Hyun Jin Kwun, PhD - Penn State Cancer Institute
Researcher Profile
Hyun Jin Kwun, PhD
Assistant Professor, Department of Microbiology and Immunology
Scientific Program:Mechanisms of Carcinogenesis
Recent Publications
2023
Pham, AM, Ortiz, LE, Lukacher, AE & Kwun, HJ 2023, 'Merkel Cell Polyomavirus Large T Antigen Induces Cellular Senescence for Host Growth Arrest and Viral Genome Persistence through Its Unique Domain', Cells, vol. 12, no. 3, 380. https://doi.org/10.3390/cells12030380
2022
Koubek, EJ, Weissenrieder, JS, Ortiz, LE, Nwogu, N, Pham, AM, Weissenkampen, JD, Reed, JL, Neighbors, JD, Hohl, RJ & Kwun, HJ 2022, 'Therapeutic Potential of 5′-Methylschweinfurthin G in Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma', Viruses, vol. 14, no. 9, 1848. https://doi.org/10.3390/v14091848
2021
Ortiz, LE, Pham, AM & Kwun, HJ 2021, 'Identification of the merkel cell polyomavirus large tumor antigen ubiquitin conjugation residue', International journal of molecular sciences, vol. 22, no. 13, 7169. https://doi.org/10.3390/ijms22137169
2020
Nwogu, N, Ortiz, LE & Kwun, HJ 2020, 'Merkel Cell Polyomavirus Large T Antigen Unique Domain Regulates Its Own Protein Stability and Cell Growth', Viruses, vol. 12, no. 9, 1043. https://doi.org/10.3390/v12091043
Nwogu, N, Ortiz, LE, Whitehouse, A & Kwun, HJ 2020, 'Merkel cell polyomavirus small tumor antigen activates matrix metallopeptidase-9 gene expression for cell migration and invasion', Journal of virology, vol. 94, no. 19, e00786. https://doi.org/10.1128/JVI.00786-20
Orellana, JA, Kwun, HJ, Artusi, S, Chang, Y & Moore, PS 2020, 'Sirolimus and Other Mechanistic Target of Rapamycin Inhibitors Directly Activate Latent Pathogenic Human Polyomavirus Replication', Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiaa071
Nwogu, N, Ortiz, LE & Kwun, HJ 2020, 'Surface charge of Merkel cell polyomavirus small T antigen determines cell transformation through allosteric FBW7 WD40 domain targeting', Oncogenesis, vol. 9, no. 5, 53. https://doi.org/10.1038/s41389-020-0235-y