K 2024, 'Cystathionine Gamma-Lyase Regulates TNF-α-Mediated Injury Response in Human Colonic Epithelial Cells and Colonoids', Antioxidants, vol. 13, no. 9, 1067. https://doi.org/10.3390/antiox13091067
Chulkina, M, Rohmer, C, McAninch, S, Panganiban, RP, Villéger, R, Portolese, A, Ciocirlan, J, Yang, W, Cohen, C, Koltun, W, Valentine, JF, Cong, Y, Yochum, G, Beswick, EJ & Pinchuk, IV 2024, 'Increased Activity of MAPKAPK2 within Mesenchymal Cells as a Target for Inflammation-Associated Fibrosis in Crohn's Disease', Journal of Crohn's and Colitis, vol. 18, no. 7, pp. 1147-1161. https://doi.org/10.1093/ecco-jcc/jjae009
2023
Villéger, R, Chulkina, M, Mifflin, RC, Powell, DW & Pinchuk, IV 2023, 'Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism', Oncotarget, vol. 14, no. 1, pp. 377-381. https://doi.org/10.18632/oncotarget.28399
Golovko, G, Khanipov, K, Reyes, V, Pinchuk, I & Fofanov, Y 2023, 'Identification of multivariable Boolean patterns in microbiome and microbial gene composition data', BioSystems, vol. 233, 105007. https://doi.org/10.1016/j.biosystems.2023.105007
Waldstein, S, Spengler, M, Pinchuk, IV & Yee, NS 2023, 'Impact of Colorectal Cancer Sidedness and Location on Therapy and Clinical Outcomes: Role of Blood-Based Biopsy for Personalized Treatment', Journal of Personalized Medicine, vol. 13, no. 7, 1114. https://doi.org/10.3390/jpm13071114
2022
Thanki, KK, Johnson, P, Higgins, EJ, Maskey, M, Phillips, CNN, Dash, S, Almenas, FA, Govar, AA, Tian, B, Villéger, R, Beswick, E, Wang, R, Szabo, C, Chao, C, Pinchuk, IV, Hellmich, MR & Módis, K 2022, 'Deletion of cystathionine-γ-lyase in bone marrow-derived cells promotes colitis-associated carcinogenesis', Redox Biology, vol. 55, 102417. https://doi.org/10.1016/j.redox.2022.102417
Pinchuk, I, Beswick, E & Das, S 2022, 'Editorial overview: Microbiome', Current Opinion in Physiology, vol. 25, 100481. https://doi.org/10.1016/j.cophys.2021.100481
Villéger, R, Chulkina, M, Mifflin, RC, Markov, NS, Trieu, J, Sinha, M, Johnson, P, Saada, JI, Adegboyega, PA, Luxon, BA, Beswick, EJ, Powell, DW & Pinchuk, IV 2023, 'Loss of alcohol dehydrogenase 1B in cancer-associated fibroblasts: contribution to the increase of tumor-promoting IL-6 in colon cancer', British Journal of Cancer, vol. 128, no. 4, pp. 537-548. https://doi.org/10.1038/s41416-022-02066-0
Zhao, X, Yang, W, Yu, T, Yu, Y, Cui, X, Zhou, Z, Yang, H, Yu, Y, Bilotta, AJ, Yao, S, Xu, J, Zhou, J, Yochum, GS, Koltun, WA, Portolese, A, Zeng, D, Xie, J, Pinchuk, IV, Zhang, H & Cong, Y 2023, 'Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts', Gastroenterology, vol. 164, no. 1, pp. 89-102. https://doi.org/10.1053/j.gastro.2022.09.006
2021
Mohamed, A, Menon, H, Chulkina, M, Yee, NS & Pinchuk, IV 2021, 'Drug–microbiota interaction in colon cancer therapy: Impact of antibiotics', Biomedicines, vol. 9, no. 3, 259, pp. 1-13. https://doi.org/10.3390/biomedicines9030259
Grim, C, Noble, R, Uribe, G, Khanipov, K, Johnson, P, Koltun, WA, Watts, T, Fofanov, Y, Yochum, GS, Powell, DW, Beswick, EJ & Pinchuk, IV 2021, 'Impairment of Tissue-Resident Mesenchymal Stem Cells in Chronic Ulcerative Colitis and Crohn's Disease', Journal of Crohn's and Colitis, vol. 15, no. 8, pp. 1362-1375. https://doi.org/10.1093/ecco-jcc/jjab001
Li, Y, Chen, J, Bolinger, AA, Chen, H, Liu, Z, Cong, Y, Brasier, AR, Pinchuk, IV, Tian, B & Zhou, J 2021, 'Target-based small molecule drug discovery towards novel therapeutics for inflammatory bowel diseases', Inflammatory bowel diseases, vol. 27, pp. S38-S62. https://doi.org/10.1093/ibd/izab190
2020
Wang, J, Cui, R, Clement, CG, Nawgiri, R, Powell, DW, Pinchuk, IV & Watts, TL 2020, 'Activation PDGFR-α/AKT Mediated Signaling Pathways in Oral Squamous Cell Carcinoma by Mesenchymal Stem/Stromal Cells Promotes Anti-apoptosis and Decreased Sensitivity to Cisplatin', Frontiers in Oncology, vol. 10, 552. https://doi.org/10.3389/fonc.2020.00552
Petrey, AC, Qeadan, F, Middleton, EA, Pinchuk, IV, Campbell, RA & Beswick, EJ 2021, 'Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex', Journal of Leukocyte Biology, vol. 109, no. 1, pp. 55-66. https://doi.org/10.1002/JLB.3COVA0820-410RRR
Sayed, IM, Sahan, AZ, Venkova, T, Chakraborty, A, Mukhopadhyay, D, Bimczok, D, Beswick, EJ, Reyes, VE, Pinchuk, I, Sahoo, D, Ghosh, P, Hazra, TK & Das, S 2020, 'Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells', Journal of Biological Chemistry, vol. 295, no. 32, pp. 11082-11098. https://doi.org/10.1074/jbc.ra119.009981
Aguirre, JE, Beswick, EJ, Grim, C, Uribe, G, Tafoya, M, Palma, GC, Samedi, V, McKee, R, Villeger, R, Fofanov, Y, Cong, Y, Yochum, G, Koltun, W, Powell, D & Pinchuk, IV 2020, 'Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90+ (myo-)fibroblasts in Crohn’s disease and regulate Th1/Th17 cell responses', International immunology, vol. 32, no. 1, pp. 57-68. https://doi.org/10.1093/intimm/dxz060
Chulkina, M, Beswick, EJ & Pinchuk, IV 2020, 'Role of pd-l1 in gut mucosa tolerance and chronic inflammation', International journal of molecular sciences, vol. 21, no. 23, 9165, pp. 1-16. https://doi.org/10.3390/ijms21239165