Edward Harhaj, PhD - Penn State Cancer Institute
Researcher Profile
Edward Harhaj, PhD
Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2024
Kazzaz, SA, Shaikh, KA, White, J, Zhou, Q, Powell, WH & Harhaj, EW 2024, 'Phosphorylation of aryl hydrocarbon receptor interacting protein by TBK1 negatively regulates IRF7 and the type I interferon response', Journal of Biological Chemistry, vol. 300, no. 1, 105525. https://doi.org/10.1016/j.jbc.2023.105525
White, J, Choi, YB, Zhang, J, Vo, MT, He, C, Shaikh, K & Harhaj, EW 2024, 'Phosphorylation of the selective autophagy receptor TAX1BP1 by TBK1 and IKBKE/IKKi promotes ATG8-family protein-dependent clearance of MAVS aggregates', Autophagy. https://doi.org/10.1080/15548627.2024.2394306
Kazzaz, SA, Tawil, J & Harhaj, EW 2024, 'The aryl hydrocarbon receptor-interacting protein in cancer and immunity: Beyond a chaperone protein for the dioxin receptor', Journal of Biological Chemistry, vol. 300, no. 4, 107157. https://doi.org/10.1016/j.jbc.2024.107157
Mohanty, S, Suklabaidya, S, Lavorgna, A, Ueno, T, Fujisawa, JI, Ngouth, N, Jacobson, S & Harhaj, EW 2024, 'The tyrosine kinase KDR is essential for the survival of HTLV-1-infected T cells by stabilizing the Tax oncoprotein', Nature communications, vol. 15, no. 1, 5380. https://doi.org/10.1038/s41467-024-49737-5
2023
Mohanty, S & Harhaj, EW 2023, 'Mechanisms of Innate Immune Sensing of HTLV-1 and Viral Immune Evasion', Pathogens, vol. 12, no. 5, 735. https://doi.org/10.3390/pathogens12050735
2022
White, J, Suklabaidya, S, Vo, MT, Choi, YB & Harhaj, EW 2023, 'Multifaceted roles of TAX1BP1 in autophagy', Autophagy, vol. 19, no. 1, pp. 44-53. https://doi.org/10.1080/15548627.2022.2070331
Madugula, KK, Joseph, J, DeMarino, C, Ginwala, R, Teixeira, V, Khan, ZK, Sales, D, Wilson, S, Kashanchi, F, Rushing, AW, Lemasson, I, Harhaj, EW, Janakiram, M, Hilda Ye, B & Jain, P 2022, 'Regulation of human T-cell leukemia virus type 1 antisense promoter by myocyte enhancer factor-2C in the context of adult T-cell leukemia and lymphoma', Haematologica, vol. 107, no. 12, pp. 2928-2943. https://doi.org/10.3324/haematol.2021.279542
2020
Harhaj, EW & Shembade, N 2020, 'Lymphotropic viruses: Chronic inflammation and induction of cancers', Biology, vol. 9, no. 11, 390, pp. 1-15. https://doi.org/10.3390/biology9110390
Mohanty, S & Harhaj, EW 2020, 'Mechanisms of oncogenesis by HTLV-1 tax', Pathogens, vol. 9, no. 7, 543, pp. 1-28. https://doi.org/10.3390/pathogens9070543
Mohanty, S, Han, T, Choi, YB, Lavorgna, A, Zhang, J & Harhaj, EW 2020, 'The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-κB activation', PLoS pathogens, vol. 16, no. 12, e1008504. https://doi.org/10.1371/journal.ppat.1008504