Researcher Profile

Researcher Profile

Zhenqiu Liu, PhD

Zhenqiu Liu, PhD

Associate Professor, Department of Public Health Sciences
Division of Biostatistics and Bioinformatics
Scientific Program:Next-Generation Therapies

Research Interests

  • Neoplasms
  • Genes
  • Gene Expression
  • Prostatic Neoplasms
  • Biomarkers
  • Messenger RNA
  • Metagenomics
  • Phenotype
  • Non-Small Cell Lung Carcinoma
  • Survival
  • Carrier Proteins
  • Lung Neoplasms

Recent Publications


Grimley, PM, Liu, Z, Darcy, KM, Hueman, MT, Wang, H, Sheng, L, Henson, DE & Chen, D 2021, 'A prognostic system for epithelial ovarian carcinomas using machine learning', Acta Obstetricia et Gynecologica Scandinavica, vol. 100, no. 8, pp. 1511-1519.
Liu, C, Billet, S, Choudhury, D, Cheng, R, Haldar, S, Fernandez, A, Biondi, S, Liu, Z, Zhou, H & Bhowmick, NA 2021, 'Bone marrow mesenchymal stem cells interact with head and neck squamous cell carcinoma cells to promote cancer progression and drug resistance', Neoplasia (United States), vol. 23, no. 1, pp. 118-128.
Liu, Z 2021, 'Clustering single-cell rna-seq data with regularized gaussian graphical model', Genes, vol. 12, no. 2, 311, pp. 1-12.
Liu, Z, Spiegelman, V & Wang, H-G 2021, 'Distinct noncoding RNAs and RNA binding proteins associated with high-risk pediatric and adult acute myeloid leukemias detected by regulatory network analysis', Cancer Reports.
Hueman, M, Wang, H, Liu, Z, Henson, D, Nguyen, C, Park, D, Sheng, L & Chen, D 2021, 'Expanding TNM for lung cancer through machine learning', Thoracic Cancer, vol. 12, no. 9, pp. 1423-1430.
Liu, X, Tian, G & Liu, Z 2021, 'Identification of novel genes for triple-negative breast cancer with semiparametric gene-based analysis', Journal of Applied Statistics.
Yang, CQ, Wang, H, Liu, Z, Hueman, MT, Bhaskaran, A, Henson, DE, Sheng, L & Chen, D 2021, 'Integrating additional factors into the TNM staging for cutaneous melanoma by machine learning', PloS one, vol. 16, no. 9 September, e0257949.


Kawaguchi, ES, Suchard, MA, Liu, Z & Li, G 2020, 'A surrogate ℓ0 sparse Cox's regression with applications to sparse high-dimensional massive sample size time-to-event data', Statistics in Medicine, vol. 39, no. 6, pp. 675-686.
Sun, L, Jiang, L, Grant, CN, Wang, HG, Gragnoli, C, Liu, Z & Wu, R 2020, 'Computational identification of gene networks as a biomarker of neuroblastoma risk', Cancers, vol. 12, no. 8, 2086, pp. 1-17.
Liu, Z, Grant, CN, Sun, L, Miller, BA, Spiegelman, VS & Wang, HG 2020, 'Expression patterns of immune genes reveal heterogeneous subtypes of high-risk neuroblastoma', Cancers, vol. 12, no. 7, 1739, pp. 1-16.
Gebru, MT, Atkinson, JM, Young, MM, Zhang, L, Tang, Z, Liu, Z, Lu, P, Dower, CM, Chen, L, Annageldiyev, C, Sharma, A, Kawasawa, YI, Zhao, Z, Miller, BA, Claxton, DF & Wang, HG 2020, 'Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia', Blood, vol. 136, no. 9, pp. 1067-1079.
Rice, SJ, Liu, X, Hyland, V, Liu, Z & Belani, CP 2020, 'Mutations in genes connected with the TCF7L2 transcription factor are associated with a poor prognosis in non-small cell lung cancer', Lung Cancer, vol. 141, pp. 97-100.
Placencio-Hickok, VR, Madhav, A, Kim, S, Duong, F, Angara, B, Liu, Z & Bhowmick, NA 2020, 'Soluble CD105 is prognostic of disease recurrence in prostate cancer patients', Endocrine-Related Cancer, vol. 27, no. 1, pp. 1-9.
Liu, Z 2020, 'Visualizing single-cell rna-seq data with semisupervised principal component analysis', International journal of molecular sciences, vol. 21, no. 16, 5797, pp. 1-12.


Kakuta, Y, Kawai, Y, Naito, T, Hirano, A, Umeno, J, Fuyuno, Y, Liu, Z, Li, D, Nakano, T, Izumiyama, Y, Ichikawa, R, Okamoto, D, Nagai, H, Matsumoto, S, Yamamoto, K, Yokoyama, N, Chiba, H, Shimoyama, Y, Onodera, M, Moroi, R, Kuroha, M, Kanazawa, Y, Kimura, T, Shiga, H, Endo, K, Negoro, K, Yasuda, J, Esaki, M, Tokunaga, K, Nakamura, M, Matsumoto, T, McGovern, DPB, Nagasaki, M, Kinouchi, Y, Shimosegawa, T & Masamune, A 2019, 'A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn's Disease in Japanese Individuals', Journal of Crohn's and Colitis, vol. 13, no. 5, pp. 648-658.
Elcheva, I, Sneed, M, Frazee, S, Liu, Z, Zhu, J, Wood, T, Hendrickson, S, Oehler, C, Garcia, B & Spiegelman, VS 2019, 'A novel hiPSC-derived system for hematoendothelial and myeloid blood toxicity screens identifies compounds promoting and inhibiting endothelial-to-hematopoietic transition', Toxicology in Vitro, vol. 61, 104622.
Chen, C, Jiang, L, Fu, G, Wang, M, Wang, Y, Shen, B, Liu, Z, Wang, Z, Hou, W, Berceli, SA & Wu, R 2019, 'An omnidirectional visualization model of personalized gene regulatory networks', NPJ systems biology and applications, vol. 5.
Liu, Z, Yee, PP, Wei, Y, Liu, Z, Imamura, Y & Li, W 2019, 'Differential YAP expression in glioma cells induces cell competition and promotes tumorigenesis', Journal of Cell Science, vol. 132, no. 5, jcs225714.
Ghoshal, A, Rodrigues, LC, Gowda, CP, Elcheva, IA, Liu, Z, Abraham, T & Spiegelman, VS 2019, 'Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis', Oncogene, vol. 38, no. 21, pp. 4182-4196.
Yang, YM, Noureddin, M, Liu, C, Ohashi, K, Kim, SY, Ramnath, D, Powell, EE, Sweet, MJ, Roh, YS, Hsin, IF, Deng, N, Liu, Z, Liang, J, Mena, E, Shouhed, D, Schwabe, RF, Jiang, D, Lu, SC, Noble, PW & Seki, E 2019, 'Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis', Science Translational Medicine, vol. 11, no. 496, eaat9284.
Geng, Y, Liu, X, Liang, J, Habiel, DM, Kulur, V, Coelho, AL, Deng, N, Xie, T, Wang, Y, Liu, N, Huang, G, Kurkciyan, A, Liu, Z, Tang, J, Hogaboam, CM, Jiang, D & Noble, PW 2019, 'PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis', JCI Insight, vol. 4, no. 6, e125326.
Elcheva, IA, Wood, T, Chiarolanzio, K, Chim, B, Wong, M, Singh, V, Gowda, CP, Lu, Q, Hafner, M, Dovat, S, Liu, Z, Muljo, SA & Spiegelman, VS 2020, 'RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1', Leukemia, vol. 34, no. 5, pp. 1354-1363.
Liu, Z, Elashoff, D & Piantadosi, S 2019, 'Sparse support vector machines with L0 approximation for ultra-high dimensional omics data', Artificial Intelligence in Medicine, vol. 96, pp. 134-141.
Yang, JW, Murray, B, Barbier-Torres, L, Liu, T, Liu, Z, Yang, H, Fan, W, Wang, J, Li, Y, Seki, E, Mato, JM & Lu, SC 2019, 'The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers', Journal of Biological Chemistry, vol. 294, no. 6, pp. 1984-1996.


Madhav, A, Andres, A, Duong, F, Mishra, R, Haldar, S, Liu, Z, Angara, B, Gottlieb, R, Zumsteg, ZS & Bhowmick, NA 2018, 'Antagonizing CD105 enhances radiation sensitivity in prostate cancer', Oncogene, vol. 37, no. 32, pp. 4385-4397.
Dai, L, Chen, K, Sun, Z, Liu, Z & Li, G 2018, 'Broken adaptive ridge regression and its asymptotic properties', Journal of Multivariate Analysis, vol. 168, pp. 334-351.
Kato, M, Placencio-Hickok, VR, Madhav, A, Haldar, S, Tripathi, M, Billet, S, Mishra, R, Smith, B, Rohena-Rivera, K, Agarwal, P, Duong, F, Angara, B, Hickok, D, Liu, Z & Bhowmick, NA 2019, 'Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner', Oncogene, vol. 38, no. 5, pp. 716-730.
Liu, T, Yang, H, Fan, W, Tu, J, Li, TWH, Wang, J, Shen, H, Yang, JW, Xiong, T, Steggerda, J, Liu, Z, Noureddin, M, Maldonado, SS, Annamalai, A, Seki, E, Mato, JM & Lu, SC 2018, 'Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer', Gastroenterology, vol. 155, no. 2, pp. 557-571.e14.
Liu, Z & Lin, S 2018, Sparse Treatment-Effect Model for Taxon Identification with High-Dimensional Metagenomic Data. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1849, Humana Press Inc., pp. 309-318.
Mishra, R, Haldar, S, Placencio, V, Madhav, A, Rohena-Rivera, K, Agarwal, P, Duong, F, Angara, B, Tripathi, M, Liu, Z, Gottlieb, RA, Wagner, S, Posadas, EM & Bhowmick, NA 2018, 'Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming', Journal of Clinical Investigation, vol. 128, no. 10, pp. 4472-4484.

Clinical Trials Search

Children (age < 18 years)
Adults (age >= 18 years)