Researcher Profile

Researcher Profile

Yuan-Wan Sun, MS, PhD

Yuan-Wan Sun, MS, PhD

Assistant Professor, Department of Biochemistry and Molecular Biology
Scientific Program:Cancer Control
yxs12@psu.edu

Research Interests

  • dibenzo(a,l)pyrene
  • Carcinogens
  • DNA Damage
  • Neoplasms
  • Carcinogenesis
  • Environmental Pollutants
  • Mutagenesis
  • Breast
  • Tobacco
  • Mouth
  • Environmental Carcinogens
  • DNA Adducts

Recent Publications

2019

Sun, Y-W, Kosinska, W & Guttenplan, JB 2019, 'E-cigarette aerosol condensate enhances metabolism of benzo(A)pyrene to genotoxic products, and induces CYP1A1 and CYP1B1, likely by activation of the aryl hydrocarbon receptor', International journal of environmental research and public health, vol. 16, no. 14, 2468. https://doi.org/10.3390/ijerph16142468
Guttenplan, JB, Chen, K-M, Sun, Y-W, Shalaby, NAE, Kosinska, W, Desai, D, Gowda, K, Amin, S & El-Bayoumy, K 2019, 'Effects of the Tobacco Carcinogens N′-Nitrosonornicotine and Dibenzo[ a, l]pyrene Individually and in Combination on DNA Damage in Human Oral Leukoplakia and on Mutagenicity and Mutation Profiles in lacI Mouse Tongue', Chemical research in toxicology, vol. 32, no. 9, pp. 1893-1899. https://doi.org/10.1021/acs.chemrestox.9b00257
Sun, Y-W, Xu, H, Benitez, G, Chen, KM, Stanley, A, Stanley, B, Zhu, J, Thompson, H, Manni, A & El-Bayoumy, K 2019, 'Omega-3 Fatty Acids Responsive Proteins and Reduction in Breast Density in Obese Postmenopausal Women', Journal of Proteome Research, vol. 18, no. 9, pp. 3461-3469. https://doi.org/10.1021/acs.jproteome.9b00356

2018

Chen, K-M, Sun, Y-W, Cooper, TK, Benitez, G, Aliaga, C, Zhu, J, Gowda, K, Amin, S & El-Bayoumy, K 2018, 'Comparative Tumorigenicity and DNA Damage Induced by Dibenzo[ def,p]chrysene and Its Metabolites in the Mouse Ovary', Chemical Research in Toxicology, vol. 31, no. 11, pp. 1111-1118. https://doi.org/10.1021/acs.chemrestox.8b00152
Chen, K-M, Guttenplan, JB, Sun, Y-W, Cooper, T, Shalaby, NAE, Kosinska, W, Benitez, G, Aliaga, C, Zhu, J, Liao, JJ, Gowda, K, Amin, S, Stoner, G & El-Bayoumy, K 2018, 'Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNAAdducts, Mutagenesis, and Tumorigenesis in the Mouse Oral Cavity', Cancer Prevention Research, vol. 11, no. 3, pp. 157-164. https://doi.org/10.1158/1940-6207.CAPR-17-0278

2017

El-Bayoumy, K, Chen, K-M, Zhang, SM, Sun, Y-W, Amin, S, Stoner, G & Guttenplan, JB 2017, 'Carcinogenesis of the oral cavity: Environmental causes and potential prevention by black raspberry', Chemical Research in Toxicology, vol. 30, no. 1, pp. 126-144. https://doi.org/10.1021/acs.chemrestox.6b00306
Guttenplan, JB, Chen, K-M, Sun, Y-W, Lajara, B, Shalaby, NAE, Kosinska, W, Benitez, G, Gowda, K, Amin, S, Stoner, G & El-Bayoumy, K 2017, 'Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts', Chemical Research in Toxicology, vol. 30, no. 12, pp. 2159-2164. https://doi.org/10.1021/acs.chemrestox.7b00242
Chen, K-M, Schell, T, Richie, J, Sun, Y-W, Zhang, SM, Calcagnotto, A, Aliaga, C, Gowda, K, Amin, S & El-Bayoumy, K 2017, 'Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice', Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews, vol. 35, no. 4, pp. 213-222. https://doi.org/10.1080/10590501.2017.1391514
Sun, Y-W, Chen, K-M, Imamura, Y, Salzberg, AC, Cooper, TK, Caruso, C, Aliaga, C, Zhu, J, Gowda, K, Amin, S & El-Bayoumy, K 2017, 'Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene', PloS one, vol. 12, no. 10, e0186873. https://doi.org/10.1371/journal.pone.0186873

2016

Sun, Y-W, Chen, KY, Kwon, CH & Chen, K-M 2016, 'CK0403, a 9-aminoacridine, is a potent anti-cancer agent in human breast cancer cells', Molecular medicine reports, vol. 13, no. 1, pp. 933-938. https://doi.org/10.3892/mmr.2015.4604
Guttenplan, JB, Chen, K-M, Sun, Y-W, Kosinska, W, Zhou, Y, Kim, SA, Sung, Y, Gowda, K, Amin, S, Stoner, GD & El-Bayoumy, K 2016, 'Effects of black raspberry extract and protocatechuic acid on carcinogen-DNA adducts and mutagenesis, and oxidative stress in rat and human oral cells', Cancer Prevention Research, vol. 9, no. 8, pp. 704-712. https://doi.org/10.1158/1940-6207.CAPR-16-0003

2015

Sun, Y-W, El-Bayoumy, K, Aliaga, C, Awad, A, Gowda, K, Amin, S & Chen, K-M 2015, 'Tissue Distribution, Excretion and Pharmacokinetics of the Environmental Pollutant Dibenzo[def,p]chrysene in Mice' Chemical Research in Toxicology, vol. 28, no. 7, pp. 1427-1433. https://doi.org/10.1021/acs.chemrestox.5b00097

Clinical Trials Search


Children (age < 18 years)
Adults (age >= 18 years)