Gustavo Alberto Nader - Penn State Cancer Institute
Researcher Profile
Gustavo Alberto Nader
Professor, Kinesiology
Associate Professor, Kinesiology
Associate Professor, Kinesiology
Scientific Program:Mechanisms of Carcinogenesis
Research Interests
- Muscles
- Skeletal Muscle
- Hypertrophy
- Proteins
- Exercise
- Gene Expression
- Skeletal Muscle Fibers
- Genes
- Growth
- Ribosomal DNA
- Resistance Training
- Phosphorylation
Recent Publications
2023
Roberts, MD, McCarthy, JJ, Hornberger, TA, Phillips, SM, Mackey, AL, Nader, GA, Boppart, MD, Kavazis, AN, Reidy, PT, Ogasawara, R, Libardi, CA, Ugrinowitsch, C, Booth, FW & Esser, KA 2023, 'Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions', Physiological Reviews. https://doi.org/10.1152/physrev.00039.2022
2022
Belcher, DJ, Guitart, M, Hain, B, Kim, HG, Waning, D, Barreiro, E & Nader, GA 2022, 'LP07 and LLC preclinical models of lung cancer induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting', Journal of applied physiology, vol. 133, no. 6, pp. 1260-1272. https://doi.org/10.1152/japplphysiol.00246.2022
Kim, HG, Huot, JR, Pin, F, Belcher, DJ, Bonetto, A & Nader, GA 2022, 'Metastatic or xenograft colorectal cancer models induce divergent anabolic deficits and expression of pro-inflammatory effectors of muscle wasting in a tumor-type-dependent manner', Journal of applied physiology, vol. 133, no. 6, pp. 1273-1283. https://doi.org/10.1152/japplphysiol.00247.2022
2021
Guo, B, Bennet, D, Belcher, DJ, Kim, HG & Nader, GA 2021, 'Chemotherapy agents reduce protein synthesis and ribosomal capacity in myotubes independent of oxidative stress', American Journal of Physiology - Cell Physiology, vol. 321, no. 6, pp. C1000-C1009. https://doi.org/10.1152/ajpcell.00116.2021
Kim, HG, Huot, JR, Pin, F, Guo, B, Bonetto, A & Nader, GA 2021, 'Reduced rDNA transcription diminishes skeletal muscle ribosomal capacity and protein synthesis in cancer cachexia', FASEB Journal, vol. 35, no. 2, e21335. https://doi.org/10.1096/fj.202002257R
2019
Shigemura, M, Lecuona, E, Angulo, M, Dada, LA, Edwards, MB, Welch, LC, Casalino-Matsuda, SM, Sporn, PHS, Vadász, I, Helenius, IT, Nader, GA, Gruenbaum, Y, Sharabi, K, Cummins, E, Taylor, C, Bharat, A, Gottardi, CJ, Beitel, GJ, Kaminski, N, Budinger, GRS, Berdnikovs, S & Sznajder, JI 2019, 'Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans', Scientific reports, vol. 9, no. 1, 18251. https://doi.org/10.1038/s41598-019-54683-0
Liu, C, Gidlund, EK, Witasp, A, Qureshi, AR, Söderberg, M, Thorell, A, Nader, GA, Barany, P, Stenvinkel, P & von Walden, F 2019, 'Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease', American journal of physiology. Renal physiology, vol. 317, no. 5, pp. F1122-F1131. https://doi.org/10.1152/ajprenal.00202.2019
Kim, HG, Guo, B & Nader, GA 2019, 'Regulation of Ribosome Biogenesis during Skeletal Muscle Hypertrophy', Exercise and Sport Sciences Reviews, vol. 47, no. 2, pp. 91-97. https://doi.org/10.1249/JES.0000000000000179