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Suming Huang, PhD, MS

Suming Huang, PhD, MS

Professor and Chair of Four Diamonds Epigenetics and Gene Regulation Research Program in Pediatric Oncology, Department of Pediatrics
Division of Hematology and Oncology
Professor, Department of Pharmacology
Scientific Program:Mechanisms of Carcinogenesis
SUH925@psu.edu

Research Interests

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  • Genes
  • Chromatin
  • Gene Expression
  • Proteins
  • Globins
  • Acetylation
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
  • Transcription Factors
  • Epigenomics
  • Histones
  • Neoplasms
  • DNA
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Recent Publications

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2023

Tumas, KC, Xu, F, Wu, J, Hernandez, M, Pattaradilokrat, S, Xia, L, Peng, YC, Lavali, AM, He, X, Singh, BK, Zhang, C, Percopo, C, Qi, CF, Huang, S, Long, CA & Su, XZ 2023, 'Dysfunction of CD169+ macrophages and blockage of erythrocyte maturation as a mechanism of anemia in Plasmodium yoelii infection', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 40, e2311557120. https://doi.org/10.1073/pnas.2311557120
Lai, Q, Hamamoto, K, Luo, H, Zaroogian, Z, Zhou, C, Lesperance, J, Zha, J, Qiu, Y, Guryanova, OA, Huang, S & Xu, B 2023, 'NPM1 mutation reprograms leukemic transcription network via reshaping TAD topology', Leukemia, vol. 37, no. 8, pp. 1732-1736. https://doi.org/10.1038/s41375-023-01942-9

2022

Singh, AP, Luo, H, Matur, M, Eshelman, MA, Hamamoto, K, Sharma, A, Lesperance, J & Huang, S 2022, 'A coordinated function of lncRNA HOTTIP and miRNA-196b underpinning leukemogenesis by targeting FAS signaling', Oncogene, vol. 41, no. 5, pp. 718-731. https://doi.org/10.1038/s41388-021-02127-3
Luo, H, Zhu, G, Eshelman, MA, Fung, TK, Lai, Q, Wang, F, Zeisig, BB, Lesperance, J, Ma, X, Chen, S, Cesari, N, Cogle, C, Chen, B, Xu, B, Yang, FC, So, CWE, Qiu, Y, Xu, M & Huang, S 2022, 'HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia', Molecular cell, vol. 82, no. 4, pp. 833-851.e11. https://doi.org/10.1016/j.molcel.2022.01.014
Huang, S 2022, 'Paper of April Issue of Stem Cell Reviews and Reports Presents an Update on Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications by Dr. David F. Claxton et al.', Stem Cell Reviews and Reports, vol. 18, no. 4, pp. 1209-1210. https://doi.org/10.1007/s12015-022-10365-5
Zhang, L, Luo, H, Ni, HM, Liu, S, Xing, H, Zhang, J, Sellin, M, Breslin, PSJ, Wei, W, Denning, MF, Small, W, Ding, WX, Huang, S & Zhang, J 2022, 'Ripk3 signaling regulates HSCs during stress and represses radiation-induced leukemia in mice', Stem Cell Reports, vol. 17, no. 6, pp. 1428-1441. https://doi.org/10.1016/j.stemcr.2022.04.009
Hirschler-Laszkiewicz, I, Festa, F, Huang, S, Moldovan, GL, Nicolae, C, Dhoonmoon, A, Bao, L, Keefer, K, Chen, SJ, Wang, HG, Cheung, JY & Miller, BA 2022, 'The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1', Scientific reports, vol. 12, no. 1, 6311. https://doi.org/10.1038/s41598-022-10385-8

2021

Ge, Z, Song, C, Ding, Y, Tan, BH, Desai, D, Sharma, A, Gowda, R, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Iyer, S, Dhanyamraju, PK, Imamura, Y, Bogush, D, Bamme, Y, Yang, Y, Soliman, M, Kane, S, Dovat, E, Schramm, J, Hu, T, McGrath, M, Chroneos, ZC, Payne, KJ, Gowda, C & Dovat, S 2021, 'Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia', Leukemia, vol. 35, no. 5, pp. 1267-1278. https://doi.org/10.1038/s41375-021-01132-5
Zeisig, BB, Fung, TK, Zarowiecki, M, Tsai, CT, Luo, H, Stanojevic, B, Lynn, C, Leung, AYH, Zuna, J, Zaliova, M, Bornhauser, M, von Bonin, M, Lenhard, B, Huang, S, Mufti, GJ & Eric So, CW 2021, 'Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia', Science Translational Medicine, vol. 13, no. 582, eabc4822. https://doi.org/10.1126/scitranslmed.abc4822
Yan, B, Yang, J, Kim, MY, Luo, H, Cesari, N, Yang, T, Strouboulis, J, Zhang, J, Hardison, R, Huang, S & Qiu, Y 2021, 'HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis', Nucleic acids research, vol. 49, no. 17, pp. 9783-9798. https://doi.org/10.1093/nar/gkab737
Zhu, G, Luo, H, Feng, Y, Guryanova, OA, Xu, J, Chen, S, Lai, Q, Sharma, A, Xu, B, Zhao, Z, Feng, R, Ni, H, Claxton, D, Guo, Y, Mesa, RA, Qiu, Y, Yang, FC, Li, W, Nimer, SD, Huang, S & Xu, M 2021, 'HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia', Nature communications, vol. 12, no. 1, 1956. https://doi.org/10.1038/s41467-021-22095-2
Papayanni, PG, Psatha, N, Christofi, P, Li, XG, Melo, P, Volpin, M, Montini, E, Liu, M, Kaltsounis, G, Yiangou, M, Emery, DW, Anagnostopoulos, A, Papayannopoulou, T, Huang, S, Stamatoyannopoulos, G & Yannaki, E 2021, 'Investigating the Barrier Activity of Novel, Human Enhancer-Blocking Chromatin Insulators for Hematopoietic Stem Cell Gene Therapy', Human Gene Therapy, vol. 32, no. 19-20, pp. 1186-1199. https://doi.org/10.1089/hum.2021.142
Qiu, Y, Xu, M & Huang, S 2021, 'Long noncoding RNAs: emerging regulators of normal and malignant hematopoiesis', Blood, vol. 138, no. 23, pp. 2327-2336. https://doi.org/10.1182/blood.2021011992
Klink, M, Rahman, MA, Song, C, Dhanyamraju, PK, Ehudin, M, Ding, Y, Steffens, S, Bhadauria, P, Iyer, S, Aliaga, C, Desai, D, Huang, S, Claxton, D, Sharma, A & Gowda, C 2021, 'Mechanistic basis for in vivo therapeutic efficacy of ck2 inhibitor cx-4945 in acute myeloid leukemia', Cancers, vol. 13, no. 5, 1127, pp. 1-21. https://doi.org/10.3390/cancers13051127
Wei, Y, Luo, H, Yee, PP, Zhang, L, Liu, Z, Zheng, H, Zhang, L, Anderson, B, Tang, M, Huang, S & Li, W 2021, 'Paraspeckle Protein NONO Promotes TAZ Phase Separation in the Nucleus to Drive the Oncogenic Transcriptional Program', Advanced Science, vol. 8, no. 24, 2102653. https://doi.org/10.1002/advs.202102653

2020

Yan, B, Claxton, D, Huang, S & Qiu, Y 2020, 'AML chemoresistance: The role of mutant TP53 subclonal expansion and therapy strategy', Experimental Hematology, vol. 87, pp. 13-19. https://doi.org/10.1016/j.exphem.2020.06.003
Li, Y, Liao, Z, Luo, H, Benyoucef, A, Kang, Y, Lai, Q, Dovat, S, Miller, B, Chepelev, I, Li, Y, Zhao, K, Brand, M & Huang, S 2020, 'Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis', Nucleic acids research, vol. 48, no. 6, pp. 3119-3133. https://doi.org/10.1093/nar/gkaa098
Qiu, Y & Huang, S 2020, 'CTCF-mediated genome organization and leukemogenesis', Leukemia, vol. 34, no. 9, pp. 2295-2304. https://doi.org/10.1038/s41375-020-0906-x
Song, C, Ge, Z, Ding, Y, Tan, BH, Desai, D, Gowda, K, Amin, S, Gowda, R, Robertson, GP, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Gurel, Z, Iyer, S, Dhanyamraju, PK, Xiang, M, Kawasawa, YI, Cury, NM, Yunes, JA, McGrath, M, Schramm, J, Su, R, Yang, Y, Zhao, Z, Lyu, X, Muschen, M, Payne, KJ, Gowda, C & Dovat, S 2020, 'IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia', Blood, vol. 136, no. 13, pp. 1520-1534. https://doi.org/10.1182/blood.2019002655
Kim, MY, Yan, B, Huang, S & Qiu, Y 2020, 'Regulating the regulators: The role of histone deacetylase 1 (hdac1) in erythropoiesis', International journal of molecular sciences, vol. 21, no. 22, 8460, pp. 1-22. https://doi.org/10.3390/ijms21228460
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