Kentaro Minagawa, MD, PhD - Penn State Cancer Institute
Researcher Profile
Kentaro Minagawa, MD, PhD
Assistant Professor, Department of Medicine
Division of Hematology and Oncology
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Research Interests
- Therapeutics
- T-Lymphocytes
- Genes
- Bone Marrow
- Neoplasms
- Mycophenolic Acid
- Transplants
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia
- Myelodysplastic Syndromes
- Hematopoietic Stem Cells
- Suicide
Recent Publications
2022
Falcon, C, Smith, L, Al-Obaidi, M, Abu Zaanona, M, Purvis, K, Minagawa, K, Athar, M, Salzman, D, Bhatia, R, Goldman, F & Di Stasi, A 2022, 'Combinatorial suicide gene strategies for the safety of cell therapies', Frontiers in immunology, vol. 13, 975233. https://doi.org/10.3389/fimmu.2022.975233
Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2023, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology, vol. 102, no. 3, pp. 613-620. https://doi.org/10.1007/s00277-022-05077-2
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Pizzola, CJ, Cioccio, J, Rakszawski, KL, Nickolich, M, Ehmann, WC, Rybka, WB, Wirk, B, Naik, S, Zheng, H, Silar, B, Shike, H, Zhou, S, Mineishi, S, Minagawa, K & Claxton, DF 2022, 'Non-myeloablative allogeneic stem cell transplant with fludarabine and reduced dose cyclophosphamide in acute myeloid leukemia for older adults with comorbidities', Bone Marrow Transplantation, vol. 57, no. 11, pp. 1743-1745. https://doi.org/10.1038/s41409-022-01821-4
Jamy, O, Arora, S, Meredith, R, Salzman, D, Di Stasi, A, Minagawa, K, Mineishi, S & Saad, A 2022, 'Phase II study of myeloablative allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia in adults using fludarabine and total body irradiation 12 Gy', Bone Marrow Transplantation, vol. 57, no. 10, pp. 1597-1599. https://doi.org/10.1038/s41409-022-01757-9
2021
Tomita, T, Kato, M, Mishima, T, Matsunaga, Y, Sanjo, H, Ito, KI, Minagawa, K, Matsui, T, Oikawa, H, Takahashi, S, Takao, T, Iwai, N, Mino, T, Takeuchi, O, Maru, Y & Hiratsuka, S 2021, 'Extracellular mRNA transported to the nucleus exerts translation-independent function', Nature communications, vol. 12, no. 1, 3655. https://doi.org/10.1038/s41467-021-23969-1
Ishii, S, Suzuki, T, Wakahashi, K, Asada, N, Kawano, Y, Kawano, H, Sada, A, Minagawa, K, Nakamura, Y, Mizuno, S, Takahashi, S, Matsui, T & Katayama, Y 2021, 'FGF-23 from erythroblasts promotes hematopoietic progenitor mobilization', Blood, vol. 137, no. 11, pp. 1457-1467. https://doi.org/10.1182/blood.2020007172
Shah, N, Rakszawski, K, Nickolich, M, Ehmann, C, Wirk, B, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Mackey, G, Greiner, R, Brown, V, Claxton, D, Mineishi, S & Minagawa, K 2021, 'Improved outcome in AML relapse after allogeneic transplant with high-intensity chemotherapy followed by 2nd allogeneic stem cell transplant or donor lymphocyte infusion', Annals of Hematology, vol. 100, no. 10, pp. 2585-2592. https://doi.org/10.1007/s00277-021-04616-7
Suzuki, T, Ishii, S, Shinohara, M, Kawano, Y, Wakahashi, K, Kawano, H, Sada, A, Minagawa, K, Hamada, M, Takahashi, S, Furuyashiki, T, Tan, NS, Matsui, T & Katayama, Y 2021, 'Mobilization efficiency is critically regulated by fat via marrow PPARd', Haematologica, vol. 106, no. 6, pp. 1671-1683. https://doi.org/10.3324/haematol.2020.265751
Jamy, O, Innis-Shelton, R, Bal, S, Paluri, R, Salzman, D, Di Stasi, A, Costa, L, Meredith, R, Lamb, L, Minagawa, K, Mineishi, S & Saad, A 2021, 'Phase II clinical trial of one dose of post-transplant cyclophosphamide for graft versus host disease prevention following myeloablative, peripheral blood stem cell, matched-unrelated donor transplantation', American Journal of Hematology, vol. 96, no. 10, pp. E396-E398. https://doi.org/10.1002/ajh.26296
2019
Minagawa, K, Al-Obaidi, M & Di Stasi, A 2019, Generation of suicide gene-modified chimeric antigen receptor-redirected T-cells for cancer immunotherapy. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1895, Humana Press Inc., pp. 57-73. https://doi.org/10.1007/978-1-4939-8922-5_5
Wakahashi, K, Minagawa, K, Kawano, Y, Kawano, H, Suzuki, T, Ishii, S, Sada, A, Asada, N, Sato, M, Kato, S, Shide, K, Shimoda, K, Matsui, T & Katayama, Y 2019, 'Vitamin D receptor–mediated skewed differentiation of macrophages initiates myelofibrosis and subsequent osteosclerosis', Blood, vol. 133, no. 15, pp. 1619-1629. https://doi.org/10.1182/blood-2018-09-876615