Guy Edmund Townsend, PhD - Penn State Cancer Institute
Researcher Profile
Guy Edmund Townsend, PhD
Associate Professor, Department of Molecular and Precision Medicine
One Health Microbiome Center
One Health Microbiome Center
Recent Publications
2026
Krypotou, E, Ruff, KM, McKinney, LK, Townsend, GE, Wang, JD, Pappu, RV & Groisman, EA 2026, 'Short autoinhibitory sequences control phase separation of an essential bacterial transcription termination factor', EMBO Journal. https://doi.org/10.1038/s44318-026-00793-1
2025
Koo, H, Heber, K, Tian, S, Connolly, ST, Hao, F, Zhao, J, Swencki-Underwood, B, Patterson, AD, Townsend, GE & Bisanz, JE 2025, 'A synthetic gut microbiota provides an understanding of the maintenance and functional impact of phage', mBio, vol. 16, no. 12, pp. 1-19. https://doi.org/10.1128/mbio.02341-25
Kabonick, SG, Verma, K, Modesto, JL, Pearce, VH, Winokur, KM, Groisman, EA & Townsend, GE 2025, 'Hierarchical glycolytic pathways control the carbohydrate utilization regulator in human gut Bacteroides', Nature communications, vol. 16, no. 1, 4488. https://doi.org/10.1038/s41467-025-59704-3
2023
Krypotou, E, Townsend, GE, Gao, X, Tachiyama, S, Liu, J, Pokorzynski, ND, Goodman, AL & Groisman, EA 2023, 'Bacteria require phase separation for fitness in the mammalian gut', Science, vol. 379, no. 6637, eabn7229. https://doi.org/10.1126/science.abn7229
Pearce, VH, Groisman, EA & Townsend, GE 2023, 'Dietary sugars silence the master regulator of carbohydrate utilization in human gut Bacteroides species', Gut microbes, vol. 15, no. 1, 2221484. https://doi.org/10.1080/19490976.2023.2221484
Modesto, JL, Pearce, VH & Townsend, GE 2023, 'Harnessing gut microbes for glycan detection and quantification', Nature communications, vol. 14, no. 1, 275. https://doi.org/10.1038/s41467-022-35626-2
2022
Han, W, Peng, BZ, Wang, C, Townsend, GE, Barry, NA, Peske, F, Goodman, AL, Liu, J, Rodnina, MV & Groisman, EA 2023, 'Gut colonization by Bacteroides requires translation by an EF-G paralog lacking GTPase activity', EMBO Journal, vol. 42, no. 2, e112372. https://doi.org/10.15252/embj.2022112372