Researcher Profile

Researcher Profile

Iryna Pinchuk, PhD

Iryna Pinchuk, PhD

Associate Professor, Department of Medicine
Division of Gastroenterology and Hepatology
Scientific Program:Mechanisms of Carcinogenesis
ivp5097@psu.edu

Research Interests

Dr. Iryna Pinchuk's research focuses on the mechanisms responsible for the dysregulation of mucosal immune responses, in particular those that are involved in inflammatory bowel disease (IBD) and cancer.

Dr. Pinchuk has pioneered the understanding of the immune function of CD90+ stromal cells (CMFs) in colonic mucosa and demonstrated that in normal gastrointestinal mucosa, CMFs play an immunosuppressive role, contributing to the maintenance of the mucosal tolerance. Dr. Pinchuk also reported that IBD- and gastrointestinal-cancer-derived CMFs have altered tolerogenic function.

Her major study focus is to understand both the interplay between innate and adaptive cells during IBD and cancer development and progression as well as how microbiota modulate these interactions.

Dr. Pinchuk has substantial expertise in the area of human and rodent gastrointestinal mucosal immune responses and more than 15 years of experience in the areas of immunology, cell biology, microbiology and gastrointestinal research.

She holds a patent and has published numerous peer-reviewed articles and two book chapters in the field of immunology, cell biology and microbiology. 

  • Myofibroblasts
  • Helicobacter pylori
  • Stomach
  • T-Lymphocytes
  • Fibroblasts
  • Epithelial Cells
  • Inflammation
  • Neoplasms
  • Mucous Membrane
  • Helicobacter Infections
  • Stromal Cells
  • Colonic Neoplasms

Recent Publications

2021

Mohamed, A, Menon, H, Chulkina, M, Yee, NS & Pinchuk, IV 2021, 'Drug–microbiota interaction in colon cancer therapy: Impact of antibiotics', Biomedicines, vol. 9, no. 3, 259, pp. 1-13. https://doi.org/10.3390/biomedicines9030259

2020

Wang, J, Cui, R, Clement, CG, Nawgiri, R, Powell, DW, Pinchuk, IV & Watts, TL 2020, 'Activation PDGFR-α/AKT Mediated Signaling Pathways in Oral Squamous Cell Carcinoma by Mesenchymal Stem/Stromal Cells Promotes Anti-apoptosis and Decreased Sensitivity to Cisplatin', Frontiers in Oncology, vol. 10, 552. https://doi.org/10.3389/fonc.2020.00552
Petrey, AC, Qeadan, F, Middleton, EA, Pinchuk, IV, Campbell, RA & Beswick, EJ 2021, 'Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex', Journal of Leukocyte Biology, vol. 109, no. 1, pp. 55-66. https://doi.org/10.1002/JLB.3COVA0820-410RRR
Sayed, IM, Sahan, AZ, Venkova, T, Chakraborty, A, Mukhopadhyay, D, Bimczok, D, Beswick, EJ, Reyes, VE, Pinchuk, I, Sahoo, D, Ghosh, P, Hazra, TK & Das, S 2020, 'Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells', Journal of Biological Chemistry, vol. 295, no. 32, pp. 11082-11098. https://doi.org/10.1074/jbc.ra119.009981
Aguirre, JE, Beswick, EJ, Grim, C, Uribe, G, Tafoya, M, Palma, GC, Samedi, V, McKee, R, Villeger, R, Fofanov, Y, Cong, Y, Yochum, G, Koltun, W, Powell, D & Pinchuk, IV 2020, 'Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90+ (myo-)fibroblasts in Crohn’s disease and regulate Th1/Th17 cell responses', International immunology, vol. 32, no. 1, pp. 57-68. https://doi.org/10.1093/intimm/dxz060
Chulkina, M, Beswick, EJ & Pinchuk, IV 2020, 'Role of pd-l1 in gut mucosa tolerance and chronic inflammation', International journal of molecular sciences, vol. 21, no. 23, 9165, pp. 1-16. https://doi.org/10.3390/ijms21239165

2018

Beswick, EJ, Grim, C, Singh, A, Aguirre, JE, Tafoya, M, Qiu, S, Rogler, G, McKee, R, Samedi, V, Ma, TY, Reyes, VE, Powell, DW & Pinchuk, IV 2018, 'Expression of programmed death-ligand 1 by human colonic CD90+ stromal cells differs between ulcerative colitis and Crohn's disease and determines their capacity to suppress Th1 cells', Frontiers in immunology, vol. 9, no. MAY, 1125. https://doi.org/10.3389/fimmu.2018.01125
Pinchuk, I & Powell, DW 2018, Immunosuppression by intestinal stromal cells. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1060, Springer New York LLC, pp. 115-129. https://doi.org/10.1007/978-3-319-78127-3_7
Uribe, G, Villéger, R, Bressollier, P, Dillard, RN, Worthley, DL, Wang, TC, Powell, DW, Urdaci, MC & Pinchuk, IV 2018, 'Lactobacillus rhamnosus GG increases cyclooxygenase-2 expression and prostaglandin E2 secretion in colonic myofibroblasts via a MyD88-dependent mechanism during homeostasis', Cellular Microbiology, vol. 20, no. 11, e12871. https://doi.org/10.1111/cmi.12871
Phinney, BB, Ray, AL, Peretti, AS, Jerman, SJ, Grim, C, Pinchuk, IV & Beswick, EJ 2018, 'MK2 regulates macrophage chemokine activity and recruitment to promote colon tumor growth', Frontiers in immunology, vol. 9, no. SEP, 1857. https://doi.org/10.3389/fimmu.2018.01857

2017

Ijaz, T, Sun, H, Pinchuk, IV, Milewicz, DM, Tilton, RG & Brasier, AR 2017, 'Deletion of NF-κB/RelA in angiotensin II-sensitive mesenchymal cells blocks aortic vascular inflammation and abdominal aortic aneurysm formation', Arteriosclerosis, thrombosis, and vascular biology, vol. 37, no. 10, pp. 1881-1890. https://doi.org/10.1161/ATVBAHA.117.309863
Falik Zaccai, TC, Savitzki, D, Zivony-Elboum, Y, Vilboux, T, Fitts, EC, Shoval, Y, Kalfon, L, Samra, N, Keren, Z, Gross, B, Chasnyk, N, Straussberg, R, Mullikin, JC, Teer, JK, Geiger, D, Kornitzer, D, Bitterman-Deutsch, O, Samson, AO, Wakamiya, M, Peterson, JW, Kirtley, ML, Pinchuk, IV, Baze, WB, Gahl, WA, Kleta, R, Anikster, Y & Chopra, AK 2017, 'Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy', Brain, vol. 140, no. 2, pp. 370-386. https://doi.org/10.1093/brain/aww295

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