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Iryna Pinchuk, PhD

Iryna Pinchuk, PhD

Associate Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

Dr. Iryna Pinchuk's research focuses on the mechanisms responsible for the dysregulation of mucosal immune responses, in particular those that are involved in inflammatory bowel disease (IBD) and cancer.

Dr. Pinchuk has pioneered the understanding of the immune function of CD90+ stromal cells (CMFs) in colonic mucosa and demonstrated that in normal gastrointestinal mucosa, CMFs play an immunosuppressive role, contributing to the maintenance of the mucosal tolerance. Dr. Pinchuk also reported that IBD- and gastrointestinal-cancer-derived CMFs have altered tolerogenic function.

Her major study focus is to understand both the interplay between innate and adaptive cells during IBD and cancer development and progression as well as how microbiota modulate these interactions.

Dr. Pinchuk has substantial expertise in the area of human and rodent gastrointestinal mucosal immune responses and more than 15 years of experience in the areas of immunology, cell biology, microbiology and gastrointestinal research.

She holds a patent and has published numerous peer-reviewed articles and two book chapters in the field of immunology, cell biology and microbiology. 

  • Myofibroblasts
  • Helicobacter pylori
  • Stomach
  • Fibroblasts
  • T-Lymphocytes
  • Neoplasms
  • Inflammation
  • Epithelial Cells
  • Mucous Membrane
  • Colonic Neoplasms
  • Helicobacter Infections
  • Stromal Cells

Recent Publications


Villéger, R, Chulkina, M, Mifflin, RC, Powell, DW & Pinchuk, IV 2023, 'Disruption of retinol-mediated IL-6 expression in colon cancer-associated fibroblasts: new perspectives on the role of vitamin A metabolism', Oncotarget, vol. 14, no. 1, pp. 377-381.
Golovko, G, Khanipov, K, Reyes, V, Pinchuk, I & Fofanov, Y 2023, 'Identification of multivariable Boolean patterns in microbiome and microbial gene composition data', BioSystems, vol. 233, 105007.
Waldstein, S, Spengler, M, Pinchuk, IV & Yee, NS 2023, 'Impact of Colorectal Cancer Sidedness and Location on Therapy and Clinical Outcomes: Role of Blood-Based Biopsy for Personalized Treatment', Journal of Personalized Medicine, vol. 13, no. 7, 1114.


Thanki, KK, Johnson, P, Higgins, EJ, Maskey, M, Phillips, CNN, Dash, S, Almenas, FA, Govar, AA, Tian, B, Villéger, R, Beswick, E, Wang, R, Szabo, C, Chao, C, Pinchuk, IV, Hellmich, MR & Módis, K 2022, 'Deletion of cystathionine-γ-lyase in bone marrow-derived cells promotes colitis-associated carcinogenesis', Redox Biology, vol. 55, 102417.
Pinchuk, I, Beswick, E & Das, S 2022, 'Editorial overview: Microbiome', Current Opinion in Physiology, vol. 25, 100481.
Villéger, R, Chulkina, M, Mifflin, RC, Markov, NS, Trieu, J, Sinha, M, Johnson, P, Saada, JI, Adegboyega, PA, Luxon, BA, Beswick, EJ, Powell, DW & Pinchuk, IV 2023, 'Loss of alcohol dehydrogenase 1B in cancer-associated fibroblasts: contribution to the increase of tumor-promoting IL-6 in colon cancer', British Journal of Cancer, vol. 128, no. 4, pp. 537-548.
Zhao, X, Yang, W, Yu, T, Yu, Y, Cui, X, Zhou, Z, Yang, H, Yu, Y, Bilotta, AJ, Yao, S, Xu, J, Zhou, J, Yochum, GS, Koltun, WA, Portolese, A, Zeng, D, Xie, J, Pinchuk, IV, Zhang, H & Cong, Y 2023, 'Th17 Cell-Derived Amphiregulin Promotes Colitis-Associated Intestinal Fibrosis Through Activation of mTOR and MEK in Intestinal Myofibroblasts', Gastroenterology, vol. 164, no. 1, pp. 89-102.


Mohamed, A, Menon, H, Chulkina, M, Yee, NS & Pinchuk, IV 2021, 'Drug–microbiota interaction in colon cancer therapy: Impact of antibiotics', Biomedicines, vol. 9, no. 3, 259, pp. 1-13.
Grim, C, Noble, R, Uribe, G, Khanipov, K, Johnson, P, Koltun, WA, Watts, T, Fofanov, Y, Yochum, GS, Powell, DW, Beswick, EJ & Pinchuk, IV 2021, 'Impairment of Tissue-Resident Mesenchymal Stem Cells in Chronic Ulcerative Colitis and Crohn's Disease', Journal of Crohn's and Colitis, vol. 15, no. 8, pp. 1362-1375.
Li, Y, Chen, J, Bolinger, AA, Chen, H, Liu, Z, Cong, Y, Brasier, AR, Pinchuk, IV, Tian, B & Zhou, J 2021, 'Target-based small molecule drug discovery towards novel therapeutics for inflammatory bowel diseases', Inflammatory bowel diseases, vol. 27, pp. S38-S62.


Wang, J, Cui, R, Clement, CG, Nawgiri, R, Powell, DW, Pinchuk, IV & Watts, TL 2020, 'Activation PDGFR-α/AKT Mediated Signaling Pathways in Oral Squamous Cell Carcinoma by Mesenchymal Stem/Stromal Cells Promotes Anti-apoptosis and Decreased Sensitivity to Cisplatin', Frontiers in Oncology, vol. 10, 552.
Petrey, AC, Qeadan, F, Middleton, EA, Pinchuk, IV, Campbell, RA & Beswick, EJ 2021, 'Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex', Journal of Leukocyte Biology, vol. 109, no. 1, pp. 55-66.
Sayed, IM, Sahan, AZ, Venkova, T, Chakraborty, A, Mukhopadhyay, D, Bimczok, D, Beswick, EJ, Reyes, VE, Pinchuk, I, Sahoo, D, Ghosh, P, Hazra, TK & Das, S 2020, 'Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells', Journal of Biological Chemistry, vol. 295, no. 32, pp. 11082-11098.
Aguirre, JE, Beswick, EJ, Grim, C, Uribe, G, Tafoya, M, Palma, GC, Samedi, V, McKee, R, Villeger, R, Fofanov, Y, Cong, Y, Yochum, G, Koltun, W, Powell, D & Pinchuk, IV 2020, 'Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90+ (myo-)fibroblasts in Crohn’s disease and regulate Th1/Th17 cell responses', International immunology, vol. 32, no. 1, pp. 57-68.
Chulkina, M, Beswick, EJ & Pinchuk, IV 2020, 'Role of pd-l1 in gut mucosa tolerance and chronic inflammation', International journal of molecular sciences, vol. 21, no. 23, 9165, pp. 1-16.