Researcher Profile

Researcher Profile

Iryna Pinchuk, PhD

Iryna Pinchuk, PhD

Associate Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Scientific Program:Mechanisms of Carcinogenesis
ivp5097@psu.edu

Research Interests

Dr. Iryna Pinchuk's research focuses on the mechanisms responsible for the dysregulation of mucosal immune responses, in particular those that are involved in inflammatory bowel disease (IBD) and cancer.

Dr. Pinchuk has pioneered the understanding of the immune function of CD90+ stromal cells (CMFs) in colonic mucosa and demonstrated that in normal gastrointestinal mucosa, CMFs play an immunosuppressive role, contributing to the maintenance of the mucosal tolerance. Dr. Pinchuk also reported that IBD- and gastrointestinal-cancer-derived CMFs have altered tolerogenic function.

Her major study focus is to understand both the interplay between innate and adaptive cells during IBD and cancer development and progression as well as how microbiota modulate these interactions.

Dr. Pinchuk has substantial expertise in the area of human and rodent gastrointestinal mucosal immune responses and more than 15 years of experience in the areas of immunology, cell biology, microbiology and gastrointestinal research.

She holds a patent and has published numerous peer-reviewed articles and two book chapters in the field of immunology, cell biology and microbiology. 

  • Myofibroblasts
  • Helicobacter pylori
  • T-Lymphocytes
  • Stomach
  • Fibroblasts
  • Epithelial Cells
  • Inflammation
  • Neoplasms
  • Stromal Cells
  • Mucous Membrane
  • Helicobacter Infections
  • Cytokines

Recent Publications

2020

Aguirre, JE, Beswick, EJ, Grim, C, Uribe, G, Tafoya, M, Palma, GC, Samedi, V, McKee, R, Villeger, R, Fofanov, Y, Cong, Y, Yochum, G, Koltun, W, Powell, D & Pinchuk, IV 2020, 'Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90+ (myo-)fibroblasts in Crohn’s disease and regulate Th1/Th17 cell responses', International immunology, vol. 32, no. 1, pp. 57-68. https://doi.org/10.1093/intimm/dxz060

2018

Beswick, EJ, Grim, C, Singh, A, Aguirre, JE, Tafoya, M, Qiu, S, Rogler, G, McKee, R, Samedi, V, Ma, TY, Reyes, VE, Powell, DW & Pinchuk, IV 2018, 'Expression of programmed death-ligand 1 by human colonic CD90+ stromal cells differs between ulcerative colitis and Crohn's disease and determines their capacity to suppress Th1 cells', Frontiers in immunology, vol. 9, no. MAY, 1125. https://doi.org/10.3389/fimmu.2018.01125
Pinchuk, I & Powell, DW 2018, Immunosuppression by intestinal stromal cells. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1060, Springer New York LLC, pp. 115-129. https://doi.org/10.1007/978-3-319-78127-3_7
Uribe, G, Villéger, R, Bressollier, P, Dillard, RN, Worthley, DL, Wang, TC, Powell, DW, Urdaci, MC & Pinchuk, IV 2018, 'Lactobacillus rhamnosus GG increases cyclooxygenase-2 expression and prostaglandin E2 secretion in colonic myofibroblasts via a MyD88-dependent mechanism during homeostasis', Cellular Microbiology, vol. 20, no. 11, e12871. https://doi.org/10.1111/cmi.12871
Phinney, BB, Ray, AL, Peretti, AS, Jerman, SJ, Grim, C, Pinchuk, IV & Beswick, EJ 2018, 'MK2 regulates macrophage chemokine activity and recruitment to promote colon tumor growth', Frontiers in immunology, vol. 9, no. SEP, 1857. https://doi.org/10.3389/fimmu.2018.01857

2017

Ijaz, T, Sun, H, Pinchuk, IV, Milewicz, DM, Tilton, RG & Brasier, AR 2017, 'Deletion of NF-κB/RelA in angiotensin II-sensitive mesenchymal cells blocks aortic vascular inflammation and abdominal aortic aneurysm formation', Arteriosclerosis, thrombosis, and vascular biology, vol. 37, no. 10, pp. 1881-1890. https://doi.org/10.1161/ATVBAHA.117.309863
Falik Zaccai, TC, Savitzki, D, Zivony-Elboum, Y, Vilboux, T, Fitts, EC, Shoval, Y, Kalfon, L, Samra, N, Keren, Z, Gross, B, Chasnyk, N, Straussberg, R, Mullikin, JC, Teer, JK, Geiger, D, Kornitzer, D, Bitterman-Deutsch, O, Samson, AO, Wakamiya, M, Peterson, JW, Kirtley, ML, Pinchuk, IV, Baze, WB, Gahl, WA, Kleta, R, Anikster, Y & Chopra, AK 2017, 'Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy', Brain, vol. 140, no. 2, pp. 370-386. https://doi.org/10.1093/brain/aww295

2016

Ray, AL, Castillo, EF, Morris, KT, Nofchissey, RA, Weston, LL, Samedi, VG, Hanson, JA, Gaestel, M, Pinchuk, IV & Beswick, EJ 2016, 'Blockade of MK2 is protective in inflammation-associated colorectal cancer development', International Journal of Cancer, vol. 138, no. 3, pp. 770-775. https://doi.org/10.1002/ijc.29716
Huynh, PT, Beswick, EJ, Coronado, YA, Johnson, P, O'Connell, MR, Watts, T, Singh, P, Qiu, S, Morris, K, Powell, DW & Pinchuk, IV 2016, 'CD90+ stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer', International Journal of Cancer, vol. 138, no. 8, pp. 1971-1981. https://doi.org/10.1002/ijc.29939
Johnson, P, Beswick, EJ, Chao, C, Powell, DW, Hellmich, MR & Pinchuk, IV 2016, 'Isolation of CD 90+ fibroblast/myofibroblasts from human frozen gastrointestinal specimens', Journal of Visualized Experiments, vol. 2016, no. 107, e53691. https://doi.org/10.3791/53691
Watts, TL, Cui, R, Szaniszlo, P, Resto, VA, Powell, DW & Pinchuk, IV 2016, 'PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment', Journal of Translational Medicine, vol. 14, no. 1, 337. https://doi.org/10.1186/s12967-016-1091-6
Snook, JD, Chesson, CB, Peniche, AG, Dann, SM, Paulucci, A, Pinchuk, IV & Rudra, JS 2016, 'Peptide nanofiber-CaCO3 composite microparticles as adjuvant-free oral vaccine delivery vehicles', Journal of Materials Chemistry B, vol. 4, no. 9, pp. 1640-1649. https://doi.org/10.1039/c5tb01623a

Clinical Trials Search


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