Researcher Profile

Researcher Profile

Suming Huang, PhD, MS

Suming Huang, PhD, MS

Professor, Department of Pediatrics
Professor, Department of Pharmacology
Division of Hematology and Oncology
Scientific Program:Mechanisms of Carcinogenesis
suh925@psu.edu

Research Interests

  • Genes
  • Chromatin
  • Gene Expression
  • Proteins
  • Globins
  • Acetylation
  • Transcription Factors
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
  • Epigenomics
  • Histones
  • DNA
  • Neoplasms

Recent Publications

2019

Luo, H, Sobh, A, Vulpe, CD, Brewer, E, Dovat, S, Qiu, Y & Huang, S 2019, 'HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries' Journal of visualized experiments : JoVE, no. 145. https://doi.org/10.3791/59382
Ding, Y, Zhang, B, Payne, JL, Song, C, Ge, Z, Gowda, C, Iyer, S, Dhanyamraju, PK, Dorsam, G, Reeves, ME, Desai, D, Huang, S, Payne, KJ, Yue, F & Dovat, S 2019, 'Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity', Leukemia. https://doi.org/10.1038/s41375-019-0474-0

2018

Luo, H, Wang, F, Zha, J, Li, H, Yan, B, Du, Q, Yang, F, Sobh, A, Vulpe, C, Drusbosky, L, Cogle, C, Chepelev, I, Xu, B, Nimer, SD, Licht, J, Qiu, Y, Chen, B, Xu, M & Huang, S 2018, 'CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia', Blood, vol. 132, no. 8, pp. 837-848. https://doi.org/10.1182/blood-2017-11-814319
Shen, Y, Bassett, MA, Gurumurthy, A, Nar, R, Knudson, IJ, Guy, CR, Perez, A, Mellen, RW, Ikeda, M, Hossain, MA, Huang, S, Igarashi, K & Bungert, J 2018, 'Erratum: Identification of a novel enhancer/ chromatin opening element associated with high-level γ-globin gene expression (Molecular and Cellular Biology (2018) 38:19 (e00197-18) DOI: 10.1128/MCB.00197-18)', Molecular and cellular biology, vol. 39, no. 11, e0016819. https://doi.org/10.1128/MCB.00168-19
Yan, B, Chen, Q, Shimada, K, Tang, M, Li, H, Gurumurthy, A, Khoury, JD, Xu, B, Huang, S & Qiu, Y 2019, 'Histone deacetylase inhibitor targets CD123/CD47-positive cells and reverse chemoresistance phenotype in acute myeloid leukemia', Leukemia, vol. 33, no. 4, pp. 931-944. https://doi.org/10.1038/s41375-018-0279-6
Shen, Y, Bassett, MA, Gurumurthy, A, Nar, R, Knudson, IJ, Guy, CR, Perez, A, Mellen, RW, Ikeda, M, Hossain, MA, Huang, S, Igarashi, K & Bungert, J 2018, 'Identification of a novel enhancer/chromatin opening element associated with high-level -globin gene expression', Molecular and cellular biology, vol. 38, no. 19, e00197. https://doi.org/10.1128/MCB.00197-18

2017

Qiu, Y & Huang, S 2017, 'Catching global interactions in vivo' Cell and Bioscience, vol. 7, no. 1, 49. https://doi.org/10.1186/s13578-017-0177-z
Jian, W, Yan, B, Huang, S & Qiu, Y 2017, 'Histone deacetylase 1 activates PU.1 gene transcription through regulating TAF9 deacetylation and transcription factor IID assembly', FASEB Journal, vol. 31, no. 9, pp. 4104-4116. https://doi.org/10.1096/fj.201700022R
Li, X, Mei, Y, Yan, B, Vitriol, E, Huang, S, Ji, P & Qiu, Y 2017, 'Histone deacetylase 6 regulates cytokinesis and erythrocyte enucleation through deacetylation of formin protein mDia2', Haematologica, vol. 102, no. 6, pp. 984-994. https://doi.org/10.3324/haematol.2016.161513
Jin, S, Su, H, Tran, NT, Song, J, Lu, SS, Li, Y, Huang, S, Abdel-Wahab, O, Liu, Y & Zhao, X 2017, 'Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1', PLoS One, vol. 12, no. 5, e0175523. https://doi.org/10.1371/journal.pone.0175523
Pan, F, Wingo, TS, Zhao, Z, Gao, R, Makishima, H, Qu, G, Lin, L, Yu, M, Ortega, JR, Wang, J, Nazha, A, Chen, L, Yao, B, Liu, C, Chen, S, Weeks, O, Ni, H, Phillips, BL, Huang, S, Wang, J, He, C, Li, GM, Radivoyevitch, T, Aifantis, I, MacIejewski, JP, Yang, FC, Jin, P & Xu, M 2017, 'Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells', Nature communications, vol. 8, 15102. https://doi.org/10.1038/ncomms15102

2016

Li, Y & Huang, S 2016, 'Chromatin rules' Stem Cell Investigation, vol. 2016, no. FEB, 4. https://doi.org/10.3978/j.issn.2306-9759.2016.02.02
Stees, JR, Hossain, MA, Sunose, T, Kudo, Y, Pardo, CE, Nabilsi, NH, Darst, RP, Poudyal, R, Igarashi, K, Huang, S, Kladde, MP & Bungert, J 2016, 'High fractional occupancy of a tandem Maf recognition element and its role in long-range β-globin gene regulation', Molecular and cellular biology, vol. 36, no. 2, pp. 238-250. https://doi.org/10.1128/MCB.00723-15
Deng, C, Li, Y, Zhou, L, Cho, J, Patel, B, Terada, N, Li, Y, Bungert, J, Qiu, Y & Huang, S 2016, 'HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development', Cell Reports, vol. 14, no. 1, pp. 103-114. https://doi.org/10.1016/j.celrep.2015.12.007
Xu, L, Weng, J, Huang, X, Zeng, C, Chen, S, Geng, S, Yang, L, Wu, S, Huang, S, Du, X & Li, Y 2016, 'Persistent donor derived Vδ4 T cell clones may improve survival for recurrent T cell acute lymphoblastic leukemia after HSCT and DLI', Oncotarget, vol. 7, no. 28, pp. 42943-42952. https://doi.org/10.18632/oncotarget.10260
Li, Y, Schulz, VP, Deng, C, Li, G, Shen, Y, Tusi, BK, Ma, G, Stees, J, Qiu, Y, Steiner, LA, Zhou, L, Zhao, K, Bungert, J, Gallagher, PG & Huang, S 2016, 'Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation', Nucleic Acids Research, vol. 44, no. 15, pp. 7173-7188. https://doi.org/10.1093/nar/gkw327
Du, Z, Li, L, Huang, X, Jin, J, Huang, S, Zhang, Q & Tao, Q 2016, 'The epigenetic modifier CHD5 functions as a novel tumor suppressor for renal cell carcinoma and is predominantly inactivated by promoter CpG methylation', Oncotarget, vol. 7, no. 16, pp. 21618-21630. https://doi.org/10.18632/oncotarget.7822
Benyoucef, A, Palii, CG, Wang, C, Porter, CJ, Chu, A, Dai, F, Tremblay, V, Rakopoulos, P, Singh, K, Huang, S, Pflumio, F, Hébert, J, Couture, JF, Perkins, TJ, Ge, K, Dilworth, FJ & Brand, M 2016, 'UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia', Genes and Development, vol. 30, no. 5, pp. 508-521. https://doi.org/10.1101/gad.276790.115

2015

Yang, H, Yan, B, Liao, D, Huang, S & Qiu, Y 2015, 'Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress', Cell Death and Disease, vol. 6, no. 5. https://doi.org/10.1038/cddis.2015.106
Deng, C, Patel, B, Lin, X, Li, Y & Huang, S 2015, Chromatin dynamics and genome organization in development and disease. in Epigenetic Gene Expression and Regulation. Elsevier Inc., pp. 95-115. https://doi.org/10.1016/B978-0-12-799958-6.00005-6
Huang, S, Litt, MD & Blakey, CA 2015, Epigenetic Gene Expression and Regulation. Elsevier Inc.
Salz, T, Deng, C, Pampo, C, Siemann, D, Qiu, Y, Brown, K & Huang, S 2015, 'Histone methyltransferase hSETD1A is a novel regulator of metastasis in breast cancer', Molecular Cancer Research, vol. 13, no. 3, pp. 461-469. https://doi.org/10.1158/1541-7786.MCR-14-0389
Tusi, BK, Deng, C, Salz, T, Zeumer, L, Li, Y, So, CWE, Morel, LM, Qiu, Y & Huang, S 2015, 'Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement' FASEB Journal, vol. 29, no. 4, pp. 1505-1515. https://doi.org/10.1096/fj.14-263061

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)