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Suming Huang, PhD, MS

Suming Huang, PhD, MS

Professor and Chair of Four Diamonds Epigenetics and Gene Regulation Research Program in Pediatric Oncology, Department of Pediatrics
Division of Hematology and Oncology
Professor, Department of Pharmacology
Scientific Program:Mechanisms of Carcinogenesis

Research Interests

  • Genes
  • Chromatin
  • Gene Expression
  • Proteins
  • Globins
  • Acetylation
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
  • Transcription Factors
  • Epigenomics
  • Histones
  • Neoplasms
  • DNA

Recent Publications


Lynch, J, Troadec, E, Fung, TK, Gladysz, K, Virely, C, Lau, PNI, Cheung, N, Zeisig, B, Wong, JWH, Lopes, M, Huang, S & So, CWE 2024, 'Hematopoietic stem cell quiescence and DNA replication dynamics maintained by the resilient β-catenin/Hoxa9/Prmt1 axis', Blood, vol. 143, no. 16, pp. 1586-1598.


Tumas, KC, Xu, F, Wu, J, Hernandez, M, Pattaradilokrat, S, Xia, L, Peng, YC, Lavali, AM, He, X, Singh, BK, Zhang, C, Percopo, C, Qi, CF, Huang, S, Long, CA & Su, XZ 2023, 'Dysfunction of CD169+ macrophages and blockage of erythrocyte maturation as a mechanism of anemia in Plasmodium yoelii infection', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 40, e2311557120.
Lai, Q, Hamamoto, K, Luo, H, Zaroogian, Z, Zhou, C, Lesperance, J, Zha, J, Qiu, Y, Guryanova, OA, Huang, S & Xu, B 2023, 'NPM1 mutation reprograms leukemic transcription network via reshaping TAD topology', Leukemia, vol. 37, no. 8, pp. 1732-1736.


Singh, AP, Luo, H, Matur, M, Eshelman, MA, Hamamoto, K, Sharma, A, Lesperance, J & Huang, S 2022, 'A coordinated function of lncRNA HOTTIP and miRNA-196b underpinning leukemogenesis by targeting FAS signaling', Oncogene, vol. 41, no. 5, pp. 718-731.
Luo, H, Zhu, G, Eshelman, MA, Fung, TK, Lai, Q, Wang, F, Zeisig, BB, Lesperance, J, Ma, X, Chen, S, Cesari, N, Cogle, C, Chen, B, Xu, B, Yang, FC, So, CWE, Qiu, Y, Xu, M & Huang, S 2022, 'HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia', Molecular cell, vol. 82, no. 4, pp. 833-851.e11.
Huang, S 2022, 'Paper of April Issue of Stem Cell Reviews and Reports Presents an Update on Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications by Dr. David F. Claxton et al.', Stem Cell Reviews and Reports, vol. 18, no. 4, pp. 1209-1210.
Zhang, L, Luo, H, Ni, HM, Liu, S, Xing, H, Zhang, J, Sellin, M, Breslin, PSJ, Wei, W, Denning, MF, Small, W, Ding, WX, Huang, S & Zhang, J 2022, 'Ripk3 signaling regulates HSCs during stress and represses radiation-induced leukemia in mice', Stem Cell Reports, vol. 17, no. 6, pp. 1428-1441.
Hirschler-Laszkiewicz, I, Festa, F, Huang, S, Moldovan, GL, Nicolae, C, Dhoonmoon, A, Bao, L, Keefer, K, Chen, SJ, Wang, HG, Cheung, JY & Miller, BA 2022, 'The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1', Scientific reports, vol. 12, no. 1, 6311.


Ge, Z, Song, C, Ding, Y, Tan, BH, Desai, D, Sharma, A, Gowda, R, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Iyer, S, Dhanyamraju, PK, Imamura, Y, Bogush, D, Bamme, Y, Yang, Y, Soliman, M, Kane, S, Dovat, E, Schramm, J, Hu, T, McGrath, M, Chroneos, ZC, Payne, KJ, Gowda, C & Dovat, S 2021, 'Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia', Leukemia, vol. 35, no. 5, pp. 1267-1278.
Zeisig, BB, Fung, TK, Zarowiecki, M, Tsai, CT, Luo, H, Stanojevic, B, Lynn, C, Leung, AYH, Zuna, J, Zaliova, M, Bornhauser, M, von Bonin, M, Lenhard, B, Huang, S, Mufti, GJ & Eric So, CW 2021, 'Functional reconstruction of human AML reveals stem cell origin and vulnerability of treatment-resistant MLL-rearranged leukemia', Science Translational Medicine, vol. 13, no. 582, eabc4822.
Yan, B, Yang, J, Kim, MY, Luo, H, Cesari, N, Yang, T, Strouboulis, J, Zhang, J, Hardison, R, Huang, S & Qiu, Y 2021, 'HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis', Nucleic acids research, vol. 49, no. 17, pp. 9783-9798.
Zhu, G, Luo, H, Feng, Y, Guryanova, OA, Xu, J, Chen, S, Lai, Q, Sharma, A, Xu, B, Zhao, Z, Feng, R, Ni, H, Claxton, D, Guo, Y, Mesa, RA, Qiu, Y, Yang, FC, Li, W, Nimer, SD, Huang, S & Xu, M 2021, 'HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia', Nature communications, vol. 12, no. 1, 1956.
Papayanni, PG, Psatha, N, Christofi, P, Li, XG, Melo, P, Volpin, M, Montini, E, Liu, M, Kaltsounis, G, Yiangou, M, Emery, DW, Anagnostopoulos, A, Papayannopoulou, T, Huang, S, Stamatoyannopoulos, G & Yannaki, E 2021, 'Investigating the Barrier Activity of Novel, Human Enhancer-Blocking Chromatin Insulators for Hematopoietic Stem Cell Gene Therapy', Human Gene Therapy, vol. 32, no. 19-20, pp. 1186-1199.
Qiu, Y, Xu, M & Huang, S 2021, 'Long noncoding RNAs: emerging regulators of normal and malignant hematopoiesis', Blood, vol. 138, no. 23, pp. 2327-2336.
Klink, M, Rahman, MA, Song, C, Dhanyamraju, PK, Ehudin, M, Ding, Y, Steffens, S, Bhadauria, P, Iyer, S, Aliaga, C, Desai, D, Huang, S, Claxton, D, Sharma, A & Gowda, C 2021, 'Mechanistic basis for in vivo therapeutic efficacy of ck2 inhibitor cx-4945 in acute myeloid leukemia', Cancers, vol. 13, no. 5, 1127, pp. 1-21.
Wei, Y, Luo, H, Yee, PP, Zhang, L, Liu, Z, Zheng, H, Zhang, L, Anderson, B, Tang, M, Huang, S & Li, W 2021, 'Paraspeckle Protein NONO Promotes TAZ Phase Separation in the Nucleus to Drive the Oncogenic Transcriptional Program', Advanced Science, vol. 8, no. 24, 2102653.


Yan, B, Claxton, D, Huang, S & Qiu, Y 2020, 'AML chemoresistance: The role of mutant TP53 subclonal expansion and therapy strategy', Experimental Hematology, vol. 87, pp. 13-19.
Li, Y, Liao, Z, Luo, H, Benyoucef, A, Kang, Y, Lai, Q, Dovat, S, Miller, B, Chepelev, I, Li, Y, Zhao, K, Brand, M & Huang, S 2020, 'Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis', Nucleic acids research, vol. 48, no. 6, pp. 3119-3133.
Qiu, Y & Huang, S 2020, 'CTCF-mediated genome organization and leukemogenesis', Leukemia, vol. 34, no. 9, pp. 2295-2304.
Song, C, Ge, Z, Ding, Y, Tan, BH, Desai, D, Gowda, K, Amin, S, Gowda, R, Robertson, GP, Yue, F, Huang, S, Spiegelman, V, Payne, JL, Reeves, ME, Gurel, Z, Iyer, S, Dhanyamraju, PK, Xiang, M, Kawasawa, YI, Cury, NM, Yunes, JA, McGrath, M, Schramm, J, Su, R, Yang, Y, Zhao, Z, Lyu, X, Muschen, M, Payne, KJ, Gowda, C & Dovat, S 2020, 'IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia', Blood, vol. 136, no. 13, pp. 1520-1534.
Kim, MY, Yan, B, Huang, S & Qiu, Y 2020, 'Regulating the regulators: The role of histone deacetylase 1 (hdac1) in erythropoiesis', International journal of molecular sciences, vol. 21, no. 22, 8460, pp. 1-22.