Kentaro Minagawa, MD, PhD - Penn State Cancer Institute
Researcher Profile
Kentaro Minagawa, MD, PhD
Assistant Professor, Department of Medicine
Division of Hematology and Oncology
Division of Hematology and Oncology
Scientific Program:Next-Generation Therapies
Research Interests
- Therapeutics
- T-Lymphocytes
- Genes
- Bone Marrow
- Neoplasms
- Mycophenolic Acid
- Transplants
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia
- Myelodysplastic Syndromes
- Hematopoietic Stem Cells
- Suicide
Clinical Trials
EAA173 Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM)
A Phase 2, Open-Label Trial to Evaluate Safety of Epcoritamab Monotherapy in Subjects with Relapsed or Refractory Diffuse Large B-Cell Lymphoma and Classic Follicular Lymphoma (Previously Grade 1-3a) when Administered in the Outpatient Setting
Protocol for a Research Sample Repository for Allogeneic Hematopoietic Stem Cell Transplantation
A Phase 3 Randomized, Open-Label, Multicenter Study Evaluating the Efficacy of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Subjects with Relapsed/Refractory Follicular Lymphoma
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications
Assessment of Allogeneic Hematopoietic Cell Transplantation in Medicare Beneficiaries with Multiple Myeloma: A Study to Develop Evidence of Effectiveness for the Centers for Medicare and Medicaid Services (CMS)
Recent Publications
2024
Naik, S, Rakszawski, K, Zheng, H, Claxton, D, Minagawa, K & Mineishi, S 2024, 'Clofarabine Preconditioning followed by Allogeneic Transplant Using TBI and Post-Transplant Cyclophosphamide for Relapsed Refractory Leukemia', International journal of molecular sciences, vol. 25, no. 2, 957. https://doi.org/10.3390/ijms25020957
Zulch, E, Inoue, Y, Cioccio, J, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Rybka, W, Ehmann, C, Sivik, J, Mierski, J, Silar, B, Vajdic, C, Greiner, R, Brown, V, Hohl, R, Claxton, D, Shike, H, Paules, CI, Mineishi, S & Minagawa, K 2024, 'Impact of post-transplant cyclophosphamide and splenomegaly on primary graft failure and multi-lineage cytopenia after allogeneic hematopoietic cell transplantation', Leukemia Research, vol. 143, 107530. https://doi.org/10.1016/j.leukres.2024.107530
Guare, EG, Hale, CM, Sivik, J, Lehman, E, Inoue, Y, Rakszawski, K, Songdej, N, Nickolich, M, Zheng, H, Naik, S, Claxton, D, Rybka, W, Hohl, R, Mineishi, S, Minagawa, K & Paules, CI 2024, 'The addition of doxycycline to fluoroquinolones for bacterial prophylaxis in autologous stem cell transplantation for multiple myeloma', Transplant Infectious Disease, vol. 26, no. 2, e14241. https://doi.org/10.1111/tid.14241
2023
Jia, B, Zhao, C, Minagawa, K, Shike, H, Claxton, DF, Ehmann, WC, Rybka, WB, Mineishi, S, Wang, M, Schell, TD, Prabhu, KS, Paulson, RF, Zhang, Y, Shultz, LD & Zheng, H 2023, 'Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model', Journal of Immunology, vol. 211, no. 9, pp. 1426-1437. https://doi.org/10.4049/jimmunol.2300111
Zhou, H, Jia, B, Annageldiyev, C, Minagawa, K, Zhao, C, Mineishi, S, Ehmann, WC, Naik, SG, Cioccio, J, Wirk, B, Songdej, N, Rakszawski, KL, Nickolich, MS, Shen, J & Zheng, H 2023, 'CD26lowPD-1+ CD8 T cells are terminally exhausted and associated with leukemia progression in acute myeloid leukemia', Frontiers in immunology, vol. 14, 1169144. https://doi.org/10.3389/fimmu.2023.1169144
Yeware, A, Helton, A, Dong, Y, Dong, C, Pritchard, J, Mineishi, S, Minagawa, K, Schell, T & Hayes, D 2023, 'Novel fourth generation-like CARmiR cells release therapeutic miRNA via exosomes and enhance glioblastoma cell killing activity', Biochemical Engineering Journal, vol. 199, 109068. https://doi.org/10.1016/j.bej.2023.109068
Minagawa, K, Wakahashi, K, Fukui, C, Kawano, Y, Kawano, H, Suzuki, T, Ishii, S, Sada, A, Nishikawa, S, Asada, N, Katayama, Y & Matsui, T 2023, 'Tfl deletion induces extraordinary Cxcl13 secretion and cachexia in VavP-Bcl2 transgenic mice', Frontiers in immunology, vol. 14, 1197112. https://doi.org/10.3389/fimmu.2023.1197112
2022
Falcon, C, Smith, L, Al-Obaidi, M, Abu Zaanona, M, Purvis, K, Minagawa, K, Athar, M, Salzman, D, Bhatia, R, Goldman, F & Di Stasi, A 2022, 'Combinatorial suicide gene strategies for the safety of cell therapies', Frontiers in immunology, vol. 13, 975233. https://doi.org/10.3389/fimmu.2022.975233
Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Shah, N, Tuanquin, L, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Shike, H 2023, 'Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis', Annals of Hematology, vol. 102, no. 3, pp. 613-620. https://doi.org/10.1007/s00277-022-05077-2
Shah, N, Cioccio, J, Rakszawski, K, Zheng, H, Nickolich, M, Naik, S, Wirk, B, Rybka, W, Ehmann, C, Silar, B, Vajdic, C, Mierski, J, Zhou, S, Shike, H, Greiner, R, Brown, V, Hohl, R, Claxton, D, Mineishi, S, Minagawa, K & Tuanquin, L 2022, 'Low-dose total body irradiation promotes T-cells donor chimerism in reduced-intensity/non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide', Leukemia Research, vol. 123, 106969. https://doi.org/10.1016/j.leukres.2022.106969
Pizzola, CJ, Cioccio, J, Rakszawski, KL, Nickolich, M, Ehmann, WC, Rybka, WB, Wirk, B, Naik, S, Zheng, H, Silar, B, Shike, H, Zhou, S, Mineishi, S, Minagawa, K & Claxton, DF 2022, 'Non-myeloablative allogeneic stem cell transplant with fludarabine and reduced dose cyclophosphamide in acute myeloid leukemia for older adults with comorbidities', Bone Marrow Transplantation, vol. 57, no. 11, pp. 1743-1745. https://doi.org/10.1038/s41409-022-01821-4
Jamy, O, Arora, S, Meredith, R, Salzman, D, Di Stasi, A, Minagawa, K, Mineishi, S & Saad, A 2022, 'Phase II study of myeloablative allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia in adults using fludarabine and total body irradiation 12 Gy', Bone Marrow Transplantation, vol. 57, no. 10, pp. 1597-1599. https://doi.org/10.1038/s41409-022-01757-9
2021
Tomita, T, Kato, M, Mishima, T, Matsunaga, Y, Sanjo, H, Ito, KI, Minagawa, K, Matsui, T, Oikawa, H, Takahashi, S, Takao, T, Iwai, N, Mino, T, Takeuchi, O, Maru, Y & Hiratsuka, S 2021, 'Extracellular mRNA transported to the nucleus exerts translation-independent function', Nature communications, vol. 12, no. 1, 3655. https://doi.org/10.1038/s41467-021-23969-1
Ishii, S, Suzuki, T, Wakahashi, K, Asada, N, Kawano, Y, Kawano, H, Sada, A, Minagawa, K, Nakamura, Y, Mizuno, S, Takahashi, S, Matsui, T & Katayama, Y 2021, 'FGF-23 from erythroblasts promotes hematopoietic progenitor mobilization', Blood, vol. 137, no. 11, pp. 1457-1467. https://doi.org/10.1182/blood.2020007172
Shah, N, Rakszawski, K, Nickolich, M, Ehmann, C, Wirk, B, Naik, S, Rybka, W, Zheng, H, Mierski, J, Silar, B, Mackey, G, Greiner, R, Brown, V, Claxton, D, Mineishi, S & Minagawa, K 2021, 'Improved outcome in AML relapse after allogeneic transplant with high-intensity chemotherapy followed by 2nd allogeneic stem cell transplant or donor lymphocyte infusion', Annals of Hematology, vol. 100, no. 10, pp. 2585-2592. https://doi.org/10.1007/s00277-021-04616-7
Suzuki, T, Ishii, S, Shinohara, M, Kawano, Y, Wakahashi, K, Kawano, H, Sada, A, Minagawa, K, Hamada, M, Takahashi, S, Furuyashiki, T, Tan, NS, Matsui, T & Katayama, Y 2021, 'Mobilization efficiency is critically regulated by fat via marrow PPARd', Haematologica, vol. 106, no. 6, pp. 1671-1683. https://doi.org/10.3324/haematol.2020.265751
Jamy, O, Innis-Shelton, R, Bal, S, Paluri, R, Salzman, D, Di Stasi, A, Costa, L, Meredith, R, Lamb, L, Minagawa, K, Mineishi, S & Saad, A 2021, 'Phase II clinical trial of one dose of post-transplant cyclophosphamide for graft versus host disease prevention following myeloablative, peripheral blood stem cell, matched-unrelated donor transplantation', American Journal of Hematology, vol. 96, no. 10, pp. E396-E398. https://doi.org/10.1002/ajh.26296